Detailed information for compound 1546273

Basic information

Technical information
  • TDR Targets ID: 1546273
  • Name: 4-[bis(2-methoxyethyl)sulfamoyl]-N-(3-morphol in-4-ylpropyl)benzamide
  • MW: 443.558 | Formula: C20H33N3O6S
  • H donors: 1 H acceptors: 3 LogP: 0.07 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN(S(=O)(=O)c1ccc(cc1)C(=O)NCCCN1CCOCC1)CCOC
  • InChi: 1S/C20H33N3O6S/c1-27-14-12-23(13-15-28-2)30(25,26)19-6-4-18(5-7-19)20(24)21-8-3-9-22-10-16-29-17-11-22/h4-7H,3,8-17H2,1-2H3,(H,21,24)
  • InChiKey: PPRMCNFIOTZEDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[bis(2-methoxyethyl)sulfamoyl]-N-(3-morpholinopropyl)benzamide
  • MLS000057781
  • SMR000061803
  • T0511-6640

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0082 0.0174
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0082 0.0179
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.0004
Schistosoma mansoni wnt-5 0.0013 0.0021 0.0045
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0012 0.002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0082 0.0174
Onchocerca volvulus 0.0031 0.0077 0.0929
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Schistosoma mansoni vav2 0.0031 0.0077 0.0167
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0082 0.0174
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus multilocularis pdz domain containing protein 0.0031 0.0077 0.0162
Schistosoma mansoni zinc finger protein 0.0031 0.0077 0.0167
Plasmodium falciparum oxysterol-binding protein, putative 0.0031 0.0077 0.8138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Brugia malayi Pre-SET motif family protein 0.0206 0.0631 0.0625
Echinococcus multilocularis protein Wnt 2 0.0013 0.0021 0.004
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0031 0.0077 0.0162
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0082 0.0174
Onchocerca volvulus 0.0032 0.0082 0.1005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni opsin-like receptor 0.0032 0.0082 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0163
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0082 0.0167
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0052 0.0715
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Echinococcus granulosus allatostatin A receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni biogenic amine receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus granulosus pleckstrin y domain containing family A 0.0031 0.0077 0.0162
Toxoplasma gondii phosphatidylinositol transfer protein 0.0031 0.0077 0.4579
Loa Loa (eye worm) AGC/PKG protein kinase 0.001 0.0012 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0173 0.0381
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Echinococcus multilocularis protein Wnt 1 0.0013 0.0021 0.004
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Echinococcus granulosus oxysterol binding protein 1 0.0031 0.0077 0.0162
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0031 0.0077 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Brugia malayi hypothetical protein 0.0039 0.0102 0.0096
Echinococcus multilocularis GPCR, family 2 0.0034 0.0086 0.0182
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0082 0.0179
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Echinococcus granulosus beta 1 syntrophin 0.0031 0.0077 0.0162
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0021
Brugia malayi AKH receptor 0.0032 0.0082 0.0076
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Trypanosoma cruzi NIMA-related kinase, putative 0.0035 0.0091 0.3044
Echinococcus granulosus cpg binding protein 0.003 0.0074 0.0157
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0082 0.0174
Brugia malayi G-protein coupled receptor 0.0032 0.0082 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Brugia malayi ORL1-like opioid receptor 0.0032 0.0082 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Brugia malayi GnHR receptor homolog 0.0032 0.0082 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Leishmania major folate/biopterin transporter, putative 0.0035 0.0091 0.4641
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0082 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Echinococcus multilocularis Ras associated and pleckstrin y 0.0031 0.0077 0.0162
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0031 0.0077 0.0162
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0082 0.1005
Echinococcus granulosus axis inhibition protein axin 0.0194 0.0592 0.1302
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Echinococcus granulosus cGMP dependent protein kinase 0.001 0.0012 0.002
Leishmania major hypothetical protein, conserved 0.0031 0.0077 0.3777
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus granulosus cytohesin 1 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0097 0.0208
Echinococcus multilocularis serotonin receptor 0.0032 0.0082 0.0174
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0012 0.002
Echinococcus granulosus Protein Wnt-111 0.0013 0.0021 0.004
Echinococcus granulosus zinc finger transcription factor gli2 0.0301 0.0931 0.2052
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0082 0.0076
Toxoplasma gondii protein kinase domain-containing protein 0.0035 0.0091 0.5627
Brugia malayi putative neuropeptide receptor 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0116 0.0242
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0007 0.0092
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Echinococcus multilocularis regulator of G protein signaling 0.0194 0.0592 0.1302
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0651 0.2037 0.2032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0153 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0194 0.0592 0.1296
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0031 0.0077 0.3777
Brugia malayi TBC domain containing protein 0.0031 0.0077 0.007
Brugia malayi Cytohesin 3 0.0031 0.0077 0.007
Brugia malayi Serotonin receptor 0.0032 0.0082 0.0076
Schistosoma mansoni oxysterol-binding protein 1 0.0031 0.0077 0.0167
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0315 0.0309
Brugia malayi Muscleblind-like protein 0.0299 0.0924 0.0918
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Echinococcus granulosus oxysterol binding protein 3 0.0031 0.0077 0.0162
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0019 0.0035
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0019 0.0035
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0016
Echinococcus granulosus beta-adrenergic receptor kinase 0.1437 0.4524 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0016
Echinococcus granulosus Protein Wnt-11b 0.0013 0.0021 0.004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0052 0.5
Echinococcus granulosus Rho GTPase activating protein 24 0.0031 0.0077 0.0162
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0091 0.02
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0082 0.0174
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0031 0.0077 0.6314
Loa Loa (eye worm) hypothetical protein 0.0034 0.0086 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Onchocerca volvulus 0.0031 0.0077 0.0929
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0016
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0019 0.004
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0077 0.007
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Brugia malayi sulfakinin receptor protein 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0031 0.0077 0.0167
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni cpg binding protein 0.0028 0.0069 0.0151
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0183 0.0397
Brugia malayi Oxysterol-binding protein 0.0031 0.0077 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Toxoplasma gondii Oxysterol-binding protein 0.0031 0.0077 0.4579
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0082 0.0179
Echinococcus granulosus somatostatin receptor 0.0032 0.0082 0.0174
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0035 0.0091 1
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0077 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0154 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0082 0.0174
Schistosoma mansoni dynamin 0.0031 0.0077 0.0167
Schistosoma mansoni axis inhibition protein axin 0.0194 0.0592 0.1306
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) PXA domain-containing protein 0.0194 0.0592 0.1296
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0082 0.0174
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0082 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0052 0.0715
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Toxoplasma gondii exonuclease III APE 0.0023 0.0052 0.2784
Schistosoma mansoni opsin-like receptor 0.0032 0.0082 0.0179
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0082 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0082 0.0179
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0052 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0082 0.0179
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0082 0.0174
Echinococcus granulosus g protein coupled receptor 0.0032 0.0082 0.0174
Schistosoma mansoni goodpasture antigen-binding protein 0.0031 0.0077 0.0167
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0052 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0315 0.0683
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0082 0.0174
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0082 0.0174
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Echinococcus multilocularis actin binding protein anillin 0.0031 0.0077 0.0162
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis myotubularin protein 13 0.0031 0.0077 0.0162
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis oxysterol binding protein 1 0.0031 0.0077 0.0162
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0004
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0082 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0075 0.0163
Echinococcus granulosus DCC interacting protein 13 beta 0.0031 0.0077 0.0162
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0086 0.0182
Brugia malayi Dynamin 0.0031 0.0077 0.007
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0012 0.0025
Trichomonas vaginalis alpha chimerin, putative 0.0031 0.0077 0.1064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0016
Echinococcus multilocularis GRB2 associated binding protein 3 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0082 0.0174
Schistosoma mansoni ap endonuclease 0.0023 0.0052 0.0111
Schistosoma mansoni centaurin alpha 0.0031 0.0077 0.0167
Echinococcus granulosus serotonin receptor 0.0032 0.0082 0.0174
Leishmania major protein kinase, putative 0.0035 0.0091 0.4641
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.007
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0739
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0035 0.0091 0.1269
Trichomonas vaginalis centaurin gamma, putative 0.0031 0.0077 0.1064
Brugia malayi Wnt-2 protein precursor 0.0013 0.0021 0.0015
Onchocerca volvulus 0.0031 0.0077 0.0929
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0077 0.6314
Echinococcus multilocularis Pleckstrin y 0.0031 0.0077 0.0162
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0457 0.1425 0.3145
Loa Loa (eye worm) rho-GTPase-activating 0.0031 0.0077 0.0155
Brugia malayi neuropeptide F receptor 0.0032 0.0082 0.0076
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0082 0.0174
Trichomonas vaginalis kinesin light chain, putative 0.0031 0.0077 0.1064
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis sex peptide receptor 0.0032 0.0082 0.0174
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0035 0.0091 0.4808
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0086 0.0182
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.2103 0.4647
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0069 0.0139
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0007 0.0012
Echinococcus granulosus GRB2 associated binding protein 3 0.0031 0.0077 0.0162
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0031 0.0077 0.1064
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Schistosoma mansoni goodpasture antigen-binding protein 0.0031 0.0077 0.0167
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0035 0.0091 0.4641
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Echinococcus granulosus protein Wnt 1 0.0013 0.0021 0.004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0102 0.0219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0086 0.0175
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1243 0.3912 0.8645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0339
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0082 0.0174
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0011 0.0021
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis protein transport protein sec7, putative 0.0031 0.0077 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0004
Echinococcus multilocularis cytohesin 1 0.0031 0.0077 0.0162
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0019 0.0013
Entamoeba histolytica PH domain containing protein 0.0031 0.0077 0.0467
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0035 0.0091 0.1269
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0082 0.0167
Echinococcus granulosus regulator of G protein signaling 7 0.0194 0.0592 0.1302
Echinococcus multilocularis oxysterol binding protein 9 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Entamoeba histolytica hypothetical protein 0.0194 0.0592 1
Schistosoma mansoni myotubularin-related protein 0.0031 0.0077 0.0167
Brugia malayi Dopamine receptor 0.0032 0.0082 0.0076
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0031 0.0077 0.1064
Echinococcus granulosus G protein coupled receptor kinase 1 0.1243 0.3912 0.8645
Onchocerca volvulus 0.0032 0.0082 0.1005
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0151
Echinococcus multilocularis serotonin receptor 0.0032 0.0082 0.0174
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0031 0.0077 0.8138
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0077 0.8138
Loa Loa (eye worm) hypothetical protein 0.0299 0.0924 0.2031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0031 0.0077 0.1064
Echinococcus granulosus Oxysterol binding protein 11 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) syntrophin-1 0.0031 0.0077 0.0155
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0082 0.0174
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0082 0.0167
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0194 0.0592 0.1306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0004
Brugia malayi MAX-1A 0.0031 0.0077 0.007
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0086 0.0079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0082 0.1005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni rho gtpase activating protein 0.0031 0.0077 0.0167
Plasmodium falciparum PH domain-containing protein, putative 0.0031 0.0077 0.8138
Echinococcus multilocularis WNT 0.0013 0.0021 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0012 0.002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0183 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0035 0.0091 0.3044
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0082 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Brugia malayi Cadps2 protein 0.0031 0.0077 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Trypanosoma brucei rac serine-threonine kinase, putative 0.0035 0.0091 0.4808
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0183 0.0176
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0086 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0004
Schistosoma mansoni coup transcription factor 0.001 0.0011 0.0021
Plasmodium falciparum calcium-dependent protein kinase 7 0.0035 0.0091 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0005 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0004
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0082 0.0179
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0007 0.0012
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0082 0.0076
Brugia malayi Uncoordinated protein 104 0.0031 0.0077 0.007
Schistosoma mansoni hypothetical protein 0.0404 0.1256 0.2775
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Brugia malayi CXXC zinc finger family protein 0.0028 0.0069 0.0063
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0082 0.0174
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Trypanosoma brucei PH domain containing protein, putative 0.0031 0.0077 0.397
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0052 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0016
Brugia malayi hypothetical protein 0.0194 0.0592 0.0586
Schistosoma mansoni cpg binding protein 0.003 0.0074 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0077 0.0167
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni myosin xvIII 0.0032 0.0082 0.0179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0154 0.0327
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0082 0.0179
Trichomonas vaginalis centaurin alpha, putative 0.0031 0.0077 0.1064
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0082 0.0174
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0082 0.0174
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Leishmania major protein kinase, putative 0.0035 0.0091 0.4641
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0097 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.1437 0.4524 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0005 0.0004
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus multilocularis dynamin 1 0.0031 0.0077 0.0162
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0011 0.0017
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1437 0.4524 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus g protein coupled receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Brugia malayi Oxysterol binding protein 0.0031 0.0077 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0031 0.0077 0.1922
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0031 0.0077 0.0162
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0011 0.0021
Echinococcus multilocularis muscleblind protein 1 0.0299 0.0924 0.2036
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0082 0.0174
Echinococcus granulosus fmrfamide receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0011 0.0017
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0091 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.1256 0.2772
Entamoeba histolytica PH domain containing protein 0.0031 0.0077 0.0467
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.0004
Echinococcus multilocularis oxysterol binding protein 3 0.0031 0.0077 0.0162
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0116 0.0249
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0031 0.0077 0.0167
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0739
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0194 0.0592 0.1306
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0004
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0031 0.0077 0.0162
Echinococcus granulosus Protein Wnt-5 0.0013 0.0021 0.004
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0183 0.039
Echinococcus granulosus Regulator of G protein signaling 20 0.0194 0.0592 0.1302
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0209 0.0202
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Brugia malayi PXA domain containing protein 0.0194 0.0592 0.0586
Plasmodium vivax PH domain containing protein 0.0031 0.0077 0.6314
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0007 0.0007
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0128 0.0281
Loa Loa (eye worm) wnt-4 protein 0.0013 0.0021 0.0033
Echinococcus multilocularis somatostatin receptor 0.0032 0.0082 0.0174
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0019 0.0035
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0082 0.0076
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0031 0.0077 0.0162
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0052 0.5
Onchocerca volvulus 0.0032 0.0082 0.1005
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0082 0.0167
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Loa Loa (eye worm) Plekhf2 protein 0.0031 0.0077 0.0155
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0082 0.0174
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Onchocerca volvulus 0.0032 0.0082 0.1005
Onchocerca volvulus 0.0032 0.0082 0.1005
Trichomonas vaginalis hypothetical protein 0.0031 0.0077 0.1064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0116 0.0109
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0102 0.0224
Brugia malayi Pleckstrin Homology Domain 0.0031 0.0077 0.007
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0082 0.0174
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0457 0.1425 0.1419
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0721 1
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0082 0.0174
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0007 0.0007
Echinococcus multilocularis expressed conserved protein 0.001 0.0012 0.002
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0031 0.0077 0.0167
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0183 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0031 0.0077 0.0155
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0012
Trypanosoma brucei protein kinase, putative 0.0035 0.0091 0.4808
Brugia malayi A-kinase anchor protein 10, precursor 0.0194 0.0592 0.0586
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0082 0.0167
Echinococcus multilocularis Pleckstrin y 0.0031 0.0077 0.0162
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0082 0.0174
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0183 1
Plasmodium vivax SET domain protein, putative 0.003 0.0075 0.5832
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus multilocularis beta adrenergic receptor kinase 0.1437 0.4524 1
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0082 0.0174
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Onchocerca volvulus 0.0028 0.0069 0.0824
Echinococcus granulosus calcium dependent secretion activator 1 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0004
Onchocerca volvulus outspread protein homolog 0.0031 0.0077 0.0929
Brugia malayi Dopamine receptor protein 1 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi hypothetical protein 0.0031 0.0077 0.007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0011 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Onchocerca volvulus 0.0031 0.0077 0.0929
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0009
Trichomonas vaginalis centaurin beta, putative 0.0031 0.0077 0.1064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Brugia malayi Melatonin receptor type 1A 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0183 0.0397
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0082 0.0174
Schistosoma mansoni biogenic amine receptor 0.0032 0.0082 0.0179
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0035 0.0091 0.3044
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Brugia malayi Plekhf2 protein 0.0031 0.0077 0.007
Brugia malayi larval opioid receptor 0.0032 0.0082 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0082 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0651 0.2037 0.4502
Schistosoma mansoni cpg binding protein 0.003 0.0074 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0163
Brugia malayi PXA domain containing protein 0.0194 0.0592 0.0586
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0154 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0031 0.0077 0.8138
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0082 0.0179
Schistosoma mansoni biogenic amine receptor 0.0032 0.0082 0.0179
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0035 0.0091 0.4808
Brugia malayi Pre-SET motif family protein 0.003 0.0075 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0075 0.0158
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0082 0.0174
Entamoeba histolytica p21-activated kinase 0.0035 0.0091 0.0739
Onchocerca volvulus 0.003 0.0075 0.0902
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0082 0.0174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0154 0.0334
Echinococcus multilocularis wingless type MMTV integration site family 0.0013 0.0021 0.004
Brugia malayi Egg laying defective protein 4 0.001 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0082 0.0174
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0012
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0031 0.0077 0.0162
Echinococcus multilocularis beta 1 syntrophin 0.0031 0.0077 0.0162
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0005 0.0004
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0035 0.0091 0.3044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0082 0.0174
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0082 0.0174
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0021
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0082 0.0174
Echinococcus granulosus serine/threonine protein kinase 0.0035 0.0091 0.0195
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Brugia malayi G-protein coupled receptor 0.0032 0.0082 0.0076
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus multilocularis zinc finger transcription factor gli2 0.0301 0.0931 0.2052
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0339
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.007
Brugia malayi Regulator of G protein signaling domain containing protein 0.0194 0.0592 0.0586
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Brugia malayi G protein-coupled receptor 0.0032 0.0082 0.0076
Echinococcus granulosus neuropeptide receptor 0.0032 0.0082 0.0174
Echinococcus granulosus dnaJ subfamily B 0.0404 0.1256 0.2772
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis DCC interacting protein 13 beta 0.0031 0.0077 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.1437 0.4524 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0077 0.0467
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0009
Echinococcus granulosus pdz domain containing protein 0.0031 0.0077 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0009
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0035 0.0091 0.3044
Echinococcus granulosus dynamin 1 0.0031 0.0077 0.0162
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Loa Loa (eye worm) zinc finger protein 0.0301 0.0931 0.2047
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0457 0.1425 0.314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0052 0.4948
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0128 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0031 0.0077 0.0929
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0035 0.0091 0.3044
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0082 0.0179
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0052 0.0107
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0031 0.0077 0.0162
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Echinococcus granulosus oxysterol binding protein 9 0.0031 0.0077 0.0162
Echinococcus multilocularis regulator of G protein signaling 7 0.0194 0.0592 0.1302
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0012 0.0025
Echinococcus multilocularis WNT 0.0013 0.0021 0.004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0082 0.0167
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0082 0.0179
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Echinococcus multilocularis regulator of G protein signaling 7 0.0194 0.0592 0.1302
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0031 0.0077 0.007
Brugia malayi Dopamine receptor protein 2 0.0032 0.0082 0.0076
Loa Loa (eye worm) histone methyltransferase 0.001 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0194 0.0592 0.1306
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0016
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0031 0.0077 0.1064
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0082 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0004
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0107 0.1481
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.0004
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0035 0.0091 0.4641
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0016
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0082 0.0167
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Onchocerca volvulus 0.0234 0.0721 1
Brugia malayi steroid hormone receptor 0.001 0.0011 0.0004
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0031 0.0077 0.1064
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0082 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0012 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0082 0.0174
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Loa Loa (eye worm) hypothetical protein 0.0299 0.0924 0.2031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0116 0.0249
Brugia malayi probable spectrin beta chain 0.0031 0.0077 0.007
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Echinococcus granulosus neuropeptide receptor 0.0032 0.0082 0.0174
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0007 0.0007
Echinococcus granulosus sex peptide receptor 0.0032 0.0082 0.0174
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0016
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0082 0.0174
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0194 0.0592 0.1302
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Brugia malayi Regulator of G protein signaling domain containing protein 0.0194 0.0592 0.0586
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Echinococcus granulosus muscleblind protein 0.0299 0.0924 0.2036
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Onchocerca volvulus 0.0031 0.0077 0.0929
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0082 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0082 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0082 0.0174
Onchocerca volvulus 0.0032 0.0082 0.1005
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Entamoeba histolytica PH domain containing protein 0.0031 0.0077 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0154 0.0334
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0031 0.0077 0.6314
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0031 0.0077 0.1922
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0011 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0082 0.0167
Onchocerca volvulus 0.0031 0.0077 0.0929
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.2103 0.4644
Schistosoma mansoni zinc finger protein 0.0031 0.0077 0.0167
Onchocerca volvulus Putative zinc finger protein 0.0031 0.0077 0.0929
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0102 0.0219
Loa Loa (eye worm) hypothetical protein 0.0072 0.0209 0.0448
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0082 0.0076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0009
Echinococcus granulosus hypothetical protein 0.0032 0.0082 0.0174
Leishmania major serine/threonine-protein kinase a, putative 0.0035 0.0091 0.4641
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0194 0.0592 0.1302
Schistosoma mansoni ap endonuclease 0.0023 0.0052 0.0111
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0031 0.0077 0.0167
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Loa Loa (eye worm) uncoordinated protein 104 0.0031 0.0077 0.0155
Trichomonas vaginalis centaurin/arf, putative 0.0031 0.0077 0.1064
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0035 0.0091 0.4808
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0075 0.4442
Echinococcus granulosus GPCR family 2 0.0034 0.0086 0.0182
Brugia malayi Zinc finger, C2H2 type family protein 0.0301 0.0931 0.0925
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Brugia malayi neuropeptide F receptor 0.0032 0.0082 0.0076
Echinococcus multilocularis Rho GTPase activating protein 24 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis Oxysterol binding protein 11 0.0031 0.0077 0.0162
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0183 0.2429
Echinococcus granulosus g protein coupled receptor 0.0032 0.0082 0.0174
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0012
Schistosoma mansoni histamine h1 receptor 0.0032 0.0082 0.0179
Echinococcus granulosus Pleckstrin y 0.0031 0.0077 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0315 0.0309
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis Pleckstrin y 0.0031 0.0077 0.0162
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0031 0.0077 0.1922
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis wnt family member wnt11 2 0.0013 0.0021 0.004
Brugia malayi regulator of G-protein signaling egl-10 0.0194 0.0592 0.0586
Echinococcus multilocularis expressed protein 0.0194 0.0592 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni dynamin 0.0031 0.0077 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus Pleckstrin y 0.0031 0.0077 0.0162
Toxoplasma gondii hypothetical protein 0.0031 0.0077 0.4579
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0031 0.0077 0.0467
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0202
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0031 0.0077 0.0162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0086 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0052 0.0099
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0457 0.1425 0.3145
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0077 0.8138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0004
Brugia malayi Dynamin 0.0031 0.0077 0.007
Schistosoma mansoni adenoreceptor 0.0032 0.0082 0.0179
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Syntrophin-1 0.0031 0.0077 0.007
Entamoeba histolytica hypothetical protein 0.0194 0.0592 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0021
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0031 0.0077 0.0162
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0069 0.0146
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Trichomonas vaginalis centaurin/arf, putative 0.0031 0.0077 0.1064
Echinococcus granulosus regulator of G protein signaling 7 0.0194 0.0592 0.1302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0086 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0082 0.0174
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0052 0.0107
Loa Loa (eye worm) RGS-3 protein 0.0194 0.0592 0.1296
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0651 0.2037 0.4495
Trichomonas vaginalis protein transport protein sec7, putative 0.0031 0.0077 0.1064
Trypanosoma cruzi NIMA-related kinase, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis axis inhibition protein axin 0.0194 0.0592 0.1302
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0075 0.0158
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0194 0.0592 0.8211
Loa Loa (eye worm) oxysterol binding protein 0.0031 0.0077 0.0155
Brugia malayi Wnt-4 protein precursor 0.0013 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus granulosus expressed protein 0.0194 0.0592 0.1302
Loa Loa (eye worm) AGC/AKT protein kinase 0.0035 0.0091 0.0188
Loa Loa (eye worm) hypothetical protein 0.0106 0.0315 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis axis inhibition protein axin 0.0194 0.0592 0.1302
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0183 0.0402
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0631 0.1383
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0082 0.0174
Echinococcus granulosus microtubule associated protein 2 0.0671 0.2103 0.4644
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0082 0.0174
Onchocerca volvulus Protein melted homolog 0.0031 0.0077 0.0929
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0107 0.1481
Echinococcus granulosus regulator of G protein signaling 3 0.0194 0.0592 0.1302
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0457 0.1425 0.314
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0052 0.2297
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0011 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0007 0.0092
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0009
Trypanosoma cruzi Protein kinase B 0.0035 0.0091 0.3044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0011 0.0021
Schistosoma mansoni oxysterol-binding protein 1 0.0031 0.0077 0.0167
Loa Loa (eye worm) CWN-2 protein 0.0013 0.0021 0.0033
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0031 0.0077 0.0162
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0075 0.0158
Schistosoma mansoni hypothetical protein 0.0039 0.0102 0.0224
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0052 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Echinococcus multilocularis rac serine:threonine kinase 0.0035 0.0091 0.0195
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) Wnt2 protein 0.0013 0.0021 0.0033
Onchocerca volvulus 0.0031 0.0077 0.0929
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0007 0.0007
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0019 0.0035
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0031 0.0077 0.0162
Echinococcus multilocularis Regulator of G protein signaling 20 0.0194 0.0592 0.1302
Echinococcus multilocularis calcium dependent secretion activator 1 0.0031 0.0077 0.0162
Schistosoma mansoni z-protein (S1r protein) 0.0194 0.0592 0.1306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0004
Echinococcus granulosus Protein Wnt-04 0.0013 0.0021 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0077 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0009
Echinococcus granulosus myotubularin protein 13 0.0031 0.0077 0.0162
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0021
Echinococcus granulosus Pleckstrin y 0.0031 0.0077 0.0162
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0012 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0007 0.0007
Brugia malayi RE15519p 0.0032 0.0082 0.0076
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus granulosus regulator of G protein signaling 3 0.0194 0.0592 0.1302
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0031 0.0077 0.0929
Echinococcus multilocularis regulator of G protein signaling 3 0.0194 0.0592 0.1302
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0035 0.0091 0.3044
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0005 0.0004
Schistosoma mansoni syntrophin 0.0031 0.0077 0.0167
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0082 0.0174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0082 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0011 0.0021
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Echinococcus granulosus axis inhibition protein axin 0.0194 0.0592 0.1302
Loa Loa (eye worm) PH domain-containing protein 0.0031 0.0077 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis regulator of G protein signaling 3 0.0194 0.0592 0.1302
Echinococcus multilocularis cpg binding protein 0.003 0.0074 0.0157
Brugia malayi regulator of G-protein signaling rgs-7 0.0194 0.0592 0.0586
Entamoeba histolytica ARF GTPase activating protein, putative 0.0031 0.0077 0.0467
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0035 0.0091 0.5627
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Toxoplasma gondii hypothetical protein 0.0031 0.0077 0.4579
Toxoplasma gondii AtPH1 family protein 0.0031 0.0077 0.4579
Schistosoma mansoni axis inhibition protein axin 0.0194 0.0592 0.1306
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Onchocerca volvulus 0.0032 0.0082 0.1005
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0082 0.0167
Schistosoma mansoni hypothetical protein 0.0072 0.0209 0.0459
Onchocerca volvulus 0.0032 0.0082 0.1005
Brugia malayi Protein kinase domain containing protein 0.0035 0.0091 0.0085
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0052 0.2536
Schistosoma mansoni opsin-like receptor 0.0032 0.0082 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0339
Echinococcus multilocularis pleckstrin y domain containing family A 0.0031 0.0077 0.0162
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0011 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus multilocularis muscleblind protein 0.0299 0.0924 0.2036
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0082 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0154 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) cytohesin 3 0.0031 0.0077 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0035 0.0091 0.4808
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0004
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.0004
Echinococcus granulosus protein Wnt 2 0.0013 0.0021 0.004
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Brugia malayi hypothetical protein 0.0194 0.0592 0.0586
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0007 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Entamoeba histolytica hypothetical protein 0.0194 0.0592 1
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0019 0.004
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0031 0.0077 0.1064
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0082 0.0174
Echinococcus granulosus orexin receptor type 2 0.0032 0.0082 0.0174
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0032 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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