TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 338.208 | Formula: C10H15N2O9P
H donors: 4 H acceptors: 6 LogP: -3.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1nc(=O)ccn1[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(O)O
InChi: 1S/C10H15N2O9P/c1-19-10-11-6(13)2-3-12(10)9-8(15)7(14)5(21-9)4-20-22(16,17)18/h2-3,5,7-9,14-15H,4H2,1H3,(H2,16,17,18)/t5-,7-,8-,9-/m1/s1
InChiKey: YZHHOKQNKLNAMB-ZOQUXTDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	pyrimidinergic receptor P2Y, G-protein coupled, 6	Starlite/ChEMBL	References
Homo sapiens	purinergic receptor P2Y, G-protein coupled, 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0076	0.0089	0.0329
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0072	0.008	0.625
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0054	0.0039	0.004
Brugia malayi	PXA domain containing protein	0.0708	0.1549	0.1544
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.0089	0.0075
Schistosoma mansoni	oxysterol-binding protein 1	0.0065	0.0064	0.0049
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Entamoeba histolytica	cell surface protease gp63, putative	0.0156	0.0275	0.156
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Echinococcus granulosus	protein tyrosine kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	STE family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.0039	0.004
Loa Loa (eye worm)	TK/ABL protein kinase	0.0054	0.0039	0.0033
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0054	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0054	0.0039	0.004
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0054	0.0039	0.0255
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0082	0.0104	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	myotubularin-related protein	0.0065	0.0064	0.0049
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0076	0.0089	0.0329
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0076	0.0089	0.0329
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	protein kinase	0.0076	0.0089	0.0075
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0065	0.0064	0.375
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Trypanosoma cruzi	PH domain containing protein, putative	0.0065	0.0064	0.375
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Brugia malayi	hypothetical protein	0.0708	0.1549	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0171	0.0165
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0065	0.0064	0.0161
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0039	0.0025
Entamoeba histolytica	PH domain containing protein	0.0065	0.0064	0.0161
Entamoeba histolytica	PH domain containing protein	0.0065	0.0064	0.0161
Brugia malayi	Cadps2 protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0054	0.0039	0.004
Echinococcus multilocularis	oxysterol binding protein 1	0.0065	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0708	0.1549	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0065	0.0064	0.0161
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0104	0.0429
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2639	0.601	0.7183
Echinococcus granulosus	semaphorin 5B	0.0357	0.0738	0.0876
Echinococcus granulosus	Pleckstrin y	0.0065	0.0064	0.0069
Trichomonas vaginalis	protein kinase atn1, putative	0.0054	0.0039	0.0255
Toxoplasma gondii	aurora kinase	0.0076	0.0089	0.7667
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0156	0.0275	0.1776
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0054	0.0039	0.0025
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0708	0.1549	0.1544
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0275	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	actin binding protein anillin	0.0065	0.0064	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Loa Loa (eye worm)	TK/RYK protein kinase	0.0054	0.0039	0.0033
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0708	0.1549	0.1537
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Echinococcus granulosus	twitchin	0.0129	0.0211	0.0245
Echinococcus granulosus	pleckstrin y domain containing family A	0.0065	0.0064	0.0069
Trichomonas vaginalis	alpha chimerin, putative	0.0065	0.0064	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	centaurin alpha, putative	0.0065	0.0064	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	zinc finger protein	0.0065	0.0064	0.0049
Leishmania major	serine/threonine-protein kinase a, putative	0.0082	0.0104	1
Schistosoma mansoni	tyrosine protein kinase	0.0054	0.0039	0.0025
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0065	0.0064	0.0049
Echinococcus multilocularis	aurora kinase A	0.0076	0.0089	0.0099
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus multilocularis	Immunoglobulin	0.0111	0.0171	0.0197
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Echinococcus granulosus	neuroglian	0.0111	0.0171	0.0197
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0059	0.0051	0.0054
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Brugia malayi	Probable exocyst complex component Sec5	0.0156	0.0275	0.0269
Echinococcus granulosus	kinase suppressor of Ras 1	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	Oxysterol-binding protein	0.0065	0.0064	0.0058
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Echinococcus multilocularis	exocyst complex component 2	0.0156	0.0275	0.0322
Echinococcus granulosus	tyrosine protein kinase shark	0.0054	0.0039	0.004
Schistosoma mansoni	dynamin	0.0065	0.0064	0.0049
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0065	0.0064	0.0069
Toxoplasma gondii	Oxysterol-binding protein	0.0065	0.0064	0.375
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0171	0.0165
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0156	0.0275	0.1776
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Onchocerca volvulus	Putative zinc finger protein	0.0065	0.0064	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0738	0.0733
Brugia malayi	serine/threonine-protein kinase 6	0.0076	0.0089	0.0083
Echinococcus granulosus	regulator of G protein signaling 3	0.0708	0.1549	0.1846
Trypanosoma cruzi	PH domain containing protein, putative	0.0065	0.0064	0.375
Echinococcus granulosus	GRB2 associated binding protein 3	0.0065	0.0064	0.0069
Echinococcus granulosus	Pleckstrin y	0.0065	0.0064	0.0069
Schistosoma mansoni	serine/threonine-protein kinase	0.0082	0.0104	0.009
Echinococcus granulosus	c src tyrosine kinase	0.0054	0.0039	0.004
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0054	0.0039	0.004
Schistosoma mansoni	oxysterol-binding protein 1	0.0065	0.0064	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	syntrophin-1	0.0065	0.0064	0.0058
Echinococcus granulosus	tyrosine protein kinase Blk	0.0054	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0171	0.0165
Brugia malayi	MAX-1A	0.0065	0.0064	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	protein kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Leishmania major	protein kinase, putative	0.0072	0.008	0.625
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0065	0.0064	0.0069
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0054	0.0039	0.004
Toxoplasma gondii	protein kinase domain-containing protein	0.0082	0.0104	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0104	0.0429
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0072	0.008	0.625
Echinococcus granulosus	roundabout 2	0.0116	0.0182	0.021
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0054	0.0039	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Schistosoma mansoni	vav2	0.0065	0.0064	0.0049
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0054	0.0039	0.004
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0065	0.0064	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0738	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0708	0.1549	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0708	0.1549	0.1846
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0065	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0211	0.0401	0.2394
Echinococcus multilocularis	c src tyrosine kinase	0.0054	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus granulosus	calcium dependent secretion activator 1	0.0065	0.0064	0.0069
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3658	0.8365	0.8364
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	growth factor receptor-bound protein	0.0065	0.0064	0.0049
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0054	0.0039	0.004
Echinococcus granulosus	protein kinase	0.0054	0.0039	0.004
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0171	0.0165
Echinococcus granulosus	tyrosine kinase	0.0054	0.0039	0.004
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0082	0.0104	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0082	0.0104	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0065	0.0064	0.0069
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Brugia malayi	Plexin repeat family protein	0.0841	0.1857	0.1852
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0082	0.0104	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0054	0.0039	0.004
Schistosoma mansoni	protein tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus granulosus	ephrin type A receptor 4 A	0.0054	0.0039	0.004
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0054	0.0039	0.004
Onchocerca volvulus	Protein melted homolog	0.0065	0.0064	0.0133
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0076	0.0089	0.7667
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Schistosoma mansoni	hypothetical protein	0.0065	0.0064	0.0049
Brugia malayi	SRC-1	0.0054	0.0039	0.0033
Onchocerca volvulus	outspread protein homolog	0.0065	0.0064	0.0133
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0054	0.0039	0.004
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Entamoeba histolytica	protein kinase domain containing protein	0.0072	0.008	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Trichomonas vaginalis	centaurin/arf, putative	0.0065	0.0064	0.0412
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	rho-GTPase-activating	0.0065	0.0064	0.0058
Loa Loa (eye worm)	TK/ROR protein kinase	0.0054	0.0039	0.0033
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Echinococcus granulosus	oxysterol binding protein 9	0.0065	0.0064	0.0069
Echinococcus multilocularis	insulin receptor	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0054	0.0039	0.0025
Brugia malayi	probable spectrin beta chain	0.0065	0.0064	0.0058
Brugia malayi	Cytohesin 3	0.0065	0.0064	0.0058
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Leishmania major	hypothetical protein, conserved	0.0065	0.0064	0.375
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0065	0.0064	0.0069
Echinococcus granulosus	oxysterol binding protein 3	0.0065	0.0064	0.0069
Onchocerca volvulus		0.0065	0.0064	0.0133
Echinococcus granulosus	epidermal growth factor receptor	0.0054	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Brugia malayi	Plekhf2 protein	0.0065	0.0064	0.0058
Brugia malayi	ephrin receptor 1 precursor	0.0054	0.0039	0.0033
Brugia malayi	hypothetical protein	0.0357	0.0738	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Echinococcus multilocularis	oxysterol binding protein 3	0.0065	0.0064	0.0069
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0082	0.0104	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0708	0.1549	0.1846
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0054	0.0039	0.004
Brugia malayi	Oxysterol binding protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0065	0.0064	0.0412
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0089	0.0575
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0065	0.0064	0.0412
Entamoeba histolytica	hypothetical protein	0.0082	0.0104	0.0429
Trichomonas vaginalis	conserved hypothetical protein	0.0708	0.1549	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0054	0.0039	0.004
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0054	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	cytohesin 3	0.0065	0.0064	0.0058
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3347	0.7645	0.9139
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0072	0.008	0.625
Brugia malayi	Raf kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0054	0.0039	0.004
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0065	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0708	0.1549	0.1537
Entamoeba histolytica	hypothetical protein	0.0708	0.1549	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Brugia malayi	hypothetical protein	0.0116	0.0182	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0054	0.0039	0.004
Echinococcus granulosus	dynamin 1	0.0065	0.0064	0.0069
Onchocerca volvulus		0.0065	0.0064	0.0133
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	hypothetical protein	0.0156	0.0275	0.0261
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0082	0.0104	1
Schistosoma mansoni	serine/threonine protein kinase	0.3347	0.7645	0.7642
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Onchocerca volvulus		0.0065	0.0064	0.0133
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Echinococcus granulosus	exocyst complex component 2	0.0156	0.0275	0.0322
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Onchocerca volvulus		0.0065	0.0064	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0708	0.1549	1
Brugia malayi	Fibronectin type III domain containing protein	0.0116	0.0182	0.0176
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0065	0.0064	0.0133
Echinococcus multilocularis	activated cdc42 kinase 1	0.0054	0.0039	0.004
Entamoeba histolytica	hypothetical protein	0.0082	0.0104	0.0429
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Leishmania major	folate/biopterin transporter, putative	0.0082	0.0104	1
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Entamoeba histolytica	hypothetical protein	0.0065	0.0064	0.0161
Loa Loa (eye worm)	TK/Met protein kinase	0.0054	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0059	0.0051	0.0054
Echinococcus granulosus	integrin linked protein kinase	0.0054	0.0039	0.004
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3347	0.7645	0.9139
Echinococcus granulosus	defective proboscis extension response	0.0111	0.0171	0.0197
Echinococcus multilocularis	FL cytokine receptor	0.0054	0.0039	0.004
Onchocerca volvulus		0.0065	0.0064	0.0133
Echinococcus multilocularis	oxysterol binding protein 9	0.0065	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0171	0.0165
Echinococcus multilocularis	tyrosine protein kinase	0.0054	0.0039	0.004
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Brugia malayi	Syntrophin-1	0.0065	0.0064	0.0058
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0275	0.0269
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0072	0.008	0.0088
Entamoeba histolytica	protein kinase, putative	0.0076	0.0089	0.0329
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0082	0.0104	1
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0065	0.0064	0.0133
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	dynamin	0.0065	0.0064	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	activated cdc42 kinase 1	0.0054	0.0039	0.004
Echinococcus multilocularis	regulator of G protein signaling 3	0.0708	0.1549	0.1846
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0054	0.0039	0.0255
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0065	0.0064	0.0069
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0076	0.0089	0.0099
Loa Loa (eye worm)	TK/INSR protein kinase	0.0054	0.0039	0.0033
Echinococcus granulosus	Immunoglobulin	0.0111	0.0171	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0708	0.1549	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0072	0.008	0.625
Brugia malayi	Pleckstrin Homology Domain	0.0065	0.0064	0.0058
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0089	0.0575
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0054	0.0039	0.004
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0166	0.0296	0.029
Schistosoma mansoni	protein kinase	0.0072	0.008	0.0065
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Trichomonas vaginalis	kinesin light chain, putative	0.0065	0.0064	0.0412
Trypanosoma brucei	protein kinase, putative	0.0072	0.008	0.625
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0065	0.0064	0.375
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0082	0.0104	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0065	0.0064	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0082	0.0104	0.0673
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	roundabout 2	0.0116	0.0182	0.021
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Onchocerca volvulus		0.0841	0.1857	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	heat shock protein 70	0.0054	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0054	0.0039	0.004
Echinococcus granulosus	Pleckstrin y	0.0065	0.0064	0.0069
Entamoeba histolytica	hypothetical protein	0.0156	0.0275	0.156
Echinococcus multilocularis	axis inhibition protein axin	0.0708	0.1549	0.1846
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	beta 1 syntrophin	0.0065	0.0064	0.0069
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus granulosus	serine/threonine protein kinase	0.0082	0.0104	0.0117
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0054	0.0039	0.004
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3658	0.8365	0.8364
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	protein kinase	0.0072	0.008	0.0065
Entamoeba histolytica	hypothetical protein	0.0065	0.0064	0.0161
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3658	0.8365	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0082	0.0104	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0054	0.0039	0.004
Schistosoma mansoni	hypothetical protein	0.0065	0.0064	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0054	0.0039	0.0025
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0054	0.0039	0.004
Brugia malayi	integrin-linked kinase	0.0054	0.0039	0.0033
Brugia malayi	Variant SH3 domain containing protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	cytohesin 1	0.0065	0.0064	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0082	0.0104	1
Schistosoma mansoni	nephrin	0.0116	0.0182	0.0168
Onchocerca volvulus		0.0065	0.0064	0.0133
Echinococcus granulosus	tyrosine protein kinase HCK	0.0054	0.0039	0.004
Echinococcus multilocularis	transcription factor collier	0.0156	0.0275	0.0322
Trichomonas vaginalis	TK family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0076	0.0089	0.0329
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	hypothetical protein	0.0357	0.0738	0.0725
Echinococcus multilocularis	Immunoglobulin	0.0111	0.0171	0.0197
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Trypanosoma cruzi	aurora B kinase, putative	0.0076	0.0089	0.7667
Loa Loa (eye worm)	AUR protein kinase	0.0076	0.0089	0.0083
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0082	0.0104	0.0098
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.0039	0.004
Entamoeba histolytica	hypothetical protein	0.0156	0.0275	0.156
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Echinococcus multilocularis	transfer RNA-Thr	0.0054	0.0039	0.004
Schistosoma mansoni	hypothetical protein	0.0065	0.0064	0.0049
Echinococcus multilocularis	regulator of G protein signaling 3	0.0708	0.1549	0.1846
Loa Loa (eye worm)	plexin A	0.0998	0.2218	0.2214
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Loa Loa (eye worm)	hypothetical protein	0.021	0.0399	0.0393
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0065	0.0064	0.0069
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0054	0.0039	0.0025
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	hypothetical protein	0.0065	0.0064	0.0049
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0065	0.0064	0.0069
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.0039	0.004
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0156	0.0275	0.1776
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0039	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0104	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	AUR protein kinase	0.0076	0.0089	0.0083
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Echinococcus granulosus	raf serine:threonine protein kinase	0.0054	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase shark	0.0054	0.0039	0.004
Brugia malayi	serine/threonine protein kinase 6	0.0076	0.0089	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Echinococcus granulosus	regulator of G protein signaling 7	0.0708	0.1549	0.1846
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0065	0.0064	0.375
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0065	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Giardia lamblia	Aurora kinase	0.0076	0.0089	1
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0708	0.1549	0.1846
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	hypothetical protein	0.0708	0.1549	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.0591	0.0585
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Loa Loa (eye worm)	PXA domain-containing protein	0.0708	0.1549	0.1544
Echinococcus granulosus	semaphorin 1A	0.0357	0.0738	0.0876
Echinococcus multilocularis	tyrosine kinase	0.0054	0.0039	0.004
Echinococcus multilocularis	regulator of G protein signaling	0.0708	0.1549	0.1846
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0054	0.0039	0.004
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0054	0.0039	0.0033
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0054	0.0039	0.0025
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0065	0.0064	0.0069
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0065	0.0064	0.375
Trypanosoma brucei	aurora B kinase	0.0076	0.0089	0.7667
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0082	0.0104	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0708	0.1549	0.1846
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0166	0.0296	0.029
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0065	0.0064	0.0161
Entamoeba histolytica	hypothetical protein	0.0065	0.0064	0.0161
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0054	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Echinococcus granulosus	regulator of G protein signaling 7	0.0708	0.1549	0.1846
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0065	0.0064	0.375
Schistosoma mansoni	ephrin receptor	0.0054	0.0039	0.0025
Echinococcus granulosus	Oxysterol binding protein 11	0.0065	0.0064	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus multilocularis	epidermal growth factor receptor	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	PH domain-containing protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0065	0.0064	0.0069
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Echinococcus granulosus	aurora kinase A	0.0076	0.0089	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0065	0.0064	0.0058
Onchocerca volvulus		0.0357	0.0738	0.3845
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3658	0.8365	0.8364
Echinococcus multilocularis	epidermal growth factor receptor	0.0054	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	pdz domain containing protein	0.0065	0.0064	0.0069
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0054	0.0039	0.004
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Trichomonas vaginalis	centaurin beta, putative	0.0065	0.0064	0.0412
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0065	0.0064	0.0161
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Entamoeba histolytica	protein kinase domain containing protein	0.0076	0.0089	0.0329
Brugia malayi	Receptor family ligand binding region containing protein	0.0054	0.0039	0.0033
Schistosoma mansoni	vesicular amine transporter	0.0114	0.0177	0.0162
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0065	0.0064	0.0069
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0065	0.0064	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Echinococcus granulosus	axis inhibition protein axin	0.0708	0.1549	0.1846
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Echinococcus granulosus	axis inhibition protein axin	0.0708	0.1549	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0738	0.0733
Schistosoma mansoni	serine/threonine RGC	0.0054	0.0039	0.0025
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0054	0.0039	0.004
Schistosoma mansoni	hypothetical protein	0.0054	0.0039	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	SH2 domain containing protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0182	0.0176
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Leishmania major	protein kinase, putative	0.0082	0.0104	1
Brugia malayi	Dynamin	0.0065	0.0064	0.0058
Echinococcus multilocularis	activin receptor type	0.0072	0.008	0.0088
Echinococcus granulosus	tyrosine protein kinase Srms	0.0054	0.0039	0.004
Echinococcus granulosus	transcription factor collier	0.0156	0.0275	0.0322
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	plexin a4	0.0998	0.2218	0.2647
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0065	0.0064	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1032	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0275	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Loa Loa (eye worm)	TK/FAK protein kinase	0.0054	0.0039	0.0033
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Schistosoma mansoni	syntrophin	0.0065	0.0064	0.0049
Schistosoma mansoni	goodpasture antigen-binding protein	0.0065	0.0064	0.0049
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0065	0.0064	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	SRC-1	0.0054	0.0039	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0104	0.0429
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0738	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Echinococcus multilocularis	Pleckstrin y	0.0065	0.0064	0.0069
Trypanosoma brucei	PH domain containing protein, putative	0.0065	0.0064	0.375
Echinococcus multilocularis	integrin linked protein kinase	0.0054	0.0039	0.004
Entamoeba histolytica	hypothetical protein	0.0065	0.0064	0.0161
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0708	0.1549	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0082	0.0104	0.009
Echinococcus granulosus	epidermal growth factor receptor	0.0054	0.0039	0.004
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0111	0.0171	0.0156
Brugia malayi	TBC domain containing protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0111	0.0171	0.0197
Entamoeba histolytica	hypothetical protein	0.0065	0.0064	0.0161
Loa Loa (eye worm)	serine/threonine protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	expressed protein	0.0708	0.1549	0.1846
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0076	0.0089	0.7667
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0054	0.0039	0.004
Schistosoma mansoni	rho gtpase activating protein	0.0065	0.0064	0.0049
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0065	0.0064	0.0161
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Schistosoma mansoni	zinc finger protein	0.0065	0.0064	0.0049
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0054	0.0039	0.004
Entamoeba histolytica	protein kinase , putative	0.0076	0.0089	0.0329
Schistosoma mansoni	semaphorin 5-related	0.0357	0.0738	0.0725
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Echinococcus multilocularis	axis inhibition protein axin	0.0708	0.1549	0.1846
Echinococcus granulosus	myotubularin protein 13	0.0065	0.0064	0.0069
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0054	0.0039	0.004
Trypanosoma cruzi	NIMA-related kinase, putative	0.0082	0.0104	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0054	0.0039	0.0255
Echinococcus granulosus	tyrosine kinase	0.0054	0.0039	0.004
Brugia malayi	plexin A	0.0998	0.2218	0.2214
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Brugia malayi	serine/threonine kinase 12	0.0076	0.0089	0.0083
Brugia malayi	PXA domain containing protein	0.0708	0.1549	0.1544
Brugia malayi	SH2 domain containing protein	0.0054	0.0039	0.0033
Brugia malayi	IPT/TIG domain containing protein	0.0156	0.0275	0.0269
Trypanosoma brucei	protein kinase, putative	0.0082	0.0104	1
Loa Loa (eye worm)	hypothetical protein	0.0841	0.1857	0.1852
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Brugia malayi	Uncoordinated protein 104	0.0065	0.0064	0.0058
Schistosoma mansoni	hypothetical protein	0.0156	0.0275	0.0261
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0089	0.0575
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0065	0.0064	0.0069
Loa Loa (eye worm)	TK/ACK protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	Oxysterol binding protein 11	0.0065	0.0064	0.0069
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0054	0.0039	0.004
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3658	0.8365	1
Brugia malayi	Guanylyl cyclase protein 23	0.0054	0.0039	0.0033
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0065	0.0064	0.0069
Trichomonas vaginalis	protein transport protein sec7, putative	0.0065	0.0064	0.0412
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0089	0.0575
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0065	0.0064	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0065	0.0064	0.375
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0065	0.0064	0.0058
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0054	0.0039	0.004
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0054	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.0039	0.004
Entamoeba histolytica	hypothetical protein	0.0156	0.0275	0.156
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0708	0.1549	0.1544
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0104	0.0429
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	Pleckstrin y	0.0065	0.0064	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	regulator of G protein signaling	0.0708	0.1549	0.1537
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0738	0.0733
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Brugia malayi	regulator of G-protein signaling rgs-7	0.0708	0.1549	0.1544
Echinococcus granulosus	tyrosine protein kinase pr2	0.0054	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	RGS-3 protein	0.0708	0.1549	0.1544
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0708	0.1549	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0082	0.0104	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0104	0.0429
Toxoplasma gondii	hypothetical protein	0.0065	0.0064	0.375
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Echinococcus granulosus	expressed protein	0.0708	0.1549	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0039	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Brugia malayi	DNA-binding protein LAG-1	0.0156	0.0275	0.0269
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0054	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0111	0.0171	0.0156
Schistosoma mansoni	hypothetical protein	0.0484	0.1032	0.1019
Echinococcus granulosus	natriuretic peptide receptor 1	0.0054	0.0039	0.004
Schistosoma mansoni	axis inhibition protein axin	0.0708	0.1549	0.1537
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus multilocularis	protein kinase	0.0054	0.0039	0.004
Brugia malayi	Furin-like cysteine rich region family protein	0.0054	0.0039	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0171	0.0165
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	cell adhesion molecule	0.0116	0.0182	0.0168
Echinococcus multilocularis	protein tyrosine kinase	0.0054	0.0039	0.004
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0065	0.0064	0.0069
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Schistosoma mansoni	plexin	0.0841	0.1857	0.1845
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0082	0.0104	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0064	0.0049
Echinococcus granulosus	tyrosine kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Schistosoma mansoni	regulator of G protein signaling	0.0708	0.1549	0.1537
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Onchocerca volvulus		0.0065	0.0064	0.0133
Toxoplasma gondii	AtPH1 family protein	0.0065	0.0064	0.375
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0065	0.0064	0.0069
Brugia malayi	hypothetical protein	0.0065	0.0064	0.0058
Entamoeba histolytica	tyrosin kinase, putative	0.0211	0.0401	0.2394
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0054	0.0039	0.0033
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0082	0.0104	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0054	0.0039	0.0033
Entamoeba histolytica	hypothetical protein, conserved	0.0065	0.0064	0.0161
Brugia malayi	Sema domain containing protein	0.0357	0.0738	0.0733
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Schistosoma mansoni	axis inhibition protein axin	0.0708	0.1549	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0182	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0054	0.0039	0.0033
Echinococcus granulosus	beta 1 syntrophin	0.0065	0.0064	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0065	0.0064	0.0069
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0082	0.0104	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0054	0.0039	0.004
Entamoeba histolytica	p21-activated kinase	0.0082	0.0104	0.0429
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0708	0.1549	1
Plasmodium falciparum	oxysterol-binding protein, putative	0.0065	0.0064	0.375
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK/CSK protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	z-protein (S1r protein)	0.0708	0.1549	0.1537
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0065	0.0064	0.375
Schistosoma mansoni	ephrin receptor	0.0059	0.0051	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.3347	0.7645	0.7642
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0082	0.0104	1
Trichomonas vaginalis	centaurin gamma, putative	0.0065	0.0064	0.0412
Echinococcus granulosus	Rho GTPase activating protein 24	0.0065	0.0064	0.0069
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0065	0.0064	0.0069
Brugia malayi	Sema domain containing protein	0.0357	0.0738	0.0733
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0156	0.0275	0.1776
Plasmodium falciparum	protein kinase, putative	0.0072	0.008	0.625
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	plexin a4	0.0998	0.2218	0.2647
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0065	0.0064	0.375
Echinococcus granulosus	tyrosine protein kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0275	0.1776
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0708	0.1549	1
Trichomonas vaginalis	hypothetical protein	0.0065	0.0064	0.0412
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0054	0.0039	0.0025
Echinococcus granulosus	DCC interacting protein 13 beta	0.0065	0.0064	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Echinococcus multilocularis	neuroglian	0.0111	0.0171	0.0197
Echinococcus multilocularis	hypothetical protein	0.0357	0.0738	0.0876
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0065	0.0064	0.0049
Brugia malayi	regulator of G-protein signaling egl-10	0.0708	0.1549	0.1544
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0076	0.0089	0.0099
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0708	0.1549	0.1537
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Brugia malayi	hypothetical protein	0.0357	0.0738	0.0733
Entamoeba histolytica	protein kinase, putative	0.0082	0.0104	0.0429
Echinococcus granulosus	oxysterol binding protein 1	0.0065	0.0064	0.0069
Loa Loa (eye worm)	TK/ALK protein kinase	0.0293	0.0591	0.0585
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0708	0.1549	0.1846
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0072	0.008	0.0088
Trypanosoma cruzi	PH domain containing protein, putative	0.0065	0.0064	0.375
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0065	0.0064	0.0069
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3347	0.7645	0.7644
Trichomonas vaginalis	centaurin/arf, putative	0.0065	0.0064	0.0412
Loa Loa (eye worm)	sema domain-containing protein	0.0357	0.0738	0.0733
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0054	0.0039	0.004
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2639	0.601	0.7183
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0082	0.0104	1
Loa Loa (eye worm)	sema domain-containing protein	0.0357	0.0738	0.0733
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0065	0.0064	0.0161
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0054	0.0039	0.004
Echinococcus multilocularis	regulator of G protein signaling 7	0.0708	0.1549	0.1846
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	protein transport protein sec7, putative	0.0065	0.0064	0.0412
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Brugia malayi	Dynamin	0.0065	0.0064	0.0058
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0065	0.0064	0.0069
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Entamoeba histolytica	hypothetical protein	0.0156	0.0275	0.156
Echinococcus granulosus	receptor type guanylyl cyclase	0.0054	0.0039	0.004
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0054	0.0039	0.0033
Schistosoma mansoni	protein kinase	0.0054	0.0039	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0708	0.1549	0.1544
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0082	0.0104	0.0673
Echinococcus granulosus	Regulator of G protein signaling 20	0.0708	0.1549	0.1846
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0039	0.0033
Entamoeba histolytica	PH domain containing protein	0.0065	0.0064	0.0161
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0054	0.0039	0.004
Echinococcus multilocularis	Pleckstrin y	0.0065	0.0064	0.0069
Trypanosoma cruzi	Protein kinase B	0.0082	0.0104	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0054	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0182	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus multilocularis	tyrosine kinase	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Plasmodium vivax	hypothetical protein, conserved	0.0065	0.0064	0.375
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	dynamin 1	0.0065	0.0064	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Schistosoma mansoni	plexin	0.0484	0.1032	0.1019
Leishmania major	hypothetical protein, conserved	0.0065	0.0064	0.375
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0065	0.0064	0.375
Loa Loa (eye worm)	hypothetical protein	0.0708	0.1549	0.1544
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0065	0.0064	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0054	0.0039	0.0255
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0054	0.0039	0.0033
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0708	0.1549	0.1544
Schistosoma mansoni	hypothetical protein	0.0357	0.0738	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0039	0.0025
Brugia malayi	protein-tyrosine kinase	0.0054	0.0039	0.0033
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0065	0.0064	0.0412
Brugia malayi	C-terminal src kinase protein 1	0.0054	0.0039	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0039	0.0025
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0054	0.0039	0.0255
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Plasmodium vivax	PH domain containing protein	0.0065	0.0064	0.375
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0054	0.0039	0.004
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0116	0.0182	0.0176
Echinococcus granulosus	insulin receptor	0.0054	0.0039	0.004
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0156	0.0275	0.1776
Loa Loa (eye worm)	uncoordinated protein 104	0.0065	0.0064	0.0058
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0039	0.0033
Echinococcus granulosus	activin receptor type	0.0072	0.008	0.0088
Leishmania major	protein kinase, putative	0.0076	0.0089	0.7667
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0111	0.0171	0.0197
Schistosoma mansoni	goodpasture antigen-binding protein	0.0065	0.0064	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0064	0.0058
Echinococcus granulosus	activated cdc42 kinase 1	0.0054	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	cytohesin 1	0.0065	0.0064	0.0069
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Plasmodium falciparum	PH domain-containing protein, putative	0.0065	0.0064	0.375
Loa Loa (eye worm)	TK/DDR protein kinase	0.0054	0.0039	0.0033
Loa Loa (eye worm)	oxysterol binding protein	0.0065	0.0064	0.0058
Brugia malayi	Variant SH3 domain containing protein	0.0065	0.0064	0.0058
Echinococcus multilocularis	pdz domain containing protein	0.0065	0.0064	0.0069
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0054	0.0039	0.004
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0082	0.0104	1
Brugia malayi	PH domain containing protein	0.0065	0.0064	0.0058
Loa Loa (eye worm)	TK/EPH protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	myotubularin protein 13	0.0065	0.0064	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Brugia malayi	hypothetical protein	0.0708	0.1549	0.1544
Schistosoma mansoni	fibrocystin l	0.0156	0.0275	0.0261
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Leishmania major	protein kinase, putative	0.0082	0.0104	1
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0065	0.0064	0.0058
Schistosoma mansoni	protein kinase	0.0072	0.008	0.0065
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0065	0.0064	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0708	0.1549	0.1544
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0054	0.0039	0.004
Trypanosoma cruzi	hypothetical protein	0.0065	0.0064	0.375
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Toxoplasma gondii	hypothetical protein	0.0065	0.0064	0.375
Schistosoma mansoni	regulator of G protein signaling	0.0708	0.1549	0.1537
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0025
Trypanosoma cruzi	NIMA-related kinase, putative	0.0082	0.0104	1
Echinococcus multilocularis	semaphorin 5B	0.0357	0.0738	0.0876
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0064	0.0412
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0082	0.0104	1
Schistosoma mansoni	regulator of G protein signaling	0.0708	0.1549	0.1537
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0054	0.0039	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0039	0.0025
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0072	0.008	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0275	0.0269
Schistosoma mansoni	centaurin alpha	0.0065	0.0064	0.0049
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0054	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Loa Loa (eye worm)	Plekhf2 protein	0.0065	0.0064	0.0058
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0065	0.0064	0.0049
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0065	0.0064	0.375
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Entamoeba histolytica	hypothetical protein	0.0708	0.1549	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0039	0.0033
Trypanosoma cruzi	PH domain containing protein, putative	0.0065	0.0064	0.375
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0082	0.0104	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0708	0.1549	0.1544
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0708	0.1549	0.1544
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0054	0.0039	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0738	0.0733
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0104	0.0673
Loa Loa (eye worm)	AUR protein kinase	0.0076	0.0089	0.0083
Echinococcus multilocularis	rac serine:threonine kinase	0.0082	0.0104	0.0117
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0054	0.0039	0.004
Schistosoma mansoni	regulator of G protein signaling	0.0708	0.1549	0.1537
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.0039	0.0255
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0054	0.0039	0.004

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 9.8 uM	Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay	ChEMBL.	21417463
EC50 (functional)	= 9.9 uM	Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay	ChEMBL.	21417463
EC50 (functional)	> 100 uM	Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay	ChEMBL.	21417463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1767422

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1510198