Detailed information for compound 1414534

Basic information

Technical information
  • TDR Targets ID: 1414534
  • Name: ZINC01145873
  • MW: 482.549 | Formula: C25H26N2O6S
  • H donors: 1 H acceptors: 4 LogP: 4.09 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)CN(S(=O)(=O)c1ccc(cc1)OC)c1ccc(cc1)C
  • InChi: 1S/C25H26N2O6S/c1-4-33-25(29)19-7-9-20(10-8-19)26-24(28)17-27(21-11-5-18(2)6-12-21)34(30,31)23-15-13-22(32-3)14-16-23/h5-16H,4,17H2,1-3H3,(H,26,28)
  • InChiKey: POAUQVNWBSEBIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCGC00099845-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1682 0.1966
Echinococcus multilocularis transcription factor collier 0.016 0.0247 0.0241
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0066 0.0047 0.0012
Trypanosoma cruzi aurora B kinase, putative 0.008 0.0077 0.5919
Loa Loa (eye worm) hypothetical protein 0.0365 0.0684 0.0651
Onchocerca volvulus 0.0859 0.1737 1
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.1543 1
Schistosoma mansoni hypothetical protein 0.007 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0365 0.0684 0.0651
Trichomonas vaginalis AGC family protein kinase 0.008 0.0077 0.02
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0768 0.1543 0.1799
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0057 0.0067
Echinococcus multilocularis pdz domain containing protein 0.007 0.0057 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0047 0.0047
Giardia lamblia Aurora kinase 0.008 0.0077 1
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0057 0.1986
Trypanosoma brucei PH domain containing protein, putative 0.007 0.0057 0.1986
Echinococcus multilocularis pleckstrin y domain containing family A 0.007 0.0057 0.0012
Onchocerca volvulus Protein melted homolog 0.007 0.0057 0.0059
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Schistosoma mansoni goodpasture antigen-binding protein 0.007 0.0057 0.0057
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3969 0.8364 0.8358
Leishmania major protein kinase, putative 0.0089 0.0098 1
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3969 0.8364 1
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.023 0.0398 0.0352
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Echinococcus multilocularis Pleckstrin y 0.007 0.0057 0.0012
Onchocerca volvulus 0.007 0.0057 0.0059
Loa Loa (eye worm) hypothetical protein 0.0262 0.0464 0.0431
Schistosoma mansoni regulator of G protein signaling 0.0768 0.1543 0.1543
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Entamoeba histolytica hypothetical protein 0.007 0.0057 0.0067
Schistosoma mansoni zinc finger protein 0.007 0.0057 0.0057
Echinococcus granulosus regulator of G protein signaling 3 0.0768 0.1543 0.1799
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Schistosoma mansoni centaurin alpha 0.007 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Brugia malayi Oxysterol-binding protein 0.007 0.0057 0.001
Schistosoma mansoni ephrin receptor 0.0066 0.0047 0.0047
Loa Loa (eye worm) cytohesin 3 0.007 0.0057 0.0022
Schistosoma mansoni z-protein (S1r protein) 0.0768 0.1543 0.1543
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.1543 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0085 0.0088 0.8014
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) hypothetical protein 0.016 0.0247 0.0213
Leishmania major serine/threonine-protein kinase a, putative 0.0089 0.0098 1
Schistosoma mansoni plexin 0.0494 0.096 0.096
Schistosoma mansoni hypothetical protein 0.007 0.0057 0.0057
Toxoplasma gondii hypothetical protein 0.007 0.0057 0.1986
Leishmania major folate/biopterin transporter, putative 0.0089 0.0098 1
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Echinococcus multilocularis GRB2 associated binding protein 3 0.007 0.0057 0.0012
Entamoeba histolytica PH domain containing protein 0.007 0.0057 0.0067
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Loa Loa (eye worm) plexin A 0.1019 0.2077 0.2049
Echinococcus granulosus oxysterol binding protein 1 0.007 0.0057 0.0012
Plasmodium vivax conserved Plasmodium protein, unknown function 0.007 0.0057 0.1986
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica hypothetical protein 0.007 0.0057 0.0067
Loa Loa (eye worm) RGC/RGC protein kinase 0.0066 0.0047 0.0012
Trichomonas vaginalis centaurin/arf, putative 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Leishmania major hypothetical protein, conserved 0.007 0.0057 0.1986
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Trypanosoma brucei aurora B kinase 0.008 0.0077 0.5919
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.008 0.0077 0.02
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0773 0.1554 0.1524
Schistosoma mansoni regulator of G protein signaling 0.0768 0.1543 0.1543
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0089 0.0098 1
Loa Loa (eye worm) SRC-1 0.0066 0.0047 0.0012
Trypanosoma cruzi NIMA-related kinase, putative 0.0089 0.0098 1
Schistosoma mansoni serine/threonine-protein kinase 0.0089 0.0098 0.0098
Loa Loa (eye worm) AUR protein kinase 0.008 0.0077 0.0042
Schistosoma mansoni hypothetical protein 0.016 0.0247 0.0247
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Entamoeba histolytica hypothetical protein 0.0089 0.0098 0.0337
Echinococcus granulosus regulator of G protein signaling 3 0.0768 0.1543 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0085 0.0088 0.0049
Loa Loa (eye worm) TK/ACK protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.0365 0.0684 0.0651
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0057 0.1986
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0071 0.0058 0.0013
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.023 0.0398 0.0364
Echinococcus granulosus roundabout 2 0.0266 0.0475 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Echinococcus multilocularis aurora kinase A 0.008 0.0077 0.0036
Schistosoma mansoni axis inhibition protein axin 0.0768 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0859 0.1737 0.1708
Entamoeba histolytica hypothetical protein 0.0768 0.1543 1
Trypanosoma brucei protein kinase, putative 0.0085 0.0088 0.8014
Echinococcus multilocularis calcium dependent secretion activator 1 0.007 0.0057 0.0012
Echinococcus granulosus beta-adrenergic receptor kinase 0.3631 0.7643 0.9134
Echinococcus multilocularis axis inhibition protein axin 0.0768 0.1543 0.1799
Onchocerca volvulus 0.007 0.0057 0.0059
Plasmodium falciparum serine/threonine protein kinase, putative 0.008 0.0077 0.5919
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0089 0.0098 1
Schistosoma mansoni cell adhesion molecule 0.0251 0.0441 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Loa Loa (eye worm) hypothetical protein 0.016 0.0247 0.0213
Loa Loa (eye worm) hypothetical protein 0.0768 0.1543 0.1514
Echinococcus granulosus regulator of G protein signaling 7 0.0768 0.1543 0.1799
Loa Loa (eye worm) hypothetical protein 0.0768 0.1543 0.1514
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) hypothetical protein 0.0246 0.043 0.0397
Echinococcus granulosus axis inhibition protein axin 0.0768 0.1543 0.1799
Loa Loa (eye worm) hypothetical protein 0.0223 0.0382 0.0348
Echinococcus multilocularis regulator of G protein signaling 7 0.0768 0.1543 0.1799
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0066 0.0047 0.0047
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0247 0.1338
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0057 0.1986
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Brugia malayi Uncoordinated protein 104 0.007 0.0057 0.001
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.007 0.0057 0.0012
Echinococcus multilocularis exocyst complex component 2 0.016 0.0247 0.0241
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.007 0.0057 0.0067
Echinococcus granulosus dynamin 1 0.007 0.0057 0.0012
Schistosoma mansoni hypothetical protein 0.016 0.0247 0.0247
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0057 0.1986
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3969 0.8364 0.8358
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.1543 1
Echinococcus granulosus myotubularin protein 13 0.007 0.0057 0.0012
Schistosoma mansoni syntrophin 0.007 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0066 0.0047 0.0047
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0089 0.0098 1
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.007 0.0057 0.0067
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2863 0.6007 0.7166
Entamoeba histolytica tyrosin kinase, putative 0.0225 0.0387 0.2274
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.007 0.0057 0.1986
Echinococcus granulosus Pleckstrin y 0.007 0.0057 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0057 0.0067
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0089 0.0098 1
Echinococcus multilocularis activin receptor type 0.0085 0.0088 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Brugia malayi hypothetical protein 0.023 0.0398 0.0352
Schistosoma mansoni myotubularin-related protein 0.007 0.0057 0.0057
Trichomonas vaginalis protein transport protein sec7, putative 0.007 0.0057 0.0067
Trichomonas vaginalis centaurin gamma, putative 0.007 0.0057 0.0067
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0773 0.1554 0.1514
Echinococcus granulosus Pleckstrin y 0.007 0.0057 0.0012
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0085 0.0088 0.8014
Toxoplasma gondii protein kinase domain-containing protein 0.0089 0.0098 1
Schistosoma mansoni serine/threonine protein kinase 0.3631 0.7643 0.7643
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Echinococcus multilocularis expressed protein 0.0768 0.1543 0.1799
Echinococcus multilocularis actin binding protein anillin 0.007 0.0057 0.0012
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.007 0.0057 0.0012
Echinococcus granulosus expressed protein 0.0768 0.1543 0.1799
Schistosoma mansoni serine/threonine protein kinase 0.4738 1 1
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Schistosoma mansoni ephrin receptor 0.0071 0.0058 0.0058
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0089 0.0098 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Echinococcus granulosus transcription factor collier 0.016 0.0247 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1682 0.1682
Entamoeba histolytica hypothetical protein, conserved 0.007 0.0057 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Brugia malayi Protein kinase domain containing protein 0.0319 0.0587 0.0542
Loa Loa (eye worm) TK protein kinase 0.0082 0.0081 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0768 0.1543 0.1543
Echinococcus granulosus Regulator of G protein signaling 20 0.0768 0.1543 0.1799
Echinococcus granulosus plexin a4 0.1019 0.2077 0.2441
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3631 0.7643 0.7635
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Brugia malayi hypothetical protein 0.0365 0.0684 0.064
Schistosoma mansoni oxysterol-binding protein 1 0.007 0.0057 0.0057
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.007 0.0057 0.0012
Trichomonas vaginalis hypothetical protein 0.007 0.0057 0.0067
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0225 0.0387 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.1543 1
Schistosoma mansoni semaphorin 5-related 0.0365 0.0684 0.0684
Echinococcus granulosus serine:threonine protein kinase 12 B 0.008 0.0077 0.0036
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0098 0.0337
Toxoplasma gondii aurora kinase 0.008 0.0077 0.5919
Brugia malayi A-kinase anchor protein 10, precursor 0.0768 0.1543 0.1503
Brugia malayi Protein kinase domain containing protein 0.0089 0.0098 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0246 0.043 0.0461
Echinococcus granulosus oxysterol binding protein 3 0.007 0.0057 0.0012
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0098 0.0337
Loa Loa (eye worm) TK/ALK protein kinase 0.0319 0.0587 0.0554
Brugia malayi MAX-1A 0.007 0.0057 0.001
Echinococcus multilocularis dynamin 1 0.007 0.0057 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Loa Loa (eye worm) hypothetical protein 0.016 0.0247 0.0213
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Schistosoma mansoni axis inhibition protein axin 0.0768 0.1543 0.1543
Schistosoma mansoni fibrocystin l 0.016 0.0247 0.0247
Trichomonas vaginalis AGC family protein kinase 0.008 0.0077 0.02
Echinococcus multilocularis regulator of G protein signaling 3 0.0768 0.1543 0.1799
Loa Loa (eye worm) hypothetical protein 0.0768 0.1543 0.1514
Schistosoma mansoni hypothetical protein 0.007 0.0057 0.0057
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1912 0.398 0.4729
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Brugia malayi PXA domain containing protein 0.0768 0.1543 0.1503
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Echinococcus multilocularis plexin a4 0.1019 0.2077 0.2441
Brugia malayi hypothetical protein 0.0365 0.0684 0.064
Entamoeba histolytica ARF GTPase activating protein, putative 0.007 0.0057 0.0067
Echinococcus granulosus tyrosine protein kinase Lyn 0.0085 0.0088 0.0049
Brugia malayi serine/threonine-protein kinase 6 0.008 0.0077 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Echinococcus multilocularis myotubularin protein 13 0.007 0.0057 0.0012
Schistosoma mansoni nephrin 0.0246 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0365 0.0684 0.0684
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0066 0.0047 0.0047
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Brugia malayi Cytohesin 3 0.007 0.0057 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0768 0.1543 0.1543
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4738 1 1
Loa Loa (eye worm) Plekhf2 protein 0.007 0.0057 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0768 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0082 0.0081 0.0041
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.007 0.0057 0.0012
Leishmania major protein kinase, putative 0.008 0.0077 0.5919
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.007 0.0057 0.001
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0089 0.0098 1
Echinococcus granulosus G protein coupled receptor kinase 1 0.2863 0.6007 0.7166
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Onchocerca volvulus 0.007 0.0057 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Schistosoma mansoni guanyl-nucleotide exchange factor 0.007 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.007 0.0057 0.0067
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0089 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Echinococcus granulosus regulator of G protein signaling 7 0.0768 0.1543 0.1799
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Echinococcus multilocularis Pleckstrin y 0.007 0.0057 0.0012
Brugia malayi Oxysterol binding protein 0.007 0.0057 0.001
Loa Loa (eye worm) hypothetical protein 0.0768 0.1543 0.1514
Onchocerca volvulus 0.0461 0.089 0.499
Loa Loa (eye worm) hypothetical protein 0.0365 0.0684 0.0651
Schistosoma mansoni hypothetical protein 0.0494 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.023 0.0398 0.0364
Echinococcus granulosus Pleckstrin domain containing protein family B 0.007 0.0057 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Loa Loa (eye worm) uncoordinated protein 104 0.007 0.0057 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.1543 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) PH domain-containing protein 0.007 0.0057 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica protein kinase , putative 0.008 0.0077 0.02
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Echinococcus granulosus pleckstrin y domain containing family A 0.007 0.0057 0.0012
Echinococcus granulosus Pleckstrin y 0.007 0.0057 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.007 0.0057 0.0012
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.007 0.0057 0.0012
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.007 0.0057 0.1986
Echinococcus multilocularis oxysterol binding protein 3 0.007 0.0057 0.0012
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Onchocerca volvulus Putative zinc finger protein 0.007 0.0057 0.0059
Trichomonas vaginalis alpha chimerin, putative 0.007 0.0057 0.0067
Entamoeba histolytica protein kinase, putative 0.008 0.0077 0.02
Brugia malayi Immunoglobulin I-set domain containing protein 0.0082 0.0081 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Onchocerca volvulus 0.007 0.0057 0.0059
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Echinococcus multilocularis Immunoglobulin 0.0225 0.0387 0.0409
Schistosoma mansoni serine/threonine-protein kinase 0.0089 0.0098 0.0098
Toxoplasma gondii Oxysterol-binding protein 0.007 0.0057 0.1986
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Echinococcus granulosus serine/threonine protein kinase 0.0089 0.0098 0.0061
Onchocerca volvulus 0.0365 0.0684 0.3768
Schistosoma mansoni protein tyrosine kinase 0.0066 0.0047 0.0047
Plasmodium falciparum oxysterol-binding protein, putative 0.007 0.0057 0.1986
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Brugia malayi plexin A 0.1019 0.2077 0.2039
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0089 0.0098 1
Echinococcus granulosus DCC interacting protein 13 beta 0.007 0.0057 0.0012
Trichomonas vaginalis AGC family protein kinase 0.008 0.0077 0.02
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0768 0.1543 0.1799
Echinococcus multilocularis Pleckstrin y 0.007 0.0057 0.0012
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0071 0.0058 0.0013
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) TK/ABL protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0098 0.0337
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0247 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0057 0.1986
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Onchocerca volvulus 0.007 0.0057 0.0059
Echinococcus granulosus aurora kinase A 0.008 0.0077 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0047 0.0047
Echinococcus granulosus Immunoglobulin 0.0225 0.0387 0.0409
Echinococcus multilocularis Rho GTPase activating protein 24 0.007 0.0057 0.0012
Onchocerca volvulus outspread protein homolog 0.007 0.0057 0.0059
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0066 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.3631 0.7643 0.7643
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0057 0.1986
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.007 0.0057 0.0067
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.007 0.0057 0.0012
Loa Loa (eye worm) TK/ROR protein kinase 0.0082 0.0081 0.0046
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0247 0.1338
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0047 0.0047
Schistosoma mansoni rho gtpase activating protein 0.007 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Schistosoma mansoni zinc finger protein 0.007 0.0057 0.0057
Loa Loa (eye worm) RGC/RGC protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) PXA domain-containing protein 0.0768 0.1543 0.1514
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Leishmania major protein kinase, putative 0.0085 0.0088 0.8014
Loa Loa (eye worm) hypothetical protein 0.0225 0.0387 0.0353
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Trichomonas vaginalis protein transport protein sec7, putative 0.007 0.0057 0.0067
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0768 0.1543 0.1799
Schistosoma mansoni goodpasture antigen-binding protein 0.007 0.0057 0.0057
Brugia malayi GTP-ase activating protein for Arf containing protein 0.007 0.0057 0.001
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0247 0.1338
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Schistosoma mansoni protein kinase 0.0085 0.0088 0.0088
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.0088 0.027
Loa Loa (eye worm) RGC/RGC protein kinase 0.0066 0.0047 0.0012
Echinococcus multilocularis beta 1 syntrophin 0.007 0.0057 0.0012
Brugia malayi hypothetical protein 0.0768 0.1543 0.1503
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0066 0.0047 0.0047
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0089 0.0098 0.0337
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.016 0.0247 0.0213
Trypanosoma brucei rac serine-threonine kinase, putative 0.0089 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0768 0.1543 0.1514
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Plasmodium vivax PH domain containing protein 0.007 0.0057 0.1986
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0225 0.0387 0.0387
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0768 0.1543 1
Schistosoma mansoni dynamin 0.007 0.0057 0.0057
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1682 0.1966
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0085 0.0088 0.8014
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Plasmodium vivax serine/threonine protein kinase 6, putative 0.008 0.0077 0.5919
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Schistosoma mansoni vav2 0.007 0.0057 0.0057
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.007 0.0057 0.1986
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0066 0.0047 0.0012
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0098 0.0337
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.007 0.0057 0.0012
Brugia malayi Dynamin 0.007 0.0057 0.001
Schistosoma mansoni rhogef and pleckstrin domain protein 0.007 0.0057 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica hypothetical protein 0.016 0.0247 0.1338
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.007 0.0057 0.0059
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Brugia malayi TBC domain containing protein 0.007 0.0057 0.001
Schistosoma mansoni protein kinase 0.0085 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0262 0.0464 0.0431
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Brugia malayi Sema domain containing protein 0.0365 0.0684 0.064
Brugia malayi PXA domain containing protein 0.0768 0.1543 0.1503
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0066 0.0047 0.0047
Brugia malayi Fibronectin type III domain containing protein 0.023 0.0398 0.0352
Echinococcus granulosus neuroglian 0.0241 0.0421 0.0449
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Brugia malayi Regulator of G protein signaling domain containing protein 0.0768 0.1543 0.1503
Schistosoma mansoni regulator of G protein signaling 0.0768 0.1543 0.1543
Schistosoma mansoni protein kinase 0.0085 0.0088 0.0088
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.007 0.0057 0.0057
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0768 0.1543 0.1514
Brugia malayi Regulator of G protein signaling domain containing protein 0.0768 0.1543 0.1503
Trichomonas vaginalis kinesin light chain, putative 0.007 0.0057 0.0067
Brugia malayi Syntrophin-1 0.007 0.0057 0.001
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0089 0.0098 1
Loa Loa (eye worm) AUR protein kinase 0.008 0.0077 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0077 0.0077
Schistosoma mansoni dynamin 0.007 0.0057 0.0057
Trichomonas vaginalis AGC family protein kinase 0.008 0.0077 0.02
Loa Loa (eye worm) RGS-3 protein 0.0768 0.1543 0.1514
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.007 0.0057 0.0022
Loa Loa (eye worm) sema domain-containing protein 0.0365 0.0684 0.0651
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Brugia malayi GTP-ase activating protein for Arf containing protein 0.007 0.0057 0.001
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0066 0.0047 0.0012
Echinococcus multilocularis oxysterol binding protein 1 0.007 0.0057 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Loa Loa (eye worm) variant SH3 domain-containing protein 0.007 0.0057 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Loa Loa (eye worm) RhoGEF domain-containing protein 0.007 0.0057 0.0022
Brugia malayi regulator of G-protein signaling egl-10 0.0768 0.1543 0.1503
Echinococcus granulosus exocyst complex component 2 0.016 0.0247 0.0241
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Entamoeba histolytica hypothetical protein 0.016 0.0247 0.1338
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Brugia malayi serine/threonine protein kinase 6 0.008 0.0077 0.003
Echinococcus granulosus beta 1 syntrophin 0.007 0.0057 0.0012
Loa Loa (eye worm) TK/FAK protein kinase 0.0066 0.0047 0.0012
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.007 0.0057 0.1986
Echinococcus multilocularis Ras associated and pleckstrin y 0.007 0.0057 0.0012
Brugia malayi Dynamin 0.007 0.0057 0.001
Loa Loa (eye worm) hypothetical protein 0.023 0.0398 0.0364
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0066 0.0047 0.0012
Echinococcus multilocularis hypothetical protein 0.0365 0.0684 0.0765
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Echinococcus multilocularis cytohesin 1 0.007 0.0057 0.0012
Entamoeba histolytica p21-activated kinase 0.0089 0.0098 0.0337
Loa Loa (eye worm) protein kinase domain-containing protein 0.0066 0.0047 0.0012
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0085 0.0088 0.0049
Echinococcus granulosus twitchin 0.026 0.0461 0.0498
Trichomonas vaginalis centaurin alpha, putative 0.007 0.0057 0.0067
Schistosoma mansoni serine/threonine RGC 0.0066 0.0047 0.0047
Echinococcus multilocularis oxysterol binding protein 9 0.007 0.0057 0.0012
Loa Loa (eye worm) TK/Met protein kinase 0.0066 0.0047 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0247 0.1338
Entamoeba histolytica cell surface protease gp63, putative 0.016 0.0247 0.1338
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Brugia malayi Cadps2 protein 0.007 0.0057 0.001
Echinococcus multilocularis Regulator of G protein signaling 20 0.0768 0.1543 0.1799
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.008 0.0077 0.02
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Echinococcus multilocularis rac serine:threonine kinase 0.0089 0.0098 0.0061
Trypanosoma cruzi Protein kinase B 0.0089 0.0098 1
Brugia malayi Plekhf2 protein 0.007 0.0057 0.001
Echinococcus multilocularis Oxysterol binding protein 11 0.007 0.0057 0.0012
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.008 0.0077 0.02
Brugia malayi Sema domain containing protein 0.0365 0.0684 0.064
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.0057 0.0067
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0089 0.0098 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0047 0.0047
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.007 0.0057 0.0059
Trichomonas vaginalis centaurin/arf, putative 0.007 0.0057 0.0067
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.008 0.0077 0.02
Echinococcus granulosus defective proboscis extension response 0.0225 0.0387 0.0409
Echinococcus granulosus activin receptor type 0.0085 0.0088 0.0049
Loa Loa (eye worm) TK/EPH protein kinase 0.0066 0.0047 0.0012
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.007 0.0057 0.1986
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Onchocerca volvulus Tyrosine kinase homolog 0.0543 0.1064 0.602
Echinococcus granulosus GRB2 associated binding protein 3 0.007 0.0057 0.0012
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.007 0.0057 0.0012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0768 0.1543 0.1543
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Leishmania major protein kinase, putative 0.0089 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Echinococcus granulosus Rho GTPase activating protein 24 0.007 0.0057 0.0012
Schistosoma mansoni vesicular amine transporter 0.0228 0.0393 0.0393
Loa Loa (eye worm) AGC/AKT protein kinase 0.0089 0.0098 0.0063
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Echinococcus multilocularis neuroglian 0.0241 0.0421 0.0449
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0089 0.0098 1
Entamoeba histolytica hypothetical protein 0.016 0.0247 0.1338
Entamoeba histolytica hypothetical protein 0.0768 0.1543 1
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0089 0.0098 1
Schistosoma mansoni tyrosine protein kinase 0.0066 0.0047 0.0047
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0098 0.0337
Entamoeba histolytica PH domain containing protein 0.007 0.0057 0.0067
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0066 0.0047 0.0047
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0225 0.0387 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Plasmodium falciparum protein kinase, putative 0.0085 0.0088 0.8014
Echinococcus multilocularis Immunoglobulin 0.0225 0.0387 0.0409
Trichomonas vaginalis centaurin beta, putative 0.007 0.0057 0.0067
Loa Loa (eye worm) sema domain-containing protein 0.0365 0.0684 0.0651
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.007 0.0057 0.0022
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.007 0.0057 0.0012
Schistosoma mansoni tyrosine kinase 0.0102 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0365 0.0684 0.0651
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0057 0.0067
Plasmodium vivax hypothetical protein, conserved 0.007 0.0057 0.1986
Schistosoma mansoni oxysterol-binding protein 1 0.007 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0022
Loa Loa (eye worm) syntrophin-1 0.007 0.0057 0.0022
Schistosoma mansoni hypothetical protein 0.007 0.0057 0.0057
Brugia malayi Plexin repeat family protein 0.0859 0.1737 0.1698
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0012
Schistosoma mansoni hypothetical protein 0.0066 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Trypanosoma brucei protein kinase, putative 0.0089 0.0098 1
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0057 0.0067
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0089 0.0098 1
Toxoplasma gondii hypothetical protein 0.007 0.0057 0.1986
Loa Loa (eye worm) TK/RYK protein kinase 0.0066 0.0047 0.0012
Brugia malayi hypothetical protein 0.007 0.0057 0.001
Entamoeba histolytica hypothetical protein 0.016 0.0247 0.1338
Echinococcus granulosus oxysterol binding protein 9 0.007 0.0057 0.0012
Plasmodium falciparum PH domain-containing protein, putative 0.007 0.0057 0.1986
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Echinococcus multilocularis DCC interacting protein 13 beta 0.007 0.0057 0.0012
Toxoplasma gondii phosphatidylinositol transfer protein 0.007 0.0057 0.1986
Brugia malayi DNA-binding protein LAG-1 0.016 0.0247 0.0201
Schistosoma mansoni plexin 0.0859 0.1737 0.1737
Echinococcus granulosus semaphorin 5B 0.0365 0.0684 0.0765
Loa Loa (eye worm) TK/DDR protein kinase 0.0066 0.0047 0.0012
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0089 0.0098 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.007 0.0057 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0089 0.0098 1
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0098 0.0337
Entamoeba histolytica protein kinase domain containing protein 0.0225 0.0387 0.2274
Brugia malayi Pleckstrin Homology Domain 0.007 0.0057 0.001
Echinococcus granulosus axis inhibition protein axin 0.0768 0.1543 0.1799
Loa Loa (eye worm) TK/CSK protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.0225 0.0387 0.0353
Brugia malayi serine/threonine kinase 12 0.008 0.0077 0.003
Entamoeba histolytica hypothetical protein 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.0365 0.0684 0.0651
Loa Loa (eye worm) RGC/RGC protein kinase 0.0066 0.0047 0.0012
Echinococcus multilocularis roundabout 2 0.0266 0.0475 0.0514
Brugia malayi regulator of G-protein signaling rgs-7 0.0768 0.1543 0.1503
Echinococcus multilocularis regulator of G protein signaling 3 0.0768 0.1543 0.1799
Entamoeba histolytica hypothetical protein 0.0089 0.0098 0.0337
Loa Loa (eye worm) oxysterol binding protein 0.007 0.0057 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.1543 1
Brugia malayi Probable exocyst complex component Sec5 0.016 0.0247 0.0201
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.007 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.0225 0.0387 0.0353
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.007 0.0057 0.0012
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0057 0.1986
Plasmodium falciparum calcium-dependent protein kinase 7 0.0089 0.0098 1
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0089 0.0098 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0066 0.0047 0.0012
Schistosoma mansoni protein kinase 0.008 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Entamoeba histolytica hypothetical protein 0.0768 0.1543 1
Trypanosoma cruzi hypothetical protein 0.007 0.0057 0.1986
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0066 0.0047 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0047 0.0012
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0247 0.1338
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0077 0.02
Echinococcus granulosus pdz domain containing protein 0.007 0.0057 0.0012
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.007 0.0057 0.0067
Onchocerca volvulus 0.007 0.0057 0.0059
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3969 0.8364 0.8356
Brugia malayi probable spectrin beta chain 0.007 0.0057 0.001
Trypanosoma cruzi NIMA-related kinase, putative 0.0089 0.0098 1
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.007 0.0057 0.1986
Schistosoma mansoni hypothetical protein 0.0365 0.0684 0.0684
Entamoeba histolytica PH domain containing protein 0.007 0.0057 0.0067
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0768 0.1543 0.1543
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.007 0.0057 0.0012
Echinococcus granulosus cytohesin 1 0.007 0.0057 0.0012
Echinococcus multilocularis beta adrenergic receptor kinase 0.3631 0.7643 0.9134
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0057 0.0067
Brugia malayi IPT/TIG domain containing protein 0.016 0.0247 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0057 0.0067
Schistosoma mansoni protein kinase 0.0066 0.0047 0.0047
Schistosoma mansoni growth factor receptor-bound protein 0.007 0.0057 0.0057
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.007 0.0057 0.0057
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.007 0.0057 0.0012
Brugia malayi PH domain containing protein 0.007 0.0057 0.001
Loa Loa (eye worm) rho-GTPase-activating 0.007 0.0057 0.0022
Brugia malayi Variant SH3 domain containing protein 0.007 0.0057 0.001
Echinococcus multilocularis semaphorin 5B 0.0365 0.0684 0.0765
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0098 0.0337
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.007 0.0057 0.0012
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0089 0.0098 1
Onchocerca volvulus 0.007 0.0057 0.0059
Loa Loa (eye worm) hypothetical protein 0.0494 0.096 0.0928
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Schistosoma mansoni hypothetical protein 0.007 0.0057 0.0057
Echinococcus granulosus Oxysterol binding protein 11 0.007 0.0057 0.0012
Echinococcus granulosus calcium dependent secretion activator 1 0.007 0.0057 0.0012
Echinococcus granulosus semaphorin 1A 0.0365 0.0684 0.0765
Loa Loa (eye worm) TK protein kinase 0.0066 0.0047 0.0012
Toxoplasma gondii AtPH1 family protein 0.007 0.0057 0.1986
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0057 0.0067
Brugia malayi Variant SH3 domain containing protein 0.007 0.0057 0.001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.0057 0.0067
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3969 0.8364 1
Entamoeba histolytica protein kinase, putative 0.0089 0.0098 0.0337
Loa Loa (eye worm) hypothetical protein 0.0768 0.1543 0.1514
Schistosoma mansoni tyrosine kinase 0.0066 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0082 0.0081 0.0041
Brugia malayi hypothetical protein 0.0768 0.1543 0.1503
Echinococcus multilocularis regulator of G protein signaling 7 0.0768 0.1543 0.1799
Loa Loa (eye worm) AUR protein kinase 0.008 0.0077 0.0042
Echinococcus multilocularis regulator of G protein signaling 0.0768 0.1543 0.1799
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0085 0.0088 0.8014
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.008 0.0077 0.0036
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0089 0.0098 1

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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