Detailed information for compound 1532873

Basic information

Technical information
  • TDR Targets ID: 1532873
  • Name: Reserpic acid hydrochloride
  • MW: 436.929 | Formula: C22H29ClN2O5
  • H donors: 3 H acceptors: 3 LogP: 0.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1[C@H](O)C[C@H]2[C@@H]([C@@H]1C(=O)O)C[C@H]1N(C2)CCc2c1[nH]c1c2ccc(c1)OC.Cl
  • InChi: 1S/C22H28N2O5.ClH/c1-28-12-3-4-13-14-5-6-24-10-11-7-18(25)21(29-2)19(22(26)27)15(11)9-17(24)20(14)23-16(13)8-12;/h3-4,8,11,15,17-19,21,23,25H,5-7,9-10H2,1-2H3,(H,26,27);1H/t11-,15+,17-,18-,19+,21+;/m1./s1
  • InChiKey: QLKKMNXYROCXRE-BCRILHLVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0021 0.0004 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0064 0.0064
Echinococcus multilocularis dna polymerase eta 0.0021 0.0004 0.0004
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0016 0.0624
Schistosoma mansoni hypothetical protein 0.0515 0.0579 0.0953
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0203 0.0334
Entamoeba histolytica acyl-CoA synthetase, putative 0.0314 0.0345 0.3504
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0092 0.0087 0.2495
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Entamoeba histolytica hypothetical protein 0.0238 0.0257 0.2601
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0041 0.1671
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0215 0.023 0.1913
Loa Loa (eye worm) hypothetical protein 0.0314 0.0345 0.2871
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0003 0.007
Echinococcus multilocularis Niemann Pick C1 protein 0.1227 0.1408 0.1408
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0022 0.0856
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0087 0.0718
Schistosoma mansoni heat shock protein 0.0031 0.0016 0.0026
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0019 0.0152
Loa Loa (eye worm) hypothetical protein 0.0044 0.0031 0.0247
Schistosoma mansoni inositol monophosphatase 0.0042 0.0028 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Plasmodium falciparum glutathione reductase 0.0053 0.0041 0.1608
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0314 0.0345 0.059
Schistosoma mansoni nuclear receptor 0.0034 0.0019 0.0031
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0023 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0215 0.023 0.1913
Loa Loa (eye worm) hypothetical protein 0.0226 0.0243 0.2019
Onchocerca volvulus 0.074 0.0841 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0186
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0022 0.0603
Mycobacterium tuberculosis Probable esterase LipL 0.0226 0.0243 0.0424
Schistosoma mansoni DNA ligase IV 0.0044 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0053 0.0041 0.033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.005 0.1932
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0064 0.0523
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.0064 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0011 0.0086
Loa Loa (eye worm) inositol-1 0.0042 0.0028 0.0219
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0064 0.0104
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0281 0.234
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0085 0.0139
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0092 0.0087 0.015
Brugia malayi Muscleblind-like protein 0.0153 0.0158 0.131
Onchocerca volvulus 0.0052 0.004 0.0255
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0019 0.0031
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0092 0.0087 0.3545
Leishmania major acetyl-CoA synthetase, putative 0.0092 0.0087 0.2495
Schistosoma mansoni tar DNA-binding protein 0.0215 0.023 0.0379
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0046 0.1878
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0007 0.0243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0213 0.0228 0.1897
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0235 0.0253 0.0441
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0226 0.0243 0.0424
Toxoplasma gondii patched family protein 0.0052 0.004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0167 0.0173 0.1436
Brugia malayi glutaminase DH11.1 0.0269 0.0292 0.2435
Onchocerca volvulus Protein patched homolog 0.0052 0.004 0.0255
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0092 0.0087 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0226 0.0243 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0314 0.0345 0.0603
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Leishmania major hypothetical protein, conserved 0.0226 0.0243 0.7038
Mycobacterium tuberculosis Conserved protein 0.0226 0.0243 0.0424
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0125 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Echinococcus granulosus sterol regulatory element binding protein 0.0369 0.0409 0.0672
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0011 0.0427
Mycobacterium tuberculosis Probable reductase 0.0121 0.0121 0.021
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Giardia lamblia Replication factor C, subunit 1 0.0044 0.0031 0.4185
Brugia malayi nuclear receptor NHR-67 0.0034 0.0019 0.0152
Plasmodium vivax replication factor C subunit 1, putative 0.0044 0.0031 0.1204
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0051 0.0412
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.0121 0.021
Toxoplasma gondii patched family protein 0.0052 0.004 0.0069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0019 0.0019
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0022 0.0247
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0022 0.0167
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0002 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.0064 0.0104
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0002 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0019 0.0152
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0019 0.0019
Plasmodium falciparum thioredoxin reductase 0.0053 0.0041 0.1608
Onchocerca volvulus 0.0226 0.0243 0.2723
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Brugia malayi isocitrate dehydrogenase 0.0019 0.0002 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0314 0.0345 1
Onchocerca volvulus 0.0057 0.0046 0.0327
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.0121 0.021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0022 0.0195
Brugia malayi AMP-binding enzyme family protein 0.0314 0.0345 0.2875
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0046 0.0541
Brugia malayi Patched related family protein 10 0.0052 0.004 0.0327
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0053 0.0041 0.007
Loa Loa (eye worm) hypothetical protein 0.036 0.0398 0.3318
Mycobacterium tuberculosis Probable lipase LipE 0.0226 0.0243 0.0424
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0136 0.0238
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.0064 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0001 0.0002
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0053 0.0041 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0226 0.0243 1
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0016 0.0624
Loa Loa (eye worm) hypothetical protein 0.0044 0.0031 0.0247
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0064 0.0104
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0121 0.021
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0092 0.0087 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0031 0.1251
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0053 0.0041 0.1661
Echinococcus granulosus histone acetyltransferase KAT2B 0.0291 0.0318 0.0523
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0136 0.0224
Giardia lamblia Grp94/Hsp90 0.0025 0.0009 0.1057
Loa Loa (eye worm) hypothetical protein 0.0044 0.0031 0.0247
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Echinococcus multilocularis zinc finger protein 0.0029 0.0014 0.0014
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0003 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0203 0.0334
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0011 0.0019
Brugia malayi nuclear receptor NHR-88 0.0034 0.0019 0.0152
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 0.0319
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0092 0.0087 0.0712
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0064 0.0104
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0301 0.033 0.033
Plasmodium falciparum heat shock protein 90 0.0031 0.0016 0.06
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0003 0.0049
Brugia malayi protein C24B5.3 0.0052 0.004 0.0327
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0046 0.628
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0019 0.0031
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0024 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0024 0.0039
Mycobacterium ulcerans esterase/lipase LipP 0.0226 0.0243 0.0424
Loa Loa (eye worm) hypothetical protein 0.0235 0.0253 0.2098
Schistosoma mansoni zinc finger protein 0.0029 0.0014 0.0023
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0009 0.0091
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0175 0.0183 0.1515
Echinococcus granulosus Niemann Pick C1 protein 0.0859 0.0979 0.1611
Brugia malayi PHD-finger family protein 0.0035 0.002 0.0158
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0073 0.2877
Mycobacterium leprae Probable lipase LipE 0.0226 0.0243 0.0411
Schistosoma mansoni glutaminase 0.0269 0.0292 0.0481
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Onchocerca volvulus 0.0094 0.0089 0.0854
Echinococcus granulosus GPCR family 2 0.0167 0.0173 0.0285
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0002 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0004 0.0005
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0003 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.0087 0.015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.0087 0.015
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0177 0.1923
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.0064 0.0517
Loa Loa (eye worm) patched family protein 0.0052 0.004 0.0321
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0222 0.0238 0.0415
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0046 0.0046
Trichomonas vaginalis esterase, putative 0.0226 0.0243 0.2881
Brugia malayi protein C24B5.3 0.0052 0.004 0.0327
Echinococcus granulosus microtubule associated protein 2 0.5239 0.6078 1
Loa Loa (eye worm) RNA binding protein 0.0215 0.023 0.1913
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0001 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Brugia malayi jmjC domain containing protein 0.0199 0.0211 0.1754
Schistosoma mansoni jumonji/arid domain-containing protein 0.0204 0.0217 0.0357
Toxoplasma gondii patched family protein 0.0052 0.004 0.0069
Brugia malayi Patched protein homolog 1 0.0052 0.004 0.0327
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0247
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.002 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0028 0.1112
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Brugia malayi hypothetical protein 0.0044 0.0031 0.0253
Loa Loa (eye worm) hypothetical protein 0.0226 0.0243 0.2019
Schistosoma mansoni cpg binding protein 0.0062 0.0052 0.0086
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0016 0.0624
Plasmodium vivax acetyl-CoA synthetase, putative 0.0092 0.0087 0.3412
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0019 0.0019
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0016 0.2086
Leishmania major acetyl-CoA synthetase, putative 0.0092 0.0087 0.2495
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Schistosoma mansoni heat shock protein 0.0031 0.0016 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Treponema pallidum DNA ligase (lig) 0.0044 0.0031 0.1665
Brugia malayi Pax transcription activation domain interacting protein 0.0044 0.0031 0.0253
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0041 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis glutaminase, putative 0.0269 0.0292 0.3466
Toxoplasma gondii ATPase, AAA family protein 0.0044 0.0031 0.0053
Toxoplasma gondii pantoate-beta-alanine ligase 0.492 0.5708 1
Toxoplasma gondii ABC1 family protein 0.0226 0.0243 0.0424
Schistosoma mansoni survival motor neuron protein 0.0213 0.0228 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0022 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0226 0.0243 0.2019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.0064 0.0104
Schistosoma mansoni inositol monophosphatase 0.0042 0.0028 0.0046
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Brugia malayi Bromodomain containing protein 0.0044 0.0031 0.0252
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0022 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.0064 0.0517
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0226 0.0243 0.2024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0089 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0314 0.0345 0.059
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0072 0.0124
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Trichomonas vaginalis replication factor C large subunit, putative 0.0044 0.0031 0.036
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0003 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0046 0.0448
Echinococcus multilocularis tar DNA binding protein 0.0215 0.023 0.023
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0092 0.0087 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Brugia malayi hypothetical protein 0.0038 0.0024 0.0192
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0041 0.1608
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Onchocerca volvulus 0.0052 0.004 0.0255
Onchocerca volvulus 0.0052 0.004 0.0255
Brugia malayi Patched related family protein 12 0.0052 0.004 0.0327
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Onchocerca volvulus 0.0092 0.0087 0.0823
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0009 0.0014
Schistosoma mansoni nuclear receptor 0.0034 0.0019 0.0031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0002 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.036 0.0398 0.3322
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0019 0.071
Echinococcus granulosus dna polymerase kappa 0.0021 0.0004 0.0007
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0053 0.0041 0.1661
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0004 0.002
Mycobacterium ulcerans glutaminase 0.0269 0.0292 0.051
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0003 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0226 0.0243 0.2019
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0019 0.0152
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0004 0.002
Entamoeba histolytica hypothetical protein 0.0238 0.0257 0.2601
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0136 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0167 0.0173 0.1441
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.002
Entamoeba histolytica hypothetical protein 0.0034 0.0019 0.0166
Brugia malayi CHE-14 protein 0.0369 0.0409 0.3407
Brugia malayi hypothetical protein 0.0038 0.0024 0.0192
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0526 0.0592 0.4942
Schistosoma mansoni jumonji domain containing protein 0.0199 0.0211 0.0347
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0059 0.0097
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0016 0.06
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0046 0.038
Loa Loa (eye worm) glutaminase 0.0269 0.0292 0.243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0064 0.0523
Entamoeba histolytica hypothetical protein 0.0044 0.0031 0.0293
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0019 0.0146
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0044 0.0031 0.0253
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0022 0.0022
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0092 0.0087 0.015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0002 0.0031
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0247
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0175 0.0183 0.0183
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0009 0.0014
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0016 0.0137
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0011 0.0427
Entamoeba histolytica hypothetical protein 0.0238 0.0257 0.2601
Echinococcus multilocularis thyroid hormone receptor alpha 0.0072 0.0064 0.0064
Plasmodium falciparum acyl-CoA synthetase 0.0235 0.0253 1
Brugia malayi topoisomerase 0.0044 0.0031 0.0253
Schistosoma mansoni hypothetical protein 0.0167 0.0173 0.0285
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0044 0.0031 0.036
Brugia malayi hypothetical protein 0.1046 0.1197 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0085 0.0995
Brugia malayi Thioredoxin reductase 0.0053 0.0041 0.0338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0526 0.0592 0.4939
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0092 0.0087 0.015
Brugia malayi jmjC domain containing protein 0.0053 0.0041 0.0336
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.005 0.1932
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0008 0.0052
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Echinococcus multilocularis heat shock protein 90 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Onchocerca volvulus 0.0052 0.004 0.0255
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0044 0.0031 0.1251
Mycobacterium ulcerans hypothetical protein 0.0226 0.0243 0.0424
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0019 0.0166
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0047 0.0077
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0002 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0019 0.0031
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Brugia malayi hypothetical protein 0.0052 0.004 0.0327
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0301 0.033 0.0543
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0002 0.0003
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0003 0.007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0314 0.0345 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0409 0.485
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0019 0.0031
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0024 0.0039
Schistosoma mansoni patched 1 0.0369 0.0409 0.0672
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0092 0.0087 0.015
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.0064 0.0517
Onchocerca volvulus 0.0072 0.0064 0.054
Brugia malayi nuclear receptor NHR-88 0.0072 0.0064 0.0523
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0247
Brugia malayi Calcitonin receptor-like protein seb-1 0.0526 0.0592 0.4942
Schistosoma mansoni hypothetical protein 0.0238 0.0257 0.0422
Brugia malayi RNA binding protein 0.0215 0.023 0.1918
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0003 0.007
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0003 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.0064 0.0517
Schistosoma mansoni phd/f-box containing protein 0.0053 0.0041 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0002 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0044 0.0031 0.1665
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0019 0.0152
Onchocerca volvulus 0.0092 0.0087 0.0823
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0031 0.036
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0226 0.0243 0.2881
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0041 0.0071
Echinococcus granulosus muscleblind protein 0.0153 0.0158 0.0259
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0226 0.0243 0.0424
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.0064 0.0064
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.492 0.5708 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0028 0.1479
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Echinococcus granulosus FTZ F1 alpha 0.0072 0.0064 0.0104
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.007
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0009 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0031 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0041 0.033
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.0087 0.015
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.0064 0.054
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0022 0.0247
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.006 0.005 0.0072
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0092 0.0087 0.0143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0226 0.0243 0.0424
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0019 0.0152
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0153 0.0157 0.1302
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0004 0.0129
Loa Loa (eye worm) endoplasmin 0.0031 0.0016 0.012
Plasmodium vivax JmjC domain containing protein 0.0053 0.0041 0.1599
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0044 0.0031 0.1251
Loa Loa (eye worm) hypothetical protein 0.0235 0.0253 0.2098
Brugia malayi Bromodomain containing protein 0.0083 0.0076 0.0629
Echinococcus granulosus replication factor c subunit 1 0.0044 0.0031 0.0051
Schistosoma mansoni hypothetical protein 0.0167 0.0173 0.0285
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0003 0.007
Loa Loa (eye worm) hypothetical protein 0.0451 0.0505 0.4211
Loa Loa (eye worm) hypothetical protein 0.0044 0.0031 0.0247
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Onchocerca volvulus 0.0092 0.0087 0.0823
Echinococcus granulosus JmjC domain containing protein 4 0.0053 0.0041 0.0068
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0003 0.0049
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0175 0.0183 0.0319
Loa Loa (eye worm) hypothetical protein 0.0092 0.0087 0.0712
Schistosoma mansoni tar DNA-binding protein 0.0215 0.023 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Echinococcus multilocularis phd:f box containing protein 0.0053 0.0041 0.0041
Leishmania major DNA polymerase kappa, putative 0.0021 0.0004 0.0091
Onchocerca volvulus 0.0052 0.004 0.0255
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0009 0.0013
Echinococcus multilocularis replication factor c subunit 1 0.0044 0.0031 0.0031
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0175 0.0183 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0085 0.0146
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0186
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0092 0.0087 0.3545
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0053 0.0041 0.1661
Treponema pallidum heat shock protein 90 0.0025 0.0009 0.0421
Brugia malayi nuclear hormone receptor 0.0072 0.0064 0.0523
Loa Loa (eye worm) hypothetical protein 0.0153 0.0158 0.1304
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0059 0.0097
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0019 0.0031
Brugia malayi Endoplasmin precursor 0.0031 0.0016 0.0126
Loa Loa (eye worm) hypothetical protein 0.1046 0.1197 1
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0046 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0281 0.333
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Onchocerca volvulus 0.0052 0.004 0.0255
Brugia malayi glutathione reductase 0.0053 0.0041 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0051 0.0595
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0004 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0087 0.0718
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0006 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.0064 0.0104
Toxoplasma gondii exonuclease III APE 0.0057 0.0046 0.008
Leishmania major DNA polymerase eta, putative 0.0021 0.0004 0.0091
Schistosoma mansoni DNA polymerase eta 0.0021 0.0004 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0369 0.0409 0.3403
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Toxoplasma gondii propionate-CoA ligase 0.0092 0.0087 0.015
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Echinococcus multilocularis protein patched 0.0369 0.0409 0.0409
Brugia malayi beta-lactamase family protein 0.0226 0.0243 0.2024
Echinococcus multilocularis nibrin 0.0044 0.0031 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0004 0.0005
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0016 0.018
Entamoeba histolytica hypothetical protein 0.0027 0.0011 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0314 0.0345 0.2875
Trichomonas vaginalis antibiotic synthetase, putative 0.0092 0.0087 0.1021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0046 0.1878
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.0064 0.0104
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0028 0.1112
Echinococcus multilocularis sterol regulatory element binding protein 0.0369 0.0409 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0153 0.0158 0.1304
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0044 0.0031 0.036
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0092 0.0087 0.3545
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.0064 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0059 0.0102
Onchocerca volvulus 0.0226 0.0243 0.2723
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0041 0.033
Brugia malayi Steroid receptor seven-up type 2 0.0072 0.0064 0.0523
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0089 0.0147
Brugia malayi hypothetical protein 0.0034 0.0019 0.0152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 0.723
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0002 0.0031
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0175 0.0183 0.723
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0092 0.0087 0.0137
Brugia malayi CXXC zinc finger family protein 0.0057 0.0046 0.0377
Loa Loa (eye worm) patched family protein 0.0052 0.004 0.0321
Brugia malayi conserved hypotetical protein 0.0034 0.0019 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0314 0.0345 0.2871
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.044 0.044
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0004 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0013 0.0501
Loa Loa (eye worm) hypothetical protein 0.0859 0.0979 0.8178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0203 0.0334
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0046 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.0064 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0226 0.0243 0.9623
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0872 0.0995 0.1636
Trichomonas vaginalis D-aminoacylase, putative 0.0226 0.0243 0.2881
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0003 0.0049
Trypanosoma brucei trypanothione reductase 0.0053 0.0041 0.1671
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0019 0.0738
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0235 0.0253 0.0441
Echinococcus granulosus nibrin 0.0044 0.0031 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0087 0.0718
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0109 0.0179
Brugia malayi Pre-SET motif family protein 0.0094 0.0089 0.0739
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0019 0.0031
Echinococcus granulosus peptidase Clp S14 family 0.0114 0.0113 0.0186
Echinococcus multilocularis cpg binding protein 0.0062 0.0052 0.0052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0046 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0238 0.0257 0.0422
Entamoeba histolytica acyl-coA synthetase, putative 0.0314 0.0345 0.3504
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0235 0.0253 0.2098
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Schistosoma mansoni endoplasmin 0.0031 0.0016 0.0026
Schistosoma mansoni endoplasmin 0.0031 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0111 0.0109 0.0894
Brugia malayi photoreceptor-specific nuclear receptor 0.0072 0.0064 0.0523
Echinococcus granulosus transcription factor btf3 0.0034 0.0019 0.0031
Toxoplasma gondii hypothetical protein 0.006 0.005 0.0085
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.017 0.141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0016 0.0624
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0013 0.0021
Mycobacterium tuberculosis Probable lipase LipD 0.0226 0.0243 0.0424
Brugia malayi hypothetical protein 0.0044 0.0031 0.0253
Entamoeba histolytica acyl-CoA synthetase, putative 0.0314 0.0345 0.3504
Schistosoma mansoni ap endonuclease 0.0057 0.0046 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Brugia malayi ecdysone receptor 0.0034 0.0019 0.0152
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0024 0.0008 0.0288
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0004
Brugia malayi beta-lactamase 0.0226 0.0243 0.2024
Echinococcus multilocularis lysine specific demethylase 6a 0.0053 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0019 0.071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0064 0.0523
Echinococcus multilocularis protein dispatched 1 0.0421 0.0469 0.0469
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0281 0.333
Schistosoma mansoni tar DNA-binding protein 0.0215 0.023 0.0379
Loa Loa (eye worm) hypothetical protein 0.0068 0.0059 0.048
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0009 0.0014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0029 0.0013 0.0353
Onchocerca volvulus 0.0044 0.0031 0.0147
Brugia malayi hypothetical protein 0.0029 0.0013 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0167 0.0173 0.0285
Echinococcus granulosus tumor protein p63 0.1044 0.1195 0.1966
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Schistosoma mansoni hypothetical protein 0.0515 0.0579 0.0953
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0175 0.0183 0.0319
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0114 0.0113 0.0183
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0041 0.0332
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0019 0.0031
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0053 0.0041 0.0068
Loa Loa (eye worm) glutaminase 2 0.0269 0.0292 0.243
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0003 0.0051
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0028 0.0046
Brugia malayi hypothetical protein 0.0052 0.004 0.0327
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.0064 0.054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0034 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0003 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0004 0.0129
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0199 0.0211 0.0211
Echinococcus multilocularis muscleblind protein 0.0153 0.0158 0.0158
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.017 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0203 0.0203
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0028 0.032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.0064 0.0523
Echinococcus multilocularis transcription factor btf3 0.0034 0.0019 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.0064 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0247
Loa Loa (eye worm) hypothetical protein 0.0526 0.0592 0.4939
Schistosoma mansoni alpha-glucosidase 0.0141 0.0143 0.0235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0203 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.0123
Echinococcus granulosus jumonji domain containing 1A 0.0053 0.0041 0.0068
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0046 0.2499
Trichomonas vaginalis D-aminoacylase, putative 0.0226 0.0243 0.2881
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.0064 0.0523
Loa Loa (eye worm) patched family protein 0.0052 0.004 0.0321
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0059 0.0059
Echinococcus multilocularis beta LACTamase domain containing family member 0.0226 0.0243 0.0243
Echinococcus granulosus lysine specific demethylase 6a 0.0053 0.0041 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0002 0.0002
Brugia malayi Myosin head containing protein 0.0052 0.004 0.0327
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.0064 0.0064
Giardia lamblia GTOR 0.002 0.0003 0.0234
Loa Loa (eye worm) hypothetical protein 0.0235 0.0253 0.2098
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Trichomonas vaginalis antibiotic synthetase, putative 0.0092 0.0087 0.1021
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Plasmodium vivax patched family protein, putative 0.0052 0.004 0.1557
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0004 0.0007
Echinococcus granulosus phd:f box containing protein 0.0053 0.0041 0.0068
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0022 0.0195
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Chlamydia trachomatis DNA ligase 0.0044 0.0031 0.1204
Echinococcus multilocularis expressed conserved protein 0.0807 0.0919 0.0919
Mycobacterium ulcerans acyl-CoA synthetase 0.0314 0.0345 0.0603
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0002 0.003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Trypanosoma brucei glucosidase, putative 0.0036 0.0022 0.0856
Brugia malayi hypothetical protein 0.0034 0.0019 0.0152
Echinococcus granulosus zinc finger protein 0.0029 0.0014 0.0023
Mycobacterium ulcerans beta-lactamase 0.0226 0.0243 0.0424
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0226 0.0243 0.04
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0314 0.0345 0.0603
Brugia malayi nuclear hormone receptor 0.0034 0.0019 0.0152
Loa Loa (eye worm) jmjC domain-containing protein 0.0204 0.0217 0.1799
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0019 0.0146
Loa Loa (eye worm) hypothetical protein 0.0369 0.0409 0.3403
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0167 0.0173 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0001 0.0005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0355 0.0393 0.0647
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0167 0.0173 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0019 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.5239 0.6078 0.6078
Mycobacterium ulcerans acetyl-CoA synthetase 0.0092 0.0087 0.015
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0319
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0009 0.0223
Brugia malayi ecdysteroid receptor 0.0072 0.0064 0.0523
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0051 0.0084
Echinococcus granulosus geminin 0.0515 0.0579 0.0953
Schistosoma mansoni cpg binding protein 0.0057 0.0046 0.0076
Trypanosoma cruzi FHA domain containing protein, putative 0.0044 0.0031 0.1251
Trichomonas vaginalis set domain proteins, putative 0.074 0.0841 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0003 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0226 0.0243 0.2881
Schistosoma mansoni hypothetical protein 0.036 0.0398 0.0655
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0022 0.0856
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0028 0.032
Brugia malayi Probable ClpP-like protease 0.0175 0.0183 0.1521
Loa Loa (eye worm) patched family protein 0.0052 0.004 0.0321
Schistosoma mansoni hypothetical protein 0.0355 0.0393 0.0647
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0059 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.0243 1
Brugia malayi hypothetical protein 0.0052 0.004 0.0327
Echinococcus granulosus lysine specific demethylase 5A 0.0204 0.0217 0.0357
Trichomonas vaginalis penicillin-binding protein, putative 0.0226 0.0243 0.2881
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0859 0.0979 1
Brugia malayi acetyltransferase, GNAT family protein 0.0301 0.033 0.2753
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0004 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0199 0.0211 0.0211
Echinococcus multilocularis jumonji domain containing 1A 0.0053 0.0041 0.0041
Echinococcus granulosus beta LACTamase domain containing family member 0.0226 0.0243 0.04
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 0.0319
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0028 0.0782
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.0064 0.0104
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0092 0.0087 0.015
Brugia malayi Niemann-Pick C1 protein precursor 0.0859 0.0979 0.8179
Onchocerca volvulus Protein patched homolog 0.0052 0.004 0.0255
Brugia malayi Patched related family protein 4 0.0052 0.004 0.0327
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.0064 0.0517
Echinococcus granulosus Niemann Pick C1 protein 0.1227 0.1408 0.2317
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0092 0.0087 0.0718
Brugia malayi TAR-binding protein 0.0215 0.023 0.1918
Echinococcus granulosus heat shock protein 90 0.0031 0.0016 0.0026
Mycobacterium tuberculosis Conserved protein 0.0226 0.0243 0.0424
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0092 0.0087 0.015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Brugia malayi DnaJ domain containing protein 0.0061 0.0051 0.0418
Schistosoma mansoni tar DNA-binding protein 0.0215 0.023 0.0379
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Echinococcus multilocularis endoplasmin 0.0025 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.0064 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0044 0.0031 0.036
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0016 0.0624
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0002 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0226 0.0243 0.0424
Schistosoma mansoni ap endonuclease 0.0057 0.0046 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0186
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0092 0.0087 0.3545
Leishmania major hypothetical protein, conserved 0.0053 0.0041 0.1169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0222 0.0238 0.0415
Echinococcus multilocularis survival motor neuron protein 1 0.1046 0.1197 0.1197
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0092 0.0087 0.3545
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0004 0.0026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.0064 0.0104
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0092 0.0087 0.0861
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0028 0.032
Schistosoma mansoni cpg binding protein 0.0062 0.0052 0.0086
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0092 0.0087 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0222 0.0238 0.0415
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0314 0.0345 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0064 0.0523
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0114 0.0113 0.0196
Loa Loa (eye worm) hypothetical protein 0.0226 0.0243 0.2019
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.0121 0.021
Brugia malayi AMP-binding enzyme family protein 0.0314 0.0345 0.2875
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0002 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0072 0.0064 0.0064
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0023 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0314 0.0345 0.0603
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0009 0.0091
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0281 0.333
Echinococcus multilocularis peptidase Clp (S14 family) 0.0114 0.0113 0.0113
Echinococcus multilocularis heat shock protein 90 0.0031 0.0016 0.0016
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0019 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.0064 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0019 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Entamoeba histolytica hypothetical protein 0.0238 0.0257 0.2601
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0059 0.0059
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 0.723
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0114 0.0113 0.0196
Loa Loa (eye worm) patched family protein 0.0052 0.004 0.0321
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Loa Loa (eye worm) hypothetical protein 0.0053 0.0041 0.033
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.0064 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0247
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0092 0.0087 0.015
Brugia malayi Inositol-1 0.0042 0.0028 0.0225
Leishmania major pantothenate kinase subunit, putative 0.0024 0.0008 0.0202
Schistosoma mansoni hypothetical protein 0.0355 0.0393 0.0647
Onchocerca volvulus 0.0052 0.004 0.0255
Schistosoma mansoni bromodomain containing protein 0.0072 0.0063 0.0104
Plasmodium falciparum replication factor C subunit 1, putative 0.0044 0.0031 0.1204
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0004 0.0004
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0019 0.0738
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0041 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.0064 0.054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0046 0.0076
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0019 0.0146
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0092 0.0087 0.015
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0003 0.0049
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0016 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.0064 0.0523
Schistosoma mansoni protein phosphatase 2C 0.0053 0.0041 0.0068
Schistosoma mansoni hypothetical protein 0.0395 0.044 0.0723
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0072 0.0064 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Schistosoma mansoni acetyl-CoA synthetase 0.0092 0.0087 0.0143
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0016 0.0624
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0281 0.333
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0188 0.2224
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0089 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.006 0.005 0.2672
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0167 0.0173 0.1441
Plasmodium falciparum endoplasmin, putative 0.0019 0.0002 0.0038
Brugia malayi DKFZp564C0469 protein 0.0044 0.0031 0.0253
Schistosoma mansoni zinc finger protein 0.0034 0.0019 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0031 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0031 0.036
Loa Loa (eye worm) DR-78 0.0034 0.0019 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0281 0.333
Brugia malayi steroid hormone receptor 0.0072 0.0064 0.0523
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0136 0.0238
Schistosoma mansoni transcription factor btf3 0.0034 0.0019 0.0031
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0028 0.0028
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.017 0.017
Mycobacterium ulcerans hypothetical protein 0.0314 0.0345 0.0603
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0013 0.0482
Echinococcus granulosus Protein patched homolog 1 0.0369 0.0409 0.0672
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0188 0.2224
Brugia malayi hypothetical protein 0.0238 0.0257 0.2137
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Brugia malayi heat shock protein 90 0.0031 0.0016 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.0064 0.0523
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0175
Echinococcus granulosus endoplasmin 0.0025 0.0009 0.0014
Onchocerca volvulus 0.0094 0.0089 0.0855
Schistosoma mansoni topbp1 0.0044 0.0031 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0238 0.0257 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0046 0.2499
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0044 0.0031 0.0293
Mycobacterium tuberculosis Conserved protein 0.0226 0.0243 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0203 0.0334
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0004 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0064 0.0523
Echinococcus multilocularis JmjC domain containing protein 4 0.0053 0.0041 0.0041
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0013 0.0482
Plasmodium falciparum JmjC domain-containing protein, putative 0.0053 0.0041 0.1599
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0087 0.015
Plasmodium vivax endoplasmin, putative 0.0031 0.0016 0.06
Schistosoma mansoni jumonji/arid domain-containing protein 0.0204 0.0217 0.0357
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0059 0.0097
Loa Loa (eye worm) hypothetical protein 0.0044 0.0031 0.0247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0222 0.0238 0.0415
Schistosoma mansoni phosphatidylserine receptor 0.0053 0.0041 0.0068
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0092 0.0087 0.015
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0085 0.0146
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0003 0.007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0024 0.0192
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0024 0.0192
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0009 0.0316
Brugia malayi hypothetical protein 0.0019 0.0001 0.0002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0019 0.0152
Brugia malayi jmjC domain containing protein 0.0204 0.0217 0.1804
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0089 0.0089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0046 0.1878
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0003 0.0004
Plasmodium falciparum lipid/sterol:H+ symporter 0.0052 0.004 0.1557
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0003 0.0003
Echinococcus multilocularis GPCR, family 2 0.0167 0.0173 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.0121 0.021
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Plasmodium vivax SET domain protein, putative 0.0094 0.0089 0.3515
Loa Loa (eye worm) oxidoreductase 0.0092 0.0087 0.0712
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0059 0.0097
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0085 0.3322
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0009 0.0421
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Loa Loa (eye worm) hypothetical protein 0.0314 0.0345 0.2871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0064 0.0104
Schistosoma mansoni alpha glucosidase 0.0036 0.0022 0.0036
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0087 0.0718
Schistosoma mansoni peptidase Clp (S14 family) 0.0175 0.0183 0.0301
Schistosoma mansoni hypothetical protein 0.0213 0.0228 0.0375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0003 0.007
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0016 0.0026
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0002 0.0001
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0019 0.0738
Toxoplasma gondii patched family protein 0.0052 0.004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0053 0.0041 0.033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0004 0.0004
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0003 0.0004
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0011 0.0018
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.492 0.5708 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0314 0.0345 0.0603
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0009 0.1057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0109 0.0179
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.0243 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0046 0.1322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0059 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0013 0.0501
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0009 0.0316
Echinococcus granulosus expressed conserved protein 0.0807 0.0919 0.1511
Schistosoma mansoni coup transcription factor 0.0072 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0235 0.0253 0.2098
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.0157 0.0259
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0046 0.1807
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0624
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0064 0.0523
Loa Loa (eye worm) beta-lactamase 0.0226 0.0243 0.2019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.0203 0.1691
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0167 0.0173 0.0285
Loa Loa (eye worm) hypothetical protein 0.0226 0.0243 0.2019
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0044 0.0031 0.0053
Brugia malayi nuclear receptor RXR 0.0034 0.0019 0.0152
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0167 0.0173 0.0285
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0064 0.0104
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.0121 0.0197
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0003 0.0072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.002 0.002
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0092 0.0087 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0004 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.0064 0.0517
Plasmodium vivax glutathione reductase, putative 0.0053 0.0041 0.1608
Loa Loa (eye worm) hypothetical protein 0.0044 0.0031 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0203 0.0203
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0092 0.0087 0.015
Schistosoma mansoni microtubule-associated protein tau 0.5239 0.6078 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0044 0.0031 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0046 0.1807
Echinococcus multilocularis tumor protein p63 0.1044 0.1195 0.1195
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Brugia malayi jmjC domain containing protein 0.0053 0.0041 0.0336
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0016 0.0624
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0092 0.0087 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0013 0.0501
Onchocerca volvulus 0.0153 0.0157 0.1682
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0439
Echinococcus multilocularis Niemann Pick C1 protein 0.0859 0.0979 0.0979
Echinococcus granulosus tar DNA binding protein 0.0215 0.023 0.0379
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Toxoplasma gondii hypothetical protein 0.0052 0.004 0.0069
Plasmodium vivax acyl-CoA synthetase, putative 0.0235 0.0253 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0004 0.0091
Leishmania major trypanothione reductase 0.0053 0.0041 0.1176
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.0064 0.0517
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0044 0.0031 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0651 0.0737 0.615
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0016 0.0137
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0003 0.0008
Onchocerca volvulus 0.0213 0.0228 0.2539
Echinococcus granulosus heat shock protein 0.0031 0.0016 0.0026
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0158 0.0158
Schistosoma mansoni alpha-glucosidase 0.0141 0.0143 0.0235
Brugia malayi beta-NAC-like protein 0.0034 0.0019 0.0149
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0059 0.1688
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0059 0.0102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0059 0.0102
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0314 0.0345 0.0603
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0019 0.0031
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0016 0.012
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0019 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0013 0.0482
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0004 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0167 0.0173 0.1436
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0031 0.036
Echinococcus multilocularis geminin 0.0515 0.0579 0.0579
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0041 0.033
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0028 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0019 0.0031
Echinococcus granulosus cpg binding protein 0.0062 0.0052 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0281 0.333
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0011 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.1046 0.1197 0.1969
Mycobacterium leprae conserved hypothetical protein 0.0226 0.0243 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.0064 0.0523
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0019 0.0031
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0049
Brugia malayi beta-lactamase family protein 0.0226 0.0243 0.2024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0028 0.0047
Echinococcus multilocularis heat shock protein 0.0031 0.0016 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0061 0.0051 0.0084
Brugia malayi tailless protein 0.0034 0.0019 0.0152
Leishmania major basic transcription factor 3a, putative 0.0034 0.0019 0.0519
Schistosoma mansoni topbp1 0.0044 0.0031 0.0051
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0022 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0046 0.0374
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1446 0.1663 0.2913
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0019 0.0213
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.0109 0.0179
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0064 0.0104
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0092 0.0087 0.0712
Onchocerca volvulus 0.0092 0.0087 0.0823
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0004 0.0129
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0199 0.0211 0.0347
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0092 0.0087 0.015
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0022 0.0036
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0011 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0031 0.036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0024 0.0024
Brugia malayi Pre-SET motif family protein 0.0651 0.0737 0.6152
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0281 0.2335
Trypanosoma brucei unspecified product 0.0021 0.0004 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0019 0.0031
Echinococcus granulosus heat shock protein 90 0.0025 0.0009 0.0014
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0073 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0226 0.0243 0.2019
Toxoplasma gondii thioredoxin reductase 0.0053 0.0041 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0046 0.0371
Brugia malayi nuclear receptor RXR 0.0038 0.0024 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0177 0.2097
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0092 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.004 0.0321
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0016 0.0624
Mycobacterium ulcerans lipase LipD 0.0226 0.0243 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0024 0.0186
Onchocerca volvulus 0.0226 0.0243 0.2723
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0044 0.0031 0.036
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0092 0.0087 0.015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0064 0.0523
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0004 0.0129
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0314 0.0345 0.0603
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0084 0.0138
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0092 0.0087 0.3412
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0175 0.0183 0.723
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.017 0.0279
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.492 0.5708 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0085 0.0995
Brugia malayi hypothetical protein 0.0052 0.004 0.0327
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0004 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0314 0.0345 0.0603
Brugia malayi Patched family protein 0.0052 0.004 0.0327
Schistosoma mansoni hypothetical protein 0.0355 0.0393 0.0647
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0019 0.0019
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0019 0.0019
Onchocerca volvulus 0.0314 0.0345 0.3962
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0215 0.023 0.0379
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.0087 0.015
Schistosoma mansoni hypothetical protein 0.0167 0.0173 0.0285
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0044 0.0031 0.0053
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.0121 0.021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0175 0.0183 0.0306
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0226 0.0243 0.0424
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0028 0.1112
Brugia malayi jmjC domain containing protein 0.0053 0.0041 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.0064 0.0523
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0092 0.0087 0.0718
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0002 0.0031
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.0064 0.0104
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0041 0.0068
Leishmania major 4-coumarate:coa ligase-like protein 0.0314 0.0345 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0022 0.0247
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0004 0.0129
Brugia malayi jmjC domain containing protein 0.0053 0.0041 0.0336
Loa Loa (eye worm) glutathione reductase 0.0053 0.0041 0.0332
Brugia malayi RNA recognition motif domain containing protein 0.0215 0.023 0.1918
Echinococcus granulosus dnaJ subfamily B 0.0395 0.044 0.0723
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0235 0.0253 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0019 0.0213
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0092 0.0087 0.015
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0072 0.0064 0.0517
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0028 0.0258
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.017 0.1404
Loa Loa (eye worm) acetyltransferase 0.0301 0.033 0.2749
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0238 0.0257 0.0422
Giardia lamblia DINP protein human, muc B family 0.0021 0.0004 0.043
Loa Loa (eye worm) hypothetical protein 0.0092 0.0087 0.0712
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.0203 0.1686
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0092 0.0087 0.3545

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5805 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.92 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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