Detailed information for compound 1403066

Basic information

Technical information
  • TDR Targets ID: 1403066
  • Name: 2,3-dihydro-1,4-benzodioxin-7-yl-(4-methylpip eridin-1-yl)methanone
  • MW: 261.316 | Formula: C15H19NO3
  • H donors: 0 H acceptors: 1 LogP: 2.38 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=O)c1ccc2c(c1)OCCO2
  • InChi: 1S/C15H19NO3/c1-11-4-6-16(7-5-11)15(17)12-2-3-13-14(10-12)19-9-8-18-13/h2-3,10-11H,4-9H2,1H3
  • InChiKey: YQGFBFRGFZFRHZ-UHFFFAOYSA-N  


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Synonyms

  • 2,3-dihydro-1,4-benzodioxin-7-yl-(4-methyl-1-piperidyl)methanone
  • 2,3-dihydro-1,4-benzodioxin-7-yl-(4-methyl-1-piperidinyl)methanone
  • 1-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-4-methylpiperidine
  • MLS000064105
  • SMR000075956
  • Oprea1_604693
  • TULIP016946
  • SDCCGMLS-0037296.P002
  • (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(4-methyl-piperidin-1-yl)-methanone
  • BAS 07339439
  • ZINC00620304

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae putative cytochrome p450 0.0033 0.0097 0.0747
Schistosoma mansoni DNA helicase recq1 0.0024 0.0055 0.0052
Trypanosoma brucei cytochrome P450, putative 0.0116 0.0466 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0362 0.5822
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.053 0.8793
Brugia malayi neuropeptide F receptor 0.002 0.0036 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0288
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0076 0.0356
Onchocerca volvulus 0.002 0.0036 0.003
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0036 0.0034
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0055 0.1132
Brugia malayi neuropeptide F receptor 0.002 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0056 0.005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0298 0.1279 0.1277
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Onchocerca volvulus 0.002 0.0036 0.003
Leishmania major trypanothione reductase 0.0057 0.0203 0.3883
Schistosoma mansoni amine GPCR 0.002 0.0036 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0033 0.0097 0.1084
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0732
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0033 0.0097 0.1084
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0043 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.0057
Schistosoma mansoni histamine h1 receptor 0.002 0.0036 0.0034
Entamoeba histolytica hypothetical protein 0.0043 0.0142 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0076 0.092
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Brugia malayi follicle stimulating hormone receptor 0.0298 0.1279 0.1268
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0036 0.003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0036 0.0024
Onchocerca volvulus 0.002 0.0036 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0142 0.0106
Schistosoma mansoni hypothetical protein 0.002 0.0036 0.0034
Treponema pallidum NADH oxidase 0.002 0.0036 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0097 0.0084
Schistosoma mansoni amine GPCR 0.002 0.0036 0.0034
Plasmodium vivax glutathione reductase, putative 0.0057 0.0203 0.5613
Brugia malayi Dopamine receptor protein 1 0.002 0.0036 0.0024
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0036 0.0996
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0109 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0076 0.0063
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0142 0.014
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0033 0.0097 0.141
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0033 0.0097 0.141
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0036 0.0034
Brugia malayi cytochrome P450 0.0033 0.0097 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.029 0.0288
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0109 0.3008
Loa Loa (eye worm) glutathione reductase 0.0057 0.0203 0.0201
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0033 0.0097 0.141
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0036 0.0996
Brugia malayi glutathione reductase 0.0057 0.0203 0.0191
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0033 0.0097 0.1084
Brugia malayi Cytochrome P450 family protein 0.0116 0.0466 0.0454
Plasmodium vivax SET domain protein, putative 0.0036 0.0109 0.3008
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0076 0.092
Brugia malayi G protein-coupled receptor 0.002 0.0036 0.0024
Loa Loa (eye worm) cytochrome P450 0.0033 0.0097 0.0095
Schistosoma mansoni neuropeptide receptor 0.002 0.0036 0.0034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0203 0.0168
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0036 0.0034
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0033 0.0097 0.141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0107
Brugia malayi TAR-binding protein 0.0076 0.029 0.0278
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0033 0.0097 0.141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0052
Onchocerca volvulus 0.002 0.0036 0.003
Trypanosoma brucei trypanothione reductase 0.0057 0.0203 0.3883
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0076 0.0356
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0055 0.0052
Echinococcus multilocularis 0.0033 0.0097 0.0061
Mycobacterium tuberculosis Probable reductase 0.013 0.053 0.8837
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0033 0.0097 0.1084
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0036 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0043 0.0167
Brugia malayi larval opioid receptor 0.002 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0076 0.092
Entamoeba histolytica hypothetical protein 0.0043 0.0142 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0203 0.2985
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0732
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0033 0.0097 0.1084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0107
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0055 0.057
Schistosoma mansoni hypothetical protein 0.0058 0.0208 0.0206
Brugia malayi RE15519p 0.002 0.0036 0.0024
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0033 0.0097 0.141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0595 1
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0093 0.0362 0.036
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0097 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0074
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0055 0.057
Schistosoma mansoni neuropeptide receptor 0.002 0.0036 0.0034
Brugia malayi G-protein coupled receptor 0.002 0.0036 0.0024
Brugia malayi Cytochrome P450 family protein 0.0116 0.0466 0.0454
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0055 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0595 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0033 0.0097 0.1084
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0056 0.0044
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0055 0.0042
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0055 0.0431
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0203 0.4331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0076 0.092
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0055 0.0431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0036 0.0732
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0002 0.0057
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0036 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0466 0.0464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0036 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0107
Leishmania major cytochrome p450-like protein 0.0033 0.0097 0.141
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Echinococcus multilocularis tar DNA binding protein 0.0076 0.029 0.0255
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0033 0.0097 0.141
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0036 0.0024
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0203 0.0201
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0362 1
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0036 0.0024
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0033 0.0097 0.141
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0036 0.0034
Schistosoma mansoni hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0074
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0036 0.0034
Brugia malayi hypothetical protein 0.0286 0.1225 0.1214
Trypanosoma cruzi cytochrome P450, putative 0.0116 0.0466 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0055 0.0052
Echinococcus granulosus tar DNA binding protein 0.0076 0.029 0.0255
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0033 0.0097 0.1084
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0055 0.1509
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0109 0.0107
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0208 0.0196
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0056 0.0364
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0033 0.0097 0.141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0033 0.0097 0.1084
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0055 0.0156
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0036 0.0024
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0033 0.0097 0.2039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0732
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Schistosoma mansoni biogenic amine receptor 0.002 0.0036 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0076 0.092
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0036 0.0732
Brugia malayi Serotonin receptor 0.002 0.0036 0.0024
Brugia malayi Melatonin receptor type 1A 0.002 0.0036 0.0024
Schistosoma mansoni hypothetical protein 0.0043 0.0142 0.014
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0033 0.0097 0.141
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0288
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0109 0.0107
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0055 0.0156
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0076 0.092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0041
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.053 0.8837
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.053 0.8837
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0033 0.0097 0.1084
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Schistosoma mansoni opsin-like receptor 0.002 0.0036 0.0034
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0036 0.0034
Schistosoma mansoni myosin xvIII 0.002 0.0036 0.0034
Brugia malayi Serotonin receptor 0.002 0.0036 0.0024
Onchocerca volvulus 0.0058 0.0208 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0076 0.0063
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0036 0.0034
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0097 0.2039
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0362 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0036 0.0034
Brugia malayi Cytochrome P450 family protein 0.0033 0.0097 0.0084
Schistosoma mansoni hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0054
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0362 0.5664
Toxoplasma gondii thioredoxin reductase 0.0057 0.0203 0.5613
Schistosoma mansoni amine GPCR 0.002 0.0036 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0076 0.092
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0036 0.0034
Brugia malayi RNA binding protein 0.0076 0.029 0.0278
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0076 0.5328
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.029 0.0278
Chlamydia trachomatis endonuclease IV 0.0093 0.0362 1
Schistosoma mansoni hypothetical protein 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0033 0.0097 0.1084
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0033 0.0097 0.141
Loa Loa (eye worm) hypothetical protein 0.0083 0.0317 0.0315
Brugia malayi Pre-SET motif family protein 0.0251 0.1072 0.1061
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0055 0.0042
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0033 0.0097 0.1084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0041
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4328 0.4307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0109 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0033 0.0097 0.1084
Onchocerca volvulus 0.0286 0.1227 0.1222
Mycobacterium ulcerans hypothetical protein 0.0024 0.0056 0.0474
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0595 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0055 0.0019
Schistosoma mansoni DNA helicase recq5 0.0024 0.0055 0.0052
Brugia malayi Thioredoxin reductase 0.0057 0.0203 0.0191
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0033 0.0097 0.141
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0033 0.0097 0.1084
Onchocerca volvulus 0.002 0.0036 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0203 0.5613
Onchocerca volvulus 0.002 0.0036 0.003
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0033 0.0097 0.1084
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0076 0.092
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0033 0.0097 0.141
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.053 0.8837
Entamoeba histolytica hypothetical protein 0.0043 0.0142 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0033 0.0097 0.2673
Trypanosoma cruzi cytochrome P450, putative 0.0116 0.0466 1
Brugia malayi G-protein coupled receptor 0.002 0.0036 0.0024
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0043 0.1195
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0033 0.0097 0.141
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0033 0.0097 0.1084
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0076 0.0707
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0142 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Plasmodium falciparum glutathione reductase 0.0057 0.0203 0.5127
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.000000000044152
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0036 0.0024
Mycobacterium ulcerans endonuclease IV 0.0093 0.0362 0.7573
Schistosoma mansoni biogenic amine receptor 0.002 0.0036 0.0034
Schistosoma mansoni hypothetical protein 0.0033 0.0097 0.0095
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0036 0.0034
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0055 0.0019
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0033 0.0097 0.141
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0033 0.0097 0.1084
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1227 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0056 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) RNA binding protein 0.0076 0.029 0.0288
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0033 0.0097 0.1084
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0288
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0036 0.0024
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0036 0.0732
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Leishmania major cytochrome p450-like protein 0.0116 0.0466 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0055 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0103 0.0067
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0036 0.0034
Schistosoma mansoni biogenic amine receptor 0.002 0.0036 0.0034
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0036 0.0996
Mycobacterium leprae Conserved hypothetical protein 0.0033 0.0097 0.0747
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0002 0.0146
Mycobacterium ulcerans hypothetical protein 0.0029 0.0076 0.092
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0033 0.0097 0.141
Onchocerca volvulus 0.0029 0.0076 0.007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0097 0.2039
Onchocerca volvulus 0.0036 0.0109 0.0103
Schistosoma mansoni adenoreceptor 0.002 0.0036 0.0034
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0036 0.0034
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0036 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0033 0.0097 0.1084
Onchocerca volvulus 0.002 0.0036 0.003
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0033 0.0097 0.141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0036 0.0034
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0036 0.0034
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0036 0.0034
Brugia malayi ORL1-like opioid receptor 0.002 0.0036 0.0024
Onchocerca volvulus 0.002 0.0036 0.003
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0033 0.0097 0.141
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0076 0.5328
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0033 0.0097 0.1084
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0036 0.0024
Plasmodium falciparum thioredoxin reductase 0.0057 0.0203 0.5127
Brugia malayi hypothetical protein 0.0043 0.0142 0.0129
Echinococcus granulosus bloom syndrome protein 0.0024 0.0055 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0732
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0055 0.0156
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0055 0.0019
Onchocerca volvulus 0.002 0.0036 0.003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0595 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0036 0.0034
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0033 0.0097 0.141
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0033 0.0097 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0076 0.092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0732
Echinococcus granulosus cytochrome P450 2K1 0.0033 0.0097 0.0061
Brugia malayi AKH receptor 0.002 0.0036 0.0024
Mycobacterium ulcerans epimerase 0.0024 0.0056 0.0474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0116 0.0466 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0732
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0043 0.0221
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0038 0.0035
Leishmania major cytochrome p450-like protein 0.0033 0.0097 0.141
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0076 0.0063
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0055 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0076 0.092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Giardia lamblia Ceramide glucosyltransferase 0.1019 0.4505 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0055 0.1509
Entamoeba histolytica hypothetical protein 0.0043 0.0142 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0033 0.0097 0.141
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0076 0.0707
Brugia malayi Pre-SET motif family protein 0.0036 0.0109 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0038 0.0035
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Brugia malayi sulfakinin receptor protein 0.002 0.0036 0.0024
Schistosoma mansoni amine GPCR 0.002 0.0036 0.0034
Schistosoma mansoni neuropeptide receptor 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Schistosoma mansoni survival motor neuron protein 0.0058 0.0208 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1072 0.107
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0288
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Toxoplasma gondii endonuclease IV APN 0.0093 0.0362 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0036 0.0024
Schistosoma mansoni amine GPCR 0.002 0.0036 0.0034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0036 0.0034
Brugia malayi Dopamine receptor 0.002 0.0036 0.0024
Onchocerca volvulus 0.002 0.0036 0.003
Brugia malayi GnHR receptor homolog 0.002 0.0036 0.0024
Brugia malayi Dopamine receptor protein 2 0.002 0.0036 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0076 0.5328
Loa Loa (eye worm) TAR-binding protein 0.0076 0.029 0.0288
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0055 0.0042
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1225 0.1193
Schistosoma mansoni opsin-like receptor 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Schistosoma mansoni opsin-like receptor 0.002 0.0036 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0466 0.0464
Brugia malayi putative neuropeptide receptor 0.002 0.0036 0.0024
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0036 0.0034
Onchocerca volvulus 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0055 0.3847
Loa Loa (eye worm) hypothetical protein 0.0286 0.1225 0.1223
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0043 0.0221
Schistosoma mansoni cytochrome P450 0.0033 0.0097 0.0095
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0036 0.0034
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0203 0.0168
Loa Loa (eye worm) CYP4Cod1 0.0116 0.0466 0.0464
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.053 0.8837
Schistosoma mansoni neuropeptide receptor 0.002 0.0036 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0036 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0036 0.0996
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.053 0.8837
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0109 0.0073
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0036 0.0034
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0362 0.0349
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0033 0.0097 0.141
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1225 0.1193
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0036 0.5
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0033 0.0097 0.141
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0288
Brugia malayi hypothetical protein 0.002 0.0036 0.0024
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0036 0.0034

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0398 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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