TDR Targets

Basic information

Technical information

TDR Targets ID: 163585
Name: (Z)-7-phenyl-7-pyridin-4-ylhept-6-enoic acid
MW: 281.349 | Formula: C18H19NO2
H donors: 1 H acceptors: 3 LogP: 4.04 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCC/C=C(\c1ccncc1)/c1ccccc1
InChi: 1S/C18H19NO2/c20-18(21)10-6-2-5-9-17(15-7-3-1-4-8-15)16-11-13-19-14-12-16/h1,3-4,7-9,11-14H,2,5-6,10H2,(H,20,21)/b17-9-
InChiKey: LTONXWVJNJCULL-MFOYZWKCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(Z)-7-phenyl-7-(4-pyridyl)hept-6-enoic acid
(Z)-7-phenyl-7-(4-pyridyl)-6-heptenoic acid
(Z)-7-phenyl-7-pyridin-4-yl-hept-6-enoic acid
isbogrel
93943-87-4
6-Heptenoic acid, 7-phenyl-7-(3-pyridinyl)-
7-Phenyl-7-(3-pyridinyl)-6-heptenoic acid
7-Phenyl-7-(3-pyridyl)-6-heptenoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0073	0.0071	0.0302
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.005	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0073	0.0071	0.0066
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.0024	0.0011
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Echinococcus multilocularis	oxysterol binding protein 3	0.0073	0.0071	0.0078
Toxoplasma gondii	AtPH1 family protein	0.0073	0.0071	0.5384
Brugia malayi	Syntrophin-1	0.0073	0.0071	0.0066
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0073	0.0071	0.0457
Loa Loa (eye worm)	hypothetical protein	0.008	0.0086	0.008
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.005	0.0024	0.0019
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0073	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Brugia malayi	Cytohesin 3	0.0073	0.0071	0.0066
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0092	0.0111	0.0106
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.005	0.0024	0.0022
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0073	0.0071	0.0066
Trichomonas vaginalis	centaurin gamma, putative	0.0073	0.0071	0.0457
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.008	0.0086	0.0096
Brugia malayi	hypothetical protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0079	0.0085	0.0095
Schistosoma mansoni	fibrocystin l	0.015	0.023	0.0217
Schistosoma mansoni	cell adhesion molecule	0.0085	0.0096	0.0083
Brugia malayi	Furin-like cysteine rich region family protein	0.005	0.0024	0.0019
Schistosoma mansoni	regulator of G protein signaling	0.0794	0.1555	0.1544
Loa Loa (eye worm)	sema domain-containing protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Schistosoma mansoni	regulator of G protein signaling	0.0794	0.1555	0.1544
Brugia malayi	hypothetical protein	0.0794	0.1555	0.1551
Brugia malayi	Probable exocyst complex component Sec5	0.015	0.023	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Echinococcus granulosus	tyrosine protein kinase ABL1	0.005	0.0024	0.0022
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.005	0.0024	0.0022
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0079	0.0085	0.0095
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0073	0.0071	0.5384
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0024	0.0022
Echinococcus granulosus	Regulator of G protein signaling 20	0.0794	0.1555	0.1854
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.005	0.0024	0.0022
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0794	0.1555	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0073	0.0071	0.0058
Onchocerca volvulus	Putative zinc finger protein	0.0073	0.0071	0.0302
Loa Loa (eye worm)	serine/threonine protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	defective proboscis extension response	0.008	0.0086	0.0096
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.008	0.0086	0.0072
Trichomonas vaginalis	centaurin/arf, putative	0.0073	0.0071	0.0457
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0073	0.0071	0.0302
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.005	0.0024	0.0019
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0073	0.0071	0.0078
Echinococcus multilocularis	pdz domain containing protein	0.0073	0.0071	0.0078
Echinococcus multilocularis	hypothetical protein	0.0342	0.0626	0.0742
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0073	0.0071	0.0078
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0073	0.0071	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	semaphorin 5B	0.0342	0.0626	0.0742
Brugia malayi	MAX-1A	0.0073	0.0071	0.0066
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Echinococcus multilocularis	tyrosine protein kinase Abl	0.005	0.0024	0.0022
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.005	0.0024	0.0022
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0024	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0073	0.0071	0.0078
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0071	0.0307
Echinococcus multilocularis	FL cytokine receptor	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0073	0.0071	0.0078
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0024	0.0019
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.0024	0.0019
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0794	0.1555	0.1854
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0024	0.0011
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Onchocerca volvulus		0.0073	0.0071	0.0302
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0073	0.0071	0.0078
Brugia malayi	SH2 domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Echinococcus multilocularis	tyrosine kinase	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.015	0.023	0.1478
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.005	0.0024	0.0022
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0073	0.0071	0.5384
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0626	0.0621
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0092	0.0111	1
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0085	0.0544
Loa Loa (eye worm)	hypothetical protein	0.015	0.023	0.0224
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0073	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0111	0.057
Trichomonas vaginalis	kinesin light chain, putative	0.0073	0.0071	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Loa Loa (eye worm)	TK/Met protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	hypothetical protein	0.005	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Schistosoma mansoni	syntrophin	0.0073	0.0071	0.0058
Echinococcus granulosus	tyrosine protein kinase Srms	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	A-kinase anchor protein 10, precursor	0.0794	0.1555	0.1551
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	receptor type guanylyl cyclase	0.005	0.0024	0.0022
Echinococcus multilocularis	tyrosine protein kinase Blk	0.005	0.0024	0.0022
Entamoeba histolytica	PH domain containing protein	0.0073	0.0071	0.0307
Echinococcus granulosus	Immunoglobulin	0.008	0.0086	0.0096
Schistosoma mansoni	growth factor receptor-bound protein	0.0073	0.0071	0.0058
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0092	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.0024	0.0011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.0189	0.0183
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/ACK protein kinase	0.005	0.0024	0.0019
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Trypanosoma cruzi	NIMA-related kinase, putative	0.0092	0.0111	1
Entamoeba histolytica	protein kinase domain containing protein	0.02	0.0333	0.2016
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.005	0.0024	0.0022
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0092	0.0111	1
Leishmania major	hypothetical protein, conserved	0.0073	0.0071	0.5384
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Loa Loa (eye worm)	TK/ROR protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.005	0.0024	0.0019
Onchocerca volvulus		0.0806	0.158	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0024	0.0022
Echinococcus multilocularis	Immunoglobulin	0.008	0.0086	0.0096
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0071	0.0307
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0024	0.0019
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.005	0.0024	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0024	0.0022
Brugia malayi	hypothetical protein	0.0794	0.1555	0.1551
Trichomonas vaginalis	alpha chimerin, putative	0.0073	0.0071	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Onchocerca volvulus		0.0073	0.0071	0.0302
Echinococcus multilocularis	epidermal growth factor receptor	0.005	0.0024	0.0022
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0079	0.0085	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0111	0.057
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.005	0.0024	0.0155
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Echinococcus granulosus	dynamin 1	0.0073	0.0071	0.0078
Entamoeba histolytica	PH domain containing protein	0.0073	0.0071	0.0307
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0073	0.0071	0.0307
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0073	0.0071	0.0078
Loa Loa (eye worm)	Plekhf2 protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0096	0.0091
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.005	0.0024	0.0022
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3752	0.7647	0.914
Entamoeba histolytica	cell surface protease gp63, putative	0.015	0.023	0.1344
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0073	0.0071	0.0078
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0055	0.0035	0.0035
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Brugia malayi	serine/threonine kinase 12	0.0079	0.0085	0.0079
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0073	0.0071	0.0066
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	protein tyrosine kinase	0.005	0.0024	0.0022
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0024	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0794	0.1555	0.1551
Echinococcus granulosus	tyrosine protein kinase shark	0.005	0.0024	0.0022
Toxoplasma gondii	aurora kinase	0.0079	0.0085	0.6933
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0111	0.057
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Entamoeba histolytica	protein kinase domain containing protein	0.007	0.0064	0.0263
Entamoeba histolytica	hypothetical protein	0.0073	0.0071	0.0307
Schistosoma mansoni	hypothetical protein	0.0073	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0794	0.1555	0.1551
Schistosoma mansoni	dynamin	0.0073	0.0071	0.0058
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Schistosoma mansoni	serine/threonine RGC	0.005	0.0024	0.0011
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0079	0.0085	0.6933
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0079	0.0085	0.6933
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trypanosoma cruzi	Protein kinase B	0.0092	0.0111	1
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Entamoeba histolytica	hypothetical protein	0.0794	0.1555	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0111	0.057
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0073	0.0071	0.5384
Echinococcus granulosus	tyrosine kinase	0.005	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.008	0.0086	0.008
Entamoeba histolytica	hypothetical protein	0.0794	0.1555	1
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0073	0.0071	0.0058
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.015	0.023	0.1478
Loa Loa (eye worm)	TK/CSK protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	oxysterol-binding protein 1	0.0073	0.0071	0.0058
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0794	0.1555	0.1854
Echinococcus granulosus	integrin linked protein kinase	0.005	0.0024	0.0022
Echinococcus granulosus	activated cdc42 kinase 1	0.005	0.0024	0.0022
Echinococcus multilocularis	expressed protein	0.0794	0.1555	0.1854
Entamoeba histolytica	protein kinase, putative	0.0079	0.0085	0.0395
Loa Loa (eye worm)	hypothetical protein	0.008	0.0086	0.008
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Echinococcus granulosus	ephrin type A receptor 4 A	0.005	0.0024	0.0022
Schistosoma mansoni	hypothetical protein	0.015	0.023	0.0217
Brugia malayi	hypothetical protein	0.005	0.0024	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Echinococcus granulosus	pdz domain containing protein	0.0073	0.0071	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	actin binding protein anillin	0.0073	0.0071	0.0078
Schistosoma mansoni	hypothetical protein	0.0342	0.0626	0.0613
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	hypothetical protein	0.015	0.023	0.0224
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Brugia malayi	C-terminal src kinase protein 1	0.005	0.0024	0.0019
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0794	0.1555	0.1551
Brugia malayi	PXA domain containing protein	0.0794	0.1555	0.1551
Echinococcus multilocularis	Pleckstrin y	0.0073	0.0071	0.0078
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0794	0.1555	1
Echinococcus granulosus	serine/threonine protein kinase	0.0092	0.0111	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	TK/EPH protein kinase	0.005	0.0024	0.0019
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0073	0.0071	0.0078
Brugia malayi	hypothetical protein	0.005	0.0024	0.0019
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	hypothetical protein	0.015	0.023	0.0217
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.007	0.0064	0.4616
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0092	0.0111	1
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.005	0.0024	0.0022
Echinococcus multilocularis	raf serine:threonine protein kinase	0.005	0.0024	0.0022
Echinococcus granulosus	beta 1 syntrophin	0.0073	0.0071	0.0078
Onchocerca volvulus	outspread protein homolog	0.0073	0.0071	0.0302
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0794	0.1555	0.1854
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.007	0.0064	0.4616
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.005	0.0024	0.0022
Brugia malayi	protein-tyrosine kinase	0.005	0.0024	0.0019
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0073	0.0071	0.5384
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0071	0.0307
Loa Loa (eye worm)	SRC-1	0.005	0.0024	0.0019
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4101	0.8366	0.8365
Loa Loa (eye worm)	syntrophin-1	0.0073	0.0071	0.0066
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0024	0.0022
Schistosoma mansoni	myotubularin-related protein	0.0073	0.0071	0.0058
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0055	0.0035	0.0035
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0024	0.0019
Echinococcus granulosus	roundabout 2	0.0085	0.0096	0.0108
Schistosoma mansoni	hypothetical protein	0.0342	0.0626	0.0613
Echinococcus granulosus	expressed protein	0.0794	0.1555	0.1854
Brugia malayi	Uncoordinated protein 104	0.0073	0.0071	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Echinococcus granulosus	protein kinase	0.005	0.0024	0.0022
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3752	0.7647	0.7645
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Entamoeba histolytica	hypothetical protein	0.0092	0.0111	0.057
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Plasmodium falciparum	oxysterol-binding protein, putative	0.0073	0.0071	0.5384
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Brugia malayi	Dynamin	0.0073	0.0071	0.0066
Echinococcus multilocularis	cytohesin 1	0.0073	0.0071	0.0078
Brugia malayi	Plekhf2 protein	0.0073	0.0071	0.0066
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0073	0.0071	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.0024	0.0011
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0073	0.0071	0.0457
Schistosoma mansoni	hypothetical protein	0.0073	0.0071	0.0058
Echinococcus granulosus	insulin receptor	0.005	0.0024	0.0022
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0092	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0626	0.0621
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.005	0.0024	0.0022
Onchocerca volvulus	Protein melted homolog	0.0073	0.0071	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0092	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.007	0.0064	0.007
Echinococcus granulosus	semaphorin 5B	0.0342	0.0626	0.0742
Echinococcus granulosus	cytohesin 1	0.0073	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.005	0.0024	0.0019
Brugia malayi	Dynamin	0.0073	0.0071	0.0066
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0071	0.5384
Brugia malayi	PXA domain containing protein	0.0794	0.1555	0.1551
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0111	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4101	0.8366	0.8365
Entamoeba histolytica	protein kinase , putative	0.0079	0.0085	0.0395
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Echinococcus multilocularis	tyrosine protein kinase pr2	0.005	0.0024	0.0022
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Brugia malayi	regulator of G-protein signaling rgs-7	0.0794	0.1555	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0794	0.1555	0.1551
Echinococcus multilocularis	regulator of G protein signaling 7	0.0794	0.1555	0.1854
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0085	0.0544
Loa Loa (eye worm)	AUR protein kinase	0.0079	0.0085	0.0079
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0071	0.0307
Brugia malayi	hypothetical protein	0.0085	0.0096	0.0091
Onchocerca volvulus		0.0073	0.0071	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0382	0.0377
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0092	0.0111	1
Entamoeba histolytica	hypothetical protein	0.0073	0.0071	0.0307
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0073	0.0071	0.0307
Trichomonas vaginalis	hypothetical protein	0.0073	0.0071	0.0457
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0073	0.0071	0.5384
Echinococcus multilocularis	kinase suppressor of Ras 1	0.005	0.0024	0.0022
Echinococcus granulosus	pleckstrin y domain containing family A	0.0073	0.0071	0.0078
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.005	0.0024	0.0155
Entamoeba histolytica	hypothetical protein	0.0073	0.0071	0.0307
Brugia malayi	IPT/TIG domain containing protein	0.015	0.023	0.0224
Brugia malayi	SH2 domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Leishmania major	protein kinase, putative	0.0079	0.0085	0.6933
Schistosoma mansoni	goodpasture antigen-binding protein	0.0073	0.0071	0.0058
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	c src tyrosine kinase	0.005	0.0024	0.0022
Brugia malayi	Sema domain containing protein	0.0342	0.0626	0.0621
Brugia malayi	Guanylyl cyclase protein 23	0.005	0.0024	0.0019
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0794	0.1555	0.1544
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Trichomonas vaginalis	TK family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Leishmania major	folate/biopterin transporter, putative	0.0092	0.0111	1
Echinococcus multilocularis	oxysterol binding protein 9	0.0073	0.0071	0.0078
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.005	0.0024	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.015	0.023	0.1478
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.005	0.0024	0.0155
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0073	0.0071	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Schistosoma mansoni	ephrin receptor	0.0055	0.0035	0.0021
Trypanosoma brucei	protein kinase, putative	0.0092	0.0111	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0092	0.0111	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0794	0.1555	0.1551
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0092	0.0111	1
Echinococcus multilocularis	protein kinase	0.005	0.0024	0.0022
Echinococcus multilocularis	exocyst complex component 2	0.015	0.023	0.0268
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Toxoplasma gondii	hypothetical protein	0.0073	0.0071	0.5384
Giardia lamblia	Aurora kinase	0.0079	0.0085	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0086	0.008
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Schistosoma mansoni	protein kinase	0.0079	0.0085	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Loa Loa (eye worm)	TK/ALK protein kinase	0.0304	0.0548	0.0542
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.005	0.0024	0.0022
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.005	0.0024	0.0022
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0073	0.0071	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	activated cdc42 kinase 1	0.005	0.0024	0.0022
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0024	0.0022
Loa Loa (eye worm)	TK/ABL protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	vav2	0.0073	0.0071	0.0058
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0092	0.0111	1
Schistosoma mansoni	goodpasture antigen-binding protein	0.0073	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Echinococcus granulosus	calcium dependent secretion activator 1	0.0073	0.0071	0.0078
Trichomonas vaginalis	centaurin/arf, putative	0.0073	0.0071	0.0457
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0073	0.0071	0.0078
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0071	0.5384
Brugia malayi	Plexin repeat family protein	0.0806	0.158	0.1575
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Oxysterol binding protein	0.0073	0.0071	0.0066
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.005	0.0024	0.0019
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0073	0.0071	0.0078
Schistosoma mansoni	vesicular amine transporter	0.0083	0.0091	0.0078
Echinococcus granulosus	oxysterol binding protein 1	0.0073	0.0071	0.0078
Schistosoma mansoni	oxysterol-binding protein 1	0.0073	0.0071	0.0058
Trichomonas vaginalis	STE family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0024	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0024	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	serine/threonine-protein kinase	0.0092	0.0111	0.0098
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/DDR protein kinase	0.005	0.0024	0.0019
Toxoplasma gondii	hypothetical protein	0.0073	0.0071	0.5384
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0092	0.0111	0.0716
Brugia malayi	Oxysterol-binding protein	0.0073	0.0071	0.0066
Brugia malayi	TBC domain containing protein	0.0073	0.0071	0.0066
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Schistosoma mansoni	plexin	0.0806	0.158	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	neuroglian	0.008	0.0086	0.0096
Brugia malayi	Immunoglobulin I-set domain containing protein	0.005	0.0024	0.0019
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus granulosus	neuroglian	0.008	0.0086	0.0096
Trichomonas vaginalis	centaurin alpha, putative	0.0073	0.0071	0.0457
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0092	0.0111	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.008	0.0086	0.0072
Echinococcus granulosus	twitchin	0.0099	0.0126	0.0144
Echinococcus granulosus	axis inhibition protein axin	0.0794	0.1555	0.1854
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0085	0.0096	0.0091
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0096	0.0091
Onchocerca volvulus		0.0073	0.0071	0.0302
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0092	0.0111	0.0716
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Entamoeba histolytica	hypothetical protein	0.0092	0.0111	0.057
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0463	0.0875	0.087
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.0304	0.0548	0.0543
Brugia malayi	ephrin receptor 1 precursor	0.005	0.0024	0.0019
Brugia malayi	serine/threonine protein kinase 6	0.0079	0.0085	0.0079
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.005	0.0024	0.0022
Echinococcus granulosus	activin receptor type	0.007	0.0064	0.007
Echinococcus granulosus	exocyst complex component 2	0.015	0.023	0.0268
Echinococcus granulosus	tyrosine protein kinase pr2	0.005	0.0024	0.0022
Entamoeba histolytica	hypothetical protein, conserved	0.0073	0.0071	0.0307
Echinococcus multilocularis	tyrosine protein kinase shark	0.005	0.0024	0.0022
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.005	0.0024	0.0022
Echinococcus granulosus	tyrosine protein kinase Blk	0.005	0.0024	0.0022
Brugia malayi	DNA-binding protein LAG-1	0.015	0.023	0.0224
Onchocerca volvulus		0.0073	0.0071	0.0302
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.005	0.0024	0.0022
Entamoeba histolytica	hypothetical protein	0.0073	0.0071	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0794	0.1555	0.1551
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	hypothetical protein	0.0463	0.0875	0.0863
Echinococcus multilocularis	regulator of G protein signaling 3	0.0794	0.1555	0.1854
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Schistosoma mansoni	serine/threonine protein kinase	0.3752	0.7647	0.7644
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0079	0.0085	0.0395
Echinococcus granulosus	regulator of G protein signaling 7	0.0794	0.1555	0.1854
Echinococcus granulosus	c src tyrosine kinase	0.005	0.0024	0.0022
Loa Loa (eye worm)	rho-GTPase-activating	0.0073	0.0071	0.0066
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0024	0.0019
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Loa Loa (eye worm)	AUR protein kinase	0.0079	0.0085	0.0079
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Echinococcus granulosus	oxysterol binding protein 3	0.0073	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Brugia malayi	Sema domain containing protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	protein tyrosine kinase, putative	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	plexin	0.0463	0.0875	0.0863
Schistosoma mansoni	axis inhibition protein axin	0.0794	0.1555	0.1544
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Leishmania major	protein kinase, putative	0.0092	0.0111	1
Entamoeba histolytica	hypothetical protein	0.0073	0.0071	0.0307
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Trichomonas vaginalis	conserved hypothetical protein	0.0794	0.1555	1
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	conserved hypothetical protein	0.0794	0.1555	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0024	0.0011
Brugia malayi	SRC-1	0.005	0.0024	0.0019
Brugia malayi	probable spectrin beta chain	0.0073	0.0071	0.0066
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.007	0.0064	0.4616
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0111	0.057
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	protein kinase	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Echinococcus granulosus	Oxysterol binding protein 11	0.0073	0.0071	0.0078
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Echinococcus granulosus	tyrosine protein kinase Lyn	0.007	0.0064	0.007
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Schistosoma mansoni	serine/threonine-protein kinase	0.0092	0.0111	0.0098
Plasmodium vivax	PH domain containing protein	0.0073	0.0071	0.5384
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0071	0.0307
Entamoeba histolytica	protein kinase, putative	0.0079	0.0085	0.0395
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Echinococcus granulosus	myotubularin protein 13	0.0073	0.0071	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0794	0.1555	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4101	0.8366	0.8365
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0073	0.0071	0.0058
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0073	0.0071	0.0078
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	nephrin	0.0085	0.0096	0.0083
Brugia malayi	integrin-linked kinase	0.005	0.0024	0.0019
Echinococcus multilocularis	myotubularin protein 13	0.0073	0.0071	0.0078
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Brugia malayi	Pleckstrin Homology Domain	0.0073	0.0071	0.0066
Echinococcus multilocularis	Pleckstrin y	0.0073	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus granulosus	epidermal growth factor receptor	0.005	0.0024	0.0022
Plasmodium falciparum	PH domain-containing protein, putative	0.0073	0.0071	0.5384
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2959	0.6013	0.7185
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Brugia malayi	Tyrosine-protein kinase PR2	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.013	0.0189	0.0183
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Plasmodium falciparum	protein kinase, putative	0.007	0.0064	0.4616
Echinococcus multilocularis	natriuretic peptide receptor 1	0.005	0.0024	0.0022
Echinococcus granulosus	receptor type guanylyl cyclase	0.005	0.0024	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Echinococcus granulosus	axis inhibition protein axin	0.0794	0.1555	0.1854
Brugia malayi	Raf kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Entamoeba histolytica	hypothetical protein	0.015	0.023	0.1344
Loa Loa (eye worm)	hypothetical protein	0.0806	0.158	0.1575
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0073	0.0071	0.0066
Echinococcus granulosus	regulator of G protein signaling 3	0.0794	0.1555	0.1854
Onchocerca volvulus		0.0342	0.0626	0.3868
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0073	0.0071	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0794	0.1555	0.1551
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0073	0.0071	0.5384
Trichomonas vaginalis	centaurin beta, putative	0.0073	0.0071	0.0457
Echinococcus granulosus	natriuretic peptide receptor 1	0.005	0.0024	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.007	0.0064	0.4616
Schistosoma mansoni	rho gtpase activating protein	0.0073	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4101	0.8366	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Trypanosoma cruzi	NIMA-related kinase, putative	0.0092	0.0111	1
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0073	0.0071	0.5384
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4101	0.8366	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.0024	0.0011
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.015	0.023	0.1478
Echinococcus granulosus	protein tyrosine kinase	0.005	0.0024	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Schistosoma mansoni	centaurin alpha	0.0073	0.0071	0.0058
Echinococcus multilocularis	integrin linked protein kinase	0.005	0.0024	0.0022
Echinococcus granulosus	tyrosine protein kinase	0.005	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Brugia malayi	regulator of G-protein signaling egl-10	0.0794	0.1555	0.1551
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Brugia malayi	PH domain containing protein	0.0073	0.0071	0.0066
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	protein kinase atn1, putative	0.005	0.0024	0.0155
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Echinococcus granulosus	GRB2 associated binding protein 3	0.0073	0.0071	0.0078
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.005	0.0024	0.0022
Echinococcus multilocularis	regulator of G protein signaling 3	0.0794	0.1555	0.1854
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0073	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus granulosus	Pleckstrin y	0.0073	0.0071	0.0078
Schistosoma mansoni	zinc finger protein	0.0073	0.0071	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	epidermal growth factor receptor	0.005	0.0024	0.0022
Echinococcus multilocularis	tyrosine kinase	0.005	0.0024	0.0022
Echinococcus multilocularis	Pleckstrin y	0.0073	0.0071	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.005	0.0024	0.0022
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0794	0.1555	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0794	0.1555	0.1551
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Echinococcus granulosus	aurora kinase A	0.0079	0.0085	0.0095
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0092	0.0111	1
Echinococcus multilocularis	Oxysterol binding protein 11	0.0073	0.0071	0.0078
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Loa Loa (eye worm)	sema domain-containing protein	0.0342	0.0626	0.0621
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0071	0.0066
Schistosoma mansoni	hypothetical protein	0.0073	0.0071	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Entamoeba histolytica	p21-activated kinase	0.0092	0.0111	0.057
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus multilocularis	roundabout 2	0.0085	0.0096	0.0108
Schistosoma mansoni	protein tyrosine kinase	0.005	0.0024	0.0011
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0111	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0073	0.0071	0.0457
Echinococcus multilocularis	tyrosine protein kinase Srms	0.005	0.0024	0.0022
Loa Loa (eye worm)	plexin A	0.0956	0.1889	0.1884
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	activin receptor type	0.007	0.0064	0.007
Echinococcus granulosus	Rho GTPase activating protein 24	0.0073	0.0071	0.0078
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.005	0.0024	0.0022
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Leishmania major	protein kinase, putative	0.0092	0.0111	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0073	0.0071	0.5384
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0073	0.0071	0.0078
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.0024	0.0019
Echinococcus multilocularis	tyrosine protein kinase	0.005	0.0024	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Schistosoma mansoni	protein kinase	0.007	0.0064	0.0051
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0073	0.0071	0.0078
Echinococcus multilocularis	tyrosine protein kinase HCK	0.005	0.0024	0.0022
Echinococcus multilocularis	oxysterol binding protein 1	0.0073	0.0071	0.0078
Echinococcus multilocularis	regulator of G protein signaling	0.0794	0.1555	0.1854
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	TK/FAK protein kinase	0.005	0.0024	0.0019
Echinococcus granulosus	regulator of G protein signaling 7	0.0794	0.1555	0.1854
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	oxysterol binding protein 9	0.0073	0.0071	0.0078
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0073	0.0071	0.0078
Brugia malayi	plexin A	0.0956	0.1889	0.1884
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.005	0.0024	0.0022
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0794	0.1555	0.1551
Loa Loa (eye worm)	AUR protein kinase	0.0079	0.0085	0.0079
Loa Loa (eye worm)	hypothetical protein	0.015	0.023	0.0224
Echinococcus granulosus	plexin a4	0.0956	0.1889	0.2252
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0071	0.5384
Echinococcus multilocularis	aurora kinase A	0.0079	0.0085	0.0095
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Echinococcus multilocularis	epidermal growth factor receptor	0.005	0.0024	0.0022
Loa Loa (eye worm)	PH domain-containing protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Entamoeba histolytica	hypothetical protein	0.015	0.023	0.1344
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Echinococcus granulosus	semaphorin 1A	0.0342	0.0626	0.0742
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0073	0.0071	0.0058
Echinococcus granulosus	Pleckstrin y	0.0073	0.0071	0.0078
Echinococcus multilocularis	axis inhibition protein axin	0.0794	0.1555	0.1854
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.005	0.0024	0.0022
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4895	1	1
Loa Loa (eye worm)	cytohesin 3	0.0073	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Schistosoma mansoni	axis inhibition protein axin	0.0794	0.1555	0.1544
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0085	0.0544
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Trypanosoma brucei	aurora B kinase	0.0079	0.0085	0.6933
Schistosoma mansoni	protein kinase	0.007	0.0064	0.0051
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Echinococcus multilocularis	transfer RNA-Thr	0.005	0.0024	0.0022
Schistosoma mansoni	zinc finger protein	0.0073	0.0071	0.0058
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2959	0.6013	0.7185
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0096	0.0091
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0092	0.0111	1
Loa Loa (eye worm)	oxysterol binding protein	0.0073	0.0071	0.0066
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Echinococcus granulosus	tyrosine kinase	0.005	0.0024	0.0022
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Brugia malayi	Cadps2 protein	0.0073	0.0071	0.0066
Echinococcus granulosus	DCC interacting protein 13 beta	0.0073	0.0071	0.0078
Echinococcus multilocularis	insulin receptor	0.005	0.0024	0.0022
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0092	0.0111	1
Toxoplasma gondii	Oxysterol-binding protein	0.0073	0.0071	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	TK/RYK protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Loa Loa (eye worm)	PXA domain-containing protein	0.0794	0.1555	0.1551
Schistosoma mansoni	z-protein (S1r protein)	0.0794	0.1555	0.1544
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0071	0.0066
Echinococcus granulosus	transcription factor collier	0.015	0.023	0.0268
Brugia malayi	hypothetical protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0626	0.0621
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.015	0.023	0.1478
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Trypanosoma brucei	PH domain containing protein, putative	0.0073	0.0071	0.5384
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	tyrosine kinase	0.005	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	regulator of G protein signaling 7	0.0794	0.1555	0.1854
Echinococcus multilocularis	protein KINase family member (kin 25)	0.005	0.0024	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0024	0.0155
Echinococcus multilocularis	beta 1 syntrophin	0.0073	0.0071	0.0078
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0073	0.0071	0.0078
Toxoplasma gondii	protein kinase domain-containing protein	0.0092	0.0111	1
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0019
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0073	0.0071	0.5384
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Schistosoma mansoni	protein kinase	0.007	0.0064	0.0051
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0111	0.0106
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.007	0.0064	0.007
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0071	0.5384
Schistosoma mansoni	tyrosine protein kinase	0.005	0.0024	0.0011
Echinococcus granulosus	tyrosine protein kinase HCK	0.005	0.0024	0.0022
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Leishmania major	protein kinase, putative	0.007	0.0064	0.4616
Loa Loa (eye worm)	protein kinase domain-containing protein	0.005	0.0024	0.0019
Loa Loa (eye worm)	uncoordinated protein 104	0.0073	0.0071	0.0066
Echinococcus granulosus	raf serine:threonine protein kinase	0.005	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Brugia malayi	Tyrosine-protein kinase abl-1	0.005	0.0024	0.0019
Echinococcus multilocularis	dynamin 1	0.0073	0.0071	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0079	0.0085	0.0395
Brugia malayi	serine/threonine-protein kinase 6	0.0079	0.0085	0.0079
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0073	0.0071	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0024	0.0155
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0073	0.0071	0.0078
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Schistosoma mansoni	ephrin receptor	0.005	0.0024	0.0011
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0092	0.0111	1
Trypanosoma cruzi	hypothetical protein	0.0073	0.0071	0.5384
Loa Loa (eye worm)	hypothetical protein	0.008	0.0086	0.008
Entamoeba histolytica	protein kinase domain containing protein	0.0079	0.0085	0.0395
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Brugia malayi	hypothetical protein	0.005	0.0024	0.0019
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0092	0.0111	1
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.023	0.1478
Echinococcus multilocularis	activated cdc42 kinase 1	0.005	0.0024	0.0022
Schistosoma mansoni	dynamin	0.0073	0.0071	0.0058
Schistosoma mansoni	protein kinase	0.005	0.0024	0.0011
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0071	0.5384
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0024	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0794	0.1555	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0024	0.0022
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Echinococcus granulosus	fibroblast growth factor receptor 4	0.005	0.0024	0.0022
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0085	0.0544
Echinococcus granulosus	kinase suppressor of Ras 1	0.005	0.0024	0.0022
Leishmania major	serine/threonine-protein kinase a, putative	0.0092	0.0111	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.005	0.0024	0.0022
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3752	0.7647	0.914
Echinococcus multilocularis	ephrin type A receptor 4 A	0.005	0.0024	0.0022
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.005	0.0024	0.0019
Loa Loa (eye worm)	TK/EGFR protein kinase	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Schistosoma mansoni	regulator of G protein signaling	0.0794	0.1555	0.1544
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0071	0.0307
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Echinococcus granulosus	Pleckstrin y	0.0073	0.0071	0.0078
Echinococcus granulosus	regulator of G protein signaling 3	0.0794	0.1555	0.1854
Brugia malayi	Protein kinase domain containing protein	0.005	0.0024	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.4895	1	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	protein transport protein sec7, putative	0.0073	0.0071	0.0457
Entamoeba histolytica	PH domain containing protein	0.0073	0.0071	0.0307
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.005	0.0024	0.0022
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0073	0.0071	0.0078
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.0096	0.0091
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0024	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Leishmania major	hypothetical protein, conserved	0.0073	0.0071	0.5384
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0794	0.1555	0.1544
Brugia malayi	bone morphogenetic protein type 1 receptor	0.005	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.015	0.023	0.0224
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.005	0.0024	0.0022
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.005	0.0024	0.0011
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.0085	0.0071
Trypanosoma cruzi	aurora B kinase, putative	0.0079	0.0085	0.6933
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	TK protein kinase	0.005	0.0024	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0794	0.1555	1
Echinococcus multilocularis	plexin a4	0.0956	0.1889	0.2252
Schistosoma mansoni	serine/threonine protein kinase	0.3752	0.7647	0.7644
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0024	0.0019
Brugia malayi	hypothetical protein	0.0342	0.0626	0.0621
Brugia malayi	Receptor family ligand binding region containing protein	0.005	0.0024	0.0019
Schistosoma mansoni	semaphorin 5-related	0.0342	0.0626	0.0613
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Schistosoma mansoni	hypothetical protein	0.0073	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Echinococcus multilocularis	transcription factor collier	0.015	0.023	0.0268
Trichomonas vaginalis	protein transport protein sec7, putative	0.0073	0.0071	0.0457
Entamoeba histolytica	tyrosin kinase, putative	0.02	0.0333	0.2016
Echinococcus multilocularis	axis inhibition protein axin	0.0794	0.1555	0.1854
Onchocerca volvulus		0.0073	0.0071	0.0302
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0073	0.0071	0.5384
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0111	0.057
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	RGS-3 protein	0.0794	0.1555	0.1551
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0071	0.0457
Echinococcus multilocularis	rac serine:threonine kinase	0.0092	0.0111	0.0127
Echinococcus multilocularis	Immunoglobulin	0.008	0.0086	0.0096
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.005	0.0024	0.0019
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.005	0.0024	0.0022
Entamoeba histolytica	hypothetical protein	0.015	0.023	0.1344
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Trypanosoma brucei	protein kinase, putative	0.007	0.0064	0.4616
Entamoeba histolytica	hypothetical protein	0.015	0.023	0.1344
Schistosoma mansoni	hypothetical protein	0.0073	0.0071	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0024	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.008	0.0086	0.008
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0111	0.0716
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.008	0.0086	0.0096
Echinococcus granulosus	tyrosine protein kinase Src42A	0.005	0.0024	0.0022
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0111	1
Echinococcus multilocularis	heat shock protein 70	0.005	0.0024	0.0022
Schistosoma mansoni	regulator of G protein signaling	0.0794	0.1555	0.1544
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0024	0.0022
Onchocerca volvulus		0.0073	0.0071	0.0302
Entamoeba histolytica	protein kinase, putative	0.0092	0.0111	0.057
Entamoeba histolytica	hypothetical protein	0.0794	0.1555	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.005	0.0024	0.0022
Schistosoma mansoni	regulator of G protein signaling	0.0794	0.1555	0.1544

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 0.0001 M	Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomes	ChEMBL.	4038746
IC50 (binding)	> 0.0001 M	Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomes	ChEMBL.	4038746

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 6450501

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 163585