Detailed information for compound 166361

Basic information

Technical information
  • TDR Targets ID: 166361
  • Name: N-[4-[5-chloro-3-(trifluoromethyl)pyrazol-1-y l]phenyl]-3-fluoropyridine-4-carboxamide
  • MW: 384.715 | Formula: C16H9ClF4N4O
  • H donors: 1 H acceptors: 3 LogP: 3.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccncc1F)Nc1ccc(cc1)n1nc(cc1Cl)C(F)(F)F
  • InChi: 1S/C16H9ClF4N4O/c17-14-7-13(16(19,20)21)24-25(14)10-3-1-9(2-4-10)23-15(26)11-5-6-22-8-12(11)18/h1-8H,(H,23,26)
  • InChiKey: VDSUIIKXKKAURC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoro-pyridine-4-carboxamide
  • N-[4-[5-chloro-3-(trifluoromethyl)-1-pyrazolyl]phenyl]-3-fluoro-4-pyridinecarboxamide
  • N-[4-[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoro-isonicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0085 0.0361 0.1256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0091 0.0393 0.0938
Plasmodium vivax unspecified product 0.0054 0.0196 0.1589
Echinococcus granulosus cathepsin L 0.0128 0.0588 0.1423
Brugia malayi cathepsin Z-like cysteine proteinase 0.0054 0.0196 0.0355
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0025 0.0045
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.032 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Schistosoma mansoni inositol monophosphatase 0.0043 0.0137 0.0338
Loa Loa (eye worm) hypothetical protein 0.1047 0.552 1
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0025 0.0025
Mycobacterium tuberculosis Conserved protein 0.0085 0.0361 0.1256
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0025 0.001
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0054 0.0196 0.0485
Brugia malayi Ets-domain containing protein 0.0086 0.0366 0.0664
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0155 0.154
Echinococcus multilocularis PHD finger protein rhinoceros 0.0096 0.0417 0.0403
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0196 0.1986
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.051 0.4312
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0196 0.0697
Brugia malayi cathepsin L-like precursor 0.0162 0.0771 0.1397
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0092 0.0683
Plasmodium vivax vivapain-2 0.0235 0.1163 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0073 0.0296 0.0536
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0296 0.0514
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.077 0.1875
Giardia lamblia PHD finger protein 15 0.0096 0.0417 0.4419
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0085 0.0361 0.1256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0025 0.001
Onchocerca volvulus Cathepsin F homolog 0.0235 0.1163 0.2107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0091 0.0393 0.0378
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.1163 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0288 0.1449 0.2625
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0137 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0196 0.0485
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0054 0.0196 0.0485
Brugia malayi Cathepsin L-like cysteine proteinase 0.0162 0.0771 0.1397
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0164 0.0149
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0025 0.0062
Brugia malayi Inositol-1 0.0043 0.0137 0.0247
Brugia malayi Cathepsin L-like precursor 0.0162 0.0771 0.1397
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0332
Brugia malayi mbt repeat family protein 0.0112 0.0505 0.0914
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0025 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0494 0.2555 0.6321
Toxoplasma gondii ABC1 family protein 0.0085 0.0361 0.301
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0025 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0025 0.0025
Loa Loa (eye worm) ctsf protein 0.0235 0.1163 0.2088
Brugia malayi Pre-SET motif family protein 0.0069 0.0275 0.0499
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0064 0.0249 0.2035
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0054 0.0196 0.0697
Giardia lamblia Cathepsin L precursor 0.0054 0.0196 0.1986
Onchocerca volvulus 0.0085 0.0361 0.0653
Loa Loa (eye worm) hypothetical protein 0.0182 0.0883 0.1579
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Schistosoma mansoni hypothetical protein 0.0085 0.036 0.0891
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.032 0.1199
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.032 0.2652
Brugia malayi PHD-finger family protein 0.0096 0.0417 0.0756
Schistosoma mansoni jumonji/arid domain-containing protein 0.0199 0.0971 0.2402
Echinococcus granulosus lamin 0.0032 0.0074 0.0146
Onchocerca volvulus 0.0085 0.0361 0.0653
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.0588 0.499
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0229 0.0392
Schistosoma mansoni cpg binding protein 0.0075 0.0304 0.0753
Echinococcus multilocularis beta LACTamase domain containing family member 0.0085 0.0361 0.0346
Brugia malayi Pre-SET motif family protein 0.0475 0.245 0.4438
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.005 0.1062
Entamoeba histolytica cysteine protease, putative 0.0054 0.0196 0.1575
Loa Loa (eye worm) hypothetical protein 0.0245 0.1217 0.2185
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0025 0.0045
Giardia lamblia Cathepsin B precursor 0.0054 0.0196 0.1986
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0296 0.1107
Loa Loa (eye worm) hypothetical protein 0.0144 0.0675 0.1202
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0025 0.0062
Echinococcus granulosus beta LACTamase domain containing family member 0.0085 0.0361 0.0858
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0166 0.0411
Brugia malayi AMP-binding enzyme family protein 0.0027 0.005 0.0091
Entamoeba histolytica hypothetical protein 0.0042 0.0131 0.1005
Echinococcus granulosus lysine specific demethylase 5A 0.0199 0.0971 0.2374
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0475 0.245 0.4425
Brugia malayi hypothetical protein 0.0144 0.0675 0.1223
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0208 0.0376
Echinococcus multilocularis musashi 0.0032 0.0074 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0025 0.0062
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0494 0.2555 0.6321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0606 0.15
Onchocerca volvulus 0.0235 0.1163 0.2107
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0339 0.1725 0.1712
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0137 0.0122
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0519 0.1285
Echinococcus granulosus histone lysine methyltransferase setb 0.0164 0.0784 0.1908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Brugia malayi cathepsin B-like cysteine proteinase 0.0494 0.2555 0.4628
Echinococcus granulosus GPCR family 2 0.0091 0.0393 0.0938
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0204 0.1644
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0275 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Schistosoma mansoni methyl-cpg binding protein mbd 0.0095 0.0412 0.102
Loa Loa (eye worm) hypothetical protein 0.0031 0.0071 0.0105
Onchocerca volvulus 0.0027 0.005 0.0091
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0054 0.0196 0.1589
Echinococcus multilocularis geminin 0.0771 0.4042 0.4033
Brugia malayi cathepsin Z-like cysteine proteinase 0.0054 0.0196 0.0355
Onchocerca volvulus 0.0032 0.0074 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0091 0.0393 0.0938
Schistosoma mansoni methyl-cpg binding protein mbd 0.0095 0.0412 0.102
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0137 0.1058
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0332
Echinococcus granulosus cathepsin l1 0.0162 0.0771 0.1877
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0204 0.0189
Brugia malayi Cathepsin L-like precursor 0.0235 0.1163 0.2107
Echinococcus granulosus histone acetyltransferase KAT2B 0.0064 0.0249 0.058
Loa Loa (eye worm) hypothetical protein 0.0197 0.096 0.172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0025 0.0022
Toxoplasma gondii preprocathepsin c precursor, putative 0.0054 0.0196 0.1575
Giardia lamblia Cathepsin B precursor 0.019 0.0925 1
Echinococcus multilocularis zinc finger protein 0.0116 0.0529 0.0515
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0054 0.0196 0.1589
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0339 0.1725 0.4246
Plasmodium falciparum phd finger protein, putative 0.0096 0.0417 0.3516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0196 0.0697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0025 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0164 0.0583
Brugia malayi CXXC zinc finger family protein 0.0061 0.0229 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0025 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0025 0.0062
Plasmodium vivax vivapain-1 0.0128 0.0588 0.4999
Loa Loa (eye worm) hypothetical protein 0.0393 0.2012 0.363
Loa Loa (eye worm) hypothetical protein 0.0085 0.0361 0.0631
Echinococcus granulosus cpg binding protein 0.0075 0.0304 0.0718
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0137 0.0302
Plasmodium vivax vivapain-3 0.0128 0.0588 0.4999
Echinococcus multilocularis protein dispatched 1 0.0055 0.0201 0.0186
Brugia malayi PHD-finger family protein 0.0146 0.0688 0.1246
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.005 0.1062
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0445 0.2293 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0235 0.1163 0.4151
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.032 0.0556
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.005 0.0152
Loa Loa (eye worm) hypothetical protein 0.016 0.0761 0.1358
Brugia malayi nuclear receptor NHR-88 0.0023 0.0025 0.0045
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Brugia malayi latrophilin 2 splice variant baaae 0.0197 0.096 0.174
Echinococcus granulosus cathepsin L cysteine protease 0.0128 0.0588 0.1423
Trypanosoma brucei ISWI complex protein 0.0085 0.036 0.3005
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.0361 0.1285
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0054 0.0196 0.0485
Loa Loa (eye worm) hypothetical protein 0.0085 0.0361 0.0631
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0196 0.0332
Schistosoma mansoni patched 1 0.0048 0.0164 0.0406
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0056 0.0204 0.1644
Echinococcus granulosus JmjC domain containing protein 4 0.0049 0.0168 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Onchocerca volvulus Cathepsin L homolog 0.0235 0.1163 0.2107
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0128 0.0588 0.1455
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0155 0.1221
Loa Loa (eye worm) hypothetical protein 0.0162 0.0771 0.1376
Brugia malayi Cathepsin L-like precursor 0.0235 0.1163 0.2107
Echinococcus granulosus expressed conserved protein 0.0106 0.0473 0.1138
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1163 0.452
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0025 0.0045
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0056 0.0204 0.0699
Schistosoma mansoni hypothetical protein 0.0047 0.0155 0.0383
Schistosoma mansoni cpg binding protein 0.0075 0.0304 0.0753
Trichomonas vaginalis bromodomain-containing protein, putative 0.0064 0.0249 0.0886
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.1163 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0031 0.0072 0.0494
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0015 0.0017
Brugia malayi Bromodomain containing protein 0.0424 0.2181 0.3951
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0025 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0235 0.1163 0.115
Echinococcus granulosus cathepsin l1 0.0235 0.1163 0.2851
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0025 0.0062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.02 0.0975 0.2384
Schistosoma mansoni hypothetical protein 0.0047 0.0155 0.0383
Plasmodium falciparum serine repeat antigen 2 0.0054 0.0196 0.1589
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0187 0.0907 0.2243
Brugia malayi jmjC domain containing protein 0.0049 0.0168 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0025 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0196 0.0485
Echinococcus multilocularis cathepsin L 0.0128 0.0588 0.0574
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0168 0.0604
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Plasmodium falciparum serine repeat antigen 1 0.0054 0.0196 0.1589
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0494 0.2555 0.6321
Giardia lamblia Cathepsin L-like protease 0.0054 0.0196 0.1986
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1163 0.452
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0196 0.0485
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0544 0.2821 1
Onchocerca volvulus 0.0054 0.0196 0.0355
Brugia malayi cathepsin L precursor 0.0054 0.0196 0.0355
Brugia malayi beta-lactamase 0.0085 0.0361 0.0653
Plasmodium falciparum cysteine proteinase falcipain 1 0.0128 0.0588 0.4999
Plasmodium vivax hypothetical protein, conserved 0.0096 0.0417 0.3516
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.051 0.0496
Echinococcus multilocularis cathepsin L cysteine protease 0.0235 0.1163 0.115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0025 0.0045
Brugia malayi Cathepsin L-like precursor 0.0235 0.1163 0.2107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0025 0.0022
Loa Loa (eye worm) cathepsin B 0.019 0.0925 0.1657
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0054 0.0196 0.0355
Giardia lamblia Cathepsin L precursor 0.0054 0.0196 0.1986
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0137 0.1058
Onchocerca volvulus 0.0235 0.1163 0.2107
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0025 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0137 0.1058
Loa Loa (eye worm) PHD-finger family protein 0.0096 0.0417 0.0734
Echinococcus granulosus cathepsin b 0.0494 0.2555 0.6307
Onchocerca volvulus Huntingtin homolog 0.0144 0.0675 0.1223
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Plasmodium vivax SET domain protein, putative 0.0069 0.0275 0.228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0162 0.0771 0.2751
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0025 0.001
Entamoeba histolytica cysteine protease, putative 0.0054 0.0196 0.1575
Brugia malayi Latrophilin receptor protein 2 0.0091 0.0393 0.0712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0056 0.0204 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0235 0.1163 0.4151
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0056 0.0204 0.1659
Brugia malayi isocitrate dehydrogenase 0.0056 0.0204 0.0369
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0137 0.0478
Giardia lamblia Cathepsin L precursor 0.0054 0.0196 0.1986
Giardia lamblia Encystation-specific protease 0.0054 0.0196 0.1986
Schistosoma mansoni lozenge 0.0131 0.0609 0.1506
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Mycobacterium leprae Probable lipase LipE 0.0085 0.0361 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0137 0.0485
Trichomonas vaginalis set domain proteins, putative 0.054 0.2801 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Loa Loa (eye worm) runx1 0.0131 0.0609 0.1081
Loa Loa (eye worm) cysteine protease 0.0235 0.1163 0.2088
Toxoplasma gondii cathepsin CPC1 0.0054 0.0196 0.1575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0025 0.0025
Brugia malayi Fli-1 protein 0.0262 0.1308 0.2369
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0015 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0027 0.005 0.0091
Brugia malayi Isocitrate dehydrogenase 0.0056 0.0204 0.0369
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.032 0.1199
Schistosoma mansoni lamin 0.0032 0.0074 0.0183
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0054 0.0196 0.0697
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.005 0.1062
Leishmania major hypothetical protein, conserved 0.0049 0.0168 0.1336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0025 0.0022
Echinococcus multilocularis cysteine protease 0.0235 0.1163 0.115
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0235 0.1163 0.115
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.0588 0.1065
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0091 0.0393 0.0712
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0244
Loa Loa (eye worm) bromodomain containing protein 0.0102 0.0453 0.08
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0025 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0588 0.499
Schistosoma mansoni lamin 0.0032 0.0074 0.0183
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0054 0.0196 0.1589
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Echinococcus granulosus cathepsin b 0.0494 0.2555 0.6307
Schistosoma mansoni zinc finger protein 0.0085 0.036 0.0891
Leishmania major cysteine peptidase A (CPA) 0.0235 0.1163 1
Brugia malayi Cathepsin L-like precursor 0.0235 0.1163 0.2107
Echinococcus granulosus jumonji domain containing protein 0.0133 0.0618 0.1498
Plasmodium falciparum serine repeat antigen 5 0.0054 0.0196 0.1589
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0025 0.001
Schistosoma mansoni hypothetical protein 0.0197 0.096 0.2376
Loa Loa (eye worm) hypothetical protein 0.0235 0.1163 0.2088
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.019 0.0925 0.3303
Loa Loa (eye worm) MBCTL1 0.0127 0.0588 0.1043
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1163 0.452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Loa Loa (eye worm) fli-1 protein 0.0262 0.1308 0.2351
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0063 0.0244 0.0568
Echinococcus multilocularis cathepsin L 0.0054 0.0196 0.0181
Loa Loa (eye worm) hypothetical protein 0.0144 0.0675 0.1202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0382 0.1955 0.4819
Loa Loa (eye worm) mbt repeat family protein 0.0112 0.0505 0.0892
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0063 0.0244 0.0229
Schistosoma mansoni hypothetical protein 0.0685 0.3577 0.8851
Plasmodium falciparum serine repeat antigen 3 0.0054 0.0196 0.1589
Loa Loa (eye worm) hypothetical protein 0.0073 0.0296 0.0514
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0015 0.0051
Plasmodium falciparum JmjC domain-containing protein, putative 0.0049 0.0168 0.1351
Toxoplasma gondii cathepsin CPL 0.0235 0.1163 1
Brugia malayi jmjC domain containing protein 0.0049 0.0168 0.0305
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0235 0.1163 0.2088
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0164 0.037
Mycobacterium tuberculosis Conserved protein 0.0085 0.0361 0.1256
Plasmodium vivax JmjC domain containing protein 0.0049 0.0168 0.1351
Schistosoma mansoni ap endonuclease 0.0021 0.0015 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0196 0.0697
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0112 0.0373
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0164 0.0784 0.077
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0025 0.0025
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.1141 0.2048
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.051 0.0924
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0296 0.1107
Plasmodium falciparum serine repeat antigen 6 0.0054 0.0196 0.1589
Loa Loa (eye worm) hypothetical protein 0.0113 0.051 0.0902
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0025 0.0045
Trichomonas vaginalis penicillin-binding protein, putative 0.0085 0.0361 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0196 0.0697
Trypanosoma brucei cysteine peptidase C (CPC) 0.019 0.0925 0.793
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0015 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0204 0.1644
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0054 0.0196 0.1589
Brugia malayi Bromodomain containing protein 0.0217 0.1068 0.1935
Onchocerca volvulus 0.0162 0.0771 0.1397
Loa Loa (eye worm) hypothetical protein 0.0049 0.0168 0.0282
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0296 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0196 0.0697
Schistosoma mansoni hypothetical protein 0.0096 0.0417 0.1033
Onchocerca volvulus Huntingtin homolog 0.0144 0.0675 0.1223
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0235 0.1163 0.115
Trypanosoma cruzi cruzipain precursor, putative 0.0235 0.1163 0.452
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0064 0.0249 0.0886
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0196 0.0485
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0196 0.0355
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0085 0.0361 0.1256
Mycobacterium ulcerans hypothetical protein 0.0085 0.0361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.0588 0.2097
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0235 0.1163 0.2088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0275 0.0681
Echinococcus multilocularis SAM and MBT domain containing protein 0.0112 0.0505 0.049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0196 0.1986
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0025 0.0062
Echinococcus granulosus fetal alzheimer antigen falz 0.0129 0.0595 0.1439
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0085 0.0361 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0056 0.0204 0.0189
Echinococcus granulosus dnaJ subfamily B 0.0433 0.2224 0.5486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0164 0.0784 0.1939
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0096 0.0417 0.1033
Brugia malayi cathepsin L-like cysteine proteinase 0.0054 0.0196 0.0355
Entamoeba histolytica hypothetical protein 0.0042 0.0131 0.1005
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Entamoeba histolytica hypothetical protein 0.0054 0.0196 0.1575
Brugia malayi Calcitonin receptor-like protein seb-1 0.0288 0.1449 0.2625
Echinococcus multilocularis JmjC domain containing protein 4 0.0049 0.0168 0.0154
Onchocerca volvulus 0.0235 0.1163 0.2107
Onchocerca volvulus 0.016 0.0761 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0025 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0135 0.0626 0.5324
Brugia malayi Bromodomain containing protein 0.0113 0.0511 0.0925
Schistosoma mansoni cathepsin F (C01 family) 0.0235 0.1163 0.2878
Echinococcus granulosus intermediate filament protein 0.0032 0.0074 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.005 0.0304
Brugia malayi ecdysteroid receptor 0.0023 0.0025 0.0045
Trichomonas vaginalis esterase, putative 0.0085 0.0361 0.1285
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0013 0.5
Echinococcus granulosus GA binding protein alpha chain 0.0086 0.0366 0.0873
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0332
Toxoplasma gondii cathepsin B 0.019 0.0925 0.793
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.005 0.0304
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0056 0.0204 0.0189
Schistosoma mansoni protein phosphatase 2C 0.0049 0.0168 0.0417
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.077 0.0756
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.032 0.2652
Loa Loa (eye worm) hypothetical protein 0.0288 0.1449 0.2608
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0235 0.1163 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0164 0.0784 0.1399
Brugia malayi fibroinase precursor 0.0054 0.0196 0.0355
Brugia malayi cathepsin F-like cysteine proteinase 0.0054 0.0196 0.0355
Echinococcus multilocularis polycomb protein SCMH1 0.0112 0.0505 0.049
Toxoplasma gondii cathepsin CPC2 0.0054 0.0196 0.1575
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1163 0.452
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0054 0.0196 0.1575
Echinococcus granulosus lamin dm0 0.0032 0.0074 0.0146
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0015 0.0028
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0056 0.0204 0.1659
Loa Loa (eye worm) fibroinase 0.0235 0.1163 0.2088
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.005 0.0304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0025 0.0045
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0054 0.0196 0.1575
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0054 0.0196 0.0485
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0049 0.0168 0.1336
Echinococcus granulosus jumonji domain containing 1A 0.0049 0.0168 0.0381
Brugia malayi jmjC domain containing protein 0.0382 0.1955 0.3542
Loa Loa (eye worm) hypothetical protein 0.0059 0.0223 0.038
Brugia malayi nuclear hormone receptor 0.0023 0.0025 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0064 0.0249 0.2049
Schistosoma mansoni hypothetical protein 0.0047 0.0155 0.0383
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0018 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0198 0.0964 0.1727
Brugia malayi Ets-domain containing protein 0.0086 0.0366 0.0664
Trypanosoma cruzi ISWI complex protein 0.0085 0.036 0.1358
Giardia lamblia Cathepsin B precursor 0.0054 0.0196 0.1986
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0196 0.0355
Loa Loa (eye worm) hypothetical protein 0.0049 0.0168 0.0282
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0275 0.2267
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0361 0.3022
Entamoeba histolytica cysteine proteinase 1, putative 0.0128 0.0588 0.499
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.1393 0.138
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0137 0.0478
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0025 0.0062
Echinococcus granulosus peregrin 0.0113 0.0511 0.1231
Loa Loa (eye worm) hypothetical protein 0.0112 0.0505 0.0892
Echinococcus multilocularis cpg binding protein 0.0075 0.0304 0.029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0196 0.0332
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0235 0.1163 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0137 0.0485
Brugia malayi AMP-binding enzyme family protein 0.0027 0.005 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0025 0.0022
Giardia lamblia Cysteine protease 0.0054 0.0196 0.1986
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0067
Plasmodium vivax SET domain containing protein 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0073 0.0296 0.0514
Brugia malayi hypothetical protein 0.016 0.0761 0.1379
Schistosoma mansoni coup transcription factor 0.0023 0.0025 0.0062
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0112 0.2004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0025 0.0025
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Trypanosoma brucei hypothetical protein, conserved 0.0085 0.0361 0.301
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0056 0.0204 0.0469
Echinococcus multilocularis lamin 0.0032 0.0074 0.0059
Onchocerca volvulus 0.0023 0.0025 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.0588 0.2097
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0127 0.0588 0.0574
Onchocerca volvulus Alhambra homolog 0.0096 0.0417 0.0756
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0196 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0025 0.0045
Plasmodium vivax unspecified product 0.0073 0.0296 0.2461
Loa Loa (eye worm) hypothetical protein 0.0085 0.0361 0.0631
Schistosoma mansoni cathepsin S (C01 family) 0.0054 0.0196 0.0485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0164 0.0784 0.1939
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0064 0.0249 0.2035
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0162 0.0771 0.2976
Loa Loa (eye worm) hypothetical protein 0.0127 0.0588 0.1043
Loa Loa (eye worm) jmjC domain-containing protein 0.0199 0.0971 0.1739
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.019 0.0925 0.229
Echinococcus multilocularis GPCR, family 2 0.0091 0.0393 0.0378
Giardia lamblia Cathepsin B precursor 0.019 0.0925 1
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0196 0.0355
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0025 0.0022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.005 0.1062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.0588 0.499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0204 0.0189
Mycobacterium ulcerans hypothetical protein 0.0027 0.005 0.1062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0204 0.0189
Echinococcus granulosus methyl CpG binding domain protein 2 0.0095 0.0412 0.0987
Plasmodium falciparum serine repeat antigen 8 0.0054 0.0196 0.1589
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0025 0.0062
Mycobacterium ulcerans beta-lactamase 0.0085 0.0361 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0494 0.2555 0.6321
Loa Loa (eye worm) latrophilin receptor protein 2 0.0091 0.0393 0.069
Echinococcus multilocularis Protein lozenge 0.0131 0.0609 0.0594
Schistosoma mansoni hypothetical protein 0.0057 0.0208 0.0514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Onchocerca volvulus 0.054 0.2801 0.5074
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0128 0.0588 0.2256
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Echinococcus granulosus zinc finger protein 0.0116 0.0529 0.1276
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0164 0.037
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0054 0.0196 0.1589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0288 0.1449 0.2608
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0025 0.0025
Plasmodium falciparum cysteine proteinase falcipain 3 0.0235 0.1163 1
Schistosoma mansoni cathepsin s 0.0073 0.0296 0.0733
Mycobacterium tuberculosis Probable hydrolase 0.0085 0.0361 0.1256
Giardia lamblia Cathepsin B precursor 0.0054 0.0196 0.1986
Giardia lamblia Cathepsin L precursor 0.0054 0.0196 0.1986
Trypanosoma cruzi ISWI complex protein 0.0085 0.036 0.1358
Trichomonas vaginalis penicillin-binding protein, putative 0.0085 0.0361 0.1285
Echinococcus multilocularis lamin dm0 0.0032 0.0074 0.0059
Plasmodium falciparum serine repeat antigen 7 0.0054 0.0196 0.1589
Brugia malayi Papain family cysteine protease containing protein 0.0235 0.1163 0.2107
Mycobacterium tuberculosis Conserved protein 0.0085 0.0361 0.1256
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Leishmania major hypothetical protein, conserved 0.0085 0.0361 0.301
Schistosoma mansoni cathepsin C 0.0054 0.0196 0.0485
Plasmodium vivax unspecified product 0.0128 0.0588 0.4999
Brugia malayi CHE-14 protein 0.0048 0.0164 0.0297
Echinococcus multilocularis peregrin 0.0113 0.0511 0.0496
Loa Loa (eye worm) hypothetical protein 0.0162 0.0771 0.1376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Plasmodium vivax serine-repeat antigen (SERA) 0.0054 0.0196 0.1589
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0164 0.0274
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0013 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0361 0.136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0056 0.0204 0.0743
Schistosoma mansoni hypothetical protein 0.0047 0.0155 0.0383
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0025 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0131 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0445 0.2293 0.5657
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.1393 0.3421
Entamoeba histolytica cysteine protease, putative 0.0054 0.0196 0.1575
Toxoplasma gondii PHD-finger domain-containing protein 0.0096 0.0417 0.3504
Loa Loa (eye worm) hypothetical protein 0.0085 0.0361 0.0631
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0137 0.3554
Schistosoma mansoni cpg binding protein 0.0061 0.0229 0.0566
Loa Loa (eye worm) hypothetical protein 0.1047 0.552 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0275 0.0261
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0018 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0025 0.0045
Brugia malayi jmjC domain containing protein 0.0199 0.0971 0.1759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Schistosoma mansoni hypothetical protein 0.0042 0.0131 0.0323
Onchocerca volvulus 0.0235 0.1163 0.2107
Schistosoma mansoni hypothetical protein 0.0115 0.0519 0.1284
Schistosoma mansoni hypothetical protein 0.0091 0.0393 0.0972
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0054 0.0196 0.0697
Schistosoma mansoni cathepsin B (C01 family) 0.0054 0.0196 0.0485
Brugia malayi hypothetical protein 0.0278 0.1393 0.2523
Echinococcus granulosus cathepsin L 0.0054 0.0196 0.0449
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0025 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.0162 0.0771 0.1907
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0025 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0168 0.0282
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0025 0.0025
Schistosoma mansoni phd/f-box containing protein 0.0049 0.0168 0.0417
Mycobacterium leprae conserved hypothetical protein 0.0085 0.0361 1
Brugia malayi steroid hormone receptor 0.0023 0.0025 0.0045
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.019 0.0925 0.793
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0332
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.005 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Onchocerca volvulus 0.0032 0.0074 0.0134
Brugia malayi mbt repeat family protein 0.0112 0.0505 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0196 0.0697
Loa Loa (eye worm) isocitrate dehydrogenase 0.0056 0.0204 0.0346
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0025 0.0062
Echinococcus multilocularis GA binding protein alpha chain 0.0086 0.0366 0.0352
Giardia lamblia Hypothetical protein 0.0054 0.0196 0.1986
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0128 0.0588 0.1455
Entamoeba histolytica cysteine protease, putative 0.0054 0.0196 0.1575
Mycobacterium ulcerans lipase LipD 0.0085 0.0361 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0112 0.0505 0.0914
Giardia lamblia Cysteine protease 0.0054 0.0196 0.1986
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.032 0.0791
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0054 0.0196 0.1589
Mycobacterium tuberculosis Probable lipase LipE 0.0085 0.0361 0.1256
Echinococcus granulosus PHD finger protein rhinoceros 0.0096 0.0417 0.0999
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0049 0.0168 0.1336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0196 0.0697
Schistosoma mansoni intermediate filament proteins 0.0032 0.0074 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0196 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0025 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0065 0.0255 0.0595
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0196 0.0355
Onchocerca volvulus 0.0057 0.0208 0.0376
Loa Loa (eye worm) hypothetical protein 0.0096 0.0417 0.0734
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.0361 0.1285
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0145 0.0322
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0025 0.0062
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0204 0.1644
Giardia lamblia Cysteine protease 0.0054 0.0196 0.1986
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0085 0.0361 0.0892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Giardia lamblia Cathepsin L-like protease 0.0054 0.0196 0.1986
Brugia malayi N-terminal motif family protein 0.0191 0.0928 0.1681
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0049 0.0168 0.0417
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.0771 0.6584
Echinococcus multilocularis phd:f box containing protein 0.0049 0.0168 0.0154
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0018 0.0007
Brugia malayi Cathepsin L-like precursor 0.0162 0.0771 0.1397
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0145 0.013
Brugia malayi jmjC domain containing protein 0.0049 0.0168 0.0305
Brugia malayi hypothetical protein 0.0042 0.0131 0.0236
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0095 0.0412 0.0398
Echinococcus multilocularis cathepsin b 0.0494 0.2555 0.2544
Giardia lamblia Cathepsin L precursor 0.0054 0.0196 0.1986
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0031 0.0072 0.0494
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0187 0.0907 0.0893
Entamoeba histolytica cysteine proteinase 2 0.0128 0.0588 0.499
Schistosoma mansoni hypothetical protein 0.0031 0.0072 0.0178
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0025 0.0025
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0054 0.0196 0.1589
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0085 0.0361 0.0892
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0074 0.011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.005 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0025 0.0045
Schistosoma mansoni hypothetical protein 0.0091 0.0393 0.0972
Giardia lamblia Cathepsin B precursor 0.0054 0.0196 0.1986
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0127 0.0588 0.1065
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0054 0.0196 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0196 0.0697
Entamoeba histolytica cysteine protease, putative 0.0235 0.1163 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0015 0.5
Echinococcus granulosus geminin 0.0771 0.4042 1
Trypanosoma cruzi cysteine proteinase, putative 0.0128 0.0588 0.2256
Echinococcus multilocularis lysine specific demethylase 6a 0.0049 0.0168 0.0154
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0112 0.0505 0.1248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Brugia malayi PHD-finger family protein 0.0045 0.0147 0.0267
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0086 0.0366 0.0642
Echinococcus granulosus cathepsin l cysteine peptidase 0.0235 0.1163 0.2851
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.0361 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0131 0.0323
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0168 0.0604
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0085 0.0361 0.0653
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Echinococcus granulosus histone acetyltransferase KAT2B 0.0169 0.081 0.1974
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.005 0.1062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0091 0.0393 0.0378
Loa Loa (eye worm) hypothetical protein 0.0162 0.0771 0.1376
Giardia lamblia Cathepsin B precursor 0.019 0.0925 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Loa Loa (eye worm) inositol-1 0.0043 0.0137 0.0224
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0168 0.0282
Schistosoma mansoni hypothetical protein 0.0771 0.4042 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0299 0.052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0196 0.0485
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0025 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0168 0.0282
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.0928 0.1681
Schistosoma mansoni hypothetical protein 0.0091 0.0393 0.0972
Toxoplasma gondii PHD-finger domain-containing protein 0.0096 0.0417 0.3504
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.032 0.2652
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.005 0.1062
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0072 0.0494
Leishmania major hypothetical protein, conserved 0.0085 0.036 0.3005
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0067
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0204 0.0743
Schistosoma mansoni ets-related 0.0262 0.1308 0.3236
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Echinococcus granulosus cysteine protease 0.0128 0.0588 0.1423
Mycobacterium tuberculosis Probable lipase LipD 0.0085 0.0361 0.1256
Entamoeba histolytica cysteine protease, putative 0.0054 0.0196 0.1575
Plasmodium vivax vivapain-2 0.0235 0.1163 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0015 0.0004
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0049 0.0168 0.1336
Echinococcus granulosus phd:f box containing protein 0.0049 0.0168 0.0381
Schistosoma mansoni sex comb on midleg homolog 0.0112 0.0505 0.1248
Schistosoma mansoni hypothetical protein 0.0771 0.4042 1
Onchocerca volvulus 0.0085 0.0361 0.0653
Loa Loa (eye worm) beta-lactamase 0.0085 0.0361 0.0631
Schistosoma mansoni cathepsin F (C01 family) 0.0235 0.1163 0.2878
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0137 0.0485
Schistosoma mansoni hypothetical protein 0.0091 0.0393 0.0972
Echinococcus multilocularis jumonji domain containing 1A 0.0049 0.0168 0.0154
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.02 0.0975 0.0961
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0155 0.1237
Schistosoma mansoni hypothetical protein 0.0433 0.2224 0.5503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0025 0.0022
Brugia malayi Cathepsin L-like precursor 0.0073 0.0296 0.0536
Giardia lamblia Cysteine protease 0.0054 0.0196 0.1986
Echinococcus multilocularis protein patched 0.0048 0.0164 0.0149
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0196 0.1986
Loa Loa (eye worm) hypothetical protein 0.0091 0.0393 0.069
Onchocerca volvulus 0.0061 0.0229 0.0415
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.019 0.0925 0.3584
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0054 0.0196 0.1589
Echinococcus multilocularis cathepsin b 0.0494 0.2555 0.2544
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0204 0.1644
Schistosoma mansoni sex comb on midleg homolog 0.0112 0.0505 0.1248
Echinococcus multilocularis lysine specific demethylase 5A 0.0185 0.0896 0.0882
Trypanosoma cruzi cysteine protease, putative 0.0128 0.0588 0.2256
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0025 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.051 0.1229
Loa Loa (eye worm) hypothetical protein 0.0085 0.0361 0.0631
Brugia malayi F/Y-rich N-terminus family protein 0.0063 0.0241 0.0437
Echinococcus multilocularis jumonji domain containing protein 0.0133 0.0618 0.0604
Onchocerca volvulus 0.0112 0.0505 0.0914
Plasmodium falciparum serine repeat antigen 4 0.0054 0.0196 0.1589
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.0588 0.499
Brugia malayi acetyltransferase, GNAT family protein 0.0187 0.0907 0.1642
Onchocerca volvulus 0.0235 0.1163 0.2107
Brugia malayi beta-lactamase family protein 0.0085 0.0361 0.0653
Giardia lamblia Cathepsin B precursor 0.0054 0.0196 0.1986
Schistosoma mansoni jumonji/arid domain-containing protein 0.0199 0.0971 0.2402
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0054 0.0196 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0196 0.0697
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.005 0.0152
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0074 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Echinococcus granulosus SAM and MBT domain containing protein 0.0112 0.0505 0.1216
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0085 0.0361 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.0588 0.1065
Giardia lamblia Cathepsin L precursor 0.0054 0.0196 0.1986
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0025 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0196 0.0697
Schistosoma mansoni bromodomain containing protein 0.0359 0.1832 0.4531
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0025 0.0045
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0196 0.0712
Schistosoma mansoni zinc finger protein 0.0116 0.0529 0.1309
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.0588 0.499
Echinococcus granulosus lysine specific demethylase 6a 0.0049 0.0168 0.0381
Brugia malayi hypothetical protein 0.1047 0.552 1
Plasmodium falciparum serine repeat antigen 9 0.0054 0.0196 0.1589
Onchocerca volvulus 0.1047 0.552 1
Schistosoma mansoni gabp alpha 0.0086 0.0366 0.0907
Echinococcus granulosus polycomb protein SCMH1 0.0112 0.0505 0.1216
Schistosoma mansoni phosphatidylserine receptor 0.0049 0.0168 0.0417
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0137 0.1058
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0588 0.2256
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0054 0.0196 0.1589
Loa Loa (eye worm) acetyltransferase 0.0187 0.0907 0.1623
Onchocerca volvulus 0.0069 0.0275 0.0499
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0035 0.0092 0.0683
Brugia malayi AF-10 protein 0.0031 0.0072 0.013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0131 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0196 0.0697
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.032 0.0305
Trypanosoma cruzi cysteine proteinase, putative 0.0128 0.0588 0.2256
Loa Loa (eye worm) hypothetical protein 0.0213 0.1048 0.1879
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0361 0.136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0022
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0588 0.499
Echinococcus granulosus cathepsin L cysteine proteinase 0.0235 0.1163 0.2851
Giardia lamblia Hypothetical protein 0.0054 0.0196 0.1986
Loa Loa (eye worm) hypothetical protein 0.0494 0.2555 0.4615
Schistosoma mansoni inositol monophosphatase 0.0043 0.0137 0.0338
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.011
Brugia malayi jmjC domain containing protein 0.0049 0.0168 0.0305
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0031 0.0072 0.0494
Entamoeba histolytica hypothetical protein 0.0042 0.0131 0.1005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1163 0.4151
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0196 0.0712
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.2224 0.2213
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0054 0.0196 0.0332
Brugia malayi beta-lactamase family protein 0.0085 0.0361 0.0653
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0015 0.0027
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0196 0.0697
Onchocerca volvulus Cathepsin L homolog 0.0235 0.1163 0.2107
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.032 0.0756
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0015 0.0051
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0054 0.0196 0.1986
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0025 0.0045
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0054 0.0196 0.1589
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0054 0.0196 0.1589
Mycobacterium tuberculosis Probable esterase LipL 0.0085 0.0361 0.1256
Schistosoma mansoni myelin transcription factor 1 myt1 0.0127 0.0588 0.1454
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0129 0.0595 0.1471
Loa Loa (eye worm) PHD-finger family protein 0.0115 0.0519 0.0919
Mycobacterium ulcerans esterase/lipase LipP 0.0085 0.0361 1
Echinococcus multilocularis expressed conserved protein 0.0106 0.0473 0.0459
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0054 0.0196 0.1589
Echinococcus multilocularis cysteine protease 0.0235 0.1163 0.115
Schistosoma mansoni jumonji domain containing protein 0.0318 0.161 0.3983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0162 0.0771 0.2751
Echinococcus multilocularis histone acetyltransferase MYST2 0.0127 0.0588 0.0574
Schistosoma mansoni ap endonuclease 0.0021 0.0015 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.005 0.0304
Brugia malayi Cathepsin L-like precursor 0.0235 0.1163 0.2107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.0274
Loa Loa (eye worm) hypothetical protein 0.0278 0.1393 0.2505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1163 1
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0074 0.0134
Brugia malayi Cathepsin L-like precursor 0.0235 0.1163 0.2107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1163 0.4151
Loa Loa (eye worm) hypothetical protein 0.0191 0.0928 0.1662
Entamoeba histolytica cysteine protease, putative 0.0128 0.0588 0.499
Entamoeba histolytica hypothetical protein 0.0042 0.0131 0.1005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0128 0.0588 0.1455
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0127 0.0588 0.1422
Plasmodium vivax serine-repeat antigen (SERA) 0.0054 0.0196 0.1589
Echinococcus granulosus histone acetyltransferase MYST2 0.0127 0.0588 0.1422
Loa Loa (eye worm) hypothetical protein 0.0085 0.0361 0.0631
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.005 0.0304
Loa Loa (eye worm) hypothetical protein 0.0073 0.0296 0.0514
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0129 0.0595 0.058
Brugia malayi intermediate filament protein 0.0032 0.0074 0.0134
Schistosoma mansoni bromodomain containing protein 0.0031 0.0073 0.018
Leishmania major cathepsin L-like protease 0.0235 0.1163 1
Onchocerca volvulus 0.0235 0.1163 0.2107
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0196 0.0697
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0494 0.2555 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0382 0.1955 0.1943
Schistosoma mansoni survival motor neuron protein 0.0057 0.0208 0.0514
Onchocerca volvulus 0.0235 0.1163 0.2107
Entamoeba histolytica cysteine protease, putative 0.0054 0.0196 0.1575
Schistosoma mansoni jumonji domain containing protein 0.0049 0.0168 0.0417

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 11.05 ug hr ml-1 Area under curve of the compound in rat at 4 mpk upon peroral administration ChEMBL. 10956206
Cmax (ADMET) = 0.78 ug ml-1 Maximum concentration of the compound in rat at 4 mpk upon peroral administration ChEMBL. 10956206
F (ADMET) = 79 % Oral bioavailability in rat (dose 4 mg/kg) ChEMBL. 10956206
IC50 (functional) = 75 nM Inhibition of concanavalin A (con A)-induced proliferation of human peripheral blood mononuclear cells. ChEMBL. 10956206
IC50 (functional) = 149 nM Inhibition of concanavalin A (con A)-induced proliferation of rat peripheral blood mononuclear cells. ChEMBL. 10956206
IC50 (functional) = 158 nM Inhibition of interleukin-2(IL-2) synthesis in human whole blood stimulated by PMA/ionomycin. ChEMBL. 10956206
IC50 (functional) = 158 nM Inhibition of interleukin-2(IL-2) synthesis in human whole blood stimulated by PMA/ionomycin. ChEMBL. 10956206
T1/2 (ADMET) = 4.8 hr Half-life of the compound in rat at 4 mpk upon peroral administration ChEMBL. 10956206

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10956206

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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