Detailed information for compound 1428215

Basic information

Technical information
  • TDR Targets ID: 1428215
  • Name: N-[1-(cyclohexylamino)-2-methyl-1-oxobutan-2- yl]-N-phenylpyridine-2-carboxamide
  • MW: 379.495 | Formula: C23H29N3O2
  • H donors: 1 H acceptors: 3 LogP: 4.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(N(C(=O)c1ccccn1)c1ccccc1)(C(=O)NC1CCCCC1)C
  • InChi: 1S/C23H29N3O2/c1-3-23(2,22(28)25-18-12-6-4-7-13-18)26(19-14-8-5-9-15-19)21(27)20-16-10-11-17-24-20/h5,8-11,14-18H,3-4,6-7,12-13H2,1-2H3,(H,25,28)
  • InChiKey: LKWGQLXEBZDIQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-(cyclohexylcarbamoyl)-1-methyl-propyl]-N-phenyl-pyridine-2-carboxamide
  • N-[1-[(cyclohexylamino)-oxomethyl]-1-methylpropyl]-N-phenyl-2-pyridinecarboxamide
  • N-[1-(cyclohexylcarbamoyl)-1-methyl-propyl]-N-phenyl-picolinamide
  • N-[1-(cyclohexylamino)-2-methyl-1-oxo-butan-2-yl]-N-phenyl-pyridine-2-carboxamide
  • ChemDiv3_007557
  • EU-0054754
  • IDI1_025467
  • MLS000519745
  • SMR000130163
  • STK149148

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0104 0.0185
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0062 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0141
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0055 0.0523
Brugia malayi jmjC domain containing protein 0.0041 0.007 0.0164
Echinococcus multilocularis beta tubulin 0.0898 0.3618 0.3613
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0311 0.0552
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0055 0.0048
Echinococcus multilocularis thymidylate synthase 0.0112 0.0362 0.0355
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0075 0.0209 0.0569
Brugia malayi Muscleblind-like protein 0.0301 0.1144 0.3142
Brugia malayi nuclear hormone receptor family member nhr-6 0.0062 0.0154 0.0398
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0054 0.0136
Brugia malayi Cytochrome P450 family protein 0.008 0.023 0.0607
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0185 0.1978
Mycobacterium ulcerans thymidylate synthase 0.0112 0.0362 0.3969
Brugia malayi Tubulin gamma chain 0.0557 0.2202 0.6076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0036 0.0091
Onchocerca volvulus 0.0137 0.0465 0.2295
Toxoplasma gondii isocitrate dehydrogenase 0.0112 0.0363 0.098
Brugia malayi beta-tubulin, identical 0.0898 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0141
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0054 0.0083
Trypanosoma brucei beta tubulin 0.0898 0.3618 1
Entamoeba histolytica hypothetical protein 0.0294 0.1115 0.3066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0364 0.4016
Brugia malayi Heterochromatin protein 1 0.0073 0.0199 0.0522
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.0363 0.099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0137 0.0465 0.1277
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0367 0.0653
Schistosoma mansoni tubulin subunit beta 0.0898 0.3618 0.6426
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0209 0.0549
Trichomonas vaginalis tubulin beta chain, putative 0.0683 0.2727 0.7535
Echinococcus granulosus chromobox protein 1 0.0073 0.0199 0.0342
Schistosoma mansoni alpha tubulin 0.0683 0.2727 0.4844
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.005 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0011
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0036 0.0052
Entamoeba histolytica tubulin alpha-1 chain 0.0683 0.2727 0.7533
Toxoplasma gondii endonuclease IV APN 0.008 0.0229 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.003 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0025 0.0057
Loa Loa (eye worm) Smad1 0.005 0.0104 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0137 0.0465 0.0458
Trichomonas vaginalis tubulin gamma chain, putative 0.0242 0.0899 0.2475
Trichomonas vaginalis tubulin beta chain, putative 0.0683 0.2727 0.7535
Trypanosoma brucei beta tubulin 0.0557 0.2202 0.6078
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0055 0.0129
Echinococcus multilocularis hypothetical protein 0.0683 0.2727 0.2722
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0102 0.1053
Brugia malayi chromobox protein homolog 3 0.0041 0.0067 0.0156
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0158 0.0551 0.1503
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0368 0.1424 0.3928
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.005 0.0113
Leishmania major hypothetical protein, conserved 0.0041 0.007 0.0181
Giardia lamblia Delta tubulin 0.0242 0.0899 0.2462
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0112 0.0363 0.098
Brugia malayi hypothetical protein 0.0062 0.0154 0.0398
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0102 0.0271
Plasmodium vivax tubulin alpha chain, putative 0.0683 0.2727 0.7533
Mycobacterium leprae cell division protein FtsZ 0.0242 0.0899 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0132 0.0443 0.1205
Onchocerca volvulus 0.0054 0.0123 0.0592
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0367 0.1004
Onchocerca volvulus 0.0038 0.0054 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.0129
Plasmodium vivax JmjC domain containing protein 0.0041 0.007 0.017
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0442 0.1727 0.4769
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0224 0.0826 0.1456
Loa Loa (eye worm) BEN-1 protein 0.0898 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0209 0.0569
Onchocerca volvulus 0.0038 0.0054 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0261 0.0451
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0055 0.0085
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0062 0.0154 0.0274
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Echinococcus multilocularis isocitrate dehydrogenase 0.0112 0.0363 0.0356
Trypanosoma brucei epsilon tubulin 0.0557 0.2202 0.6078
Brugia malayi phosphofructokinase 0.0113 0.0367 0.0989
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0242 0.0899 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0306 0.1163 0.321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0185 0.1978
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0229 0.251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0261 0.0254
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0364 0.3989
Echinococcus granulosus CREB binding protein 0.0076 0.0213 0.0366
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0112 0.0363 0.0356
Loa Loa (eye worm) tubulin gamma chain 0.0557 0.2202 0.6084
Schistosoma mansoni cpg binding protein 0.003 0.0022 0.004
Trichomonas vaginalis tubulin beta chain, putative 0.0315 0.1202 0.3314
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0923 0.2542
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0364 0.3989
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0168 0.0299
Brugia malayi beta-lactamase 0.0038 0.0054 0.0119
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.007 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0284 0.0504
Trypanosoma cruzi zeta tubulin, putative 0.0242 0.0899 0.2475
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.003 0.0059
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0011 0.0004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0055 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Trichomonas vaginalis tubulin gamma chain, putative 0.0898 0.3618 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0168 0.0457
Echinococcus granulosus thymidylate synthase 0.0112 0.0362 0.0631
Plasmodium falciparum tubulin epsilon chain, putative 0.0557 0.2202 0.6078
Echinococcus multilocularis geminin 0.1385 0.563 0.5627
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0062 0.0163
Leishmania major beta tubulin 0.0898 0.3618 1
Trypanosoma brucei alpha tubulin 0.0683 0.2727 0.7533
Schistosoma mansoni jumonji domain containing protein 0.0041 0.007 0.0124
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0027 0.0035
Brugia malayi alpha-tubulin 0.0683 0.2727 0.7531
Schistosoma mansoni hypothetical protein 0.0131 0.0442 0.0784
Brugia malayi MH2 domain containing protein 0.005 0.0104 0.0258
Schistosoma mansoni smad 0.005 0.0104 0.0185
Echinococcus granulosus Tubulin beta 2C chain 0.0898 0.3618 0.6421
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0025 0.004
Mycobacterium ulcerans cell division protein FtsZ 0.0242 0.0899 1
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0367 0.0994
Loa Loa (eye worm) hypothetical protein 0.0095 0.0291 0.0796
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0137 0.0465 0.0825
Brugia malayi beta-lactamase family protein 0.0038 0.0054 0.0119
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0367 0.0994
Trichomonas vaginalis tubulin gamma chain, putative 0.0557 0.2202 0.6082
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Leishmania major beta tubulin 0.0898 0.3618 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0054 0.0136
Schistosoma mansoni smad1 5 8 and 0.005 0.0104 0.0185
Leishmania major beta tubulin 0.0898 0.3618 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0025 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0212 0.0575
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0067 0.0311
Brugia malayi acetyltransferase, GNAT family protein 0.0443 0.1733 0.4776
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0416 0.4573
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.005 0.0124
Giardia lamblia Histone acetyltransferase GCN5 0.0119 0.0391 0.1054
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0054 0.0506
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0112 0.0364 0.098
Toxoplasma gondii beta-1 tubulin, putative 0.0898 0.3618 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0067 0.0172
Mycobacterium tuberculosis Conserved protein 0.0038 0.0054 0.0506
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0416 0.4597
Brugia malayi Pre-SET motif family protein 0.0218 0.0799 0.2185
Brugia malayi intermediate filament protein 0.0054 0.0123 0.0312
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0011 0.0022
Echinococcus multilocularis tubulin alpha chain 0.0683 0.2727 0.2722
Schistosoma mansoni dihydrofolate reductase 0.0046 0.0087 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0284 0.0492
Echinococcus granulosus Tubulin beta 2C chain 0.0898 0.3618 0.6421
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3348 0.5947
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0168 0.0442
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.005 0.0043
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0025 0.0184
Echinococcus multilocularis tubulin alpha chain 0.0683 0.2727 0.2722
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.0465 0.0458
Leishmania major beta tubulin 0.0898 0.3618 1
Leishmania major hypothetical protein, conserved 0.0076 0.0212 0.0575
Trichomonas vaginalis tubulin alpha chain, putative 0.0898 0.3618 1
Brugia malayi nuclear receptor NHR-88 0.0062 0.0154 0.0398
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0367 0.403
Chlamydia trachomatis dihydrofolate reductase 0.0046 0.0087 0.3689
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0137 0.0465 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.0465 0.1258
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.009 0.0083
Giardia lamblia Beta tubulin 0.0898 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0123 0.0333
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0367 0.1004
Trichomonas vaginalis tubulin beta chain, putative 0.0683 0.2727 0.7535
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0075 0.0209 0.0359
Echinococcus granulosus Tubulin beta 2C chain 0.0898 0.3618 0.6421
Echinococcus multilocularis tubulin subunit TubB 0.0683 0.2727 0.2722
Schistosoma mansoni thyroid hormone receptor 0.0268 0.1008 0.179
Echinococcus multilocularis CREB binding protein 0.0083 0.0243 0.0236
Loa Loa (eye worm) tubulin alpha 2 0.0442 0.1727 0.4769
Mycobacterium tuberculosis Cell division protein FtsZ 0.0242 0.0899 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0137 0.0465 0.0458
Schistosoma mansoni nuclear hormone receptor 0.0137 0.0465 0.0825
Giardia lamblia Alpha-tubulin 0.0683 0.2727 0.7531
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0048
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0367 0.0653
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0154 0.0262
Loa Loa (eye worm) hypothetical protein 0.0053 0.0119 0.0322
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0137 0.0465 0.0825
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0054 0.0506
Echinococcus multilocularis jumonji domain containing 1A 0.0041 0.007 0.0063
Leishmania major gamma-tubulin 0.0557 0.2202 0.6082
Brugia malayi Thioredoxin reductase 0.0049 0.0102 0.0254
Onchocerca volvulus 0.0112 0.0362 0.1784
Entamoeba histolytica acetyltransferase, GNAT family 0.0119 0.0391 0.1059
Echinococcus multilocularis ecdysone induced protein 78C 0.0137 0.0465 0.0458
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0055 0.0523
Giardia lamblia Epsilon tubulin 0.0242 0.0899 0.2462
Loa Loa (eye worm) hypothetical protein 0.0088 0.0261 0.0715
Loa Loa (eye worm) nuclear hormone receptor 0.0062 0.0154 0.0419
Brugia malayi Dihydrofolate reductase 0.0046 0.0087 0.0213
Echinococcus granulosus thyroid hormone receptor alpha 0.0062 0.0154 0.0262
Schistosoma mansoni phd/f-box containing protein 0.0041 0.007 0.0124
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.007 0.0186
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0054 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0025 0.0057
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0075 0.0209 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.0465 0.1258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0284 0.0277
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0137 0.0465 0.1277
Toxoplasma gondii beta-tubulin, putative 0.0898 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0229 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0054 0.0136
Schistosoma mansoni tubulin subunit alpha 0.0242 0.0899 0.1596
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0054 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0137 0.0465 0.1258
Echinococcus multilocularis Tubulin alpha 1 chain 0.0683 0.2727 0.2722
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0367 0.1004
Trypanosoma cruzi zeta tubulin, putative 0.0242 0.0899 0.2475
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0442 0.1727 0.4767
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0062 0.0158
Onchocerca volvulus Alhambra homolog 0.0033 0.0036 0.0156
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0141
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0137 0.0465 0.0825
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0168 0.0453
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0168 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0067 0.0172
Schistosoma mansoni single-minded 0.0099 0.0307 0.0545
Trichomonas vaginalis tubulin epsilon chain, putative 0.0683 0.2727 0.7535
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.005 0.0108
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0062 0.0154 0.0147
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0112 0.0362 0.0993
Trichomonas vaginalis tubulin alpha chain, putative 0.0315 0.1202 0.3314
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0315 0.1202 0.3314
Echinococcus multilocularis tubulin beta 1 chain 0.0898 0.3618 0.3613
Loa Loa (eye worm) tubulin beta chain 0.0242 0.0899 0.2478
Brugia malayi MH1 domain containing protein 0.0027 0.0012 0.0004
Schistosoma mansoni tubulin subunit alpha 0.0683 0.2727 0.4844
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0055 0.0145
Onchocerca volvulus 0.003 0.0022 0.0088
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0367 0.1004
Loa Loa (eye worm) DR-78 0.0062 0.0154 0.0419
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0137 0.0465 0.0814
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0066
Chlamydia trachomatis endonuclease IV 0.008 0.0229 1
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0048
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0062 0.0154 0.0262
Loa Loa (eye worm) hypothetical protein 0.0075 0.0209 0.0569
Loa Loa (eye worm) tubulin beta-1 chain 0.0898 0.3618 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0367 0.1008
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0158 0.0551 0.1503
Echinococcus granulosus jumonji domain containing 1A 0.0041 0.007 0.0112
Echinococcus multilocularis phd:f box containing protein 0.0041 0.007 0.0063
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0113
Brugia malayi MH1 domain containing protein 0.005 0.0104 0.0258
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.005 0.0108
Loa Loa (eye worm) acetyltransferase 0.0443 0.1733 0.4787
Loa Loa (eye worm) tubulin alpha 2 0.0442 0.1727 0.4769
Mycobacterium tuberculosis Conserved protein 0.0038 0.0054 0.0506
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0364 0.3989
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0055 0.0123
Brugia malayi steroid hormone receptor 0.0137 0.0465 0.1258
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0168 0.0442
Schistosoma mansoni chromobox protein 0.0073 0.0199 0.0353
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0036 0.0075
Schistosoma mansoni smad1 5 8 and 0.005 0.0104 0.0185
Brugia malayi Pax transcription factor protein 2 0.051 0.2008 0.5537
Toxoplasma gondii beta tubulin 0.0898 0.3618 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0315 0.1202 0.3314
Loa Loa (eye worm) hypothetical protein 0.0032 0.0031 0.0077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0102 0.0096
Onchocerca volvulus 0.0069 0.0183 0.089
Brugia malayi Cell division protein ftsZ 0.0242 0.0899 0.2462
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0025 0.0045
Plasmodium vivax tubulin gamma chain, putative 0.0557 0.2202 0.6078
Loa Loa (eye worm) tubulin alpha-3 chain 0.0368 0.1424 0.3931
Schistosoma mansoni tubulin subunit beta 0.0898 0.3618 0.6426
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0168 0.0453
Echinococcus multilocularis tubulin alpha 3 chain 0.0683 0.2727 0.2722
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0104 0.0097
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.005 0.0076
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0055 0.0523
Echinococcus granulosus Nuclear hormone receptor HR96 0.0062 0.0154 0.0262
Trypanosoma brucei zeta tubulin 0.0242 0.0899 0.2466
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0367 0.0994
Echinococcus multilocularis transcription factor eb 0.0112 0.0364 0.0357
Loa Loa (eye worm) p25-alpha family protein 0.0381 0.1477 0.4079
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0112 0.0363 0.099
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0102 0.0275
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0367 0.1004
Schistosoma mansoni RAR-like nuclear receptor 0.0137 0.0465 0.0825
Echinococcus granulosus geminin 0.1385 0.563 1
Schistosoma mansoni tubulin subunit epsilon 0.0557 0.2202 0.3912
Onchocerca volvulus 0.0038 0.0054 0.0245
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Loa Loa (eye worm) hypothetical protein 0.0098 0.0304 0.0833
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0112 0.0362 0.3969
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.003 0.0053
Giardia lamblia Beta tubulin 0.0898 0.3618 1
Echinococcus multilocularis Smad4 0.005 0.0104 0.0097
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3348 0.5942
Brugia malayi MH1 domain containing protein 0.0027 0.0012 0.0004
Echinococcus granulosus tubulin alpha chain 0.0683 0.2727 0.4838
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0137 0.0465 0.0458
Echinococcus granulosus tubulin beta 1 chain 0.0898 0.3618 0.6421
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0025 0.0912
Brugia malayi nuclear hormone receptor 0.0137 0.0465 0.1258
Brugia malayi jmjC domain containing protein 0.0041 0.007 0.0164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0137 0.0465 0.0825
Echinococcus granulosus lamin dm0 0.0054 0.0123 0.0207
Schistosoma mansoni nuclear receptor nhr-48 0.0062 0.0154 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0137 0.0465 0.1258
Loa Loa (eye worm) nuclear factor I 0.0027 0.0012 0.0025
Entamoeba histolytica tubulin gamma chain 0.0557 0.2202 0.6078
Leishmania major beta tubulin 0.0898 0.3618 1
Entamoeba histolytica tubulin alpha chain, putative 0.0683 0.2727 0.7533
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0062 0.0154 0.0147
Trichomonas vaginalis chromobox protein, putative 0.0044 0.008 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0154 0.0147
Echinococcus granulosus phd:f box containing protein 0.0041 0.007 0.0112
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.0119 0.0316
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0036 0.0075
Echinococcus multilocularis tubulin gamma 1 chain 0.0557 0.2202 0.2197
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.0465 0.0814
Echinococcus granulosus tubulin alpha chain 0.0683 0.2727 0.4838
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0036 0.0091
Echinococcus granulosus Smad4 0.005 0.0104 0.0172
Brugia malayi hypothetical protein 0.0294 0.1115 0.3062
Plasmodium vivax tubulin beta chain, putative 0.0898 0.3618 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0055 0.0129
Plasmodium falciparum glutathione reductase 0.0049 0.0102 0.026
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0229 0.0605
Trichomonas vaginalis tubulin, putative 0.0315 0.1202 0.3314
Brugia malayi jmjC domain containing protein 0.0041 0.007 0.0164
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Trichomonas vaginalis tubulin beta chain, putative 0.0898 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0067 0.0177
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0025 0.0057
Echinococcus multilocularis tubulin alpha chain 0.0683 0.2727 0.2722
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0201 0.0194
Onchocerca volvulus 0.0315 0.1202 0.5976
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0119 0.0316
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0284 0.0777
Mycobacterium tuberculosis Conserved protein 0.0038 0.0054 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0025 0.0057
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0025 0.0045
Loa Loa (eye worm) tubulin beta chain 0.0898 0.3618 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.005 0.0088
Echinococcus granulosus tubulin alpha 1C chain 0.0683 0.2727 0.4838
Echinococcus granulosus tubulin subunit beta 0.0898 0.3618 0.6421
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0141
Loa Loa (eye worm) tubulin alpha-2 chain 0.0683 0.2727 0.7537
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0027 0.0044
Brugia malayi Bromodomain containing protein 0.0046 0.0088 0.0215
Echinococcus multilocularis tubulin alpha 1C chain 0.0683 0.2727 0.2722
Brugia malayi nuclear receptor RXR 0.0075 0.0209 0.0549
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0367 0.0641
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.0891 0.9911
Brugia malayi thymidylate synthase 0.0112 0.0362 0.0974
Echinococcus granulosus tubulin beta 4A class IVa 0.0898 0.3618 0.6421
Schistosoma mansoni thyroid hormone receptor 0.0268 0.1008 0.179
Schistosoma mansoni phosphatidylserine receptor 0.0041 0.007 0.0124
Loa Loa (eye worm) hypothetical protein 0.0076 0.0212 0.0579
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Schistosoma mansoni hypothetical protein 0.0067 0.0176 0.0312
Brugia malayi Tubulin alpha-2 chain 0.0683 0.2727 0.7531
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Echinococcus multilocularis Tubulin beta 2C chain 0.0898 0.3618 0.3613
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0367 0.403
Echinococcus multilocularis FTZ F1 alpha 0.0137 0.0465 0.0458
Onchocerca volvulus 0.0032 0.0031 0.0129
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0201 0.0527
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0209 0.0549
Trichomonas vaginalis tubulin beta chain, putative 0.0683 0.2727 0.7535
Loa Loa (eye worm) tubulin alpha 2 0.0127 0.0423 0.1163
Brugia malayi nuclear receptor NHR-88 0.0137 0.0465 0.1258
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0132 0.0443 0.1214
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0132 0.0443 0.1205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.003 0.0053
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0062 0.0154 0.0274
Echinococcus granulosus beta tubulin 0.0898 0.3618 0.6421
Echinococcus granulosus peroxisome assembly protein 26 0.0683 0.2727 0.4838
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Echinococcus granulosus tumor protein p63 0.0681 0.2717 0.4819
Trypanosoma cruzi alpha tubulin, putative 0.0683 0.2727 0.7535
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0239 0.089 0.157
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0367 0.0994
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0186
Loa Loa (eye worm) hypothetical protein 0.0368 0.1424 0.3931
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0137 0.0465 0.0825
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0212 0.0564
Trypanosoma brucei epsilon tubulin 0.0557 0.2202 0.6078
Brugia malayi Steroid receptor seven-up type 2 0.0137 0.0465 0.1258
Echinococcus granulosus smad 0.005 0.0104 0.0172
Onchocerca volvulus 0.0062 0.0154 0.0747
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0229 0.2476
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0055 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0137 0.0465 0.1258
Loa Loa (eye worm) nuclear receptor NHR-67 0.0062 0.0154 0.0419
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0123 0.0333
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0062 0.0154 0.0419
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0137 0.0465 0.2295
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0104 0.0172
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0176 0.0457
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0025 0.0912
Echinococcus granulosus lysine specific demethylase 5A 0.0157 0.0549 0.0964
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0364 0.3989
Trichomonas vaginalis tubulin beta chain, putative 0.0683 0.2727 0.7535
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0284 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0137 0.0465 0.1258
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0022 0.0054
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0212 0.0564
Echinococcus granulosus FTZ F1 alpha 0.0137 0.0465 0.0814
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0022 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0284 0.0492
Onchocerca volvulus TPPP family protein homolog 0.0381 0.1477 0.735
Giardia lamblia Gamma tubulin 0.0557 0.2202 0.6076
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0054 0.0136
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0007 0.0011
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0416 0.4573
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0039 0.0057
Echinococcus multilocularis muscleblind protein 0.0301 0.1144 0.1138
Leishmania major beta tubulin 0.0898 0.3618 1
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0199 0.0538
Brugia malayi photoreceptor-specific nuclear receptor 0.0137 0.0465 0.1258
Brugia malayi MH1 domain containing protein 0.005 0.0104 0.0258
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.0363 0.099
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0182 0.0496
Echinococcus multilocularis Tubulin alpha 1 chain 0.0683 0.2727 0.2722
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0011 0.0006
Echinococcus multilocularis Tubulin beta 2C chain 0.0898 0.3618 0.3613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0137 0.0465 0.1258
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0062 0.0158
Loa Loa (eye worm) BEN-1 protein 0.0898 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0311 0.0852
Echinococcus granulosus tubulin alpha 1C chain 0.0683 0.2727 0.4838
Loa Loa (eye worm) hypothetical protein 0.0075 0.0209 0.0569
Brugia malayi 6-phosphofructokinase 0.0113 0.0367 0.0989
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.005 0.0076
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0104 0.0279
Plasmodium falciparum tubulin beta chain 0.0898 0.3618 1
Loa Loa (eye worm) tubulin alpha chain 0.0683 0.2727 0.7537
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0025 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.0137 0.0465 0.0825
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0043 0.0077 0.007
Brugia malayi hypothetical protein 0.0076 0.0212 0.0559
Echinococcus multilocularis lysine specific demethylase 6a 0.0041 0.007 0.0063
Trichomonas vaginalis esterase, putative 0.0038 0.0054 0.0136
Brugia malayi glutathione reductase 0.0049 0.0102 0.0254
Echinococcus granulosus lysine specific demethylase 6a 0.0041 0.007 0.0112
Echinococcus granulosus cpg binding protein 0.0032 0.0029 0.004
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0229 0.0611
Echinococcus multilocularis tubulin epsilon chain 0.0557 0.2202 0.2197
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0018 0.0036
Echinococcus multilocularis tubulin alpha chain 0.0683 0.2727 0.2722
Loa Loa (eye worm) hypothetical protein 0.005 0.0104 0.0279
Leishmania major beta tubulin 0.0898 0.3618 1
Brugia malayi MH2 domain containing protein 0.0728 0.2914 0.8048
Schistosoma mansoni intermediate filament proteins 0.0054 0.0123 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0137 0.0465 0.1277
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0112 0.0363 0.098
Brugia malayi PHD-finger family protein 0.0033 0.0036 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0185 0.1978
Loa Loa (eye worm) hypothetical protein 0.0442 0.1727 0.4769
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0918 0.2516
Trypanosoma cruzi tubulin delta chain 0.0242 0.0899 0.2475
Echinococcus multilocularis chromobox protein 1 0.0073 0.0199 0.0192
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.005 0.0043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0104 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0055 0.014
Trypanosoma brucei alpha tubulin 0.0683 0.2727 0.7533
Trichomonas vaginalis tubulin alpha chain, putative 0.0557 0.2202 0.6082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0166 0.0295
Echinococcus multilocularis tubulin alpha 1C chain 0.0683 0.2727 0.2722
Brugia malayi hypothetical protein 0.0075 0.0209 0.0549
Brugia malayi orphan nuclear receptor NR2E1 0.0062 0.0154 0.0398
Schistosoma mansoni tubulin subunit beta 0.0898 0.3618 0.6426
Echinococcus multilocularis tubulin alpha 3 chain 0.0683 0.2727 0.2722
Plasmodium falciparum alpha tubulin 1 0.0683 0.2727 0.7533
Plasmodium vivax tubulin epsilon chain, putative 0.0557 0.2202 0.6078
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0112 0.0362 0.0643
Schistosoma mansoni CREB-binding protein 2 0.0116 0.038 0.0676
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0291 0.0776
Trichomonas vaginalis tubulin gamma chain, putative 0.0557 0.2202 0.6082
Loa Loa (eye worm) hypothetical protein 0.0112 0.0362 0.0993
Brugia malayi hypothetical protein 0.0062 0.0154 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.0465 0.1258
Schistosoma mansoni retinoic acid receptor RXR 0.0239 0.089 0.158
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0141
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0367 0.1008
Trichomonas vaginalis tubulin, putative 0.0242 0.0899 0.2475
Trypanosoma brucei beta tubulin 0.0898 0.3618 1
Echinococcus granulosus transcription factor eb 0.0112 0.0364 0.0635
Trypanosoma brucei alpha tubulin, putative 0.0315 0.1202 0.3306
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.007 0.0186
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.0363 0.0356
Trypanosoma brucei tubulin gamma chain 0.0557 0.2202 0.6078
Schistosoma mansoni nuclear receptor 0.0062 0.0154 0.0274
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0054 0.0506
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0041 0.007 0.017
Echinococcus granulosus tubulin alpha chain 0.0683 0.2727 0.4838
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.0119 0.1239
Echinococcus granulosus single minded 2 0.0073 0.0201 0.0345
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0123 0.0312
Echinococcus multilocularis lamin 0.0054 0.0123 0.0117
Entamoeba histolytica hypothetical protein 0.0294 0.1115 0.3066
Schistosoma mansoni lamin 0.0054 0.0123 0.0219
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0075 0.0209 0.0371
Entamoeba histolytica hypothetical protein 0.0294 0.1115 0.3066
Echinococcus multilocularis JmjC domain containing protein 4 0.0041 0.007 0.0063
Schistosoma mansoni tubulin subunit beta 0.0242 0.0899 0.1596
Onchocerca volvulus 0.0147 0.0507 0.2506
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0367 0.0361
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0112 0.0363 0.0632
Loa Loa (eye worm) hypothetical protein 0.0331 0.127 0.3504
Echinococcus multilocularis tumor protein p63 0.0681 0.2717 0.2712
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0898 0.3618 0.3613
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0041 0.007 0.017
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0212 0.0564
Schistosoma mansoni tubulin subunit alpha 0.0683 0.2727 0.4844
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0079 0.0141
Mycobacterium ulcerans hypothetical protein 0.0038 0.0054 0.0506
Loa Loa (eye worm) pax transcription factor protein 2 0.051 0.2008 0.5547
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Trypanosoma brucei beta tubulin 0.0898 0.3618 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0055 0.0086
Entamoeba histolytica tubulin family protein 0.0898 0.3618 1
Trichomonas vaginalis conserved hypothetical protein 0.0242 0.0899 0.2475
Echinococcus multilocularis Tubulin beta 2C chain 0.0898 0.3618 0.3613
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0154 0.0274
Echinococcus granulosus tubulin alpha 0.0557 0.2202 0.3904
Trichomonas vaginalis tubulin epsilon chain, putative 0.0898 0.3618 1
Leishmania major beta tubulin 0.0898 0.3618 1
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0104 0.0172
Echinococcus multilocularis tubulin alpha 0.0557 0.2202 0.2197
Trypanosoma brucei beta tubulin 0.0898 0.3618 1
Brugia malayi ecdysteroid receptor 0.0137 0.0465 0.1258
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.1911 0.1905
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0112 0.0363 0.3975
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0054 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0284 0.0757
Echinococcus granulosus neuropeptide s receptor 0.0486 0.1911 0.3385
Echinococcus multilocularis tubulin subunit beta 0.0898 0.3618 0.3613
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0229 0.0611
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0025 0.0045
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0367 0.4057
Trypanosoma cruzi epsilon tubulin, putative 0.0557 0.2202 0.6082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.007 0.0181
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0055 0.014
Schistosoma mansoni hypothetical protein 0.1385 0.563 1
Echinococcus granulosus alpha tubulin 0.0683 0.2727 0.4838
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0011 0.0017
Toxoplasma gondii thioredoxin reductase 0.0049 0.0102 0.026
Brugia malayi Nuclear hormone receptor E75 0.0062 0.0154 0.0398
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0102 0.017
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.023 0.0627
Trypanosoma brucei alpha tubulin 0.0683 0.2727 0.7533
Toxoplasma gondii ABC1 family protein 0.0038 0.0054 0.0125
Brugia malayi bZIP transcription factor family protein 0.0088 0.0261 0.0693
Echinococcus multilocularis cpg binding protein 0.0032 0.0029 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0018 0.0036
Schistosoma mansoni aryl hydrocarbon receptor 0.0099 0.0309 0.055
Brugia malayi PAS domain containing protein 0.0099 0.0307 0.0822
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0102 0.026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.0465 0.0814
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3348 0.3344
Leishmania major zeta tubulin, putative 0.0242 0.0899 0.2475
Treponema pallidum cell division protein FtsZ 0.0242 0.0899 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0054 0.0136
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0039 0.0032
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0011 0.0006
Echinococcus multilocularis lamin dm0 0.0054 0.0123 0.0117
Brugia malayi beta-lactamase family protein 0.0038 0.0054 0.0119
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0011 0.0017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.005 0.0124
Brugia malayi Cytochrome P450 family protein 0.0039 0.0062 0.0141
Leishmania major beta tubulin 0.0898 0.3618 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0284 0.0504
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0048
Echinococcus granulosus tubulin subunit TubB 0.0683 0.2727 0.4838
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.0363 0.098
Plasmodium vivax glutathione reductase, putative 0.0049 0.0102 0.026
Onchocerca volvulus Protein ultraspiracle homolog 0.0137 0.0465 0.2295
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.019 0.0503
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0242 0.0899 0.2466
Echinococcus multilocularis peroxisome assembly protein 26 0.0683 0.2727 0.2722
Brugia malayi jmjC domain containing protein 0.0041 0.007 0.0164
Toxoplasma gondii alpha-tubulin I, putative 0.0683 0.2727 0.7533
Echinococcus granulosus histone acetyltransferase KAT2B 0.0429 0.1674 0.2965
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0364 0.3989
Brugia malayi Tubulin alpha-2 chain 0.0683 0.2727 0.7531
Echinococcus granulosus Nuclear hormone receptor HR96 0.0062 0.0154 0.0262
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0137 0.0465 0.0814
Echinococcus multilocularis nuclear receptor nhr 48 0.0062 0.0154 0.0147
Brugia malayi Tubulin beta chain 0.0242 0.0899 0.2462
Trypanosoma cruzi epsilon tubulin, putative 0.0557 0.2202 0.6082
Entamoeba histolytica tubulin family protein 0.0898 0.3618 1
Brugia malayi hypothetical protein 0.0069 0.0183 0.0477
Trypanosoma cruzi tubulin gamma chain 0.0557 0.2202 0.6082
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0291 0.0516
Brugia malayi nuclear receptor RXR 0.0062 0.0154 0.0398
Brugia malayi jmjC domain containing protein 0.0224 0.0826 0.226
Plasmodium falciparum tubulin gamma chain 0.0557 0.2202 0.6078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0137 0.0465 0.1277
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0062 0.0154 0.0398
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.0465 0.1258
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0242 0.0899 0.2475
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0041 0.007 0.0124
Brugia malayi jmjC domain containing protein 0.0157 0.0549 0.1492
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0291 0.0504
Echinococcus granulosus chromobox protein 1 0.0073 0.0199 0.0342
Brugia malayi hypothetical protein 0.0147 0.0507 0.1375
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.007
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0009 0.0045
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0011 0.0017
Schistosoma mansoni chromobox protein 0.0073 0.0199 0.0353
Leishmania major beta tubulin 0.0898 0.3618 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0799 0.2202
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0062 0.0154 0.0747
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0137 0.0465 0.0825
Echinococcus granulosus histone acetyltransferase KAT2B 0.0132 0.0443 0.0776
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0048
Trypanosoma cruzi tubulin delta chain 0.0242 0.0899 0.2475
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.007 0.0186
Echinococcus granulosus lamin 0.0054 0.0123 0.0207
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0304 0.0813
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0158 0.0551 0.1503
Mycobacterium ulcerans endonuclease IV 0.008 0.0229 0.2476
Leishmania major beta tubulin 0.0898 0.3618 1
Leishmania major hypothetical protein, conserved 0.0038 0.0054 0.0136
Brugia malayi hypothetical protein 0.0331 0.127 0.349
Trichomonas vaginalis tubulin epsilon chain, putative 0.0898 0.3618 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0443 0.1733 0.3079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0104 0.0279
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0168 0.0161
Toxoplasma gondii alpha tubulin TUBA1 0.0683 0.2727 0.7533
Onchocerca volvulus Bile acid receptor homolog 0.0137 0.0465 0.2295
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0025 0.0057
Trypanosoma brucei tubulin delta chain 0.0242 0.0899 0.2466
Loa Loa (eye worm) transcription factor SMAD2 0.0728 0.2914 0.8053
Echinococcus granulosus Tubulin alpha 1 chain 0.0683 0.2727 0.4838
Echinococcus granulosus tubulin epsilon chain 0.0557 0.2202 0.3904
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0443 0.1733 0.1728
Schistosoma mansoni Smad4 0.005 0.0104 0.0185
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0062 0.0154 0.0147
Brugia malayi Tubulin alpha chain 0.0242 0.0899 0.2462
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0055 0.014
Brugia malayi Tubulin beta-1 chain 0.0898 0.3618 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0055 0.0129
Toxoplasma gondii isocitrate dehydrogenase 0.0112 0.0363 0.098
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0116 0.038 0.0676
Trichomonas vaginalis tubulin epsilon chain, putative 0.0242 0.0899 0.2475
Leishmania major beta tubulin 0.0898 0.3618 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.003 0.0023
Echinococcus granulosus JmjC domain containing protein 4 0.0041 0.007 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0212 0.0575
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.0465 0.0458
Brugia malayi Pre-SET motif family protein 0.0032 0.003 0.0053
Brugia malayi nuclear hormone receptor 0.0062 0.0154 0.0398
Brugia malayi hypoxia-induced factor 1 0.0306 0.1163 0.3195
Loa Loa (eye worm) thymidylate synthase 0.0112 0.0362 0.0993
Brugia malayi tailless protein 0.0062 0.0154 0.0398
Schistosoma mansoni tubulin subunit beta 0.0898 0.3618 0.6426
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0011 0.0006
Echinococcus granulosus tubulin alpha chain 0.0683 0.2727 0.4838
Leishmania major epsilon tubulin, putative 0.0557 0.2202 0.6082
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0025 0.0057
Trichomonas vaginalis tubulin beta chain, putative 0.0683 0.2727 0.7535
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0137 0.0465 0.1258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0124
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0158 0.0551 0.1503
Echinococcus granulosus muscleblind protein 0.0301 0.1144 0.2023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0007 0.0000068355
Loa Loa (eye worm) tubulin alpha chain 0.0683 0.2727 0.7537
Mycobacterium ulcerans beta-lactamase 0.0038 0.0054 0.0506
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.1911 0.1905
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0027 0.0066
Echinococcus granulosus tubulin delta chain 0.0242 0.0899 0.1586
Loa Loa (eye worm) CBP-B 0.0084 0.0247 0.0675
Onchocerca volvulus 0.0248 0.0923 0.4584
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.005 0.0043
Brugia malayi nuclear hormone receptor family member odr-7 0.0062 0.0154 0.0398
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.0363 0.0356
Schistosoma mansoni alpha tubulin 0.0683 0.2727 0.4844
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0137 0.0465 0.1258
Trypanosoma brucei epsilon tubulin 0.0557 0.2202 0.6078
Echinococcus granulosus Tubulin alpha 1 chain 0.0683 0.2727 0.4838
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.005 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0294 0.1115 0.1971
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0054 0.0506
Trichomonas vaginalis bromodomain-containing protein, putative 0.0132 0.0443 0.1214
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0185 0.0499
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.0465 0.1258
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0918 0.2532
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0367 0.1008
Brugia malayi Smad1 0.005 0.0104 0.0258
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0046 0.0087 0.0885
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Echinococcus multilocularis smad 0.005 0.0104 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0212 0.0564
Loa Loa (eye worm) hypothetical protein 0.0075 0.0209 0.0569
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0112 0.0362 0.3997
Onchocerca volvulus 0.051 0.2008 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0027 0.002
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0367 0.403
Brugia malayi ecdysone receptor 0.0062 0.0154 0.0398
Schistosoma mansoni hypothetical protein 0.1385 0.563 1
Loa Loa (eye worm) glutathione reductase 0.0049 0.0102 0.0275
Schistosoma mansoni nuclear receptor 0.0062 0.0154 0.0274
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0442 0.0773
Leishmania major beta tubulin 0.0898 0.3618 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0043 0.0077 0.0125
Mycobacterium ulcerans lipase LipD 0.0038 0.0054 0.0506
Leishmania major cytochrome p450-like protein 0.0039 0.0062 0.0158
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.005 0.0124
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0557 0.2202 0.6078
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0242 0.0899 0.2466
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0025 0.0045
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0062 0.0154 0.0747
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0212 0.0564
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.1911 0.3385
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0294 0.1115 0.1109
Brugia malayi hypothetical protein 0.0053 0.0119 0.03
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0137 0.0465 0.0814
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0367 0.1004
Echinococcus multilocularis tubulin alpha chain 0.0683 0.2727 0.2722
Brugia malayi Tubulin alpha chain 0.0683 0.2727 0.7531
Schistosoma mansoni coup transcription factor 0.0137 0.0465 0.0825
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Brugia malayi p25-alpha family protein 0.0381 0.1477 0.4066
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0062 0.0163
Leishmania major beta tubulin 0.0898 0.3618 1
Brugia malayi MH2 domain containing protein 0.005 0.0104 0.0258
Echinococcus granulosus tubulin alpha chain 0.0683 0.2727 0.4838
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Brugia malayi CXXC zinc finger family protein 0.003 0.0022 0.0032
Loa Loa (eye worm) beta-tubulin 0.0898 0.3618 1
Trichomonas vaginalis tubulin, putative 0.0315 0.1202 0.3314
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0158 0.0551 0.1512
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0683 0.2727 0.7535
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0137 0.0465 0.0458
Plasmodium vivax SET domain protein, putative 0.0032 0.003 0.0059
Trichomonas vaginalis tubulin alpha chain, putative 0.0315 0.1202 0.3314
Brugia malayi isocitrate dehydrogenase 0.0112 0.0363 0.0975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0284 0.0504
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0062 0.0163
Schistosoma mansoni jumonji/arid domain-containing protein 0.0157 0.0549 0.0975
Echinococcus granulosus tubulin alpha 3 chain 0.0683 0.2727 0.4838
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0137 0.0465 0.1277
Echinococcus multilocularis beta tubulin 0.0898 0.3618 0.3613
Loa Loa (eye worm) steroid hormone receptor 0.0137 0.0465 0.1277
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.005 0.0088
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0442 0.0435
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0158 0.0551 0.1512
Echinococcus multilocularis Tubulin beta 2C chain 0.0898 0.3618 0.3613
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0124
Brugia malayi TAZ zinc finger family protein 0.0116 0.038 0.1025
Echinococcus granulosus jun protein 0.0088 0.0261 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0186
Trypanosoma brucei zeta tubulin, putative 0.0242 0.0899 0.2466
Leishmania major beta tubulin 0.0898 0.3618 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0224 0.0826 0.082
Schistosoma mansoni tubulin subunit gamma 0.0557 0.2202 0.3912
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0019 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0054 0.0119
Echinococcus multilocularis peregrin 0.0046 0.0088 0.0081
Echinococcus granulosus Tubulin alpha 1 chain 0.0683 0.2727 0.4838
Plasmodium falciparum flap endonuclease 1 0.0027 0.0011 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0304 0.0833
Echinococcus multilocularis thyroid hormone receptor alpha 0.0268 0.1008 0.1001
Schistosoma mansoni alpha tubulin 0.0683 0.2727 0.4844
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0132 0.0443 0.1205
Echinococcus multilocularis musashi 0.0054 0.0123 0.0117
Trichomonas vaginalis tubulin epsilon chain, putative 0.0683 0.2727 0.7535
Giardia lamblia Beta tubulin 0.0898 0.3618 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0054 0.0549
Trichomonas vaginalis tubulin, putative 0.0898 0.3618 1
Plasmodium falciparum tubulin delta chain, putative 0.0242 0.0899 0.2466
Loa Loa (eye worm) isocitrate dehydrogenase 0.0112 0.0363 0.0995
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0062 0.0597
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0009 0.0181
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0112 0.0363 0.098
Loa Loa (eye worm) hypothetical protein 0.0301 0.1144 0.3157
Echinococcus multilocularis dihydrofolate reductase 0.0046 0.0087 0.0081
Echinococcus granulosus flap endonuclease 1 0.0027 0.0011 0.0007
Schistosoma mansoni tubulin subunit beta 0.0898 0.3618 0.6426
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0025 0.0045
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0036 0.0075
Loa Loa (eye worm) tubulin beta-2A chain 0.0898 0.3618 1
Onchocerca volvulus 0.0074 0.0203 0.0991
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0054 0.0141
Loa Loa (eye worm) hypothetical protein 0.0147 0.0507 0.1394
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0157 0.0549 0.1511
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0036 0.0029
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0291 0.0284
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0054 0.0506
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0027 0.0035
Loa Loa (eye worm) beta-lactamase 0.0038 0.0054 0.0141
Echinococcus granulosus CREB binding protein 0.0116 0.038 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0137 0.0465 0.1258
Plasmodium vivax tubulin alpha chain, putative 0.0683 0.2727 0.7533
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0185 0.0178
Giardia lamblia Alpha-tubulin 0.0683 0.2727 0.7531
Brugia malayi tubulin alpha chain - mouse 0.0683 0.2727 0.7531
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0075 0.0209 0.0371
Schistosoma mansoni cpg binding protein 0.0032 0.0029 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.0363 0.0356
Loa Loa (eye worm) MH2 domain-containing protein 0.0728 0.2914 0.8053
Trypanosoma cruzi beta tubulin, putative 0.0898 0.3618 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0165 0.058 0.0573
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0185 0.0328
Schistosoma mansoni hypothetical protein 0.011 0.0352 0.0625
Mycobacterium tuberculosis Probable reductase 0.0112 0.0364 0.3989
Echinococcus granulosus tubulin alpha 3 chain 0.0683 0.2727 0.4838
Leishmania major beta tubulin 0.0898 0.3618 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0683 0.2727 0.7537
Schistosoma mansoni transcription factor LCR-F1 0.0294 0.1115 0.1981
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0025
Echinococcus granulosus GPCR family 2 0.0031 0.0027 0.0035
Echinococcus granulosus Tubulin beta 2C chain 0.0898 0.3618 0.6421
Onchocerca volvulus 0.0054 0.0123 0.0592
Echinococcus multilocularis tubulin delta chain 0.0242 0.0899 0.0892
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0041 0.007 0.017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0416 0.4573
Loa Loa (eye worm) hypothetical protein 0.0301 0.1144 0.3157
Onchocerca volvulus 0.01 0.0311 0.1529
Echinococcus multilocularis chromobox protein 1 0.0073 0.0199 0.0192
Entamoeba histolytica hypothetical protein 0.0294 0.1115 0.3066
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0054 0.0136
Plasmodium falciparum alpha tubulin 2 0.0683 0.2727 0.7533
Echinococcus granulosus intermediate filament protein 0.0054 0.0123 0.0207
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0054 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0054 0.0506
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0137 0.0465 0.1277
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0054 0.0506
Brugia malayi Nuclear hormone receptor E75 0.0062 0.0154 0.0398
Schistosoma mansoni tubulin subunit delta 0.0242 0.0899 0.1596
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0055 0.014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0157 0.0549 0.0975
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.008 0.0375
Brugia malayi hypothetical protein 0.0075 0.0209 0.0549
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0199 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0242 0.0899 0.2475
Leishmania major delta tubulin, putative 0.0242 0.0899 0.2475
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0054 0.0047
Schistosoma mansoni cpg binding protein 0.0032 0.0029 0.0052
Brugia malayi 6-phosphofructokinase 0.0113 0.0367 0.0989
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0055 0.0523
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0055 0.0123
Toxoplasma gondii exonuclease III APE 0.0038 0.0055 0.0129
Loa Loa (eye worm) hypothetical protein 0.0085 0.0251 0.0686
Trichomonas vaginalis chromobox protein, putative 0.0044 0.008 0.0208
Mycobacterium leprae Probable lipase LipE 0.0038 0.0054 0.0549
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0055 0.014
Schistosoma mansoni zinc finger protein 0.0062 0.0154 0.0274
Brugia malayi tubulin alpha-2 chain 0.0683 0.2727 0.7531
Echinococcus granulosus beta tubulin 0.0898 0.3618 0.6421
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0185 0.0328
Giardia lamblia PHD finger protein 15 0.0033 0.0036 0.007
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0201 0.2159
Echinococcus granulosus peregrin 0.0046 0.0088 0.0145
Schistosoma mansoni hypothetical protein 0.0033 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Schistosoma mansoni hypothetical protein 0.0294 0.1115 0.1981
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0009 0.0011
Schistosoma mansoni ap endonuclease 0.0038 0.0055 0.0098
Brugia malayi conserved hypotetical protein 0.0062 0.0154 0.0398
Brugia malayi hypothetical protein 0.0049 0.0101 0.025
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0185 0.0488
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0011 0.0006
Schistosoma mansoni protein phosphatase 2C 0.0041 0.007 0.0124
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0036 0.0064
Loa Loa (eye worm) tubulin beta-4 chain 0.0898 0.3618 1
Onchocerca volvulus 0.0062 0.0154 0.0747
Echinococcus granulosus Tubulin beta 2C chain 0.0898 0.3618 0.6421
Schistosoma mansoni jun-related protein 0.0071 0.0193 0.0343
Echinococcus granulosus tubulin gamma 1 chain 0.0557 0.2202 0.3904
Schistosoma mansoni ap endonuclease 0.0038 0.0055 0.0098
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0199 0.0538
Trypanosoma brucei alpha tubulin 0.0683 0.2727 0.7533
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0019 0.0044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0027 0.0044
Echinococcus granulosus jumonji domain containing protein 0.0046 0.009 0.0147
Brugia malayi Tubulin beta chain 0.0315 0.1202 0.3303
Echinococcus multilocularis lysine specific demethylase 5A 0.0155 0.0542 0.0535
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0046 0.0087 0.0885
Plasmodium falciparum phd finger protein, putative 0.0033 0.0036 0.0075
Brugia malayi Isocitrate dehydrogenase 0.0112 0.0363 0.0975
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0027 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.003 0.0041
Loa Loa (eye worm) hypothetical protein 0.0137 0.0465 0.1277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0185 0.1978
Schistosoma mansoni tubulin subunit beta 0.0898 0.3618 0.6426
Schistosoma mansoni hypothetical protein 0.0071 0.0193 0.0343
Loa Loa (eye worm) hypothetical protein 0.0067 0.0176 0.0478
Loa Loa (eye worm) alpha-tubulin 0.0683 0.2727 0.7537
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0154 0.0274
Onchocerca volvulus 0.0044 0.0079 0.0372
Echinococcus multilocularis muscleblind protein 1 0.0301 0.1144 0.1138
Echinococcus multilocularis Tubulin alpha 1 chain 0.0683 0.2727 0.2722
Schistosoma mansoni lamin 0.0054 0.0123 0.0219
Brugia malayi dihydrofolate reductase family protein 0.0046 0.0087 0.0213
Echinococcus granulosus ecdysone induced protein 78C 0.0137 0.0465 0.0814
Plasmodium falciparum JmjC domain-containing protein, putative 0.0041 0.007 0.017
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0025 0.0045
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0112 0.0363 0.0644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0137 0.0465 0.1277
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0123 0.0333
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Loa Loa (eye worm) hypothetical protein 0.0062 0.0154 0.0419
Loa Loa (eye worm) hypothetical protein 0.0075 0.0209 0.0569
Echinococcus granulosus dihydrofolate reductase 0.0046 0.0087 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.0465 0.1258
Plasmodium vivax delta tubulin, putative 0.0242 0.0899 0.2466
Loa Loa (eye worm) alpha-tubulin 0.0683 0.2727 0.7537
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0168 0.0453
Leishmania major beta tubulin 0.0898 0.3618 1
Trypanosoma brucei trypanothione reductase 0.0049 0.0102 0.026
Loa Loa (eye worm) dihydrofolate reductase 0.0046 0.0087 0.0234
Schistosoma mansoni jumonji domain containing protein 0.0202 0.0733 0.1302
Onchocerca volvulus 0.0095 0.0291 0.1427
Echinococcus multilocularis Tubulin beta 2C chain 0.0898 0.3618 0.3613
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0304 0.0813
Brugia malayi Cytochrome P450 family protein 0.0039 0.0062 0.0141
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0054 0.0125
Brugia malayi nuclear receptor NHR-67 0.0062 0.0154 0.0398
Leishmania major alpha tubulin 0.0683 0.2727 0.7535
Schistosoma mansoni smad1 5 8 and 0.005 0.0104 0.0185
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0046 0.0087 0.0926
Leishmania major beta tubulin 0.0898 0.3618 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0185 0.0316
Echinococcus multilocularis jun protein 0.0088 0.0261 0.0254
Plasmodium falciparum histone acetyltransferase GCN5 0.0119 0.0391 0.1059
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0168 0.0287
Plasmodium falciparum thioredoxin reductase 0.0049 0.0102 0.026
Schistosoma mansoni tubulin subunit alpha 0.0683 0.2727 0.4844
Echinococcus granulosus nuclear receptor nhr 48 0.0062 0.0154 0.0262
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.003 0.0023
Leishmania major trypanothione reductase 0.0049 0.0102 0.0271

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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