Detailed information for compound 1455368

Basic information

Technical information
  • TDR Targets ID: 1455368
  • Name: tert-butyl N-[(4-propylcyclohexylidene)amino] carbamate
  • MW: 254.368 | Formula: C14H26N2O2
  • H donors: 1 H acceptors: 1 LogP: 3.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC1CC/C(=N/NC(=O)OC(C)(C)C)/CC1
  • InChi: 1S/C14H26N2O2/c1-5-6-11-7-9-12(10-8-11)15-16-13(17)18-14(2,3)4/h11H,5-10H2,1-4H3,(H,16,17)/b15-12-
  • InChiKey: PKJUTNWMZUGLIA-QINSGFPZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(4-propylcyclohexylidene)amino]carbamic acid tert-butyl ester
  • MLS000390913
  • SMR000259950
  • T0507-7588
  • ZINC04934211

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0066 0.0066
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0009 0.0009
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0023 0.0573
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Brugia malayi Muscleblind-like protein 0.033 0.0391 0.0391
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.0309 0.0638
Loa Loa (eye worm) hypothetical protein 0.0057 0.0054 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0034 0.0034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0054 0.0054
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0004 0.088
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0025 0.0014 0.0176
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0034 0.0791
Trichomonas vaginalis heat shock protein, putative 0.0046 0.004 0.0506
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.0192 0.0192
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0034 0.4854
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0034 0.0437
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0047 0.1171
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0024 0.0013 0.0013
Schistosoma mansoni lipoxygenase 0.0135 0.015 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Toxoplasma gondii Hsp90 domain-containing protein 0.0184 0.0211 0.5256
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) Smad1 0.0018 0.0005 0.0005
Brugia malayi TAR-binding protein 0.0067 0.0066 0.0066
Toxoplasma gondii ABC1 family protein 0.0041 0.0034 0.0849
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0034 0.0437
Chlamydia trachomatis replicative DNA helicase 0.0443 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0089 0.0089
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0011 0.0011
Brugia malayi MH1 domain containing protein 0.0018 0.0005 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0066 0.0066
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0014 0.0176
Giardia lamblia Heat shock protein HSP 90-alpha 0.0049 0.0043 0.0553
Trichomonas vaginalis esterase, putative 0.0041 0.0034 0.0437
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0362 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Echinococcus granulosus Smad4 0.0018 0.0005 0.0005
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0023 0.0534
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0047 0.0602
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0043 1
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0018 0.0231
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0032 0.0023 0.0295
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Echinococcus multilocularis endoplasmin 0.0046 0.004 0.004
Brugia malayi hypothetical protein 0.0033 0.0024 0.0024
Trypanosoma cruzi ISWI complex protein 0.0018 0.0006 0.0841
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0005
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0025 0.0014 0.0014
Echinococcus granulosus microtubule associated protein 2 0.1473 0.1805 0.1805
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0542
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0066 0.0066
Brugia malayi Blistered cuticle protein 3 0.003 0.002 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Brugia malayi beta-lactamase 0.0041 0.0034 0.0034
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0047 0.1091
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0005 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0027 0.0016 0.3738
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Schistosoma mansoni heat shock protein 0.0032 0.0023 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0016 0.23
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0016 0.23
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0005 0.0005
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0027 0.0342
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0047 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0443 0.0531 1
Brugia malayi CHE-14 protein 0.0093 0.0098 0.0098
Plasmodium vivax endoplasmin, putative 0.0049 0.0043 0.1003
Brugia malayi Animal haem peroxidase family protein 0.003 0.002 0.002
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0014 0.0176
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0071 0.007 0.007
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0025 0.0014 0.0014
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0034 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0081 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis Smad4 0.0018 0.0005 0.0005
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Brugia malayi Animal haem peroxidase family protein 0.003 0.002 0.002
Onchocerca volvulus 0.003 0.002 0.1297
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0005 0.0005
Echinococcus granulosus dnaJ subfamily B 0.0434 0.052 0.052
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0043 0.0553
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0004 0.0004
Leishmania major heat shock protein, putative 0.0032 0.0023 0.5328
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis lamin 0.0031 0.0021 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0034 0.0034
Schistosoma mansoni smad1 5 8 and 0.0018 0.0005 0.0005
Loa Loa (eye worm) animal heme peroxidase 0.003 0.002 0.002
Schistosoma mansoni caspase-7 (C14 family) 0.0033 0.0024 0.0024
Onchocerca volvulus 0.0023 0.0011 0.0703
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Brugia malayi cyclin-dependent kinase 7 homolog 0.0025 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis heat shock protein 0.0049 0.0043 0.0043
Brugia malayi intermediate filament protein 0.0031 0.0021 0.0021
Schistosoma mansoni heat shock protein 0.0049 0.0043 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0034 0.0063
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0025 0.0014 0.0014
Trichomonas vaginalis serine/threonine kinase, putative 0.0025 0.0014 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) blistered cuticle protein 3 0.003 0.002 0.002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0034 0.0034
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0014 0.0176
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0004 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0034 0.0063
Echinococcus multilocularis sentrin specific protease 8 0.0071 0.007 0.007
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0038 0.0492
Schistosoma mansoni hypothetical protein 0.0079 0.0081 0.0081
Echinococcus multilocularis smad 0.0018 0.0005 0.0005
Echinococcus multilocularis geminin 0.0374 0.0446 0.0446
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0098 0.0098
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0135 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0374 0.0446 0.0446
Brugia malayi MH2 domain containing protein 0.0264 0.0309 0.0309
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0071 0.007 0.0899
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0016 0.0375
Brugia malayi beta-lactamase family protein 0.0041 0.0034 0.0034
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0025 0.0014 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0034
Loa Loa (eye worm) MH2 domain-containing protein 0.0264 0.0309 0.0309
Echinococcus granulosus mitogen activated protein kinase 15 0.0025 0.0014 0.0014
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0014 0.0014
Echinococcus multilocularis caspase 2 0.0033 0.0024 0.0024
Plasmodium falciparum endoplasmin, putative 0.0035 0.0027 0.062
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0035 0.4916
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0124 0.0136 0.1964
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0016 0.0402
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0016 0.3738
Echinococcus granulosus smad 0.0018 0.0005 0.0005
Echinococcus granulosus serine:threonine protein kinase haspin 0.0024 0.0013 0.0013
Trypanosoma cruzi Heat shock protein 83, putative 0.0049 0.0043 0.6153
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0043 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0098 0.0098
Brugia malayi CXXC zinc finger family protein 0.003 0.0021 0.0021
Loa Loa (eye worm) animal heme peroxidase 0.003 0.002 0.002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0645 0.0781 1
Schistosoma mansoni rab6-interacting 0.0023 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0025 0.0014 0.3176
Schistosoma mansoni heat shock protein 0.0049 0.0043 0.0043
Schistosoma mansoni endoplasmin 0.0049 0.0043 0.0043
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0021 0.0021
Brugia malayi isocitrate dehydrogenase 0.0017 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0035 0.4916
Schistosoma mansoni protein kinase 0.0025 0.0014 0.0014
Brugia malayi Protein kinase domain containing protein 0.0025 0.0014 0.0014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0004 0.0004
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0011 0.0011
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0005 0.0005
Schistosoma mansoni lipoxygenase 0.0095 0.01 0.01
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0034 0.0063
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0034 0.0437
Onchocerca volvulus Dual oxidase homolog 0.003 0.002 0.1297
Schistosoma mansoni serine/threonine kinase 0.0025 0.0014 0.0014
Trypanosoma brucei Heat shock protein 83, putative 0.0049 0.0043 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0645 0.0781 1
Loa Loa (eye worm) animal heme peroxidase 0.003 0.002 0.002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0066 0.0066
Loa Loa (eye worm) acetyltransferase 0.0169 0.0192 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0021 0.0021
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0038 0.003 0.6977
Schistosoma mansoni hypothetical protein 0.009 0.0094 0.0094
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0011 0.0011
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0004 0.0542
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Brugia malayi Animal haem peroxidase family protein 0.003 0.002 0.002
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0066 0.0066
Echinococcus multilocularis apoptotic protease activating factor 1 0.0033 0.0024 0.0024
Loa Loa (eye worm) haspin protein kinase 0.0024 0.0013 0.0013
Brugia malayi Animal haem peroxidase family protein 0.003 0.002 0.002
Trypanosoma brucei ISWI complex protein 0.0018 0.0006 0.1367
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0115 0.0125 0.0125
Echinococcus multilocularis muscleblind protein 0.033 0.0391 0.0391
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0034 0.0063
Trichomonas vaginalis protein kinase atmrk1, putative 0.0025 0.0014 0.0176
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0025 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Brugia malayi Bromodomain containing protein 0.005 0.0045 0.0045
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0046 0.004 0.0035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0315 0.0373 0.682
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0071 0.007 0.0899
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0016 0.0375
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0071 0.007 0.0899
Schistosoma mansoni smad1 5 8 and 0.0018 0.0005 0.0005
Echinococcus granulosus tar DNA binding protein 0.0067 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0024 0.0013 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0034 0.0437
Toxoplasma gondii heat shock protein 90, putative 0.0049 0.0043 0.1076
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.088
Echinococcus multilocularis RUN 0.0023 0.0011 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0034 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.009 0.0094 0.0094
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis musashi 0.0031 0.0021 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.1473 0.1805 0.1805
Plasmodium vivax heat shock protein, putative 0.0184 0.0211 0.4896
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0057 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0013 0.0013
Onchocerca volvulus 0.0031 0.0021 0.1358
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0098 0.0098
Echinococcus granulosus zinc finger protein 0.0029 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0114 0.0124 0.0124
Leishmania major serine/threonine kinase-like protein, putative 0.0025 0.0014 0.3176
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Echinococcus multilocularis lamin dm0 0.0031 0.0021 0.0021
Onchocerca volvulus Peroxidasin homolog 0.003 0.002 0.1297
Loa Loa (eye worm) hypothetical protein 0.0046 0.004 0.004
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0005 0.0005
Echinococcus granulosus serine:threonine protein kinase NLK 0.0025 0.0014 0.0014
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0005 0.0005
Loa Loa (eye worm) haspin protein kinase 0.0024 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0009 0.0009
Schistosoma mansoni patched 1 0.0093 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis Niemann Pick C1 protein 0.0217 0.0252 0.0252
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.052 0.052
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.8097 1 1
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0034 0.0034
Echinococcus granulosus apoptotic protease activating factor 1 0.0033 0.0024 0.0024
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0038 0.0892
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0315 0.0373 0.0772
Echinococcus granulosus geminin 0.0374 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.0031
Mycobacterium tuberculosis Conserved protein 0.0041 0.0034 0.0063
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0098 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0066 0.0066
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0024 0.0013 0.0013
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0023 0.1469
Plasmodium vivax heat shock protein 86, putative 0.0049 0.0043 0.1003
Echinococcus granulosus Niemann Pick C1 protein 0.0217 0.0252 0.0252
Loa Loa (eye worm) transcription factor SMAD2 0.0264 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Brugia malayi hypothetical protein 0.0079 0.0081 0.0081
Echinococcus granulosus serine:threonine protein kinase haspin 0.0024 0.0013 0.0013
Brugia malayi Smad1 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0217 0.0252 0.0252
Echinococcus multilocularis heat shock protein 90 0.0049 0.0043 0.0043
Echinococcus granulosus RUN 0.0023 0.0011 0.0011
Entamoeba histolytica cell division protein kinase 2, putative 0.0025 0.0014 0.0176
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0066 0.0066
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0043 0.6153
Trypanosoma cruzi heat shock protein 90, putative 0.0049 0.0043 0.6153
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.0192 0.0192
Brugia malayi GSG2 0.0024 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0035 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.0035 0.0026 0.0026
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0009 0.0009
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0025 0.0014 0.1954
Schistosoma mansoni zinc finger protein 0.0018 0.0006 0.0006
Echinococcus multilocularis protein dispatched 1 0.0106 0.0115 0.0115
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0037 0.0037
Brugia malayi MH2 domain containing protein 0.0018 0.0005 0.0005
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0005 0.0005
Schistosoma mansoni lamin 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3566 0.4394 0.9175
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0005 0.0005
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0025 0.0014 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0443 0.0531 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0041 0.0034 0.0063
Onchocerca volvulus 0.003 0.0021 0.1325
Echinococcus granulosus Niemann Pick C1 protein 0.0311 0.0367 0.0367
Echinococcus multilocularis transcription factor eb 0.0115 0.0125 0.0125
Brugia malayi Cell division protein kinase 2 0.0025 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus granulosus heat shock protein 0.0049 0.0043 0.0043
Loa Loa (eye worm) heat shock protein 90 0.0049 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0043 0.6153
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus granulosus lamin dm0 0.0031 0.0021 0.0021
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0063 0.0063
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0038 0.0492
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0005 0.0005
Brugia malayi hypothetical protein 0.0024 0.0013 0.0013
Schistosoma mansoni polycystin 1-related 0.0023 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0011 0.0255
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0054 0.0054
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0009 0.0009
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0443 0.0531 0.3176
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.0183 0.0183
Trypanosoma cruzi DNA repair protein, putative 0.0038 0.003 0.4292
Brugia malayi PHD-finger family protein 0.0036 0.0027 0.0027
Trypanosoma cruzi DNA repair protein, putative 0.0038 0.003 0.4292
Giardia lamblia Fructose-bisphosphate aldolase 0.0645 0.0781 1
Entamoeba histolytica hypothetical protein 0.0079 0.0081 0.1041
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0014 0.0014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.0192 0.0192
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Schistosoma mansoni Replicative DNA helicase 0.0443 0.0531 0.0531
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0004 0.0004
Brugia malayi Niemann-Pick C1 protein precursor 0.0217 0.0252 0.0252
Loa Loa (eye worm) animal heme peroxidase 0.003 0.002 0.002
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0024 0.0013 0.0013
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0098 0.126
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0024
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0023 0.0023
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0011 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma cruzi ISWI complex protein 0.0018 0.0006 0.0841
Onchocerca volvulus Chorion peroxidase homolog 0.003 0.002 0.1297
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3885 0.4789 1
Schistosoma mansoni Smad4 0.0018 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.0014 0.0176
Mycobacterium ulcerans heat shock protein 90 0.0046 0.004 0.0109
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.8097 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) Ulp1 protease 0.0071 0.007 0.007
Onchocerca volvulus 0.0031 0.0021 0.1358
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0217 0.0252 0.3225
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0095
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0014 0.0176
Schistosoma mansoni hypothetical protein 0.0024 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0374 0.0446 0.0446
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0025 0.0014 0.1954
Loa Loa (eye worm) RNA binding protein 0.0067 0.0066 0.0066
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0221 0.0256 0.0256
Echinococcus multilocularis expressed conserved protein 0.0204 0.0236 0.0236
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0011 0.0011
Echinococcus multilocularis zinc finger protein 0.0029 0.0019 0.0019
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0043 0.0553
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0009 0.0009
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0025 0.0014 0.3176
Echinococcus granulosus peroxidasin 0.003 0.002 0.002
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0011 0.0011
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0023 0.5328
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Brugia malayi Doublecortin family protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0034
Loa Loa (eye worm) twinkle helicase 0.0127 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Schistosoma mansoni hypothetical protein 0.8097 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0004 0.0004
Trypanosoma brucei protein kinase, putative 0.0025 0.0014 0.3176
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0042 0.0035 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Brugia malayi RNA binding protein 0.0067 0.0066 0.0066
Schistosoma mansoni loxhd1 0.0023 0.0011 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Giardia lamblia Heat shock protein HSP 90-alpha 0.0042 0.0035 0.0442
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0035 0.0442
Brugia malayi Cell death protein 3 precursor 0.0033 0.0024 0.0024
Plasmodium falciparum heat shock protein 90 0.0049 0.0043 0.1003
Echinococcus granulosus GPCR family 2 0.0018 0.0005 0.0005
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0043 0.6153
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0047 0.1171
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.009 0.0094 0.0094
Brugia malayi beta-lactamase family protein 0.0041 0.0034 0.0034
Loa Loa (eye worm) endoplasmin 0.0049 0.0043 0.0043
Chlamydia trachomatis recombinase RecA 0.0124 0.0136 0.2562
Trypanosoma cruzi hypothetical protein 0.0071 0.007 1
Brugia malayi Hsp90 protein 0.0032 0.0023 0.0023
Echinococcus granulosus intermediate filament protein 0.0031 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0081 0.0081
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0008 0.1174
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0124 0.0136 0.0652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Onchocerca volvulus 0.0033 0.0024 0.1508
Loa Loa (eye worm) hypothetical protein 0.014 0.0157 0.0157
Brugia malayi hypothetical protein 0.014 0.0157 0.0157
Schistosoma mansoni peroxidasin 0.003 0.002 0.002
Onchocerca volvulus 0.003 0.002 0.1297
Mycobacterium leprae Conserved hypothetical protein 0.1306 0.1599 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trypanosoma brucei heat shock protein, putative 0.0049 0.0043 1
Treponema pallidum recombinase A 0.0124 0.0136 0.1301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0054 0.0054
Onchocerca volvulus Cell death protein 3 homolog 0.0033 0.0024 0.1508
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0079 0.0079
Onchocerca volvulus 0.0041 0.0034 0.2176
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0021 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0079 0.0079
Mycobacterium ulcerans recombinase A 0.0124 0.0136 0.2052
Loa Loa (eye worm) hypothetical protein 0.033 0.0391 0.0391
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0004 0.0004
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0135 0.015 0.015
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus multilocularis microtubule associated protein 2 0.1473 0.1805 0.1805
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Echinococcus granulosus transcription factor eb 0.0115 0.0125 0.0125
Brugia malayi Bromodomain containing protein 0.0096 0.0102 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0066 0.0066
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.009 0.0094 0.0094
Plasmodium falciparum MO15-related protein kinase 0.0362 0.0431 1
Echinococcus granulosus lamin 0.0031 0.0021 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0005 0.0005
Trichomonas vaginalis Sentrin-specific protease, putative 0.0071 0.007 0.0899
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0027 0.0342
Brugia malayi Endoplasmin precursor 0.0049 0.0043 0.0043
Echinococcus granulosus serine:threonine protein kinase haspin 0.0024 0.0013 0.0013
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Echinococcus granulosus caspase 2 0.0033 0.0024 0.0024
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0338 0.0402 1
Echinococcus multilocularis heat shock protein 90 0.0042 0.0035 0.0035
Echinococcus granulosus heat shock protein 90 0.0049 0.0043 0.0043
Schistosoma mansoni rab6-interacting 0.0023 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0079 0.0081 0.1041
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0023 0.3278
Loa Loa (eye worm) hypothetical protein 0.0053 0.0049 0.0049
Loa Loa (eye worm) beta-lactamase 0.0041 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0049 0.0043 1
Echinococcus granulosus expressed conserved protein 0.0204 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.033 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.014 0.0157 0.0157
Onchocerca volvulus 0.0041 0.0034 0.2176
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0034 0.4854
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0043 0.0553
Echinococcus multilocularis hypothetical protein 0.0024 0.0013 0.0013
Echinococcus granulosus sentrin specific protease 8 0.0071 0.007 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0014 0.0176
Schistosoma mansoni smad1 5 8 and 0.0018 0.0005 0.0005
Echinococcus granulosus endoplasmin 0.0046 0.004 0.004
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0023 0.0023
Treponema pallidum replicative DNA helicase (dnaB) 0.0443 0.0531 0.6626
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0011
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0046 0.004 0.0075
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1791 0.2198 0.2198
Brugia malayi MH2 domain containing protein 0.0018 0.0005 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0034 0.0063
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0315 0.0373 0.2166
Echinococcus multilocularis peroxidasin 0.003 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.8097 1 1
Brugia malayi hypothetical protein 0.0027 0.0016 0.0016
Schistosoma mansoni endoplasmin 0.0049 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Onchocerca volvulus Huntingtin homolog 0.014 0.0157 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Brugia malayi Animal haem peroxidase family protein 0.003 0.002 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0037 0.0037
Onchocerca volvulus Peroxidase homolog 0.003 0.002 0.1297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0063 0.1571
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0079 0.0081 0.1041
Schistosoma mansoni hypothetical protein 0.0039 0.0031 0.0031
Onchocerca volvulus 0.0041 0.0034 0.2176
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0004 0.0088
Schistosoma mansoni lamin 0.0031 0.0021 0.0021
Echinococcus granulosus muscleblind protein 0.033 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0434 0.052 0.052
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0025 0.0014 0.1954
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0046 0.004 0.9145
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0071 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0114 0.0124 0.0124
Entamoeba histolytica hypothetical protein 0.0079 0.0081 0.1041
Loa Loa (eye worm) hypothetical protein 0.0114 0.0124 0.0124
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0016 0.0375
Plasmodium falciparum heat shock protein 90, putative 0.0184 0.0211 0.4896
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0004 0.0004
Onchocerca volvulus Peroxidasin homolog 0.003 0.002 0.1297
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0019 0.0019
Echinococcus multilocularis cpg binding protein 0.0035 0.0026 0.0026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0009 0.0009
Onchocerca volvulus 0.0023 0.0011 0.0703
Trichomonas vaginalis heat shock protein, putative 0.0046 0.004 0.0506
Toxoplasma gondii heat shock protein HSP90 0.0049 0.0043 0.1076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Schistosoma mansoni smad 0.0018 0.0005 0.0005
Brugia malayi MH1 domain containing protein 0.0018 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni zinc finger protein 0.0029 0.0019 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0034 0.789
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0021
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0018 0.0418
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi Peroxidasin 0.003 0.002 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0034 0.0437
Echinococcus multilocularis muscleblind protein 1 0.033 0.0391 0.0391
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0645 0.0781 1
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0014 0.0176
Mycobacterium tuberculosis Conserved protein 0.0041 0.0034 0.0063
Schistosoma mansoni bromodomain containing protein 0.0082 0.0085 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Schistosoma mansoni peroxidasin 0.003 0.002 0.002
Brugia malayi hypothetical protein 0.003 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0021
Echinococcus granulosus cpg binding protein 0.0035 0.0026 0.0026
Echinococcus multilocularis protein patched 0.0093 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0018 0.0006 0.1367
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0071 0.007 0.0899
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.8097 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0311 0.0367 0.0367
Onchocerca volvulus 0.003 0.002 0.1297
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0014 0.0176
Echinococcus granulosus cyclin dependent kinase 9 0.0025 0.0014 0.0014
Onchocerca volvulus Huntingtin homolog 0.014 0.0157 1
Leishmania major hypothetical protein, conserved 0.0041 0.0034 0.789
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0645 0.0781 1
Echinococcus granulosus heat shock protein 90 0.0042 0.0035 0.0035
Onchocerca volvulus Peroxidase homolog 0.003 0.002 0.1297
Giardia lamblia Grp94/Hsp90 0.0046 0.004 0.0506
Brugia malayi heat shock protein 90 0.0049 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0033 0.0024 0.0024
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0009 0.0009
Echinococcus multilocularis cyclin dependent kinase 9 0.0025 0.0014 0.0014
Loa Loa (eye worm) haspin protein kinase 0.0025 0.0014 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 23.7558 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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