Detailed information for compound 1526133

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 616.659 | Formula: C32H29FN4O6S
  • H donors: 0 H acceptors: 5 LogP: 3.56 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: FCCOCCOc1ccc(cc1)CN1c2ccc(cc2C(=C(C#N)C#N)C1=O)S(=O)(=O)N1CC[C@H]1COc1ccccc1
  • InChi: 1S/C32H29FN4O6S/c33-13-15-41-16-17-42-27-8-6-23(7-9-27)21-36-30-11-10-28(18-29(30)31(32(36)38)24(19-34)20-35)44(39,40)37-14-12-25(37)22-43-26-4-2-1-3-5-26/h1-11,18,25H,12-17,21-22H2/t25-/m0/s1
  • InChiKey: XRPCYJXACIMBQT-VWLOTQADSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL References
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL References
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References
Homo sapiens caspase 6, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Brugia malayi Cell death protein 3 precursor caspase 6, apoptosis-related cysteine peptidase 293 aa 270 aa 34.4 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.006 0.0049 0.0099
Echinococcus granulosus tyrosine protein kinase Src42A 0.008 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0124 0.0717
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Trypanosoma brucei Metacaspase-4 0.0118 0.0124 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.1228 0.1592 0.1592
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0018
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1228 0.1592 0.173
Echinococcus granulosus neuropeptide FF receptor 2 0.1695 0.221 0.221
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0209 0.1238
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0167 0.019 0.0207
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0009 0.001
Leishmania major beta tubulin 0.1257 0.1631 1
Loa Loa (eye worm) brahma associated protein 0.018 0.0208 0.0226
Brugia malayi neuropeptide F receptor 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0012 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0044 0.009
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0044 0.0188
Toxoplasma gondii beta-tubulin, putative 0.1257 0.1631 0.396
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0025
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0076 0.007 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0044 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Loa Loa (eye worm) guanylate kinase 0.003 0.0008 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0116 0.0122 0.0591
Echinococcus granulosus caspase 2 0.0167 0.019 0.019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0705
Echinococcus multilocularis g protein coupled receptor 0.1228 0.1592 0.1592
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Toxoplasma gondii subtilisin SUB11 0.006 0.0049 0.0104
Echinococcus granulosus sex peptide receptor 0.1228 0.1592 0.1592
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0316 0.1897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Echinococcus multilocularis membrane bound transcription factor site 1 0.006 0.0049 0.0049
Leishmania major subtilisin-like serine peptidase 0.006 0.0049 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0044 0.0048
Trichomonas vaginalis tubulin gamma chain, putative 0.1257 0.1631 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0244 0.0292 0.1747
Schistosoma mansoni retinoic acid receptor RXR 0.0057 0.0044 0.009
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0244 0.0292 0.1747
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.014 0.0155 0.0155
Brugia malayi Furin-like cysteine rich region family protein 0.016 0.018 0.0196
Onchocerca volvulus 0.1228 0.1592 0.6804
Trypanosoma brucei hypothetical protein 0.0116 0.0122 0.0591
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0057 0.0044 0.0044
Schistosoma mansoni tubulin subunit beta 0.1257 0.1631 0.3323
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0034 0.0034
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.018 0.0208 0.1229
Echinococcus granulosus tyrosine protein kinase Blk 0.0086 0.0083 0.0083
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0012 0.0012
Plasmodium vivax histone deacetylase, putative 0.0105 0.0108 0.0614
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis disks large 1 0.003 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0229 0.0468
Trypanosoma cruzi metacaspase, putative 0.0118 0.0124 0.0717
Echinococcus multilocularis disks large 3 0.0037 0.0018 0.0018
Echinococcus multilocularis fibrillin 2 0.003 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Srms 0.0086 0.0083 0.0083
Echinococcus granulosus MAGUK p55 subfamily 0.0037 0.0018 0.0018
Leishmania major beta tubulin 0.1257 0.1631 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1228 0.1592 0.1592
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0012 0.0013
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1228 0.1592 0.1592
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0197 0.0229 0.0249
Leishmania major beta tubulin 0.1257 0.1631 1
Giardia lamblia Neurogenic locus Notch protein precursor 0.003 0.0009 0.0003
Echinococcus granulosus disks large 1 0.003 0.0008 0.0008
Echinococcus granulosus ring and YY1 binding protein 0.0064 0.0054 0.0054
Echinococcus granulosus neuropeptide s receptor 0.1228 0.1592 0.1592
Schistosoma mansoni maguk P55 subfamily member 26 0.003 0.0008 0.0016
Echinococcus granulosus growth factor receptor bound protein 2 0.0031 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0061 0.0049 0.0053
Trypanosoma cruzi WLM domain containing protein, putative 0.0064 0.0054 0.0282
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0015 0.003
Brugia malayi Serotonin receptor 0.1228 0.1592 0.173
Echinococcus multilocularis NMDA receptor 0.0033 0.0012 0.0012
Schistosoma mansoni tubulin subunit beta 0.1257 0.1631 0.3323
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0044 0.0188
Brugia malayi hypothetical protein 0.003 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.1228 0.1592 0.3243
Leishmania major beta tubulin 0.1257 0.1631 1
Echinococcus granulosus tubulin beta 1 chain 0.1257 0.1631 0.1631
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0016 0.0018
Loa Loa (eye worm) endoprotease bli-4 0.1312 0.1703 0.1851
Echinococcus granulosus 7tm_1 domain containing protein 0.1228 0.1592 0.1592
Giardia lamblia Tenascin-like 0.003 0.0009 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.1538 0.2002 0.2002
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Brugia malayi Histone deacetylase 1 0.0244 0.0292 0.0317
Loa Loa (eye worm) follicle stimulating hormone receptor 0.181 0.2361 0.2566
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0025
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0194 0.0226 0.537
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0273 0.033 0.1983
Brugia malayi hypothetical protein 0.0027 0.0004 0.0005
Trypanosoma brucei peptidase, putative 0.0071 0.0063 0.0283
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0054 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0002
Schistosoma mansoni tubulin subunit beta 0.1257 0.1631 0.3323
Brugia malayi Hemopexin family protein 0.003 0.0009 0.001
Brugia malayi Tubulin beta-1 chain 0.1257 0.1631 0.1772
Echinococcus granulosus p2X purinoceptor 4 0.0134 0.0146 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0054 0.0237
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Echinococcus granulosus caspase 0.0293 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0067 0.0058 0.0063
Echinococcus multilocularis c src tyrosine kinase 0.0071 0.0063 0.0063
Trypanosoma cruzi peptidase, putative 0.0071 0.0063 0.0337
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0064 0.0054 0.0237
Loa Loa (eye worm) hypothetical protein 0.0114 0.012 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.1228 0.1592 0.3243
Brugia malayi nuclear receptor NHR-88 0.0027 0.0004 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0044 0.0048
Brugia malayi neuropeptide F receptor 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.003 0.0008 0.5
Brugia malayi Matrixin family protein 0.005 0.0035 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.041 0.2474
Schistosoma mansoni histone deacetylase 4 5 0.022 0.0259 0.0529
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0209 0.0245 0.0266
Echinococcus multilocularis integrin alpha ps 0.0032 0.0012 0.0012
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0012 0.0012
Trypanosoma brucei subtilisin peptidase 0.006 0.0049 0.021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0044 0.009
Trypanosoma cruzi metacaspase, putative 0.0118 0.0124 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0058
Echinococcus multilocularis G-protein coupled receptor, putative 0.1228 0.1592 0.1592
Brugia malayi EGF-like domain containing protein 0.003 0.0009 0.0009
Brugia malayi DIX domain containing protein 0.0025 0.0002 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.1228 0.1592 0.1592
Onchocerca volvulus 0.0039 0.002 0.0086
Plasmodium vivax tubulin beta chain, putative 0.1257 0.1631 1
Trypanosoma brucei beta tubulin 0.1257 0.1631 0.8382
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0009 0.0009
Giardia lamblia Beta tubulin 0.1257 0.1631 1
Echinococcus granulosus g protein coupled receptor 0.1228 0.1592 0.1592
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0009 0.0009
Entamoeba histolytica protein kinase, putative 0.0071 0.0063 0.0336
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0795 0.102 0.102
Loa Loa (eye worm) hypothetical protein 0.0083 0.0079 0.0086
Echinococcus granulosus tachykinin peptides receptor 99D 0.1228 0.1592 0.1592
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0043 0.0026 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0044 0.0048
Loa Loa (eye worm) TK/ABL protein kinase 0.0241 0.0287 0.0312
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0282
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1228 0.1592 0.3243
Echinococcus granulosus biogenic amine 5HT receptor 0.1594 0.2076 0.2076
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Toxoplasma gondii subtilisin SUB7 0.006 0.0049 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0044 0.0048
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.018 0.0208 0.1229
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Brugia malayi nuclear receptor RXR 0.0027 0.0004 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0116 0.0123 0.0123
Schistosoma mansoni tgf-beta family 0.0033 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Abl 0.0121 0.0129 0.0129
Trypanosoma brucei beta tubulin 0.1257 0.1631 0.8382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0044 0.0044
Schistosoma mansoni amine GPCR 0.1228 0.1592 0.3243
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0049 0.0251
Echinococcus granulosus Tubulin beta 2C chain 0.1257 0.1631 0.1631
Echinococcus granulosus g protein coupled receptor 0.1228 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0044 0.0048
Loa Loa (eye worm) hypothetical protein 0.0049 0.0034 0.0037
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0044 0.0048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Plasmodium falciparum plasmepsin VI 0.0097 0.0097 0.055
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0004 0.0004
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0031 0.0009 0.001
Brugia malayi ecdysteroid receptor 0.0057 0.0044 0.0048
Onchocerca volvulus 0.1228 0.1592 0.6804
Trypanosoma brucei histone deacetylase, putative 0.022 0.0259 0.1299
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0024 0.0085
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0004 0.0005
Entamoeba histolytica hypothetical protein 0.0038 0.002 0.0072
Schistosoma mansoni opsin-like receptor 0.1228 0.1592 0.3243
Toxoplasma gondii PAN domain-containing protein 0.0286 0.0347 0.0832
Schistosoma mansoni cell polarity protein 0.0037 0.0018 0.0036
Plasmodium falciparum plasmepsin IV 0.0097 0.0097 0.055
Echinococcus granulosus dna polymerase kappa 0.0042 0.0024 0.0024
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1228 0.1592 0.3243
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0044 0.009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0044 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Schistosoma mansoni MAGUK homolog 0.0037 0.0018 0.0036
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0064 0.0054 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi brahma associated protein 60 kDa 0.018 0.0208 0.0226
Schistosoma mansoni hypothetical protein 0.0273 0.033 0.0672
Giardia lamblia Beta tubulin 0.1257 0.1631 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.018 0.0208 0.1229
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus granulosus membrane bound transcription factor site 1 0.006 0.0049 0.0049
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0004 0.0004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1228 0.1592 0.3243
Leishmania major beta tubulin 0.1257 0.1631 1
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.041 0.2474
Trichomonas vaginalis tubulin beta chain, putative 0.1257 0.1631 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1228 0.1592 0.1592
Echinococcus multilocularis serotonin receptor 0.1346 0.1749 0.1749
Brugia malayi RE15519p 0.1228 0.1592 0.173
Onchocerca volvulus 0.021 0.0246 0.1052
Echinococcus multilocularis tyrosine protein kinase HCK 0.0071 0.0063 0.0063
Onchocerca volvulus 0.0027 0.0004 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0044 0.0048
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0009 0.0009
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.018 0.0208 0.0491
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0044 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1228 0.1592 0.3243
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0014
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.006 0.0049 0.4991
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0034 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Brugia malayi hypothetical protein 0.0033 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.009 0.0088 0.0096
Echinococcus multilocularis Tubulin beta 2C chain 0.1257 0.1631 0.1631
Onchocerca volvulus Putative endochitinase 0.0075 0.0068 0.0292
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0044 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0012
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0034 0.0034
Echinococcus granulosus allatostatin A receptor 0.1793 0.2339 0.2339
Loa Loa (eye worm) TK protein kinase 0.0086 0.0083 0.009
Toxoplasma gondii beta tubulin 0.1257 0.1631 0.396
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0049 0.0251
Loa Loa (eye worm) proprotein convertase 2 0.0333 0.041 0.0445
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0044 0.0188
Schistosoma mansoni neuropeptide F-like receptor 0.1228 0.1592 0.3243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0044 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Echinococcus granulosus adam 0.003 0.0009 0.0009
Loa Loa (eye worm) TK/EPH protein kinase 0.0274 0.0331 0.0359
Toxoplasma gondii PAN domain-containing protein 0.0286 0.0347 0.0832
Echinococcus multilocularis somatostatin receptor 0.1228 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Echinococcus multilocularis 0.0106 0.0109 0.0109
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0035 0.0035
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0058 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Loa Loa (eye worm) hypothetical protein 0.0374 0.0464 0.0504
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0101 0.0103 0.0103
Schistosoma mansoni tubulin subunit beta 0.1257 0.1631 0.3323
Loa Loa (eye worm) hypothetical protein 0.0067 0.0058 0.0063
Echinococcus granulosus fibrillin 2 0.003 0.0009 0.0009
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0097 0.0097 0.055
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0273 0.033 0.1983
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0061 0.0049 0.0053
Echinococcus granulosus g-protein coupled receptor 0.1228 0.1592 0.1592
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.006 0.0049 0.1004
Brugia malayi Deoxyribonuclease II family protein 0.0073 0.0065 0.0071
Echinococcus multilocularis guanylate kinase 0.003 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.041 0.2474
Echinococcus multilocularis p2X purinoceptor 4 0.0134 0.0146 0.0146
Trypanosoma brucei calpain, putative 0.0116 0.0122 0.0591
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0101 0.0103 0.0103
Echinococcus granulosus glutamate receptor 2 0.0049 0.0034 0.0034
Schistosoma mansoni MAGUK homolog 0.0037 0.0019 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0012 0.0012
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.006 0.0049 0.0099
Echinococcus multilocularis fibrillin 1 0.0031 0.001 0.001
Echinococcus multilocularis neuropeptide FF receptor 2 0.1695 0.221 0.221
Giardia lamblia Histone deacetylase 0.0244 0.0292 0.1747
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0076 0.007 0.007
Echinococcus multilocularis allatostatin A receptor 0.1793 0.2339 0.2339
Echinococcus multilocularis Tubulin beta 2C chain 0.1257 0.1631 0.1631
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0004 0.0009
Echinococcus multilocularis nardilysin 0.0043 0.0026 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.1228 0.1592 0.1592
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0012 0.0012
Brugia malayi nuclear hormone receptor 0.0057 0.0044 0.0048
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi putative neuropeptide receptor 0.1228 0.1592 0.173
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Echinococcus granulosus integrin alpha ps 0.0068 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0006
Echinococcus granulosus ephrin type A receptor 4 A 0.0216 0.0255 0.0255
Giardia lamblia High cysteine protein 0.003 0.0009 0.0003
Brugia malayi hypothetical protein 0.003 0.0009 0.0009
Brugia malayi CXXC zinc finger family protein 0.0031 0.001 0.0011
Loa Loa (eye worm) histone deacetylase 1 0.0244 0.0292 0.0317
Entamoeba histolytica chitinase, putative 0.0075 0.0068 0.0371
Schistosoma mansoni amine GPCR 0.1228 0.1592 0.3243
Schistosoma mansoni brg-1 associated factor 0.018 0.0208 0.0423
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0004 0.0005
Trypanosoma brucei RNA helicase, putative 0.1494 0.1944 1
Echinococcus multilocularis caspase 2 0.0167 0.019 0.019
Leishmania major histone deacetylase, putative 0.022 0.0259 0.1549
Toxoplasma gondii histone deacetylase HDAC2 0.0244 0.0292 0.0696
Leishmania major chitinase 0.0075 0.0068 0.0371
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis ring and YY1 binding protein 0.0064 0.0054 0.0054
Loa Loa (eye worm) DR-78 0.0027 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0044 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Brugia malayi Guanylate kinase family protein 0.003 0.0008 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.1228 0.1592 0.1592
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0044 0.0048
Echinococcus multilocularis histone deacetylase 6 0.0226 0.0268 0.0268
Loa Loa (eye worm) SRC-1 0.0101 0.0103 0.0112
Brugia malayi sulfakinin receptor protein 0.1646 0.2145 0.2331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.002 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0068 0.006 0.0065
Brugia malayi Endochitinase 0.0075 0.0068 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0013
Echinococcus multilocularis nardilysin 0.0071 0.0063 0.0063
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.006 0.0049 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Trichomonas vaginalis hypothetical protein 0.003 0.0009 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0124 0.0717
Plasmodium vivax histone deacetylase, putative 0.022 0.0259 0.1549
Toxoplasma gondii subtilisin SUB10 0.006 0.0049 0.0104
Brugia malayi Guanylate kinase family protein 0.0037 0.0018 0.0019
Loa Loa (eye worm) integrin alpha pat-2 0.0232 0.0276 0.03
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0004 0.0004
Trypanosoma cruzi metacaspase 5, putative 0.0118 0.0124 0.0717
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Brugia malayi Peptidase family M13 containing protein 0.0091 0.009 0.0097
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0004 0.0005
Echinococcus multilocularis insulin degrading enzyme 0.0071 0.0063 0.0063
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Plasmodium falciparum tubulin beta chain 0.1257 0.1631 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0012 0.0012
Onchocerca volvulus Putative endochitinase 0.0075 0.0068 0.0292
Trichomonas vaginalis histone deacetylase, putative 0.0244 0.0292 0.1747
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0124 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Chlamydia trachomatis insulinase family protease III 0.0071 0.0063 0.2742
Brugia malayi hypothetical protein 0.0027 0.0004 0.0005
Onchocerca volvulus 0.0057 0.0044 0.0188
Echinococcus granulosus tubulin beta 4A class IVa 0.1257 0.1631 0.1631
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1594 0.2076 0.2076
Schistosoma mansoni deoxyribonuclease II-related 0.0073 0.0065 0.0133
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0064 0.0054 0.0282
Leishmania major beta tubulin 0.1257 0.1631 1
Plasmodium vivax plasmepsin IV, putative 0.0097 0.0097 0.055
Schistosoma mansoni fusion 0.0064 0.0054 0.011
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus granulosus integrin alpha ps 0.0032 0.0012 0.0012
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0116 0.0122 0.0591
Schistosoma mansoni tyrosine kinase 0.0071 0.0063 0.0128
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus granulosus neuropeptide receptor A26 0.1228 0.1592 0.1592
Schistosoma mansoni ATP-dependent RNA Helicase 0.0037 0.0018 0.0036
Echinococcus granulosus dro:myosuppressin receptor 0.1228 0.1592 0.1592
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0116 0.0122 0.0705
Brugia malayi follicle stimulating hormone receptor 0.181 0.2361 0.2566
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Trypanosoma brucei metacaspase MCA2 0.0118 0.0124 0.0601
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0049 0.0251
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0024 0.0405
Onchocerca volvulus 0.0027 0.0004 0.0019
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0038
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0101 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.021 0.0246 0.0267
Leishmania major beta tubulin 0.1257 0.1631 1
Loa Loa (eye worm) POT family protein 0.0039 0.0021 0.0023
Leishmania major metacaspase, putative 0.0118 0.0124 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0809 0.1039 0.6352
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1228 0.1592 0.173
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.003 0.0008 0.0009
Brugia malayi beta-tubulin, identical 0.1257 0.1631 0.1772
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Schistosoma mansoni biogenic amine (5HT) receptor 0.1594 0.2076 0.4231
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0197 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Schistosoma mansoni tyrosine kinase 0.016 0.018 0.0367
Schistosoma mansoni histone deacetylase 0.0244 0.0292 0.0594
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1228 0.1592 0.3243
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.006 0.0049 0.1004
Loa Loa (eye worm) matrix metalloproteinase 0.005 0.0035 0.0038
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0004 0.0005
Echinococcus multilocularis SWI:SNF matrix associated 0.018 0.0208 0.0208
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.006 0.0049 0.1004
Echinococcus multilocularis histone deacetylase 3 0.0244 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0064 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0374 0.0464 0.0504
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0226 0.1343
Loa Loa (eye worm) hypothetical protein 0.0067 0.0058 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0044 0.0048
Schistosoma mansoni biogenic amine receptor 0.1228 0.1592 0.3243
Echinococcus granulosus tumor protein p63 0.0334 0.041 0.041
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Brugia malayi Melatonin receptor type 1A 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0016 0.0018
Loa Loa (eye worm) LjBmp2/4b 0.0033 0.0012 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0009 0.0018
Echinococcus granulosus histone deacetylase 0.022 0.0259 0.0259
Plasmodium vivax subtilisin-like serine protease, putative 0.006 0.0049 0.0251
Loa Loa (eye worm) beta-tubulin 0.1257 0.1631 0.1772
Brugia malayi Protein kinase domain containing protein 0.0027 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi polk-prov protein 0.0032 0.0011 0.0012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0024 0.0101
Echinococcus granulosus hypothetical protein 0.1228 0.1592 0.1592
Echinococcus granulosus glutamate receptor subunit protein glur 0.0033 0.0012 0.0012
Echinococcus granulosus 3'partial|nardilysin 0.0071 0.0063 0.0063
Brugia malayi Histone deacetylase family protein 0.022 0.0259 0.0282
Schistosoma mansoni zinc finger protein 0.0064 0.0054 0.011
Toxoplasma gondii peptidase family M13 protein 0.0091 0.009 0.0204
Schistosoma mansoni hypothetical protein 0.1494 0.1944 0.3961
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0209 0.1238
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.003 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.006 0.0049 0.1004
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.0022 0.0022
Mycobacterium ulcerans chitinase/cellulase 0.0064 0.0054 0.1125
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.7589 1 1
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus multilocularis p2X purinoceptor 4 0.0134 0.0146 0.0146
Trypanosoma brucei calpain-like protein, putative 0.0116 0.0122 0.0591
Echinococcus granulosus 5'partial|nardilysin 0.0031 0.0011 0.0011
Echinococcus granulosus zinc finger protein Ran binding 0.0064 0.0054 0.0054
Loa Loa (eye worm) histone deacetylase 11 0.0105 0.0108 0.0117
Trypanosoma cruzi WLM domain containing protein, putative 0.0064 0.0054 0.0282
Brugia malayi Shank2E 0.0024 0.0001 0.0001
Echinococcus granulosus glutamate NMDA receptor subunit 0.0276 0.0333 0.0333
Onchocerca volvulus Slit protein homolog 0.0025 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Loa Loa (eye worm) TK/ALK protein kinase 0.0032 0.0012 0.0013
Echinococcus multilocularis NCK adaptor protein 0.0031 0.0009 0.0009
Toxoplasma gondii aspartyl protease ASP1 0.0097 0.0097 0.0222
Brugia malayi G protein-coupled receptor F59B2.13 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi larval opioid receptor 0.1228 0.1592 0.173
Echinococcus granulosus guanylate kinase 0.003 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0024 0.0101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.002 0.002
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0116 0.0122 0.0705
Plasmodium falciparum metacaspase 1 0.0118 0.0124 0.0717
Onchocerca volvulus Histone deacetylase 10 homolog 0.0105 0.0108 0.046
Brugia malayi map kinase activated protein kinase protein 2 0.0197 0.0229 0.0249
Loa Loa (eye worm) hypothetical protein 0.1646 0.2145 0.2331
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0012 0.0025
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.003 0.0061
Echinococcus multilocularis high voltage activated calcium channel beta 0.003 0.0008 0.0008
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0072 0.0064 0.0291
Toxoplasma gondii subtilisin SUB5 0.006 0.0049 0.0104
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.006 0.0049 0.4991
Echinococcus multilocularis slit 2 protein 0.0025 0.0002 0.0002
Echinococcus granulosus peptide allatostatin:somatostatin 0.1228 0.1592 0.1592
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0064 0.0054 0.023
Echinococcus granulosus deoxyribonuclease ii 0.0073 0.0065 0.0065
Schistosoma mansoni cathepsin D (A01 family) 0.0286 0.0347 0.0707
Brugia malayi Glutamate receptor 2 precursor 0.0033 0.0012 0.0013
Echinococcus multilocularis epidermal growth factor receptor 0.016 0.018 0.018
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0084 0.008 0.1767
Echinococcus multilocularis caspase 3 0.0176 0.0201 0.0201
Echinococcus granulosus neuroendocrine convertase 2 0.0836 0.1074 0.1074
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus multilocularis 0.1039 0.1342 0.1342
Brugia malayi EGF-like domain containing protein 0.003 0.0009 0.0009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1228 0.1592 0.1592
Leishmania major beta tubulin 0.1257 0.1631 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0058 0.0063
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0101 0.0103 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0057 0.0044 0.0044
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0033 0.0012 0.0012
Leishmania major beta tubulin 0.1257 0.1631 1
Brugia malayi hypothetical protein 0.005 0.0035 0.0038
Entamoeba histolytica tubulin family protein 0.1257 0.1631 1
Leishmania major beta tubulin 0.1257 0.1631 1
Echinococcus multilocularis serotonin receptor 0.1346 0.1749 0.1749
Brugia malayi histone deacetylase 11 0.0105 0.0108 0.0117
Echinococcus granulosus Tubulin beta 2C chain 0.1257 0.1631 0.1631
Schistosoma mansoni neuropeptide F-like receptor 0.1228 0.1592 0.3243
Schistosoma mansoni nuclear receptor 0.0027 0.0004 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus granulosus tm gpcr rhodopsin 0.1228 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus multilocularis segment polarity protein dishevelled 0.0103 0.0106 0.0106
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1228 0.1592 0.1592
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Echinococcus granulosus segment polarity protein dishevelled 0.0103 0.0106 0.0106
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1228 0.1592 0.173
Echinococcus multilocularis tubulin beta 1 chain 0.1257 0.1631 0.1631
Brugia malayi Histone deacetylase family protein 0.022 0.0259 0.0282
Loa Loa (eye worm) hypothetical protein 0.1793 0.2339 0.2542
Echinococcus granulosus neuropeptide receptor 0.1538 0.2002 0.2002
Trichomonas vaginalis tubulin epsilon chain, putative 0.1257 0.1631 1
Echinococcus multilocularis nardilysin 0.0071 0.0063 0.0063
Loa Loa (eye worm) subtilase 0.006 0.0049 0.0053
Echinococcus granulosus tyrosine protein kinase Src64B 0.0101 0.0103 0.0103
Plasmodium falciparum subtilisin-like protease 3 0.006 0.0049 0.0251
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0194 0.0226 0.537
Brugia malayi hypothetical protein 0.0197 0.0229 0.0249
Schistosoma mansoni histone deacetylase 0.0244 0.0292 0.0594
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0059
Brugia malayi putative neuropeptide receptor NPR1 0.1228 0.1592 0.173
Schistosoma mansoni insulysin (M16 family) 0.0039 0.0021 0.0043
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0073 0.0065 0.0071
Brugia malayi YY1-associated factor 2 0.0064 0.0054 0.0059
Brugia malayi Sex muscle abnormal protein 5 0.0031 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.018 0.0208 0.0423
Onchocerca volvulus 0.0026 0.0003 0.0013
Trypanosoma brucei metacaspase MCA3 0.0118 0.0124 0.0601
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0025
Trypanosoma cruzi subtilisin peptidase 0.006 0.0049 0.0251
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0116 0.0122 0.0705
Giardia lamblia Tenascin precursor 0.003 0.0009 0.0003
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0282
Toxoplasma gondii ran binding protein 0.0064 0.0054 0.0117
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Onchocerca volvulus Putative endochitinase 0.0075 0.0068 0.0292
Brugia malayi Transforming growth factor beta like domain containing protein 0.0033 0.0012 0.0013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0101 0.0103 0.0103
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.012 0.013
Loa Loa (eye worm) histone deacetylase 3 0.0244 0.0292 0.0317
Trypanosoma brucei C-8 sterol isomerase, putative 0.0374 0.0464 0.2353
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.0034 0.0037
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Toxoplasma gondii guanylate kinase family protein 0.003 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Plasmodium falciparum histone deacetylase, putative 0.022 0.0259 0.1549
Mycobacterium ulcerans epoxide hydrolase EphA 0.0336 0.0414 1
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.033 0.1983
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Leishmania major histone deacetylase, putative 0.0244 0.0292 0.1747
Schistosoma mansoni adenoreceptor 0.1228 0.1592 0.3243
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi AKH receptor 0.1228 0.1592 0.173
Schistosoma mansoni nck2/grb4 0.0031 0.0009 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0004 0.0009
Schistosoma mansoni growth hormone secretagogue receptor 0.1228 0.1592 0.3243
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0282
Chlamydia trachomatis DNA topoisomerase I 0.018 0.0208 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Brugia malayi SH2 domain containing protein 0.0056 0.0043 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.009 0.0097
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Giardia lamblia Neurogenic locus notch-like protein 0.003 0.0009 0.0003
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus tyrosine protein kinase ABL1 0.0241 0.0287 0.0287
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0101 0.0103 0.0103
Schistosoma mansoni adapter molecule crk 0.0031 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0017
Schistosoma mansoni tyrosine kinase 0.0225 0.0267 0.0544
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.0066
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus granulosus nardilysin 0.0071 0.0063 0.0063
Onchocerca volvulus Putative endochitinase 0.0075 0.0068 0.0292
Echinococcus granulosus tyrosine protein kinase csk 0.004 0.0022 0.0022
Echinococcus granulosus histone deacetylase 3 0.0244 0.0292 0.0292
Echinococcus granulosus beta tubulin 0.1257 0.1631 0.1631
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi G-protein coupled receptor 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.1346 0.1749 0.19
Schistosoma mansoni hypothetical protein 0.0139 0.0153 0.0312
Loa Loa (eye worm) tubulin beta-4 chain 0.1257 0.1631 0.1772
Toxoplasma gondii subtilisin SUB2 0.006 0.0049 0.0104
Brugia malayi ZU5 domain containing protein 0.003 0.0008 0.0009
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0273 0.033 0.1983
Schistosoma mansoni integrin beta subunit 0.0751 0.0962 0.1961
Onchocerca volvulus 0.1228 0.1592 0.6804
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0054 0.0237
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0071 0.0063 0.0128
Brugia malayi Protein kinase domain containing protein 0.0032 0.0012 0.0013
Schistosoma mansoni integrin alpha-ps 0.0035 0.0016 0.0032
Leishmania major hypothetical protein, unknown function 0.0056 0.0043 0.0215
Plasmodium vivax metacaspase 1, putative 0.0118 0.0124 0.0717
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Schistosoma mansoni neuropeptide receptor 0.1228 0.1592 0.3243
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0044 0.0044
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0004 0.0019
Brugia malayi insulin-degrading enzyme 0.0071 0.0063 0.0068
Schistosoma mansoni RNA binding protein 0.0064 0.0054 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0124 0.0717
Trichomonas vaginalis histone deacetylase, putative 0.0244 0.0292 0.1747
Brugia malayi Steroid receptor seven-up type 2 0.0057 0.0044 0.0048
Echinococcus multilocularis integrin alpha 3 0.0116 0.0122 0.0122
Echinococcus multilocularis MAGUK p55 subfamily 0.0037 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0025
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0004 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0044 0.009
Echinococcus multilocularis neuropeptide Y receptor 0.1228 0.1592 0.1592
Echinococcus granulosus disks large 3 0.0037 0.0018 0.0018
Trichomonas vaginalis tubulin, putative 0.1257 0.1631 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0293 0.0357 0.0357
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0071 0.0063 0.0138
Brugia malayi steroid hormone receptor 0.0057 0.0044 0.0048
Loa Loa (eye worm) TK protein kinase 0.0071 0.0063 0.0068
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.0066
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.6985 0.9202 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0316 0.1897
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0097 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.0066
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0072 0.0064 0.0348
Brugia malayi PDZ domain containing protein 0.0078 0.0072 0.0079
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis beta tubulin 0.1257 0.1631 0.1631
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0591
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0004 0.0005
Echinococcus granulosus Tubulin beta 2C chain 0.1257 0.1631 0.1631
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Echinococcus multilocularis histone deacetylase 6 0.022 0.0259 0.0259
Echinococcus granulosus Upstream activation factor subunit UAF30 0.018 0.0208 0.0208
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1312 0.1703 0.347
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1228 0.1592 0.3243
Loa Loa (eye worm) hypothetical protein 0.0078 0.0072 0.0079
Plasmodium vivax histone deacetylase 2, putative 0.022 0.0259 0.1549
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0076 0.007 0.0143
Loa Loa (eye worm) bone morphogenic protein 6 0.0128 0.0138 0.015
Plasmodium falciparum plasmepsin I 0.0097 0.0097 0.055
Echinococcus multilocularis p2X purinoceptor 4 0.0134 0.0146 0.0146
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Echinococcus granulosus histone deacetylase 6 0.022 0.0259 0.0259
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0106 0.0109 0.0222
Schistosoma mansoni ephrin receptor 0.0216 0.0255 0.0519
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.003 0.0008 0.0016
Onchocerca volvulus 0.1228 0.1592 0.6804
Schistosoma mansoni P2X receptor subunit 0.0134 0.0146 0.0297
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0139 0.0153 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.1228 0.1592 0.1592
Echinococcus multilocularis histone deacetylase 6 0.022 0.0259 0.0259
Toxoplasma gondii histone deacetylase HDAC1 0.022 0.0259 0.0618
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0064 0.0054 0.0282
Schistosoma mansoni histone deacetylase hda2 0.0105 0.0108 0.0219
Echinococcus multilocularis tyrosine protein kinase Src42A 0.008 0.0074 0.0074
Brugia malayi tailless protein 0.0027 0.0004 0.0005
Trypanosoma brucei histone deacetylase 3 0.022 0.0259 0.1299
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0282
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.0316 0.0343
Entamoeba histolytica histone deacetylase, putative 0.0244 0.0292 0.1747
Onchocerca volvulus 0.1228 0.1592 0.6804
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0084 0.008 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.0022 0.0022
Echinococcus granulosus epidermal growth factor receptor 0.016 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0502 0.0633 0.0688
Echinococcus granulosus Tubulin beta 2C chain 0.1257 0.1631 0.1631
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0004 0.0005
Schistosoma mansoni caspase-7 (C14 family) 0.0167 0.019 0.0388
Loa Loa (eye worm) hypothetical protein 0.0121 0.0129 0.014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0044 0.0048
Giardia lamblia High cysteine protein 0.003 0.0009 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Schistosoma mansoni amine GPCR 0.1228 0.1592 0.3243
Echinococcus granulosus p2X purinoceptor 4 0.0134 0.0146 0.0146
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0031 0.0009 0.0019
Echinococcus granulosus dnaJ subfamily B 0.1785 0.2329 0.2329
Echinococcus granulosus caspase 3 0.0176 0.0201 0.0201
Schistosoma mansoni myosin xvIII 0.1228 0.1592 0.3243
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1228 0.1592 0.1592
Toxoplasma gondii insulysin, putative 0.0067 0.0058 0.0127
Trypanosoma cruzi histone deacetylase, putative 0.0105 0.0108 0.0614
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0054 0.0059
Echinococcus multilocularis integrin beta 2 0.0948 0.1223 0.1223
Giardia lamblia Tenascin-X 0.003 0.0009 0.0003
Loa Loa (eye worm) matrixin family protein 0.008 0.0075 0.0081
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.006 0.0049 0.0251
Trypanosoma cruzi histone deacetylase, putative 0.022 0.0259 0.1549
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0208 0.1229
Leishmania major beta tubulin 0.1257 0.1631 1
Giardia lamblia hypothetical protein 0.003 0.0009 0.0003
Brugia malayi Dopamine receptor protein 1 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0191 0.0222 0.0241
Schistosoma mansoni dishevelled 0.0093 0.0092 0.0188
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.018 0.0208 0.0491
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.009 1
Trypanosoma cruzi metacaspase, putative 0.0118 0.0124 0.0717
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0038
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0058 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0056 0.0115
Schistosoma mansoni serine-type protease inhibitor 0.1807 0.2358 0.4804
Echinococcus multilocularis ephrin type A receptor 4 A 0.0216 0.0255 0.0255
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0336 0.0414 1
Schistosoma mansoni hypothetical protein 0.018 0.0208 0.0423
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Echinococcus multilocularis guanylate kinase 0.003 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Brugia malayi nuclear receptor RXR 0.003 0.0009 0.0009
Onchocerca volvulus 0.0049 0.0034 0.0144
Entamoeba histolytica tubulin family protein 0.1257 0.1631 1
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0282
Leishmania major beta tubulin 0.1257 0.1631 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0097 0.0097 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0011 0.0015
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.018 0.0208 0.0208
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0097 0.0097 0.0106
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1228 0.1592 0.173
Echinococcus granulosus MAM 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0009
Toxoplasma gondii subtilisin SUB1 0.006 0.0049 0.0104
Schistosoma mansoni hypothetical protein 0.1785 0.2329 0.4745
Schistosoma mansoni hypothetical protein 0.0032 0.0012 0.0024
Echinococcus granulosus somatostatin receptor 0.1228 0.1592 0.1592
Toxoplasma gondii subtilisin SUB12 0.0079 0.0073 0.0163
Echinococcus multilocularis orexin receptor type 2 0.1228 0.1592 0.1592
Schistosoma mansoni hypothetical protein 0.0139 0.0153 0.0312
Trypanosoma brucei beta tubulin 0.1257 0.1631 0.8382
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Onchocerca volvulus 0.0064 0.0054 0.023
Schistosoma mansoni histone deacetylase hda2 0.0226 0.0268 0.0546
Loa Loa (eye worm) guanylate kinase 0.0037 0.0018 0.0019
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0001
Echinococcus granulosus nmda type glutamate receptor 0.0116 0.0123 0.0123
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1228 0.1592 0.1592
Echinococcus granulosus Tubulin beta 2C chain 0.1257 0.1631 0.1631
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus granulosus tubulin subunit beta 0.1257 0.1631 0.1631
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1793 0.2339 0.4767
Echinococcus multilocularis protein jagged 2 0.003 0.0009 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Onchocerca volvulus Matrilysin homolog 0.005 0.0035 0.0149
Loa Loa (eye worm) hypothetical protein 0.1312 0.1703 0.1851
Echinococcus multilocularis cpg binding protein 0.0033 0.0013 0.0013
Brugia malayi guanylate kinase 0.003 0.0008 0.0009
Trichomonas vaginalis DNAse2-prov protein, putative 0.0073 0.0065 0.0353
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0043 0.0215
Trichomonas vaginalis histone deacetylase, putative 0.0244 0.0292 0.1747
Echinococcus granulosus tyrosine protein kinase Fyn 0.0101 0.0103 0.0103
Echinococcus multilocularis caspase 0.0293 0.0357 0.0357
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0064 0.0054 0.0237
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0101 0.0103 0.0103
Leishmania major beta tubulin 0.1257 0.1631 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.0066
Schistosoma mansoni cpg binding protein 0.0033 0.0013 0.0025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0044 0.0044
Echinococcus granulosus orexin receptor type 2 0.1228 0.1592 0.1592
Loa Loa (eye worm) TK/CSK protein kinase 0.004 0.0022 0.0024
Brugia malayi Matrixin family protein 0.008 0.0075 0.0081
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0106 0.0109 0.0109
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.003 0.0008 0.0016
Chlamydia trachomatis glutamine binding protein 0.0084 0.008 0.3594
Onchocerca volvulus 0.1793 0.2339 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.041 0.2474
Brugia malayi ORL1-like opioid receptor 0.1228 0.1592 0.173
Echinococcus multilocularis tgf beta family 0.0033 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0044 0.0044
Leishmania major phosphoinositide phosphatase 0.0194 0.0226 0.1343
Brugia malayi endochitinase 0.0075 0.0068 0.0074
Echinococcus multilocularis integrin alpha ps 0.0068 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi histone deacetylase 3 (HD3) 0.0244 0.0292 0.0317
Echinococcus multilocularis histone deacetylase 0.022 0.0259 0.0259
Trichomonas vaginalis tubulin alpha chain, putative 0.1257 0.1631 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.003 0.0061
Brugia malayi EGF-like domain containing protein 0.0025 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.0018 0.0018
Brugia malayi Transforming growth factor beta like domain containing protein 0.0128 0.0138 0.015
Entamoeba histolytica hypothetical protein 0.0038 0.002 0.0072
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0118 0.0124 0.0288
Echinococcus multilocularis MAGUK p55 subfamily 0.0037 0.0018 0.0018
Trypanosoma brucei histone deacetylase 4 0.022 0.0259 0.1299
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.0091 0.009 0.0097
Echinococcus granulosus tyrosine protein kinase csk 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0044 0.009
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.014 0.0155 0.0155
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Entamoeba histolytica hypothetical protein 0.0038 0.002 0.0072
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0076 0.007 0.007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1228 0.1592 0.3243
Onchocerca volvulus 0.003 0.0009 0.0038
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0073 0.0065 0.0071
Schistosoma mansoni nardilysin (M16 family) 0.0071 0.0063 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Trichomonas vaginalis histone deacetylase, putative 0.0244 0.0292 0.1747
Onchocerca volvulus 0.0064 0.0054 0.023
Onchocerca volvulus 0.0045 0.0029 0.0123
Brugia malayi Dopamine receptor protein 2 0.1228 0.1592 0.173
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1228 0.1592 0.3243
Schistosoma mansoni cell polarity protein 0.0045 0.0028 0.0057
Brugia malayi ecdysone receptor 0.0027 0.0004 0.0005
Toxoplasma gondii toxolysin TLN4 0.0031 0.0011 0.0011
Plasmodium falciparum histone deacetylase 2 0.022 0.0259 0.1549
Plasmodium falciparum subtilisin-like protease 2 0.006 0.0049 0.0251
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.005 0.0035 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0034 0.0034
Trypanosoma brucei histone deacetylase 1 0.0244 0.0292 0.1465
Schistosoma mansoni hypothetical protein 0.018 0.0208 0.0423
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.018 0.0208 0.0226
Schistosoma mansoni caspase-7 (C14 family) 0.0293 0.0357 0.0727
Loa Loa (eye worm) microfilarial chitinase 0.0064 0.0054 0.0058
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0809 0.1039 0.1039
Echinococcus granulosus G protein coupled receptor 139 0.1228 0.1592 0.1592
Schistosoma mansoni septate junction protein 0.003 0.0008 0.0017
Toxoplasma gondii beta-1 tubulin, putative 0.1257 0.1631 0.396
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0316 0.1897
Echinococcus multilocularis Tubulin beta 2C chain 0.1257 0.1631 0.1631
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0139 0.0153 0.0166
Echinococcus multilocularis MAM 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0049 0.0053
Echinococcus granulosus biogenic amine 5HT receptor 0.1346 0.1749 0.1749
Echinococcus multilocularis SWI:SNF matrix associated 0.018 0.0208 0.0208
Brugia malayi hypothetical protein 0.0033 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.009 0.0097
Schistosoma mansoni cpg binding protein 0.0033 0.0013 0.0025
Trypanosoma cruzi beta tubulin, putative 0.1257 0.1631 1
Echinococcus granulosus guanylate kinase 0.003 0.0008 0.0008
Schistosoma mansoni histone deacetylase 1 2 3 0.0105 0.0108 0.0219
Toxoplasma gondii subtilisin SUB4 0.006 0.0049 0.0104
Mycobacterium leprae Possible secreted protease 0.006 0.0049 0.4991
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0037 0.0019 0.0019
Loa Loa (eye worm) growth/differentiation factor 10 0.0033 0.0012 0.0013
Echinococcus multilocularis segment polarity protein dishevelled 0.0103 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0809 0.1039 0.6352
Trypanosoma cruzi peptidase, putative 0.0071 0.0063 0.0337
Giardia lamblia Tenascin-37 0.003 0.0009 0.0003
Echinococcus granulosus fibrillin 1 0.0031 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1228 0.1592 0.3243
Echinococcus granulosus tyrosine protein kinase Fyn 0.0101 0.0103 0.0103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0012 0.0014
Onchocerca volvulus 0.0027 0.0004 0.0019
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0241 0.0287 0.0287
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0044 0.009
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0128 0.0138 0.0138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0024 0.0101
Loa Loa (eye worm) hypothetical protein 0.1346 0.1749 0.19
Loa Loa (eye worm) tubulin beta-1 chain 0.1257 0.1631 0.1772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0044 0.0048
Schistosoma mansoni hypothetical protein 0.0064 0.0054 0.011
Echinococcus granulosus chromobox protein 2 0.0202 0.0236 0.0236
Brugia malayi brahma associated protein 60 kDa 0.018 0.0208 0.0226
Echinococcus multilocularis chromobox protein 2 0.0202 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0139 0.0153 0.0166
Echinococcus granulosus histone deacetylase 8 0.0105 0.0108 0.0108
Trypanosoma brucei beta tubulin 0.1257 0.1631 0.8382
Echinococcus granulosus Zinc finger RanBP2 type 0.0064 0.0054 0.0054
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0071 0.0063 0.0337
Echinococcus granulosus histone deacetylase 6 0.0226 0.0268 0.0268
Leishmania major beta tubulin 0.1257 0.1631 1
Onchocerca volvulus 0.0031 0.001 0.0043
Brugia malayi Matrixin family protein 0.005 0.0035 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.041 0.2474
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0064 0.0054 0.0282
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.0018 0.0037
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1228 0.1592 0.1592
Brugia malayi SWIB/MDM2 domain containing protein 0.018 0.0208 0.0226
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0012 0.0025
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0025
Brugia malayi nuclear hormone receptor 0.0027 0.0004 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0001
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0116 0.0122 0.0705
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.3736 0.4907 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0086 0.0083 0.0083
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0795 0.102 0.102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0012 0.0014
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0084 0.008 0.1767
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0124 0.0717
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0001
Echinococcus multilocularis dro:myosuppressin receptor 0.1228 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Leishmania major histone deacetylase, putative 0.022 0.0259 0.1549
Onchocerca volvulus Matrilysin homolog 0.011 0.0115 0.0491
Echinococcus multilocularis neuropeptides capa receptor 0.1228 0.1592 0.1592
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0044 0.0044
Onchocerca volvulus Putative endochitinase 0.0075 0.0068 0.0292
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0705
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0012 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0004 0.0004
Brugia malayi conserved hypotetical protein 0.0027 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0059
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0044 0.0048
Brugia malayi EGF-like domain containing protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0059
Echinococcus granulosus tyrosine kinase 0.0086 0.0083 0.0083
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0705
Schistosoma mansoni histone deacetylase 4 5 0.022 0.0259 0.0529
Schistosoma mansoni amine GPCR 0.1228 0.1592 0.3243
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0044 0.0048
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus slit 2 protein 0.0025 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0024 0.0101
Echinococcus granulosus bone morphogenetic protein 2 0.0033 0.0012 0.0012
Brugia malayi celfurPC protein 0.1039 0.1342 0.1459
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0071 0.0063 0.0128
Brugia malayi protein-tyrosine kinase 0.0086 0.0083 0.009
Loa Loa (eye worm) BEN-1 protein 0.1257 0.1631 0.1772
Plasmodium vivax subtilisin-like protease 1 0.006 0.0049 0.0251
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0316 0.1897
Loa Loa (eye worm) histone deacetylase 0.022 0.0259 0.0282
Trypanosoma cruzi histone deacetylase 1, putative 0.0244 0.0292 0.1747
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0004 0.0019
Brugia malayi Cell death protein 3 precursor 0.0167 0.019 0.0207
Loa Loa (eye worm) hypothetical protein 0.0091 0.009 0.0097
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0679 0.0867 0.1767
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis neuroendocrine convertase 2 0.0836 0.1074 0.1074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0013
Plasmodium vivax histone deacetylase 1, putative 0.0244 0.0292 0.1747
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0044 0.0048
Schistosoma mansoni mannosidase endo-alpha 0.003 0.0008 0.0016
Echinococcus granulosus MAGUK p55 subfamily 0.0037 0.0018 0.0018
Brugia malayi Serotonin receptor 0.1676 0.2184 0.2373
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0057 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0044 0.0048
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0009 0.001
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0139 0.0153 0.0153
Loa Loa (eye worm) integrin beta-2 0.1284 0.1667 0.1811
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0037 0.0018 0.0018
Onchocerca volvulus 0.005 0.0035 0.0149
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0044 0.0048
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.006 0.0049 0.0053
Brugia malayi G protein-coupled receptor 0.1228 0.1592 0.173
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0012 0.0025
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1228 0.1592 0.1592
Trypanosoma cruzi histone deacetylase, putative 0.0105 0.0108 0.0614
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Entamoeba histolytica hypothetical protein 0.0038 0.002 0.0072
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0036 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.148 0.1925 0.2092
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0591
Loa Loa (eye worm) neuropeptide F receptor 0.1228 0.1592 0.173
Schistosoma mansoni neuropeptide receptor 0.1228 0.1592 0.3243
Echinococcus multilocularis tubulin subunit beta 0.1257 0.1631 0.1631
Brugia malayi GnHR receptor homolog 0.17 0.2216 0.2408
Trichomonas vaginalis histone deacetylase, putative 0.0244 0.0292 0.1747
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0009 0.0018
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.0316 0.0343
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0068 0.006 0.0065
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0037 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0105 0.0108 0.0117
Echinococcus granulosus tyrosine protein kinase Src42A 0.0101 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0031
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.3132 0.4109 1
Echinococcus multilocularis SWI:SNF matrix associated 0.018 0.0208 0.0208
Schistosoma mansoni integrin alpha 0.0151 0.0168 0.0343
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0004 0.0004
Schistosoma mansoni tubulin subunit beta 0.1257 0.1631 0.3323
Loa Loa (eye worm) hypothetical protein 0.0107 0.011 0.012
Echinococcus multilocularis g-protein coupled receptor 0.1228 0.1592 0.1592
Brugia malayi Calcitonin receptor-like protein seb-1 0.0068 0.006 0.0065
Echinococcus multilocularis adam 0.003 0.0009 0.0009
Echinococcus multilocularis g protein coupled receptor 0.1228 0.1592 0.1592
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0591
Schistosoma mansoni biogenic amine receptor 0.1228 0.1592 0.3243
Leishmania major beta tubulin 0.1257 0.1631 1
Onchocerca volvulus 0.0033 0.0012 0.0053
Trypanosoma cruzi histone deacetylase 1, putative 0.0244 0.0292 0.1747
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0038
Brugia malayi hypothetical protein 0.0038 0.002 0.0021
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1228 0.1592 0.3243
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1228 0.1592 0.1592
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0084 0.008 0.3594
Mycobacterium ulcerans hydrolase 0.0061 0.0049 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0124 0.0717
Mycobacterium ulcerans chitinase/cellulase 0.0064 0.0054 0.1125
Schistosoma mansoni tubulin subunit beta 0.1257 0.1631 0.3323
Loa Loa (eye worm) chitinase I 0.0075 0.0068 0.0074
Schistosoma mansoni neuropeptide receptor 0.1538 0.2002 0.4079
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0044 0.0048
Schistosoma mansoni caspase-3 (C14 family) 0.0293 0.0357 0.0727
Toxoplasma gondii subtilisin SUB8 0.006 0.0049 0.0104
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0054 0.0059
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0116 0.0122 0.0705
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0059
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1228 0.1592 0.3243
Mycobacterium tuberculosis Possible chitinase 0.0064 0.0054 0.1125
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1257 0.1631 0.1631
Schistosoma mansoni cathepsin D (A01 family) 0.0286 0.0347 0.0707
Schistosoma mansoni TRABID protein (C64 family) 0.0064 0.0054 0.011
Schistosoma mansoni tyrosine kinase 0.0101 0.0103 0.021
Schistosoma mansoni hypothetical protein 0.1228 0.1592 0.3243
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0064 0.0054 0.0282
Brugia malayi G-protein coupled receptor 0.1228 0.1592 0.173
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0012 0.0025
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.006 0.0049 0.1004
Echinococcus granulosus c src tyrosine kinase 0.0071 0.0063 0.0063
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.003 0.0061
Onchocerca volvulus 0.1228 0.1592 0.6804
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0333 0.041 0.0835
Brugia malayi Kelch motif family protein 0.0209 0.0245 0.0266
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0044 0.009
Schistosoma mansoni tgf-beta family 0.0033 0.0012 0.0025
Giardia lamblia High cysteine membrane protein Group 2 0.0476 0.0598 0.3638
Schistosoma mansoni coup transcription factor 0.0057 0.0044 0.009
Schistosoma mansoni dishevelled 0.0103 0.0106 0.0215
Brugia malayi photoreceptor-specific nuclear receptor 0.0057 0.0044 0.0048
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0034 0.0034
Echinococcus multilocularis Tubulin beta 2C chain 0.1257 0.1631 0.1631
Echinococcus granulosus serotonin receptor 0.1228 0.1592 0.1592
Echinococcus granulosus high voltage activated calcium channel beta 0.003 0.0008 0.0008
Schistosoma mansoni opsin-like receptor 0.1228 0.1592 0.3243
Echinococcus multilocularis fmrfamide receptor 0.1228 0.1592 0.1592
Onchocerca volvulus 0.0064 0.0054 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0282
Leishmania major beta tubulin 0.1257 0.1631 1
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.006 0.0049 0.1004
Leishmania major histone deacetylase, putative 0.0244 0.0292 0.1747
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0013
Schistosoma mansoni tyrosine kinase 0.0037 0.0018 0.0037
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0103 0.0106 0.0115
Loa Loa (eye worm) DIX domain-containing protein 0.0025 0.0002 0.0002
Echinococcus multilocularis growth factor receptor bound protein 2 0.0031 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Trichomonas vaginalis deoxyribonuclease II precursor, putative 0.0073 0.0065 0.0353
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2034 0.2658 0.2658
Echinococcus granulosus neuropeptide receptor 0.1228 0.1592 0.1592
Trypanosoma cruzi metacaspase 5, putative 0.0118 0.0124 0.0717
Echinococcus multilocularis beta tubulin 0.1257 0.1631 0.1631
Loa Loa (eye worm) insulin-degrading enzyme 0.0071 0.0063 0.0068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1228 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.0118 0.0124 0.0135
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Leishmania major beta tubulin 0.1257 0.1631 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.041 0.2474
Brugia malayi Transforming growth factor beta like domain containing protein 0.0033 0.0012 0.0013
Echinococcus granulosus cpg binding protein 0.0033 0.0013 0.0013
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0118 0.0124 0.0288
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0036 0.0017 0.0034
Schistosoma mansoni biogenic amine receptor 0.1228 0.1592 0.3243
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0101 0.0103 0.0103
Schistosoma mansoni amine GPCR 0.1228 0.1592 0.3243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0097 0.0097 0.0097
Onchocerca volvulus 0.0064 0.0054 0.023
Echinococcus granulosus p2X purinoceptor 4 0.0134 0.0146 0.0146
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.0083 0.0083
Chlamydia trachomatis SWIB complex protein 0.018 0.0208 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0061 0.0049 0.5028
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1228 0.1592 0.1592
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0037 0.0018 0.0019
Echinococcus multilocularis neuropeptide receptor 0.1228 0.1592 0.1592
Schistosoma mansoni glutamate receptor NMDA 0.0276 0.0333 0.0679
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1228 0.1592 0.173
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0101 0.0103 0.0103
Schistosoma mansoni site-1 peptidase (S08 family) 0.006 0.0049 0.0099
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0064 0.0054 0.0282
Trypanosoma brucei unspecified product 0.0035 0.0016 0.0039
Echinococcus multilocularis histone deacetylase 8 0.0105 0.0108 0.0108
Echinococcus multilocularis tumor protein p63 0.0334 0.041 0.041
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0244 0.0292 0.1747
Brugia malayi Integrin beta pat-3 precursor 0.1284 0.1667 0.1811
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0374 0.0464 0.2808
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1228 0.1592 0.1592
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0072 0.0064 0.0348
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0004 0.0009
Onchocerca volvulus 0.006 0.0049 0.0209
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0118 0.0124 0.0135
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0044 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.2034 0.2658 0.2658
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0293 0.0357 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Echinococcus multilocularis caspase 8 0.0118 0.0124 0.0124
Trypanosoma cruzi metacaspase, putative 0.0118 0.0124 0.0717
Brugia malayi Dopamine receptor 0.1228 0.1592 0.173
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.009 0.0183
Brugia malayi hypothetical protein 0.003 0.0008 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.1228 0.1592 0.1592
Schistosoma mansoni integrin alpha-ps 0.0068 0.0058 0.0119
Brugia malayi Tachykinin-like peptides receptor 99D 0.1695 0.221 0.2401
Plasmodium falciparum subtilisin-like protease 1 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1228 0.1592 0.3243
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0084 0.008 0.5
Echinococcus granulosus MAGUK p55 subfamily 0.0037 0.0018 0.0018
Trichomonas vaginalis tubulin epsilon chain, putative 0.1257 0.1631 1
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.0022 0.0022
Echinococcus granulosus 7TM GPCR rhodopsin 0.1228 0.1592 0.1592
Brugia malayi histone deacetylase 1 (HD1) 0.0244 0.0292 0.0317
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.003 0.0061
Toxoplasma gondii subtilisin SUB6 0.006 0.0049 0.0104
Loa Loa (eye worm) tubulin beta-2A chain 0.1257 0.1631 0.1772
Loa Loa (eye worm) hypothetical protein 0.0068 0.006 0.0065
Loa Loa (eye worm) histone deacetylase 7A 0.022 0.0259 0.0282
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0037 0.0018 0.0018
Schistosoma mansoni neprilysin 0.0024 0.0001 0.0001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0004 0.0004
Toxoplasma gondii histone deacetylase HDAC5 0.0105 0.0108 0.0248
Schistosoma mansoni tyrosine kinase 0.0101 0.0103 0.021
Schistosoma mansoni maguk P55 subfamily member 35 0.0037 0.0018 0.0036
Loa Loa (eye worm) melatonin receptor type 1A 0.1228 0.1592 0.173
Toxoplasma gondii subtilisin SUB9 0.006 0.0049 0.0104
Onchocerca volvulus 0.1228 0.1592 0.6804
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0168 0.0183
Onchocerca volvulus 0.0052 0.0038 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0044 0.0048
Onchocerca volvulus 0.0081 0.0076 0.0327
Onchocerca volvulus 0.005 0.0035 0.0149
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0044 0.009
Trypanosoma brucei metacaspase 5, putative 0.0118 0.0124 0.0601
Loa Loa (eye worm) hypothetical protein 0.0197 0.0229 0.0249
Brugia malayi Angiotensin-converting enzyme family protein 0.6985 0.9202 1
Loa Loa (eye worm) neuropeptide F receptor 0.1228 0.1592 0.173
Echinococcus granulosus alpha 1A adrenergic receptor 0.1228 0.1592 0.1592
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Schistosoma mansoni neuropeptide f receptor 76f 0.1228 0.1592 0.3243
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0316 0.1897
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0012 0.0012
Loa Loa (eye worm) matrixin family protein 0.011 0.0115 0.0125
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0591
Echinococcus granulosus histone deacetylase 6 0.022 0.0259 0.0259
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0024 0.0101
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0054 0.0059
Brugia malayi hypothetical protein 0.1228 0.1592 0.173
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1228 0.1592 0.6804
Brugia malayi Guanylate kinase family protein 0.0052 0.0038 0.0041
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0282
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0004 0.0005
Loa Loa (eye worm) apoptosis regulator protein 0.0139 0.0153 0.0166
Echinococcus multilocularis dnaJ subfamily B 0.1785 0.2329 0.2329
Brugia malayi ephrin receptor 1 precursor 0.0105 0.0108 0.0118
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.006 0.0049 0.1004
Echinococcus granulosus insulin degrading enzyme 0.0071 0.0063 0.0063
Echinococcus multilocularis nmda type glutamate receptor 0.0116 0.0123 0.0123
Schistosoma mansoni zinc finger protein 0.0027 0.0004 0.0009
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1228 0.1592 0.173
Brugia malayi Subtilase family protein 0.006 0.0049 0.0053
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.0066
Onchocerca volvulus 0.0056 0.0043 0.0182
Echinococcus granulosus histone deacetylase 7 0.022 0.0259 0.0259
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0004 0.0009
Onchocerca volvulus 0.1228 0.1592 0.6804
Echinococcus granulosus tyrosine protein kinase HCK 0.0071 0.0063 0.0063
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0024 0.0405
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.003 0.0008 0.0009
Trypanosoma cruzi histone deacetylase, putative 0.022 0.0259 0.1549
Echinococcus multilocularis Tubulin beta 2C chain 0.1257 0.1631 0.1631
Schistosoma mansoni nardilysin (M16 family) 0.0071 0.0063 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Echinococcus granulosus fmrfamide receptor 0.1228 0.1592 0.1592
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Brugia malayi hypothetical protein 0.0026 0.0003 0.0003
Echinococcus granulosus tgf beta family 0.0033 0.0012 0.0012
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0197 0.0229 0.0229
Schistosoma mansoni biogenic amine (5HT) receptor 0.1346 0.1749 0.3563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1228 0.1592 0.3243
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Echinococcus multilocularis deoxyribonuclease ii 0.0073 0.0065 0.0065
Giardia lamblia Beta tubulin 0.1257 0.1631 1
Plasmodium vivax aspartyl proteinase, putative 0.0097 0.0097 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0124 0.0717
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0009 0.0019
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0064 0.0054 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0024 0.0085
Loa Loa (eye worm) hypothetical protein 0.0115 0.0121 0.0131
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1228 0.1592 0.1592
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0004 0.0009
Echinococcus granulosus high voltage activated calcium channel beta 0.003 0.0008 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.1228 0.1592 0.173
Onchocerca volvulus 0.0033 0.0012 0.0053
Schistosoma mansoni apoptosis regulator bax 0.0139 0.0153 0.0312
Schistosoma mansoni cpg binding protein 0.0031 0.001 0.0021
Leishmania major C-8 sterol isomerase-like protein 0.0374 0.0464 0.2808
Brugia malayi Peripheral plasma membrane protein CASK 0.0052 0.0038 0.0041
Onchocerca volvulus Matrix metalloproteinase homolog 0.011 0.0115 0.0491
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.006 0.0049 0.0049
Brugia malayi nuclear receptor NHR-88 0.0057 0.0044 0.0048
Echinococcus granulosus histone deacetylase 1 0.0244 0.0292 0.0292
Trypanosoma cruzi tyrosine phosphatase, putative 0.0056 0.0043 0.0215
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0197 0.0229 0.0229
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0061 0.0049 0.1011
Plasmodium falciparum metacaspase-like protein 0.0118 0.0124 0.0717
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0097 0.0097 0.0198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0128 0.0138 0.0138
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0009 0.0019
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0118 0.0124 0.0288
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0037 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor 0.1538 0.2002 0.2002
Loa Loa (eye worm) cuticular endochitinase 0.0075 0.0068 0.0074
Plasmodium falciparum histone deacetylase 1 0.0244 0.0292 0.1747
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0034 0.007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0034 0.0034
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Onchocerca volvulus 0.1228 0.1592 0.6804
Onchocerca volvulus 0.1228 0.1592 0.6804
Loa Loa (eye worm) TK/EGFR protein kinase 0.016 0.018 0.0196
Echinococcus multilocularis zinc finger protein Ran binding 0.0064 0.0054 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0316 0.1897
Onchocerca volvulus Neuropeptide F receptor homolog 0.1228 0.1592 0.6804
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0044 0.009
Echinococcus granulosus furin 0.1312 0.1703 0.1703
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0076 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis fmrfamide receptor 0.1228 0.1592 0.1592
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0047 0.01
Giardia lamblia Furin precursor putative serine protease 0.0273 0.033 0.1983
Trypanosoma cruzi histone deacetylase, putative 0.022 0.0259 0.1549
Loa Loa (eye worm) BEN-1 protein 0.1257 0.1631 0.1772
Echinococcus granulosus tyrosine protein kinase csk 0.004 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0049 0.0251
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0064 0.0054 0.0282
Loa Loa (eye worm) hypothetical protein 0.0118 0.0125 0.0136
Brugia malayi SRC-1 0.0101 0.0103 0.0112
Onchocerca volvulus Cell death protein 3 homolog 0.0167 0.019 0.0813
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0044 0.0044
Brugia malayi Deoxyribonuclease II family protein 0.0073 0.0065 0.0071
Trichomonas vaginalis hypothetical protein 0.0273 0.033 0.1983
Brugia malayi endochitinase 0.0075 0.0068 0.0074
Schistosoma mansoni histamine h1 receptor 0.1228 0.1592 0.3243
Plasmodium falciparum plasmepsin II 0.0097 0.0097 0.055
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.005 0.0035 0.0071
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Trypanosoma brucei histone deacetylase 2 0.0105 0.0108 0.0515
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.009 0.2011
Brugia malayi abnormal cell lineage protein 2 0.003 0.0008 0.0009
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.009 0.2011
Plasmodium vivax hypothetical protein, conserved 0.018 0.0208 0.1229
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0064 0.0054 0.0117
Schistosoma mansoni neuropeptide receptor 0.1228 0.1592 0.3243
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0015 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0024 0.0085
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0034 0.0034
Schistosoma mansoni alpha-1 adrenergic receptor 0.1228 0.1592 0.3243
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.1228 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0101 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.1228 0.1592 0.1592
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0004 0.0005
Echinococcus multilocularis histone deacetylase 1 0.0244 0.0292 0.0292
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1228 0.1592 0.1592
Plasmodium vivax subtilisin-like protease 2, putative 0.006 0.0049 0.0251
Loa Loa (eye worm) hypothetical protein 0.1695 0.221 0.2401
Echinococcus multilocularis sex peptide receptor 0.1228 0.1592 0.1592
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0012 0.0012
Schistosoma mansoni nuclear receptor 0.0027 0.0004 0.0009
Echinococcus granulosus g protein coupled receptor 0.1228 0.1592 0.1592
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0062 0.0051 0.0216
Schistosoma mansoni serine-type protease inhibitor 0.1807 0.2358 0.4804
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus granulosus caspase 8 0.0118 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0097 0.0097 0.0106
Echinococcus multilocularis integrin alpha ps 0.0068 0.0058 0.0058
Schistosoma mansoni P2X receptor subunit 0.0134 0.0146 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0809 0.1039 0.1039
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0044 0.0044
Toxoplasma gondii histone deacetylase HDAC4 0.0105 0.0108 0.0248
Brugia malayi EGF-like domain containing protein 0.003 0.0009 0.0009
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0139 0.0153 0.0312
Leishmania major beta tubulin 0.1257 0.1631 1
Echinococcus multilocularis Furin 1 0.0333 0.041 0.041
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0101 0.0103 0.0103
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1228 0.1592 0.173
Brugia malayi nuclear receptor NHR-67 0.0027 0.0004 0.0005
Echinococcus granulosus SWI:SNF matrix associated 0.018 0.0208 0.0208
Echinococcus granulosus Furin 1 0.0333 0.041 0.041
Loa Loa (eye worm) TYRA-2 protein 0.1228 0.1592 0.173
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.003 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0118 0.0124 0.0253
Onchocerca volvulus 0.018 0.0208 0.0887
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Brugia malayi neuroendocrine convertase 1 precursor 0.0836 0.1074 0.1167
Loa Loa (eye worm) hypothetical protein 0.0076 0.007 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0024 0.0101
Schistosoma mansoni family M16 unassigned peptidase (M16 family) 0.0028 0.0006 0.0012
Brugia malayi POT family protein 0.0039 0.0021 0.0023
Brugia malayi endoprotease bli-4 precursor 0.1312 0.1703 0.1851
Brugia malayi hypothetical protein 0.1646 0.2145 0.2331
Echinococcus granulosus beta tubulin 0.1257 0.1631 0.1631
Brugia malayi Matrixin family protein 0.005 0.0035 0.0038
Schistosoma mansoni hypothetical protein 0.0139 0.0153 0.0312
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.003 0.0061
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0044 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0049 0.0251
Echinococcus granulosus integrin alpha 3 0.0116 0.0122 0.0122
Toxoplasma gondii sporozoite developmental protein 0.0071 0.0063 0.0138
Toxoplasma gondii histone deacetylase HDAC3 0.0244 0.0292 0.0696
Brugia malayi Matrixin family protein 0.005 0.0035 0.0038
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis high voltage activated calcium channel beta 0.003 0.0008 0.0008
Schistosoma mansoni chromobox protein 0.0202 0.0236 0.0482
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0009 0.001
Brugia malayi proprotein convertase 2 0.0836 0.1074 0.1167
Echinococcus multilocularis tyrosine protein kinase Blk 0.0086 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase Lyn 0.0102 0.0104 0.0104
Echinococcus granulosus NCK adaptor protein 0.0031 0.0009 0.0009
Loa Loa (eye worm) tubulin beta chain 0.1257 0.1631 0.1772
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1228 0.1592 0.1592
Trichomonas vaginalis histone deacetylase, putative 0.0244 0.0292 0.1747
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0059
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0076 0.007 0.007
Echinococcus multilocularis bone morphogenetic protein 2 0.0033 0.0012 0.0012
Schistosoma mansoni guanylate kinase 0.003 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0024 0.0024
Echinococcus granulosus integrin beta 2 0.0948 0.1223 0.1223
Loa Loa (eye worm) G-protein coupled receptor 0.1228 0.1592 0.173
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.006 0.0049 0.0049
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0276 0.0333 0.0333
Brugia malayi Tyrosine-protein kinase abl-1 0.0135 0.0148 0.016
Schistosoma mansoni furin-1 (S08 family) 0.0563 0.0713 0.1453
Schistosoma mansoni P2X receptor subunit 0.0134 0.0146 0.0297
Onchocerca volvulus 0.003 0.0009 0.0036
Brugia malayi Tyrosine-protein kinase abl-1 0.0121 0.0129 0.014
Schistosoma mansoni maguk P55 subfamily member 26 0.0037 0.0018 0.0036
Echinococcus multilocularis histone deacetylase 7 0.022 0.0259 0.0259
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0004 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0034 0.0069
Echinococcus multilocularis g protein coupled receptor 0.1228 0.1592 0.1592
Loa Loa (eye worm) glutamate receptor 1 0.0033 0.0012 0.0013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0118 0.0124 0.0717
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0244 0.0292 0.0317
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0044 0.0048
Schistosoma mansoni opsin-like receptor 0.1228 0.1592 0.3243
Loa Loa (eye worm) hypothetical protein 0.0027 0.0004 0.0005
Schistosoma mansoni site-1 peptidase (S08 family) 0.006 0.0049 0.0099
Echinococcus multilocularis GPCR, family 2 0.0033 0.0012 0.0012
Brugia malayi Glutamate receptor 1 precursor 0.0033 0.0012 0.0013
Schistosoma mansoni hypothetical protein 0.1228 0.1592 0.3243
Trichomonas vaginalis deoxyribonuclease II, putative 0.0073 0.0065 0.0353
Echinococcus granulosus GPCR family 2 0.0033 0.0012 0.0012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0034 0.0034
Trypanosoma brucei metacaspase 0.0118 0.0124 0.0601
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.0122 0.0591
Echinococcus multilocularis MAGUK p55 subfamily 0.0037 0.0018 0.0018
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1228 0.1592 0.1592
Echinococcus granulosus segment polarity protein dishevelled 0.0103 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Loa Loa (eye worm) hypothetical protein 0.0103 0.0106 0.0115
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.009 0.009
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0056 0.0043 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0197 0.1162
Schistosoma mansoni hypothetical protein 0.0038 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0101 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0048
Toxoplasma gondii hypothetical protein 0.003 0.0009 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.1228 0.1592 0.1592
Schistosoma mansoni P2X receptor subunit 0.0134 0.0146 0.0297
Loa Loa (eye worm) hypothetical protein 0.1228 0.1592 0.173

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 24.4 nM Inhibition of human caspase 3 by fluorometric assay ChEMBL. 21441025
IC50 (binding) = 68.3 nM Inhibition of caspase 7 by fluorometric assay ChEMBL. 21441025
IC50 (binding) = 1012 nM Inhibition of caspase 6 by fluorometric assay ChEMBL. 21441025
IC50 (binding) = 5733 nM Inhibition of caspase 1 by fluorometric assay ChEMBL. 21441025
IC50 (binding) > 50000 nM Inhibition of caspase 8 by fluorometric assay ChEMBL. 21441025

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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