TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.393 | Formula: C21H19N3O4
H donors: 5 H acceptors: 4 LogP: 1.57 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)[C@H]([C@H](O)C)NC(=O)c1ccc(cc1)C#CC#Cc1cccc(c1)N
InChi: 1S/C21H19N3O4/c1-14(25)19(21(27)24-28)23-20(26)17-11-9-15(10-12-17)5-2-3-6-16-7-4-8-18(22)13-16/h4,7-14,19,25,28H,22H2,1H3,(H,23,26)(H,24,27)/t14-,19+/m1/s1
InChiKey: QUFKKFVHFGSEHV-KUHUBIRLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0077	0.0073	0.0081
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Loa Loa (eye worm)	sema domain-containing protein	0.0391	0.0689	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0689	0.0684
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/DDR protein kinase	0.0059	0.0039	0.0033
Trypanosoma cruzi	PH domain containing protein, putative	0.0077	0.0073	0.4631
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0059	0.0039	0.004
Toxoplasma gondii	hypothetical protein	0.0077	0.0073	0.4631
Schistosoma mansoni	dynamin	0.0077	0.0073	0.0061
Echinococcus multilocularis	regulator of G protein signaling 3	0.0834	0.1557	0.1856
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4311	0.8366	0.8365
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0082	0.0069
Brugia malayi	hypothetical protein	0.0059	0.0039	0.0033
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0834	0.1557	0.1546
Echinococcus multilocularis	regulator of G protein signaling 7	0.0834	0.1557	0.1856
Echinococcus multilocularis	regulator of G protein signaling 3	0.0834	0.1557	0.1856
Schistosoma mansoni	protein kinase	0.0079	0.0079	0.0066
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0081	0.0082	0.5775
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0077	0.0073	0.0081
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.1557	1
Onchocerca volvulus		0.0077	0.0073	0.0206
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0077	0.0073	0.0061
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0059	0.0039	0.004
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.3109	0.6014	0.7186
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0059	0.0039	0.004
Leishmania major	hypothetical protein, conserved	0.0077	0.0073	0.4631
Loa Loa (eye worm)	hypothetical protein	0.012	0.0158	0.0152
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0077	0.0073	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0077	0.0073	0.0229
Schistosoma mansoni	dynamin	0.0077	0.0073	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Toxoplasma gondii	AtPH1 family protein	0.0077	0.0073	0.4631
Echinococcus granulosus	epidermal growth factor receptor	0.0059	0.0039	0.004
Toxoplasma gondii	hypothetical protein	0.0077	0.0073	0.4631
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Loa Loa (eye worm)	PH domain-containing protein	0.0077	0.0073	0.0068
Toxoplasma gondii	Oxysterol-binding protein	0.0077	0.0073	0.4631
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0097	0.0114	0.0494
Brugia malayi	Sema domain containing protein	0.0391	0.0689	0.0684
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0059	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0059	0.0039	0.004
Echinococcus multilocularis	activated cdc42 kinase 1	0.0059	0.0039	0.004
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0079	0.5369
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0077	0.0073	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	RGS-3 protein	0.0834	0.1557	0.1553
Echinococcus granulosus	GRB2 associated binding protein 3	0.0077	0.0073	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0059	0.0039	0.0033
Brugia malayi	Raf kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Schistosoma mansoni	protein kinase	0.0079	0.0079	0.0066
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	PH domain containing protein	0.0077	0.0073	0.0229
Entamoeba histolytica	PH domain containing protein	0.0077	0.0073	0.0229
Echinococcus multilocularis	protein kinase	0.0059	0.0039	0.004
Schistosoma mansoni	serine/threonine protein kinase	0.3944	0.7647	0.7644
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Guanylyl cyclase protein 23	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0689	0.0684
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus multilocularis	tyrosine protein kinase	0.0059	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Brugia malayi	Probable exocyst complex component Sec5	0.0171	0.0259	0.0254
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0059	0.0039	0.0248
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0077	0.0073	0.4631
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Protein kinase domain containing protein	0.031	0.0531	0.0526
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0259	0.0254
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0097	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1557	0.1553
Schistosoma mansoni	regulator of G protein signaling	0.0834	0.1557	0.1546
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0059	0.0039	0.0033
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.1557	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0114	0.0148	0.017
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus granulosus	Pleckstrin y	0.0077	0.0073	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	hypothetical protein	0.0171	0.0259	0.0246
Echinococcus granulosus	Oxysterol binding protein 11	0.0077	0.0073	0.0081
Schistosoma mansoni	syntrophin	0.0077	0.0073	0.0061
Schistosoma mansoni	hypothetical protein	0.0077	0.0073	0.0061
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0097	0.0114	0.0108
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.0073	0.4631
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.0039	0.0026
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0039	0.004
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0097	0.0114	0.073
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Echinococcus granulosus	pdz domain containing protein	0.0077	0.0073	0.0081
Echinococcus granulosus	calcium dependent secretion activator 1	0.0077	0.0073	0.0081
Leishmania major	protein kinase, putative	0.0097	0.0114	1
Loa Loa (eye worm)	Plekhf2 protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.1557	1
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Schistosoma mansoni	oxysterol-binding protein 1	0.0077	0.0073	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0039	0.0026
Brugia malayi	hypothetical protein	0.0391	0.0689	0.0684
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0097	0.0114	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0059	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Onchocerca volvulus	outspread protein homolog	0.0077	0.0073	0.0206
Entamoeba histolytica	hypothetical protein	0.0097	0.0114	0.0494
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Brugia malayi	Fibronectin type III domain containing protein	0.012	0.0158	0.0152
Echinococcus granulosus	Regulator of G protein signaling 20	0.0834	0.1557	0.1856
Plasmodium vivax	PH domain containing protein	0.0077	0.0073	0.4631
Echinococcus multilocularis	protein tyrosine kinase	0.0059	0.0039	0.004
Trichomonas vaginalis	centaurin beta, putative	0.0077	0.0073	0.0471
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0059	0.0039	0.004
Echinococcus multilocularis	c src tyrosine kinase	0.0059	0.0039	0.004
Echinococcus granulosus	activated cdc42 kinase 1	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0077	0.0073	0.4631
Echinococcus granulosus	oxysterol binding protein 3	0.0077	0.0073	0.0081
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus granulosus	semaphorin 1A	0.0391	0.0689	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	centaurin gamma, putative	0.0077	0.0073	0.0471
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0077	0.0073	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0921	0.1728	0.1724
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	hypothetical protein	0.0077	0.0073	0.0229
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	hypothetical protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0097	0.0114	1
Leishmania major	protein kinase, putative	0.0097	0.0114	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0059	0.0039	0.0033
Brugia malayi	Furin-like cysteine rich region family protein	0.0059	0.0039	0.0033
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0097	0.0114	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	epidermal growth factor receptor	0.0059	0.0039	0.004
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0097	0.0114	0.0494
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0077	0.0073	0.0081
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0171	0.0259	0.1662
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	ephrin receptor	0.0064	0.0049	0.0036
Echinococcus multilocularis	exocyst complex component 2	0.0171	0.0259	0.0303
Echinococcus granulosus	defective proboscis extension response	0.0114	0.0148	0.017
Brugia malayi	Protein kinase domain containing protein	0.0097	0.0114	0.0108
Loa Loa (eye worm)	TK/Met protein kinase	0.0059	0.0039	0.0033
Brugia malayi	regulator of G-protein signaling egl-10	0.0834	0.1557	0.1553
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0097	0.0114	1
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Schistosoma mansoni	goodpasture antigen-binding protein	0.0077	0.0073	0.0061
Entamoeba histolytica	protein kinase, putative	0.0081	0.0082	0.0285
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0097	0.0114	1
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0081	0.0082	0.0285
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Entamoeba histolytica	tyrosin kinase, putative	0.023	0.0374	0.2208
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	activin receptor type	0.0079	0.0079	0.0088
Schistosoma mansoni	tyrosine protein kinase	0.0059	0.0039	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0357	0.0352
Loa Loa (eye worm)	TK/ACK protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0097	0.0114	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Brugia malayi	Syntrophin-1	0.0077	0.0073	0.0068
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0077	0.0073	0.0081
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0077	0.0073	0.4631
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Plasmodium falciparum	PH domain-containing protein, putative	0.0077	0.0073	0.4631
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0077	0.0073	0.0081
Schistosoma mansoni	hypothetical protein	0.0171	0.0259	0.0246
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0059	0.0039	0.004
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0082	0.0077
Brugia malayi	hypothetical protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	actin binding protein anillin	0.0077	0.0073	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0689	0.0684
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0834	0.1557	0.1553
Schistosoma mansoni	hypothetical protein	0.0059	0.0039	0.0026
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0077	0.0073	0.0471
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0082	0.0077
Echinococcus granulosus	transcription factor collier	0.0171	0.0259	0.0303
Onchocerca volvulus		0.0077	0.0073	0.0206
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0097	0.0114	0.0494
Brugia malayi	ephrin receptor 1 precursor	0.0059	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Entamoeba histolytica	hypothetical protein	0.0077	0.0073	0.0229
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0097	0.0114	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0148	0.0142
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	neuroglian	0.0114	0.0148	0.017
Schistosoma mansoni	hypothetical protein	0.0077	0.0073	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	regulator of G-protein signaling rgs-7	0.0834	0.1557	0.1553
Schistosoma mansoni	growth factor receptor-bound protein	0.0077	0.0073	0.0061
Echinococcus multilocularis	epidermal growth factor receptor	0.0059	0.0039	0.004
Echinococcus multilocularis	oxysterol binding protein 9	0.0077	0.0073	0.0081
Loa Loa (eye worm)	TK/ROR protein kinase	0.0059	0.0039	0.0033
Trypanosoma cruzi	NIMA-related kinase, putative	0.0097	0.0114	1
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Brugia malayi	Cadps2 protein	0.0077	0.0073	0.0068
Onchocerca volvulus	Putative zinc finger protein	0.0077	0.0073	0.0206
Brugia malayi	Sema domain containing protein	0.0391	0.0689	0.0684
Schistosoma mansoni	hypothetical protein	0.0077	0.0073	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0077	0.0073	0.0471
Echinococcus multilocularis	Oxysterol binding protein 11	0.0077	0.0073	0.0081
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0059	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	hypothetical protein	0.0834	0.1557	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0059	0.0039	0.004
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0148	0.0142
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0079	0.0079	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0114	0.0148	0.017
Brugia malayi	C-terminal src kinase protein 1	0.0059	0.0039	0.0033
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0039	0.0248
Schistosoma mansoni	hypothetical protein	0.0077	0.0073	0.0061
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0171	0.0259	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	heat shock protein 70	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	hypothetical protein	0.0391	0.0689	0.0684
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Echinococcus granulosus	exocyst complex component 2	0.0171	0.0259	0.0303
Echinococcus multilocularis	expressed protein	0.0834	0.1557	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Onchocerca volvulus		0.0391	0.0689	0.3847
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Entamoeba histolytica	hypothetical protein	0.0171	0.0259	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1557	0.1553
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0834	0.1557	0.1856
Echinococcus multilocularis	myotubularin protein 13	0.0077	0.0073	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0059	0.0039	0.004
Echinococcus multilocularis	integrin linked protein kinase	0.0059	0.0039	0.004
Brugia malayi	Cytohesin 3	0.0077	0.0073	0.0068
Brugia malayi	serine/threonine-protein kinase 6	0.0081	0.0082	0.0077
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0059	0.0039	0.004
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0834	0.1557	0.1546
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1557	0.1553
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0077	0.0073	0.0081
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0059	0.0039	0.0248
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Schistosoma mansoni	protein kinase	0.0079	0.0079	0.0066
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0097	0.0114	1
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trypanosoma brucei	protein kinase, putative	0.0079	0.0079	0.5369
Schistosoma mansoni	hypothetical protein	0.0391	0.0689	0.0677
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0077	0.0073	0.0081
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	Pleckstrin y	0.0077	0.0073	0.0081
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0059	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Trichomonas vaginalis	centaurin/arf, putative	0.0077	0.0073	0.0471
Schistosoma mansoni	hypothetical protein	0.0077	0.0073	0.0061
Echinococcus granulosus	Pleckstrin y	0.0077	0.0073	0.0081
Onchocerca volvulus		0.0077	0.0073	0.0206
Entamoeba histolytica	p21-activated kinase	0.0097	0.0114	0.0494
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0077	0.0073	0.4631
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Brugia malayi	Pleckstrin Homology Domain	0.0077	0.0073	0.0068
Onchocerca volvulus		0.0077	0.0073	0.0206
Echinococcus multilocularis	Immunoglobulin	0.0114	0.0148	0.017
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0097	0.0114	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0077	0.0073	0.0061
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0059	0.0039	0.004
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0097	0.0114	1
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0077	0.0073	0.0068
Entamoeba histolytica	protein kinase domain containing protein	0.0081	0.0082	0.0285
Echinococcus multilocularis	neuroglian	0.0114	0.0148	0.017
Echinococcus granulosus	tyrosine kinase	0.0059	0.0039	0.004
Trypanosoma brucei	PH domain containing protein, putative	0.0077	0.0073	0.4631
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0081	0.0082	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0531	0.0963	0.0958
Loa Loa (eye worm)	TK/CSK protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0059	0.0039	0.004
Echinococcus granulosus	myotubularin protein 13	0.0077	0.0073	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	transcription factor collier	0.0171	0.0259	0.0303
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Echinococcus granulosus	cytohesin 1	0.0077	0.0073	0.0081
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0834	0.1557	0.1546
Echinococcus granulosus	integrin linked protein kinase	0.0059	0.0039	0.004
Echinococcus granulosus	activated cdc42 kinase 1	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.1557	1
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0081	0.0082	0.0092
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0097	0.0114	1
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Echinococcus granulosus	kinase suppressor of Ras 1	0.0059	0.0039	0.004
Echinococcus multilocularis	oxysterol binding protein 3	0.0077	0.0073	0.0081
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Brugia malayi	Plekhf2 protein	0.0077	0.0073	0.0068
Schistosoma mansoni	regulator of G protein signaling	0.0834	0.1557	0.1546
Schistosoma mansoni	vesicular amine transporter	0.0117	0.0153	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	protein kinase	0.0081	0.0082	0.0069
Echinococcus granulosus	pleckstrin y domain containing family A	0.0077	0.0073	0.0081
Echinococcus granulosus	roundabout 2	0.012	0.0158	0.0182
Brugia malayi	Oxysterol binding protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	regulator of G protein signaling 7	0.0834	0.1557	0.1856
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0077	0.0073	0.0081
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0077	0.0073	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/FAK protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Schistosoma mansoni	nephrin	0.012	0.0158	0.0145
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0059	0.0039	0.004
Giardia lamblia	Aurora kinase	0.0081	0.0082	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0039	0.004
Trypanosoma cruzi	aurora B kinase, putative	0.0081	0.0082	0.5775
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus granulosus	regulator of G protein signaling 7	0.0834	0.1557	0.1856
Brugia malayi	Tyrosine-protein kinase abl-1	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0077	0.0073	0.0229
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0077	0.0073	0.0471
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0059	0.0039	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.3944	0.7647	0.7644
Echinococcus granulosus	tyrosine protein kinase shark	0.0059	0.0039	0.004
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0059	0.0039	0.0033
Echinococcus multilocularis	pdz domain containing protein	0.0077	0.0073	0.0081
Entamoeba histolytica	hypothetical protein	0.0171	0.0259	0.1449
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0077	0.0073	0.0229
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0077	0.0073	0.0081
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	STE family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trypanosoma brucei	aurora B kinase	0.0081	0.0082	0.5775
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0148	0.0142
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Uncoordinated protein 104	0.0077	0.0073	0.0068
Loa Loa (eye worm)	TK/ABL protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/INSR protein kinase	0.0059	0.0039	0.0033
Echinococcus granulosus	twitchin	0.0135	0.0188	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Oxysterol-binding protein	0.0077	0.0073	0.0068
Trypanosoma cruzi	NIMA-related kinase, putative	0.0097	0.0114	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0173	0.0263	0.0258
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0059	0.0039	0.004
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0077	0.0073	0.0081
Schistosoma mansoni	serine/threonine RGC	0.0059	0.0039	0.0026
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0059	0.0039	0.0033
Brugia malayi	SH2 domain containing protein	0.0059	0.0039	0.0033
Onchocerca volvulus		0.0921	0.1728	1
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0082	0.0526
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0039	0.0026
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0059	0.0039	0.004
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0077	0.0073	0.0081
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0834	0.1557	0.1856
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0077	0.0073	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0059	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0082	0.0526
Entamoeba histolytica	hypothetical protein, conserved	0.0077	0.0073	0.0229
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0148	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0059	0.0039	0.0033
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0079	0.0079	0.5369
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus granulosus	Rho GTPase activating protein 24	0.0077	0.0073	0.0081
Loa Loa (eye worm)	SRC-1	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	beta 1 syntrophin	0.0077	0.0073	0.0081
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Echinococcus multilocularis	tyrosine protein kinase shark	0.0059	0.0039	0.004
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0059	0.0039	0.0033
Entamoeba histolytica	hypothetical protein	0.0077	0.0073	0.0229
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	beta 1 syntrophin	0.0077	0.0073	0.0081
Loa Loa (eye worm)	syntrophin-1	0.0077	0.0073	0.0068
Echinococcus granulosus	raf serine:threonine protein kinase	0.0059	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0079	0.5369
Brugia malayi	serine/threonine protein kinase 6	0.0081	0.0082	0.0077
Trichomonas vaginalis	protein transport protein sec7, putative	0.0077	0.0073	0.0471
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Schistosoma mansoni	zinc finger protein	0.0077	0.0073	0.0061
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0059	0.0039	0.004
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0097	0.0114	0.0494
Brugia malayi	Variant SH3 domain containing protein	0.0077	0.0073	0.0068
Onchocerca volvulus	Protein melted homolog	0.0077	0.0073	0.0206
Loa Loa (eye worm)	serine/threonine protein kinase	0.0059	0.0039	0.0033
Echinococcus multilocularis	regulator of G protein signaling	0.0834	0.1557	0.1856
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0834	0.1557	0.1553
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0077	0.0073	0.0081
Entamoeba histolytica	cell surface protease gp63, putative	0.0171	0.0259	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0689	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0689	0.0684
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0059	0.0039	0.004
Entamoeba histolytica	hypothetical protein	0.0171	0.0259	0.1449
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0077	0.0073	0.0229
Echinococcus granulosus	tyrosine kinase	0.0059	0.0039	0.004
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	protein transport protein sec7, putative	0.0077	0.0073	0.0471
Entamoeba histolytica	hypothetical protein	0.0834	0.1557	1
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	transfer RNA-Thr	0.0059	0.0039	0.004
Trichomonas vaginalis	kinesin light chain, putative	0.0077	0.0073	0.0471
Schistosoma mansoni	centaurin alpha	0.0077	0.0073	0.0061
Schistosoma mansoni	goodpasture antigen-binding protein	0.0077	0.0073	0.0061
Schistosoma mansoni	axis inhibition protein axin	0.0834	0.1557	0.1546
Brugia malayi	hypothetical protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4311	0.8366	1
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0834	0.1557	0.1856
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Entamoeba histolytica	protein kinase , putative	0.0081	0.0082	0.0285
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0082	0.0077
Onchocerca volvulus		0.0077	0.0073	0.0206
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Brugia malayi	Receptor family ligand binding region containing protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	plexin A	0.1093	0.2064	0.2059
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0097	0.0114	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0077	0.0073	0.0471
Echinococcus granulosus	serine/threonine protein kinase	0.0097	0.0114	0.0129
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus granulosus	tyrosine kinase	0.0059	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Brugia malayi	integrin-linked kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	plexin A	0.1093	0.2064	0.2059
Trypanosoma cruzi	PH domain containing protein, putative	0.0077	0.0073	0.4631
Brugia malayi	PH domain containing protein	0.0077	0.0073	0.0068
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0059	0.0039	0.004
Echinococcus granulosus	regulator of G protein signaling 3	0.0834	0.1557	0.1856
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0082	0.0526
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Brugia malayi	Plexin repeat family protein	0.0921	0.1728	0.1724
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Brugia malayi	Dynamin	0.0077	0.0073	0.0068
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0081	0.0082	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	oxysterol binding protein 1	0.0077	0.0073	0.0081
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0039	0.0033
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0079	0.0079	0.0088
Loa Loa (eye worm)	rho-GTPase-activating	0.0077	0.0073	0.0068
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Schistosoma mansoni	ephrin receptor	0.0059	0.0039	0.0026
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0171	0.0259	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/ALK protein kinase	0.031	0.0531	0.0526
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Leishmania major	folate/biopterin transporter, putative	0.0097	0.0114	1
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0077	0.0073	0.0081
Schistosoma mansoni	fibrocystin l	0.0171	0.0259	0.0246
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0077	0.0073	0.4631
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	oxysterol binding protein	0.0077	0.0073	0.0068
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0059	0.0039	0.0026
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0097	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0148	0.0142
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0097	0.0114	1
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.1557	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0077	0.0073	0.4631
Echinococcus multilocularis	Immunoglobulin	0.0114	0.0148	0.017
Loa Loa (eye worm)	PXA domain-containing protein	0.0834	0.1557	0.1553
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	hypothetical protein	0.0834	0.1557	0.1553
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	regulator of G protein signaling	0.0834	0.1557	0.1546
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0039	0.0026
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3944	0.7647	0.7646
Schistosoma mansoni	plexin	0.0921	0.1728	0.1718
Schistosoma mansoni	semaphorin 5-related	0.0391	0.0689	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Schistosoma mansoni	hypothetical protein	0.0391	0.0689	0.0677
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0059	0.0039	0.0248
Brugia malayi	Dynamin	0.0077	0.0073	0.0068
Onchocerca volvulus		0.0077	0.0073	0.0206
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0171	0.0259	0.1662
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0173	0.0263	0.0258
Brugia malayi	PXA domain containing protein	0.0834	0.1557	0.1553
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0079	0.0079	0.0088
Echinococcus granulosus	oxysterol binding protein 1	0.0077	0.0073	0.0081
Trypanosoma brucei	protein kinase, putative	0.0097	0.0114	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Entamoeba histolytica	hypothetical protein	0.0097	0.0114	0.0494
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0097	0.0114	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0079	0.5369
Brugia malayi	A-kinase anchor protein 10, precursor	0.0834	0.1557	0.1553
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0039	0.0033
Echinococcus multilocularis	insulin receptor	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0059	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Brugia malayi	PXA domain containing protein	0.0834	0.1557	0.1553
Trichomonas vaginalis	protein kinase atn1, putative	0.0059	0.0039	0.0248
Schistosoma mansoni	serine/threonine-protein kinase	0.0097	0.0114	0.0101
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Schistosoma mansoni	oxysterol-binding protein 1	0.0077	0.0073	0.0061
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0834	0.1557	0.1553
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4311	0.8366	0.8365
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	dynamin 1	0.0077	0.0073	0.0081
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0059	0.0039	0.004
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0077	0.0073	0.0471
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Toxoplasma gondii	protein kinase domain-containing protein	0.0097	0.0114	1
Trichomonas vaginalis	alpha chimerin, putative	0.0077	0.0073	0.0471
Loa Loa (eye worm)	hypothetical protein	0.012	0.0158	0.0152
Brugia malayi	MAX-1A	0.0077	0.0073	0.0068
Echinococcus multilocularis	axis inhibition protein axin	0.0834	0.1557	0.1856
Brugia malayi	SRC-1	0.0059	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0259	0.0254
Leishmania major	protein kinase, putative	0.0081	0.0082	0.5775
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	aurora kinase A	0.0081	0.0082	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus granulosus	oxysterol binding protein 9	0.0077	0.0073	0.0081
Trypanosoma cruzi	Protein kinase B	0.0097	0.0114	1
Brugia malayi	serine/threonine kinase 12	0.0081	0.0082	0.0077
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0097	0.0114	0.0494
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0171	0.0259	0.1662
Echinococcus multilocularis	tyrosine kinase	0.0059	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	myotubularin-related protein	0.0077	0.0073	0.0061
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0077	0.0073	0.4631
Entamoeba histolytica	hypothetical protein	0.0077	0.0073	0.0229
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0039	0.004
Echinococcus multilocularis	protein kinase	0.0059	0.0039	0.004
Echinococcus multilocularis	axis inhibition protein axin	0.0834	0.1557	0.1856
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	aurora kinase A	0.0081	0.0082	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus granulosus	protein kinase	0.0059	0.0039	0.004
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0059	0.0039	0.004
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3944	0.7647	0.914
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0082	0.0526
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	hypothetical protein	0.0531	0.0963	0.0951
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0077	0.0073	0.0068
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4311	0.8366	1
Schistosoma mansoni	protein tyrosine kinase	0.0059	0.0039	0.0026
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0077	0.0073	0.4631
Plasmodium falciparum	oxysterol-binding protein, putative	0.0077	0.0073	0.4631
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0059	0.0039	0.0033
Echinococcus granulosus	ephrin type A receptor 4 A	0.0059	0.0039	0.004
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0097	0.0114	1
Echinococcus multilocularis	cytohesin 1	0.0077	0.0073	0.0081
Echinococcus granulosus	dynamin 1	0.0077	0.0073	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0039	0.0248
Echinococcus granulosus	Pleckstrin y	0.0077	0.0073	0.0081
Echinococcus granulosus	plexin a4	0.1093	0.2064	0.2462
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0039	0.004
Schistosoma mansoni	cell adhesion molecule	0.012	0.0158	0.0145
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0059	0.0039	0.0026
Echinococcus granulosus	tyrosine protein kinase HCK	0.0059	0.0039	0.004
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Echinococcus granulosus	receptor type guanylyl cyclase	0.0059	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0834	0.1557	1
Echinococcus multilocularis	roundabout 2	0.012	0.0158	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1557	0.1553
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0059	0.0039	0.0033
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0077	0.0073	0.0081
Echinococcus granulosus	Immunoglobulin	0.0114	0.0148	0.017
Entamoeba histolytica	PH domain containing protein	0.0077	0.0073	0.0229
Trichomonas vaginalis	centaurin/arf, putative	0.0077	0.0073	0.0471
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0077	0.0073	0.4631
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0097	0.0114	1
Trypanosoma cruzi	PH domain containing protein, putative	0.0077	0.0073	0.4631
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0114	0.0148	0.0135
Echinococcus granulosus	DCC interacting protein 13 beta	0.0077	0.0073	0.0081
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0077	0.0073	0.0081
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0077	0.0073	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1557	0.1553
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Loa Loa (eye worm)	sema domain-containing protein	0.0391	0.0689	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1557	0.1553
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Echinococcus granulosus	G protein coupled receptor kinase 1	0.3109	0.6014	0.7186
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0077	0.0073	0.0206
Toxoplasma gondii	aurora kinase	0.0081	0.0082	0.5775
Schistosoma mansoni	regulator of G protein signaling	0.0834	0.1557	0.1546
Echinococcus granulosus	c src tyrosine kinase	0.0059	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0077	0.0073	0.0081
Entamoeba histolytica	hypothetical protein	0.0171	0.0259	0.1449
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Entamoeba histolytica	protein kinase, putative	0.0081	0.0082	0.0285
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0077	0.0073	0.0081
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Brugia malayi	hypothetical protein	0.012	0.0158	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0689	0.0684
Echinococcus granulosus	insulin receptor	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	hypothetical protein	0.0391	0.0689	0.0817
Echinococcus granulosus	regulator of G protein signaling 7	0.0834	0.1557	0.1856
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0259	0.0254
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0097	0.0114	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0059	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Echinococcus multilocularis	Pleckstrin y	0.0077	0.0073	0.0081
Leishmania major	serine/threonine-protein kinase a, putative	0.0097	0.0114	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	serine/threonine-protein kinase	0.0097	0.0114	0.0101
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0059	0.0039	0.0033
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0114	0.0148	0.0135
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0059	0.0039	0.0248
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Schistosoma mansoni	plexin	0.0531	0.0963	0.0951
Echinococcus granulosus	tyrosine protein kinase Srms	0.0059	0.0039	0.004
Entamoeba histolytica	protein kinase domain containing protein	0.023	0.0374	0.2208
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0059	0.0039	0.0033
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0081	0.0082	0.5775
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0059	0.0039	0.004
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0064	0.0049	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Echinococcus granulosus	tyrosine protein kinase pr2	0.0059	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0077	0.0073	0.0229
Echinococcus granulosus	tyrosine protein kinase Blk	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus multilocularis	Pleckstrin y	0.0077	0.0073	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0259	0.0254
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0059	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Echinococcus multilocularis	plexin a4	0.1093	0.2064	0.2462
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0064	0.0049	0.0052
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0059	0.0039	0.004
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Trypanosoma cruzi	PH domain containing protein, putative	0.0077	0.0073	0.4631
Entamoeba histolytica	protein kinase, putative	0.0097	0.0114	0.0494
Trichomonas vaginalis	TK family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0039	0.004
Brugia malayi	SH2 domain containing protein	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0077	0.0073	0.0068
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	hypothetical protein	0.012	0.0158	0.0152
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0059	0.0039	0.004
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Leishmania major	hypothetical protein, conserved	0.0077	0.0073	0.4631
Schistosoma mansoni	protein kinase	0.0059	0.0039	0.0026
Plasmodium falciparum	protein kinase, putative	0.0079	0.0079	0.5369
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0039	0.0033
Entamoeba histolytica	protein kinase domain containing protein	0.0079	0.0079	0.0265
Echinococcus granulosus	expressed protein	0.0834	0.1557	0.1856
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0059	0.0039	0.0026
Echinococcus granulosus	regulator of G protein signaling 3	0.0834	0.1557	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0059	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0077	0.0073	0.0061
Schistosoma mansoni	rho gtpase activating protein	0.0077	0.0073	0.0061
Echinococcus granulosus	protein tyrosine kinase	0.0059	0.0039	0.004
Echinococcus granulosus	epidermal growth factor receptor	0.0059	0.0039	0.004
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0059	0.0039	0.004
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0059	0.0039	0.004
Echinococcus granulosus	axis inhibition protein axin	0.0834	0.1557	0.1856
Entamoeba histolytica	hypothetical protein	0.0834	0.1557	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0059	0.0039	0.0033
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0081	0.0082	0.0285
Echinococcus multilocularis	rac serine:threonine kinase	0.0097	0.0114	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0148	0.0142
Trichomonas vaginalis	centaurin alpha, putative	0.0077	0.0073	0.0471
Echinococcus granulosus	semaphorin 5B	0.0391	0.0689	0.0817
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0077	0.0073	0.0061
Loa Loa (eye worm)	uncoordinated protein 104	0.0077	0.0073	0.0068
Schistosoma mansoni	tyrosine kinase	0.0059	0.0039	0.0026
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0097	0.0114	0.073
Brugia malayi	Immunoglobulin I-set domain containing protein	0.012	0.0158	0.0152
Echinococcus multilocularis	FL cytokine receptor	0.0059	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0059	0.0039	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Brugia malayi	Variant SH3 domain containing protein	0.0077	0.0073	0.0068
Entamoeba histolytica	hypothetical protein	0.0077	0.0073	0.0229
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0077	0.0073	0.0068
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4311	0.8366	0.8365
Trichomonas vaginalis	AGC family protein kinase	0.0097	0.0114	0.073
Schistosoma mansoni	vav2	0.0077	0.0073	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0039	0.0033
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3944	0.7647	0.914
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0059	0.0039	0.0033
Brugia malayi	DNA-binding protein LAG-1	0.0171	0.0259	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Brugia malayi	protein-tyrosine kinase	0.0059	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0059	0.0039	0.004
Brugia malayi	probable spectrin beta chain	0.0077	0.0073	0.0068
Echinococcus granulosus	tyrosine protein kinase	0.0059	0.0039	0.004
Onchocerca volvulus		0.0077	0.0073	0.0206
Brugia malayi	IPT/TIG domain containing protein	0.0171	0.0259	0.0254
Loa Loa (eye worm)	cytohesin 3	0.0077	0.0073	0.0068
Schistosoma mansoni	z-protein (S1r protein)	0.0834	0.1557	0.1546
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0059	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0073	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0039	0.0248
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0059	0.0039	0.004
Trypanosoma cruzi	hypothetical protein	0.0077	0.0073	0.4631
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0039	0.004
Brugia malayi	TBC domain containing protein	0.0077	0.0073	0.0068
Brugia malayi	hypothetical protein	0.0834	0.1557	0.1553
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0097	0.0114	1
Echinococcus granulosus	axis inhibition protein axin	0.0834	0.1557	0.1856
Brugia malayi	Tyrosine-protein kinase PR2	0.0059	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0259	0.1662
Echinococcus granulosus	activin receptor type	0.0079	0.0079	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.1557	1
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0077	0.0073	0.0081
Schistosoma mansoni	regulator of G protein signaling	0.0834	0.1557	0.1546
Leishmania major	protein kinase, putative	0.0079	0.0079	0.5369
Echinococcus multilocularis	semaphorin 5B	0.0391	0.0689	0.0817
Schistosoma mansoni	axis inhibition protein axin	0.0834	0.1557	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0077	0.0073	0.4631
Trichomonas vaginalis	hypothetical protein	0.0077	0.0073	0.0471
Echinococcus granulosus	natriuretic peptide receptor 1	0.0059	0.0039	0.004
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.0039	0.0026
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0039	0.0033
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0077	0.0073	0.0081
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0077	0.0073	0.0229
Schistosoma mansoni	zinc finger protein	0.0077	0.0073	0.0061
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0077	0.0073	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0073	0.0068
Echinococcus multilocularis	tyrosine kinase	0.0059	0.0039	0.004

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.06 ug ml-1	Antibacterial activity against Escherichia coli W3110 by NCCLS assay	ChEMBL.	21194954
MIC (functional)	= 1.3 ug ml-1	Antibacterial activity against Escherichia coli W3110PA replaced with Pseudomonas aeruginosa lpxC gene by NCCLS assay	ChEMBL.	21194954
MIC (functional)	= 6.3 ug ml-1	Antibacterial activity against Escherichia coli W3110RL replaced with Rhizobium leguminosarum lpxC gene by NCCLS assay	ChEMBL.	21194954

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1643370

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1509696