Detailed information for compound 153754

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 618.626 | Formula: C33H31F3N5O4+
  • H donors: 3 H acceptors: 3 LogP: 5.23 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.COc1cccc2c1cc(n2Cc1cccc(c1)C(=N)N)C(=O)NCc1ccc(cc1)c1cc[n+](cc1)C
  • InChi: 1S/C31H29N5O2.C2HF3O2/c1-35-15-13-24(14-16-35)23-11-9-21(10-12-23)19-34-31(37)28-18-26-27(7-4-8-29(26)38-2)36(28)20-22-5-3-6-25(17-22)30(32)33;3-2(4,5)1(6)7/h3-18H,19-20H2,1-2H3,(H3-,32,33,34,37);(H,6,7)/p+1
  • InChiKey: QCLABKKZWHTHLG-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0083 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.0678 0.06
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.0276 0.0259
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0111 0.0528 0.0507
Brugia malayi TAR-binding protein 0.0136 0.0687 0.0667
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0197 0.0197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0083 0.0036
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0479 0.0458
Brugia malayi N-terminal motif family protein 0.0051 0.0145 0.0124
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0076 0.0305 0.0288
Schistosoma mansoni hypothetical protein 0.0071 0.0276 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2436 0.24
Schistosoma mansoni tubulin subunit alpha 0.1201 0.7438 0.7433
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0357 0.2091 0.2054
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.0276 0.0259
Loa Loa (eye worm) hypothetical protein 0.0332 0.1931 0.1931
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni inositol monophosphatase 0.0041 0.0083 0.0062
Trypanosoma brucei beta tubulin 0.1604 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0479 0.0338
Mycobacterium leprae Conserved hypothetical protein 0.0051 0.0145 0.0512
Echinococcus multilocularis sex peptide receptor 0.0071 0.0276 0.0255
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0276 0.0255
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0276 0.0259
Loa Loa (eye worm) BEN-1 protein 0.1604 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0981 0.6046 0.6046
Trichomonas vaginalis tubulin epsilon chain, putative 0.1201 0.7438 0.7426
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0479 0.0433
Leishmania major beta tubulin 0.1604 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.1201 0.7438 0.7433
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0051 0.0145 0.0124
Schistosoma mansoni eyes absent homolog 0.0096 0.0433 0.0413
Schistosoma mansoni tubulin subunit alpha 0.0412 0.2436 0.2419
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0051 0.0145 0.0124
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Brugia malayi tubulin alpha-2 chain 0.1201 0.7438 0.7433
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0276 0.0259
Echinococcus granulosus sex peptide receptor 0.0071 0.0276 0.0259
Schistosoma mansoni tubulin subunit beta 0.1604 1 1
Trypanosoma brucei tubulin delta chain 0.0922 0.5669 0.566
Schistosoma mansoni amine GPCR 0.0071 0.0276 0.0255
Toxoplasma gondii beta tubulin 0.1604 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0071 0.0276 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0151 0.013
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0383 0.2251 0.2234
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.0276 0.0259
Echinococcus granulosus hypothetical protein 0.0071 0.0276 0.0259
Plasmodium falciparum tubulin beta chain 0.1604 1 1
Echinococcus granulosus neuropeptide s receptor 0.0071 0.0276 0.0259
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0051 0.0145 0.0124
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0276 0.0259
Brugia malayi Tubulin alpha-2 chain 0.1201 0.7438 0.7433
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0145 0.0512
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0276 0.0255
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0678 0.0658
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0051 0.0145 0.0124
Echinococcus multilocularis tubulin alpha 1C chain 0.1201 0.7438 0.7433
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0276 0.0259
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0153 0.0132
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0051 0.0145 0.0124
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Onchocerca volvulus 0.0071 0.0276 0.0871
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Mycobacterium ulcerans transcriptional regulatory protein 0.0051 0.0145 0.0512
Schistosoma mansoni hypothetical protein 0.0035 0.0048 0.0026
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0319 0.0302
Trypanosoma brucei alpha tubulin 0.1201 0.7438 0.7433
Brugia malayi Cell division protein ftsZ 0.0412 0.2436 0.2419
Trypanosoma brucei protein kinase A regulatory subunit 0.0051 0.0145 0.0124
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0083 0.0062
Echinococcus multilocularis tubulin alpha chain 0.1201 0.7438 0.7433
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0051 0.0145 0.0512
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0276 0.0259
Onchocerca volvulus 0.0071 0.0276 0.0871
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0276 0.0259
Loa Loa (eye worm) tubulin beta-4 chain 0.1604 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0276 0.0259
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0051 0.0145 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0145 0.0124
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0051 0.0145 0.0124
Schistosoma mansoni histamine h1 receptor 0.0071 0.0276 0.0255
Echinococcus granulosus tubulin alpha chain 0.1201 0.7438 0.7434
Mycobacterium ulcerans hypothetical protein 0.0051 0.0145 0.0512
Toxoplasma gondii beta-1 tubulin, putative 0.1604 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus fmrfamide receptor 0.0071 0.0276 0.0259
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) alpha-tubulin 0.1201 0.7438 0.7438
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0197 0.0176
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0051 0.0145 0.0128
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0051 0.0145 0.012
Schistosoma mansoni hypothetical protein 0.0071 0.0276 0.0255
Trypanosoma brucei beta tubulin 0.1604 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0479 0.0479
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.0276 0.0255
Echinococcus granulosus cGMP dependent protein kinase 1 0.0051 0.0151 0.0134
Leishmania major beta tubulin 0.1604 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.0276 0.0255
Giardia lamblia Epsilon tubulin 0.0493 0.2952 0.2848
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0687 0.0687
Echinococcus granulosus tubulin epsilon chain 0.098 0.6038 0.6031
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0207 0.0186
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0276 0.0255
Brugia malayi Inositol-1 0.0041 0.0083 0.0062
Echinococcus granulosus Tubulin beta 2C chain 0.1604 1 1
Echinococcus granulosus g-protein coupled receptor 0.0071 0.0276 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0051 0.0145 0.0512
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0051 0.0151 0.013
Leishmania major beta tubulin 0.1604 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0789 0.4827 0.4802
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0276 0.0276
Leishmania major protein kinase, putative 0.0051 0.0151 0.013
Brugia malayi Muscleblind-like protein 0.0163 0.0857 0.0837
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0051 0.0145 0.0145
Loa Loa (eye worm) tubulin alpha-2 chain 0.1201 0.7438 0.7438
Mycobacterium ulcerans transmembrane transport protein 0.0051 0.0145 0.0512
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.0276 0.0276
Plasmodium vivax delta tubulin, putative 0.0412 0.2436 0.2417
Schistosoma mansoni neuropeptide receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis hyperpolarization activated cyclic 0.0076 0.0305 0.0284
Trichomonas vaginalis tubulin epsilon chain, putative 0.1604 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0153 0.0132
Echinococcus granulosus tubulin alpha chain 0.1201 0.7438 0.7434
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0479 0.0458
Loa Loa (eye worm) tubulin beta chain 0.0412 0.2436 0.2436
Schistosoma mansoni alpha tubulin 0.1201 0.7438 0.7433
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0153 0.0153
Schistosoma mansoni voltage-gated potassium channel 0.0418 0.2474 0.2458
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0051 0.0145 0.0124
Leishmania major beta tubulin 0.1604 1 1
Echinococcus granulosus alpha tubulin 0.1201 0.7438 0.7434
Trichomonas vaginalis tubulin beta chain, putative 0.1201 0.7438 0.7426
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0305 0.0284
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0197 0.0197
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0076 0.0305 0.0284
Brugia malayi follicle stimulating hormone receptor 0.0297 0.1708 0.169
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0145 0.0512
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus tubulin delta chain 0.0412 0.2436 0.2422
Schistosoma mansoni alpha tubulin 0.1201 0.7438 0.7433
Loa Loa (eye worm) beta-tubulin 0.1604 1 1
Trypanosoma brucei beta tubulin 0.1604 1 1
Echinococcus multilocularis orexin receptor type 2 0.0071 0.0276 0.0255
Echinococcus granulosus voltage gated potassium channel 0.0111 0.0528 0.0511
Brugia malayi Pre-SET motif family protein 0.022 0.1221 0.1202
Onchocerca volvulus 0.0071 0.0276 0.0871
Leishmania major hypothetical protein, conserved 0.0051 0.0145 0.0124
Brugia malayi Tubulin alpha-2 chain 0.1201 0.7438 0.7433
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0051 0.0145 0.012
Echinococcus multilocularis peroxisome assembly protein 26 0.1201 0.7438 0.7433
Schistosoma mansoni amine GPCR 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0163 0.0857 0.0857
Brugia malayi Pre-SET motif family protein 0.0032 0.0025 0.0004
Schistosoma mansoni neuropeptide receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0789 0.4827 0.4827
Echinococcus multilocularis Tubulin beta 2C chain 0.1604 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0479 0.0458
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0479 0.0458
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus multilocularis beta tubulin 0.1604 1 1
Brugia malayi MAP kinase sur-1 0.0103 0.0479 0.0458
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Trypanosoma brucei zeta tubulin, putative 0.1264 0.7841 0.7836
Echinococcus multilocularis allatostatin A receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Entamoeba histolytica tubulin alpha-1 chain 0.1201 0.7438 0.7417
Loa Loa (eye worm) tubulin alpha chain 0.1201 0.7438 0.7438
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1201 0.7438 0.7426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0153 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus multilocularis tubulin alpha chain 0.1201 0.7438 0.7433
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0479 0.0458
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0096 0.0433 0.0433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0276 0.0255
Entamoeba histolytica tubulin family protein 0.1604 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0051 0.0145 0.0124
Giardia lamblia Beta tubulin 0.1604 1 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0051 0.0145 0.0124
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis tubulin alpha 0.0898 0.5523 0.5513
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.0276 0.0255
Schistosoma mansoni 60S ribosomal protein L21 0.006 0.0207 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0479 0.0433
Echinococcus multilocularis tubulin gamma 1 chain 0.0981 0.6046 0.6038
Trypanosoma cruzi tubulin delta chain 0.0922 0.5669 0.566
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0678 0.0662
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0197 0.0176
Trichomonas vaginalis tubulin, putative 0.1604 1 1
Echinococcus granulosus g protein coupled receptor 0.0071 0.0276 0.0259
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0051 0.0145 0.0124
Schistosoma mansoni alpha tubulin 0.1201 0.7438 0.7433
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0276 0.0276
Echinococcus granulosus hyperpolarization activated cyclic 0.0076 0.0305 0.0288
Schistosoma mansoni tubulin subunit alpha 0.1201 0.7438 0.7433
Loa Loa (eye worm) RNA binding protein 0.0136 0.0687 0.0687
Trichomonas vaginalis tubulin, putative 0.0487 0.2911 0.2878
Echinococcus multilocularis Tubulin alpha 1 chain 0.1201 0.7438 0.7433
Loa Loa (eye worm) AGC/PKG protein kinase 0.0051 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.0276 0.0871
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Loa Loa (eye worm) hypothetical protein 0.1201 0.7438 0.7438
Echinococcus granulosus Tubulin beta 2C chain 0.1604 1 1
Schistosoma mansoni adenoreceptor 0.0071 0.0276 0.0255
Brugia malayi Tubulin alpha chain 0.0412 0.2436 0.2419
Echinococcus multilocularis tubulin beta 1 chain 0.1604 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0479 0.0458
Brugia malayi G-protein coupled receptor 0.0071 0.0276 0.0255
Brugia malayi Dopamine receptor protein 2 0.0071 0.0276 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0687 0.0667
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0051 0.0151 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0076 0.0305 0.0284
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0051 0.0145 0.0416
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0276 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Leishmania major beta tubulin 0.1604 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0479 0.0433
Loa Loa (eye worm) cytochrome P450 family protein 0.0095 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0096 0.0433 0.0433
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0678 0.0658
Onchocerca volvulus 0.0071 0.0276 0.0871
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0083 0.0255
Echinococcus granulosus neuropeptide receptor 0.0071 0.0276 0.0259
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.0276 0.0255
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Trypanosoma cruzi cAMP binding protein, putative 0.0051 0.0145 0.0124
Onchocerca volvulus 0.0071 0.0276 0.0871
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0035 0.0048 0.0026
Schistosoma mansoni tubulin subunit beta 0.1604 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0528 0.0507
Echinococcus granulosus Tubulin beta 2C chain 0.1604 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0153 0.0132
Loa Loa (eye worm) hypothetical protein 0.0163 0.0857 0.0857
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0051 0.0145 0.0124
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0922 0.5669 0.566
Plasmodium vivax tubulin gamma chain, putative 0.0981 0.6046 0.6036
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0493 0.2952 0.2936
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0678 0.0658
Echinococcus multilocularis tubulin subunit TubB 0.1201 0.7438 0.7433
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Toxoplasma gondii alpha-tubulin I, putative 0.1201 0.7438 0.7433
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0076 0.0305 0.0284
Schistosoma mansoni tubulin subunit beta 0.1604 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0487 0.2911 0.2878
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0145
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0276 0.0255
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.0276 0.0259
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0383 0.2251 0.2234
Echinococcus granulosus peroxisome assembly protein 26 0.1201 0.7438 0.7434
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0197 0.0197
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0276 0.0255
Trichomonas vaginalis tubulin gamma chain, putative 0.098 0.6038 0.6019
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0678 0.0658
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1221 0.1221
Schistosoma mansoni amine GPCR 0.0071 0.0276 0.0255
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Loa Loa (eye worm) tubulin alpha-3 chain 0.0714 0.4351 0.4351
Echinococcus granulosus tubulin alpha 1C chain 0.1201 0.7438 0.7434
Loa Loa (eye worm) tubulin alpha 2 0.0789 0.4827 0.4827
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0479 0.0458
Giardia lamblia Delta tubulin 0.0412 0.2436 0.2324
Onchocerca volvulus 0.0071 0.0276 0.0871
Leishmania major hypothetical protein, conserved 0.0051 0.0145 0.0124
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Leishmania major beta tubulin 0.1604 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Treponema pallidum cell division protein FtsZ 0.0412 0.2436 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0025 0.0007
Schistosoma mansoni tubulin subunit gamma 0.0981 0.6046 0.6038
Onchocerca volvulus 0.0071 0.0276 0.0871
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.0276 0.0276
Echinococcus multilocularis tubulin delta chain 0.0412 0.2436 0.2419
Trypanosoma cruzi zeta tubulin, putative 0.1264 0.7841 0.7836
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0051 0.0151 0.013
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0687 0.0687
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0276 0.0255
Trypanosoma brucei protein kinase, putative 0.0103 0.0479 0.0458
Brugia malayi ORL1-like opioid receptor 0.0071 0.0276 0.0255
Onchocerca volvulus 0.0071 0.0276 0.0871
Plasmodium vivax tubulin epsilon chain, putative 0.098 0.6038 0.6028
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Entamoeba histolytica tubulin alpha chain, putative 0.1201 0.7438 0.7417
Echinococcus multilocularis Tubulin beta 2C chain 0.1604 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.1201 0.7438 0.7426
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Trypanosoma brucei beta tubulin 0.0898 0.5523 0.5513
Plasmodium falciparum tubulin gamma chain 0.0981 0.6046 0.5988
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0276 0.0259
Brugia malayi RE15519p 0.0071 0.0276 0.0255
Leishmania major regulatory subunit of protein kinase a-like protein 0.0051 0.0145 0.0124
Brugia malayi AKH receptor 0.0071 0.0276 0.0255
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0056 0.0143
Giardia lamblia Beta tubulin 0.1604 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Brugia malayi Tubulin gamma chain 0.0981 0.6046 0.6038
Mycobacterium ulcerans cell division protein FtsZ 0.0412 0.2436 1
Schistosoma mansoni opsin-like receptor 0.0071 0.0276 0.0255
Trypanosoma cruzi Flagellar Member 6 0.0051 0.0145 0.0124
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0678 0.0658
Brugia malayi hypothetical protein 0.0096 0.0433 0.0413
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0025 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0297 0.1708 0.1708
Loa Loa (eye worm) tubulin alpha 2 0.0302 0.174 0.174
Leishmania major protein kinase, putative 0.0051 0.0151 0.013
Trypanosoma brucei cAMP binding protein, putative 0.0051 0.0145 0.0124
Echinococcus granulosus g protein coupled receptor 0.0071 0.0276 0.0259
Echinococcus multilocularis tubulin alpha 3 chain 0.1201 0.7438 0.7433
Trypanosoma cruzi cAMP response protein 1 0.0051 0.0145 0.0124
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0197 0.0726
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0051 0.0145 0.0124
Leishmania major cytochrome p450-like protein 0.0059 0.0197 0.0176
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.0276 0.0276
Leishmania major beta tubulin 0.1604 1 1
Loa Loa (eye worm) hypothetical protein 0.0714 0.4351 0.4351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0276 0.0255
Echinococcus granulosus Tubulin beta 2C chain 0.1604 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0898 0.5523 0.5513
Trichomonas vaginalis tubulin, putative 0.0494 0.2959 0.2926
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0276 0.0255
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0051 0.0145 0.0098
Echinococcus granulosus tubulin beta 1 chain 0.1604 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1604 1 1
Leishmania major delta tubulin, putative 0.0922 0.5669 0.566
Echinococcus multilocularis muscleblind protein 0.0163 0.0857 0.0837
Loa Loa (eye worm) BEN-1 protein 0.1604 1 1
Trypanosoma cruzi protein kinase A regulatory subunit 0.0051 0.0145 0.0124
Entamoeba histolytica tubulin family protein 0.1604 1 1
Echinococcus granulosus beta tubulin 0.1604 1 1
Giardia lamblia Gamma tubulin 0.0981 0.6046 0.5988
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0083 0.0036
Loa Loa (eye worm) hypothetical protein 0.0789 0.4827 0.4827
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0153 0.0132
Trypanosoma brucei Flagellar Member 6 0.0051 0.0145 0.0124
Brugia malayi G-protein coupled receptor 0.0071 0.0276 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0687 0.0667
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0687 0.0667
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0051 0.0145 0.0124
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis tubulin alpha 1C chain 0.1201 0.7438 0.7433
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.0276 0.0255
Schistosoma mansoni neuropeptide receptor 0.0071 0.0276 0.0255
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0051 0.0145 0.0124
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0051 0.0145 0.0124
Brugia malayi neuropeptide F receptor 0.0071 0.0276 0.0255
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0051 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Trypanosoma brucei alpha tubulin 0.1201 0.7438 0.7433
Leishmania major beta tubulin 0.1604 1 1
Echinococcus multilocularis tubulin epsilon chain 0.098 0.6038 0.603
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.0276 0.0255
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0412 0.2436 0.24
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0083 0.0062
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis tubulin alpha chain 0.1201 0.7438 0.7433
Leishmania major gamma-tubulin 0.0981 0.6046 0.6038
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0479 0.0462
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0051 0.0145 0.0512
Echinococcus multilocularis tubulin alpha chain 0.1201 0.7438 0.7433
Leishmania major beta tubulin 0.1604 1 1
Echinococcus multilocularis serotonin receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0276 0.0255
Echinococcus granulosus tubulin alpha 3 chain 0.1201 0.7438 0.7434
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Echinococcus multilocularis hyperpolarization activated cyclic 0.0076 0.0305 0.0284
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.0276 0.0255
Brugia malayi Dopamine receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Schistosoma mansoni hypothetical protein 0.0071 0.0276 0.0255
Loa Loa (eye worm) alpha-tubulin 0.1201 0.7438 0.7438
Trypanosoma brucei beta tubulin 0.1604 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0276 0.0276
Trypanosoma brucei alpha tubulin 0.1201 0.7438 0.7433
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0479 0.0433
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0276 0.0276
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0276 0.0255
Leishmania major beta tubulin 0.1604 1 1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0083 0.0062
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1414 0.1373
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0051 0.0145 0.0124
Trichomonas vaginalis tubulin beta chain, putative 0.1201 0.7438 0.7426
Toxoplasma gondii alpha tubulin TUBA1 0.1201 0.7438 0.7433
Leishmania major zeta tubulin, putative 0.1264 0.7841 0.7836
Brugia malayi putative neuropeptide receptor 0.0071 0.0276 0.0255
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0276 0.0255
Onchocerca volvulus 0.0071 0.0276 0.0871
Brugia malayi G protein-coupled receptor 0.0071 0.0276 0.0255
Schistosoma mansoni myosin xvIII 0.0071 0.0276 0.0255
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0479 0.0458
Echinococcus granulosus Tubulin alpha 1 chain 0.1201 0.7438 0.7434
Loa Loa (eye worm) tubulin alpha chain 0.1201 0.7438 0.7438
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0051 0.0145 0.0124
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.0276 0.0871
Echinococcus granulosus allatostatin A receptor 0.0071 0.0276 0.0259
Plasmodium falciparum alpha tubulin 1 0.1201 0.7438 0.7401
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.0276 0.0259
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0051 0.0145 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Brugia malayi Cytochrome P450 family protein 0.0059 0.0197 0.0176
Schistosoma mansoni opsin-like receptor 0.0071 0.0276 0.0255
Brugia malayi larval opioid receptor 0.0071 0.0276 0.0255
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0051 0.0145 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Onchocerca volvulus 0.0071 0.0276 0.0871
Trypanosoma brucei epsilon tubulin 0.098 0.6038 0.603
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0305 0.0284
Leishmania major beta tubulin 0.1604 1 1
Trypanosoma brucei alpha tubulin 0.1201 0.7438 0.7433
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0276 0.0255
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis beta tubulin 0.1604 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0276 0.0259
Entamoeba histolytica tubulin gamma chain 0.0981 0.6046 0.6013
Echinococcus granulosus tubulin alpha 1C chain 0.1201 0.7438 0.7434
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0151 0.013
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0071 0.0276 0.0255
Onchocerca volvulus 0.0071 0.0276 0.0871
Toxoplasma gondii beta-tubulin, putative 0.1604 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.098 0.6038 0.603
Brugia malayi Tubulin beta chain 0.0487 0.2911 0.2896
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0383 0.2251 0.2237
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0276 0.0255
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0276 0.0255
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0076 0.0305 0.0288
Trypanosoma cruzi epsilon tubulin, putative 0.098 0.6038 0.603
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0151 0.013
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0687 0.0667
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Trichomonas vaginalis tubulin alpha chain, putative 0.0487 0.2911 0.2878
Echinococcus granulosus muscleblind protein 0.0163 0.0857 0.084
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.0276 0.0259
Plasmodium vivax tubulin alpha chain, putative 0.1201 0.7438 0.7432
Leishmania major beta tubulin 0.1604 1 1
Echinococcus multilocularis hypothetical protein 0.1201 0.7438 0.7433
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0051 0.0145 0.0098
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.0276 0.0255
Leishmania major cyclic nucleotide-binding protein-like protein 0.0051 0.0145 0.0124
Loa Loa (eye worm) inositol-1 0.0041 0.0083 0.0083
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0022 0.0004
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0051 0.0145 0.0128
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.0276 0.0255
Leishmania major epsilon tubulin, putative 0.098 0.6038 0.603
Echinococcus granulosus hyperpolarization activated cyclic 0.0076 0.0305 0.0288
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0083 0.0036
Brugia malayi Dopamine receptor protein 1 0.0071 0.0276 0.0255
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0051 0.0145 0.0098
Trypanosoma cruzi zeta tubulin, putative 0.1264 0.7841 0.7836
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Trichomonas vaginalis tubulin epsilon chain, putative 0.1201 0.7438 0.7426
Brugia malayi Cytochrome P450 family protein 0.0059 0.0197 0.0176
Trichomonas vaginalis tubulin beta chain, putative 0.1604 1 1
Brugia malayi RNA binding protein 0.0136 0.0687 0.0667
Brugia malayi Tubulin alpha chain 0.1201 0.7438 0.7433
Onchocerca volvulus 0.0071 0.0276 0.0871
Plasmodium falciparum cGMP-dependent protein kinase 0.0051 0.0151 0.0006
Mycobacterium tuberculosis Cell division protein FtsZ 0.0412 0.2436 1
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2436 0.24
Echinococcus granulosus Tubulin alpha 1 chain 0.1201 0.7438 0.7434
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.0276 0.0259
Echinococcus granulosus somatostatin receptor 0.0071 0.0276 0.0259
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0076 0.0305 0.0305
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.0276 0.0255
Echinococcus granulosus single minded 2 0.0035 0.0048 0.003
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0487 0.2911 0.2878
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0687 0.0667
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0687 0.0667
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Giardia lamblia Alpha-tubulin 0.1201 0.7438 0.7401
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Trichomonas vaginalis tubulin alpha chain, putative 0.1604 1 1
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0528 0.0507
Echinococcus granulosus g protein coupled receptor 0.0071 0.0276 0.0259
Trichomonas vaginalis tubulin gamma chain, putative 0.0412 0.2436 0.24
Plasmodium falciparum tubulin epsilon chain, putative 0.098 0.6038 0.598
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0714 0.4351 0.4324
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0276 0.0259
Schistosoma mansoni hypothetical protein 0.0051 0.0145 0.0124
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0051 0.0145 0.0128
Trichomonas vaginalis tubulin epsilon chain, putative 0.0412 0.2436 0.24
Trypanosoma cruzi beta tubulin, putative 0.1604 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0276 0.0255
Schistosoma mansoni biogenic amine receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.0276 0.0255
Trichomonas vaginalis tubulin, putative 0.0487 0.2911 0.2878
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0145
Trichomonas vaginalis tubulin beta chain, putative 0.0487 0.2911 0.2878
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0479 0.0458
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.0276 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.0276 0.0255
Leishmania major beta tubulin 0.1604 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0071 0.0276 0.0255
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0051 0.0145 0.0124
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0276 0.0259
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0076 0.0305 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0051 0.0145 0.0124
Loa Loa (eye worm) tubulin beta chain 0.1604 1 1
Trypanosoma brucei epsilon tubulin 0.0898 0.5523 0.5513
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0056 0.0143
Echinococcus multilocularis serotonin receptor 0.0071 0.0276 0.0255
Leishmania major protein kinase A regulatory subunit, putative 0.0051 0.0145 0.0124
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0076 0.0305 0.0305
Brugia malayi beta-tubulin, identical 0.1604 1 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0051 0.0145 0.0128
Schistosoma mansoni tubulin subunit beta 0.1604 1 1
Plasmodium vivax tubulin alpha chain, putative 0.1201 0.7438 0.7432
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0305 0.0284
Trichomonas vaginalis tubulin beta chain, putative 0.1201 0.7438 0.7426
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.0276 0.0255
Plasmodium falciparum alpha tubulin 2 0.1201 0.7438 0.7401
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus cGMP dependent protein kinase 1 0.0051 0.0151 0.0134
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0305 0.0258
Echinococcus granulosus tubulin beta 4A class IVa 0.1604 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni voltage-gated potassium channel 0.0418 0.2474 0.2458
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.0276 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0153 0.0135
Trypanosoma cruzi tubulin delta chain 0.0922 0.5669 0.566
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0051 0.0145 0.0512
Echinococcus granulosus tar DNA binding protein 0.0136 0.0687 0.0671
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.0276 0.0276
Trypanosoma brucei zeta tubulin 0.1264 0.7841 0.7836
Schistosoma mansoni tubulin subunit alpha 0.1201 0.7438 0.7433
Schistosoma mansoni hypothetical protein 0.0071 0.0276 0.0255
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0051 0.0145 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Echinococcus multilocularis Tubulin beta 2C chain 0.1604 1 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0412 0.2436 1
Echinococcus granulosus tubulin gamma 1 chain 0.0981 0.6046 0.6039
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0276 0.0259
Trypanosoma cruzi cAMP response protein 1, putative 0.0051 0.0145 0.0124
Toxoplasma gondii tubulin, putative 0.0081 0.0341 0.032
Mycobacterium leprae Possible transporter protein 0.0035 0.0048 0.0108
Loa Loa (eye worm) tubulin beta-1 chain 0.1604 1 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0083 0.0062
Trichomonas vaginalis tubulin epsilon chain, putative 0.1604 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0357 0.2091 0.2054
Brugia malayi Tubulin beta chain 0.0412 0.2436 0.2419
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0071 0.0276 0.0255
Echinococcus granulosus patatin phospholipase domain containing protein 0.0051 0.0145 0.0128
Echinococcus granulosus cGMP dependent protein kinase 0.0051 0.0151 0.0134
Loa Loa (eye worm) tubulin alpha 2 0.0789 0.4827 0.4827
Brugia malayi tubulin alpha chain - mouse 0.1201 0.7438 0.7433
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0319 0.0298
Echinococcus multilocularis tubulin alpha chain 0.1201 0.7438 0.7433
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0083 0.0062
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.0276 0.0259
Leishmania major hypothetical protein, conserved 0.0051 0.0145 0.0124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0153 0.0132
Trichomonas vaginalis tubulin beta chain, putative 0.1201 0.7438 0.7426
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0083 0.0062
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0076 0.0305 0.0288
Echinococcus granulosus beta tubulin 0.1604 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.0276 0.0255
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0305 0.0284
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0276 0.0255
Trypanosoma brucei epsilon tubulin 0.098 0.6038 0.603
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0111 0.0528 0.0507
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0051 0.0145 0.0124
Echinococcus granulosus Tubulin beta 2C chain 0.1604 1 1
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0276 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0145 0.0098
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0025 0.0004
Brugia malayi alpha-tubulin 0.1201 0.7438 0.7433
Leishmania major beta tubulin 0.1604 1 1
Onchocerca volvulus 0.0071 0.0276 0.0871
Trypanosoma cruzi tubulin gamma chain 0.0981 0.6046 0.6038
Leishmania major beta tubulin 0.1604 1 1
Leishmania major beta tubulin 0.1604 1 1
Schistosoma mansoni opsin-like receptor 0.0071 0.0276 0.0255
Giardia lamblia Alpha-tubulin 0.1201 0.7438 0.7401
Mycobacterium ulcerans hypothetical protein 0.0051 0.0145 0.0512
Schistosoma mansoni tubulin subunit beta 0.1604 1 1
Onchocerca volvulus 0.0071 0.0276 0.0871
Echinococcus granulosus tubulin alpha 3 chain 0.1201 0.7438 0.7434
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0479 0.0462
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0051 0.0145 0.0124
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0076 0.0305 0.0305
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Echinococcus multilocularis somatostatin receptor 0.0071 0.0276 0.0255
Trichomonas vaginalis tubulin alpha chain, putative 0.0487 0.2911 0.2878
Trypanosoma cruzi alpha tubulin, putative 0.1201 0.7438 0.7433
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0083 0.0062
Loa Loa (eye worm) tubulin beta-2A chain 0.1604 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0197 0.0176
Brugia malayi Melatonin receptor type 1A 0.0071 0.0276 0.0255
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0051 0.0145 0.0124
Echinococcus multilocularis Tubulin alpha 1 chain 0.1201 0.7438 0.7433
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.0276 0.0255
Brugia malayi Cytochrome P450 family protein 0.0095 0.0427 0.0406
Trypanosoma brucei alpha tubulin, putative 0.0487 0.2911 0.2896
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0678 0.0658
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Echinococcus granulosus tubulin subunit beta 0.1604 1 1
Onchocerca volvulus 0.0251 0.1414 0.4813
Echinococcus granulosus tubulin subunit TubB 0.1201 0.7438 0.7434
Brugia malayi neuropeptide F receptor 0.0071 0.0276 0.0255
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.0276 0.0255
Mycobacterium ulcerans hypothetical protein 0.0051 0.0145 0.0512
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0276 0.0255
Mycobacterium ulcerans regulatory protein 0.0051 0.0145 0.0512
Echinococcus multilocularis Tubulin beta 2C chain 0.1604 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.0276 0.0255
Trypanosoma brucei cAMP response protein 1, putative 0.0051 0.0145 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0153 0.0135
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0305 0.0284
Echinococcus granulosus tubulin alpha chain 0.1201 0.7438 0.7434
Plasmodium vivax tubulin beta chain, putative 0.1604 1 1
Brugia malayi GnHR receptor homolog 0.0071 0.0276 0.0255
Schistosoma mansoni tubulin subunit beta 0.1604 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.0276 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0276 0.0255
Brugia malayi Egg laying defective protein 4 0.0051 0.0151 0.013
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.0276 0.0255
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.0276 0.0255
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0036 0.0054 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.0276 0.0255
Mycobacterium ulcerans hypothetical protein 0.0051 0.0145 0.0512
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0111 0.0528 0.0511
Brugia malayi Cyclic-nucleotide gated cation channel 0.0076 0.0305 0.0284
Brugia malayi hypothetical protein 0.0071 0.0276 0.0255
Schistosoma mansoni tubulin subunit epsilon 0.098 0.6038 0.603
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0051 0.0145 0.0124
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0276 0.0255
Onchocerca volvulus 0.0051 0.0145 0.0416
Echinococcus multilocularis expressed conserved protein 0.0051 0.0151 0.013
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0305 0.0284
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.0276 0.0255
Trichomonas vaginalis tubulin gamma chain, putative 0.1604 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0383 0.2251 0.2251
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Giardia lamblia Beta tubulin 0.1604 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0981 0.6046 0.6027
Onchocerca volvulus 0.0071 0.0276 0.0871
Onchocerca volvulus 0.0051 0.0145 0.0416
Plasmodium falciparum tubulin delta chain, putative 0.0412 0.2436 0.2324
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus serotonin receptor 0.0071 0.0276 0.0259
Brugia malayi sulfakinin receptor protein 0.0071 0.0276 0.0255
Schistosoma mansoni biogenic amine receptor 0.0071 0.0276 0.0255
Leishmania major beta tubulin 0.1604 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0025 0.0004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0051 0.0145 0.0124
Echinococcus multilocularis voltage gated potassium channel 0.0111 0.0528 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0025 0.0004
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0051 0.0145 0.0098
Echinococcus granulosus tubulin alpha chain 0.1201 0.7438 0.7434
Schistosoma mansoni tubulin subunit delta 0.0412 0.2436 0.2419
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0479 0.0458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0004
Echinococcus granulosus tubulin alpha chain 0.1201 0.7438 0.7434
Trichomonas vaginalis tubulin alpha chain, putative 0.0898 0.5523 0.5501
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0305 0.0258
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0051 0.0145 0.0124
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0687 0.0667
Brugia malayi Serotonin receptor 0.0071 0.0276 0.0255
Echinococcus granulosus Tubulin alpha 1 chain 0.1201 0.7438 0.7434
Trichomonas vaginalis tubulin beta chain, putative 0.1201 0.7438 0.7426
Leishmania major alpha tubulin 0.1201 0.7438 0.7433
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0276 0.0259
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.0276 0.0259
Leishmania major beta tubulin 0.1604 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0276 0.0255
Schistosoma mansoni amine GPCR 0.0071 0.0276 0.0255
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0678 0.0658
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Brugia malayi Serotonin receptor 0.0071 0.0276 0.0255
Schistosoma mansoni tubulin subunit beta 0.0412 0.2436 0.2419
Echinococcus granulosus orexin receptor type 2 0.0071 0.0276 0.0259
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0276 0.0255
Trypanosoma brucei tubulin gamma chain 0.0981 0.6046 0.6038
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Leishmania major hypothetical protein, unknown function 0.0051 0.0145 0.0124
Schistosoma mansoni biogenic amine receptor 0.0071 0.0276 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0004
Echinococcus multilocularis tubulin subunit beta 0.1604 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0479 0.0458
Schistosoma mansoni neuropeptide receptor 0.0071 0.0276 0.0255
Onchocerca volvulus 0.0487 0.2911 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0528 0.0528
Echinococcus multilocularis tubulin alpha 3 chain 0.1201 0.7438 0.7433
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0051 0.0145 0.0124
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Onchocerca volvulus 0.0071 0.0276 0.0871
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0051 0.0145 0.0124
Mycobacterium tuberculosis Conserved protein 0.0051 0.0145 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0276 0.0255
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1604 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.0276 0.0255
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.0276 0.0259
Schistosoma mansoni amine GPCR 0.0071 0.0276 0.0255
Loa Loa (eye worm) cytochrome P450 0.0031 0.0022 0.0022
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0678 0.0678
Echinococcus granulosus neuropeptide receptor 0.0071 0.0276 0.0259
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0857 0.0837
Onchocerca volvulus 0.0071 0.0276 0.0871
Mycobacterium leprae cell division protein FtsZ 0.0412 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0276 0.0276
Echinococcus granulosus tubulin alpha 0.0898 0.5523 0.5515

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 110 nM Inhibition of Coagulation factor Xa ChEMBL. 12061878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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