TDR Targets

Basic information

Technical information

TDR Targets ID: 1460791
Name: N'-[2-(3,4-dimethoxyphenyl)ethyl]-N-(4-fluoro phenyl)pyrrolidine-1,2-dicarboxamide
MW: 415.458 | Formula: C22H26FN3O4
H donors: 2 H acceptors: 2 LogP: 2.98 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(CCNC(=O)C2CCCN2C(=O)Nc2ccc(cc2)F)ccc1OC
InChi: 1S/C22H26FN3O4/c1-29-19-10-5-15(14-20(19)30-2)11-12-24-21(27)18-4-3-13-26(18)22(28)25-17-8-6-16(23)7-9-17/h5-10,14,18H,3-4,11-13H2,1-2H3,(H,24,27)(H,25,28)
InChiKey: DYXCMNPBGSOMHC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Bibliographic reference
Homo sapiens	snurportin 1	No references
Homo sapiens	karyopherin (importin) beta 1	No references
Homo sapiens	RAN, member RAS oncogene family	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0155	0.015
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0114	0.053
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0048	0.031	0.0937
Schistosoma mansoni	voltage-gated ion channel	0.004	0.0228	0.0222
Echinococcus multilocularis	hyperpolarization activated cyclic	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0114	0.1993
Trichomonas vaginalis	ran, putative	0.0026	0.0087	0.1422
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0114	0.0109
Brugia malayi	Importin beta-1 subunit	0.0035	0.0177	0.0188
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0087	0.0082
Onchocerca volvulus		0.0036	0.0186	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0077	0.059	0.0642
Toxoplasma gondii	hypothetical protein	0.004	0.0228	0.0677
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0155	0.015
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.3465	0.3794
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.059	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0238	0.2163	0.2159
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0186	0.0493
Schistosoma mansoni	hypothetical protein	0.1041	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0186	0.0198
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0087	0.7137
Schistosoma mansoni	hypothetical protein	0.007	0.0524	0.0519
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0047	0.0296	0.0893
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0168	0.0508
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0228	0.0222
Schistosoma mansoni	acetyl-CoA synthetase	0.0034	0.0168	0.0163
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0238	0.2163	0.2159
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0034	0.0168	0.1609
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0155	0.015
Brugia malayi	hypothetical protein	0.004	0.0228	0.0244
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0228	0.0222
Brugia malayi	AMP-binding enzyme family protein	0.0079	0.061	0.0663
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.004	0.0224	0.0677
Brugia malayi	Transient-receptor-potential like protein	0.004	0.0228	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0155	0.0165
Toxoplasma gondii	propionate-CoA ligase	0.0034	0.0168	0.0483
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0177	0.0172
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.004	0.0228	0.0244
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0021	0.0017
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0552	0.0547
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0186	0.0561
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0155	0.0165
Brugia malayi	Cyclic-nucleotide gated cation channel	0.004	0.0228	0.0244
Echinococcus multilocularis	sodium leak channel non selective protein	0.004	0.0228	0.0222
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0155	0.0165
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0228	0.0222
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0155	0.0165
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Mycobacterium ulcerans	hypothetical protein	0.0034	0.0168	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0168	0.0179
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.0228	0.0244
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0155	0.0165
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0155	0.0165
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0039	0.0216	0.0189
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Echinococcus multilocularis	two pore calcium channel protein 1	0.004	0.0228	0.0222
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0035	0.0175	0.017
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0034	0.0168	0.0508
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0186	0.018
Leishmania major	acetyl-CoA synthetase, putative	0.0034	0.0168	0.0447
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.059	0.1705
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0039	0.0216	0.0189
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0155	0.0165
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0114	0.0283
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0155	0.015
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.004	0.0228	0.0222
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0114	0.1751
Echinococcus multilocularis	potassium large conductance calcium activated	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Echinococcus multilocularis	zinc finger protein	0.0042	0.0245	0.024
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0155	0.015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0155	0.015
Echinococcus granulosus	voltage dependent calcium channel	0.0952	0.9125	0.9124
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0228	0.0222
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0155	0.015
Entamoeba histolytica	hypothetical protein	0.0026	0.009	0.1291
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0228	0.0222
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0019	0.0021	0.0001
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0155	0.015
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0168	0.0508
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0155	0.0165
Echinococcus granulosus	short transient receptor potential channel 6	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0164
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0228	0.0222
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.0356	0.3314	1
Schistosoma mansoni	importin beta-1	0.0035	0.0177	0.0172
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0114	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0034	0.0168	0.0441
Entamoeba histolytica	acyl-coA synthetase, putative	0.0034	0.0168	0.2773
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0155	0.0165
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0228	0.0222
Brugia malayi	voltage-dependent calcium channel	0.004	0.0228	0.0244
Entamoeba histolytica	hypothetical protein	0.0028	0.0113	0.1729
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0047	0.0296	0.0893
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0186	0.0102
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0186	0.0493
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0155	0.015
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0155	0.015
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0186	0.0561
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0228	0.0222
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0087	0.0199
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0238	0.2163	0.2366
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0228	0.0222
Echinococcus granulosus	potassium large conductance calcium activated	0.004	0.0228	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0155	0.0165
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0087	0.0218
Entamoeba histolytica	hypothetical protein	0.0073	0.0552	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0216	0.0189
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.0168	0.0179
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.004	0.0228	0.0222
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0054	0.01
Echinococcus granulosus	short transient receptor potential channel 6	0.004	0.0228	0.0222
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0036	0.0193	0.0188
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0228	0.0222
Echinococcus granulosus	hypothetical protein	0.004	0.0228	0.0222
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.004	0.0228	0.0222
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0019	0.0021	0.0016
Echinococcus granulosus	TRP transient receptor potential channel	0.004	0.0228	0.0222
Echinococcus granulosus	hyperpolarization activated cyclic	0.004	0.0228	0.0222
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0186	0.0102
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0228	0.0222
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0155	0.015
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0039	0.0216	0.0652
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0186	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0168	0.0179
Brugia malayi	ecdysteroid receptor	0.0033	0.0155	0.0165
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.004	0.0228	0.0222
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0228	0.0222
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0228	0.0222
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0048	0.031	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0168	0.0179
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.004	0.0228	0.0244
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0051	0.034	0.1026
Brugia malayi	hypothetical protein	0.005	0.0324	0.0349
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0034	0.0168	0.0052
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0034	0.0168	0.0508
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Schistosoma mansoni	ryanodine receptor related	0.004	0.0228	0.0222
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.039	0.3645	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.004	0.0228	0.0244
Entamoeba histolytica	hypothetical protein	0.0073	0.0552	1
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0114	0.0305
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0155	0.015
Loa Loa (eye worm)	hypothetical protein	0.0292	0.2682	0.2935
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.004	0.0228	0.0222
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0488	0.0483
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0637	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0952	0.9125	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.017
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.1106	0.1207
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.015
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0039	0.0216	0.0208
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.004	0.0228	0.0244
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0155	0.0165
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.015
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0186	0.0561
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0155	0.015
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0039	0.0218	0.0194
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0048	0.031	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0186	0.0198
Schistosoma mansoni	transient receptor potential channel	0.004	0.0228	0.0222
Echinococcus granulosus	GPCR family 2	0.0033	0.0155	0.015
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.004	0.0228	0.0222
Schistosoma mansoni	hypothetical protein	0.1041	1	1
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0034	0.0168	0.2773
Echinococcus multilocularis	geminin	0.1041	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0155	0.0164
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0036	0.0193	0.0188
Brugia malayi	AMP-binding enzyme family protein	0.002	0.0029	0.0026
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.004	0.0228	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0155	0.0165
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0228	0.4423
Toxoplasma gondii	FATC domain-containing protein	0.0026	0.009	0.0225
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0048	0.0307	0.0302
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0168	0.0508
Onchocerca volvulus		0.0036	0.0186	0.0362
Leishmania major	GTP-binding protein, putative	0.0026	0.0087	0.0202
Leishmania major	hypothetical protein, conserved	0.004	0.0228	0.0627
Loa Loa (eye worm)	fatty acid synthase	0.0048	0.0304	0.0328
Brugia malayi	ion channel NompC	0.004	0.0228	0.0244
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0019	0.0021	0.0016
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0087	0.009
Echinococcus multilocularis	voltage dependent calcium channel	0.0952	0.9125	0.9124
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0155	0.015
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0048	0.031	0.0507
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0034	0.0168	0.0163
Toxoplasma gondii	type I fatty acid synthase, putative	0.0056	0.0386	0.1196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.009	0.1469
Trypanosoma cruzi	ISWI complex protein	0.0033	0.0156	0.0405
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.004	0.0228	0.0222
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0034	0.0168	0.1609
Schistosoma mansoni	FFA transport protein	0.0361	0.336	0.3356
Loa Loa (eye worm)	ion channel NompC	0.004	0.0228	0.0244
Brugia malayi	steroid hormone receptor	0.0033	0.0155	0.0165
Brugia malayi	Melibiase family protein	0.0067	0.0488	0.0529
Leishmania major	hypothetical protein, conserved	0.0036	0.0186	0.05
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0034	0.0168	0.0052
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0034	0.0168	0.0483
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0128	0.1082	0.1077
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0228	0.0677
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0228	0.0222
Echinococcus multilocularis	transient receptor potential gamma protein	0.004	0.0228	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0155	0.0165
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.004	0.0228	0.0244
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0033	0.0155	0.015
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0331	0.3073	0.3363
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0228	0.0222
Mycobacterium ulcerans	thioesterase TesA	0.004	0.0232	0.0233
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.059	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0021	0.0017
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0842	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0292	0.2682	0.2935
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0113	0.1967
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.059	0.1705
Brugia malayi	MH2 domain containing protein	0.013	0.1106	0.1207
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0079	0.061	0.1842
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0155	0.015
Echinococcus granulosus	voltage gated hydrogen channel 1	0.004	0.0228	0.0222
Loa Loa (eye worm)	acyl carrier protein	0.0022	0.0055	0.0054
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0228	0.0244
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0051	0.034	0.0599
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0067	0.0488	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0186	0.0561
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0019	0.0021	0.0016
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0039	0.0218	0.0214
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.004	0.0228	0.0222
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0155	0.015
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0034	0.0168	0.0447
Entamoeba histolytica	hypothetical protein	0.0073	0.0552	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0177	0.0512
Leishmania major	fatty acid transporter protein-like protein	0.0356	0.3314	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0952	0.9125	0.9124
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0034	0.0168	0.0052
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0952	0.9125	0.9124
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0051	0.034	0.0599
Schistosoma mansoni	ran	0.0026	0.0087	0.0082
Schistosoma mansoni	bromodomain containing protein	0.0135	0.1157	0.1152
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0186	0.3527
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0048	0.031	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0102	0.0106
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Schistosoma mansoni	hypothetical protein	0.004	0.0228	0.0222
Mycobacterium leprae	Polyketide synthase Pks13	0.0072	0.0545	0.1246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0155	0.0165
Echinococcus granulosus	sodium leak channel non selective protein	0.004	0.0228	0.0222
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.004	0.0228	0.0244
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0228	0.0222
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.004	0.0228	0.0677
Echinococcus multilocularis	sodium channel protein	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Echinococcus multilocularis	ryanodine receptor 44f	0.004	0.0228	0.0222
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0029	0.0122	0.0369
Schistosoma mansoni	voltage-dependent calcium channel	0.004	0.0228	0.0222
Toxoplasma gondii	hypothetical protein	0.004	0.0228	0.0677
Echinococcus granulosus	zinc finger protein	0.0042	0.0245	0.024
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0155	0.015
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.015
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0186	0.0198
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0952	0.9125	0.9124
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0155	0.015
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0026	0.009	0.0084
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0238	0.2163	0.2159
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0039	0.0216	0.0231
Onchocerca volvulus		0.0034	0.0168	0.0155
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0186	0.0561
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0031	0.0144	0.0404
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.1106	0.1207
Leishmania major	acetyl-CoA synthetase, putative	0.0034	0.0168	0.0447
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0039	0.0216	0.0189
Echinococcus granulosus	sodium channel protein	0.004	0.0228	0.0222
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0087	0.009
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0155	0.015
Schistosoma mansoni	vesicular amine transporter	0.004	0.0228	0.0222
Toxoplasma gondii	melibiase subfamily protein	0.01	0.0813	0.2596
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0186	0.0102
Echinococcus multilocularis	transfer RNA-Gly	0.004	0.0228	0.0222
Brugia malayi	cation channel family protein	0.004	0.0228	0.0244
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0952	0.9125	0.9124
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0035	0.0175	0.017
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.004	0.0228	0.0222
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0155	0.015
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0113	0.0279
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0155	0.0165
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0036	0.0193	0.0188
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.0361	0.336	0.3356
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0048	0.031	0.0459
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0113	0.1967
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.004	0.0232	0.0257
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0034	0.0168	0.0483
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.039	0.3645	0.3991
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0155	0.015
Echinococcus granulosus	calcium activated potassium channel	0.004	0.0228	0.0222
Echinococcus granulosus	transient receptor potential gamma protein	0.004	0.0228	0.0222
Echinococcus granulosus	two pore calcium channel protein 1	0.004	0.0228	0.0222
Schistosoma mansoni	calcium-activated potassium channel	0.004	0.0228	0.0222
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0034	0.0168	0.0057
Mycobacterium ulcerans	lipase LipD	0.0036	0.0186	0.0102
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0039	0.0218	0.0194
Brugia malayi	cation channel family protein	0.004	0.0228	0.0244
Schistosoma mansoni	hypothetical protein	0.0073	0.0552	0.0547
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0039	0.0216	0.0652
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0552	0.0547
Echinococcus multilocularis	hyperpolarization activated cyclic	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0034	0.0168	0.0441
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0048	0.031	0.0335
Schistosoma mansoni	zinc finger protein	0.0033	0.0156	0.0151
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.004	0.0228	0.0222
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.004	0.0228	0.0244
Brugia malayi	hypothetical protein	0.0073	0.0552	0.06
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0019	0.0021	0.0016
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0034	0.0168	0.0052
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0034	0.0168	0.0508
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0155	0.015
Mycobacterium tuberculosis	Probable thioesterase TesA	0.004	0.0232	0.0699
Echinococcus multilocularis	two pore calcium channel protein 2	0.004	0.0228	0.0222
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0228	0.0222
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.0168	0.0179
Toxoplasma gondii	transporter, cation channel family protein	0.0331	0.3073	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0021	0.0017
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0177	0.0512
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Echinococcus multilocularis	snurportin 1	0.0372	0.3465	0.3462
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0488	0.0483
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0952	0.9125	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0177	0.0188
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0888	0.8505	0.8505
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0072	0.0545	0.1643
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.004	0.0228	0.0244
Echinococcus granulosus	voltage dependent calcium channel	0.0331	0.3073	0.3069
Echinococcus granulosus	serine protein kinase ATM	0.0026	0.009	0.0084
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0155	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0155	0.0165
Schistosoma mansoni	voltage-gated cation channel	0.0952	0.9125	0.9124
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.004	0.0228	0.0677
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0051	0.034	0.1026
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0228	0.0222
Brugia malayi	beta-lactamase	0.0036	0.0186	0.0198
Loa Loa (eye worm)	oxidoreductase	0.0034	0.0168	0.0179
Entamoeba histolytica	Ran family GTPase	0.0026	0.0087	0.125
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0228	0.0677
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.004	0.0228	0.0244
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0678	0.0738
Echinococcus multilocularis	muscleblind protein	0.0155	0.1355	0.135
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0168	0.0179
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0155	0.015
Loa Loa (eye worm)	hypothetical protein	0.0331	0.3073	0.3363
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0228	0.0222
Echinococcus granulosus	shaker cognate	0.004	0.0228	0.0222
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0155	0.015
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0186	0.0112
Schistosoma mansoni	hypothetical protein	0.0044	0.0267	0.0262
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0687	0.0747
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0186	0.018
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0114	0.0305
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0026	0.009	0.0225
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0186	0.0198
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0186	0.3527
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0361	0.336	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0488	0.0529
Echinococcus granulosus	snurportin 1	0.0372	0.3465	0.3462
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.004	0.0228	0.0619
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0186	0.0561
Schistosoma mansoni	zinc finger protein	0.0042	0.0245	0.024
Mycobacterium ulcerans	polyketide synthase	0.0051	0.034	0.0543
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0168	0.0508
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0113	0.1967
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0039	0.0216	0.0189
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0034	0.0168	0.0057
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0039	0.0216	0.0652
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0228	0.0222
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0238	0.2163	0.2159
Echinococcus multilocularis	shaker cognate	0.004	0.0228	0.0222
Loa Loa (eye worm)	voltage-gated potassium channel	0.004	0.0228	0.0244
Loa Loa (eye worm)	hypothetical protein	0.007	0.0524	0.0569
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0114	0.053
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0155	0.015
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0114	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0186	0.0198
Toxoplasma gondii	type I fatty acid synthase, putative	0.0035	0.0174	0.0502
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.1355	0.135
Echinococcus multilocularis	short transient receptor potential channel 6	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0842	0.0918
Echinococcus granulosus	long chain fatty acid transport protein 4	0.0361	0.336	0.3356
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0186	0.018
Brugia malayi	Bromodomain containing protein	0.0082	0.0636	0.0691
Onchocerca volvulus		0.0036	0.0186	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0168	0.0179
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0228	0.0222
Echinococcus multilocularis	conserved hypothetical protein	0.004	0.0228	0.0222
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0034	0.0168	0.0483
Plasmodium vivax	ataxin-2 like protein, putative	0.0077	0.059	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0186	0.0561
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0113	0.0275
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0228	0.0222
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.0168	0.0179
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0228	0.0222
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0952	0.9125	0.9124
Schistosoma mansoni	ran	0.0026	0.0087	0.0082
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.004	0.0228	0.0222
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.004	0.0228	0.0244
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0155	0.0164
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.004	0.0228	0.0244
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0051	0.034	0.0599
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0088	0.0082
Toxoplasma gondii	hypothetical protein	0.0292	0.2682	0.8721
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.004	0.0228	0.0862
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0552	0.0547
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.004	0.0228	0.0222
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0186	0.3527
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0186	0.0561
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0019	0.0021	0.0016
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0842	0.0918
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0193	0.0188
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0034	0.0168	0.0057
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0114	1
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0228	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0155	0.0165
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0034	0.0168	0.0052
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0087	0.0199
Mycobacterium ulcerans	polyketide synthase Pks13	0.0072	0.0545	0.1128
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0072	0.0545	0.1643
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.01	0.0813	0.0808
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0952	0.9125	0.9124
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.004	0.0228	0.0244
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0228	0.0222
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0186	0.054
Brugia malayi	nuclear hormone receptor	0.0033	0.0155	0.0165
Brugia malayi	beta-lactamase family protein	0.0036	0.0186	0.0198
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0034	0.0168	0.0052
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0193	0.0188
Plasmodium falciparum	importin beta, putative	0.0035	0.0177	0.1784
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.004	0.0228	0.0627
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0048	0.031	0.0937
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.0021	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0193	0.0206
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0228	0.0222
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0186	0.0198
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0039	0.0216	0.3672
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0238	0.2163	0.2366
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Schistosoma mansoni	hypothetical protein	0.0372	0.3465	0.3462
Onchocerca volvulus		0.0039	0.0216	0.0726
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0186	0.0561
Echinococcus multilocularis	calcium activated potassium channel	0.004	0.0228	0.0222
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0186	0.0102
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0155	0.015
Onchocerca volvulus	Fatty acid synthase homolog	0.0087	0.069	0.6394
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0048	0.031	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0054	0.0054
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0155	0.015
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0186	0.3527
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0186	0.3527
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0029	0.0122	0.0332
Brugia malayi	Flap endonuclease-1	0.0028	0.0114	0.0119
Leishmania major	hypothetical protein, conserved	0.0033	0.0156	0.0411
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0813	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0726	0.0791
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.002	0.0029	0.0087
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0034	0.0168	0.0052
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.004	0.0228	0.0222
Trichomonas vaginalis	esterase, putative	0.0036	0.0186	0.3527
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0034	0.0168	0.0052
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0228	0.0222
Schistosoma mansoni	hypothetical protein	0.0033	0.0156	0.0151
Toxoplasma gondii	ABC1 family protein	0.0036	0.0186	0.054
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.004	0.0228	0.0677
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0048	0.031	0.0459
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0051	0.034	0.0543
Trichomonas vaginalis	antibiotic synthetase, putative	0.0034	0.0168	0.3155
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0177	0.1784
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Schistosoma mansoni	transient receptor potential channel	0.004	0.0228	0.0222
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0048	0.0307	0.0302
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0186	0.1954
Echinococcus multilocularis	short transient receptor potential channel 6	0.004	0.0228	0.0222
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.004	0.0228	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0186	0.0198
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0155	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0155	0.0165
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0186	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1355	0.148
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.01	0.0813	0.0808
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.004	0.0228	0.0244
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0228	0.0222
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0155	0.0164
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0524	0.0569
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0193	0.0188
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0813	0.0808
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0228	0.4423
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0077	0.0586	0.0581
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Echinococcus granulosus	two pore calcium channel protein 2	0.004	0.0228	0.0222
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0087	0.0082
Trypanosoma cruzi	ISWI complex protein	0.0033	0.0156	0.0405
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0228	0.0222
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0228	0.0222
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0361	0.336	1
Onchocerca volvulus		0.0034	0.0168	0.0155
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0079	0.061	0.0663
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.004	0.0228	0.0222
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0238	0.2163	0.2159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0155	0.0165
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0155	0.015
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0331	0.3073	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0813	0.0808
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Loa Loa (eye worm)	voltage-gated potassium channel	0.004	0.0228	0.0244
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0168	0.0508
Schistosoma mansoni	transient receptor potential channel 4	0.004	0.0228	0.0222
Schistosoma mansoni	transient receptor potential channel	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0165
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0034	0.0168	0.0163
Onchocerca volvulus		0.004	0.0228	0.0862
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.0168	0.0179
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Trichomonas vaginalis	antibiotic synthetase, putative	0.0034	0.0168	0.3155
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0331	0.3073	0.9139
Entamoeba histolytica	hypothetical protein	0.0073	0.0552	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0186	0.0198
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0228	0.0222
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0128	0.1082	0.1077
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0155	0.0165
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.2063	0.6226
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0034	0.0168	0.0441
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0155	0.0165
Trypanosoma brucei	ISWI complex protein	0.0033	0.0156	0.0443
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0228	0.0222
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.0168	0.0179
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0114	0.0279
Echinococcus granulosus	fetal alzheimer antigen falz	0.0048	0.0307	0.0302
Brugia malayi	Muscleblind-like protein	0.0155	0.1355	0.148
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0034	0.0168	0.0179
Brugia malayi	AMP-binding enzyme family protein	0.039	0.3645	0.3991
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0228	0.0222
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0155	0.015
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Mycobacterium ulcerans	thioesterase	0.004	0.0232	0.0233
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0039	0.0216	0.0652
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0155	0.015
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0034	0.0168	0.0483
Schistosoma mansoni	coup transcription factor	0.0033	0.0155	0.015
Loa Loa (eye worm)	calcium channel	0.0952	0.9125	1
Echinococcus granulosus	muscleblind protein	0.0155	0.1355	0.135
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0155	0.0165
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Toxoplasma gondii	LsmAD domain-containing protein	0.0077	0.059	0.1866
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0051	0.034	0.1026
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.004	0.0228	0.0244
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0155	0.0165
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0026	0.009	0.0092
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0155	0.015
Echinococcus granulosus	hyperpolarization activated cyclic	0.004	0.0228	0.0222
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0842	0.0918
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.01	0.0813	0.0808
Schistosoma mansoni	two-pore calcium channel	0.004	0.0228	0.0222
Brugia malayi	beta-lactamase family protein	0.0036	0.0186	0.0198
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Echinococcus granulosus	ryanodine receptor 44f	0.004	0.0228	0.0222
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0952	0.9125	0.9124
Echinococcus multilocularis	serine protein kinase ATM	0.0026	0.009	0.0084
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0228	0.0222
Mycobacterium ulcerans	polyketide synthase	0.0048	0.031	0.0459
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0035	0.0177	0.0535
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0177	0.0172
Brugia malayi	hypothetical protein	0.0077	0.059	0.0642
Mycobacterium ulcerans	acyl-CoA synthetase	0.0034	0.0168	0.0052
Brugia malayi	Bromodomain containing protein	0.016	0.1401	0.153
Brugia malayi	olfactory channel protein osm-9	0.004	0.0228	0.0244
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.015
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0228	0.0222
Leishmania major	hypothetical protein, conserved	0.0077	0.059	0.1729
Loa Loa (eye worm)	voltage-gated calcium channel	0.004	0.0228	0.0244
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0155	0.0165
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0155	0.0165
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.009	0.0206
Brugia malayi	RNA, U transporter 1	0.0099	0.0804	0.0875
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0087	0.0218
Onchocerca volvulus		0.0079	0.061	0.544
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0952	0.9125	0.9124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0238	0.2163	0.2159
Leishmania major	4-coumarate:coa ligase-like protein	0.0034	0.0168	0.0447
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0813	0.0808
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0155	0.015
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0034	0.0168	0.0441
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0051	0.034	0.0543
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0186	0.0198
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0177	0.0512
Leishmania major	hypothetical protein, unknown function	0.004	0.0228	0.0627
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0019	0.0021	0.0016
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.004	0.0228	0.0244
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0028	0.0106	0.0321
Schistosoma mansoni	60S ribosomal protein L21	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Onchocerca volvulus		0.0118	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0228	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1312	0.1432
Brugia malayi	PHD-finger family protein	0.0053	0.0357	0.0385
Loa Loa (eye worm)	bromodomain containing protein	0.0038	0.0206	0.022
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0952	0.9125	0.9124
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0034	0.0168	0.2773
Loa Loa (eye worm)	PHD-finger family protein	0.0044	0.0267	0.0287
Leishmania major	4-coumarate:coa ligase-like protein	0.0034	0.0168	0.0447
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0077	0.0586	0.0581
Leishmania major	4-coumarate:coa ligase-like protein	0.0034	0.0168	0.0447
Loa Loa (eye worm)	ryanodine receptor	0.004	0.0228	0.0244
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0238	0.2163	0.2159
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0036	0.0193	0.0188
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1355	0.148
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0228	0.0222
Trypanosoma brucei	PAB1-binding protein , putative	0.0077	0.059	0.1866
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0092	0.0734	0.0799
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0186	0.018
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0034	0.0168	0.0057
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0193	0.0188
Echinococcus multilocularis	voltage dependent calcium channel	0.0952	0.9125	0.9124
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0228	0.0222
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0356	0.3314	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.2643 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1612573

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1460791