Detailed information for compound 1578138

Basic information

Technical information
  • TDR Targets ID: 1578138
  • Name: 5-(dithiolan-3-yl)-N-[6-[ethyl-[(2-methoxyphe nyl)methyl]amino]hexyl]pentanamide
  • MW: 452.717 | Formula: C24H40N2O2S2
  • H donors: 1 H acceptors: 1 LogP: 4.72 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(Cc1ccccc1OC)CCCCCCNC(=O)CCCCC1SSCC1
  • InChi: 1S/C24H40N2O2S2/c1-3-26(20-21-12-6-8-14-23(21)28-2)18-11-5-4-10-17-25-24(27)15-9-7-13-22-16-19-29-30-22/h6,8,12,14,22H,3-5,7,9-11,13,15-20H2,1-2H3,(H,25,27)
  • InChiKey: PAPNIDWABUXIRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(3-dithiolanyl)-N-[6-[ethyl-[(2-methoxyphenyl)methyl]amino]hexyl]pentanamide
  • 5-(dithiolan-3-yl)-N-[6-[ethyl-(2-methoxybenzyl)amino]hexyl]valeramide
  • 5-(1,2-dithiolan-3-yl)-N-[6-[ethyl-[(2-methoxyphenyl)methyl]amino]hexyl]pentanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0196 0.0198
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0048 0.0218 0.0994
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.4092 1
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0054 0.0261 0.0265
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.003 0.0776
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.003 0.0029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0313 0.0287
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0165 0.0332
Echinococcus granulosus caspase 2 0.0092 0.0517 0.0526
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0165 0.0801
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0035 0.013 0.0131
Schistosoma mansoni hypothetical protein 0.0044 0.0196 0.02
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0023 0.0051 0.0024
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0313 0.032
Echinococcus granulosus dna polymerase kappa 0.0044 0.0195 0.0197
Brugia malayi CXXC zinc finger family protein 0.0061 0.0309 0.1412
Schistosoma mansoni BC026374 protein (S09 family) 0.0028 0.0083 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0285 0.1303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0026 0.0027
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0036 0.0141 0.0685
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.2038 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1052 0.1071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0043 0.0043
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0282 0.0286
Schistosoma mansoni caspase-7 (C14 family) 0.0126 0.0746 0.0761
Schistosoma mansoni rab6-interacting 0.0021 0.004 0.0041
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0228 0.1111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0381 0.0387
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0232 0.0235
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0165 0.0332
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0274
Schistosoma mansoni succinate dehydrogenase 0.0023 0.0051 0.0052
Trypanosoma cruzi metacaspase, putative 0.0048 0.0218 0.1062
Echinococcus multilocularis microtubule associated protein 2 0.1466 0.9803 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0053 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.027 0.3686
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0036 0.0141 0.0142
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.01 0.0171
Trichomonas vaginalis spcc417.12 protein, putative 0.0028 0.0083 0.0132
Schistosoma mansoni polycystin 1-related 0.0021 0.004 0.0041
Loa Loa (eye worm) MBCTL1 0.0057 0.0282 0.1287
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0195 0.0197
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.008 0.0439 0.2011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0043 0.0044
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0049 0.023 0.0233
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0048 0.0218 0.0222
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Echinococcus granulosus acetylcholinesterase 0.0164 0.1003 0.1021
Echinococcus multilocularis caspase 2 0.0092 0.0517 0.0526
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0153 0.0743
Mycobacterium tuberculosis Probable reductase 0.01 0.0572 0.059
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0361 0.1651
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0338 0.0348
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.027 0.1318
Trypanosoma cruzi succinate dehydrogenase, putative 0.0035 0.013 0.0631
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.027 0.0275
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.001 0.0009
Onchocerca volvulus 0.0099 0.0565 1
Echinococcus multilocularis zinc finger protein 0.003 0.0097 0.0097
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0313 0.0287
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0049 0.023 0.1121
Mycobacterium tuberculosis Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogena 0.0023 0.0051 0.0051
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0338 0.4609
Loa Loa (eye worm) CBP-B 0.0082 0.045 0.206
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0954 0.4378
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0232 0.0235
Onchocerca volvulus 0.0028 0.0083 0.0832
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.3176 0.3238
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0313 0.0322
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0016
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.027 0.0274
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0404
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0721 0.0674
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0083 0.0085
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Brugia malayi jmjC domain containing protein 0.0017 0.001 0.004
Schistosoma mansoni zinc finger protein 0.003 0.0097 0.0099
Mycobacterium tuberculosis Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) 0.0023 0.0051 0.0051
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0153 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0043 0.0192
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0282 0.0287
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0721 0.0744
Echinococcus granulosus microtubule associated protein 2 0.1466 0.9803 1
Brugia malayi ecdysteroid receptor 0.0022 0.0043 0.0192
Loa Loa (eye worm) inositol-1 0.004 0.0165 0.075
Treponema pallidum fructose-bisphosphate aldolase 0.0621 0.4092 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0298 0.0302
Giardia lamblia Fructose-bisphosphate aldolase 0.0621 0.4092 1
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0595 0.0605
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0361 0.0368
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0036 0.0141 0.0144
Brugia malayi jmjC domain containing protein 0.0017 0.001 0.004
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.001 0.0043
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0118 0.0217
Schistosoma mansoni cpg binding protein 0.0061 0.0309 0.0315
Brugia malayi hypothetical protein 0.0021 0.004 0.0175
Brugia malayi CHE-14 protein 0.0044 0.0196 0.0894
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0228 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0595 0.1453
Echinococcus multilocularis protein dispatched 1 0.0051 0.0238 0.0242
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0043 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0198 0.0962
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0313 0.0318
Leishmania major NADH dehydrogenase, putative 0.0035 0.0134 0.0649
Brugia malayi hypothetical protein 0.0029 0.009 0.0404
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.0572 0.059
Giardia lamblia DINP protein human, muc B family 0.0023 0.005 0.0048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.003 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0043 0.0044
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0196 0.0198
Plasmodium vivax glutathione reductase, putative 0.0049 0.0228 0.8683
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0118 0.0571
Plasmodium falciparum glutathione reductase 0.0049 0.0228 0.8683
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.005 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.003 0.0139
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0228 0.8703
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0043 0.0192
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0053 0.1685
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) 0.0023 0.0051 0.005
Echinococcus granulosus zinc finger protein 0.003 0.0097 0.0097
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0053 0.025
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0767
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0313 0.153
Echinococcus multilocularis acetylcholinesterase 0.0164 0.1003 0.1021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Echinococcus granulosus BC026374 protein S09 family 0.0028 0.0083 0.0083
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0298 0.0302
Schistosoma mansoni lipoxygenase 0.0059 0.0298 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0043 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0324 0.0329
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0043 0.0044
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0196 0.0198
Echinococcus multilocularis acetylcholinesterase 0.0164 0.1003 0.1021
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0165 0.0403
Brugia malayi Cell death protein 3 precursor 0.0092 0.0517 0.237
Schistosoma mansoni phd/f-box containing protein 0.0017 0.001 0.0011
Echinococcus multilocularis succinate dehydrogenase iron sulfur protein 0.003 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.0463
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit, putative 0.0035 0.013 0.0631
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.003 0.0776
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Schistosoma mansoni lipoxygenase 0.0021 0.004 0.0041
Leishmania major eukaryotic translation initiation factor-like 0.0036 0.0141 0.0685
Brugia malayi steroid hormone receptor 0.0022 0.0043 0.0192
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.003 0.0073
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.027 0.0274
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.001 0.0043
Brugia malayi Carboxylesterase family protein 0.0164 0.1003 0.4602
Loa Loa (eye worm) succinate-ubiquinone oxidoreductase 0.0023 0.0051 0.0226
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0053 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0043 0.0192
Mycobacterium tuberculosis Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) 0.003 0.0098 0.01
Trypanosoma brucei Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0023 0.0051 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0044 0.0196 0.0892
Mycobacterium tuberculosis Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate deh 0.003 0.0098 0.01
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.008 0.0439 0.2011
Echinococcus multilocularis neuroligin 0.0028 0.0083 0.0083
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0035 0.0134 0.4924
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Schistosoma mansoni bromodomain containing protein 0.0076 0.0407 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1052 0.1071
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.003 0.0139
Brugia malayi hypothetical protein 0.0021 0.004 0.0175
Echinococcus granulosus RUN 0.0021 0.004 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0053 0.025
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0049 0.023 0.0233
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0401
Loa Loa (eye worm) hypothetical protein 0.0033 0.0122 0.0555
Onchocerca volvulus 0.0061 0.0309 0.5125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0282 0.1287
Schistosoma mansoni jumonji domain containing protein 0.0017 0.001 0.0011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0043 0.0069
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.2726
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1052 0.4828
Echinococcus granulosus hypothetical protein 0.0029 0.0089 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0043 0.0192
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0043 0.0043
Brugia malayi hypothetical protein 0.0028 0.0083 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0017 0.0075
Brugia malayi mbt repeat family protein 0.005 0.0235 0.1072
Schistosoma mansoni hypothetical protein 0.0021 0.004 0.0041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0053 0.025
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.027 0.0591
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0303 0.1946 0.1924
Schistosoma mansoni zinc finger protein 0.0016 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0029 0.0089 0.0091
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1495 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0165 0.0801
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0196 0.0198
Echinococcus granulosus protein quaking 0.0029 0.0089 0.009
Onchocerca volvulus 0.0053 0.0256 0.4115
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0338 0.0311
Mycobacterium ulcerans succinate dehydrogenase iron-sulfur subunit 0.003 0.0098 0.0071
Schistosoma mansoni hypothetical protein 0.0022 0.0043 0.0044
Schistosoma mansoni hypothetical protein 0.0308 0.198 0.202
Brugia malayi Carboxylesterase family protein 0.0164 0.1003 0.4602
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0053 0.0025
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.027 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0043 0.0192
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0134 0.0649
Brugia malayi jmjC domain containing protein 0.0017 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0054 0.0261 0.119
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.027 0.1318
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0338 0.0343
Schistosoma mansoni DNA polymerase eta 0.0016 0.0002 0.0002
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0153 0.0154
Schistosoma mansoni coup transcription factor 0.0022 0.0043 0.0044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0165 0.0138
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0083 0.0085
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.004 0.1169
Brugia malayi Carboxylesterase family protein 0.0028 0.0083 0.0376
Schistosoma mansoni neuroligin 3 (S09 family) 0.0028 0.0083 0.0085
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.008 0.0439 0.2148
Trypanosoma brucei metacaspase 0.0048 0.0218 0.1062
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0054 0.0261 0.0266
Toxoplasma gondii succinate dehydrogenase [ubiquinone] iron-sulfur protein 0.0054 0.0261 0.3563
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.001 0.0011
Trypanosoma cruzi metacaspase, putative 0.0048 0.0218 0.1062
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0324 0.033
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.004
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0053 0.0056
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.064 0.0592
Brugia malayi succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial 0.0054 0.0261 0.1192
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0141 0.0685
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.1003 0.4602
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0153 0.0695
Trypanosoma brucei ISWI complex protein 0.0016 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0398 0.1822
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0002 0.0002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0017 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0198 0.0962
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.001 0.0143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.064 0.066
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.01 0.045
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0303 0.1946 0.1905
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0228 0.104
Schistosoma mansoni gliotactin 0.0028 0.0083 0.0085
Mycobacterium leprae Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHY 0.003 0.0098 0.0048
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0195 0.0406
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0153 0.2087
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0043 0.0192
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0282 0.0286
Toxoplasma gondii exonuclease III APE 0.002 0.003 0.0408
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0025
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0721 0.0744
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0151 0.0153
Schistosoma mansoni inositol monophosphatase 0.004 0.0165 0.0168
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0049 0.023 0.3139
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0303 0.1946 0.2012
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0036 0.0141 0.0685
Toxoplasma gondii flavoprotein subunit of succinate dehydrogenase 0.0023 0.0051 0.0693
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0036 0.0141 0.1926
Schistosoma mansoni caspase-3 (C14 family) 0.0126 0.0746 0.0761
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.027 0.1318
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0043 0.0192
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0282 0.0286
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0274
Trypanosoma brucei protein kinase, putative 0.0055 0.027 0.1318
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0023 0.0051 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.027 0.0591
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0043 0.0189
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.01 0.01
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0324 0.0329
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.008 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0023 0.0051 0.021
Toxoplasma gondii hypothetical protein 0.0051 0.0242 0.3303
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.1256 0.128
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0188 0.0858
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0017 0.0016
Brugia malayi Carboxylesterase family protein 0.0028 0.0083 0.0376
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0049 0.023 0.1121
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0043 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.001 0.0143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.023 0.0236
Brugia malayi Thioredoxin reductase 0.0049 0.0228 0.104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0338 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0043 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0195 0.0948
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0083 0.0085
Plasmodium falciparum metacaspase-like protein 0.0048 0.0218 0.828
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0235 0.024
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0196 0.0409
Schistosoma mansoni hypothetical protein 0.0029 0.0089 0.0091
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.004 0.0039
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0235 0.024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0137 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0153 0.0303
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0002 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0035 0.0134 0.1827
Trypanosoma brucei trypanothione reductase 0.0049 0.0228 0.1111
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0085 0.0087
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0896 0.0912
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase flavoprotein subunit 0.0023 0.0051 0.0904
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0165 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.027 0.0591
Loa Loa (eye worm) glutathione reductase 0.0049 0.0228 0.104
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0053 0.1685
Brugia malayi Bromodomain containing protein 0.0088 0.049 0.2245
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0141 0.0685
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0118 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Echinococcus multilocularis CREB binding protein 0.0081 0.0443 0.0451
Echinococcus multilocularis BC026374 protein (S09 family) 0.0028 0.0083 0.0083
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0196 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.005 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0017 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0043 0.0044
Loa Loa (eye worm) carboxylesterase 0.0164 0.1003 0.4602
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.1256 0.128
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.0463
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.091 0.4461
Trypanosoma brucei Metacaspase-4 0.0048 0.0218 0.1062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0361 0.0368
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0028 0.0083 0.0132
Brugia malayi Doublecortin family protein 0.0021 0.004 0.0175
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.2038 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0198 0.0962
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0115 0.0675 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0043 0.0192
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.027 0.1318
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.0016
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0228 0.8683
Brugia malayi Temporarily assigned gene name protein 44 0.0029 0.009 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0043 0.0192
Echinococcus multilocularis protein quaking 0.0029 0.0089 0.009
Schistosoma mansoni inositol monophosphatase 0.004 0.0165 0.0168
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.0894 0.0911
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0043 0.0192
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0048 0.0047
Brugia malayi jmjC domain containing protein 0.0017 0.001 0.004
Schistosoma mansoni alpha glucosidase 0.0038 0.0153 0.0156
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0052
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0954 0.0972
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0036 0.0141 0.0142
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0235 0.1072
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0126 0.0746 0.076
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.091 0.4461
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0043 0.0044
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0174 0.0424
Onchocerca volvulus 0.0022 0.0043 0.0069
Echinococcus multilocularis CREB binding protein 0.0018 0.0017 0.0016
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0235 0.0238
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0188 0.039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0043 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0114
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0134 0.0649
Schistosoma mansoni cpg binding protein 0.0066 0.0346 0.0353
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.01 0.01
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0195 0.0406
Leishmania major eukaryotic translation initiation factor-like protein 0.0036 0.0141 0.0685
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0175
Leishmania major hypothetical protein, conserved 0.003 0.0098 0.0473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0043 0.0192
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.01 0.1359
Brugia malayi jmjC domain containing protein 0.0063 0.0324 0.1481
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0017 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0338 0.0311
Schistosoma mansoni protein phosphatase 2C 0.0017 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0053 0.0234
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0153 0.0374
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0043 0.0044
Trypanosoma brucei NADH dehydrogenase 0.0035 0.0134 0.0649
Schistosoma mansoni hypothetical protein 0.0043 0.0185 0.0189
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0023 0.0051 0.0051
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0053 0.025
Schistosoma mansoni acetylcholinesterase 0.0028 0.0083 0.0085
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0053 0.025
Trypanosoma cruzi Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0023 0.0051 0.0241
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.027 0.1234
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0053 0.0986
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0595 0.2726
Treponema pallidum NADH oxidase 0.0023 0.0053 0.0056
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0023 0.0051 0.0226
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.4092 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0153 0.0374
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1025 0.1058
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.01 0.01
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.3176 0.3238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0043 0.0192
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.003 0.0139
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0043 0.0192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0338 0.165
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0017 0.0018
Plasmodium falciparum thioredoxin reductase 0.0023 0.0053 0.1685
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0188 0.039
Onchocerca volvulus 0.0028 0.0083 0.0832
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Schistosoma mansoni alpha-glucosidase 0.0147 0.0891 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0043 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0043 0.0192
Echinococcus granulosus caspase 0.0126 0.0746 0.076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0282 0.1287
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0165 0.0801
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0153 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0043 0.0044
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.01 0.01
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.001 0.0009
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0083 0.0085
Loa Loa (eye worm) hypothetical protein 0.0054 0.0264 0.1204
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0053 0.025
Brugia malayi Bromodomain containing protein 0.0046 0.0206 0.094
Trichomonas vaginalis STE family protein kinase 0.008 0.0439 0.1007
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.091 0.4461
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0218 0.2974
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0023 0.0051 0.0226
Trypanosoma brucei metacaspase MCA3 0.0048 0.0218 0.1062
Echinococcus granulosus phd:f box containing protein 0.0017 0.001 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0147 0.0713
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0028 0.0083 0.0083
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0049 0.023 0.1121
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0309 0.1412
Echinococcus granulosus CREB binding protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) tumor suppressor 0.0337 0.2177 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.027 0.1318
Brugia malayi Carboxylesterase family protein 0.0028 0.0083 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0122 0.0592
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0195 0.0168
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0053 0.0401
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0195 0.0168
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0165 0.0332
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0228 0.0489
Echinococcus granulosus CREB binding protein 0.0018 0.0017 0.0016
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.008 0.0439 0.2148
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.027 0.0274
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.027 0.0591
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.004
Plasmodium vivax iron-sulfur subunit of succinate dehydrogenase, putative 0.0054 0.0261 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0028 0.0083 0.0056
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0049 0.023 0.0562
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0151 0.0153
Echinococcus multilocularis phd:f box containing protein 0.0017 0.001 0.0009
Schistosoma mansoni caspase-7 (C14 family) 0.0092 0.0517 0.0528
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0049 0.023 0.0492
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.003 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0338 0.0344
Echinococcus granulosus CREB binding protein 0.0115 0.0675 0.0687
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.007 0.2396
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0313 0.1432
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.064 0.066
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0153 0.0743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.004 0.0039
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.006 0.0268
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.008 0.0082
Trypanosoma brucei metacaspase MCA2 0.0048 0.0218 0.1062
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0043 0.0069
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.005 0.005
Schistosoma mansoni ap endonuclease 0.002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0376
Schistosoma mansoni hypothetical protein 0.0869 0.5768 0.5884
Echinococcus multilocularis cpg binding protein 0.0066 0.0346 0.0351
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0043 0.0044
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0049 0.023 0.0492
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.001 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.1003 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0043 0.0192
Schistosoma mansoni DNA helicase recq5 0.003 0.01 0.0102
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0043 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Brugia malayi nuclear hormone receptor 0.0022 0.0043 0.0192
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0043 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.0463
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0043 0.0069
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.001 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.001 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0195 0.0948
Trypanosoma cruzi metacaspase 5, putative 0.0048 0.0218 0.1062
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.0463
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0165 0.0166
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.0572 0.059
Onchocerca volvulus 0.0028 0.0083 0.0832
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.003 0.013
Loa Loa (eye worm) hypothetical protein 0.0164 0.1003 0.4602
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.004 0.0039
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0165 0.584
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0049 0.023 0.1049
Plasmodium falciparum thioredoxin reductase 0.0049 0.0228 0.8683
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.01 0.045
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.001 0.0009
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0049 0.023 0.0562
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0049 0.023 0.8761
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0235 0.024
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.027 0.0591
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0043 0.0044
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0118 0.0571
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0228 0.3119
Brugia malayi tumor suppressor. 0.0337 0.2177 1
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0049 0.023 0.018
Toxoplasma gondii thioredoxin reductase 0.0049 0.0228 0.3112
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0313 0.0318
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.064 0.066
Loa Loa (eye worm) hypothetical protein 0.0092 0.0517 0.237
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0153 0.0303
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0218 0.2974
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0153 0.0303
Schistosoma mansoni patched 1 0.0044 0.0196 0.02
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0053 0.0053
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0256 0.0261
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0174 0.6512
Echinococcus granulosus caspase 8 0.0048 0.0218 0.0221
Echinococcus granulosus CREB binding protein 0.0073 0.0393 0.0399
Schistosoma mansoni hypothetical protein 0.0043 0.0185 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0028 0.0083 0.0083
Schistosoma mansoni loxhd1 0.0021 0.004 0.0041
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.004 0.1169
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1052 0.4828
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.001 0.0009
Onchocerca volvulus Cell death protein 3 homolog 0.0092 0.0517 0.9093
Loa Loa (eye worm) carboxylesterase 0.0028 0.0083 0.0376
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Leishmania major metacaspase, putative 0.0048 0.0218 0.1062
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0771 0.0787
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0198 0.0962
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0043 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0228 0.0231
Echinococcus granulosus para nitrobenzyl esterase 0.0028 0.0083 0.0083
Echinococcus multilocularis caspase 3 0.0078 0.0425 0.0432
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0175
Onchocerca volvulus 0.005 0.0235 0.3715
Schistosoma mansoni hypothetical protein 0.0043 0.0185 0.0189
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0026 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0043 0.0043
Plasmodium falciparum flavoprotein subunit of succinate dehydrogenase 0.0023 0.0051 0.1609
Brugia malayi glutathione reductase 0.0049 0.0228 0.104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0043 0.0192
Schistosoma mansoni ap endonuclease 0.002 0.003 0.003
Echinococcus granulosus carboxylesterase 5A 0.0164 0.1003 0.1021
Leishmania major DNA polymerase kappa, putative 0.0023 0.005 0.0235
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0035 0.0134 0.1827
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0345
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0036 0.0158
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.2038 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0153 0.0303
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0218 0.2974
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0338 0.0343
Loa Loa (eye worm) acetyltransferase 0.0157 0.0954 0.4378
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Trypanosoma brucei metacaspase 5, putative 0.0048 0.0218 0.1062
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0053 0.0056
Echinococcus multilocularis dnaJ subfamily B 0.0869 0.5768 0.5884
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0053 0.025
Brugia malayi PHD-finger family protein 0.0035 0.0135 0.0612
Echinococcus granulosus expressed conserved protein 0.0097 0.0552 0.0562
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0235 0.3715
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0043 0.0192
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.0894 0.0911
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0049 0.023 0.0236
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0024 0.0103
Schistosoma mansoni microtubule-associated protein tau 0.1466 0.9803 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.0994
Onchocerca volvulus 0.0028 0.0083 0.0832
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.017 0.6369
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1052 0.1071
Schistosoma mansoni hypothetical protein 0.0043 0.0185 0.0189
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.004 0.0039
Leishmania major succinate dehydrogenase, putative 0.0035 0.013 0.0631
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0043 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0196 0.0198
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.102
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0174 0.0354
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0109
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0043 0.0043
Echinococcus granulosus neuropeptide s receptor 0.0485 0.3176 0.3238
Schistosoma mansoni protein kinase 0.008 0.0439 0.0448
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0324 0.0329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0083 0.0085
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.003 0.0139
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0067 0.0908
Brugia malayi polk-prov protein 0.0033 0.0122 0.0555
Schistosoma mansoni DNA helicase recq1 0.003 0.01 0.0102
Brugia malayi nuclear receptor NHR-88 0.0022 0.0043 0.0192
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0053 0.025
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0023 0.0051 0.021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0026 0.0025
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0188 0.0191
Loa Loa (eye worm) translation initiation factor 4E 0.0036 0.0141 0.0641
Mycobacterium tuberculosis Carboxylesterase LipT 0.0028 0.0083 0.0085
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0035 0.0134 0.0107
Echinococcus multilocularis CREB binding protein 0.0018 0.0017 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0732 1
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.008 0.0439 0.2148
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0218 0.828
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0595 0.0605
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Trichomonas vaginalis STE family protein kinase 0.008 0.0439 0.1007
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0153 0.0303
Echinococcus multilocularis CREB binding protein 0.0018 0.0017 0.0016
Echinococcus multilocularis caspase 0.0126 0.0746 0.076
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0228 0.3119
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0049 0.023 0.0235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.01 0.1359
Trypanosoma brucei unspecified product 0.0037 0.0147 0.0713
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.004 0.0039
Leishmania major trypanothione reductase 0.0049 0.0228 0.1111
Brugia malayi MAP kinase sur-1 0.0055 0.027 0.1234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Echinococcus multilocularis expressed conserved protein 0.0097 0.0552 0.0562
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0235 0.0238
Giardia lamblia Kinase, STE STE20 0.008 0.0439 0.1007
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0153 0.0303
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.01 0.045
Trypanosoma cruzi metacaspase 5, putative 0.0048 0.0218 0.1062
Loa Loa (eye worm) hypothetical protein 0.0044 0.0196 0.0894
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0053 0.025
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase iron-sulfur subunit 0.0054 0.0261 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0165 0.0801
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0235 0.0238
Leishmania major hypothetical protein, conserved 0.0017 0.001 0.0043
Echinococcus granulosus tumor protein p63 0.0363 0.2351 0.2397
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.3176 0.3238
Trypanosoma cruzi metacaspase, putative 0.0048 0.0218 0.1062
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0228 0.0489
Onchocerca volvulus 0.0028 0.0083 0.0832
Schistosoma mansoni alpha-glucosidase 0.0147 0.0891 0.0909
Brugia malayi Inositol-1 0.004 0.0165 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0043 0.0192
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.01 0.3556
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0053 0.1685
Brugia malayi Carboxylesterase family protein 0.0028 0.0083 0.0376
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.027 0.1318
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0165 0.225
Brugia malayi hypothetical protein 0.0044 0.0196 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.0463
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0345
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0053 0.0719
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.027 0.1318
Echinococcus granulosus bloom syndrome protein 0.0043 0.0188 0.0191
Schistosoma mansoni rab6-interacting 0.0021 0.004 0.0041
Plasmodium vivax flavoprotein subunit of succinate dehydrogenase, putative 0.0023 0.0051 0.1609
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit 0.003 0.0098 0.0473
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0053 0.0986
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0153 0.0303
Echinococcus multilocularis caspase 8 0.0048 0.0218 0.0221
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.003 0.0098 0.01
Schistosoma mansoni cpg binding protein 0.0066 0.0346 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0043 0.0192
Brugia malayi jmjC domain containing protein 0.0069 0.0361 0.1651
Echinococcus multilocularis RUN 0.0021 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.1072
Plasmodium falciparum metacaspase 1 0.0048 0.0218 0.828
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0035 0.0134 0.4924
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.0572 0.059
Chlamydia trachomatis succinate dehydrogenase iron sulfur subunit 0.003 0.0098 1
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.001 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0017 0.0075
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0118 0.0571
Trypanosoma cruzi metacaspase, putative 0.0048 0.0218 0.1062
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0049 0.023 0.0203
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0043 0.0043
Echinococcus multilocularis para nitrobenzyl esterase 0.0028 0.0083 0.0083
Schistosoma mansoni CREB-binding protein 2 0.0115 0.0675 0.0688
Loa Loa (eye worm) hypothetical protein 0.0051 0.0242 0.1106
Plasmodium vivax metacaspase 1, putative 0.0048 0.0218 0.828
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0023
Echinococcus granulosus succinate dehydrogenase (ubiquinone) iron sulfur 0.0054 0.0261 0.0265
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0043 0.0043
Loa Loa (eye worm) succinate dehydrogenase iron-sulfur protein 0.0054 0.0261 0.1192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0126 0.0746 0.076
Echinococcus granulosus neuroligin 0.0028 0.0083 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0264 0.1286
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0381 0.0387
Echinococcus granulosus dual specificity mitogen activated protein 0.008 0.0439 0.0446
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0002 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0048 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0153 0.0303
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0192
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0049 0.023 0.1121
Echinococcus granulosus cpg binding protein 0.0066 0.0346 0.0351
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.001 0.004
Trypanosoma brucei glucosidase, putative 0.0038 0.0153 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.0463
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0054
Trichomonas vaginalis STE family protein kinase 0.008 0.0439 0.1007
Echinococcus multilocularis dual specificity mitogen activated protein 0.008 0.0439 0.0446
Echinococcus granulosus caspase 3 0.0078 0.0425 0.0432
Brugia malayi mbt repeat family protein 0.005 0.0235 0.1072
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0043 0.0043
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.0016
Echinococcus multilocularis protein patched 0.0044 0.0196 0.0198
Echinococcus granulosus succinate dehydrogenase ubiquinone 0.0023 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0256 0.1168
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.2038 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0605 0.0618
Echinococcus multilocularis tumor protein p63 0.0363 0.2351 0.2397
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.001 0.0043
Brugia malayi translation initiation factor 4E 0.0036 0.0141 0.0641
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0361 0.0366
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0137 0.0086
Loa Loa (eye worm) carboxylesterase 0.0028 0.0083 0.0376
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.003 0.013
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0235 0.0238
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0053 0.1685
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0153 0.0695
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.004 0.0039
Plasmodium falciparum glutathione reductase 0.0023 0.0053 0.1685
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.008 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.4092 1
Echinococcus granulosus dnaJ subfamily B 0.0869 0.5768 0.5884
Loa Loa (eye worm) doublecortin family protein 0.0021 0.004 0.0175
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1446 0.9667 1
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0049 0.023 0.1049
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0282 0.0286
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0218 0.0463
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.001 0.004
Plasmodium falciparum iron-sulfur subunit of succinate dehydrogenase 0.0054 0.0261 1
Loa Loa (eye worm) RecQ helicase 0.0043 0.0188 0.0858
Leishmania major succinate dehydrogenase flavoprotein, putative 0.0023 0.0051 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Mycobacterium ulcerans hypothetical protein 0.0167 0.1025 0.1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.1003 0.1023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0053 0.0719
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0054 0.0261 0.0265
Echinococcus granulosus acetylcholinesterase 0.0164 0.1003 0.1021
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.003 0.0098 0.0473
Loa Loa (eye worm) hypothetical protein 0.0164 0.1003 0.4602
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0954 0.0973
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0049 0.023 0.8761
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0035 0.013 0.0631
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0043 0.0043
Brugia malayi TAZ zinc finger family protein 0.0115 0.0675 0.3094
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0024 0.0059 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0195 0.0948
Onchocerca volvulus 0.0044 0.0196 0.2972
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0153 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0043 0.0192
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0043 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0338 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0122 0.0592

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 37.6 % Antioxidant activity in human SH-SY5Y cells assessed as inhibition of tert-butyl hydroperoxide-induced intracellular ROS production at 50 uM after 24 hrs using DCFH-DA by fluorescence assay (Rvb = 82.4 +/- 6.6 %) ChEMBL. 21924801
Activity (functional) = 69.6 % Antioxidant activity in human SH-SY5Y cells assessed as inhibition of tert-butyl hydroperoxide-induced intracellular ROS production at 10 uM after 24 hrs using DCFH-DA by fluorescence assay (Rvb = 82.4 +/- 6.6 %) ChEMBL. 21924801
Activity (functional) = 75.8 % Antioxidant activity in human SH-SY5Y cells assessed as inhibition of tert-butyl hydroperoxide-induced intracellular ROS production at 5 uM after 24 hrs using DCFH-DA by fluorescence assay (Rvb = 82.4 +/- 6.6 %) ChEMBL. 21924801
Activity (functional) = 80.8 % Antioxidant activity in human SH-SY5Y cells assessed as inhibition of tert-butyl hydroperoxide-induced intracellular ROS production at 1 uM after 24 hrs using DCFH-DA by fluorescence assay (Rvb = 82.4 +/- 6.6 %) ChEMBL. 21924801
IC50 (binding) = 2.49 10'-6M Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay ChEMBL. 21924801
IC50 (binding) = 2.56 10'-7M Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay ChEMBL. 21924801
Inhibition (binding) = 16.8 % Inhibition of human AChE-induced amyloid beta (1 to 40) aggregation at 100 uM after 24 hrs by thioflavin T based fluorometric assay ChEMBL. 21924801

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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