Detailed information for compound 1439172

Basic information

Technical information
  • TDR Targets ID: 1439172
  • Name: N-(2-propan-2-ylphenyl)pyridine-3-carboxamide
  • MW: 240.3 | Formula: C15H16N2O
  • H donors: 1 H acceptors: 2 LogP: 2.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccnc1)Nc1ccccc1C(C)C
  • InChi: 1S/C15H16N2O/c1-11(2)13-7-3-4-8-14(13)17-15(18)12-6-5-9-16-10-12/h3-11H,1-2H3,(H,17,18)
  • InChiKey: WJXAGTBMGIGRJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-isopropylphenyl)pyridine-3-carboxamide
  • N-(2-isopropylphenyl)-3-pyridinecarboxamide
  • N-(2-isopropylphenyl)nicotinamide
  • AK-968/11368772
  • Oprea1_349312
  • MLS000072246
  • ZINC00311888
  • N-(2-Isopropyl-phenyl)-nicotinamide
  • Oprea1_507834
  • ST060536
  • SMR000009116
  • BAS 00540933

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.017 0.0344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0346 0.0346
Echinococcus granulosus cpg binding protein 0.0034 0.005 0.0048
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0666 0.2425 0.5274
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0159 0.0399
Entamoeba histolytica hypothetical protein 0.0178 0.0594 0.1334
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1091 0.402 0.8853
Echinococcus granulosus RUN 0.0021 0.0004 0.0001
Brugia malayi RNA binding protein 0.0204 0.0691 0.0688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0288 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0449 0.7507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.0889 0.1839
Loa Loa (eye worm) hypothetical protein 0.0434 0.1553 0.2996
Loa Loa (eye worm) hypothetical protein 0.0329 0.116 0.2238
Loa Loa (eye worm) hypothetical protein 0.011 0.0337 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.1727 0.3714
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0104 0.0199
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0023 0.0045
Echinococcus multilocularis neuropeptide receptor A26 0.1496 0.5542 0.5541
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0057 0.0165
Mycobacterium ulcerans hypothetical protein 0.0112 0.0346 0.7626
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1091 0.402 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0067 0.0067
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0031 0.006
Mycobacterium leprae conserved hypothetical protein 0.0178 0.0594 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0167 0.0337
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0158 0.0158
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0253 0.0874 0.0861
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0313 0.1144
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0079 0.0077
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0405 0.1443 0.3158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1229 0.4539 1
Mycobacterium tuberculosis Conserved protein 0.0112 0.0346 0.1273
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0654 0.2379 0.2376
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0057 0.0741
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0346 0.1273
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.0999 0.2426
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0104 0.1158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0274 0.0271
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0178 0.0594 0.128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0346 0.1273
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0167 0.0167
Trichomonas vaginalis esterase, putative 0.0112 0.0346 0.0625
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.0668
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0158 0.0155
Plasmodium vivax hypothetical protein 0.0178 0.0594 0.6778
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0346 0.1273
Brugia malayi beta-lactamase family protein 0.0112 0.0346 0.0343
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.017 0.0167
Schistosoma mansoni alpha-glucosidase 0.0147 0.0476 0.0476
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2683 1 1
Echinococcus granulosus muscleblind protein 0.0329 0.116 0.1158
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0013 0.0011
Echinococcus granulosus L aminoadipate semialdehyde 0.0171 0.0565 0.0563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0053 0.0038
Trypanosoma brucei unspecified product 0.0043 0.0085 0.0156
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0898 0.3298 0.8174
Schistosoma mansoni hypothetical protein 0.0354 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0045
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.0999 1
Trichomonas vaginalis conserved hypothetical protein 0.0533 0.1924 0.4153
Loa Loa (eye worm) hypothetical protein 0.0171 0.0565 0.109
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0053 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0737 0.269 0.5866
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0253 0.0874 0.0872
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0253 0.0874 0.2365
Brugia malayi CXXC zinc finger family protein 0.003 0.0037 0.0033
Echinococcus multilocularis Zinc finger, PHD finger 0.0253 0.0874 0.0872
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0898 0.3298 0.3288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0158 0.0143
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0346 0.0344
Onchocerca volvulus 0.0026 0.0023 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0066 0.0052
Schistosoma mansoni rab6-interacting 0.0021 0.0004 0.0004
Schistosoma mansoni alpha-glucosidase 0.0147 0.0476 0.0476
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0336 0.1185 0.2587
Loa Loa (eye worm) hypothetical protein 0.0062 0.0158 0.0304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.017 0.3578
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0691 0.0691
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.048 0.1727 0.1724
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0158 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0313 0.1144
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0646 0.2348 0.4531
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0004 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0073 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.011 0.0337 0.0334
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0158 0.0231
Echinococcus multilocularis musashi 0.0026 0.0023 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0023 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0346 0.0668
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0167 0.0163
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0067 0.0067
Echinococcus multilocularis RUN 0.0021 0.0004 0.0001
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0184 0.0355
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0253 0.0874 0.0874
Echinococcus multilocularis muscleblind protein 0.0329 0.116 0.1158
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1552 0.5752 0.5752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3353 0.7348
Loa Loa (eye worm) hypothetical protein 0.0394 0.1405 0.2711
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0202 0.0188
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0288 0.0285
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0167 0.0254
Brugia malayi PHD-finger family protein 0.0026 0.0022 0.0019
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0405 0.1443 0.3079
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0158 0.0316
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0104 0.1158
Schistosoma mansoni lipoxygenase 0.0021 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.017 0.3578
Loa Loa (eye worm) RNA binding protein 0.0204 0.0691 0.1334
Brugia malayi hypothetical protein 0.012 0.0375 0.0371
Schistosoma mansoni hypothetical protein 0.0024 0.0014 0.0014
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0637 0.2316 0.2314
Mycobacterium leprae Probable lipase LipE 0.0112 0.0346 0.5725
Onchocerca volvulus Huntingtin homolog 0.012 0.0375 0.1385
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0274 0.0995
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0898 0.3298 0.7225
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0073 0.0129
Trypanosoma cruzi target of rapamycin kinase 3 0.1012 0.3725 0.3716
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0053 0.0101
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.017 0.0167
Schistosoma mansoni cytochrome P450 0.0024 0.0014 0.0014
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0637 0.2316 0.2314
Leishmania major cathepsin L-like protease 0.0074 0.0202 0.0416
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0073 0.0015
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0104 0.2068
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0253 0.0874 0.0874
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0346 0.1273
Brugia malayi Cytochrome P450 family protein 0.0034 0.0053 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0158 0.0154
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0178 0.0594 0.0594
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0594 0.1145
Echinococcus multilocularis microtubule associated protein 2 0.0744 0.2719 0.2717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0933 0.3429 0.7518
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0056 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0288 0.0286
Onchocerca volvulus 0.0176 0.0583 0.2164
Onchocerca volvulus 0.0026 0.0023 0.0074
Schistosoma mansoni cpg binding protein 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.0668
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.048 0.1727 0.1715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0638 0.2319 0.5036
Echinococcus multilocularis muscleblind protein 1 0.0329 0.116 0.1158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0533 0.1924 0.3712
Plasmodium falciparum thioredoxin reductase 0.0041 0.0077 0.0847
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1091 0.402 0.4018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.3724 0.8178
Onchocerca volvulus 0.0434 0.1553 0.5783
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.048 0.1727 0.1725
Loa Loa (eye worm) phosphatidylinositol kinase 0.0178 0.0594 0.1145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0158 0.0143
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0178 0.0594 0.0591
Brugia malayi TAR-binding protein 0.0204 0.0691 0.0688
Loa Loa (eye worm) hypothetical protein 0.0049 0.0108 0.0208
Echinococcus granulosus tar DNA binding protein 0.0204 0.0691 0.0689
Giardia lamblia GTOR 0.1091 0.402 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1091 0.402 0.4011
Onchocerca volvulus 0.0178 0.0594 0.2202
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0158 0.0316
Echinococcus granulosus neuropeptide s receptor 0.1496 0.5542 0.5541
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0053 0.0101
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0158 0.3292
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0004 0.0001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0077 0.0241
Schistosoma mansoni fkbp-rapamycin associated protein 0.048 0.1727 0.1727
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0253 0.0874 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0835 0.3058 0.6688
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0565 0.109
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0346 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0875 0.3208 0.7026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0066 0.0128
Loa Loa (eye worm) inositol-1 0.004 0.0073 0.0141
Brugia malayi Pre-SET motif family protein 0.0646 0.2348 0.2346
Onchocerca volvulus 0.003 0.0037 0.0124
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0079 0.0077
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0875 0.3208 0.7947
Leishmania major cathepsin L-like protease 0.0074 0.0202 0.0416
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0202 0.0188
Giardia lamblia Hypothetical protein 0.0178 0.0594 0.141
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0691 0.0691
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0346 0.0625
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0178 0.0594 0.1179
Loa Loa (eye worm) phosphatidylinositol 3 0.0226 0.0774 0.1493
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0147 0.0144
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0178 0.0594 0.058
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0031 0.0029
Leishmania major DNA polymerase eta, putative 0.0062 0.0158 0.0316
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.0999 0.2359
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1091 0.402 0.402
Loa Loa (eye worm) hypothetical protein 0.0354 0.1254 0.242
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0104 0.2068
Loa Loa (eye worm) hypothetical protein 0.0329 0.116 0.2238
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0158 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0271 0.0257
Leishmania major phosphatidylinositol 3-kinase, putative 0.0253 0.0874 0.19
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0073 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.1091 0.402 0.884
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0178 0.0594 0.0594
Brugia malayi RNA recognition motif domain containing protein 0.0204 0.0691 0.0688
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0066 0.0064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0073 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0158 0.0143
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0158 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0073 0.0015
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0178 0.0594 0.1593
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0013 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0053 0.0101
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.0668
Schistosoma mansoni inositol monophosphatase 0.004 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0638 0.2319 0.5036
Mycobacterium tuberculosis Probable reductase 0.0093 0.0274 0.0995
Mycobacterium tuberculosis Conserved protein 0.0112 0.0346 0.1273
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0031 0.0046
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0037
Leishmania major cathepsin L-like protease 0.0074 0.0202 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.048 0.1727 0.1715
Plasmodium falciparum phd finger protein, putative 0.0029 0.0031 0.0319
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0253 0.0874 0.1806
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1091 0.402 0.4018
Onchocerca volvulus 0.0112 0.0346 0.1278
Echinococcus granulosus dna polymerase kappa 0.0062 0.0158 0.0155
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0253 0.0874 0.1806
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0143 0.0129
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.0668
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0007
Leishmania major hypothetical protein, conserved 0.0112 0.0346 0.0733
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0346 0.0332
Echinococcus granulosus geminin 0.0364 0.129 0.1287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0658 0.2393 0.5203
Entamoeba histolytica protein kinase rad3, putative 0.048 0.1727 0.4201
Entamoeba histolytica hypothetical protein 0.0178 0.0594 0.1334
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0439 0.1572 0.1569
Echinococcus granulosus peregrin 0.0031 0.004 0.0038
Leishmania major hypothetical protein, unknown function 0.0178 0.0594 0.128
Schistosoma mansoni microtubule-associated protein tau 0.0744 0.2719 0.2719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Brugia malayi hypothetical protein 0.0176 0.0583 0.058
Trichomonas vaginalis set domain proteins, putative 0.0735 0.2683 0.585
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0253 0.0874 0.1806
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0337 0.0337
Echinococcus multilocularis geminin 0.0364 0.129 0.1287
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0405 0.1443 0.3079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Brugia malayi Bromodomain containing protein 0.0038 0.0065 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.1058 0.2217
Entamoeba histolytica hypothetical protein 0.0747 0.2729 0.6734
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0178 0.0594 0.6778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0565 0.0563
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0158 0.0549
Echinococcus granulosus lamin 0.0026 0.0023 0.0021
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0167 0.0337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0274 0.0274
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2683 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0313 0.1144
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0031 0.0031
Onchocerca volvulus 0.0171 0.0565 0.2095
Brugia malayi Bromodomain containing protein 0.0031 0.004 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3354 0.7351
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0178 0.0594 0.6778
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0898 0.3298 0.7225
Loa Loa (eye worm) hypothetical protein 0.0043 0.0087 0.0169
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0565 0.0562
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.3724 0.8178
Toxoplasma gondii thioredoxin reductase 0.0041 0.0077 0.0173
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0158 0.0204
Schistosoma mansoni intermediate filament proteins 0.0026 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0933 0.3429 0.7518
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0073 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0354 0.1254 0.2656
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.1727 0.3714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3353 0.7348
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0048 0.0104 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0898 0.3298 0.3288
Schistosoma mansoni cpg binding protein 0.0034 0.005 0.005
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0104 0.0247
Brugia malayi Cytochrome P450 family protein 0.0034 0.0053 0.0049
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1091 0.402 0.4018
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0004 0.0001
Brugia malayi hypothetical protein 0.0434 0.1553 0.155
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0158 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0013 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0405 0.1443 0.144
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0178 0.0594 0.0594
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0073 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3354 0.7351
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0031 0.0046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0313 0.5147
Loa Loa (eye worm) hypothetical protein 0.0176 0.0583 0.1126
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0167 0.0322
Onchocerca volvulus 0.0099 0.0295 0.1087
Schistosoma mansoni polycystin 1-related 0.0021 0.0004 0.0004
Leishmania major trypanothione reductase 0.0041 0.0077 0.0139
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1091 0.402 0.8853
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0354 0.1254 0.1252
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0171 0.0565 0.0565
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0065 0.0062
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0253 0.0874 0.2043
Schistosoma mansoni hypothetical protein 0.0364 0.129 0.129
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0594 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.0594 0.059
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0226 0.0774 0.076
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0067 0.013
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0666 0.2425 0.5274
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.072 0.2628 0.648
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0056 0.0054
Loa Loa (eye worm) hypothetical protein 0.0178 0.0594 0.1145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.0594 0.059
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0253 0.0874 0.19
Brugia malayi Cytochrome P450 family protein 0.0024 0.0014 0.0011
Trypanosoma brucei trypanothione reductase 0.0041 0.0077 0.0139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.017 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.1091 0.402 0.884
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0158 0.0549
Loa Loa (eye worm) phosphatidylinositol 3 0.1401 0.5183 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0048 0.0104 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.0594 0.059
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0346 0.1273
Plasmodium vivax glutathione reductase, putative 0.0041 0.0077 0.0847
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0252 0.0487
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.011 0.0337 0.0334
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0178 0.0594 0.128
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0275 0.0273
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0202 0.0188
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0104 0.0199
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.0668
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0594 0.1145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0637 0.2316 0.4468
Loa Loa (eye worm) glutathione reductase 0.0041 0.0077 0.0149
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0747 0.2729 0.6734
Brugia malayi cytochrome P450 0.0024 0.0014 0.0011
Giardia lamblia DINP protein human, muc B family 0.0062 0.0158 0.0317
Trypanosoma brucei unspecified product 0.0062 0.0158 0.0316
Toxoplasma gondii target of rapamycin (TOR), putative 0.0992 0.3649 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0405 0.1443 0.1443
Brugia malayi beta-lactamase family protein 0.0112 0.0346 0.0343
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0065 0.0062
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0066 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.3724 0.8178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Echinococcus granulosus intermediate filament protein 0.0026 0.0023 0.0021
Echinococcus multilocularis Protein lozenge 0.0054 0.0128 0.0126
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0167 0.0164
Mycobacterium tuberculosis Conserved protein 0.0112 0.0346 0.1273
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0274 0.0995
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0031 0.0319
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0898 0.3298 0.7225
Echinococcus multilocularis neuropeptide s receptor 0.1496 0.5542 0.5541
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0405 0.1443 0.1431
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0611 0.222 0.4875
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0158 0.0204
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0405 0.1443 0.3483
Echinococcus granulosus dna polymerase eta 0.0062 0.0158 0.0155
Schistosoma mansoni hypothetical protein 0.0178 0.0594 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0066 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0346 0.1273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0288 0.0286
Leishmania major DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1552 0.5752 0.5751
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0465 0.0898
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0085 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Loa Loa (eye worm) beta-lactamase 0.0112 0.0346 0.0668
Schistosoma mansoni DNA polymerase eta 0.0062 0.0158 0.0158
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0066 0.0063
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0594 0.1145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0346 0.0346
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0014 0.0012
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0104 0.0247
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0594 0.0591
Loa Loa (eye worm) cytochrome P450 0.0024 0.0014 0.0028
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0253 0.0874 0.0872
Echinococcus multilocularis 0.0024 0.0014 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.012 0.0375 0.0723
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0202 0.0188
Brugia malayi Pre-SET motif family protein 0.0093 0.0274 0.027
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.033 0.1163 0.2837
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1091 0.402 0.8853
Echinococcus multilocularis tar DNA binding protein 0.0204 0.0691 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.3724 0.8178
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0533 0.1924 0.5254
Loa Loa (eye worm) phosphatidylinositol 3 0.1091 0.402 0.7756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0835 0.3058 0.6688
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.048 0.1727 0.3786
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.0999 0.2359
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0346 0.0344
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0077 0.0847
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0302 0.1058 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.1229 0.4539 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0085 0.0156
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0178 0.0594 0.1593
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0288 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0041
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0354 0.1254 0.1252
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0147 0.0144
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0178 0.0164
Loa Loa (eye worm) hypothetical protein 0.0394 0.1405 0.2711
Brugia malayi Inositol-1 0.004 0.0073 0.0069
Plasmodium vivax SET domain protein, putative 0.0093 0.0274 0.3106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0346 0.7626
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0465 0.0898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0835 0.3058 0.6688
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0449 0.1669
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0346 0.0332
Brugia malayi Bromodomain containing protein 0.0075 0.0206 0.0203
Entamoeba histolytica hypothetical protein 0.048 0.1727 0.4201
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0594 0.1145
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0085 0.0156
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0514 0.1856 0.4575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0835 0.3058 0.6688
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0031 0.0029
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0178 0.0594 0.6778
Echinococcus multilocularis L aminoadipate semialdehyde 0.0171 0.0565 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0259 0.0256
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0346 0.0625
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0449 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0253 0.0874 0.0872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3354 0.7351
Onchocerca volvulus 0.0735 0.2683 1
Echinococcus multilocularis cpg binding protein 0.0034 0.005 0.0048
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2683 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0274 0.0274
Echinococcus granulosus microtubule associated protein 2 0.0744 0.2719 0.2717
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0053 0.0877
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0594 0.0591
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.017 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0898 0.3298 0.3295
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0143
Brugia malayi glutathione reductase 0.0041 0.0077 0.0074
Onchocerca volvulus 0.0112 0.0346 0.1278
Loa Loa (eye worm) hypothetical protein 0.0079 0.0219 0.0423
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0835 0.3058 0.6726
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0104 0.0345
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0178 0.0594 0.058
Plasmodium vivax hypothetical protein, conserved 0.0178 0.0594 0.6778
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0158 0.0158
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0171 0.0565 0.0562
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0439 0.1572 0.1569
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0178 0.0594 0.1334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0346 0.0733
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0274 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.3724 0.8178
Onchocerca volvulus 0.0093 0.0274 0.1009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0637 0.2316 0.2313
Echinococcus granulosus serine:threonine protein kinase SMG1 0.048 0.1727 0.1725
Giardia lamblia Phosphatidylinositol 4-kinase 0.0178 0.0594 0.141
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0405 0.1443 0.3483
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0077 0.0149
Schistosoma mansoni alpha glucosidase 0.0038 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0126
Loa Loa (eye worm) hypothetical protein 0.0261 0.0906 0.1748
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1012 0.3725 0.8201
Entamoeba histolytica hypothetical protein 0.0178 0.0594 0.1334
Toxoplasma gondii ABC1 family protein 0.0112 0.0346 0.0912
Onchocerca volvulus 0.0112 0.0346 0.1278
Loa Loa (eye worm) TAR-binding protein 0.0204 0.0691 0.1334
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0178 0.0594 0.6778
Loa Loa (eye worm) phosphatidylinositol 3 0.1229 0.4539 0.8757
Trichomonas vaginalis PIKK family atypical protein kinase 0.071 0.259 0.5643
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.048 0.1727 0.1727
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0167 0.0153
Leishmania major phosphatidylinositol kinase related protein, putative 0.0178 0.0594 0.128
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0253 0.0874 0.2365
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0158 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0288 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0638 0.2319 0.5036
Brugia malayi intermediate filament protein 0.0026 0.0023 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0253 0.0874 0.2043
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0104 0.1552
Trypanosoma brucei unspecified product 0.0043 0.0085 0.0156
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0274 0.0995
Brugia malayi jmjC domain containing protein 0.0038 0.0067 0.0064
Brugia malayi jmjC domain containing protein 0.0094 0.0275 0.0272
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0073 0.0059
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0346 0.1273
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0066 0.0052
Onchocerca volvulus 0.0178 0.0594 0.2202
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0288 0.0556
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0999 0.2086
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0253 0.0874 0.1686
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0158 0.0143
Echinococcus granulosus neuropeptide receptor A26 0.1496 0.5542 0.5541
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0274 0.4474
Echinococcus granulosus serine protein kinase ATM 0.048 0.1727 0.1725
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0004 0.0001
Echinococcus multilocularis 0.0178 0.0594 0.0591
Loa Loa (eye worm) hypothetical protein 0.048 0.1727 0.3332
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0158 0.0316
Trypanosoma brucei glucosidase, putative 0.0038 0.0066 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0346 0.3933
Onchocerca volvulus Huntingtin homolog 0.012 0.0375 0.1385
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0253 0.0874 0.0871
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0073 0.0017
Schistosoma mansoni lozenge 0.0054 0.0128 0.0128
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0077 0.0063
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1091 0.402 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0346 0.0343
Echinococcus multilocularis lamin dm0 0.0026 0.0023 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.015 0.0148
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0565 0.0563
Onchocerca volvulus Alhambra homolog 0.0029 0.0031 0.0104
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0178 0.0594 0.6778
Loa Loa (eye worm) hypothetical protein 0.012 0.0375 0.0723
Schistosoma mansoni hypothetical protein 0.0029 0.0031 0.0031
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0178 0.0594 0.058
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0053 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.1058 0.2217
Schistosoma mansoni lamin 0.0026 0.0023 0.0023
Schistosoma mansoni lipoxygenase 0.0059 0.0147 0.0147
Leishmania major phosphatidylinositol 3-kinase, putative 0.0835 0.3058 0.6726
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0004 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.017 0.3578
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0004 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0274 0.0995
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0594 0.0591
Leishmania major phosphatidylinositol 4-kinase, putative 0.0178 0.0594 0.128
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0346 0.7626
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0253 0.0874 0.19
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.3649 0.801
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0718 0.2619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3353 0.7348
Leishmania major cytochrome p450-like protein 0.0034 0.0053 0.0084
Mycobacterium ulcerans beta-lactamase 0.0112 0.0346 0.7626
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0037 0.0071
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0485 0.1747 0.4251
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1091 0.402 0.4011
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Brugia malayi Cytochrome P450 family protein 0.0087 0.0252 0.0249
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.017 0.017
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0405 0.1443 0.3079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.3354 0.7351
Echinococcus granulosus jumonji domain containing protein 0.004 0.0073 0.0071
Brugia malayi MH2 domain containing protein 0.0144 0.0465 0.0462
Schistosoma mansoni bromodomain containing protein 0.0064 0.0163 0.0163
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2683 1 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0073 0.0071
Leishmania major hypothetical protein, conserved 0.0271 0.094 0.2046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0594 0.1179
Toxoplasma gondii FATC domain-containing protein 0.048 0.1727 0.4713
Schistosoma mansoni hypothetical protein 0.0364 0.129 0.129
Trichomonas vaginalis PIKK family atypical protein kinase 0.1091 0.402 0.884
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.017 0.0428
Plasmodium falciparum glutathione reductase 0.0041 0.0077 0.0847
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0023 0.0045
Schistosoma mansoni loxhd1 0.0021 0.0004 0.0004
Loa Loa (eye worm) runx1 0.0054 0.0128 0.0248
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0158 0.0155
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0275 0.0273
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0146 0.0281
Schistosoma mansoni lamin 0.0026 0.0023 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0203 0.0203
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0167 0.0153
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0178 0.0594 0.058
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1552 0.5752 0.5751
Loa Loa (eye worm) hypothetical protein 0.0434 0.1553 0.2996
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0158 0.0316
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.015 0.0148
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0346 0.5725
Brugia malayi Muscleblind-like protein 0.0329 0.116 0.1157
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0067 0.0065
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0178 0.0594 0.058
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0691 0.0691
Echinococcus granulosus lamin dm0 0.0026 0.0023 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0346 0.0625
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0158 0.3292
Echinococcus multilocularis lamin 0.0026 0.0023 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0202 0.0416
Brugia malayi FAT domain containing protein 0.0354 0.1254 0.1251
Schistosoma mansoni zinc finger protein 0.0021 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0691 0.0691
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0176 0.0176
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0073 0.1346
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0565 0.0563
Brugia malayi PHD-finger family protein 0.0029 0.0031 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0594 0.1179
Leishmania major phosphatidylinositol kinase, putative 0.0178 0.0594 0.128
Loa Loa (eye worm) hypothetical protein 0.0302 0.1058 0.2041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.006
Entamoeba histolytica hypothetical protein 0.0048 0.0104 0.0096
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0167 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0288 0.0286
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1229 0.4539 1
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0073 0.007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1012 0.3725 0.8201
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0158 0.0304
Schistosoma mansoni inositol monophosphatase 0.004 0.0073 0.0073
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0178 0.0594 0.1593
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2683 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0204 0.0691 0.1334
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0346 0.0625
Schistosoma mansoni rab6-interacting 0.0021 0.0004 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.048 0.1727 0.1724
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.0668
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0274 0.0995
Brugia malayi beta-lactamase 0.0112 0.0346 0.0343
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0178 0.0594 0.1179
Echinococcus multilocularis dna polymerase eta 0.0062 0.0158 0.0155
Brugia malayi Thioredoxin reductase 0.0041 0.0077 0.0074
Mycobacterium ulcerans lipase LipD 0.0112 0.0346 0.7626
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.0594 0.2223
Echinococcus multilocularis serine protein kinase ATM 0.048 0.1727 0.1725
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0066 0.0115
Echinococcus multilocularis peregrin 0.0031 0.004 0.0038
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0054 0.0051
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1091 0.402 0.8853
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0253 0.0874 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0253 0.0874 0.0861

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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