Detailed information for compound 1622780

Basic information

Technical information
  • TDR Targets ID: 1622780
  • Name: ethyl N-[4-[(4-bromophenyl)sulfamoyl]phenyl]c arbamate
  • MW: 399.26 | Formula: C15H15BrN2O4S
  • H donors: 2 H acceptors: 3 LogP: 3.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)Br
  • InChi: 1S/C15H15BrN2O4S/c1-2-22-15(19)17-12-7-9-14(10-8-12)23(20,21)18-13-5-3-11(16)4-6-13/h3-10,18H,2H2,1H3,(H,17,19)
  • InChiKey: MEFLRTKTXNHKIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[(4-bromophenyl)sulfamoyl]phenyl]carbamic acid ethyl ester
  • NSC720736
  • BAS 00508180
  • [4-(4-Bromo-phenylsulfamoyl)-phenyl]-carbamic acid ethyl ester
  • NCI60_041386
  • ZINC00830256

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Brugia malayi kinase, mitochondrial precursor 0.207 0.4878 1
Brugia malayi TAR-binding protein 0.006 0.0106 0.0214
Plasmodium falciparum metacaspase 1 0.0018 0.0007 0.0241
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0012 0.0254
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0047 0.0077 0.319
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0088 0.0138
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0003 0.0004
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0088 0.0135
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0005
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.004 0.0061
Echinococcus multilocularis caspase 2 0.006 0.0106 0.0105
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Leishmania major cathepsin L-like protease 0.0016 0.0001 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Brugia malayi Inositol-1 0.0078 0.0149 0.0302
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.0694 0.1422
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0012 0.0478
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trypanosoma cruzi heat shock protein 90, putative 0.0115 0.0237 0.0487
Plasmodium vivax acyl-CoA synthetase, putative 0.0033 0.0043 0.1756
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0088 0.0086
Echinococcus multilocularis cpg binding protein 0.0125 0.026 0.0259
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0115 0.0237 0.1465
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0237 1
Loa Loa (eye worm) Smad1 0.0017 0.0003 0.0004
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0007 0.0014
Echinococcus granulosus tar DNA binding protein 0.006 0.0106 0.0164
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0002 0.0001
Giardia lamblia Pms1-like protein 0.0115 0.0237 1
Brugia malayi hypothetical protein 0.0248 0.0554 0.1133
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.207 0.4878 0.7663
Echinococcus multilocularis neuropeptide s receptor 0.0906 0.2114 0.2113
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0067 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.0561 0.1148
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0002 0.0001
Brugia malayi Cathepsin L-like precursor 0.0016 0.0001 0.00000030421
Trichomonas vaginalis heat shock protein, putative 0.0115 0.0237 0.1465
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0088 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Trypanosoma brucei DNA topoisomerase ii 0.0115 0.0237 0.0487
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.0451 0.045
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0105 0.0212
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.007 0.1913
Brugia malayi Pre-SET motif family protein 0.061 0.1412 0.2893
Schistosoma mansoni intermediate filament proteins 0.0029 0.0034 0.0053
Brugia malayi heat shock protein 90 0.0115 0.0237 0.0484
Loa Loa (eye worm) hypothetical protein 0.0044 0.007 0.014
Schistosoma mansoni hypothetical protein 0.008 0.0153 0.024
Mycobacterium tuberculosis Probable reductase 0.011 0.0225 0.6412
Echinococcus granulosus smad 0.0017 0.0003 0.0003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0115 0.0237 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0002 0.0001
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0002 0.0003
Brugia malayi Cathepsin L-like precursor 0.0016 0.0001 0.00000030421
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Loa Loa (eye worm) hypothetical protein 0.006 0.0106 0.0215
Leishmania major cathepsin L-like protease 0.0016 0.0001 0.0003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0004 0.0011
Schistosoma mansoni zinc finger protein 0.0026 0.0026 0.0041
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0225 0.6412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.0847 0.1329
Plasmodium falciparum DNA topoisomerase 2 0.0115 0.0237 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0149 0.0305
Chlamydia trachomatis DNA gyrase subunit B 0.0115 0.0237 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0033
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.207 0.4878 0.4878
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0069 0.0129 0.0264
Echinococcus granulosus mitogen activated protein kinase 0.0111 0.0228 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0265 0.0415
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0115 0.0237 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0115 0.0237 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0115 0.0237 0.6781
Leishmania major 4-coumarate:coa ligase-like protein 0.0044 0.007 0.0143
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0127
Schistosoma mansoni survival motor neuron protein 0.0051 0.0084 0.0132
Schistosoma mansoni hypothetical protein 0.008 0.0153 0.024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.004 0.0039
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.007 0.1913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Leishmania major cathepsin L-like protease 0.006 0.0107 0.0219
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0002 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0254 0.7256
Echinococcus multilocularis smad 0.0017 0.0003 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.0047 0.0077 0.0385
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0077 0.32
Leishmania major hypothetical protein, conserved 0.0115 0.0237 0.0487
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0115 0.0237 0.6781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0007 0.0027
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0006
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0111 0.0228 0.0467
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0049 0.0074
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0012 0.0025
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0007 0.0027
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0115 0.0237 0.6781
Leishmania major hypothetical protein, conserved 0.0047 0.0077 0.0157
Brugia malayi Smad1 0.0017 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0177 0.0898
Echinococcus granulosus Smad4 0.0017 0.0003 0.0003
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0002 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0265 0.7594
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0225 0.6412
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0103 0.0161
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0115 0.0237 0.6781
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0115 0.0237 0.0487
Schistosoma mansoni hypothetical protein 0.0347 0.0788 0.1238
Loa Loa (eye worm) hypothetical protein 0.0052 0.0088 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.00000030421
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.004 0.0061
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0002 0.0003
Mycobacterium ulcerans two component sensor kinase MprB 0.0115 0.0237 0.6781
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0004 0.0013
Toxoplasma gondii heat shock protein HSP90 0.0115 0.0237 0.1207
Loa Loa (eye worm) hypothetical protein 0.0107 0.0217 0.0442
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0149 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0129 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Echinococcus granulosus heat shock protein 90 0.0115 0.0237 0.0371
Loa Loa (eye worm) ctsf protein 0.0016 0.0001 0.00000030421
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0115 0.0237 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0115 0.0237 0.1207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0007
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0034 0.0067
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0007 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0228 0.1407
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0003
Trypanosoma cruzi metacaspase, putative 0.0018 0.0007 0.0014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.013 0.3258
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0115 0.0237 0.6781
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0156
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0111 0.0228 0.0467
Brugia malayi Muscleblind-like protein 0.0152 0.0325 0.0663
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0004 0.0006
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Onchocerca volvulus 0.0052 0.0088 0.0535
Loa Loa (eye worm) hypothetical protein 0.207 0.4878 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0004 0.0004
Trypanosoma brucei developmentally regulated phosphoprotein 0.207 0.4878 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0003 0.0005
Brugia malayi intermediate filament protein 0.0029 0.0034 0.0067
Toxoplasma gondii DNA topoisomerase 2, putative 0.0115 0.0237 0.1207
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Trypanosoma brucei metacaspase MCA3 0.0018 0.0007 0.0014
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Plasmodium vivax DNA gyrase subunit B, putative 0.0115 0.0237 1
Brugia malayi hypothetical protein 0.0042 0.0064 0.0127
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0001 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0177 0.0175
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0106 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0011
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0724 0.1682 0.3448
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0001 0.00000030421
Echinococcus multilocularis mitogen activated protein kinase 0.0111 0.0228 0.0227
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0001 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0069 0.0129 0.0264
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0724 0.1682 0.3448
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0007 0.0014
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0088 0.0535
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0003
Echinococcus granulosus GPCR family 2 0.008 0.0153 0.0238
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0012 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.0561 0.1148
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0265 0.0544
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0085
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0002
Mycobacterium ulcerans hypothetical protein 0.0162 0.0348 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.012 0.0187
Giardia lamblia DINP protein human, muc B family 0.002 0.0012 0.0375
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0004
Trypanosoma cruzi metacaspase, putative 0.0018 0.0007 0.0014
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0012 0.0025
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Toxoplasma gondii heat shock protein 90, putative 0.0115 0.0237 0.1207
Echinococcus multilocularis Smad4 0.0017 0.0003 0.0002
Brugia malayi MAP kinase sur-1 0.0111 0.0228 0.0465
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0078 0.016
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0372 0.0761
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0265 0.7594
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.0561 0.1148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0033 0.0043 0.1139
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0149 0.0916
Schistosoma mansoni hypothetical protein 0.0316 0.0715 0.1124
Trypanosoma brucei Heat shock protein 83, putative 0.0115 0.0237 0.0487
Trypanosoma brucei metacaspase MCA2 0.0018 0.0007 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.007 0.1913
Schistosoma mansoni lamin 0.0029 0.0034 0.0053
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.0451 0.0706
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0088 0.0177
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0115 0.0237 0.1465
Entamoeba histolytica acyl-coA synthetase, putative 0.0044 0.007 0.2898
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0033 0.0043 0.1139
Schistosoma mansoni inositol monophosphatase 0.0078 0.0149 0.0234
Plasmodium falciparum metacaspase-like protein 0.0018 0.0007 0.0241
Trypanosoma brucei heat shock protein 90, putative 0.0115 0.0237 0.0487
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0002 0.0003
Schistosoma mansoni pyruvate dehydrogenase 0.207 0.4878 0.7664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0007 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0156
Mycobacterium leprae Probable two-component sensor kinase 0.0115 0.0237 0.9111
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0007 0.0011
Brugia malayi Cathepsin L-like precursor 0.0016 0.0001 0.00000030421
Trichomonas vaginalis receptor histidine kinase, putative 0.0115 0.0237 0.1465
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0111 0.0228 0.116
Plasmodium falciparum thioredoxin reductase 0.0048 0.0078 0.3267
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0004 0.0007
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0115 0.0237 0.0484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.0847 0.1331
Schistosoma mansoni cpg binding protein 0.0125 0.026 0.0409
Toxoplasma gondii thioredoxin reductase 0.0048 0.0078 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.0847 0.1329
Loa Loa (eye worm) heat shock protein 90 0.0115 0.0237 0.0484
Loa Loa (eye worm) hypothetical protein 0.0252 0.0561 0.1148
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0077 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Echinococcus multilocularis musashi 0.0029 0.0034 0.0032
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trichomonas vaginalis receptor histidine kinase, putative 0.0115 0.0237 0.1465
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0225 0.6412
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0033
Brugia malayi Cell death protein 3 precursor 0.006 0.0106 0.0215
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0108
Schistosoma mansoni hypothetical protein 0.008 0.0153 0.024
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0149 0.0305
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0078 0.2166
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0106 0.0167
Echinococcus granulosus mitogen activated protein kinase 3 0.0111 0.0228 0.0356
Schistosoma mansoni myst-related protein 0.0016 0.0001 0.0002
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0002 0.0001
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0115 0.0237 0.6781
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.0217 0.0339
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0057 0.0056
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0149 0.4216
Echinococcus multilocularis caspase 0.0018 0.0007 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0044 0.007 0.1913
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0106 0.0214
Brugia malayi Cathepsin L-like precursor 0.0016 0.0001 0.00000030421
Onchocerca volvulus 0.0694 0.1611 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0004 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0001 0.0015
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0115 0.0237 0.0371
Mycobacterium leprae Probable two component sensor kinase MprB 0.0115 0.0237 0.9111
Trypanosoma cruzi heat shock protein 85, putative 0.0115 0.0237 0.0487
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0013 0.0023
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0309 0.0634
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0111 0.0228 0.0467
Schistosoma mansoni cpg binding protein 0.0116 0.024 0.0377
Echinococcus multilocularis geminin 0.0347 0.0788 0.0786
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.0107 0.0219
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0115 0.0237 0.6781
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0049 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0225 0.6412
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0012 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0044 0.007 0.1913
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0103 0.0159
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.013 0.3654
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0103 0.2873
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0069 0.0129 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Trypanosoma cruzi heat shock protein 90, putative 0.0115 0.0237 0.0487
Brugia malayi glutathione reductase 0.0048 0.0078 0.0158
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0089 0.0183
Echinococcus multilocularis muscleblind protein 0.0152 0.0325 0.0324
Echinococcus granulosus zinc finger protein 0.0026 0.0026 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0027 0.0156
Trypanosoma cruzi Heat shock protein 83, putative 0.0115 0.0237 0.0487
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0115 0.0237 0.9111
Schistosoma mansoni tar DNA-binding protein 0.006 0.0106 0.0166
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0005
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0115 0.0237 0.6781
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0103 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0228 0.1407
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0057 0.0114
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0034 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0153 0.0152
Giardia lamblia Kinase, CMGC MAPK 0.0111 0.0228 0.96
Toxoplasma gondii hypothetical protein 0.005 0.0082 0.0411
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0077 0.0157
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0105 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0007 0.0226
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0004 0.0107
Loa Loa (eye worm) hypothetical protein 0.0115 0.0237 0.0484
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0115 0.0237 0.1465
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0002 0.0001
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0149 0.0916
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0004 0.0092
Onchocerca volvulus 0.009 0.0177 0.109
Trichomonas vaginalis DNA topoisomerase II, putative 0.0115 0.0237 0.1465
Schistosoma mansoni microtubule-associated protein tau 0.2696 0.6365 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0002 0.0003
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0003
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0103 0.0101
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0004
Onchocerca volvulus 0.0016 0.0002 0.0003
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0115 0.0237 0.0487
Schistosoma mansoni myst-related protein 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0116 0.024 0.1483
Loa Loa (eye worm) hypothetical protein 0.0069 0.0129 0.0261
Onchocerca volvulus 0.0051 0.0084 0.0515
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.207 0.4878 0.4878
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0001 0.0015
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0115 0.0237 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0309 0.0634
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0007
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0033 0.0043 0.168
Entamoeba histolytica acyl-CoA synthetase, putative 0.0044 0.007 0.2898
Echinococcus granulosus caspase 2 0.006 0.0106 0.0165
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0002 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0153 0.0152
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0007 0.0008
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0015 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0002 0.0001
Echinococcus granulosus caspase 8 0.0018 0.0007 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0309 0.0634
Echinococcus granulosus expressed protein 0.0016 0.0002 0.0001
Onchocerca volvulus 0.0016 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0077 0.0154
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0011
Brugia malayi Cathepsin L-like precursor 0.0016 0.0001 0.00000030421
Leishmania major mitochondrial DNA topoisomerase II 0.0115 0.0237 0.0487
Mycobacterium ulcerans putative regultory protein 0.0115 0.0237 0.6781
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0111 0.0228 0.0467
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0001 0.0003
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0115 0.0237 0.6781
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0002 0.0001
Plasmodium falciparum thioredoxin reductase 0.0017 0.0004 0.0107
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0004 0.0003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0254 0.7256
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0078 0.3257
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0254 0.7256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.0847 0.1331
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0004 0.0007
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0002 0.0001
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0115 0.0237 0.6781
Echinococcus granulosus neuropeptide receptor A26 0.0906 0.2114 0.332
Trypanosoma brucei unspecified product 0.002 0.0012 0.0025
Trypanosoma brucei heat shock protein 90, putative 0.0115 0.0237 0.0487
Leishmania major 4-coumarate:coa ligase-like protein 0.0044 0.007 0.0143
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0002 0.0001
Echinococcus multilocularis dna polymerase eta 0.002 0.0012 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0554 0.0868
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0069 0.0129 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.0847 0.0846
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0153 0.0238
Mycobacterium tuberculosis Probable two component sensor kinase 0.0115 0.0237 0.6781
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0022
Trypanosoma cruzi DNA topoisomerase II, putative 0.0115 0.0237 0.0487
Brugia malayi AMP-binding enzyme family protein 0.0044 0.007 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0012 0.0254
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0012 0.0254
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.0694 0.1422
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0088 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0177 0.0278
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0033 0.0052
Plasmodium vivax endoplasmin, putative 0.0115 0.0237 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0078 0.016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0039 0.1014
Plasmodium vivax glutathione reductase, putative 0.0048 0.0078 0.3257
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0002 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0906 0.2114 0.2113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0156
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0044 0.007 0.1913
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0106 0.0651
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0002 0.0001
Loa Loa (eye worm) cysteine protease 0.0016 0.0001 0.00000030421
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0033
Loa Loa (eye worm) inositol-1 0.0078 0.0149 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0217 0.0341
Echinococcus multilocularis caspase 8 0.0018 0.0007 0.0005
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0001 0.0015
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0103 0.021
Loa Loa (eye worm) hypothetical protein 0.0248 0.0554 0.1133
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Plasmodium falciparum acyl-CoA synthetase 0.0033 0.0043 0.1769
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trypanosoma brucei metacaspase 0.0018 0.0007 0.0014
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0105 0.0164
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0724 0.1682 0.3448
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0228 0.1407
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.012 0.0119
Trypanosoma brucei Metacaspase-4 0.0018 0.0007 0.0014
Schistosoma mansoni DNA polymerase eta 0.002 0.0012 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.054 0.1105
Mycobacterium ulcerans hypothetical protein 0.0044 0.007 0.1913
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0115 0.0237 0.1465
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.007 0.013 0.0264
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0033 0.0049
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0115 0.0237 0.0487
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.0694 0.1422
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0172 0.0372 0.0585
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0156
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0003
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0069 0.0129 0.0127
Echinococcus multilocularis mitogen activated protein kinase 3 0.0111 0.0228 0.0227
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.0228 0.0467
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0002 0.0003
Onchocerca volvulus 0.0029 0.0034 0.0201
Loa Loa (eye worm) glutathione reductase 0.0048 0.0078 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0217 0.0341
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0265 0.1351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0156
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0265 0.7594
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0149 0.0305
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0839 0.1955 1
Schistosoma mansoni DNA topoisomerase II 0.0115 0.0237 0.0373
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0002 0.0001
Plasmodium vivax metacaspase 1, putative 0.0018 0.0007 0.0226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0039 0.1014
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0149 0.0148
Trichomonas vaginalis sensor histidine kinase, putative 0.0115 0.0237 0.1465
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0001 0.00000030421
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0115 0.0237 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0115 0.0237 0.0484
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0012 0.0254
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.0217 0.0216
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0225 0.8421
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0107 0.0219
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0078 0.0158
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0002 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0067 0.0137
Trypanosoma cruzi metacaspase, putative 0.0018 0.0007 0.0014
Trichomonas vaginalis heat shock protein, putative 0.0115 0.0237 0.1465
Trypanosoma cruzi metacaspase, putative 0.0018 0.0007 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0039 0.1014
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0115 0.0237 0.6781
Trypanosoma brucei PAB1-binding protein , putative 0.0047 0.0077 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0372 0.0847 0.1734
Entamoeba histolytica cysteine protease, putative 0.0016 0.0001 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0039 0.1014
Echinococcus multilocularis lamin dm0 0.0029 0.0034 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0093 0.0188
Leishmania major cathepsin L-like protease 0.0016 0.0001 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0015 0.0021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0254 1
Trypanosoma cruzi heat shock protein 85, putative 0.0115 0.0237 0.0487
Leishmania major DNA topoisomerase ii 0.0115 0.0237 0.0487
Trichomonas vaginalis set domain proteins, putative 0.0694 0.1611 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0012 0.0019
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0002 0.0001
Plasmodium vivax DNA topoisomerase II, putative 0.0115 0.0237 1
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0002 0.0001
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0115 0.0237 0.6781
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0115 0.0237 0.0484
Trichomonas vaginalis helicase, putative 0.0026 0.0027 0.0156
Onchocerca volvulus 0.0016 0.0002 0.0003
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Loa Loa (eye worm) hypothetical protein 0.0172 0.0372 0.0761
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0265 0.0264
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0078 0.0077
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0002 0.0003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0069 0.0129 0.0264
Brugia malayi PHD-finger family protein 0.0031 0.0038 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0085
Schistosoma mansoni tar DNA-binding protein 0.006 0.0106 0.0166
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.002
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0002 0.0001
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0002 0.0001
Schistosoma mansoni cpg binding protein 0.0125 0.026 0.0409
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0152 0.0325 0.0663
Chlamydia trachomatis DNA gyrase subunit B 0.0115 0.0237 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0265 0.7594
Trypanosoma cruzi heat shock protein 85, putative 0.0115 0.0237 0.0487
Echinococcus granulosus ubiquitin specific protease 41 0.0069 0.0129 0.02
Loa Loa (eye worm) fibroinase 0.0016 0.0001 0.00000030421
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0002 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.054 0.1105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.061 0.1412 0.2893
Brugia malayi Endoplasmin precursor 0.0115 0.0237 0.0484
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0069 0.0129 0.0264
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0115 0.0237 0.1465
Echinococcus granulosus lamin dm0 0.0029 0.0034 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0027 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0115 0.0237 0.1465
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.006 0.0121
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0001 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.0163 0.0254
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0025
Brugia malayi Pre-SET motif family protein 0.009 0.0177 0.036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0088 0.0086
Schistosoma mansoni Smad4 0.0017 0.0003 0.0005
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0115 0.0237 0.0487
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0001 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0153 0.0311
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0001 0.00000030421
Schistosoma mansoni hypothetical protein 0.008 0.0153 0.024
Brugia malayi mbt repeat family protein 0.0052 0.0088 0.0177
Plasmodium vivax SET domain protein, putative 0.009 0.0177 0.7437
Brugia malayi RNA binding protein 0.006 0.0106 0.0214
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0044 0.007 0.014
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Loa Loa (eye worm) hypothetical protein 0.0152 0.0325 0.0663
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0007 0.0027
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0554 0.0553
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0084 0.017
Loa Loa (eye worm) TAR-binding protein 0.006 0.0106 0.0214
Mycobacterium ulcerans two component regulator - sensor kinase 0.0115 0.0237 0.6781
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0069 0.0129 0.0202
Brugia malayi mbt repeat family protein 0.0052 0.0088 0.0177
Loa Loa (eye worm) hypothetical protein 0.008 0.0153 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus multilocularis ubiquitin specific protease 41 0.0069 0.0129 0.0127
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0069 0.0129 0.02
Schistosoma mansoni hypothetical protein 0.0778 0.1812 0.2847
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0115 0.0237 0.1465
Leishmania major metacaspase, putative 0.0018 0.0007 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0111 0.0228 0.0467
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0007 0.0011
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0069 0.0129 0.5399
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0348 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Echinococcus granulosus caspase 0.0018 0.0007 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Brugia malayi CXXC zinc finger family protein 0.0116 0.024 0.0489
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Mycobacterium ulcerans DNA gyrase subunit B 0.0115 0.0237 0.6781
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0078 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.007 0.1913
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0105 0.0103
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0044 0.007 0.1913
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0069 0.0129 0.079
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0077 0.32
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Leishmania major cathepsin L-like protease 0.0016 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0044 0.007 0.014
Leishmania major cathepsin L-like protease 0.006 0.0107 0.0219
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0225 0.6412
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0149 0.0916
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0002 0.0003
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0007 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0265 0.0417
Echinococcus multilocularis dna polymerase kappa 0.002 0.0012 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0069 0.0129 0.079
Onchocerca volvulus 0.0042 0.0064 0.0386
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.024 0.0489
Schistosoma mansoni hypothetical protein 0.0051 0.0084 0.0132
Plasmodium falciparum heat shock protein 90 0.0115 0.0237 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0004 0.0092
Onchocerca volvulus 0.0044 0.007 0.0423
Plasmodium vivax heat shock protein 86, putative 0.0115 0.0237 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0149 0.6258
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0012 0.0068
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0115 0.0237 0.1207
Brugia malayi follicle stimulating hormone receptor 0.0474 0.1088 0.2229
Entamoeba histolytica heat shock protein 90, putative 0.0115 0.0237 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0069 0.0129 0.0202
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0002 0.0001
Brugia malayi Latrophilin receptor protein 2 0.008 0.0153 0.0311
Echinococcus granulosus microtubule associated protein 2 0.2696 0.6365 1
Brugia malayi MH2 domain containing protein 0.0243 0.054 0.1105
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0004 0.0007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0004 0.0007
Echinococcus multilocularis zinc finger protein 0.0026 0.0026 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.007 0.1913
Schistosoma mansoni heat shock protein 0.0115 0.0237 0.0373
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0067
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0064 0.0098
Plasmodium falciparum DNA gyrase subunit B 0.0115 0.0237 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.207 0.4878 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Schistosoma mansoni smad 0.0017 0.0003 0.0005
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0069 0.0129 0.5349
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0115 0.0237 0.6781
Schistosoma mansoni bromodomain containing protein 0.0069 0.0129 0.0202
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0149 0.0755
Echinococcus granulosus heat shock protein 0.0115 0.0237 0.0371
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0105 0.0103
Echinococcus granulosus lamin 0.0029 0.0034 0.0051
Plasmodium falciparum glutathione reductase 0.0048 0.0078 0.3267
Schistosoma mansoni hypothetical protein 0.0042 0.0064 0.01
Echinococcus granulosus muscleblind protein 0.0152 0.0325 0.0508
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.004 0.0039
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0044 0.007 0.014
Loa Loa (eye worm) hypothetical protein 0.0044 0.007 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0177 0.0278
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0003 0.0003
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0006 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.0694 0.1422
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0115 0.0237 1
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0149 0.0232
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0153 0.0238
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0111 0.0228 0.0465
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0002 0.0003
Schistosoma mansoni endoplasmin 0.0115 0.0237 0.0373
Schistosoma mansoni lamin 0.0029 0.0034 0.0053
Echinococcus granulosus cpg binding protein 0.0125 0.026 0.0407
Echinococcus multilocularis microtubule associated protein 2 0.2696 0.6365 0.6365
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0115 0.0237 0.1465
Schistosoma mansoni endoplasmin 0.0115 0.0237 0.0373
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0002 0.0037
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0002 0.0003
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0115 0.0237 0.6781
Brugia malayi Probable DNA topoisomerase II 0.0115 0.0237 0.0484
Leishmania major trypanothione reductase 0.0048 0.0078 0.016
Entamoeba histolytica DNA topoisomerase II, putative 0.0115 0.0237 1
Schistosoma mansoni tar DNA-binding protein 0.006 0.0106 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0153 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0033
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0033 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0025
Leishmania major cathepsin L-like protease 0.006 0.0107 0.0219
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0004 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0004 0.0006
Echinococcus granulosus dnaJ subfamily B 0.0778 0.1812 0.2845
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0069 0.0129 0.0127
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0115 0.0237 0.6781
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0004 0.0013
Trypanosoma brucei heat shock protein, putative 0.0115 0.0237 0.0487
Echinococcus granulosus dna polymerase kappa 0.002 0.0012 0.0017
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0325 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.0847 0.1331
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0002 0.0003
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0012 0.0019
Schistosoma mansoni hypothetical protein 0.0347 0.0788 0.1238
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0022
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0067 0.0137
Echinococcus multilocularis expressed protein 0.0016 0.0002 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0044 0.007 0.2898
Schistosoma mansoni pyruvate dehydrogenase 0.1955 0.4605 0.7234
Schistosoma mansoni tar DNA-binding protein 0.006 0.0106 0.0166
Leishmania major cathepsin L-like protease 0.0016 0.0001 0.0003
Plasmodium falciparum glutathione reductase 0.0017 0.0004 0.0107
Trypanosoma cruzi DNA topoisomerase II, putative 0.0115 0.0237 0.0487
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Brugia malayi hypothetical protein 0.0047 0.0077 0.0154
Onchocerca volvulus 0.0017 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0059 0.0105 0.0212
Onchocerca volvulus 0.0029 0.0034 0.0201
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Brugia malayi G-protein alpha subunit 0.0016 0.0002 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0034 0.0067
Entamoeba histolytica heat shock protein 90, putative 0.0115 0.0237 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0372 0.0847 0.1734
Schistosoma mansoni heat shock protein 0.0115 0.0237 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0156
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0103 0.2873
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0103 0.2873
Echinococcus multilocularis dnaJ subfamily B 0.0778 0.1812 0.1811
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0001 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0906 0.2114 0.332
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0265 0.0417
Schistosoma mansoni mixed-lineage leukemia protein mll 0.025 0.0557 0.0876
Echinococcus multilocularis heat shock protein 0.0115 0.0237 0.0236
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0115 0.0237 0.0487
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0017
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0002 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Brugia malayi hypothetical protein 0.0031 0.0037 0.0072
Schistosoma mansoni pyruvate dehydrogenase 0.1955 0.4605 0.7234
Echinococcus granulosus intermediate filament protein 0.0029 0.0034 0.0051
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0004
Brugia malayi Bromodomain containing protein 0.0038 0.0054 0.0108
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0003 0.0004
Trichomonas vaginalis endoplasmin, putative 0.0115 0.0237 0.1465
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0076 0.0156
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0149 0.6218
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0002 0.0001
Loa Loa (eye worm) TOPoisomerase family member 0.0115 0.0237 0.0484
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0007 0.0033
Loa Loa (eye worm) endoplasmin 0.0115 0.0237 0.0484
Schistosoma mansoni tar DNA-binding protein 0.006 0.0106 0.0166
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.207 0.4878 1
Echinococcus multilocularis lamin 0.0029 0.0034 0.0032
Schistosoma mansoni inositol monophosphatase 0.0078 0.0149 0.0234
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0724 0.1682 0.8601
Loa Loa (eye worm) MBCTL1 0.0059 0.0105 0.0212
Leishmania major DNA polymerase kappa, putative 0.002 0.0012 0.0025
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0115 0.0237 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0064 0.0062
Echinococcus granulosus geminin 0.0347 0.0788 0.1236
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0115 0.0237 0.6781
Echinococcus multilocularis heat shock protein 90 0.0115 0.0237 0.0236
Trypanosoma brucei protein kinase, putative 0.0111 0.0228 0.0467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Brugia malayi Bromodomain containing protein 0.0081 0.0156 0.0317
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0115 0.0237 0.0236
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0004 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0067 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.05 0.2553
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0115 0.0237 0.6781
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0022
Brugia malayi Cathepsin L-like precursor 0.0016 0.0001 0.00000030421
Loa Loa (eye worm) RNA binding protein 0.006 0.0106 0.0214
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0228 0.0358
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0105 0.0162
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0115 0.0237 0.6781
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0107 0.0219
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.0228 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0002 0.0003
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.0847 0.0846
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0094 0.0193
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0025
Echinococcus multilocularis tar DNA binding protein 0.006 0.0106 0.0104
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0115 0.0237 0.6781
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0474 0.1088 0.2229
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0115 0.0237 0.9111
Mycobacterium tuberculosis Conserved protein 0.0115 0.0237 0.6781
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0002 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0003 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0044 0.007 0.0143
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0107 0.0219
Loa Loa (eye worm) hypothetical protein 0.0049 0.008 0.0161
Plasmodium falciparum endoplasmin, putative 0.0115 0.0237 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0115 0.0237 0.0487
Leishmania major DNA polymerase eta, putative 0.002 0.0012 0.0025
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0228 0.1407
Mycobacterium tuberculosis Possible two component sensor kinase 0.0115 0.0237 0.6781
Brugia malayi hypothetical protein 0.0016 0.0002 0.0001
Echinococcus multilocularis GPCR, family 2 0.008 0.0153 0.0152
Brugia malayi Thioredoxin reductase 0.0048 0.0078 0.0158
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0057 0.0087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0004 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0107 0.0219
Leishmania major heat shock protein 83-1 0.0115 0.0237 0.0487
Echinococcus granulosus dna polymerase eta 0.002 0.0012 0.0017

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.764 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.733 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.592 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.522 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.508 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.458 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.432 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.36 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.223 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.184 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.131 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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