Detailed information for compound 1407423

Basic information

Technical information
  • TDR Targets ID: 1407423
  • Name: N-[diethoxyphosphoryl-(4-methylphenyl)methyl] -3-(trifluoromethyl)aniline
  • MW: 401.36 | Formula: C19H23F3NO3P
  • H donors: 1 H acceptors: 1 LogP: 4.76 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)(C(c1ccc(cc1)C)Nc1cccc(c1)C(F)(F)F)OCC
  • InChi: 1S/C19H23F3NO3P/c1-4-25-27(24,26-5-2)18(15-11-9-14(3)10-12-15)23-17-8-6-7-16(13-17)19(20,21)22/h6-13,18,23H,4-5H2,1-3H3
  • InChiKey: QCOOWRKYSXWUEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [diethoxyphosphoryl-(4-methylphenyl)methyl]-[3-(trifluoromethyl)phenyl]amine
  • MLS000569547
  • SMR000184320
  • diethyl ((4-methylphenyl){[3-(trifluoromethyl)phenyl]amino}methyl)phosphonate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0086 0.0325 0.0391
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Schistosoma mansoni microtubule-associated protein tau 0.1456 0.7517 0.7517
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Schistosoma mansoni cathepsin F (C01 family) 0.0834 0.4251 0.4251
Plasmodium falciparum serine repeat antigen 6 0.0198 0.0913 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0456 0.2266 0.5264
Loa Loa (eye worm) trypsin family protein 0.0034 0.0057 0.0057
Mycobacterium tuberculosis Probable peptidase 0.062 0.3126 0.452
Plasmodium falciparum serine repeat antigen 5 0.0198 0.0913 0.2148
Trichomonas vaginalis calmodulin, putative 0.0095 0.0374 0.075
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.006 0.002
Trichomonas vaginalis calpain, putative 0.0176 0.0801 0.1768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0198 0.0913 0.2148
Plasmodium vivax proteasome subunit beta type-1, putative 0.0066 0.0225 0.053
Leishmania major protein kinase, putative 0.0093 0.0366 0.0468
Onchocerca volvulus 0.0093 0.0366 0.0468
Entamoeba histolytica cysteine protease, putative 0.0198 0.0913 0.1976
Echinococcus granulosus proteasome prosome macropain 0.0086 0.0325 0.0325
Echinococcus granulosus histone deacetylase 6 0.01 0.0402 0.0402
Onchocerca volvulus 0.0576 0.2898 0.3708
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0801 0.1768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Loa Loa (eye worm) glycogen phosphorylase 0.0107 0.0437 0.0437
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0366 0.0366
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0185 0.0847 0.0847
Echinococcus granulosus EF hand domain containing family member A2 0.0093 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Chlamydia trachomatis glycogen phosphorylase 0.0107 0.0437 0.5
Plasmodium falciparum histone deacetylase 1 0.0089 0.0344 0.081
Entamoeba histolytica cysteine protease, putative 0.0198 0.0913 0.1976
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0205 0.0205
Echinococcus granulosus calpain A 0.0586 0.2951 0.2951
Echinococcus multilocularis prolyl endopeptidase 0.1513 0.7815 0.7815
Brugia malayi Pre-SET motif family protein 0.0432 0.2144 0.2144
Toxoplasma gondii calcium-dependent protein kinase 0.0095 0.0374 0.0479
Onchocerca volvulus 0.0135 0.0585 0.0749
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0537 0.0537
Trichomonas vaginalis myosin light chain 1, putative 0.0093 0.0366 0.073
Onchocerca volvulus 0.0834 0.4251 0.544
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.0057 0.0057
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Trichomonas vaginalis calcineurin B subunit, putative 0.0093 0.0366 0.073
Echinococcus multilocularis calumenin 0.0095 0.0374 0.0374
Echinococcus multilocularis proteasome (prosome, macropain) 0.0086 0.0325 0.0325
Brugia malayi prolyl oligopeptidase family protein 0.0527 0.2642 0.2642
Trypanosoma brucei calmodulin, putative 0.0093 0.0366 0.0402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0362 0.0362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Trypanosoma cruzi kinesin, putative 0.041 0.2027 0.2027
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.005 0.014 0.014
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0344 0.0678
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Plasmodium falciparum serine repeat antigen 2 0.0198 0.0913 0.2148
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0527 0.2642 0.3381
Echinococcus granulosus calpain 0.0586 0.2951 0.2951
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0198 0.0913 0.1976
Entamoeba histolytica hypothetical protein 0.0198 0.0913 0.1976
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Echinococcus granulosus cysteine protease 0.0456 0.2266 0.2266
Echinococcus multilocularis calpain family protein 1, d 0.1144 0.5877 0.5877
Schistosoma mansoni histone deacetylase hda2 0.0106 0.0435 0.0435
Echinococcus multilocularis neurocalcin 0.0093 0.0366 0.0366
Brugia malayi Calmodulin-like protein 0.0093 0.0366 0.0366
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0095 0.0374 0.0374
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0176 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0062 0.02 0.02
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0586 0.2951 0.3733
Onchocerca volvulus 0.0834 0.4251 0.544
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0801 0.1768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0041 0.0093 0.0093
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0344 0.0678
Brugia malayi CXXC zinc finger family protein 0.0028 0.0025 0.0025
Echinococcus granulosus histone deacetylase 6 0.0106 0.0435 0.0435
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0372 0.0372
Brugia malayi calpain family protein 1 0.1554 0.8027 0.8027
Echinococcus granulosus calmodulin 0.0093 0.0366 0.0366
Echinococcus granulosus programmed cell death protein 0.0093 0.0366 0.0366
Trypanosoma brucei calmodulin, putative 0.0095 0.0374 0.0413
Echinococcus granulosus centrin 2 0.0093 0.0366 0.0366
Brugia malayi Histone deacetylase 1 0.0089 0.0344 0.0344
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.0093 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0093 0.0366 0.0366
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0586 0.2951 0.2951
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0198 0.0913 0.226
Leishmania major phospholipase c-like protein 0.0093 0.0366 0.0468
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Leishmania major hypothetical protein, conserved 0.0093 0.0366 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0091 0.0091
Onchocerca volvulus Histone deacetylase 10 homolog 0.0043 0.0102 0.0131
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0198 0.0913 0.0913
Trypanosoma cruzi major cysteine proteinase, putative 0.0198 0.0913 0.0913
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2951 0.3733
Onchocerca volvulus 0.0968 0.4953 0.6338
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.062 0.3126 0.3126
Echinococcus multilocularis geminin 0.0169 0.0763 0.0763
Trypanosoma cruzi I/6 autoantigen, putative 0.0093 0.0366 0.0366
Plasmodium vivax histone deacetylase 2, putative 0.01 0.0402 0.0945
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0344 0.0678
Loa Loa (eye worm) hypothetical protein 0.0043 0.0102 0.0102
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1513 0.7815 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.1513 0.7815 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0091 0.0091
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0198 0.0913 0.2148
Leishmania major calcineurin B subunit, putative 0.0093 0.0366 0.0468
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Entamoeba histolytica prolyl oligopeptidase family protein 0.0185 0.0847 0.1818
Entamoeba histolytica hypothetical protein, conserved 0.0185 0.0847 0.1818
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0185 0.0847 0.1818
Onchocerca volvulus 0.005 0.014 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0054 0.0054
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0801
Loa Loa (eye worm) cysteine protease 0.0834 0.4251 0.4251
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2951 0.2951
Loa Loa (eye worm) proteasome subunit beta type 2 0.0041 0.0093 0.0093
Loa Loa (eye worm) prolyl oligopeptidase 0.0185 0.0847 0.0847
Onchocerca volvulus 0.0035 0.006 0.0077
Brugia malayi beta-lactamase 0.0035 0.006 0.006
Brugia malayi cathepsin L-like precursor 0.0576 0.2898 0.2898
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0801 0.1768
Schistosoma mansoni cathepsin C 0.0198 0.0913 0.0913
Trypanosoma brucei prolyl oligopeptidase, putative 0.062 0.3126 0.3959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.0913 0.2035
Loa Loa (eye worm) hypothetical protein 0.0198 0.0913 0.0913
Echinococcus multilocularis histone deacetylase 6 0.01 0.0402 0.0402
Leishmania major programmed cell death 6 protein-like protein 0.0093 0.0366 0.0468
Brugia malayi cathepsin Z-like cysteine proteinase 0.0198 0.0913 0.0913
Giardia lamblia Hypothetical protein 0.0198 0.0913 0.226
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0537 0.1573
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Trypanosoma brucei calpain, putative 0.0176 0.0801 0.0963
Brugia malayi calpain 5 0.041 0.2027 0.2027
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2951 0.2951
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0402 0.0402
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Echinococcus multilocularis histone deacetylase 0.01 0.0402 0.0402
Plasmodium vivax histone deacetylase, putative 0.01 0.0402 0.0945
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0281 0.1348 0.1348
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0243 0.1149 0.1149
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0913 0.2035
Toxoplasma gondii EF hand domain-containing protein 0.0093 0.0366 0.0468
Trypanosoma brucei oligopeptidase b 0.062 0.3126 0.3959
Echinococcus multilocularis neuronal calcium sensor 0.0093 0.0366 0.0366
Toxoplasma gondii cathepsin CPC2 0.0198 0.0913 0.1168
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0281 0.1348 0.1726
Onchocerca volvulus 0.0035 0.006 0.0077
Trypanosoma cruzi cruzipain precursor, putative 0.0934 0.4778 0.4778
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0733 0.3723 0.3723
Schistosoma mansoni calmodulin related calcium binding protein 0.0093 0.0366 0.0366
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.02 0.02
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.006 0.006
Toxoplasma gondii prolyl endopeptidase 0.1513 0.7815 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Loa Loa (eye worm) EF hand family protein 0.0093 0.0366 0.0366
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1048 0.1456
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0456 0.2266 0.2266
Echinococcus granulosus EF HAND 1 calcium binding site 0.0093 0.0366 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0963
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0366 0.0366
Leishmania major cathepsin L-like protease 0.0834 0.4251 0.544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0801
Loa Loa (eye worm) histone deacetylase 11 0.0043 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Echinococcus granulosus cathepsin L cysteine protease 0.0456 0.2266 0.2266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0913 0.2035
Schistosoma mansoni hypothetical protein 0.0169 0.0763 0.0763
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0205 0.0205
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0344 0.0678
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0091 0.0091
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0198 0.0913 0.1976
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.117 0.117
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0801
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0091 0.0091
Echinococcus multilocularis hypothetical protein 0.0586 0.2951 0.2951
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0119 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0066 0.0225 0.0288
Entamoeba histolytica cysteine proteinase, putative 0.0834 0.4251 1
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.02 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0362 0.0362
Giardia lamblia Cathepsin B precursor 0.0198 0.0913 0.226
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Giardia lamblia Cysteine protease 0.0198 0.0913 0.226
Plasmodium vivax hypothetical protein, conserved 0.0035 0.006 0.0141
Echinococcus multilocularis expressed protein 0.0797 0.4055 0.4055
Onchocerca volvulus Glycogen phosphorylase homolog 0.0107 0.0437 0.0559
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0169 0.0169
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0093 0.0366 0.0366
Onchocerca volvulus 0.0159 0.0713 0.0912
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0198 0.0913 0.0913
Trypanosoma brucei centrin, putative 0.0093 0.0366 0.0402
Leishmania major cytochrome p450-like protein 0.0034 0.0054 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0913 0.0913
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.062 0.3126 0.452
Giardia lamblia Cysteine protease 0.0198 0.0913 0.226
Echinococcus granulosus cathepsin L 0.0456 0.2266 0.2266
Echinococcus multilocularis cathepsin L cysteine protease 0.0834 0.4251 0.4251
Plasmodium vivax serine-repeat antigen (SERA) 0.0198 0.0913 0.2148
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0913 0.0913
Onchocerca volvulus 0.0834 0.4251 0.544
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0054 0.0054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0537 0.1573
Loa Loa (eye worm) hypothetical protein 0.1378 0.7103 0.7103
Toxoplasma gondii histone deacetylase HDAC3 0.0089 0.0344 0.044
Giardia lamblia Cathepsin L-like protease 0.0198 0.0913 0.226
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0847 0.1994
Echinococcus granulosus histone deacetylase 1 0.0089 0.0344 0.0344
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0091 0.0091
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2951 0.3733
Entamoeba histolytica prolyl oligopeptidase family protein 0.0185 0.0847 0.1818
Echinococcus granulosus calpain A 0.1649 0.8525 0.8525
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0537 0.1573
Plasmodium falciparum histone deacetylase 2 0.01 0.0402 0.0945
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0456 0.2266 0.2266
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0198 0.0913 0.226
Plasmodium vivax SET domain protein, putative 0.0063 0.0205 0.0481
Trypanosoma cruzi cysteine peptidase, putative 0.0934 0.4778 0.4778
Giardia lamblia Transglutaminase/protease, putative 0.0544 0.2728 0.7259
Trypanosoma cruzi major cysteine proteinase, putative 0.0298 0.144 0.144
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Mycobacterium ulcerans putative transglutaminase-like protein 0.0544 0.2728 0.8705
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0091 0.0091
Leishmania major proteasome beta 2 subunit, putative 0.0041 0.0093 0.0119
Plasmodium falciparum histone deacetylase, putative 0.01 0.0402 0.0945
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0417 0.2063 0.2063
Brugia malayi PXA domain containing protein 0.0041 0.0091 0.0091
Loa Loa (eye worm) calpain D 0.0176 0.0801 0.0801
Trichomonas vaginalis calcineurin B subunit, putative 0.0095 0.0374 0.075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0733 0.3723 0.3723
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0091 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Brugia malayi cathepsin Z-like cysteine proteinase 0.0198 0.0913 0.0913
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.0093 0.0078
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Brugia malayi histone deacetylase 3 (HD3) 0.0089 0.0344 0.0344
Mycobacterium ulcerans proteasome PrcB 0.0086 0.0325 0.0883
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0119 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0091 0.0091
Brugia malayi beta-lactamase family protein 0.0035 0.006 0.006
Schistosoma mansoni Mername-AA248 (C02 family) 0.0586 0.2951 0.2951
Plasmodium falciparum calpain 0.0176 0.0801 0.1884
Echinococcus granulosus Transglutaminase 0.0544 0.2728 0.2728
Plasmodium falciparum peptidase, putative 0.0185 0.0847 0.1994
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0344 0.0678
Trypanosoma brucei protein I/6 0.0093 0.0366 0.0402
Loa Loa (eye worm) hypothetical protein 0.0093 0.0366 0.0366
Onchocerca volvulus 0.0093 0.0366 0.0468
Onchocerca volvulus 0.0052 0.015 0.0192
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0537 0.0537
Echinococcus granulosus acylamino acid releasing enzyme 0.0185 0.0847 0.0847
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0198 0.0913 0.0913
Schistosoma mansoni histone deacetylase 4 5 0.01 0.0402 0.0402
Brugia malayi calpain D 0.0176 0.0801 0.0801
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.0913 0.0913
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Entamoeba histolytica prolyl oligopeptidase family protein 0.0185 0.0847 0.1818
Brugia malayi beta-lactamase family protein 0.0035 0.006 0.006
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0119 0.0066
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.02 0.02
Echinococcus granulosus calpain 5 0.0586 0.2951 0.2951
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0366 0.073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0198 0.0913 0.2035
Mycobacterium tuberculosis Long conserved protein 0.0544 0.2728 0.3934
Leishmania major hypothetical protein, conserved 0.0176 0.0801 0.1025
Echinococcus granulosus calpain 7 C02 family 0.0586 0.2951 0.2951
Leishmania major histone deacetylase, putative 0.0089 0.0344 0.044
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Echinococcus granulosus Dipeptidyl peptidase 9 0.0281 0.1348 0.1348
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2951 0.2951
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0091 0.0091
Brugia malayi Cathepsin L-like precursor 0.0576 0.2898 0.2898
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0281 0.1348 0.1348
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Trypanosoma brucei mitochondrial calcium uptake 1 0.0093 0.0366 0.0402
Loa Loa (eye worm) fibroinase 0.0834 0.4251 0.4251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Giardia lamblia Cysteine protease 0.0198 0.0913 0.226
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0258 0.123 0.123
Giardia lamblia Cathepsin B precursor 0.0733 0.3723 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0135 0.0585 0.0585
Toxoplasma gondii hypothetical protein 0.0176 0.0801 0.1025
Brugia malayi Pre-SET motif family protein 0.0063 0.0205 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0198 0.0913 0.2035
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Onchocerca volvulus 0.0028 0.0025 0.0032
Echinococcus multilocularis Transglutaminase 0.0544 0.2728 0.2728
Echinococcus granulosus neurocalcin 0.0093 0.0366 0.0366
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0091 0.0091
Giardia lamblia Cathepsin L precursor 0.0198 0.0913 0.226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0192 0.0192
Mycobacterium leprae Conserved hypothetical protein 0.0544 0.2728 0.8702
Echinococcus granulosus tumor protein p63 0.0356 0.1747 0.1747
Plasmodium falciparum proteasome subunit beta type-5 0.0086 0.0325 0.0765
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0091 0.0091
Trichomonas vaginalis centrin, putative 0.0093 0.0366 0.073
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0093 0.0366 0.0366
Echinococcus multilocularis calpain 7 (C02 family) 0.0586 0.2951 0.2951
Echinococcus granulosus histone deacetylase 0.01 0.0402 0.0402
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0834 0.4251 0.4251
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0041 0.0093 0.005
Echinococcus multilocularis programmed cell death protein 0.0093 0.0366 0.0366
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.006 0.0008
Giardia lamblia Cysteine protease 0.0198 0.0913 0.226
Leishmania major oligopeptidase b 0.062 0.3126 0.4001
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Loa Loa (eye worm) histone deacetylase 1 0.0089 0.0344 0.0344
Mycobacterium ulcerans transglutaminase family protein 0.0544 0.2728 0.8705
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1647 0.8516 0.8516
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0066 0.0225 0.0225
Toxoplasma gondii preprocathepsin c precursor, putative 0.0198 0.0913 0.1168
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0091 0.0091
Echinococcus granulosus EF hand domain containing family member A2 0.0095 0.0374 0.0374
Leishmania major kinesin, putative 0.041 0.2027 0.2594
Onchocerca volvulus 0.0834 0.4251 0.544
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Giardia lamblia Cathepsin L precursor 0.0198 0.0913 0.226
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0198 0.0913 0.2148
Trichomonas vaginalis set domain proteins, putative 0.0492 0.2457 0.5718
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Echinococcus granulosus microtubule associated protein 2 0.1456 0.7517 0.7517
Echinococcus granulosus caspase 2 0.0062 0.02 0.02
Toxoplasma gondii histone deacetylase HDAC4 0.0043 0.0102 0.0131
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0198 0.0913 0.2148
Onchocerca volvulus 0.0095 0.0374 0.0479
Brugia malayi Trypsin-like protease protein 5 0.0034 0.0057 0.0057
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0093 0.0366 0.0366
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0527 0.2642 0.2642
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0527 0.2642 0.2642
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0091 0.0091
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Leishmania major histone deacetylase, putative 0.01 0.0402 0.0514
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.3777
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.0437 0.0899
Brugia malayi Cathepsin L-like cysteine proteinase 0.0576 0.2898 0.2898
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0963
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0095 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0402 0.1987 0.1987
Loa Loa (eye worm) hypothetical protein 0.0063 0.0205 0.0205
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0198 0.0913 0.2148
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2266 0.5229
Leishmania major centrin, putative,caltractin, putative 0.0093 0.0366 0.0468
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2266 0.5229
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.0913 0.0913
Mycobacterium ulcerans lipase LipD 0.0035 0.006 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0934 0.4778 0.4778
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0834 0.4251 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0198 0.0913 0.0913
Leishmania major hypothetical protein, unknown function 0.0176 0.0801 0.1025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0093 0.0366 0.073
Echinococcus multilocularis caspase 2 0.0062 0.02 0.02
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0086 0.0325 0.0633
Brugia malayi Cathepsin L-like precursor 0.0258 0.123 0.123
Trypanosoma cruzi cysteine proteinase, putative 0.0456 0.2266 0.2266
Loa Loa (eye worm) calpain family protein 1 0.1144 0.5877 0.5877
Loa Loa (eye worm) hypothetical protein 0.0089 0.0344 0.0344
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.2806 0.2806
Loa Loa (eye worm) hypothetical protein 0.006 0.0192 0.0192
Onchocerca volvulus 0.0034 0.0057 0.0073
Echinococcus multilocularis Mastin 0.0034 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0135 0.0585 0.0585
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0176 0.0801 0.0801
Onchocerca volvulus 0.0034 0.0057 0.0073
Trypanosoma cruzi centrin, putative 0.0093 0.0366 0.0366
Entamoeba histolytica hypothetical protein, conserved 0.0095 0.0374 0.0681
Entamoeba histolytica calpain family cysteine protease, putative 0.0176 0.0801 0.1706
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.015 0.015
Echinococcus granulosus cpg binding protein 0.003 0.0033 0.0033
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0091 0.0091
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0801 0.1768
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0913 0.0913
Schistosoma mansoni histone deacetylase 1 2 3 0.0043 0.0102 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.0834 0.4251 1
Brugia malayi hypothetical protein 0.0246 0.117 0.117
Trypanosoma brucei Calpain-like protein 1.1 0.0176 0.0801 0.0963
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.2951
Giardia lamblia Cathepsin L-like protease 0.0198 0.0913 0.226
Trypanosoma brucei Calpain-like protein 2 0.0176 0.0801 0.0963
Trypanosoma cruzi cruzipain precursor, putative 0.0258 0.123 0.123
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0537 0.0537
Plasmodium falciparum serine repeat antigen 9 0.0198 0.0913 0.2148
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0281 0.1348 0.1726
Leishmania major hypothetical protein, conserved 0.0095 0.0374 0.0479
Schistosoma mansoni reticulocalbin 0.0093 0.0366 0.0366
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Brugia malayi Cell death protein 3 precursor 0.0062 0.02 0.02
Echinococcus multilocularis cysteine protease 0.0834 0.4251 0.4251
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0093 0.0366 0.0402
Trichomonas vaginalis calpain, putative 0.0176 0.0801 0.1768
Toxoplasma gondii histone deacetylase HDAC2 0.0089 0.0344 0.044
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0913 0.2035
Echinococcus granulosus cathepsin L cysteine proteinase 0.0834 0.4251 0.4251
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0091 0.0091
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0091 0.0091
Loa Loa (eye worm) ctsf protein 0.0834 0.4251 0.4251
Trypanosoma cruzi oligopeptidase b 0.062 0.3126 0.3126
Schistosoma mansoni cathepsin S (C01 family) 0.0198 0.0913 0.0913
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Schistosoma mansoni centrin-related 0.0093 0.0366 0.0366
Trypanosoma cruzi centrin, putative 0.0093 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0576 0.2898 0.2898
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0537 0.0687
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Onchocerca volvulus 0.0063 0.0205 0.0262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0834 0.4251 1
Giardia lamblia Cathepsin L precursor 0.0198 0.0913 0.226
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0066 0.0225 0.0322
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0344 0.0678
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0362 0.0362
Trypanosoma brucei Calpain-like protein CALP1.3 0.0176 0.0801 0.0963
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.0913 0.2035
Trypanosoma cruzi centrin-3 0.0093 0.0366 0.0366
Onchocerca volvulus Cathepsin L homolog 0.0834 0.4251 0.544
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0198 0.0913 0.2148
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0281 0.1348 0.1668
Loa Loa (eye worm) cathepsin B 0.0733 0.3723 0.3723
Giardia lamblia Cathepsin L precursor 0.0198 0.0913 0.226
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0185 0.0847 0.1879
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.062 0.3126 0.4001
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0198 0.0913 0.0913
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0456 0.2266 0.2266
Echinococcus multilocularis enteropeptidase 0.0034 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0834 0.4251 1
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0086 0.0325 0.0325
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0372 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0456 0.2266 0.2851
Trypanosoma brucei histone deacetylase 3 0.01 0.0402 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.0075
Entamoeba histolytica calmodulin, putative 0.0093 0.0366 0.066
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0095 0.0378 0.0378
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.0366 0.0402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0093 0.0366 0.073
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0119 0.0066
Onchocerca volvulus Cathepsin L homolog 0.0198 0.0913 0.1168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Trichomonas vaginalis hypothetical protein 0.0176 0.0801 0.1768
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.0325 0.0325
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.0057 0.0057
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1987 0.1987
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0135 0.0585 0.0585
Toxoplasma gondii cathepsin B 0.0733 0.3723 0.4765
Leishmania major cathepsin L-like protease 0.0934 0.4778 0.6114
Plasmodium falciparum serine repeat antigen 8 0.0198 0.0913 0.2148
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0135 0.0585 0.0585
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0913 0.2035
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0801 0.0801
Trypanosoma cruzi conserved protein 0.0176 0.0801 0.0801
Schistosoma mansoni cathepsin F (C01 family) 0.0576 0.2898 0.2898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0913 0.2035
Brugia malayi Cathepsin L-like precursor 0.0834 0.4251 0.4251
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1513 0.7815 0.7815
Echinococcus multilocularis EF hand domain containing family member A2 0.0095 0.0374 0.0374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0205 0.0205
Entamoeba histolytica cysteine protease, putative 0.0198 0.0913 0.1976
Loa Loa (eye worm) hypothetical protein 0.0198 0.0913 0.0913
Entamoeba histolytica cysteine protease, putative 0.0198 0.0913 0.1976
Leishmania major proteasome beta 5 subunit, putative 0.0086 0.0325 0.0416
Leishmania major centrin, putative 0.0093 0.0366 0.0468
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0041 0.0093 0.0093
Entamoeba histolytica cysteine proteinase 2 0.0456 0.2266 0.5229
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Schistosoma mansoni cathepsin s 0.0258 0.123 0.123
Trichomonas vaginalis centrin, putative 0.0093 0.0366 0.073
Brugia malayi PXA domain containing protein 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0066 0.0225 0.0225
Giardia lamblia Histone deacetylase 0.0089 0.0344 0.0693
Onchocerca volvulus 0.0034 0.0057 0.0073
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.3777
Toxoplasma gondii histone deacetylase HDAC5 0.0043 0.0103 0.0132
Giardia lamblia Cathepsin B precursor 0.0198 0.0913 0.226
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0091 0.0091
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0258 0.123 0.123
Plasmodium vivax vivapain-1 0.0456 0.2266 0.5331
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.0057 0.0057
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.0057 0.0057
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0801 0.0801
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.062 0.3126 1
Onchocerca volvulus Cathepsin F homolog 0.0834 0.4251 0.544
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0362 0.0362
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.3733
Brugia malayi hypothetical protein 0.0062 0.02 0.02
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.062 0.3126 0.3959
Loa Loa (eye worm) calmodulin-like protein 0.0093 0.0366 0.0366
Trypanosoma cruzi 20S proteasome subunit 0.0041 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0576 0.2898 0.2898
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0054 0.0054
Trypanosoma brucei Aph-1 protein, putative 0.0095 0.0372 0.041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.006 0.002
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0093 0.0366 0.0366
Leishmania major calmodulin, putative 0.0093 0.0366 0.0468
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Loa Loa (eye worm) hypothetical protein 0.0185 0.0847 0.0847
Schistosoma mansoni hypothetical protein 0.0093 0.0366 0.0366
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.006 0.006
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0093 0.0366 0.0366
Toxoplasma gondii hypothetical protein 0.0185 0.0847 0.1085
Mycobacterium tuberculosis Conserved hypothetical protein 0.0544 0.2728 0.3934
Trypanosoma cruzi oligopeptidase b 0.062 0.3126 0.3126
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1647 0.8516 0.8516
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2951 0.2951
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0834 0.4251 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0527 0.2642 0.2642
Schistosoma mansoni cathepsin B (C01 family) 0.0198 0.0913 0.0913
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1647 0.8516 0.8516
Brugia malayi MH2 domain containing protein 0.0127 0.0542 0.0542
Giardia lamblia Cathepsin B precursor 0.0198 0.0913 0.226
Echinococcus granulosus histone deacetylase 6 0.01 0.0402 0.0402
Echinococcus granulosus calumenin 0.0095 0.0374 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0366 0.073
Loa Loa (eye worm) hypothetical protein 0.0135 0.0585 0.0585
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.2806 0.2806
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0913 0.2035
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0066 0.0225 0.0288
Trypanosoma brucei centrin-3 0.0093 0.0366 0.0402
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1513 0.7815 0.7815
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0093 0.0366 0.0366
Mycobacterium tuberculosis Conserved hypothetical protein 0.0544 0.2728 0.3934
Schistosoma mansoni histone deacetylase 0.0089 0.0344 0.0344
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0185 0.0847 0.1818
Schistosoma mansoni hypothetical protein 0.0093 0.0366 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0963
Echinococcus multilocularis calbindin 32 0.0095 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.1144 0.5877 0.5877
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Brugia malayi Papain family cysteine protease containing protein 0.0456 0.2266 0.2266
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0366 0.073
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0091 0.0091
Echinococcus granulosus calcium uptake protein 1 0.0095 0.0374 0.0374
Brugia malayi Cathepsin L-like precursor 0.0834 0.4251 0.4251
Brugia malayi Thioredoxin family protein 0.0544 0.2728 0.2728
Trypanosoma brucei hypothetical protein 0.0176 0.0801 0.0963
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0847 0.1879
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0834 0.4251 0.4251
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0091 0.0091
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0542 0.0542
Plasmodium vivax unspecified product 0.0258 0.123 0.2893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0913 0.2035
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0198 0.0913 0.2148
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.0437 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.006
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0198 0.0913 0.2148
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0544 0.2728 0.2728
Echinococcus multilocularis calmodulin 0.0093 0.0366 0.0366
Trypanosoma brucei prolyl endopeptidase 0.1513 0.7815 1
Schistosoma mansoni rab 0.0093 0.0366 0.0366
Onchocerca volvulus 0.0034 0.0057 0.0073
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0041 0.0093 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1987 0.1987
Leishmania major cathepsin L-like protease 0.0834 0.4251 0.544
Leishmania major calmodulin-like protein 0.0093 0.0366 0.0468
Loa Loa (eye worm) calpain family protein 1 0.1554 0.8027 0.8027
Trypanosoma brucei caltractin, putative 0.0093 0.0366 0.0402
Echinococcus granulosus cathepsin l cysteine peptidase 0.0834 0.4251 0.4251
Echinococcus multilocularis Glycosyl transferase, family 35 0.0107 0.0437 0.0437
Brugia malayi Papain family cysteine protease containing protein 0.0834 0.4251 0.4251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Schistosoma mansoni histone deacetylase 4 5 0.01 0.0402 0.0402
Trypanosoma brucei histone deacetylase, putative 0.01 0.0402 0.0448
Echinococcus granulosus histone deacetylase 7 0.01 0.0402 0.0402
Brugia malayi Cytochrome P450 family protein 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0159 0.0713 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.0075
Toxoplasma gondii troponin c, isotype gamma, putative 0.0093 0.0366 0.0468
Schistosoma mansoni gamma-secretase subunit aph-1 0.0243 0.1149 0.1149
Entamoeba histolytica cysteine protease, putative 0.0198 0.0913 0.1976
Trypanosoma cruzi cysteine peptidase, putative 0.0456 0.2266 0.2266
Plasmodium falciparum centrin-1 0.0093 0.0366 0.086
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0091 0.0091
Brugia malayi hypothetical protein 0.0041 0.0091 0.0091
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0801 0.0963
Echinococcus granulosus neuropeptide s receptor 0.0558 0.2806 0.2806
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0246 0.117 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.0075
Giardia lamblia Alanyl dipeptidyl peptidase 0.0185 0.0847 0.2079
Leishmania major cathepsin L-like protease 0.0834 0.4251 0.544
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Leishmania major cathepsin L-like protease 0.0934 0.4778 0.6114
Brugia malayi proteasome subunit beta type 1 0.0066 0.0225 0.0225
Brugia malayi cathepsin F-like cysteine proteinase 0.0198 0.0913 0.0913
Echinococcus multilocularis acylamino acid releasing enzyme 0.0185 0.0847 0.0847
Schistosoma mansoni centrin 0.0093 0.0366 0.0366
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.2806 0.2806
Trypanosoma brucei histone deacetylase 2 0.0043 0.0102 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2898 0.6771
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0091 0.0091
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0091 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2266 0.5229
Loa Loa (eye worm) hypothetical protein 0.0576 0.2898 0.2898
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.2898 0.6747
Schistosoma mansoni glycogen phosphorylase 0.0107 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0198 0.0913 0.0913
Plasmodium vivax histone deacetylase 1, putative 0.0089 0.0344 0.081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0537 0.0687
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0801
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1554 0.8027 0.8027
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0176 0.0801 0.0963
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0091 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0963
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0834 0.4251 0.4251
Trypanosoma cruzi I/6 autoantigen, putative 0.0093 0.0366 0.0366
Echinococcus granulosus glycogen phosphorylase 0.0107 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.1513 0.7815 0.7815
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.0437 0.0899
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Brugia malayi EF hand family protein 0.0095 0.0374 0.0374
Brugia malayi cathepsin L precursor 0.0198 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0093 0.0366 0.0366
Trypanosoma cruzi cysteine peptidase, putative 0.0834 0.4251 0.4251
Plasmodium falciparum cysteine proteinase falcipain 3 0.0834 0.4251 1
Echinococcus multilocularis microtubule associated protein 2 0.1456 0.7517 0.7517
Schistosoma mansoni mitochondrial solute carrier 0.0093 0.0366 0.0366
Brugia malayi EF hand family protein 0.0093 0.0366 0.0366
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0456 0.2266 0.2851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1647 0.8516 0.8516
Giardia lamblia Alanyl dipeptidyl peptidase 0.0185 0.0847 0.2079
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0119 0.0211
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0198 0.0913 0.0913
Trypanosoma brucei kinesin, putative 0.041 0.2027 0.2542
Echinococcus granulosus inhibitor of apoptosis protein 0.0135 0.0585 0.0585
Entamoeba histolytica histone deacetylase, putative 0.0089 0.0344 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0119 0.0119
Echinococcus multilocularis gamma secretase subunit aph 1 0.0243 0.1149 0.1149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Brugia malayi calcium-binding protein 0.0093 0.0366 0.0366
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0192 0.0192
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Plasmodium falciparum serine repeat antigen 3 0.0198 0.0913 0.2148
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0093 0.0366 0.066
Trypanosoma brucei cysteine peptidase C (CPC) 0.0733 0.3723 0.4728
Trypanosoma cruzi prolyl endopeptidase 0.1513 0.7815 0.7815
Echinococcus granulosus Glycosyl transferase family 35 0.0107 0.0437 0.0437
Giardia lamblia Encystation-specific protease 0.0198 0.0913 0.226
Brugia malayi calpain 5 0.0176 0.0801 0.0801
Schistosoma mansoni calmodulin 0.0093 0.0366 0.0366
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0192 0.0192
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.117 0.117
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0066 0.0225 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2266 0.5229
Loa Loa (eye worm) hypothetical protein 0.0185 0.0847 0.0847
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0086 0.0325 0.035
Brugia malayi calpain family protein 1 0.1554 0.8027 0.8027
Trypanosoma cruzi calmodulin, putative 0.0093 0.0366 0.0366
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0041 0.0093 0.0119
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0537 0.0537
Echinococcus granulosus cathepsin l1 0.0834 0.4251 0.4251
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0801 0.0801
Onchocerca volvulus Deterin homolog 0.0135 0.0585 0.0749
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0198 0.0913 0.2148
Onchocerca volvulus 0.0034 0.0057 0.0073
Leishmania major calmodulin-like protein 0.0093 0.0366 0.0468
Loa Loa (eye worm) hypothetical protein 0.0258 0.123 0.123
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0057 0.0057
Onchocerca volvulus 0.0034 0.0057 0.0073
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0091 0.0091
Schistosoma mansoni reticulocalbin 0.0095 0.0374 0.0374
Leishmania major cathepsin L-like protease 0.0834 0.4251 0.544
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0198 0.0913 0.226
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0801
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0093 0.0366 0.066
Trypanosoma cruzi calmodulin, putative 0.0093 0.0366 0.0366
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0258 0.123 0.123
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.0325 0.0325
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0366 0.073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Entamoeba histolytica cysteine protease, putative 0.0834 0.4251 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Onchocerca volvulus 0.0062 0.02 0.0255
Echinococcus multilocularis cathepsin L 0.0198 0.0913 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2898 0.6771
Brugia malayi Cathepsin L-like precursor 0.0576 0.2898 0.2898
Toxoplasma gondii EFHC1, putative 0.0093 0.0366 0.0468
Trypanosoma cruzi cysteine peptidase, putative 0.0934 0.4778 0.4778
Plasmodium falciparum cysteine proteinase falcipain 1 0.0456 0.2266 0.5331
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2951 0.3733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Toxoplasma gondii histone deacetylase HDAC1 0.01 0.0402 0.0514
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.006 0.006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.0913 0.0913
Echinococcus multilocularis calmodulin 0.0093 0.0366 0.0366
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.062 0.3126 0.3126
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0093 0.0366 0.0366
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0402 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.0075
Entamoeba histolytica cysteine protease, putative 0.0198 0.0913 0.1976
Giardia lamblia Hypothetical protein 0.0544 0.2728 0.7259
Echinococcus multilocularis histone deacetylase 6 0.0106 0.0435 0.0435
Loa Loa (eye worm) calpain 0.0586 0.2951 0.2951
Giardia lamblia Hypothetical protein 0.0095 0.0374 0.0776
Brugia malayi Papain family cysteine protease containing protein 0.0456 0.2266 0.2266
Brugia malayi Proteasome A-type and B-type family protein 0.0086 0.0325 0.0325
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0537 0.0703
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2951 0.3733
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0102 0.0102
Schistosoma mansoni calpain (C02 family) 0.0586 0.2951 0.2951
Brugia malayi cathepsin L-like cysteine proteinase 0.0198 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0258 0.123 0.123
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.3777
Leishmania major histone deacetylase, putative 0.0089 0.0344 0.044
Plasmodium vivax calpain, putative 0.0586 0.2951 0.6942
Brugia malayi Cytochrome P450 family protein 0.0034 0.0054 0.0054
Trypanosoma cruzi caltractin, putative 0.0093 0.0366 0.0366
Mycobacterium tuberculosis Conserved protein 0.0544 0.2728 0.3934
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0374 0.0881
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0205 0.0205
Leishmania major cathepsin L-like protease 0.0834 0.4251 0.544
Echinococcus granulosus cathepsin L 0.0198 0.0913 0.0913
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0086 0.0325 0.0641
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.0437 0.0831
Echinococcus granulosus enteropeptidase 0.0034 0.0057 0.0057
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0733 0.3723 0.4765
Entamoeba histolytica calpain large subunit domain III containing protein 0.041 0.2027 0.4653
Trichomonas vaginalis calmodulin-2, putative 0.0093 0.0366 0.073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0057
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0176 0.0801 0.1025
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0091 0.0091
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0366 0.0366
Echinococcus granulosus geminin 0.0169 0.0763 0.0763
Entamoeba histolytica cysteine proteinase 1, putative 0.0456 0.2266 0.5229
Loa Loa (eye worm) histone deacetylase 3 0.0089 0.0344 0.0344
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0185 0.0847 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0913 0.2035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0456 0.2266 0.5264
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0198 0.0913 0.2035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0362 0.0362
Brugia malayi hypothetical protein 0.0159 0.0713 0.0713
Schistosoma mansoni calpain-7 (C02 family) 0.0589 0.2967 0.2967
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Plasmodium falciparum serine repeat antigen 4 0.0198 0.0913 0.2148
Trypanosoma cruzi kinesin, putative 0.041 0.2027 0.2027
Plasmodium vivax unspecified product 0.0456 0.2266 0.5331
Echinococcus multilocularis histone deacetylase 1 0.0089 0.0344 0.0344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.006 0.006
Trypanosoma brucei cysteine peptidase, putative 0.0176 0.0801 0.0963
Brugia malayi histone deacetylase 1 (HD1) 0.0089 0.0344 0.0344
Toxoplasma gondii centrin, putative 0.0093 0.0366 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0091 0.0091
Leishmania major histone deacetylase, putative 0.01 0.0402 0.0514
Echinococcus granulosus glycogen phosphorylase 0.0107 0.0437 0.0437
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0086 0.0325 0.0563
Brugia malayi programmed cell death protein 6 0.0093 0.0366 0.0366
Brugia malayi carbohydrate phosphorylase 0.0107 0.0437 0.0437
Echinococcus multilocularis cysteine protease 0.0834 0.4251 0.4251
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0057
Loa Loa (eye worm) histone deacetylase 0.01 0.0402 0.0402
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0801 0.0801
Toxoplasma gondii ABC1 family protein 0.0035 0.006 0.0077
Brugia malayi cathepsin F-like cysteine proteinase 0.0258 0.123 0.123
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0169 0.0763 0.0763
Plasmodium vivax histone deacetylase, putative 0.0043 0.0102 0.024
Mycobacterium ulcerans hypothetical protein 0.0035 0.006 0.002
Loa Loa (eye worm) calpain 5 0.041 0.2027 0.2027
Giardia lamblia Proteasome subunit beta type 1 0.0066 0.0225 0.0365
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0185 0.0847 0.0847
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0066 0.0225 0.0225
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0366 0.0366
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0025 0.0025
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0198 0.0913 0.2148
Trypanosoma brucei I/6 autoantigen 0.0093 0.0366 0.0402
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.0913 0.0913
Trypanosoma cruzi histone deacetylase 1, putative 0.0089 0.0344 0.0344
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Echinococcus granulosus neuronal calcium sensor 0.0093 0.0366 0.0366
Leishmania major calpain family cysteine protease-like protein 0.0176 0.0801 0.1025
Schistosoma mansoni calmodulin 0.0093 0.0366 0.0366
Brugia malayi Histone deacetylase family protein 0.01 0.0402 0.0402
Toxoplasma gondii cathepsin CPL 0.0834 0.4251 0.544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0913 0.2035
Trypanosoma brucei calpain, putative 0.0176 0.0801 0.0963
Plasmodium vivax serine-repeat antigen (SERA) 0.0198 0.0913 0.2148
Entamoeba histolytica grainin 2 0.0093 0.0366 0.066
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Echinococcus multilocularis programmed cell death protein 0.0093 0.0366 0.0366
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0066 0.0225 0.0225
Entamoeba histolytica grainin, putative 0.0095 0.0374 0.0681
Toxoplasma gondii calmodulin CAM1 0.0095 0.0374 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Giardia lamblia Cathepsin L precursor 0.0198 0.0913 0.226
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0041 0.0093 0.0093
Echinococcus multilocularis histone deacetylase 8 0.0043 0.0102 0.0102
Brugia malayi prolyl oligopeptidase family protein 0.0281 0.1348 0.1348
Trypanosoma cruzi histone deacetylase 1, putative 0.0089 0.0344 0.0344
Echinococcus granulosus prolyl endopeptidase 0.1513 0.7815 0.7815
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.015
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.02 0.02
Echinococcus multilocularis histone deacetylase 6 0.01 0.0402 0.0402
Mycobacterium leprae Conserved hypothetical protein 0.0544 0.2728 0.8702
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0913 0.0913
Plasmodium vivax proteasome subunit beta type-2, putative 0.0041 0.0093 0.0218
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0198 0.0913 0.2035
Giardia lamblia Hypothetical protein 0.0198 0.0913 0.226
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Echinococcus multilocularis centrin 2 0.0093 0.0366 0.0366
Loa Loa (eye worm) histone deacetylase 7A 0.01 0.0402 0.0402
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.0913 0.0913
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.0437 0.0831
Trypanosoma brucei proteasome beta 6 subunit 0.0066 0.0225 0.0221
Echinococcus multilocularis calcium uptake protein 1 0.0095 0.0374 0.0374
Echinococcus multilocularis calpain 5 0.0586 0.2951 0.2951
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0066 0.0225 0.0394
Echinococcus granulosus histone deacetylase 8 0.0043 0.0102 0.0102
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2951 0.2951
Toxoplasma gondii proteasome subunit beta type, putative 0.0086 0.0325 0.0416
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Brugia malayi Histone deacetylase family protein 0.01 0.0402 0.0402
Giardia lamblia Cathepsin L precursor 0.0198 0.0913 0.226
Onchocerca volvulus 0.0834 0.4251 0.544
Echinococcus multilocularis cathepsin L cysteine protease 0.0834 0.4251 0.4251
Loa Loa (eye worm) hypothetical protein 0.0834 0.4251 0.4251
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0847 0.0847
Brugia malayi prolyl oligopeptidase family protein 0.1513 0.7815 0.7815
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.014 0.014
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0417 0.2063 0.2063
Echinococcus multilocularis inhibitor of apoptosis protein 0.0135 0.0585 0.0585
Trypanosoma cruzi cysteine protease, putative 0.0456 0.2266 0.2266
Trichomonas vaginalis calpain, putative 0.0176 0.0801 0.1768
Onchocerca volvulus 0.0732 0.3718 0.4758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Schistosoma mansoni histone deacetylase 0.0089 0.0344 0.0344
Giardia lamblia Cathepsin B precursor 0.0198 0.0913 0.226
Brugia malayi fibroinase precursor 0.0198 0.0913 0.0913
Onchocerca volvulus 0.0834 0.4251 0.544
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0091 0.0091
Trichomonas vaginalis calcium binding proteins, putative 0.0093 0.0366 0.073
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0093 0.0366 0.086
Schistosoma mansoni ef hand domain family member A2 0.0093 0.0366 0.0366
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0801 0.1768
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.2951
Brugia malayi Cathepsin L-like precursor 0.0834 0.4251 0.4251
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0198 0.0913 0.2148
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0041 0.0093 0.0093
Loa Loa (eye worm) proteasome subunit beta type 1 0.0066 0.0225 0.0225
Schistosoma mansoni calpain C (C02 family) 0.0586 0.2951 0.2951
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0198 0.0913 0.2148
Echinococcus granulosus cathepsin l1 0.0576 0.2898 0.2898
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0913 0.2035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0185 0.0847 0.1879
Onchocerca volvulus 0.0834 0.4251 0.544
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0093 0.0366 0.0366
Leishmania major i/6 autoantigen-like protein 0.0093 0.0366 0.0468
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1328 0.6844 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0091 0.0091
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Brugia malayi Cathepsin L-like precursor 0.0834 0.4251 0.4251
Brugia malayi hypothetical protein 0.0041 0.0091 0.0091
Plasmodium falciparum serine repeat antigen 1 0.0198 0.0913 0.2148
Echinococcus granulosus histone deacetylase 3 0.0089 0.0344 0.0344
Schistosoma mansoni cathepsin F (C01 family) 0.0834 0.4251 0.4251
Onchocerca volvulus 0.0492 0.2458 0.3145
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0733 0.3723 0.8741
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Leishmania major centrin, putative 0.0093 0.0366 0.0468
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.006 0.006
Echinococcus multilocularis EF hand domain containing family member A2 0.0093 0.0366 0.0366
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0091 0.0091
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0185 0.0847 0.1085
Onchocerca volvulus 0.0198 0.0913 0.1168
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0362 0.0362
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0091 0.0091
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0091 0.0075
Giardia lamblia Cathepsin B precursor 0.0198 0.0913 0.226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Schistosoma mansoni cpg binding protein 0.0028 0.0025 0.0025
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0527 0.2642 0.2642
Trypanosoma brucei antigen, putative 0.0586 0.2951 0.3733
Entamoeba histolytica protein kinase, putative 0.041 0.2027 0.4653
Mycobacterium tuberculosis Hypothetical protein 0.0544 0.2728 0.3934
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Trichomonas vaginalis peptide N-glycanase, putative 0.0544 0.2728 0.6367
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.0075
Loa Loa (eye worm) hypothetical protein 0.0968 0.4953 0.4953
Leishmania major cysteine peptidase A (CPA) 0.0834 0.4251 0.544
Trypanosoma cruzi cysteine proteinase, putative 0.0456 0.2266 0.2266
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.0075
Loa Loa (eye worm) hypothetical protein 0.0198 0.0913 0.0913
Schistosoma mansoni hypothetical protein 0.0176 0.0801 0.0801
Toxoplasma gondii cathepsin CPC1 0.0198 0.0913 0.1168
Plasmodium vivax vivapain-3 0.0456 0.2266 0.5331
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0198 0.0913 0.0913
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0135 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Brugia malayi gamma-secretase subunit aph-1 0.0243 0.1149 0.1149
Brugia malayi Cathepsin L-like precursor 0.0834 0.4251 0.4251
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0913 0.2035
Echinococcus multilocularis calpain A 0.1649 0.8525 0.8525
Giardia lamblia Glycogen phosphorylase 0.0107 0.0437 0.0948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0362 0.0362
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0091 0.0091
Brugia malayi calpain 7 0.0586 0.2951 0.2951
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.4251 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0205 0.0262
Entamoeba histolytica calcium-binding protein, putative 0.0093 0.0366 0.066
Echinococcus granulosus expressed protein 0.0797 0.4055 0.4055
Echinococcus granulosus gamma secretase subunit aph 1 0.0243 0.1149 0.1149
Schistosoma mansoni glycogen phosphorylase 0.0107 0.0437 0.0437
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0091 0.0091
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0417 0.2063 0.2063
Schistosoma mansoni hypothetical protein 0.0062 0.02 0.02
Mycobacterium ulcerans hypothetical protein 0.0544 0.2728 0.8705
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0091 0.0091
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0091 0.0091
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0676 0.3425 0.3425
Echinococcus multilocularis cpg binding protein 0.003 0.0033 0.0033
Trypanosoma cruzi calmodulin, putative 0.0093 0.0366 0.0366
Plasmodium falciparum serine repeat antigen 7 0.0198 0.0913 0.2148
Trypanosoma brucei histone deacetylase 4 0.01 0.0402 0.0448
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0366 0.073
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0281 0.1348 0.1668
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0456 0.2266 0.2266
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0066 0.0225 0.053
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0366 0.073
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0281 0.1348 0.1348
Brugia malayi proteasome subunit beta type 2 0.0041 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Loa Loa (eye worm) programmed cell death protein 6 0.0095 0.0374 0.0374
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Echinococcus multilocularis cathepsin L 0.0456 0.2266 0.2266
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Echinococcus multilocularis histone deacetylase 7 0.01 0.0402 0.0402
Giardia lamblia Cathepsin B precursor 0.0733 0.3723 1
Trypanosoma brucei centrin, putative 0.0093 0.0366 0.0402
Brugia malayi histone deacetylase 11 0.0043 0.0102 0.0102
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.0093 0.0093
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0344 0.0678
Brugia malayi prolyl oligopeptidase family protein 0.0185 0.0847 0.0847
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0086 0.0325 0.0325
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0091 0.0091
Schistosoma mansoni survival motor neuron protein 0.005 0.014 0.014
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0086 0.0325 0.0865
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Mycobacterium ulcerans beta-lactamase 0.0035 0.006 0.002
Trypanosoma brucei Calpain-like protein 1.2 0.0176 0.0801 0.0963
Schistosoma mansoni memapsin-2 (A01 family) 0.0444 0.2206 0.2206
Schistosoma mansoni calpain-7 (C02 family) 0.0589 0.2967 0.2967
Loa Loa (eye worm) hypothetical protein 0.0062 0.02 0.02
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0135 0.0585 0.0585
Schistosoma mansoni calpain-2 (C02 family) 0.0176 0.0801 0.0801
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.0801
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.0913 0.2035
Mycobacterium ulcerans hypothetical protein 0.0544 0.2728 0.8705
Brugia malayi Cathepsin L-like precursor 0.0834 0.4251 0.4251
Echinococcus granulosus calbindin 32 0.0095 0.0374 0.0374
Loa Loa (eye worm) beta-lactamase 0.0035 0.006 0.006
Brugia malayi hypothetical protein 0.0034 0.0057 0.0057
Plasmodium vivax centrin-1, putative 0.0093 0.0366 0.086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0362 0.0362
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0169 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.0801 0.1768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Onchocerca volvulus 0.0035 0.006 0.0077
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.0057 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0847 0.0847
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0063 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0801 0.1768
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0281 0.1348 0.1348
Trypanosoma brucei Component of motile flagella 41 0.0093 0.0366 0.0402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Brugia malayi hypothetical protein 0.0095 0.0378 0.0378
Echinococcus multilocularis tumor protein p63 0.0356 0.1747 0.1747
Brugia malayi prolyl oligopeptidase family protein 0.0185 0.0847 0.0847
Plasmodium vivax vivapain-2 0.0834 0.4251 1
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.0057 0.0057
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0093 0.0366 0.0402
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0913 0.2035
Loa Loa (eye worm) hypothetical protein 0.1554 0.8027 0.8027
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.2144 0.2144
Trichomonas vaginalis calmodulin, putative 0.0093 0.0366 0.073
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0057
Echinococcus multilocularis calpain 0.0586 0.2951 0.2951
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0057
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0091 0.0091
Onchocerca volvulus Cathepsin L homolog 0.0834 0.4251 0.544
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.2951
Mycobacterium ulcerans hypothetical protein 0.0034 0.0057 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.123 0.123
Entamoeba histolytica calmodulin, putative 0.0093 0.0366 0.066
Entamoeba histolytica calcium binding family protein 0.0093 0.0366 0.066
Trypanosoma brucei histone deacetylase 1 0.0089 0.0344 0.0374
Loa Loa (eye worm) hypothetical protein 0.0198 0.0913 0.0913
Brugia malayi Cytochrome P450 family protein 0.0056 0.0169 0.0169
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0135 0.0585 0.0585
Leishmania major calpain protease-like protein 0.0176 0.0801 0.1025
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0344 0.0678
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2951 0.2951
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.006 0.006
Leishmania major hypothetical protein, conserved 0.0035 0.006 0.0077
Echinococcus granulosus Mastin 0.0034 0.0057 0.0057
Entamoeba histolytica cysteine protease, putative 0.0456 0.2266 0.5229
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0205 0.0205
Leishmania major cathepsin L-like protease 0.0934 0.4778 0.6114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.4251 1
Echinococcus multilocularis histone deacetylase 3 0.0089 0.0344 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.006
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0344 0.0678
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0176
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0834 0.4251 0.4251
Leishmania major calmodulin, putative 0.0093 0.0366 0.0468
Toxoplasma gondii centrin 0.0093 0.0366 0.0468
Plasmodium vivax proteasome subunit beta type-5, putative 0.0086 0.0325 0.0765
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0041 0.0093 0.0218
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0801 0.1025
Giardia lamblia Cathepsin B precursor 0.0733 0.3723 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4778 0.6087
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0135 0.0585 0.0585
Plasmodium vivax vivapain-2 0.0834 0.4251 1
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.0437 0.0437
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0198 0.0913 0.2148
Plasmodium vivax unspecified product 0.0198 0.0913 0.2148
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0091 0.0091
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.062 0.3126 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0198 0.0913 0.226

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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