Detailed information for compound 148477

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 813.945 | Formula: C41H55N11O7
  • H donors: 9 H acceptors: 7 LogP: 0.14 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](NC1=O)Cc1c[nH]c2c1cccc2)C(=O)N
  • InChi: 1S/C41H55N11O7/c42-36(55)29-14-6-7-19-45-34(53)17-18-35(54)52-21-9-16-33(52)40(59)51-31(22-25-10-2-1-3-11-25)38(57)49-30(15-8-20-46-41(43)44)37(56)50-32(39(58)48-29)23-26-24-47-28-13-5-4-12-27(26)28/h1-5,10-13,24,29-33,47H,6-9,14-23H2,(H2,42,55)(H,45,53)(H,48,58)(H,49,57)(H,50,56)(H,51,59)(H4,43,44,46)/t29-,30+,31-,32-,33?/m0/s1
  • InChiKey: RSZGGZUMSYSTES-HSVZMYSGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0223 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.0558
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.056 0.5369 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0052 0.034 0.0758
Plasmodium vivax vivapain-2 0.0462 0.4399 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0366 0.0366
Onchocerca volvulus 0.002 0.0023 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.0896 0.1521
Plasmodium falciparum pyruvate kinase 0.0109 0.0905 0.2016
Entamoeba histolytica pyruvate kinase, putative 0.0076 0.0577 0.1267
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0462 0.4399 0.4399
Schistosoma mansoni cathepsin F (C01 family) 0.0462 0.4399 0.4399
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0108 0.0896 0.1995
Brugia malayi glutathione reductase 0.0221 0.2009 0.2009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trichomonas vaginalis chromobox protein, putative 0.008 0.061 0.1024
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0004
Schistosoma mansoni phosphoglycerate kinase 0.0094 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0462 0.4399 0.4399
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.056 0.5369 1
Echinococcus granulosus g protein coupled receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.0462 0.4399 0.4399
Loa Loa (eye worm) blistered cuticle protein 3 0.0105 0.0862 0.0862
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0027 0.0027
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0088 0.0114
Schistosoma mansoni phosphoglycerate kinase 0.0094 0.0749 0.0749
Mycobacterium tuberculosis Probable dehydrogenase 0.0504 0.4812 0.8958
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.007 0.0512 0.049
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0366 0.0366
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0294 0.2737 0.2737
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0005 0.0005
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0052 0.034 0.3603
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0108 0.0896 0.1995
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0091 0.0119
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0484 0.1085
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0033 0.0149 0.0149
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0294 0.2737 0.5079
Loa Loa (eye worm) hypothetical protein 0.0143 0.1242 0.1242
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0005 0.0005
Schistosoma mansoni neuropeptide receptor 0.0018 0.0005 0.0005
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.1169 0.2646
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0077 0.058 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0226 0.038
Echinococcus multilocularis serotonin receptor 0.0018 0.0005 0.0005
Onchocerca volvulus Cathepsin F homolog 0.0462 0.4399 0.8658
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0027 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0005 0.0005
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0088 0.0114
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0862 0.0862
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0027 0.0091 0.0156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0479 0.0458
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0005 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0467 0.0446
Brugia malayi Pre-SET motif family protein 0.0067 0.0484 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.002 0.0023 0.0023
Echinococcus granulosus calpain 0.0021 0.0027 0.0027
Giardia lamblia Cathepsin L precursor 0.0108 0.0896 0.2367
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0108 0.0896 0.1521
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.1042
Onchocerca volvulus 0.008 0.0613 0.1199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0005 0.0005
Echinococcus granulosus cysteine protease 0.0252 0.2316 0.2316
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.3093 0.5746
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0862 0.0862
Toxoplasma gondii cathepsin CPL 0.0462 0.4399 1
Echinococcus granulosus Smad4 0.0026 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0305 0.0305
Schistosoma mansoni ap endonuclease 0.0023 0.0053 0.0053
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0341 0.0341
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0862 0.0862
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Giardia lamblia Cathepsin L precursor 0.0108 0.0896 0.2367
Plasmodium vivax pyruvate kinase 2, putative 0.0056 0.0378 0.0811
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0162 0.0261
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0005 0.0005
Schistosoma mansoni opsin-like receptor 0.0018 0.0005 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0234 0.2135 0.3953
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Echinococcus granulosus microtubule associated protein 2 0.0716 0.6917 0.6917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0027 0.0091 0.0091
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0504 0.4812 0.8958
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Leishmania major phosphoglycerate kinase C, glycosomal 0.0094 0.0749 0.136
Mycobacterium ulcerans hypothetical protein 0.0174 0.1545 0.2652
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0108 0.0896 0.0896
Entamoeba histolytica hypothetical protein 0.0108 0.0896 0.1995
Onchocerca volvulus Cathepsin L homolog 0.0462 0.4399 0.8658
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.019 0.0312
Trichomonas vaginalis glutaminase, putative 0.06 0.5763 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0053 0.007
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0027 0.0091 0.0156
Mycobacterium ulcerans phosphoglycerate kinase 0.0094 0.0749 0.1266
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0005 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0077 0.058 0.1272
Toxoplasma gondii preprocathepsin c precursor, putative 0.0108 0.0896 0.2023
Brugia malayi Thioredoxin reductase 0.0221 0.2009 0.2009
Echinococcus multilocularis cathepsin b 0.1027 1 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0094 0.0749 0.0728
Brugia malayi pyruvate kinase, muscle isozyme 0.0023 0.005 0.005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0053 0.042
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0053 0.0083
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Trypanosoma brucei pyruvate kinase 1, putative 0.0109 0.0905 0.1651
Trichomonas vaginalis chromobox protein, putative 0.008 0.061 0.1024
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0261 0.0447
Echinococcus multilocularis pyruvate kinase 0.0086 0.0677 0.0677
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.3093 0.3077
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0462 0.4399 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Leishmania major DNA polymerase kappa, putative 0.0044 0.0261 0.0447
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0005 0.0005
Plasmodium falciparum serine repeat antigen 5 0.0108 0.0896 0.1995
Trypanosoma brucei proteasome subunit beta type-5, putative 0.007 0.0512 0.0915
Brugia malayi Pre-SET motif family protein 0.0466 0.4442 0.4442
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0462 0.4399 0.7624
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0413 0.0413
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.0558
Onchocerca volvulus 0.0047 0.0284 0.055
Brugia malayi Cathepsin L-like precursor 0.0462 0.4399 0.4399
Brugia malayi hypothetical protein 0.0229 0.2089 0.2089
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0034 0.0162 0.014
Loa Loa (eye worm) glutaminase 2 0.06 0.5763 0.5763
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0393 0.3711 0.6426
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0264 0.042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0341 0.0341
Giardia lamblia Cathepsin B precursor 0.0108 0.0896 0.2367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi MH1 domain containing protein 0.0026 0.008 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0462 0.4399 0.8658
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2316 0.524
Loa Loa (eye worm) pyruvate kinase 0.0023 0.005 0.005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0004
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0027 0.0027
Loa Loa (eye worm) MBCTL1 0.006 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Echinococcus granulosus sex peptide receptor 0.0018 0.0005 0.0005
Giardia lamblia Cysteine protease 0.0108 0.0896 0.2367
Leishmania major cathepsin L-like protease 0.056 0.5366 1
Onchocerca volvulus 0.0462 0.4399 0.8658
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0053 0.0053
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0462 0.4399 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0109 0.0905 0.0905
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.034 0.0595
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0108 0.0896 0.1521
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0005 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0005 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.0896 0.0896
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0094 0.0749 0.1689
Schistosoma mansoni adenoreceptor 0.0018 0.0005 0.0005
Toxoplasma gondii cathepsin CPC2 0.0108 0.0896 0.2023
Entamoeba histolytica cysteine protease, putative 0.0108 0.0896 0.1995
Plasmodium vivax unspecified product 0.0252 0.2316 0.524
Echinococcus multilocularis cysteine protease 0.0462 0.4399 0.4399
Echinococcus multilocularis cathepsin L 0.0252 0.2316 0.2316
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0005 0.0005
Schistosoma mansoni myosin xvIII 0.0018 0.0005 0.0005
Leishmania major phosphopantetheinyl transferase-like protein 0.0052 0.034 0.0595
Brugia malayi Blistered cuticle protein 3 0.0105 0.0862 0.0862
Mycobacterium tuberculosis Probable oxidoreductase 0.056 0.5369 1
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2316 0.2299
Echinococcus multilocularis cathepsin L cysteine protease 0.0462 0.4399 0.4399
Trypanosoma cruzi cysteine peptidase, putative 0.056 0.5366 0.5356
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0408 0.072
Brugia malayi cathepsin F-like cysteine proteinase 0.0143 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0077 0.058 0.097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1027 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.1042
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0341 0.0341
Toxoplasma gondii hypothetical protein 0.0053 0.0349 0.0778
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0896 0.1521
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Echinococcus granulosus pyruvate kinase 0.0056 0.0378 0.0378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0109 0.0905 0.0905
Loa Loa (eye worm) hypothetical protein 0.0035 0.0168 0.0168
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0294 0.2737 0.5079
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0108 0.0896 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0027 0.0008
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0088 0.0122
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.0023 0.0034
Leishmania major DNA polymerase eta, putative 0.0065 0.0467 0.0832
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0454 0.0454
Mycobacterium ulcerans pyruvate kinase 0.0109 0.0905 0.1537
Loa Loa (eye worm) Smad1 0.0026 0.008 0.008
Onchocerca volvulus Pyruvate kinase homolog 0.0109 0.0905 0.1774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0056 0.0378 0.0378
Trypanosoma cruzi cysteine protease, putative 0.0252 0.2316 0.2299
Leishmania major cathepsin L-like protease 0.0462 0.4399 0.819
Brugia malayi Melatonin receptor type 1A 0.0018 0.0005 0.0005
Brugia malayi G-protein coupled receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0005 0.0005
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0088 0.0114
Loa Loa (eye worm) ctsf protein 0.0462 0.4399 0.4399
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0213 0.0469
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0108 0.0896 0.1995
Loa Loa (eye worm) hypothetical protein 0.0041 0.0223 0.0223
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0077 0.058 0.1272
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.0896 0.1521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0108 0.0896 0.0896
Plasmodium vivax vivapain-1 0.0252 0.2316 0.524
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0776 0.0776
Schistosoma mansoni hypothetical protein 0.0039 0.0207 0.0207
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.1169 0.1169
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0326 0.3051 0.3051
Echinococcus granulosus glutamate synthase 0.002 0.0023 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0108 0.0896 0.0896
Brugia malayi Cathepsin L-like precursor 0.0319 0.2979 0.2979
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0108 0.0896 0.1995
Onchocerca volvulus 0.0186 0.1667 0.3276
Schistosoma mansoni cathepsin C 0.0108 0.0896 0.0896
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0504 0.4812 0.8958
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0005 0.0005
Schistosoma mansoni biogenic amine receptor 0.0018 0.0005 0.0005
Toxoplasma gondii proteasome subunit beta type, putative 0.007 0.0512 0.1148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0005 0.0005
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0005 0.0005
Schistosoma mansoni neuropeptide receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0065 0.0467 0.0467
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0005 0.0005
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.019 0.0381
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0207 0.0207
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0108 0.0896 0.0896
Loa Loa (eye worm) RNA binding protein 0.0064 0.0454 0.0454
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1027 1 1
Echinococcus multilocularis serotonin receptor 0.0018 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0108 0.0896 0.1995
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0053 0.0053
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0223 0.0223
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0109 0.0905 0.165
Echinococcus granulosus chromobox protein 1 0.008 0.061 0.061
Echinococcus granulosus fmrfamide receptor 0.0018 0.0005 0.0005
Schistosoma mansoni calpain (C02 family) 0.0021 0.0027 0.0027
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0467 0.0832
Echinococcus granulosus calpain 5 0.0021 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0143 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Trypanosoma brucei pyruvate kinase 1 0.0109 0.0905 0.1651
Echinococcus granulosus smad 0.0026 0.008 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.0558
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0413 0.0413
Echinococcus granulosus pyruvate kinase 0.0109 0.0905 0.0905
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0027 0.0091 0.019
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0005 0.0005
Plasmodium falciparum pyruvate kinase 2 0.0056 0.0378 0.0811
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0091 0.0156
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0252 0.2316 0.2316
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.056 0.5369 1
Echinococcus multilocularis dna polymerase kappa 0.0066 0.0479 0.0479
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0281 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0462 0.4399 0.7624
Mycobacterium ulcerans hypothetical protein 0.0027 0.0088 0.0114
Onchocerca volvulus 0.0462 0.4399 0.8658
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Giardia lamblia Phosphoglycerate kinase 0.0094 0.0749 0.1969
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0005 0.0005
Brugia malayi Dopamine receptor protein 1 0.0018 0.0005 0.0005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0077 0.058 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2316 0.3995
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0005 0.0005
Schistosoma mansoni biogenic amine receptor 0.0018 0.0005 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0056 0.0378 0.0378
Schistosoma mansoni cathepsin B (C01 family) 0.0108 0.0896 0.0896
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0005 0.0005
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.0023 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0484 0.0484
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0108 0.0896 0.0896
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0005 0.0005
Chlamydia trachomatis phosphoglycerate kinase 0.0094 0.0749 0.8234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis hypothetical protein 0.0021 0.0027 0.0027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.137 0.135
Plasmodium falciparum proteasome subunit beta type-5 0.007 0.0512 0.1118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0386 0.0386
Echinococcus granulosus serine:threonine protein kinase 0.0238 0.218 0.218
Leishmania major mitochondrial DNA polymerase beta 0.033 0.3093 0.5746
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0776 0.0776
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0391 0.0391
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0005 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0053 0.0053
Brugia malayi Animal haem peroxidase family protein 0.0108 0.0891 0.0891
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1027 1 1
Leishmania major pyruvate kinase 0.0109 0.0905 0.1651
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0094 0.0749 0.1266
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0484 0.0484
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0294 0.2737 0.2737
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0896 0.1521
Loa Loa (eye worm) hypothetical protein 0.0057 0.0386 0.0386
Trypanosoma cruzi trypanothione reductase, putative 0.0221 0.2009 0.1991
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0077 0.058 0.1302
Brugia malayi Peroxidasin 0.0108 0.0891 0.0891
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0776 0.0776
Echinococcus granulosus hypothetical protein 0.0018 0.0005 0.0005
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0026 0.0075 0.0099
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0027 0.0091 0.0091
Echinococcus multilocularis pyruvate kinase 0.0056 0.0378 0.0378
Mycobacterium ulcerans glutaminase 0.06 0.5763 1
Brugia malayi Proteasome A-type and B-type family protein 0.007 0.0512 0.0512
Onchocerca volvulus 0.0462 0.4399 0.8658
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0391 0.0391
Brugia malayi Smad1 0.0026 0.008 0.008
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Loa Loa (eye worm) animal heme peroxidase 0.0108 0.0891 0.0891
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0005 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0143 0.1242 0.1242
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0023 0.0023
Schistosoma mansoni sulfide quinone reductase 0.002 0.0023 0.0023
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.1169 0.1169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.008 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0275 0.2541 0.2541
Trypanosoma brucei phosphoglycerate kinase, putative 0.0034 0.0162 0.0261
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0005 0.0005
Echinococcus granulosus g protein coupled receptor 0.0018 0.0005 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.0896 0.0896
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0023 0.0023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0077 0.058 0.097
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0143 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Plasmodium falciparum phosphoglycerate kinase 0.0094 0.0749 0.166
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0005 0.0005
Echinococcus granulosus traf and tnf receptor associated protein 0.0193 0.1735 0.1735
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.0056 0.0378 0.0378
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0341 0.0341
Plasmodium falciparum serine repeat antigen 9 0.0108 0.0896 0.1995
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0294 0.2737 0.2737
Plasmodium vivax vivapain-3 0.0252 0.2316 0.524
Onchocerca volvulus Huntingtin homolog 0.0275 0.2541 0.4998
Onchocerca volvulus 0.0052 0.0341 0.0664
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0479 0.0458
Plasmodium falciparum serine repeat antigen 1 0.0108 0.0896 0.1995
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0005 0.0005
Giardia lamblia Pyruvate kinase 0.0109 0.0905 0.2392
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0023 0.0034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.019 0.019
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0077 0.058 0.1042
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0264 0.051
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0023 0.0023
Mycobacterium ulcerans proteasome PrcB 0.007 0.0512 0.0852
Echinococcus granulosus cathepsin b 0.1027 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2089 0.2089
Echinococcus granulosus CTD small phosphatase protein like 0.0027 0.0091 0.0091
Trypanosoma brucei cysteine peptidase C (CPC) 0.0393 0.3711 0.6903
Loa Loa (eye worm) cathepsin B 0.0393 0.3711 0.3711
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0108 0.0896 0.1995
Leishmania major cathepsin L-like protease 0.0462 0.4399 0.819
Schistosoma mansoni Smad4 0.0026 0.008 0.008
Brugia malayi Pyruvate kinase, muscle isozyme 0.0109 0.0905 0.0905
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0462 0.4399 0.4399
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0454 0.0454
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0479 0.0458
Giardia lamblia Cathepsin B precursor 0.0108 0.0896 0.2367
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0454 0.0454
Onchocerca volvulus Pyruvate kinase homolog 0.0109 0.0905 0.1774
Echinococcus granulosus cathepsin b 0.1027 1 1
Plasmodium falciparum serine repeat antigen 2 0.0108 0.0896 0.1995
Brugia malayi polk-prov protein 0.0041 0.0226 0.0226
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.3093 0.3077
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0108 0.0896 0.1995
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0862 0.0862
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0504 0.4812 0.8958
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0027 0.0008
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0052 0.034 0.0726
Plasmodium vivax glutathione reductase, putative 0.0221 0.2009 0.4539
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0052 0.034 0.0554
Giardia lamblia Cathepsin L precursor 0.0108 0.0896 0.2367
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0479 0.0458
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0018 0.0005 0.0005
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0091 0.0119
Plasmodium falciparum thioredoxin reductase 0.0221 0.2009 0.4539
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0186 0.1667 0.1667
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0108 0.0896 0.0896
Trichomonas vaginalis pyruvate kinase, putative 0.0109 0.0905 0.1537
Trypanosoma brucei phosphoglycerate kinase 0.0094 0.0749 0.136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0005 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0005 0.0005
Schistosoma mansoni peroxidasin 0.0105 0.0862 0.0862
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0454 0.0454
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Giardia lamblia Cathepsin L precursor 0.0108 0.0896 0.2367
Plasmodium vivax proteasome subunit beta type-5, putative 0.007 0.0512 0.1118
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0005 0.0005
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0108 0.0896 0.1995
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.1169 0.1169
Toxoplasma gondii thioredoxin reductase 0.0221 0.2009 0.4558
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0147 0.0233
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0005 0.0005
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.007 0.0512 0.1118
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.0896 0.0896
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0484 0.0484
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0052 0.034 0.0726
Echinococcus granulosus neuropeptide receptor 0.0018 0.0005 0.0005
Echinococcus granulosus g protein coupled receptor 0.0018 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0077 0.058 0.7666
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0005 0.0005
Brugia malayi mbt repeat family protein 0.0052 0.0341 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0226 0.038
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0052 0.034 0.4376
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1545 0.2847
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.007 0.0512 0.0512
Plasmodium falciparum serine repeat antigen 4 0.0108 0.0896 0.1995
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0252 0.2316 0.2316
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0319 0.2979 0.2979
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0005 0.0005
Loa Loa (eye worm) pyruvate kinase 0.0109 0.0905 0.0905
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0391 0.0391
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0479 0.0855
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0091
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0005 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0005 0.0005
Loa Loa (eye worm) pyruvate kinase-PB 0.0076 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis somatostatin receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Echinococcus multilocularis geminin 0.0537 0.5143 0.5143
Loa Loa (eye worm) hypothetical protein 0.0108 0.0896 0.0896
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.0558
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.1169 0.2145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0108 0.0896 0.1995
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0147 0.0233
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0108 0.0896 0.1995
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.019 0.019
Echinococcus granulosus calpain A 0.0021 0.0027 0.0027
Brugia malayi hypothetical protein 0.0105 0.0862 0.0862
Trypanosoma cruzi pyruvate kinase 2, putative 0.0109 0.0905 0.0884
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0462 0.4399 0.4399
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0052 0.034 0.0758
Plasmodium vivax phosphoglycerate kinase, putative 0.0094 0.0749 0.166
Brugia malayi Cathepsin L-like precursor 0.0143 0.1242 0.1242
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.2135 0.2117
Loa Loa (eye worm) hypothetical protein 0.0052 0.0341 0.0341
Echinococcus multilocularis pyruvate kinase 0.0109 0.0905 0.0905
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0862 0.0862
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0004
Echinococcus multilocularis chromobox protein 1 0.008 0.061 0.061
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0252 0.2316 0.2299
Loa Loa (eye worm) hypothetical protein 0.0041 0.0226 0.0226
Onchocerca volvulus Pyruvate kinase homolog 0.0109 0.0905 0.1774
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0294 0.2737 0.6202
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.4399 0.4386
Echinococcus multilocularis pyruvate kinase 0.0056 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0076 0.0577 0.0577
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0005 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.0896 0.0896
Echinococcus granulosus proteasome prosome macropain 0.007 0.0512 0.0512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.0558
Entamoeba histolytica cysteine protease, putative 0.0108 0.0896 0.1995
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0077 0.058 0.1042
Giardia lamblia Cathepsin B precursor 0.0393 0.3711 1
Giardia lamblia Hypothetical protein 0.0108 0.0896 0.2367
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0297 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2316 0.3995
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0005 0.0005
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0108 0.0896 0.1995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.008 0.008
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0479 0.0796
Loa Loa (eye worm) hypothetical protein 0.0045 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0143 0.1242 0.1222
Toxoplasma gondii selenide, water dikinase 0.002 0.0023 0.0034
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.6917 0.6917
Trichomonas vaginalis mercuric reductase, putative 0.0077 0.058 0.097
Brugia malayi cathepsin L-like cysteine proteinase 0.0108 0.0896 0.0896
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0108 0.0896 0.1995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0108 0.0896 0.1521
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0108 0.0896 0.1995
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.0896 0.1521
Loa Loa (eye worm) calpain 0.0021 0.0027 0.0027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0281 0.0259
Echinococcus granulosus orexin receptor type 2 0.0018 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.056 0.5366 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0027 0.0091 0.0128
Echinococcus granulosus dna polymerase kappa 0.0066 0.0479 0.0479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0206 0.1863 0.1845
Mycobacterium tuberculosis Conserved protein 0.0027 0.0088 0.0122
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Schistosoma mansoni hypothetical protein 0.0047 0.0284 0.0284
Plasmodium falciparum serine repeat antigen 8 0.0108 0.0896 0.1995
Leishmania major DNA polymerase eta, putative 0.004 0.0213 0.0357
Echinococcus granulosus pyruvate kinase 0.0056 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Onchocerca volvulus 0.0531 0.508 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1242 0.1242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0034 0.0161 0.0308
Leishmania major pyruvate kinase 0.0109 0.0905 0.1651
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0005 0.0005
Giardia lamblia Cysteine protease 0.0108 0.0896 0.2367
Echinococcus multilocularis traf and tnf receptor associated protein 0.0193 0.1735 0.1735
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0091 0.0091
Giardia lamblia NADH oxidase lateral transfer candidate 0.0077 0.058 0.151
Echinococcus granulosus allatostatin A receptor 0.0018 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0454 0.0454
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0053 0.0053
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0052 0.034 0.0726
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) cysteine protease 0.0462 0.4399 0.4399
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2316 0.524
Brugia malayi G protein-coupled receptor 0.0018 0.0005 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0484 0.0484
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0504 0.4812 0.8958
Brugia malayi putative neuropeptide receptor 0.0018 0.0005 0.0005
Schistosoma mansoni survival motor neuron protein 0.0047 0.0284 0.0284
Schistosoma mansoni histamine h1 receptor 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Plasmodium vivax unspecified product 0.0143 0.1242 0.2785
Brugia malayi Dopamine receptor 0.0018 0.0005 0.0005
Trypanosoma brucei phosphoglycerate kinase 0.0034 0.0162 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2316 0.4292
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0108 0.0896 0.0896
Brugia malayi MH2 domain containing protein 0.0026 0.008 0.008
Echinococcus granulosus thioredoxin glutathione reductase 0.0222 0.2025 0.2025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.1939 0.1939
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis chromobox protein 1 0.008 0.061 0.061
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0005 0.0005
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0391 0.0391
Brugia malayi sulfakinin receptor protein 0.0018 0.0005 0.0005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0053 0.042
Trypanosoma cruzi cysteine proteinase, putative 0.0252 0.2316 0.2299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Trichomonas vaginalis pyruvate kinase, putative 0.0109 0.0905 0.1537
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Schistosoma mansoni biogenic amine receptor 0.0018 0.0005 0.0005
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0005 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.1169 0.1998
Trypanosoma cruzi cysteine proteinase, putative 0.0252 0.2316 0.2299
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0297 0.0576
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0108 0.0896 0.2367
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0005 0.0005
Echinococcus multilocularis calpain 0.0021 0.0027 0.0027
Schistosoma mansoni opsin-like receptor 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi neuropeptide F receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi RE15519p 0.0018 0.0005 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.0896 0.0896
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0776 0.0776
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0776 0.0776
Entamoeba histolytica cysteine protease, putative 0.0108 0.0896 0.1995
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0108 0.0896 0.1521
Loa Loa (eye worm) transcription factor SMAD2 0.0383 0.3619 0.3619
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0094 0.0749 0.1689
Echinococcus granulosus serotonin receptor 0.0018 0.0005 0.0005
Giardia lamblia Hypothetical protein 0.0108 0.0896 0.2367
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0053 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0462 0.4399 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.007 0.0512 0.0852
Plasmodium vivax vivapain-2 0.0462 0.4399 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0008
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0091 0.0119
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0005 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0386 0.0386
Plasmodium falciparum cysteine proteinase falcipain 1 0.0252 0.2316 0.524
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Trichomonas vaginalis dullard protein, putative 0.0027 0.0091 0.0119
Schistosoma mansoni smad1 5 8 and 0.0026 0.008 0.008
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0053 0.0057
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Loa Loa (eye worm) pyruvate kinase 0.0109 0.0905 0.0905
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0466 0.4442 0.4442
Echinococcus granulosus cathepsin L cysteine proteinase 0.0462 0.4399 0.4399
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0005 0.0005
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0896 0.1521
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0027 0.0027
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.019 0.019
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0393 0.3711 0.6903
Entamoeba histolytica phosphoglycerate kinase, putative 0.0094 0.0749 0.166
Brugia malayi calpain family protein 1 0.0055 0.0366 0.0366
Leishmania major trypanothione reductase 0.0221 0.2009 0.3718
Plasmodium vivax pyruvate kinase, putative 0.0109 0.0905 0.2016
Plasmodium falciparum serine repeat antigen 7 0.0108 0.0896 0.1995
Brugia malayi TAR-binding protein 0.0064 0.0454 0.0454
Brugia malayi Cathepsin L-like precursor 0.0462 0.4399 0.4399
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0462 0.4399 1
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0005 0.0005
Echinococcus granulosus tar DNA binding protein 0.0064 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0039 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni chromobox protein 0.008 0.061 0.061
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2316 0.524
Leishmania major cathepsin L-like protease 0.0462 0.4399 0.819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0294 0.2737 0.2737
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0504 0.4812 0.8958
Echinococcus granulosus neuropeptide receptor 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0462 0.4399 1
Giardia lamblia Cathepsin L-like protease 0.0108 0.0896 0.2367
Echinococcus multilocularis cathepsin b 0.1027 1 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0896 0.0896
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0094 0.0749 0.1359
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.1169 0.1998
Brugia malayi Serotonin receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.056 0.5366 0.5356
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0027 0.0027
Entamoeba histolytica cysteine proteinase 1, putative 0.0252 0.2316 0.524
Leishmania major cysteine peptidase A (CPA) 0.0462 0.4399 0.819
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0094 0.0749 0.1266
Echinococcus granulosus cathepsin l1 0.0319 0.2979 0.2979
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0023 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0053 0.0053
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0077 0.058 0.1042
Plasmodium falciparum cysteine proteinase falcipain 3 0.0462 0.4399 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0077 0.058 0.058
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0005 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.1169 0.2146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0393 0.3711 0.3697
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0467 0.0467
Brugia malayi hypothetical protein 0.0275 0.2541 0.2541
Brugia malayi G-protein coupled receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0162 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Brugia malayi Heterochromatin protein 1 0.008 0.061 0.061
Loa Loa (eye worm) thioredoxin reductase 0.0221 0.2009 0.2009
Loa Loa (eye worm) hypothetical protein 0.0229 0.2089 0.2089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0018 0.0005 0.0005
Onchocerca volvulus Peroxidasin homolog 0.0108 0.0891 0.1746
Onchocerca volvulus Cathepsin L homolog 0.0108 0.0896 0.1756
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0023 0.0023
Schistosoma mansoni neuropeptide receptor 0.0018 0.0005 0.0005
Brugia malayi cathepsin L precursor 0.0108 0.0896 0.0896
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0077 0.058 0.097
Plasmodium falciparum glutathione reductase 0.0077 0.058 0.1272
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0294 0.2737 0.272
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0077 0.058 0.058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.046 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0135 0.0195
Echinococcus granulosus cathepsin l cysteine peptidase 0.0462 0.4399 0.4399
Brugia malayi Papain family cysteine protease containing protein 0.0252 0.2316 0.2316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0896 0.1521
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0023 0.0023
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Loa Loa (eye worm) hypothetical protein 0.006 0.0413 0.0413
Echinococcus granulosus pyruvate kinase 0.0109 0.0905 0.0905
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.2979 0.515
Schistosoma mansoni smad1 5 8 and 0.0026 0.008 0.008
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0023 0.0023
Echinococcus multilocularis smad 0.0026 0.008 0.008
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0088 0.0122
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0005 0.0005
Trypanosoma brucei trypanothione reductase 0.0221 0.2009 0.3718
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0005 0.0005
Giardia lamblia Cysteine protease 0.0108 0.0896 0.2367
Echinococcus multilocularis calpain 5 0.0021 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0005 0.0005
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0862 0.0862
Brugia malayi MH1 domain containing protein 0.0026 0.008 0.008
Giardia lamblia Encystation-specific protease 0.0108 0.0896 0.2367
Echinococcus granulosus dna polymerase eta 0.0065 0.0467 0.0467
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0088 0.0065
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0053 0.0053
Brugia malayi Cathepsin L-like precursor 0.0462 0.4399 0.4399
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0281 0.0259
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0091 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Onchocerca volvulus Peroxidase homolog 0.0105 0.0862 0.1689
Trichomonas vaginalis DNA polymerase eta, putative 0.0066 0.0479 0.0796
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis glutamate synthase 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.1939 0.1939
Mycobacterium tuberculosis Probable reductase 0.0504 0.4812 0.8958
Schistosoma mansoni smad1 5 8 and 0.0026 0.008 0.008
Echinococcus multilocularis dna polymerase eta 0.0065 0.0467 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0261 0.0447
Mycobacterium leprae Probable pyruvate kinase PykA 0.0109 0.0905 0.165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.0109 0.0905 0.0905
Echinococcus multilocularis Smad4 0.0026 0.008 0.008
Toxoplasma gondii cathepsin B 0.0393 0.3711 0.8434
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0186 0.1667 0.1667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0108 0.0896 0.1756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2316 0.524
Onchocerca volvulus 0.0462 0.4399 0.8658
Schistosoma mansoni glutaminase 0.06 0.5763 0.5763
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0147 0.0233
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Trypanosoma cruzi cruzipain precursor, putative 0.0143 0.1242 0.1222
Treponema pallidum NADH oxidase 0.0077 0.058 0.7666
Trypanosoma cruzi cruzipain precursor, putative 0.056 0.5366 0.5356
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0077 0.058 0.1272
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0027 0.0091 0.0128
Entamoeba histolytica cysteine proteinase, putative 0.0319 0.2979 0.6755
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.019 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0108 0.0896 0.0896
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0135 0.0195
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0094 0.0749 0.0728
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.019 0.019
Echinococcus granulosus cathepsin l1 0.0462 0.4399 0.4399
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.6917 0.6917
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.0275 0.2541 0.4998
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0005 0.0005
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0108 0.0896 0.2367
Echinococcus granulosus somatostatin receptor 0.0018 0.0005 0.0005
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi larval opioid receptor 0.0018 0.0005 0.0005
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0005 0.0005
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis cysteine protease 0.0462 0.4399 0.4399
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0091 0.0069
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0213 0.0191
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0108 0.0896 0.1995
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0023 0.0034
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0264 0.042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0077 0.058 0.7666
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0053 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0005 0.0005
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.007 0.0512 0.0915
Entamoeba histolytica cysteine protease, putative 0.0108 0.0896 0.1995
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0382 0.036
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0297 0.0478
Schistosoma mansoni glutamate synthase 0.002 0.0023 0.0023
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0091 0.0156
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0053 0.0057
Schistosoma mansoni pyruvate kinase 0.0056 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0108 0.0896 0.2367
Schistosoma mansoni pyruvate kinase 0.0109 0.0905 0.0905
Giardia lamblia Cathepsin B precursor 0.0108 0.0896 0.2367
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0052 0.034 0.0554
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0108 0.0896 0.2367
Plasmodium vivax unspecified product 0.0108 0.0896 0.1995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Giardia lamblia Cathepsin B precursor 0.0108 0.0896 0.2367
Brugia malayi fibroinase precursor 0.0108 0.0896 0.0896
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni chromobox protein 0.008 0.061 0.061
Brugia malayi neuropeptide F receptor 0.0018 0.0005 0.0005
Echinococcus granulosus chromobox protein 1 0.008 0.061 0.061
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0193 0.1735 0.1735
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0005 0.0005
Brugia malayi Phosphoglycerate kinase 0.0094 0.0749 0.0749
Schistosoma mansoni smad 0.0026 0.008 0.008
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0023 0.0023
Echinococcus granulosus cathepsin L cysteine protease 0.0252 0.2316 0.2316
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.061 0.061
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Schistosoma mansoni hypothetical protein 0.0537 0.5143 0.5143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0393 0.3711 0.3711
Plasmodium falciparum serine repeat antigen 6 0.0108 0.0896 0.1995
Entamoeba histolytica cysteine protease, putative 0.0108 0.0896 0.1995
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0108 0.0896 0.1521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0896 0.1521
Brugia malayi Cathepsin L-like precursor 0.0462 0.4399 0.4399
Entamoeba histolytica cysteine proteinase 2 0.0252 0.2316 0.524
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0341 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0183 0.1639 0.3715
Brugia malayi pyruvate kinase 0.0023 0.005 0.005
Echinococcus granulosus geminin 0.0537 0.5143 0.5143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Brugia malayi Papain family cysteine protease containing protein 0.0462 0.4399 0.4399
Giardia lamblia Pyruvate kinase 0.0056 0.0378 0.0962
Leishmania major cathepsin L-like protease 0.0462 0.4399 0.819
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0077 0.058 0.6312
Schistosoma mansoni hypothetical protein 0.0027 0.0088 0.0088
Giardia lamblia Cathepsin B precursor 0.0108 0.0896 0.2367
Brugia malayi glutamate synthase 0.002 0.0023 0.0023
Toxoplasma gondii pyruvate kinase PyK1 0.0109 0.0905 0.2043
Brugia malayi Cathepsin L-like precursor 0.0462 0.4399 0.4399
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0108 0.0896 0.1995
Schistosoma mansoni cathepsin s 0.0143 0.1242 0.1242
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0035 0.0168 0.0322
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.137 0.2521
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0108 0.0896 0.1995
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.058 0.0558
Onchocerca volvulus 0.0462 0.4399 0.8658
Brugia malayi mbt repeat family protein 0.0052 0.0341 0.0341
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0416 0.3946 0.3932
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2316 0.4292
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0896 0.1521
Mycobacterium leprae conserved hypothetical protein 0.0052 0.034 0.0595
Brugia malayi AKH receptor 0.0018 0.0005 0.0005
Echinococcus granulosus transcription factor Dp 1 0.017 0.1509 0.1509
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.008 0.008
Schistosoma mansoni opsin-like receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Brugia malayi glutaminase DH11.1 0.06 0.5763 0.5763
Leishmania major cathepsin L-like protease 0.056 0.5366 1
Onchocerca volvulus Peroxidase homolog 0.0105 0.0862 0.1689
Loa Loa (eye worm) hypothetical protein 0.0319 0.2979 0.2979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Echinococcus multilocularis serine:threonine protein kinase 0.0238 0.218 0.218
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0221 0.2009 0.4539
Giardia lamblia Cysteine protease 0.0108 0.0896 0.2367
Loa Loa (eye worm) hypothetical protein 0.0186 0.1667 0.1667
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0281 0.0484
Giardia lamblia Cathepsin B precursor 0.0393 0.3711 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0108 0.0896 0.0896
Mycobacterium leprae proteasome (beta subunit) PrcB 0.007 0.0512 0.0915
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1027 1 1
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0023 0.0023
Trypanosoma brucei antigen, putative 0.0021 0.0027 0.0008
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0238 0.218 0.218
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0366 0.0366
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0053 0.0053
Plasmodium vivax calpain, putative 0.0021 0.0027 0.001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0238 0.218 0.218
Loa Loa (eye worm) programmed cell death 8 0.002 0.0023 0.0023
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0091 0.0119
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0023 0.0023
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0413 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0383 0.3619 0.3619
Treponema pallidum phosphoglycerate kinase 0.0094 0.0749 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0052 0.034 0.0595
Loa Loa (eye worm) hypothetical protein 0.0067 0.0484 0.0484
Echinococcus multilocularis phosphoglycerate kinase 1 0.0094 0.0749 0.0749
Trypanosoma cruzi pyruvate kinase 2, putative 0.0109 0.0905 0.0884
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0005 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.0896 0.0896
Brugia malayi calpain 7 0.0021 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0275 0.2541 0.2541
Echinococcus granulosus peroxidasin 0.0108 0.0891 0.0891
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0053 0.0031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0222 0.2025 0.2025
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0862 0.0862
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0077 0.058 0.0558
Schistosoma mansoni sulfide quinone reductase 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0294 0.2737 0.272
Schistosoma mansoni glutamate synthase 0.002 0.0023 0.0023
Echinococcus granulosus L aminoadipate semialdehyde 0.0186 0.1667 0.1667
Onchocerca volvulus Chorion peroxidase homolog 0.0105 0.0862 0.1689
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0027 0.0004
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0088 0.0088
Plasmodium falciparum glutathione reductase 0.0221 0.2009 0.4539
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.008 0.0613 0.0613
Giardia lamblia DINP protein human, muc B family 0.0044 0.0261 0.0648
Trypanosoma cruzi cysteine peptidase, putative 0.056 0.5366 0.5356
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.058 0.0558
Brugia malayi Cathepsin L-like cysteine proteinase 0.0319 0.2979 0.2979
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0005 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.1169 0.1998
Loa Loa (eye worm) fibroinase 0.0462 0.4399 0.4399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0776 0.0776
Brugia malayi ORL1-like opioid receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0234 0.2135 0.3953
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0221 0.2009 0.3716
Brugia malayi cathepsin Z-like cysteine proteinase 0.0108 0.0896 0.0896
Brugia malayi hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0479 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.2979 0.515
Loa Loa (eye worm) hypothetical protein 0.1027 1 1
Giardia lamblia Cathepsin L-like protease 0.0108 0.0896 0.2367
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0454 0.0454
Mycobacterium ulcerans hypothetical protein 0.0027 0.0088 0.0114
Trypanosoma brucei unspecified product 0.0059 0.0408 0.072
Trypanosoma cruzi major cysteine proteinase, putative 0.0108 0.0896 0.0875
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0462 0.4399 0.4399
Plasmodium vivax serine-repeat antigen (SERA) 0.0108 0.0896 0.1995
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.1169 0.1169
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Plasmodium falciparum thioredoxin reductase 0.0077 0.058 0.1272
Loa Loa (eye worm) hypothetical protein 0.0108 0.0896 0.0896
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0479 0.0796
Toxoplasma gondii NADPH-glutathione reductase 0.0077 0.058 0.1302
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0108 0.0896 0.1521
Brugia malayi RNA binding protein 0.0064 0.0454 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.056 0.5366 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0341 0.0341
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0005 0.0005
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.0462 0.4399 0.819
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0094 0.0749 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0108 0.0896 0.0896
Echinococcus multilocularis peroxidasin 0.0108 0.0891 0.0891
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0034 0.0162 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.0896 0.1521
Onchocerca volvulus 0.0105 0.0862 0.1689
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.0896 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Trichomonas vaginalis glutathione reductase, putative 0.0077 0.058 0.097
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.019 0.019
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.007 0.0512 0.049
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.0896 0.0896
Giardia lamblia Proteasome subunit beta type 5 precursor 0.007 0.0512 0.1326
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0027 0.0008
Brugia malayi calpain family protein 1 0.0055 0.0366 0.0366
Trypanosoma brucei phosphoglycerate kinase 0.0094 0.0749 0.136
Onchocerca volvulus 0.0105 0.0862 0.1689
Loa Loa (eye worm) pyruvate kinase 0.0109 0.0905 0.0905
Echinococcus granulosus pyruvate kinase 0.0056 0.0378 0.0378
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0004
Plasmodium vivax serine-repeat antigen (SERA) 0.0108 0.0896 0.1995
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0053 0.0057
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0294 0.2737 0.2737
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2089 0.2089
Onchocerca volvulus Dual oxidase homolog 0.0105 0.0862 0.1689
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0077 0.058 0.1042
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0023 0.0023
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0034 0.0162 0.014
Echinococcus granulosus cathepsin L 0.0252 0.2316 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0454 0.0454
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.007 0.0512 0.0512
Schistosoma mansoni amine GPCR 0.0018 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0484 0.0484
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0077 0.058 0.1272
Loa Loa (eye worm) glutaminase 0.06 0.5763 0.5763
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0077 0.058 0.0558
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0088
Schistosoma mansoni neuropeptide receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Giardia lamblia Cathepsin L precursor 0.0108 0.0896 0.2367
Schistosoma mansoni pyruvate kinase 0.0109 0.0905 0.0905
Echinococcus multilocularis sex peptide receptor 0.0018 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0005 0.0005
Trichomonas vaginalis dullard protein, putative 0.0027 0.0091 0.0119
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0162 0.014
Brugia malayi chromobox protein homolog 3 0.0045 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0896 0.1521
Trypanosoma brucei unspecified product 0.0026 0.0075 0.0099
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.008 0.008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1027 1 1
Brugia malayi MH2 domain containing protein 0.0026 0.008 0.008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0005 0.0005
Brugia malayi MH2 domain containing protein 0.0383 0.3619 0.3619
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0252 0.2316 0.2316
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.2135 0.2117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0066 0.0479 0.0796
Echinococcus multilocularis calpain A 0.0058 0.0391 0.0391
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0005 0.0005
Schistosoma mansoni DNA polymerase eta 0.0065 0.0467 0.0467
Onchocerca volvulus Peroxidasin homolog 0.0108 0.0891 0.1746
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0004
Trichomonas vaginalis dullard protein, putative 0.0027 0.0091 0.0119
Onchocerca volvulus 0.0319 0.2979 0.586
Brugia malayi Serotonin receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis proteasome (prosome, macropain) 0.007 0.0512 0.0512
Plasmodium vivax SET domain protein, putative 0.0067 0.0484 0.1054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0284 0.0284
Leishmania major phosphoglycerate kinase B, cytosolic 0.0094 0.0749 0.136
Toxoplasma gondii pyruvate kinase PyKII 0.0056 0.0378 0.0842
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0776 0.0776
Echinococcus granulosus calpain A 0.0058 0.0391 0.0391
Echinococcus multilocularis cathepsin L cysteine protease 0.0462 0.4399 0.4399
Brugia malayi Cathepsin L-like precursor 0.0319 0.2979 0.2979
Onchocerca volvulus 0.0105 0.0862 0.1689
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0161
Brugia malayi Phosphoglycerate kinase 0.0034 0.0162 0.0162
Brugia malayi Papain family cysteine protease containing protein 0.0252 0.2316 0.2316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0077 0.058 0.1042
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0094 0.0749 0.1359
Trichomonas vaginalis set domain proteins, putative 0.0531 0.508 0.881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.4399 0.7624
Plasmodium falciparum serine repeat antigen 3 0.0108 0.0896 0.1995
Onchocerca volvulus 0.0462 0.4399 0.8658
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0261 0.0447
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0005 0.0005
Giardia lamblia Cathepsin B precursor 0.0393 0.3711 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0862 0.0862
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.008 0.008
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0341 0.0341
Entamoeba histolytica cysteine protease, putative 0.0252 0.2316 0.524
Echinococcus multilocularis transcription factor Dp 1 0.017 0.1509 0.1509
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0108 0.0896 0.1521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0776 0.0776
Giardia lamblia Cathepsin L precursor 0.0108 0.0896 0.2367
Echinococcus granulosus cathepsin L 0.0108 0.0896 0.0896
Schistosoma mansoni ap endonuclease 0.0023 0.0053 0.0053
Schistosoma mansoni amine GPCR 0.0018 0.0005 0.0005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0077 0.058 0.1042
Loa Loa (eye worm) hypothetical protein 0.0319 0.2979 0.2979
Brugia malayi cathepsin L-like precursor 0.0319 0.2979 0.2979
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0088 0.0114
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0108 0.0896 0.0896
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0108 0.0896 0.0896
Toxoplasma gondii exonuclease III APE 0.0023 0.0053 0.0104
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0896 0.1521
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis 0.0027 0.0091 0.0091
Toxoplasma gondii cathepsin CPC1 0.0108 0.0896 0.2023
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0027 0.0091 0.0091
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0462 0.4399 0.4399
Leishmania major proteasome beta 5 subunit, putative 0.007 0.0512 0.0915
Schistosoma mansoni hypothetical protein 0.0537 0.5143 0.5143
Loa Loa (eye worm) glutathione reductase 0.0221 0.2009 0.2009
Onchocerca volvulus Cathepsin L homolog 0.0462 0.4399 0.8658
Echinococcus multilocularis cathepsin L 0.0108 0.0896 0.0896
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0462 0.4399 0.7624
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0008
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0027 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0319 0.2979 0.2979
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0005 0.0005
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0027 0.0091 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0479 0.0855
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0077 0.058 0.1042
Schistosoma mansoni glutamate synthase 0.002 0.0023 0.0023
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0052 0.034 0.4376
Loa Loa (eye worm) hypothetical protein 0.0108 0.0891 0.0891
Schistosoma mansoni amine GPCR 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0094 0.0749 0.0749
Echinococcus granulosus phosphoglycerate kinase 1 0.0094 0.0749 0.0749
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0005 0.0005
Brugia malayi GnHR receptor homolog 0.0018 0.0005 0.0005
Schistosoma mansoni peroxidasin 0.0105 0.0862 0.0862
Schistosoma mansoni cathepsin S (C01 family) 0.0108 0.0896 0.0896
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0386 0.0386
Chlamydia trachomatis pyruvate kinase 0.0109 0.0905 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.137 0.2521
Echinococcus multilocularis L aminoadipate semialdehyde 0.0186 0.1667 0.1667
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0413 0.0413
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0023 0.0023
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0088 0.0065
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0341 0.0664
Brugia malayi Dopamine receptor protein 2 0.0018 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0053 0.007

Activities

Activity type Activity value Assay description Source Reference
ACT (functional) = 21 % Stimulation of intracellular cAMP levels in CHO cells expressing human Melanocortin-3 receptor ChEMBL. 12036373
ACT (functional) = 60.5 % Stimulation of intracellular cAMP levels in CHO cells expressing human Melanocortin-4 receptor ChEMBL. 12036373
ACT (functional) = 100 % Stimulation of intracellular cAMP levels in CHO cells expressing human melanocortin 5 receptor ChEMBL. 12036373
EC50 (binding) = 790 nM Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells ChEMBL. 12036373
EC50 (binding) = 1300 nM Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells ChEMBL. 12036373
EC50 (binding) = 2300 nM Inhibition of binding to human Melanocortin-4 receptor (hMC4R) ChEMBL. 12036373
Ki (binding) = 190 nM Binding affinity for human Melanocortin-4 receptor (hMC4R) ChEMBL. 12036373
Ki (binding) = 390 nM Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells ChEMBL. 12036373
Ki (binding) = 990 nM Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells ChEMBL. 12036373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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