TDR Targets

Basic information

Technical information

TDR Targets ID: 1414892
Name: N-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-3 ,5-difluorobenzamide
MW: 323.295 | Formula: C15H15F2N3O3
H donors: 2 H acceptors: 3 LogP: 2.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cc(F)cc(c1)C(=O)NN1C(=O)NC2(C1=O)CCCCC2
InChi: 1S/C15H15F2N3O3/c16-10-6-9(7-11(17)8-10)12(21)19-20-13(22)15(18-14(20)23)4-2-1-3-5-15/h6-8H,1-5H2,(H,18,23)(H,19,21)
InChiKey: YUYIZTNUVRDGFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-3,5-difluoro-benzamide
N-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)-3,5-difluoro-benzamide
ZINC06993188
T5530826

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0687	0.1546	0.154
Echinococcus multilocularis	c src tyrosine kinase	0.005	0.0028	0.0026
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0687	0.1546	0.154
Echinococcus granulosus	regulator of G protein signaling 7	0.0687	0.1546	0.1842
Echinococcus multilocularis	exocyst complex component 2	0.0148	0.0263	0.0307
Trichomonas vaginalis	centaurin gamma, putative	0.0063	0.006	0.0387
Echinococcus multilocularis	FL cytokine receptor	0.005	0.0028	0.0026
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0028	0.0026
Schistosoma mansoni	zinc finger protein	0.0063	0.006	0.0045
Loa Loa (eye worm)	AUR protein kinase	0.0076	0.009	0.0084
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0028	0.0026
Echinococcus granulosus	transcription factor collier	0.0148	0.0263	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0263	0.0257
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.008	0.01	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Brugia malayi	hypothetical protein	0.0687	0.1546	0.154
Loa Loa (eye worm)	sema domain-containing protein	0.0338	0.0716	0.071
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trichomonas vaginalis	protein tyrosine kinase, putative	0.005	0.0028	0.0182
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	protein kinase	0.0067	0.0069	0.0053
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.0069	0.5609
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Brugia malayi	Syntrophin-1	0.0063	0.006	0.0053
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0063	0.006	0.0209
Brugia malayi	hypothetical protein	0.0338	0.0716	0.071
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.008	0.01	1
Entamoeba histolytica	hypothetical protein	0.0687	0.1546	1
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0063	0.006	0.4391
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0028	0.0026
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0063	0.006	0.0064
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.005	0.0028	0.0022
Brugia malayi	Raf kinase	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0063	0.006	0.0064
Schistosoma mansoni	protein kinase	0.0067	0.0069	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Giardia lamblia	Aurora kinase	0.0076	0.009	1
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0063	0.006	0.0064
Echinococcus granulosus	integrin linked protein kinase	0.005	0.0028	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Entamoeba histolytica	hypothetical protein, conserved	0.0063	0.006	0.0209
Echinococcus multilocularis	Immunoglobulin	0.0083	0.0107	0.012
Loa Loa (eye worm)	PH domain-containing protein	0.0063	0.006	0.0053
Brugia malayi	MAX-1A	0.0063	0.006	0.0053
Toxoplasma gondii	protein kinase domain-containing protein	0.008	0.01	1
Toxoplasma gondii	AtPH1 family protein	0.0063	0.006	0.4391
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0063	0.006	0.0053
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0687	0.1546	0.154
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0063	0.006	0.0064
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0083	0.0107	0.012
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0107	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Echinococcus granulosus	calcium dependent secretion activator 1	0.0063	0.006	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Brugia malayi	serine/threonine-protein kinase 6	0.0076	0.009	0.0084
Echinococcus multilocularis	oxysterol binding protein 3	0.0063	0.006	0.0064
Loa Loa (eye worm)	TK/EPH protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0063	0.006	0.0064
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Leishmania major	folate/biopterin transporter, putative	0.008	0.01	1
Loa Loa (eye worm)	oxysterol binding protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	uncoordinated protein 104	0.0063	0.006	0.0053
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	dynamin 1	0.0063	0.006	0.0064
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine protein kinase shark	0.005	0.0028	0.0026
Echinococcus granulosus	tyrosine protein kinase Src64B	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	epidermal growth factor receptor	0.005	0.0028	0.0026
Onchocerca volvulus	outspread protein homolog	0.0063	0.006	0.0178
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0063	0.006	0.0387
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Entamoeba histolytica	hypothetical protein	0.0063	0.006	0.0209
Echinococcus granulosus	myotubularin protein 13	0.0063	0.006	0.0064
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	tyrosine protein kinase HCK	0.005	0.0028	0.0026
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0338	0.0716	0.071
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0338	0.0716	0.071
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	Oxysterol-binding protein	0.0063	0.006	0.0053
Brugia malayi	Receptor family ligand binding region containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.0028	0.0013
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.0263	0.17
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0107	0.0101
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0067	0.0069	0.0074
Echinococcus granulosus	pleckstrin y domain containing family A	0.0063	0.006	0.0064
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.005	0.0028	0.0022
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.0028	0.0022
Echinococcus granulosus	Immunoglobulin	0.0083	0.0107	0.012
Brugia malayi	Immunoglobulin I-set domain containing protein	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0687	0.1546	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0055	0.004	0.004
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3247	0.7644	0.9139
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Echinococcus granulosus	protein kinase	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0063	0.006	0.0064
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0063	0.006	0.0064
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0063	0.006	0.0209
Echinococcus multilocularis	Pleckstrin y	0.0063	0.006	0.0064
Trichomonas vaginalis	centaurin/arf, putative	0.0063	0.006	0.0387
Loa Loa (eye worm)	TK/Met protein kinase	0.005	0.0028	0.0022
Entamoeba histolytica	hypothetical protein	0.008	0.01	0.0476
Echinococcus granulosus	epidermal growth factor receptor	0.005	0.0028	0.0026
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0063	0.006	0.0064
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus granulosus	dynamin 1	0.0063	0.006	0.0064
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.005	0.0028	0.0182
Trichomonas vaginalis	TK family protein kinase	0.005	0.0028	0.0182
Schistosoma mansoni	vesicular amine transporter	0.0085	0.0113	0.0098
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.005	0.0028	0.0026
Echinococcus multilocularis	aurora kinase A	0.0076	0.009	0.01
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	Tyrosine-protein kinase abl-1	0.005	0.0028	0.0022
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.008	0.01	1
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0028	0.0182
Brugia malayi	ephrin receptor 1 precursor	0.005	0.0028	0.0022
Brugia malayi	Plexin repeat family protein	0.0797	0.1807	0.1802
Entamoeba histolytica	tyrosin kinase, putative	0.0198	0.0381	0.2327
Echinococcus multilocularis	integrin linked protein kinase	0.005	0.0028	0.0026
Echinococcus multilocularis	rac serine:threonine kinase	0.008	0.01	0.0112
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0133	0.0225	0.0219
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.005	0.0028	0.0026
Brugia malayi	Plekhf2 protein	0.0063	0.006	0.0053
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Trypanosoma brucei	aurora B kinase	0.0076	0.009	0.8557
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0063	0.006	0.0053
Echinococcus granulosus	defective proboscis extension response	0.0083	0.0107	0.012
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Schistosoma mansoni	serine/threonine-protein kinase	0.008	0.01	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus granulosus	tyrosine kinase	0.005	0.0028	0.0026
Brugia malayi	hypothetical protein	0.0687	0.1546	0.154
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Schistosoma mansoni	protein tyrosine kinase	0.005	0.0028	0.0013
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0063	0.006	0.4391
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Schistosoma mansoni	regulator of G protein signaling	0.0687	0.1546	0.1533
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.008	0.01	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0107	0.0101
Echinococcus granulosus	pdz domain containing protein	0.0063	0.006	0.0064
Trypanosoma cruzi	NIMA-related kinase, putative	0.008	0.01	1
Loa Loa (eye worm)	AUR protein kinase	0.0076	0.009	0.0084
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus granulosus	receptor type guanylyl cyclase	0.005	0.0028	0.0026
Echinococcus granulosus	raf serine:threonine protein kinase	0.005	0.0028	0.0026
Echinococcus multilocularis	regulator of G protein signaling 7	0.0687	0.1546	0.1842
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0013
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	PXA domain-containing protein	0.0687	0.1546	0.154
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Brugia malayi	SH2 domain containing protein	0.005	0.0028	0.0022
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.0263	0.17
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0063	0.006	0.0064
Echinococcus granulosus	roundabout 2	0.0088	0.0119	0.0135
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0063	0.006	0.0209
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0687	0.1546	0.1842
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.006	0.0053
Echinococcus granulosus	expressed protein	0.0687	0.1546	0.1842
Schistosoma mansoni	nephrin	0.0088	0.0119	0.0104
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Toxoplasma gondii	aurora kinase	0.0076	0.009	0.8557
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0026
Schistosoma mansoni	dynamin	0.0063	0.006	0.0045
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.0028	0.0013
Echinococcus multilocularis	tyrosine protein kinase	0.005	0.0028	0.0026
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0076	0.009	0.8557
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0687	0.1546	0.154
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.005	0.0028	0.0026
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0063	0.006	0.0178
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0076	0.009	0.0407
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Brugia malayi	Fibronectin type III domain containing protein	0.0088	0.0119	0.0113
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Toxoplasma gondii	hypothetical protein	0.0063	0.006	0.4391
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0687	0.1546	0.154
Trypanosoma cruzi	PH domain containing protein, putative	0.0063	0.006	0.4391
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0067	0.0069	0.5609
Loa Loa (eye worm)	TK/EGFR protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0026
Trichomonas vaginalis	STE family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.005	0.0028	0.0026
Echinococcus multilocularis	ephrin type A receptor 4 A	0.005	0.0028	0.0026
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.008	0.01	0.0649
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Echinococcus granulosus	tyrosine protein kinase HCK	0.005	0.0028	0.0026
Schistosoma mansoni	ephrin receptor	0.0055	0.004	0.0025
Plasmodium falciparum	calcium-dependent protein kinase 7	0.008	0.01	1
Loa Loa (eye worm)	sema domain-containing protein	0.0338	0.0716	0.071
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Entamoeba histolytica	PH domain containing protein	0.0063	0.006	0.0209
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.005	0.0028	0.0022
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3549	0.8364	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Echinococcus granulosus	kinase suppressor of Ras 1	0.005	0.0028	0.0026
Echinococcus multilocularis	kinase suppressor of Ras 1	0.005	0.0028	0.0026
Echinococcus multilocularis	raf serine:threonine protein kinase	0.005	0.0028	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0067	0.0069	0.0074
Echinococcus granulosus	DCC interacting protein 13 beta	0.0063	0.006	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0687	0.1546	0.1842
Loa Loa (eye worm)	RGS-3 protein	0.0687	0.1546	0.154
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.005	0.0028	0.0026
Echinococcus granulosus	activated cdc42 kinase 1	0.005	0.0028	0.0026
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	tyrosine kinase	0.005	0.0028	0.0026
Entamoeba histolytica	cell surface protease gp63, putative	0.0148	0.0263	0.1547
Onchocerca volvulus		0.0338	0.0716	0.3865
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.0263	0.17
Echinococcus multilocularis	protein kinase	0.005	0.0028	0.0026
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0028	0.0013
Leishmania major	hypothetical protein, conserved	0.0063	0.006	0.4391
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0063	0.006	0.4391
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Schistosoma mansoni	hypothetical protein	0.0063	0.006	0.0045
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.005	0.0028	0.0026
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.0263	0.17
Echinococcus granulosus	oxysterol binding protein 9	0.0063	0.006	0.0064
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.005	0.0028	0.0026
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0022
Echinococcus granulosus	axis inhibition protein axin	0.0687	0.1546	0.1842
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0083	0.0107	0.012
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	Furin-like cysteine rich region family protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	syntrophin	0.0063	0.006	0.0045
Schistosoma mansoni	goodpasture antigen-binding protein	0.0063	0.006	0.0045
Schistosoma mansoni	goodpasture antigen-binding protein	0.0063	0.006	0.0045
Toxoplasma gondii	hypothetical protein	0.0063	0.006	0.4391
Loa Loa (eye worm)	hypothetical protein	0.0338	0.0716	0.071
Schistosoma mansoni	dynamin	0.0063	0.006	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0338	0.0716	0.071
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.005	0.0028	0.0013
Trichomonas vaginalis	protein transport protein sec7, putative	0.0063	0.006	0.0387
Echinococcus granulosus	tyrosine kinase	0.005	0.0028	0.0026
Onchocerca volvulus	Putative zinc finger protein	0.0063	0.006	0.0178
Entamoeba histolytica	hypothetical protein	0.008	0.01	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.008	0.01	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0687	0.1546	0.154
Echinococcus granulosus	axis inhibition protein axin	0.0687	0.1546	0.1842
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0076	0.009	0.0407
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0076	0.009	0.8557
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	axis inhibition protein axin	0.0687	0.1546	0.1533
Trichomonas vaginalis	conserved hypothetical protein	0.0687	0.1546	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3549	0.8364	1
Brugia malayi	Protein kinase domain containing protein	0.008	0.01	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.009	0.0582
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus granulosus	Pleckstrin y	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma brucei	PH domain containing protein, putative	0.0063	0.006	0.4391
Brugia malayi	hypothetical protein	0.0088	0.0119	0.0113
Brugia malayi	hypothetical protein	0.0063	0.006	0.0053
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3247	0.7644	0.9139
Echinococcus granulosus	Regulator of G protein signaling 20	0.0687	0.1546	0.1842
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	p21-activated kinase	0.008	0.01	0.0476
Brugia malayi	hypothetical protein	0.0338	0.0716	0.071
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0028	0.0013
Trichomonas vaginalis	hypothetical protein	0.0063	0.006	0.0387
Brugia malayi	Oxysterol binding protein	0.0063	0.006	0.0053
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0063	0.006	0.0064
Schistosoma mansoni	hypothetical protein	0.0063	0.006	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Brugia malayi	TBC domain containing protein	0.0063	0.006	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Leishmania major	serine/threonine-protein kinase a, putative	0.008	0.01	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0083	0.0107	0.0092
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	axis inhibition protein axin	0.0687	0.1546	0.1533
Echinococcus multilocularis	transcription factor collier	0.0148	0.0263	0.0307
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0063	0.006	0.0387
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0055	0.004	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0022
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Echinococcus granulosus	tyrosine protein kinase Blk	0.005	0.0028	0.0026
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0063	0.006	0.4391
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Entamoeba histolytica	protein kinase, putative	0.0076	0.009	0.0407
Loa Loa (eye worm)	TK/ALK protein kinase	0.0292	0.0604	0.0598
Entamoeba histolytica	hypothetical protein	0.0148	0.0263	0.1547
Echinococcus granulosus	tyrosine protein kinase shark	0.005	0.0028	0.0026
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Trypanosoma cruzi	aurora B kinase, putative	0.0076	0.009	0.8557
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.008	0.01	1
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus granulosus	GRB2 associated binding protein 3	0.0063	0.006	0.0064
Brugia malayi	protein-tyrosine kinase	0.005	0.0028	0.0022
Schistosoma mansoni	hypothetical protein	0.0063	0.006	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine kinase	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0417	0.0411
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Trypanosoma brucei	protein kinase, putative	0.0067	0.0069	0.5609
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.005	0.0028	0.0026
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	cytohesin 1	0.0063	0.006	0.0064
Brugia malayi	Sema domain containing protein	0.0338	0.0716	0.071
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0026
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	axis inhibition protein axin	0.0687	0.1546	0.1842
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.005	0.0028	0.0026
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.0028	0.0013
Echinococcus granulosus	aurora kinase A	0.0076	0.009	0.01
Schistosoma mansoni	growth factor receptor-bound protein	0.0063	0.006	0.0045
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Trichomonas vaginalis	centaurin/arf, putative	0.0063	0.006	0.0387
Trypanosoma cruzi	PH domain containing protein, putative	0.0063	0.006	0.4391
Echinococcus granulosus	beta 1 syntrophin	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Loa Loa (eye worm)	SRC-1	0.005	0.0028	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.008	0.01	1
Brugia malayi	probable spectrin beta chain	0.0063	0.006	0.0053
Schistosoma mansoni	centaurin alpha	0.0063	0.006	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	vav2	0.0063	0.006	0.0045
Echinococcus granulosus	tyrosine protein kinase Srms	0.005	0.0028	0.0026
Echinococcus granulosus	epidermal growth factor receptor	0.005	0.0028	0.0026
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.0028	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Schistosoma mansoni	regulator of G protein signaling	0.0687	0.1546	0.1533
Echinococcus granulosus	twitchin	0.01	0.0147	0.0169
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0063	0.006	0.0045
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.008	0.01	1
Loa Loa (eye worm)	hypothetical protein	0.0338	0.0716	0.071
Echinococcus granulosus	ephrin type A receptor 4 A	0.005	0.0028	0.0026
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.01	0.0476
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.008	0.01	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.005	0.0028	0.0026
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0063	0.006	0.0064
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.008	0.01	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	oxysterol binding protein 3	0.0063	0.006	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Onchocerca volvulus		0.0797	0.1807	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	pdz domain containing protein	0.0063	0.006	0.0064
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0063	0.006	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0063	0.006	0.4391
Schistosoma mansoni	hypothetical protein	0.0338	0.0716	0.0701
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.005	0.0028	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	natriuretic peptide receptor 1	0.005	0.0028	0.0026
Trichomonas vaginalis	kinesin light chain, putative	0.0063	0.006	0.0387
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	protein kinase	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Trypanosoma brucei	protein kinase, putative	0.008	0.01	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0063	0.006	0.0209
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Echinococcus multilocularis	beta 1 syntrophin	0.0063	0.006	0.0064
Onchocerca volvulus		0.0063	0.006	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0797	0.1807	0.1802
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0063	0.006	0.4391
Brugia malayi	Cytohesin 3	0.0063	0.006	0.0053
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Entamoeba histolytica	hypothetical protein	0.0687	0.1546	1
Echinococcus granulosus	tyrosine kinase	0.005	0.0028	0.0026
Echinococcus multilocularis	Oxysterol binding protein 11	0.0063	0.006	0.0064
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.3247	0.7644	0.7641
Schistosoma mansoni	protein kinase	0.0076	0.009	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1001	0.0995
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0687	0.1546	0.1533
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Entamoeba histolytica	hypothetical protein	0.0063	0.006	0.0209
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.0687	0.1546	1
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0063	0.006	0.0064
Entamoeba histolytica	PH domain containing protein	0.0063	0.006	0.0209
Entamoeba histolytica	hypothetical protein	0.0148	0.0263	0.1547
Echinococcus granulosus	fibroblast growth factor receptor 4	0.005	0.0028	0.0026
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0026
Schistosoma mansoni	hypothetical protein	0.0458	0.1001	0.0987
Echinococcus multilocularis	regulator of G protein signaling 7	0.0687	0.1546	0.1842
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Schistosoma mansoni	zinc finger protein	0.0063	0.006	0.0045
Echinococcus multilocularis	activated cdc42 kinase 1	0.005	0.0028	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0088	0.0119	0.0113
Echinococcus granulosus	semaphorin 1A	0.0338	0.0716	0.0849
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0063	0.006	0.0209
Entamoeba histolytica	hypothetical protein	0.0148	0.0263	0.1547
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0076	0.009	0.01
Echinococcus granulosus	activated cdc42 kinase 1	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Brugia malayi	Guanylyl cyclase protein 23	0.005	0.0028	0.0022
Echinococcus granulosus	serine/threonine protein kinase	0.008	0.01	0.0112
Echinococcus granulosus	neuroglian	0.0083	0.0107	0.012
Loa Loa (eye worm)	AGC/AKT protein kinase	0.008	0.01	0.0094
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.008	0.01	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	IPT/TIG domain containing protein	0.0148	0.0263	0.0257
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Echinococcus granulosus	protein tyrosine kinase	0.005	0.0028	0.0026
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Entamoeba histolytica	hypothetical protein	0.0063	0.006	0.0209
Brugia malayi	DNA-binding protein LAG-1	0.0148	0.0263	0.0257
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Toxoplasma gondii	Oxysterol-binding protein	0.0063	0.006	0.4391
Brugia malayi	Protein kinase domain containing protein	0.0292	0.0605	0.0599
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.009	0.0582
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Schistosoma mansoni	plexin	0.0458	0.1001	0.0987
Echinococcus granulosus	cytohesin 1	0.0063	0.006	0.0064
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0063	0.006	0.0064
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK/ACK protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trypanosoma cruzi	NIMA-related kinase, putative	0.008	0.01	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.0028	0.0022
Schistosoma mansoni	hypothetical protein	0.0063	0.006	0.0045
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.009	0.0582
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0687	0.1546	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3549	0.8364	0.8363
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	TK/DDR protein kinase	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Echinococcus multilocularis	transfer RNA-Thr	0.005	0.0028	0.0026
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.005	0.0028	0.0026
Echinococcus granulosus	G protein coupled receptor kinase 1	0.256	0.6008	0.7181
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0133	0.0225	0.0219
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0063	0.006	0.0045
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0063	0.006	0.4391
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0107	0.0101
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0687	0.1546	0.154
Echinococcus multilocularis	roundabout 2	0.0088	0.0119	0.0135
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	regulator of G protein signaling	0.0687	0.1546	0.1533
Trypanosoma cruzi	PH domain containing protein, putative	0.0063	0.006	0.4391
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0063	0.006	0.0387
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	Immunoglobulin	0.0083	0.0107	0.012
Trichomonas vaginalis	alpha chimerin, putative	0.0063	0.006	0.0387
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Echinococcus multilocularis	neuroglian	0.0083	0.0107	0.012
Entamoeba histolytica	hypothetical protein	0.0063	0.006	0.0209
Loa Loa (eye worm)	rho-GTPase-activating	0.0063	0.006	0.0053
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.005	0.0028	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	oxysterol binding protein 1	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	hypothetical protein	0.0148	0.0263	0.1547
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3549	0.8364	0.8363
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	oxysterol-binding protein 1	0.0063	0.006	0.0045
Loa Loa (eye worm)	TK/CSK protein kinase	0.005	0.0028	0.0022
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3549	0.8364	0.8363
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.008	0.01	1
Brugia malayi	Cadps2 protein	0.0063	0.006	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Brugia malayi	integrin-linked kinase	0.005	0.0028	0.0022
Schistosoma mansoni	oxysterol-binding protein 1	0.0063	0.006	0.0045
Echinococcus multilocularis	axis inhibition protein axin	0.0687	0.1546	0.1842
Echinococcus multilocularis	protein tyrosine kinase	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Onchocerca volvulus		0.0063	0.006	0.0178
Schistosoma mansoni	hypothetical protein	0.0148	0.0263	0.0248
Onchocerca volvulus		0.0063	0.006	0.0178
Echinococcus granulosus	regulator of G protein signaling 3	0.0687	0.1546	0.1842
Echinococcus multilocularis	tyrosine protein kinase Blk	0.005	0.0028	0.0026
Brugia malayi	Pleckstrin Homology Domain	0.0063	0.006	0.0053
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.0028	0.0022
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.005	0.0028	0.0026
Onchocerca volvulus		0.0063	0.006	0.0178
Echinococcus granulosus	regulator of G protein signaling 7	0.0687	0.1546	0.1842
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0063	0.006	0.4391
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Echinococcus granulosus	semaphorin 5B	0.0338	0.0716	0.0849
Entamoeba histolytica	protein kinase domain containing protein	0.0067	0.0069	0.0267
Plasmodium falciparum	protein kinase, putative	0.0067	0.0069	0.5609
Schistosoma mansoni	plexin	0.0797	0.1807	0.1795
Schistosoma mansoni	fibrocystin l	0.0148	0.0263	0.0248
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0063	0.006	0.0064
Schistosoma mansoni	regulator of G protein signaling	0.0687	0.1546	0.1533
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.008	0.01	0.0649
Echinococcus multilocularis	regulator of G protein signaling	0.0687	0.1546	0.1842
Echinococcus multilocularis	tyrosine protein kinase Srms	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0026
Onchocerca volvulus		0.0063	0.006	0.0178
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0063	0.006	0.0053
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.006	0.0053
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.005	0.0028	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Echinococcus granulosus	tyrosine protein kinase ABL1	0.005	0.0028	0.0026
Plasmodium falciparum	PH domain-containing protein, putative	0.0063	0.006	0.4391
Echinococcus granulosus	Rho GTPase activating protein 24	0.0063	0.006	0.0064
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.01	0.0476
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Brugia malayi	plexin A	0.0945	0.216	0.2155
Trichomonas vaginalis	protein kinase atn1, putative	0.005	0.0028	0.0182
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0687	0.1546	0.1533
Trichomonas vaginalis	conserved hypothetical protein	0.0687	0.1546	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.0182
Leishmania major	protein kinase, putative	0.0067	0.0069	0.5609
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.005	0.0028	0.0026
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.0069	0.5609
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Echinococcus granulosus	Pleckstrin y	0.0063	0.006	0.0064
Echinococcus multilocularis	tyrosine protein kinase pr2	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0119	0.0113
Echinococcus multilocularis	protein KINase family member (kin 25)	0.005	0.0028	0.0026
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0063	0.006	0.0209
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	regulator of G protein signaling 3	0.0687	0.1546	0.1842
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.009	0.0075
Echinococcus multilocularis	actin binding protein anillin	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.005	0.0028	0.0026
Brugia malayi	regulator of G-protein signaling egl-10	0.0687	0.1546	0.154
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.005	0.0028	0.0026
Echinococcus multilocularis	tyrosine protein kinase Abl	0.005	0.0028	0.0026
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Brugia malayi	Uncoordinated protein 104	0.0063	0.006	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Brugia malayi	PH domain containing protein	0.0063	0.006	0.0053
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0063	0.006	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus multilocularis	oxysterol binding protein 9	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma cruzi	Protein kinase B	0.008	0.01	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0119	0.0113
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0028	0.0026
Echinococcus granulosus	tyrosine protein kinase Src42A	0.005	0.0028	0.0026
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	hypothetical protein	0.0338	0.0716	0.0849
Loa Loa (eye worm)	syntrophin-1	0.0063	0.006	0.0053
Schistosoma mansoni	myotubularin-related protein	0.0063	0.006	0.0045
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.01	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0107	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0076	0.009	0.01
Entamoeba histolytica	protein kinase , putative	0.0076	0.009	0.0407
Schistosoma mansoni	serine/threonine protein kinase	0.4236	1	1
Echinococcus multilocularis	Pleckstrin y	0.0063	0.006	0.0064
Brugia malayi	hypothetical protein	0.005	0.0028	0.0022
Brugia malayi	PXA domain containing protein	0.0687	0.1546	0.154
Schistosoma mansoni	hypothetical protein	0.0063	0.006	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Schistosoma mansoni	z-protein (S1r protein)	0.0687	0.1546	0.1533
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.005	0.0028	0.0026
Echinococcus multilocularis	heat shock protein 70	0.005	0.0028	0.0026
Brugia malayi	hypothetical protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.256	0.6008	0.7181
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.008	0.01	1
Schistosoma mansoni	serine/threonine-protein kinase	0.008	0.01	0.0085
Onchocerca volvulus		0.0063	0.006	0.0178
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0063	0.006	0.4391
Schistosoma mansoni	protein kinase	0.0067	0.0069	0.0053
Brugia malayi	C-terminal src kinase protein 1	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0063	0.006	0.0053
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0063	0.006	0.0053
Loa Loa (eye worm)	AUR protein kinase	0.0076	0.009	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0263	0.0257
Echinococcus multilocularis	plexin a4	0.0945	0.216	0.2577
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0076	0.009	0.0407
Echinococcus multilocularis	regulator of G protein signaling 3	0.0687	0.1546	0.1842
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0063	0.006	0.0064
Loa Loa (eye worm)	plexin A	0.0945	0.216	0.2155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.005	0.0028	0.0022
Brugia malayi	Sema domain containing protein	0.0338	0.0716	0.071
Loa Loa (eye worm)	TK/ABL protein kinase	0.005	0.0028	0.0022
Brugia malayi	Probable exocyst complex component Sec5	0.0148	0.0263	0.0257
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0063	0.006	0.0064
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0063	0.006	0.0053
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.005	0.0028	0.0026
Entamoeba histolytica	hypothetical protein	0.0063	0.006	0.0209
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0067	0.0069	0.0074
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	serine/threonine protein kinase	0.005	0.0028	0.0022
Entamoeba histolytica	PH domain containing protein	0.0063	0.006	0.0209
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trypanosoma cruzi	PH domain containing protein, putative	0.0063	0.006	0.4391
Loa Loa (eye worm)	TK/FAK protein kinase	0.005	0.0028	0.0022
Echinococcus granulosus	activin receptor type	0.0067	0.0069	0.0074
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Plasmodium vivax	hypothetical protein, conserved	0.0063	0.006	0.4391
Plasmodium falciparum	oxysterol-binding protein, putative	0.0063	0.006	0.4391
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.008	0.01	1
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0063	0.006	0.0387
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Leishmania major	protein kinase, putative	0.0076	0.009	0.8557
Brugia malayi	serine/threonine protein kinase 6	0.0076	0.009	0.0084
Echinococcus multilocularis	myotubularin protein 13	0.0063	0.006	0.0064
Echinococcus granulosus	tyrosine protein kinase	0.005	0.0028	0.0026
Onchocerca volvulus		0.0063	0.006	0.0178
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Schistosoma mansoni	hypothetical protein	0.0148	0.0263	0.0248
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0263	0.0257
Echinococcus multilocularis	semaphorin 5B	0.0338	0.0716	0.0849
Schistosoma mansoni	semaphorin 5-related	0.0338	0.0716	0.0701
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0063	0.006	0.0209
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Loa Loa (eye worm)	TK/RYK protein kinase	0.005	0.0028	0.0022
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0687	0.1546	0.154
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0687	0.1546	0.1842
Loa Loa (eye worm)	cytohesin 3	0.0063	0.006	0.0053
Echinococcus granulosus	Oxysterol binding protein 11	0.0063	0.006	0.0064
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0026
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.008	0.01	1
Trypanosoma cruzi	hypothetical protein	0.0063	0.006	0.4391
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	Pleckstrin y	0.0063	0.006	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0063	0.006	0.0387
Echinococcus granulosus	regulator of G protein signaling 3	0.0687	0.1546	0.1842
Loa Loa (eye worm)	TK/ROR protein kinase	0.005	0.0028	0.0022
Plasmodium vivax	PH domain containing protein	0.0063	0.006	0.4391
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	ephrin receptor	0.005	0.0028	0.0013
Brugia malayi	SRC-1	0.005	0.0028	0.0022
Echinococcus granulosus	tyrosine protein kinase pr2	0.005	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4236	1	1
Echinococcus granulosus	insulin receptor	0.005	0.0028	0.0026
Trichomonas vaginalis	protein transport protein sec7, putative	0.0063	0.006	0.0387
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Loa Loa (eye worm)	Plekhf2 protein	0.0063	0.006	0.0053
Brugia malayi	SH2 domain containing protein	0.005	0.0028	0.0022
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.005	0.0028	0.0026
Brugia malayi	regulator of G-protein signaling rgs-7	0.0687	0.1546	0.154
Brugia malayi	Dynamin	0.0063	0.006	0.0053
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0022
Brugia malayi	PXA domain containing protein	0.0687	0.1546	0.154
Onchocerca volvulus	Protein melted homolog	0.0063	0.006	0.0178
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Echinococcus multilocularis	epidermal growth factor receptor	0.005	0.0028	0.0026
Brugia malayi	bone morphogenetic protein type 1 receptor	0.005	0.0028	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.009	0.0582
Schistosoma mansoni	tyrosine protein kinase	0.005	0.0028	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0076	0.009	0.0407
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0063	0.006	0.0045
Echinococcus multilocularis	expressed protein	0.0687	0.1546	0.1842
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Trypanosoma brucei	rac serine-threonine kinase, putative	0.008	0.01	1
Schistosoma mansoni	hypothetical protein	0.005	0.0028	0.0013
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0063	0.006	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0119	0.0113
Trichomonas vaginalis	centaurin beta, putative	0.0063	0.006	0.0387
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0026
Brugia malayi	hypothetical protein	0.005	0.0028	0.0022
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.0263	0.17
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.005	0.0028	0.0182
Brugia malayi	Dynamin	0.0063	0.006	0.0053
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0022
Leishmania major	protein kinase, putative	0.008	0.01	1
Entamoeba histolytica	protein kinase, putative	0.008	0.01	0.0476
Brugia malayi	serine/threonine kinase 12	0.0076	0.009	0.0084
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.005	0.0028	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Leishmania major	hypothetical protein, conserved	0.0063	0.006	0.4391
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Leishmania major	protein kinase, putative	0.008	0.01	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0028	0.0026
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3247	0.7644	0.7643
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	protein kinase, putative	0.0076	0.009	0.0407
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.006	0.0387
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.005	0.0028	0.0026
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0687	0.1546	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0022
Echinococcus multilocularis	insulin receptor	0.005	0.0028	0.0026
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0063	0.006	0.4391
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.008	0.01	1
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0107	0.0101
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0063	0.006	0.0045
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0013
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0063	0.006	0.0178
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Echinococcus granulosus	oxysterol binding protein 1	0.0063	0.006	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0263	0.0257
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0687	0.1546	0.1533
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0687	0.1546	0.154
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0063	0.006	0.0209
Schistosoma mansoni	cell adhesion molecule	0.0088	0.0119	0.0104
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.01	0.0476
Echinococcus granulosus	natriuretic peptide receptor 1	0.005	0.0028	0.0026
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.01	0.0476
Brugia malayi	Tyrosine-protein kinase PR2	0.005	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0687	0.1546	0.154
Echinococcus granulosus	c src tyrosine kinase	0.005	0.0028	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Echinococcus granulosus	Pleckstrin y	0.0063	0.006	0.0064
Echinococcus granulosus	plexin a4	0.0945	0.216	0.2577
Schistosoma mansoni	serine/threonine RGC	0.005	0.0028	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.3247	0.7644	0.7641
Loa Loa (eye worm)	hypothetical protein	0.0338	0.0716	0.071
Loa Loa (eye worm)	protein kinase domain-containing protein	0.005	0.0028	0.0022
Schistosoma mansoni	hypothetical protein	0.0338	0.0716	0.0701
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0013
Schistosoma mansoni	regulator of G protein signaling	0.0687	0.1546	0.1533
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0083	0.0107	0.0092
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.0028	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0263	0.17
Trichomonas vaginalis	AGC family protein kinase	0.008	0.01	0.0649
Schistosoma mansoni	rho gtpase activating protein	0.0063	0.006	0.0045
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.0069	0.5609
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.0182
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.01	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0687	0.1546	1
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.008	0.01	1
Echinococcus multilocularis	activin receptor type	0.0067	0.0069	0.0074
Echinococcus granulosus	exocyst complex component 2	0.0148	0.0263	0.0307
Trichomonas vaginalis	centaurin alpha, putative	0.0063	0.006	0.0387
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.0381	0.2327
Entamoeba histolytica	hypothetical protein	0.0687	0.1546	1
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0063	0.006	0.0064

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1553104

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1414892