Detailed information for compound 1578721

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.31 | Formula: C16H14F3N5O
  • H donors: 2 H acceptors: 2 LogP: 2.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2c(n1)c1cc(ccc1o2)C(F)(F)F
  • InChi: 1S/C16H14F3N5O/c17-16(18,19)7-1-2-11-10(3-7)12-13(25-11)14(23-15(20)22-12)24-6-8-4-9(24)5-21-8/h1-3,8-9,21H,4-6H2,(H2,20,22,23)/t8-,9-/m0/s1
  • InChiKey: SAGDGNYSLXHVGQ-IUCAKERBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jun-related protein 0.0076 0.0206 0.0192
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2554 0.9705 0.9705
Plasmodium falciparum glutathione reductase 0.0053 0.0116 0.0133
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0807 0.1051
Brugia malayi Thioredoxin reductase 0.0053 0.0116 0.0151
Echinococcus granulosus CREB binding protein 0.0121 0.0377 0.0364
Echinococcus multilocularis histone deacetylase 0.0325 0.116 0.1147
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0025 0.0033
Brugia malayi hypothetical protein 0.0077 0.0211 0.0274
Echinococcus granulosus histone deacetylase 8 0.0205 0.0701 0.0688
Brugia malayi Tubulin alpha-2 chain 0.1502 0.5672 0.7385
Toxoplasma gondii histone deacetylase HDAC1 0.0325 0.116 0.1494
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0379 0.0476
Echinococcus multilocularis histone deacetylase 3 0.0592 0.2182 0.2171
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0379 0.0476
Loa Loa (eye worm) hypothetical protein 0.0056 0.013 0.017
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0088
Trypanosoma brucei PAB1-binding protein , putative 0.0207 0.0707 0.0904
Brugia malayi paired box pox-meso protein 0.0028 0.0021 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0379 0.0476
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0039 0.0033
Loa Loa (eye worm) tubulin gamma chain 0.1148 0.4314 0.5617
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0212 0.0258
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0033 0.0044
Onchocerca volvulus 0.0034 0.0045 0.0081
Brugia malayi hypothetical protein 0.0134 0.0426 0.0555
Leishmania major hypothetical protein, conserved 0.004 0.0068 0.007
Brugia malayi BRCA1-associated protein 2 containing protein 0.0026 0.0014 0.0018
Echinococcus multilocularis Tubulin beta 2C chain 0.2026 0.768 0.7677
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.064 0.0626
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0174 0.0582 0.0569
Schistosoma mansoni nuclear hormone receptor 0.0064 0.016 0.0146
Echinococcus multilocularis tubulin alpha 0.1148 0.4314 0.4306
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0229 0.0793 0.078
Onchocerca volvulus TPPP family protein homolog 0.0409 0.148 0.2684
Loa Loa (eye worm) MH2 domain-containing protein 0.0046 0.0089 0.0116
Plasmodium vivax tubulin alpha chain, putative 0.1502 0.5672 0.738
Echinococcus granulosus histone deacetylase 6 0.0325 0.116 0.1147
Schistosoma mansoni hypothetical protein 0.0072 0.0189 0.0176
Echinococcus granulosus tubulin subunit beta 0.2026 0.768 0.7677
Trichomonas vaginalis tubulin beta chain, putative 0.1502 0.5672 0.738
Loa Loa (eye worm) p25-alpha family protein 0.0409 0.148 0.1927
Brugia malayi bHLH-PAS transcription factor 0.004 0.0068 0.0088
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.012 0.0374 0.0486
Echinococcus granulosus tubulin delta chain 0.0498 0.1824 0.1813
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Echinococcus multilocularis tubulin gamma 1 chain 0.1148 0.4314 0.4306
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0169 0.0561 0.0714
Schistosoma mansoni paired box protein pax-6 0.0028 0.0021 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.0142 0.0457 0.0444
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0142 0.0457 0.0595
Trypanosoma cruzi PAB1-binding protein , putative 0.0207 0.0707 0.0904
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0324 0.031
Brugia malayi MH1 domain containing protein 0.0056 0.013 0.017
Trypanosoma cruzi tubulin gamma chain 0.1148 0.4314 0.5609
Echinococcus granulosus histone acetyltransferase KAT2B 0.0309 0.1098 0.1085
Leishmania major beta tubulin 0.2026 0.768 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.007 0.0072
Trypanosoma brucei trypanothione reductase 0.0053 0.0116 0.0133
Echinococcus granulosus tubulin alpha chain 0.1502 0.5672 0.5666
Plasmodium falciparum alpha tubulin 2 0.1502 0.5672 0.738
Schistosoma mansoni single-minded 0.0054 0.0122 0.0108
Schistosoma mansoni paired box protein pax-6 0.0028 0.0021 0.0007
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0025 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0498 0.1824 0.2361
Echinococcus multilocularis paired box protein pax 6 0.0028 0.0021 0.0007
Brugia malayi PAS domain containing protein 0.0054 0.0122 0.0159
Echinococcus granulosus mothers against decapentaplegic 6 0.0046 0.0089 0.0075
Echinococcus granulosus Tubulin alpha 1 chain 0.1502 0.5672 0.5666
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0189 0.0247
Plasmodium falciparum thioredoxin reductase 0.0053 0.0116 0.0133
Brugia malayi Gooseberry protein 0.0028 0.0021 0.0027
Brugia malayi paired box protein 0.0028 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Echinococcus granulosus tubulin epsilon chain 0.1148 0.4314 0.4306
Echinococcus multilocularis GPCR, family 2 0.0033 0.0041 0.0027
Echinococcus multilocularis mothers against decapentaplegic 6 0.0046 0.0089 0.0075
Brugia malayi bZIP transcription factor family protein 0.0094 0.0273 0.0356
Plasmodium falciparum ataxin-2 like protein, putative 0.0207 0.0707 0.0904
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.016 0.0209
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0149 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0023
Echinococcus multilocularis tubulin subunit TubB 0.1502 0.5672 0.5666
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0068 0.007
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0137 0.0179
Echinococcus multilocularis thymidylate synthase 0.012 0.0374 0.036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.064 0.0626
Loa Loa (eye worm) tubulin alpha-3 chain 0.0852 0.3182 0.4143
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0205 0.0701 0.0913
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0229 0.0793 0.1016
Leishmania major beta tubulin 0.2026 0.768 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0156 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.0305 0.0397
Entamoeba histolytica tubulin family protein 0.2026 0.768 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0229 0.0793 0.1016
Schistosoma mansoni histone deacetylase 1 2 3 0.0205 0.0701 0.0688
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0487 0.1781 0.177
Trypanosoma cruzi histone deacetylase, putative 0.0205 0.0701 0.0897
Echinococcus multilocularis tubulin alpha 3 chain 0.1502 0.5672 0.5666
Schistosoma mansoni nuclear hormone receptor 0.0064 0.016 0.0146
Onchocerca volvulus 0.0265 0.093 0.1687
Leishmania major delta tubulin, putative 0.0498 0.1824 0.2361
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0068 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0142 0.0457 0.0595
Echinococcus multilocularis paired box protein pax 6 0.0028 0.0021 0.0007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.0561 0.0714
Echinococcus multilocularis neuropeptide receptor A26 0.0524 0.1921 0.191
Trichomonas vaginalis tubulin beta chain, putative 0.1502 0.5672 0.738
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.016 0.0146
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Brugia malayi Histone deacetylase family protein 0.0325 0.116 0.151
Mycobacterium leprae conserved hypothetical protein 0.004 0.0068 0.0372
Plasmodium vivax hypothetical protein, conserved 0.004 0.0068 0.007
Brugia malayi thymidylate synthase 0.012 0.0374 0.0487
Plasmodium falciparum tubulin beta chain 0.2026 0.768 1
Schistosoma mansoni Smad4 0.0102 0.0305 0.0292
Schistosoma mansoni tubulin subunit beta 0.2026 0.768 0.7677
Brugia malayi nuclear receptor NHR-88 0.0064 0.016 0.0209
Plasmodium vivax delta tubulin, putative 0.0498 0.1824 0.2361
Schistosoma mansoni tubulin subunit epsilon 0.1148 0.4314 0.4306
Echinococcus granulosus tubulin alpha chain 0.1502 0.5672 0.5666
Leishmania major beta tubulin 0.2026 0.768 1
Brugia malayi Histone deacetylase family protein 0.0325 0.116 0.151
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0142 0.0457 0.0444
Echinococcus multilocularis dihydrofolate reductase 0.0049 0.0101 0.0087
Mycobacterium tuberculosis Conserved protein 0.004 0.0068 0.0372
Leishmania major beta tubulin 0.2026 0.768 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0649 0.2404 0.3117
Echinococcus granulosus Tubulin alpha 1 chain 0.1502 0.5672 0.5666
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0026 0.0034
Leishmania major beta tubulin 0.2026 0.768 1
Loa Loa (eye worm) hypothetical protein 0.0852 0.3182 0.4143
Schistosoma mansoni zinc finger protein 0.0064 0.016 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0142 0.0457 0.0595
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0033
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0212 0.0276
Onchocerca volvulus 0.0047 0.0093 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0142 0.0457 0.0595
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0039 0.0033
Schistosoma mansoni Smad4 0.0046 0.0089 0.0075
Echinococcus multilocularis neuropeptide s receptor 0.0524 0.1921 0.191
Echinococcus multilocularis tubulin alpha chain 0.1502 0.5672 0.5666
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0142 0.0457 0.0595
Schistosoma mansoni smad 0.0046 0.0089 0.0075
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0379 0.0494
Loa Loa (eye worm) pax transcription factor protein 2 0.1461 0.5515 0.7181
Brugia malayi Cell division protein ftsZ 0.0498 0.1824 0.2375
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0317 0.0413
Schistosoma mansoni tubulin subunit beta 0.2026 0.768 0.7677
Leishmania major histone deacetylase, putative 0.0325 0.116 0.1494
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0116 0.0102
Schistosoma mansoni tubulin subunit gamma 0.1148 0.4314 0.4306
Trichomonas vaginalis tubulin epsilon chain, putative 0.2026 0.768 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0142 0.0457 0.0444
Schistosoma mansoni nuclear receptor 0.0064 0.016 0.0146
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Mycobacterium leprae Probable lipase LipE 0.004 0.0068 0.0372
Plasmodium vivax histone deacetylase 2, putative 0.0325 0.116 0.1494
Trypanosoma cruzi histone deacetylase, putative 0.0325 0.116 0.1494
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.0211 0.0197
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0141 0.0453 0.0439
Loa Loa (eye worm) hypothetical protein 0.1003 0.3761 0.4897
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0068 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0068 0.0054
Entamoeba histolytica tubulin alpha-1 chain 0.1502 0.5672 0.738
Brugia malayi mothers against decapentaplegic homolog 3 0.0046 0.0089 0.0116
Onchocerca volvulus 0.0041 0.007 0.0127
Echinococcus multilocularis tubulin alpha chain 0.1502 0.5672 0.5666
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0028 0.0021 0.0008
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0033 0.0044
Mycobacterium tuberculosis Conserved protein 0.004 0.0068 0.0372
Schistosoma mansoni paired box protein pax-1-related 0.0028 0.0021 0.0007
Trypanosoma cruzi histone deacetylase, putative 0.0205 0.0701 0.0897
Loa Loa (eye worm) DR-78 0.0064 0.016 0.0209
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0044 0.003
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0026 0.0014 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0142 0.0457 0.0444
Loa Loa (eye worm) tubulin alpha 2 0.1003 0.3761 0.4897
Onchocerca volvulus 0.0064 0.016 0.0291
Schistosoma mansoni hypothetical protein 0.0033 0.0041 0.0027
Leishmania major beta tubulin 0.2026 0.768 1
Echinococcus granulosus tubulin alpha chain 0.1502 0.5672 0.5666
Schistosoma mansoni hypothetical protein 0.0033 0.0041 0.0027
Toxoplasma gondii beta tubulin 0.2026 0.768 1
Toxoplasma gondii LsmAD domain-containing protein 0.0207 0.0707 0.0904
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0025 0.0014
Onchocerca volvulus 0.0028 0.0021 0.0038
Onchocerca volvulus Histone deacetylase 10 homolog 0.0205 0.0701 0.1272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0044 0.003
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0039 0.0033
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0592 0.2182 0.2828
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0179 0.0165
Entamoeba histolytica tartrate dehydrogenase, putative 0.0028 0.0021 0.0008
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0142 0.0457 0.0595
Loa Loa (eye worm) nuclear hormone receptor 0.0064 0.016 0.0209
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0046 0.0089 0.0161
Toxoplasma gondii beta-1 tubulin, putative 0.2026 0.768 1
Mycobacterium ulcerans beta-lactamase 0.004 0.0068 0.0372
Echinococcus multilocularis beta tubulin 0.2026 0.768 0.7677
Echinococcus granulosus lamin dm0 0.0058 0.0137 0.0123
Entamoeba histolytica hypothetical protein 0.0487 0.1781 0.2305
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0039 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0068 0.0372
Echinococcus granulosus mothers against decapentaplegic 2 0.0046 0.0089 0.0075
Trichomonas vaginalis tubulin gamma chain, putative 0.2026 0.768 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0142 0.0457 0.0444
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0068 0.0372
Echinococcus multilocularis histone deacetylase 8 0.0205 0.0701 0.0688
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0211 0.0274
Loa Loa (eye worm) hypothetical protein 0.0086 0.0242 0.0315
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Onchocerca volvulus 0.0058 0.0137 0.0249
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0028 0.0021 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0068 0.007
Echinococcus granulosus tubulin alpha 3 chain 0.1502 0.5672 0.5666
Plasmodium falciparum histone deacetylase 1 0.0592 0.2182 0.2828
Brugia malayi nuclear receptor RXR 0.0077 0.0211 0.0274
Trichomonas vaginalis tubulin alpha chain, putative 0.1148 0.4314 0.5609
Entamoeba histolytica tubulin family protein 0.2026 0.768 1
Loa Loa (eye worm) histone deacetylase 1 0.0592 0.2182 0.2841
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0229 0.0793 0.078
Loa Loa (eye worm) hypothetical protein 0.0312 0.1108 0.1443
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.0427 0.234
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0229 0.0793 0.1016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0142 0.0457 0.0595
Schistosoma mansoni chromobox protein 0.0078 0.0212 0.0198
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0026 0.0016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0142 0.0457 0.0444
Plasmodium falciparum histone deacetylase 2 0.0325 0.116 0.1494
Trichomonas vaginalis tubulin epsilon chain, putative 0.1502 0.5672 0.738
Brugia malayi tubulin alpha chain - mouse 0.1502 0.5672 0.7385
Trichomonas vaginalis conserved hypothetical protein 0.0498 0.1824 0.2361
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0026 0.0014 0.0018
Mycobacterium ulcerans putative regulatory protein 0.004 0.0068 0.0372
Trichomonas vaginalis esterase, putative 0.004 0.0068 0.007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0317 0.0413
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0088
Trichomonas vaginalis tubulin, putative 0.2026 0.768 1
Leishmania major beta tubulin 0.2026 0.768 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0375 0.2058
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0141 0.0453 0.0439
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0379 0.0494
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0229 0.0793 0.1016
Trichomonas vaginalis histone deacetylase, putative 0.0592 0.2182 0.2828
Plasmodium vivax histone deacetylase 1, putative 0.0592 0.2182 0.2828
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0057 0.0133 0.0155
Chlamydia trachomatis endonuclease IV 0.0086 0.0242 1
Loa Loa (eye worm) histone deacetylase 3 0.0592 0.2182 0.2841
Leishmania major beta tubulin 0.2026 0.768 1
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0379 0.0365
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0025 0.0014
Trichomonas vaginalis tubulin epsilon chain, putative 0.2026 0.768 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0049 0.0101 0.0555
Echinococcus multilocularis Tubulin alpha 1 chain 0.1502 0.5672 0.5666
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0379 0.0365
Echinococcus multilocularis chromobox protein 1 0.0078 0.0212 0.0198
Leishmania major gamma-tubulin 0.1148 0.4314 0.5609
Schistosoma mansoni unc-13 (munc13) 0.0028 0.0021 0.0006
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0086 0.0242 0.0315
Echinococcus multilocularis musashi 0.0058 0.0137 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0379 0.0476
Brugia malayi Nuclear hormone receptor E75 0.0064 0.016 0.0209
Schistosoma mansoni smad1 5 8 and 0.0102 0.0305 0.0292
Loa Loa (eye worm) hypothetical protein 0.0105 0.0317 0.0413
Trichomonas vaginalis tubulin beta chain, putative 0.0649 0.2404 0.3117
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0028 0.0021 0.0112
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.032 0.1139 0.1127
Echinococcus granulosus histone deacetylase 7 0.0325 0.116 0.1147
Echinococcus granulosus Smad4 0.0102 0.0305 0.0292
Giardia lamblia Beta tubulin 0.2026 0.768 1
Loa Loa (eye worm) vab-3 0.0028 0.0021 0.0027
Echinococcus granulosus GPCR family 2 0.0033 0.0041 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0037 0.0023
Echinococcus granulosus ecdysone induced protein 78C 0.0142 0.0457 0.0444
Toxoplasma gondii alpha-tubulin I, putative 0.1502 0.5672 0.738
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0028 0.0021 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.0142 0.0457 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0142 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0058 0.0137 0.0179
Trichomonas vaginalis tubulin beta chain, putative 0.1502 0.5672 0.738
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0247
Loa Loa (eye worm) tubulin alpha 2 0.0354 0.1271 0.1655
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0026 0.0016
Leishmania major beta tubulin 0.2026 0.768 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0025 0.0014
Echinococcus granulosus tumor protein p63 0.0731 0.2715 0.2704
Toxoplasma gondii histone deacetylase HDAC2 0.0592 0.2182 0.2828
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0049 0.0101 0.0555
Echinococcus granulosus tubulin alpha 0.1148 0.4314 0.4306
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.0561 0.0714
Plasmodium falciparum alpha tubulin 1 0.1502 0.5672 0.738
Echinococcus multilocularis Tubulin beta 2C chain 0.2026 0.768 0.7677
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0094 0.0104
Schistosoma mansoni lamin 0.0058 0.0137 0.0123
Loa Loa (eye worm) transcription factor SMAD2 0.1499 0.5661 0.7371
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0027
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0375 0.2058
Onchocerca volvulus 0.0107 0.0324 0.0587
Loa Loa (eye worm) hypothetical protein 0.0077 0.0211 0.0274
Echinococcus multilocularis tubulin subunit beta 0.2026 0.768 0.7677
Trypanosoma cruzi histone deacetylase 1, putative 0.0592 0.2182 0.2828
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.0211 0.0197
Echinococcus granulosus histone deacetylase 0.0325 0.116 0.1147
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0116 0.0102
Entamoeba histolytica hypothetical protein 0.0487 0.1781 0.2305
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0064 0.016 0.0146
Trichomonas vaginalis histone deacetylase, putative 0.0592 0.2182 0.2828
Schistosoma mansoni RAR-like nuclear receptor 0.0142 0.0457 0.0444
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.016 0.0146
Trypanosoma brucei histone deacetylase 2 0.0205 0.0701 0.0897
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.016 0.0146
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1502 0.5672 0.738
Brugia malayi phosphofructokinase 0.0121 0.0379 0.0494
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0149 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0088
Loa Loa (eye worm) CBP-B 0.0086 0.0245 0.0319
Leishmania major trypanothione reductase 0.0053 0.0116 0.0133
Echinococcus multilocularis beta tubulin 0.2026 0.768 0.7677
Brugia malayi beta-lactamase 0.004 0.0068 0.0088
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0379 0.1903
Echinococcus granulosus Tubulin beta 2C chain 0.2026 0.768 0.7677
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0116 0.0637
Loa Loa (eye worm) hypothetical protein 0.0044 0.0081 0.0105
Leishmania major beta tubulin 0.2026 0.768 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0211 0.0274
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Trypanosoma brucei alpha tubulin 0.1502 0.5672 0.738
Trichomonas vaginalis tubulin alpha chain, putative 0.0649 0.2404 0.3117
Schistosoma mansoni tubulin subunit beta 0.2026 0.768 0.7677
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0028 0.0021 0.0006
Trypanosoma brucei zeta tubulin, putative 0.0498 0.1824 0.2361
Trypanosoma brucei beta tubulin 0.2026 0.768 1
Brugia malayi nuclear hormone receptor 0.0142 0.0457 0.0595
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0121 0.0377 0.0364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.064 0.0626
Trypanosoma brucei alpha tubulin 0.1502 0.5672 0.738
Trypanosoma cruzi tubulin delta chain 0.0498 0.1824 0.2361
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Plasmodium falciparum tubulin epsilon chain, putative 0.1148 0.4314 0.5609
Trichomonas vaginalis tubulin beta chain, putative 0.2026 0.768 1
Echinococcus granulosus beta tubulin 0.2026 0.768 0.7677
Brugia malayi photoreceptor-specific nuclear receptor 0.0142 0.0457 0.0595
Onchocerca volvulus Bile acid receptor homolog 0.0142 0.0457 0.0829
Echinococcus multilocularis tumor protein p63 0.0731 0.2715 0.2704
Brugia malayi Tubulin alpha chain 0.1502 0.5672 0.7385
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0068 0.0054
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0379 0.0365
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0094 0.017
Echinococcus multilocularis peroxisome assembly protein 26 0.1502 0.5672 0.5666
Echinococcus granulosus single minded 2 0.004 0.0068 0.0054
Brugia malayi 6-phosphofructokinase 0.0121 0.0379 0.0494
Leishmania major beta tubulin 0.2026 0.768 1
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0116 0.0133
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0229 0.0793 0.078
Loa Loa (eye worm) tubulin beta-2A chain 0.2026 0.768 1
Echinococcus granulosus tubulin alpha chain 0.1502 0.5672 0.5666
Echinococcus multilocularis cpg binding protein 0.0034 0.0044 0.003
Trichomonas vaginalis tubulin, putative 0.0649 0.2404 0.3117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0081 0.0147
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.007 0.0072
Schistosoma mansoni steroid hormone receptor ad4bp 0.0142 0.0457 0.0444
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.0427 0.234
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0041 0.0027
Mycobacterium tuberculosis Hypothetical protein 0.0057 0.0133 0.0726
Entamoeba histolytica tubulin alpha chain, putative 0.1502 0.5672 0.738
Loa Loa (eye worm) alpha-tubulin 0.1502 0.5672 0.7385
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0026 0.0014 0.0018
Trichomonas vaginalis tubulin gamma chain, putative 0.0498 0.1824 0.2361
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.064 0.0626
Schistosoma mansoni smad1 5 8 and 0.0102 0.0305 0.0292
Treponema pallidum cell division protein FtsZ 0.0498 0.1824 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Leishmania major hypothetical protein, conserved 0.0207 0.0707 0.0904
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0049 0.0101 0.0555
Loa Loa (eye worm) MH2 domain-containing protein 0.1499 0.5661 0.7371
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0068 0.007
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.007 0.0091
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0068 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0142 0.0457 0.0595
Onchocerca volvulus 0.004 0.0068 0.0123
Brugia malayi tailless protein 0.0064 0.016 0.0209
Brugia malayi Tubulin gamma chain 0.1148 0.4314 0.5617
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.007 0.0072
Onchocerca volvulus 0.004 0.0068 0.0123
Echinococcus granulosus jun protein 0.0094 0.0273 0.0259
Trypanosoma brucei alpha tubulin 0.1502 0.5672 0.738
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0095 0.0279 0.0346
Echinococcus multilocularis Tubulin beta 2C chain 0.2026 0.768 0.7677
Echinococcus multilocularis chromobox protein 1 0.0078 0.0212 0.0198
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0207 0.0707 0.0904
Brugia malayi Cytochrome P450 family protein 0.0082 0.0228 0.0297
Trypanosoma brucei alpha tubulin 0.1502 0.5672 0.738
Trichomonas vaginalis tubulin alpha chain, putative 0.2026 0.768 1
Brugia malayi ecdysteroid receptor 0.0142 0.0457 0.0595
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0379 0.0494
Mycobacterium tuberculosis Probable reductase 0.012 0.0375 0.2058
Brugia malayi hypothetical protein 0.0207 0.0707 0.0921
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0041 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0033
Trypanosoma cruzi histone deacetylase, putative 0.0325 0.116 0.1494
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0852 0.3182 0.4132
Loa Loa (eye worm) hypothetical protein 0.0182 0.0612 0.0797
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Schistosoma mansoni cpg binding protein 0.0032 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.1502 0.5672 0.7385
Trichomonas vaginalis tubulin gamma chain, putative 0.1148 0.4314 0.5609
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.0242 0.0297
Brugia malayi Tubulin beta chain 0.0649 0.2404 0.313
Schistosoma mansoni tubulin subunit alpha 0.0498 0.1824 0.1813
Echinococcus multilocularis Tubulin beta 2C chain 0.2026 0.768 0.7677
Loa Loa (eye worm) paired box protein 0.0028 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Brugia malayi Flap endonuclease-1 0.0029 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Schistosoma mansoni intermediate filament proteins 0.0058 0.0137 0.0123
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0026 0.0143
Echinococcus granulosus paired box protein pax 6 0.0028 0.0021 0.0007
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.012 0.0374 0.2048
Schistosoma mansoni tubulin subunit beta 0.2026 0.768 0.7677
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0093 0.027 0.0256
Giardia lamblia Beta tubulin 0.2026 0.768 1
Schistosoma mansoni paired box protein pax-6 0.0028 0.0021 0.0007
Loa Loa (eye worm) tubulin alpha 2 0.1003 0.3761 0.4897
Brugia malayi MH1 domain containing protein 0.0056 0.013 0.017
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0022 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0142 0.0457 0.0444
Brugia malayi beta-tubulin, identical 0.2026 0.768 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1148 0.4314 0.5609
Brugia malayi vab-3 gene. 0.0028 0.0021 0.0027
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0068 0.0372
Echinococcus granulosus histone deacetylase 6 0.0351 0.126 0.1248
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0028 0.0021 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0379 0.0476
Brugia malayi Cytochrome P450 family protein 0.0029 0.0026 0.0034
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.016 0.0209
Loa Loa (eye worm) hypothetical protein 0.0592 0.2182 0.2841
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0898 0.4925
Brugia malayi alpha-tubulin 0.1502 0.5672 0.7385
Trichomonas vaginalis histone deacetylase, putative 0.0592 0.2182 0.2828
Echinococcus multilocularis tubulin beta 1 chain 0.2026 0.768 0.7677
Schistosoma mansoni histone deacetylase 0.0592 0.2182 0.2171
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0169 0.0561 0.0714
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0068 0.0372
Schistosoma mansoni smad1 5 8 and 0.0102 0.0305 0.0292
Echinococcus granulosus tubulin alpha 3 chain 0.1502 0.5672 0.5666
Echinococcus multilocularis tubulin delta chain 0.0498 0.1824 0.1813
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0028 0.0021 0.0027
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0229 0.0793 0.1016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0117 0.0153
Onchocerca volvulus 0.0649 0.2404 0.4358
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0379 0.0476
Giardia lamblia Beta tubulin 0.2026 0.768 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.016 0.0209
Loa Loa (eye worm) MH1 domain-containing protein 0.0102 0.0305 0.0397
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0026 0.0014 0.0026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0044 0.003
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0026 0.0034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.007 0.0272
Schistosoma mansoni hypothetical protein 0.0033 0.0041 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0142 0.0457 0.0444
Loa Loa (eye worm) beta-tubulin 0.2026 0.768 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1003 0.3761 0.4888
Toxoplasma gondii histone deacetylase HDAC5 0.0205 0.0701 0.0897
Schistosoma mansoni alpha tubulin 0.1502 0.5672 0.5666
Echinococcus granulosus beta tubulin 0.2026 0.768 0.7677
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0149 0.0136
Echinococcus granulosus cpg binding protein 0.0034 0.0044 0.003
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0379 0.2078
Plasmodium vivax tubulin gamma chain, putative 0.1148 0.4314 0.5609
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0379 0.0476
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0498 0.1824 0.2361
Echinococcus granulosus FTZ F1 alpha 0.0142 0.0457 0.0444
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0026 0.0014 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0094 0.0273 0.0259
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0252 0.0879 0.0866
Toxoplasma gondii exonuclease III APE 0.0041 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0027
Echinococcus granulosus muscleblind protein 0.0323 0.1152 0.1139
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0142 0.0457 0.0444
Brugia malayi 'Paired box' domain containing protein 0.0028 0.0021 0.0027
Onchocerca volvulus 0.1461 0.5515 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.016 0.0291
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0025 0.0011
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0039 0.0033
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0379 0.2078
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0242 0.0297
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0169 0.0561 0.0714
Onchocerca volvulus 0.0312 0.1108 0.2009
Loa Loa (eye worm) hypothetical protein 0.0146 0.0472 0.0615
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0039 0.0033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.007 0.0072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0211 0.0197
Echinococcus multilocularis tubulin alpha chain 0.1502 0.5672 0.5666
Echinococcus multilocularis histone deacetylase 6 0.0325 0.116 0.1147
Echinococcus multilocularis muscleblind protein 1 0.0323 0.1152 0.1139
Brugia malayi Pre-SET motif family protein 0.0034 0.0044 0.0058
Brugia malayi MH2 domain containing protein 0.0102 0.0305 0.0397
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0379 0.0476
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0379 0.2078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0094 0.0273 0.0259
Brugia malayi Heterochromatin protein 1 0.0078 0.0212 0.0276
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0142 0.0457 0.0595
Plasmodium vivax tubulin beta chain, putative 0.2026 0.768 1
Schistosoma mansoni Smad4 0.0046 0.0089 0.0075
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.016 0.0146
Echinococcus granulosus intermediate filament protein 0.0058 0.0137 0.0123
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0041 0.0054
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.016 0.0146
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0124 0.011
Trypanosoma brucei tubulin delta chain 0.0498 0.1824 0.2361
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0498 0.1824 1
Trypanosoma brucei histone deacetylase 4 0.0325 0.116 0.1494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.064 0.0626
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1003 0.3761 0.4897
Brugia malayi MH2 domain containing protein 0.0046 0.0089 0.0116
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0137 0.0179
Brugia malayi hypothetical protein 0.0064 0.016 0.0209
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0142 0.0457 0.0444
Echinococcus multilocularis histone deacetylase 1 0.0592 0.2182 0.2171
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0229 0.0793 0.1016
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0028 0.0021 0.0112
Schistosoma mansoni alpha tubulin 0.1502 0.5672 0.5666
Mycobacterium ulcerans lipase LipD 0.004 0.0068 0.0372
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0028 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0077 0.0211 0.0274
Mycobacterium ulcerans hypothetical protein 0.004 0.0068 0.0372
Brugia malayi 'Paired box' domain containing protein 0.0028 0.0021 0.0027
Schistosoma mansoni cpg binding protein 0.0034 0.0044 0.003
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Loa Loa (eye worm) hypothetical protein 0.0046 0.0089 0.0116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0317 0.0413
Brugia malayi jmjC domain containing protein 0.0061 0.0149 0.0195
Echinococcus multilocularis mothers against decapentaplegic 2 0.0046 0.0089 0.0075
Echinococcus granulosus neuropeptide receptor A26 0.0524 0.1921 0.191
Onchocerca volvulus 0.0032 0.0037 0.0066
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0026 0.0014 0.0018
Loa Loa (eye worm) dihydrofolate reductase 0.0049 0.0101 0.0132
Schistosoma mansoni tubulin subunit beta 0.0498 0.1824 0.1813
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0189 0.0228
Echinococcus granulosus tubulin beta 1 chain 0.2026 0.768 0.7677
Schistosoma mansoni transcription factor LCR-F1 0.0487 0.1781 0.177
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0028
Loa Loa (eye worm) histone deacetylase 11 0.0205 0.0701 0.0913
Loa Loa (eye worm) steroid hormone receptor 0.0142 0.0457 0.0595
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0156 0.0143
Schistosoma mansoni coup transcription factor 0.0142 0.0457 0.0444
Trypanosoma brucei histone deacetylase 3 0.0325 0.116 0.1494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0142 0.0457 0.0595
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0068 0.007
Onchocerca volvulus 0.0058 0.0137 0.0249
Onchocerca volvulus 0.0064 0.016 0.0291
Trichomonas vaginalis tubulin beta chain, putative 0.1502 0.5672 0.738
Brugia malayi Histone deacetylase 1 0.0592 0.2182 0.2841
Giardia lamblia Alpha-tubulin 0.1502 0.5672 0.738
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0142 0.0457 0.0444
Echinococcus multilocularis tubulin alpha chain 0.1502 0.5672 0.5666
Trypanosoma brucei epsilon tubulin 0.1148 0.4314 0.5609
Plasmodium vivax histone deacetylase, putative 0.0325 0.116 0.1494
Echinococcus multilocularis tubulin alpha 1C chain 0.1502 0.5672 0.5666
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0088
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0375 0.2058
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0028 0.0021 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0142 0.0457 0.0444
Loa Loa (eye worm) nuclear factor I 0.0056 0.013 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.064 0.0626
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0229 0.0793 0.078
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0379 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0044 0.003
Plasmodium vivax tubulin epsilon chain, putative 0.1148 0.4314 0.5609
Leishmania major isocitrate dehydrogenase, putative 0.0028 0.0021 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0142 0.0457 0.0595
Echinococcus multilocularis tubulin epsilon chain 0.1148 0.4314 0.4306
Trypanosoma cruzi zeta tubulin, putative 0.0498 0.1824 0.2361
Trypanosoma cruzi PAB1-binding protein , putative 0.0207 0.0707 0.0904
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0149 0.0136
Trichomonas vaginalis tubulin beta chain, putative 0.1502 0.5672 0.738
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0379 0.0365
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0229 0.0793 0.078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.064 0.0833
Brugia malayi Cytochrome P450 family protein 0.0029 0.0026 0.0034
Brugia malayi Pre-SET motif family protein 0.0233 0.0807 0.1051
Mycobacterium ulcerans thymidylate synthase 0.012 0.0374 0.2048
Echinococcus multilocularis mothers against decapentaplegic 5 0.0102 0.0305 0.0292
Loa Loa (eye worm) hypothetical protein 0.0323 0.1152 0.15
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0229 0.0793 0.4347
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.007 0.0072
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.016 0.0146
Schistosoma mansoni smad 0.0102 0.0305 0.0292
Loa Loa (eye worm) tubulin beta-1 chain 0.2026 0.768 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0033
Brugia malayi steroid hormone receptor 0.0142 0.0457 0.0595
Leishmania major beta tubulin 0.2026 0.768 1
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0592 0.2182 0.2828
Mycobacterium leprae cell division protein FtsZ 0.0498 0.1824 1
Echinococcus granulosus tubulin alpha chain 0.1502 0.5672 0.5666
Echinococcus multilocularis lamin dm0 0.0058 0.0137 0.0123
Echinococcus granulosus CREB binding protein 0.0078 0.0211 0.0197
Echinococcus granulosus tubulin beta 4A class IVa 0.2026 0.768 0.7677
Echinococcus granulosus mothers against decapentaplegic 5 0.0102 0.0305 0.0292
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0068 0.0054
Schistosoma mansoni tubulin subunit alpha 0.1502 0.5672 0.5666
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0025 0.0014
Brugia malayi hypothetical protein 0.0312 0.1108 0.1443
Loa Loa (eye worm) MH1 domain-containing protein 0.0046 0.0089 0.0116
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.007 0.0072
Leishmania major beta tubulin 0.2026 0.768 1
Schistosoma mansoni histone deacetylase 4 5 0.0325 0.116 0.1147
Trichomonas vaginalis tubulin alpha chain, putative 0.0649 0.2404 0.3117
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0068 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0142 0.0457 0.0595
Brugia malayi beta-lactamase family protein 0.004 0.0068 0.0088
Echinococcus multilocularis geminin 0.2631 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0137 0.0179
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0169 0.0561 0.0714
Brugia malayi beta-lactamase family protein 0.004 0.0068 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.007 0.0072
Schistosoma mansoni dihydrofolate reductase 0.0049 0.0101 0.0087
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0026 0.0014 0.0018
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Echinococcus granulosus Tubulin beta 2C chain 0.2026 0.768 0.7677
Leishmania major beta tubulin 0.2026 0.768 1
Brugia malayi p25-alpha family protein 0.0409 0.148 0.1927
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0102 0.0305 0.0292
Toxoplasma gondii alpha tubulin TUBA1 0.1502 0.5672 0.738
Loa Loa (eye worm) hypothetical protein 0.0207 0.0707 0.0921
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0028 0.0021 0.0007
Schistosoma mansoni ap endonuclease 0.0041 0.007 0.0056
Onchocerca volvulus 0.0028 0.0021 0.0038
Schistosoma mansoni ap endonuclease 0.0041 0.007 0.0056
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.016 0.0209
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.007 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0044 0.003
Brugia malayi hypothetical protein 0.0077 0.0211 0.0274
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0026 0.0014 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0142 0.0457 0.0595
Brugia malayi follicle stimulating hormone receptor 0.0267 0.0937 0.1219
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0093 0.0079
Brugia malayi nuclear hormone receptor 0.0064 0.016 0.0209
Brugia malayi histone deacetylase 1 (HD1) 0.0592 0.2182 0.2841
Schistosoma mansoni chromobox protein 0.0078 0.0212 0.0198
Loa Loa (eye worm) alpha-tubulin 0.1502 0.5672 0.7385
Trichomonas vaginalis tubulin gamma chain, putative 0.1148 0.4314 0.5609
Giardia lamblia Epsilon tubulin 0.0498 0.1824 0.2361
Echinococcus granulosus chromobox protein 1 0.0078 0.0212 0.0198
Echinococcus granulosus thymidylate synthase 0.012 0.0374 0.036
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.016 0.0209
Echinococcus multilocularis ecdysone induced protein 78C 0.0142 0.0457 0.0444
Schistosoma mansoni tubulin subunit alpha 0.1502 0.5672 0.5666
Schistosoma mansoni nuclear receptor 0.0064 0.016 0.0146
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0487 0.1781 0.177
Schistosoma mansoni hypothetical protein 0.0141 0.0453 0.0439
Schistosoma mansoni nuclear hormone receptor 0.0142 0.0457 0.0444
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0041 0.0054
Brugia malayi intermediate filament protein 0.0058 0.0137 0.0179
Echinococcus multilocularis jun protein 0.0094 0.0273 0.0259
Trichomonas vaginalis bromodomain-containing protein, putative 0.0095 0.0279 0.0346
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.0937 0.1219
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0116 0.0133
Echinococcus granulosus paired box protein pax 1 0.0028 0.0021 0.0007
Brugia malayi MH2 domain containing protein 0.1499 0.5661 0.7371
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0498 0.1824 0.2361
Plasmodium falciparum histone deacetylase, putative 0.0325 0.116 0.1494
Onchocerca volvulus 0.0142 0.0457 0.0829
Echinococcus multilocularis transcription factor eb 0.0121 0.0376 0.0362
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.0427 0.234
Echinococcus granulosus Tubulin beta 2C chain 0.2026 0.768 0.7677
Echinococcus granulosus dihydrofolate reductase 0.0049 0.0101 0.0087
Trypanosoma brucei epsilon tubulin 0.1148 0.4314 0.5609
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Chlamydia trachomatis dihydrofolate reductase 0.0049 0.0101 0.3056
Echinococcus multilocularis tubulin alpha 3 chain 0.1502 0.5672 0.5666
Echinococcus granulosus tubulin alpha 1C chain 0.1502 0.5672 0.5666
Brugia malayi nuclear receptor RXR 0.0064 0.016 0.0209
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.0211 0.0197
Plasmodium vivax glutathione reductase, putative 0.0053 0.0116 0.0133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0142 0.0457 0.0444
Brugia malayi MH1 domain containing protein 0.0102 0.0305 0.0397
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0229 0.0793 0.1016
Trypanosoma cruzi alpha tubulin, putative 0.1502 0.5672 0.738
Echinococcus multilocularis paired box protein pax 1 0.0028 0.0021 0.0007
Brugia malayi Dihydrofolate reductase 0.0049 0.0101 0.0132
Onchocerca volvulus Protein ultraspiracle homolog 0.0142 0.0457 0.0829
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.0558 0.0727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0142 0.0457 0.0595
Onchocerca volvulus 0.004 0.0068 0.0123
Brugia malayi Nuclear hormone receptor-like 1 0.0142 0.0457 0.0595
Echinococcus multilocularis histone deacetylase 6 0.0351 0.126 0.1248
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.032 0.1139 0.1127
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0102 0.0305 0.0292
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0229 0.0793 0.1016
Schistosoma mansoni hypothetical protein 0.0093 0.027 0.0256
Leishmania major histone deacetylase, putative 0.0325 0.116 0.1494
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0142 0.0457 0.0829
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0068 0.0372
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0094 0.0104
Echinococcus multilocularis histone deacetylase 7 0.0325 0.116 0.1147
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0095 0.0279 0.0346
Trichomonas vaginalis histone deacetylase, putative 0.0592 0.2182 0.2828
Schistosoma mansoni thyroid hormone receptor 0.0282 0.0996 0.0983
Echinococcus granulosus smad 0.0102 0.0305 0.0292
Trichomonas vaginalis tubulin, putative 0.0498 0.1824 0.2361
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0026 0.0034
Echinococcus multilocularis Smad4 0.0102 0.0305 0.0292
Schistosoma mansoni histone deacetylase hda2 0.0205 0.0701 0.0688
Brugia malayi dihydrofolate reductase family protein 0.0049 0.0101 0.0132
Echinococcus granulosus histone deacetylase 6 0.0325 0.116 0.1147
Trypanosoma cruzi tubulin delta chain 0.0498 0.1824 0.2361
Echinococcus multilocularis smad 0.0102 0.0305 0.0292
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0037 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0142 0.0457 0.0595
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0375 0.2058
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Trypanosoma brucei tubulin gamma chain 0.1148 0.4314 0.5609
Schistosoma mansoni histone deacetylase 0.0592 0.2182 0.2171
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0375 0.2058
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0068 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0282 0.0996 0.0983
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.016 0.0146
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0044 0.0039
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.016 0.0291
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0086 0.0242 0.1326
Brugia malayi conserved hypotetical protein 0.0064 0.016 0.0209
Trypanosoma cruzi histone deacetylase, putative 0.0325 0.116 0.1494
Leishmania major beta tubulin 0.2026 0.768 1
Loa Loa (eye worm) thymidylate synthase 0.012 0.0374 0.0487
Loa Loa (eye worm) hypothetical protein 0.0107 0.0324 0.0421
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0025 0.0014
Echinococcus multilocularis Tubulin alpha 1 chain 0.1502 0.5672 0.5666
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0093 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0027
Giardia lamblia Gamma tubulin 0.1148 0.4314 0.5609
Loa Loa (eye worm) hypothetical protein 0.0077 0.0211 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0081 0.0087
Trypanosoma brucei beta tubulin 0.1148 0.4314 0.5609
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0095 0.0279 0.0346
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0039 0.0033
Brugia malayi hypothetical protein 0.0074 0.0196 0.0255
Echinococcus multilocularis lamin 0.0058 0.0137 0.0123
Echinococcus granulosus histone acetyltransferase KAT2B 0.0095 0.0279 0.0266
Trypanosoma brucei beta tubulin 0.2026 0.768 1
Brugia malayi glutathione reductase 0.0053 0.0116 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.064 0.0833
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0375 0.2058
Toxoplasma gondii endonuclease IV APN 0.0086 0.0242 0.0297
Echinococcus multilocularis Tubulin alpha 1 chain 0.1502 0.5672 0.5666
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0033
Schistosoma mansoni histone deacetylase hda2 0.0351 0.126 0.1248
Loa Loa (eye worm) histone deacetylase 0.0325 0.116 0.151
Brugia malayi 'Paired box' domain containing protein 0.0028 0.0021 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.0082 0.0228 0.0297
Brugia malayi acetyltransferase, GNAT family protein 0.032 0.1139 0.1483
Giardia lamblia Histone deacetylase 0.0592 0.2182 0.2828
Trypanosoma cruzi epsilon tubulin, putative 0.1148 0.4314 0.5609
Brugia malayi histone deacetylase 3 (HD3) 0.0592 0.2182 0.2841
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0156 0.0204
Loa Loa (eye worm) histone deacetylase 7A 0.0325 0.116 0.151
Plasmodium falciparum tubulin gamma chain 0.1148 0.4314 0.5609
Echinococcus granulosus tubulin gamma 1 chain 0.1148 0.4314 0.4306
Schistosoma mansoni cpg binding protein 0.0034 0.0044 0.003
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0086 0.0242 0.1326
Entamoeba histolytica hypothetical protein 0.0487 0.1781 0.2305
Mycobacterium tuberculosis Conserved protein 0.004 0.0068 0.0372
Echinococcus granulosus alpha tubulin 0.1502 0.5672 0.5666
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.0211 0.0274
Echinococcus multilocularis histone deacetylase 6 0.0325 0.116 0.1147
Loa Loa (eye worm) tubulin alpha chain 0.1502 0.5672 0.7385
Loa Loa (eye worm) tubulin beta chain 0.2026 0.768 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0229 0.0793 0.078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.007 0.0056
Brugia malayi nuclear receptor NHR-67 0.0064 0.016 0.0209
Trichomonas vaginalis tubulin beta chain, putative 0.1502 0.5672 0.738
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0081 0.0087
Trypanosoma brucei beta tubulin 0.2026 0.768 1
Toxoplasma gondii histone deacetylase HDAC3 0.0592 0.2182 0.2828
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0211 0.0274
Echinococcus multilocularis tubulin alpha 1C chain 0.1502 0.5672 0.5666
Brugia malayi Tubulin beta-1 chain 0.2026 0.768 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0133 0.0155
Schistosoma mansoni hypothetical protein 0.011 0.0335 0.0322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.064 0.0626
Echinococcus granulosus chromobox protein 1 0.0078 0.0212 0.0198
Trypanosoma brucei histone deacetylase, putative 0.0325 0.116 0.1494
Brugia malayi Smad1 0.0102 0.0305 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0142 0.0457 0.0595
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.0242 0.0297
Schistosoma mansoni retinoic acid receptor RXR 0.0252 0.0879 0.0866
Trypanosoma brucei beta tubulin 0.2026 0.768 1
Mycobacterium ulcerans cell division protein FtsZ 0.0498 0.1824 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.2026 0.768 0.7677
Plasmodium vivax ataxin-2 like protein, putative 0.0207 0.0707 0.0904
Mycobacterium ulcerans endonuclease IV 0.0086 0.0242 0.1326
Loa Loa (eye worm) hypothetical protein 0.0077 0.0211 0.0274
Schistosoma mansoni histone deacetylase 4 5 0.0325 0.116 0.1147
Plasmodium falciparum tubulin delta chain, putative 0.0498 0.1824 0.2361
Brugia malayi Isocitrate dehydrogenase 0.0229 0.0793 0.1033
Entamoeba histolytica histone deacetylase, putative 0.0592 0.2182 0.2828
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0427 0.234
Loa Loa (eye worm) tubulin beta-4 chain 0.2026 0.768 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0027
Echinococcus multilocularis CREB binding protein 0.0085 0.0241 0.0227
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0026 0.0014 0.0018
Toxoplasma gondii histone deacetylase HDAC4 0.0205 0.0701 0.0897
Brugia malayi jmjC domain containing protein 0.0063 0.0156 0.0204
Trichomonas vaginalis histone deacetylase, putative 0.0592 0.2182 0.2828
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0068 0.0372
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0156 0.0143
Loa Loa (eye worm) isocitrate dehydrogenase 0.0229 0.0793 0.1033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0142 0.0457 0.0444
Echinococcus granulosus Tubulin beta 2C chain 0.2026 0.768 0.7677
Echinococcus granulosus histone deacetylase 1 0.0592 0.2182 0.2171
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0028 0.0021 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0068 0.007
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0025 0.0014
Leishmania major epsilon tubulin, putative 0.1148 0.4314 0.5609
Schistosoma mansoni alpha tubulin 0.1502 0.5672 0.5666
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0229 0.0793 0.078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0068 0.0054
Schistosoma mansoni tubulin subunit alpha 0.1502 0.5672 0.5666
Loa Loa (eye worm) hypothetical protein 0.0034 0.0045 0.0058
Giardia lamblia Delta tubulin 0.0498 0.1824 0.2361
Brugia malayi Probable isocitrate dehydrogenase 0.0028 0.0021 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0229 0.0793 0.1016
Brugia malayi nuclear receptor NHR-88 0.0142 0.0457 0.0595
Trichomonas vaginalis tubulin, putative 0.0649 0.2404 0.3117
Schistosoma mansoni hypothetical protein 0.0487 0.1781 0.177
Schistosoma mansoni CREB-binding protein 2 0.0121 0.0377 0.0364
Trypanosoma cruzi epsilon tubulin, putative 0.1148 0.4314 0.5609
Mycobacterium tuberculosis Cell division protein FtsZ 0.0498 0.1824 1
Toxoplasma gondii thioredoxin reductase 0.0053 0.0116 0.0133
Brugia malayi Pax transcription factor protein 2 0.1461 0.5515 0.7181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0041 0.0027
Toxoplasma gondii ABC1 family protein 0.004 0.0068 0.007
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.012 0.0374 0.036
Leishmania major beta tubulin 0.2026 0.768 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0041 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0041 0.0054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0142 0.0457 0.0444
Trichomonas vaginalis tubulin epsilon chain, putative 0.0498 0.1824 0.2361
Brugia malayi hypothetical protein 0.0057 0.0133 0.0173
Schistosoma mansoni tubulin subunit beta 0.2026 0.768 0.7677
Echinococcus granulosus transcription factor eb 0.0121 0.0376 0.0362
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0498 0.1824 0.2361
Loa Loa (eye worm) acetyltransferase 0.032 0.1139 0.1483
Echinococcus granulosus histone deacetylase 3 0.0592 0.2182 0.2171
Leishmania major cytochrome p450-like protein 0.0029 0.0026 0.0016
Brugia malayi MH2 domain containing protein 0.0102 0.0305 0.0397
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.007 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0116 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0142 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0058
Echinococcus granulosus flap endonuclease 1 0.0029 0.0025 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0142 0.0457 0.0444
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.016 0.0146
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.016 0.0146
Echinococcus granulosus tubulin subunit TubB 0.1502 0.5672 0.5666
Loa Loa (eye worm) tubulin beta chain 0.0498 0.1824 0.2375
Echinococcus granulosus neuropeptide s receptor 0.0524 0.1921 0.191
Loa Loa (eye worm) hypothetical protein 0.012 0.0374 0.0486
Echinococcus multilocularis hypothetical protein 0.1502 0.5672 0.5666
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0142 0.0457 0.0444
Loa Loa (eye worm) hypothetical protein 0.0323 0.1152 0.15
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0068 0.0088
Trichomonas vaginalis tubulin epsilon chain, putative 0.1502 0.5672 0.738
Schistosoma mansoni lamin 0.0058 0.0137 0.0123
Trypanosoma brucei zeta tubulin 0.0498 0.1824 0.2361
Brugia malayi ecdysone receptor 0.0064 0.016 0.0209
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0142 0.0457 0.0444
Plasmodium vivax histone deacetylase, putative 0.0205 0.0701 0.0897
Trichomonas vaginalis histone deacetylase, putative 0.0592 0.2182 0.2828
Plasmodium vivax SET domain protein, putative 0.0034 0.0044 0.0039
Loa Loa (eye worm) tubulin alpha chain 0.1502 0.5672 0.7385
Schistosoma mansoni hypothetical protein 0.0076 0.0206 0.0192
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0592 0.2182 0.2828
Onchocerca volvulus 0.012 0.0374 0.0678
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0044 0.003
Trypanosoma brucei epsilon tubulin 0.1148 0.4314 0.5609
Brugia malayi hypothetical protein 0.0064 0.016 0.0209
Brugia malayi hypoxia-induced factor 1 0.0168 0.0558 0.0727
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0068 0.0372
Brugia malayi CXXC zinc finger family protein 0.0032 0.0037 0.0048
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0242 0.0297
Trypanosoma brucei histone deacetylase 1 0.0592 0.2182 0.2828
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0039 0.0033
Schistosoma mansoni hypothetical protein 0.2631 1 1
Brugia malayi 6-phosphofructokinase 0.0121 0.0379 0.0494
Schistosoma mansoni hypothetical protein 0.2631 1 1
Brugia malayi Muscleblind-like protein 0.0323 0.1152 0.15
Brugia malayi hypothetical protein 0.0487 0.1781 0.2319
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0095 0.0279 0.0346
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.007 0.0072
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0026 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.007 0.0382
Plasmodium falciparum flap endonuclease 1 0.0029 0.0025 0.0014
Leishmania major histone deacetylase, putative 0.0592 0.2182 0.2828
Trypanosoma cruzi beta tubulin, putative 0.2026 0.768 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0068 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0142 0.0457 0.0444
Echinococcus multilocularis muscleblind protein 0.0323 0.1152 0.1139
Echinococcus granulosus paired box protein pax 6 0.0028 0.0021 0.0007
Loa Loa (eye worm) hypothetical protein 0.0091 0.0263 0.0343
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.007 0.0056
Brugia malayi Nuclear hormone receptor E75 0.0064 0.016 0.0209
Echinococcus granulosus peroxisome assembly protein 26 0.1502 0.5672 0.5666
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0379 0.0476
Loa Loa (eye worm) tubulin alpha-2 chain 0.1502 0.5672 0.7385
Loa Loa (eye worm) Smad1 0.0102 0.0305 0.0397
Leishmania major beta tubulin 0.2026 0.768 1
Onchocerca volvulus 0.0074 0.0196 0.0355
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.016 0.0146
Loa Loa (eye worm) BEN-1 protein 0.2026 0.768 1
Brugia malayi Tubulin alpha-2 chain 0.1502 0.5672 0.7385
Echinococcus granulosus lamin 0.0058 0.0137 0.0123
Echinococcus multilocularis Tubulin beta 2C chain 0.2026 0.768 0.7677
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.016 0.0146
Brugia malayi tubulin alpha-2 chain 0.1502 0.5672 0.7385
Echinococcus granulosus Tubulin beta 2C chain 0.2026 0.768 0.7677
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0212 0.0258
Loa Loa (eye worm) beta-lactamase 0.004 0.0068 0.0088
Leishmania major zeta tubulin, putative 0.0498 0.1824 0.2361
Schistosoma mansoni tubulin subunit beta 0.2026 0.768 0.7677
Entamoeba histolytica tubulin gamma chain 0.1148 0.4314 0.5609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.007 0.0382
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.016 0.0146
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.012 0.0374 0.2048
Loa Loa (eye worm) glutathione reductase 0.0053 0.0116 0.0151
Trichomonas vaginalis set domain proteins, putative 0.0265 0.093 0.1195
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0649 0.2404 0.3117
Brugia malayi Tubulin alpha chain 0.0498 0.1824 0.2375
Loa Loa (eye worm) hypothetical protein 0.012 0.0372 0.0484
Schistosoma mansoni isocitrate dehydrogenase 0.0028 0.0021 0.0006
Schistosoma mansoni tubulin subunit delta 0.0498 0.1824 0.1813
Brugia malayi Probable isocitrate dehydrogenase 0.0028 0.0021 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0282 0.0996 0.0983
Entamoeba histolytica hypothetical protein 0.0487 0.1781 0.2305
Loa Loa (eye worm) BEN-1 protein 0.2026 0.768 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0121 0.0376 0.0489
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0595
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0041 0.0027
Brugia malayi histone deacetylase 11 0.0205 0.0701 0.0913
Brugia malayi chromobox protein homolog 3 0.0044 0.0081 0.0105
Echinococcus granulosus tubulin alpha 1C chain 0.1502 0.5672 0.5666
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.007 0.0169
Brugia malayi MH1 domain containing protein 0.0102 0.0305 0.0397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0142 0.0457 0.0595
Leishmania major beta tubulin 0.2026 0.768 1
Toxoplasma gondii beta-tubulin, putative 0.2026 0.768 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0142 0.0457 0.0595
Plasmodium vivax tubulin alpha chain, putative 0.1502 0.5672 0.738
Brugia malayi TAZ zinc finger family protein 0.0121 0.0377 0.0491
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0068 0.007
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0039 0.0033
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0022 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.0242 0.0297
Trypanosoma cruzi zeta tubulin, putative 0.0498 0.1824 0.2361
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0028 0.0021 0.0006
Brugia malayi isocitrate dehydrogenase 0.0229 0.0793 0.1033
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Trypanosoma brucei alpha tubulin, putative 0.0649 0.2404 0.3117
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.016 0.0146
Brugia malayi hypothetical protein 0.0182 0.0612 0.0797
Echinococcus multilocularis paired box protein pax 6 0.0028 0.0021 0.0007
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0028 0.0021 0.0027
Echinococcus granulosus Tubulin alpha 1 chain 0.1502 0.5672 0.5666
Giardia lamblia Alpha-tubulin 0.1502 0.5672 0.738
Loa Loa (eye worm) hypothetical protein 0.0064 0.016 0.0209
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0028 0.0021 0.0027
Leishmania major histone deacetylase, putative 0.0592 0.2182 0.2828
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.016 0.0209
Trypanosoma cruzi histone deacetylase 1, putative 0.0592 0.2182 0.2828
Brugia malayi Tubulin beta chain 0.0498 0.1824 0.2375
Echinococcus granulosus TGF beta signal transducer SmadC 0.0102 0.0305 0.0292
Schistosoma mansoni hypothetical protein 0.0033 0.0041 0.0027
Leishmania major alpha tubulin 0.1502 0.5672 0.738
Echinococcus multilocularis tubulin alpha chain 0.1502 0.5672 0.5666

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 272 nM Displacement of [3H]histamine from recombinant human histamine H4 receptor ChEMBL. 21920744

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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