Detailed information for compound 1520073

Basic information

Technical information
  • TDR Targets ID: 1520073
  • Name: 2-[2-[2-(2-methoxyphenoxy)ethylsulfanyl]benzi midazol-1-yl]ethanol
  • MW: 344.428 | Formula: C18H20N2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1c(SCCOc2ccccc2OC)nc2c1cccc2
  • InChi: 1S/C18H20N2O3S/c1-22-16-8-4-5-9-17(16)23-12-13-24-18-19-14-6-2-3-7-15(14)20(18)10-11-21/h2-9,21H,10-13H2,1H3
  • InChiKey: JPTVHJWPHHADPL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[2-[2-(2-methoxyphenoxy)ethylthio]-1-benzimidazolyl]ethanol
  • 2-[2-[2-(2-methoxyphenoxy)ethylthio]benzimidazol-1-yl]ethanol
  • 2-{2-[2-(2-Methoxy-phenoxy)-ethylsulfanyl]-benzoimidazol-1-yl}-ethanol
  • BAS 00253416
  • MLS000711399
  • SMR000281166
  • ChemDiv1_000333

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0033 0.0481 0.0481
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.01 0.2564 0.3025
Schistosoma mansoni hypothetical protein 0.0023 0.0145 0.0266
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0576
Echinococcus multilocularis RUN 0.0022 0.0114 0.0114
Trypanosoma brucei beta lactamase 0.0069 0.1613 0.6293
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0481 0.0568
Mycobacterium ulcerans hypothetical protein 0.0033 0.0481 0.097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0671 0.0671
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0334 0.1021
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0021 0.0039
Trichomonas vaginalis apoptosis inducing factor, putative 0.0033 0.0481 0.0568
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0125
Toxoplasma gondii exonuclease III APE 0.0023 0.0148 0.0576
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.3674 0.4335
Trichomonas vaginalis chromobox protein, putative 0.0046 0.088 0.1039
Loa Loa (eye worm) hypothetical protein 0.0122 0.3268 0.3856
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.01 0.2564 0.6389
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0033 0.0481 0.1878
Schistosoma mansoni ap endonuclease 0.0023 0.0148 0.0272
Mycobacterium tuberculosis Conserved protein 0.0033 0.0481 0.1055
Brugia malayi follicle stimulating hormone receptor 0.0247 0.7184 0.8477
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0211 0.039
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0981 0.1809
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0481 0.0568
Trichomonas vaginalis A-type flavoprotein 0.0033 0.0481 0.0568
Mycobacterium leprae POSSIBLE HYDROLASE 0.0033 0.0481 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0481 0.0568
Brugia malayi Doublecortin family protein 0.0022 0.0114 0.0135
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0033 0.0481 0.0568
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0033 0.0481 0.1878
Treponema pallidum ribonuclease Z 0.0033 0.0481 0.1382
Echinococcus multilocularis chromobox protein 1 0.0076 0.1832 0.1832
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.8475 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0114 0.0114
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0122 0.3268 0.3268
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0148 0.0148
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.1489 0.1489
Echinococcus multilocularis chromobox protein 1 0.0076 0.1832 0.1832
Echinococcus granulosus zinc phosphodiesterase 0.0033 0.0481 0.0481
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0148 0.0174
Loa Loa (eye worm) hypothetical protein 0.0033 0.0481 0.0568
Loa Loa (eye worm) hypothetical protein 0.0033 0.0481 0.0568
Mycobacterium ulcerans hypothetical protein 0.0033 0.0481 0.097
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0033 0.0481 0.1473
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0148 0.02
Mycobacterium tuberculosis Possible hydrolase 0.0033 0.0481 0.1055
Echinococcus granulosus eukaryotic initiation factor 4A III 0.01 0.2564 0.2564
Mycobacterium ulcerans hypothetical protein 0.0033 0.0481 0.097
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0122 0.3268 0.3856
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0481 0.1473
Brugia malayi hypothetical protein 0.0022 0.0114 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0481 0.0568
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0211 0.0211
Mycobacterium ulcerans beta lactamase-like protein 0.0033 0.0481 0.097
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0481 0.1055
Brugia malayi ethe1-prov protein 0.0033 0.0481 0.0568
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0021 0.0039
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0033 0.0481 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.021 0.0388
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0145 0.0171
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0021 0.0021
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0481 0.0568
Trichomonas vaginalis chromobox protein, putative 0.0076 0.1832 0.2162
Schistosoma mansoni hypothetical protein 0.0033 0.0481 0.0888
Brugia malayi PHD-finger family protein 0.0027 0.0292 0.0344
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0334 0.1021
Trichomonas vaginalis cdc25c, putative 0.0122 0.3268 0.3856
Echinococcus multilocularis muscleblind protein 1 0.0155 0.4304 0.4304
Loa Loa (eye worm) hypothetical protein 0.0113 0.2969 0.3503
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0211 0.0211
Mycobacterium ulcerans glyoxalase II, GloB 0.0033 0.0481 0.097
Loa Loa (eye worm) hypothetical protein 0.0113 0.2969 0.3503
Loa Loa (eye worm) hypothetical protein 0.0043 0.0778 0.0918
Mycobacterium tuberculosis Beta lactamase like protein 0.0033 0.0481 0.1055
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3674 0.6775
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.021 0.021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0148 0.0107
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0033 0.0481 0.1878
Echinococcus granulosus chromobox protein 1 0.0076 0.1832 0.1832
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0122 0.3268 0.3856
Trichomonas vaginalis cdc25b, putative 0.0122 0.3268 0.3856
Schistosoma mansoni zinc finger protein 0.0021 0.0108 0.0199
Loa Loa (eye worm) hypothetical protein 0.0029 0.0334 0.0394
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0069 0.1613 1
Echinococcus multilocularis geminin 0.0165 0.462 0.462
Brugia malayi TAR-binding protein 0.0135 0.3674 0.4335
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.7502 0.8852
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0334 0.0394
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.5423 0.6399
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0069 0.1613 0.3954
Onchocerca volvulus 0.0122 0.3268 0.6005
Brugia malayi hypothetical protein 0.0033 0.0481 0.0568
Schistosoma mansoni chromobox protein 0.0076 0.1832 0.3378
Entamoeba histolytica hypothetical protein 0.0025 0.0211 0.0646
Entamoeba histolytica rodhanase-like domain containing protein 0.0122 0.3268 1
Treponema pallidum ATP-dependent RNA helicase 0.01 0.2564 1
Schistosoma mansoni hypothetical protein 0.0165 0.462 0.852
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0386 0.0455
Echinococcus granulosus RUN 0.0022 0.0114 0.0114
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0122 0.3268 0.3856
Echinococcus granulosus zinc finger protein 0.0021 0.0108 0.0108
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0033 0.0481 0.097
Leishmania major hypothetical protein, conserved 0.0033 0.0481 0.1878
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0033 0.0481 0.0568
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.088 0.1459
Trypanosoma brucei glyoxalase II 0.0033 0.0481 0.1878
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.01 0.2564 0.2564
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0778 0.1265
Mycobacterium ulcerans hydrolase 0.0033 0.0481 0.097
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0033 0.0481 0.1878
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Trichomonas vaginalis chromobox protein, putative 0.0046 0.088 0.1039
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0145 0.3974 1
Mycobacterium tuberculosis Conserved protein 0.0033 0.0481 0.1055
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0148 0.0174
Echinococcus granulosus tar DNA binding protein 0.0135 0.3674 0.3674
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0021 0.0021
Loa Loa (eye worm) TAR-binding protein 0.0135 0.3674 0.4335
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0778 0.0918
Mycobacterium tuberculosis Conserved protein 0.0033 0.0481 0.1055
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.5366 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0334 0.0394
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0481 0.1473
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0122 0.3268 0.3856
Mycobacterium ulcerans hypothetical protein 0.0029 0.0334 0.0588
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0334 0.1301
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0122 0.3268 0.3856
Onchocerca volvulus 0.0049 0.0981 0.165
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0778 0.0918
Brugia malayi Rhodanese-like domain containing protein 0.0122 0.3268 0.3856
Schistosoma mansoni zinc phosphodiesterase 0.0033 0.0481 0.0888
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0481 0.1473
Onchocerca volvulus 0.0034 0.0488 0.0712
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.5685 0.6709
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0114 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0125
Echinococcus granulosus ETHE1 protein 0.0033 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0033 0.0481 0.0568
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0671 0.0671
Schistosoma mansoni ap endonuclease 0.0023 0.0148 0.0272
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0135
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0148 0.0576
Echinococcus granulosus muscleblind protein 0.0155 0.4304 0.4304
Brugia malayi hypothetical protein 0.0022 0.0114 0.0135
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0148 0.0174
Echinococcus multilocularis zinc finger protein 0.0021 0.0108 0.0108
Schistosoma mansoni lipoxygenase 0.0129 0.35 0.6455
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0033 0.0481 0.1878
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0211 0.0824
Plasmodium falciparum eukaryotic initiation factor 4A 0.01 0.2564 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.5423 1
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0033 0.0481 0.1878
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.5423 0.5423
Plasmodium vivax RNA helicase-1, putative 0.01 0.2564 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0334 0.0676
Schistosoma mansoni lipoxygenase 0.0091 0.2277 0.4199
Onchocerca volvulus 0.0122 0.3268 0.6005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.5423 0.6399
Loa Loa (eye worm) hypothetical protein 0.0049 0.0981 0.1158
Onchocerca volvulus 0.0033 0.0481 0.0699
Trypanosoma cruzi glyoxalase II 0.0033 0.0481 0.1878
Echinococcus granulosus geminin 0.0165 0.462 0.462
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0125
Schistosoma mansoni rab6-interacting 0.0022 0.0114 0.0211
Brugia malayi Heterochromatin protein 1 0.0076 0.1832 0.2162
Brugia malayi RNA binding protein 0.0135 0.3674 0.4335
Brugia malayi Bromodomain containing protein 0.0042 0.0752 0.0888
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0334 0.1301
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0114 0.0114
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0114 0.0114
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.1377 0.2539
Brugia malayi MH2 domain containing protein 0.0257 0.7502 0.8852
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.1489 0.1489
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.8475 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0106 0.0094
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0481 0.1156
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0211 0.0824
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0288 0.8475 1
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0481 0.1156
Brugia malayi eukaryotic initiation factor 4A 0.01 0.2564 0.3025
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0001 0.0004
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0033 0.0481 0.1878
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0114 0.0114
Entamoeba histolytica rodhanase-like domain containing protein 0.0122 0.3268 1
Mycobacterium ulcerans lipoprotein LpqF 0.0069 0.1613 0.3897
Brugia malayi Bromodomain containing protein 0.0082 0.2015 0.2378
Leishmania major eukaryotic initiation factor 4a, putative 0.01 0.2564 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.01 0.2564 1
Brugia malayi chromobox protein homolog 3 0.0043 0.0778 0.0918
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0145 0.3974 1
Schistosoma mansoni hypothetical protein 0.0022 0.0114 0.0211
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0148 0.0576
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.7502 0.8852
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Onchocerca volvulus 0.0122 0.3268 0.6005
Leishmania major metallo-beta-lactamase family-like protein 0.0033 0.0481 0.1878
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0211 0.0249
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0033 0.0481 0.1527
Schistosoma mansoni hypothetical protein 0.0165 0.462 0.852
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0334 0.0588
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3674 0.6775
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0386 0.0455
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.35 0.35
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0334 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0334 0.0588
Schistosoma mansoni hypothetical protein 0.0033 0.0481 0.0888
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.8475 1
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0114 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0102 0.04
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0334 0.0588
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.01 0.2564 0.4728
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0334 0.0588
Echinococcus granulosus eukaryotic initiation factor 4A 0.01 0.2564 0.2564
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0033 0.0481 0.1878
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0148 0.0174
Mycobacterium leprae Beta-lactamase-like protein 0.0033 0.0481 0.1156
Schistosoma mansoni hypothetical protein 0.0033 0.0481 0.0888
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0125
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.01 0.2564 0.3025
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.1832 0.2162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.1377 0.3285
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0021 0.0039
Schistosoma mansoni rab6-interacting 0.0022 0.0114 0.0211
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.35 0.35
Loa Loa (eye worm) hypothetical protein 0.0029 0.0334 0.0394
Mycobacterium ulcerans hydrolase 0.0033 0.0481 0.097
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0148 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3674 0.6775
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3674 0.6775
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0481 0.0568
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0042 0.005
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0033 0.0481 0.0481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.5423 1
Giardia lamblia Translation initiation factor eIF-4A, putative 0.01 0.2564 1
Trichomonas vaginalis chromobox protein, putative 0.0076 0.1832 0.2162
Loa Loa (eye worm) RNA binding protein 0.0135 0.3674 0.4335
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0033 0.0481 0.0481
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.01 0.2564 0.3025
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1246 0.147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0148 0.0576
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.5685 0.6709
Brugia malayi metallo-beta-lactamase superfamily protein 0.0033 0.0481 0.0568
Echinococcus multilocularis eukaryotic initiation factor 4A 0.01 0.2564 0.2564
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0148 0.0452
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.8475 1
Schistosoma mansoni polycystin 1-related 0.0022 0.0114 0.0211
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0033 0.0481 0.0888
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.7184 0.8477
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0033 0.0481 0.0481
Trypanosoma cruzi glyoxalase II 0.0033 0.0481 0.1878
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0121
Mycobacterium ulcerans hypothetical protein 0.0033 0.0481 0.097
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0334 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0211 0.0249
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0334 0.0676
Entamoeba histolytica rodhanase-like domain containing protein 0.0122 0.3268 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0334 0.0394
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0481 0.1055
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.8475 1
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.3674 0.4335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0481 0.0568
Onchocerca volvulus 0.0033 0.0481 0.0699
Loa Loa (eye worm) hypothetical protein 0.0122 0.3268 0.3856
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0481 0.1055
Echinococcus granulosus chromobox protein 1 0.0076 0.1832 0.1832
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0481 0.0568
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0148 0.0168
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0334 0.0588
Mycobacterium tuberculosis Possible hydrolase 0.0033 0.0481 0.1055
Trypanosoma cruzi glyoxalase II 0.0033 0.0481 0.1878
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0334 0.1021
Brugia malayi Muscleblind-like protein 0.0155 0.4304 0.5079
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0033 0.0481 0.1878
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0021 0.0021
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.1377 0.5371
Echinococcus multilocularis muscleblind protein 0.0155 0.4304 0.4304
Leishmania major eukaryotic initiation factor 4a, putative 0.01 0.2564 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.5423 0.5423
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0114 0.0114
Onchocerca volvulus Putative hydrolase PNKD 0.0033 0.0481 0.0699
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.01 0.2564 1
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0481 0.0568
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.01 0.2564 0.4664
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.8475 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.5423 1
Loa Loa (eye worm) hypothetical protein 0.01 0.2564 0.3025
Brugia malayi Rhodanese-like domain containing protein 0.0122 0.3268 0.3856
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0481 0.0568
Loa Loa (eye worm) hypothetical protein 0.0155 0.4304 0.5079
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0122 0.3268 0.3268
Loa Loa (eye worm) hypothetical protein 0.0047 0.0902 0.1064
Onchocerca volvulus 0.0122 0.3268 0.6005
Entamoeba histolytica alkyl sulfatase, putative 0.0033 0.0481 0.1473
Loa Loa (eye worm) hypothetical protein 0.0042 0.0755 0.0891
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.021 0.021
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.01 0.2564 1
Leishmania major metallo-beta-lactamase family protein-like protein 0.0033 0.0481 0.1878
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0481 0.1473
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0114 0.0114
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0033 0.0481 0.1878
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0033 0.0481 0.1878
Chlamydia trachomatis ribonuclease Z 0.0033 0.0481 1
Entamoeba histolytica type A flavoprotein, putative 0.0033 0.0481 0.1473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.5423 0.5423
Trichomonas vaginalis cdc25b, putative 0.0122 0.3268 0.3856
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0025
Mycobacterium ulcerans hydrolase 0.0033 0.0481 0.097
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0033 0.0481 0.1473
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0481 0.0568
Echinococcus multilocularis zinc phosphodiesterase 0.0033 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0125
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0033 0.0481 0.0481
Schistosoma mansoni chromobox protein 0.0076 0.1832 0.3378
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0033 0.0481 0.1878
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.01 0.2564 0.4728
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0033 0.0481 0.1878
Schistosoma mansoni loxhd1 0.0022 0.0114 0.0211
Loa Loa (eye worm) hypothetical protein 0.0155 0.4304 0.5079
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0288 0.8475 1
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0033 0.0481 0.1878
Entamoeba histolytica alkyl sulfatase, putative 0.0033 0.0481 0.1473
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0148 0.0576
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.5366 0.6332
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.1377 0.1377
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0211 0.0824
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.1377 0.1377
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0114 0.0032
Plasmodium vivax unspecified product 0.0033 0.0481 0.1527
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0148 0.0576
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0033 0.0481 0.0568
Entamoeba histolytica type A flavoprotein, putative 0.0033 0.0481 0.1473
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0334 0.1301
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.01 0.2564 0.7845
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0334 0.0394
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0033 0.0481 0.0568
Plasmodium falciparum cytosolic glyoxalase II 0.0033 0.0481 0.1527
Onchocerca volvulus 0.0029 0.0334 0.0418
Loa Loa (eye worm) hypothetical protein 0.0077 0.1868 0.2204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.5423 0.5423
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0033 0.0481 0.1878
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.1377 0.1625
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.01 0.2564 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0033 0.0481 0.1878
Brugia malayi metallo-beta-lactamase superfamily protein 0.0033 0.0481 0.0568
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.1377 0.3285
Loa Loa (eye worm) hypothetical protein 0.0045 0.0836 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0481 0.0568
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0148 0.0148
Echinococcus multilocularis ETHE1 protein 0.0033 0.0481 0.0481
Echinococcus multilocularis tumor protein p63 0.0336 1 1
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0033 0.0481 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0481 0.0568
Echinococcus multilocularis tar DNA binding protein 0.0135 0.3674 0.3674
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.1377 0.3349
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0033 0.0481 0.0699
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0481 0.0568
Schistosoma mansoni bromodomain containing protein 0.0069 0.1612 0.2973
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0122 0.3268 0.6026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0021 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3674 0.6775
Schistosoma mansoni zinc phosphodiesterase 0.0033 0.0481 0.0888

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0141 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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