Detailed information for compound 1680933

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 554.648 | Formula: C29H44F6O3
  • H donors: 3 H acceptors: 3 LogP: 8.09 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H]([C@@]1(C)CC[C@H](C1(C)C)/C=C/C=C\1/C[C@@H](O)C[C@@H](C1=C)O)C)CCCC(C(F)(F)F)(C(F)(F)F)O
  • InChi: 1S/C29H44F6O3/c1-18(9-8-13-27(38,28(30,31)32)29(33,34)35)15-19(2)26(6)14-12-22(25(26,4)5)11-7-10-21-16-23(36)17-24(37)20(21)3/h7,10-11,18-19,22-24,36-38H,3,8-9,12-17H2,1-2,4-6H3/b11-7+,21-10-/t18?,19-,22+,23+,24-,26+/m0/s1
  • InChiKey: GAXMDQOFIOCLAS-FVBZYEAGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum plasmepsin IX 0.0035 0.0029 0.049
Echinococcus multilocularis GPCR, family 2 0.0047 0.0085 0.0094
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0109 0.1541
Echinococcus multilocularis snurportin 1 0.0298 0.1208 0.1335
Brugia malayi neuropeptide F receptor 0.0055 0.0121 0.0473
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0011 0.0015
Leishmania major DNA polymerase eta, putative 0.0043 0.0069 0.0907
Brugia malayi Melatonin receptor type 1A 0.0055 0.0121 0.0473
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0121 0.0317
Mycobacterium leprae putative cytochrome p450 0.0035 0.0032 1
Entamoeba histolytica hypothetical protein, conserved 0.0086 0.0261 0.1709
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Toxoplasma gondii microneme protein MIC17C 0.0032 0.002 0.0027
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0035 0.0032 0.0061
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.0463 0.0512
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0035 0.0032 0.0008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0121 0.0134
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0121 0.0134
Brugia malayi hypothetical protein 0.0035 0.0029 0.0115
Onchocerca volvulus 0.0055 0.0121 0.0551
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0177 0.0666 1
Echinococcus multilocularis serotonin receptor 0.0055 0.0121 0.0134
Echinococcus granulosus allatostatin A receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0121 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0086 0.0261 0.0288
Schistosoma mansoni myosin xvIII 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Echinococcus multilocularis sex peptide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0086 0.0261 0.0288
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Onchocerca volvulus 0.0035 0.0029 0.005
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0086 0.0261 0.1709
Trypanosoma brucei glycerol uptake protein, putative 0.0086 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0181
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0121 0.0134
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0121 0.0134
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0121 0.0134
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0086 0.0261 0.1709
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Trypanosoma cruzi glycerol uptake protein, putative 0.0086 0.0261 0.3924
Schistosoma mansoni opsin-like receptor 0.0055 0.0121 0.0134
Schistosoma mansoni lozenge 0.0056 0.0123 0.0136
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0086 0.0261 0.0288
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.0369 0.0967
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0719 0.3089 0.3415
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0522 0.0577
Brugia malayi RE15519p 0.0055 0.0121 0.0473
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0463 0.7111
Trypanosoma brucei unspecified product 0.0187 0.0712 0.0712
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0031 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0035 0.0032 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0443 0.1854 0.4851
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0121 0.0134
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0064 0.0161 0.0178
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis dna polymerase eta 0.0043 0.0069 0.0076
Schistosoma mansoni zinc finger protein 0.0086 0.0261 0.0288
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Onchocerca volvulus 0.0035 0.003 0.0052
Brugia malayi beta-lactamase family protein 0.0035 0.0031 0.0121
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0121 0.0317
Brugia malayi G-protein coupled receptor 0.0055 0.0121 0.0473
Trypanosoma brucei ribonuclease H1 0.0173 0.0647 0.0647
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0035 0.0032 0.0008
Toxoplasma gondii PAN/Apple domain-containing protein 0.0032 0.002 0.0027
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0029 0.0115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0682
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0086 0.0261 0.0288
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0327
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0035 0.0032 0.0008
Plasmodium vivax aspartyl protease, putative 0.0035 0.0029 0.0441
Schistosoma mansoni microtubule-associated protein tau 0.2053 0.9046 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0121 0.0473
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Onchocerca volvulus 0.0035 0.003 0.0052
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0478 0.0528
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0177 0.0666 1
Onchocerca volvulus 0.0443 0.1854 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0035 0.0032 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.0463 0.6652
Echinococcus granulosus histone acetyltransferase KAT2B 0.0177 0.0666 0.0736
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0052 0.0109 0.6784
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Brugia malayi hypothetical protein 0.0035 0.0029 0.0115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis muscleblind protein 0.0145 0.0522 0.0577
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0121 0.0134
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0121 0.0134
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Toxoplasma gondii hypothetical protein 0.0086 0.0261 0.0353
Schistosoma mansoni hypothetical protein 0.0035 0.0032 0.0035
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.0463 0.1805
Toxoplasma gondii microneme protein MIC4 0.0032 0.002 0.0027
Echinococcus granulosus serotonin receptor 0.0055 0.0121 0.0134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0035 0.0032 0.0321
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0035 0.0032 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0261 0.3615
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0029 0.0033
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0035 0.0032 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0121 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0121 0.0134
Brugia malayi Cytochrome P450 family protein 0.0035 0.0032 0.0124
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0121 0.0317
Brugia malayi beta-lactamase 0.0035 0.0031 0.0121
Schistosoma mansoni biogenic amine receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0121 0.0317
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0029 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0035 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0478 0.0528
Onchocerca volvulus 0.0035 0.003 0.0052
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Echinococcus granulosus somatostatin receptor 0.0055 0.0121 0.0134
Brugia malayi GnHR receptor homolog 0.0055 0.0121 0.0473
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) beta-lactamase 0.0035 0.0031 0.0081
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0035 0.0032 0.0061
Onchocerca volvulus 0.0035 0.003 0.0052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0585 0.2489 0.2752
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Trypanosoma cruzi glycerol uptake protein, putative 0.0086 0.0261 0.3924
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0035 0.0032 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0031 0.0034
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0086 0.0261 0.0288
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0031 0.0034
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Brugia malayi cytochrome P450 0.0035 0.0032 0.0124
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0035 0.0032 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0032 0.002 0.0027
Onchocerca volvulus 0.0056 0.0125 0.0572
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0121 0.0134
Toxoplasma gondii microneme protein, putative 0.0032 0.002 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0035 0.0032 0.0008
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0035 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0398 0.1043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0035 0.0032 0.0061
Echinococcus granulosus ribonuclease H1 0.0173 0.0647 0.0715
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0121 0.0134
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0086 0.0261 0.0353
Loa Loa (eye worm) MBOAT family protein 0.0086 0.0261 0.0682
Schistosoma mansoni sterol O-acyltransferase 1 0.0883 0.3821 0.4225
Schistosoma mansoni hypothetical protein 0.0056 0.0125 0.0138
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0121 0.0134
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.003 0.0115
Echinococcus granulosus sterol O acyltransferase 1 0.0883 0.3821 0.4225
Leishmania major cytochrome p450-like protein 0.0035 0.0032 0.0321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0086 0.0261 0.0353
Toxoplasma gondii aspartyl protease 0.0035 0.0029 0.004
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0125 0.0327
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0086 0.0261 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0086 0.0261 0.0288
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0146 0.0162
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Treponema pallidum ribonuclease H (rnhA) 0.0173 0.0647 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0121 0.0317
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) runx1 0.0056 0.0123 0.0323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0121 0.0134
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0121 0.0134
Giardia lamblia Ribonuclease H 0.0173 0.0647 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0121 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0035 0.0032 0.0008
Toxoplasma gondii PAN domain-containing protein 0.0302 0.1225 0.1657
Echinococcus granulosus o acyltransferase membrane bound domain 0.0086 0.0261 0.0288
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0032 1
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0035 0.0032 0.0008
Plasmodium vivax aspartyl protease, putative 0.0035 0.0029 0.0441
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0031 0.0034
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0035 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0077
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0146 0.0528 0.0583
Schistosoma mansoni opsin-like receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0883 0.3821 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0121 0.0134
Trichomonas vaginalis porcupine, putative 0.0086 0.0261 0.3615
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0086 0.0261 0.0288
Echinococcus granulosus g protein coupled receptor 0.0055 0.0121 0.0134
Echinococcus granulosus sex peptide receptor 0.0055 0.0121 0.0134
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0035 0.003 0.0115
Echinococcus granulosus geminin 0.0499 0.2104 0.2326
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0121 0.0134
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.0463 0.0512
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Echinococcus multilocularis tissue type plasminogen activator 0.0056 0.0125 0.0138
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0121 0.0134
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0463 0.0463
Onchocerca volvulus 0.0055 0.0121 0.0551
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0085 0.033
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0121 0.0473
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0064 0.0161 0.0178
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni lipoxygenase 0.0118 0.0402 0.0444
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0121 0.0134
Toxoplasma gondii subtilisin SUB12 0.0032 0.002 0.0027
Toxoplasma gondii hypothetical protein 0.0032 0.002 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hhat protein 0.0086 0.0261 0.0682
Onchocerca volvulus 0.0035 0.003 0.0052
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.0917 0.24
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Plasmodium falciparum plasmepsin V 0.0035 0.0029 0.049
Brugia malayi Protein kinase domain containing protein 0.0056 0.0125 0.0488
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0121 0.0134
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0121 0.0134
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0029 0.0115
Echinococcus multilocularis Protein lozenge 0.0056 0.0123 0.0136
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0035 0.0032 0.0061
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Brugia malayi Dopamine receptor protein 1 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Echinococcus multilocularis microtubule associated protein 2 0.2053 0.9046 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0146 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0029 0.004
Leishmania major cytochrome p450-like protein 0.0035 0.0032 0.0321
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus granulosus microtubule associated protein 2 0.2053 0.9046 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi Cytochrome P450 family protein 0.0052 0.0109 0.0426
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0121 0.0134
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0086 0.0261 0.0288
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0035 0.0032 0.0061
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0086 0.0261 0.0288
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0121 0.0134
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0109 0.0286
Brugia malayi Cytochrome P450 family protein 0.0111 0.0369 0.1441
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0035 0.0032 0.0061
Onchocerca volvulus 0.0035 0.0029 0.005
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0086 0.0261 0.1709
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0032 0.0035
Schistosoma mansoni hypothetical protein 0.0499 0.2104 0.2326
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0146 1
Schistosoma mansoni cathepsin D (A01 family) 0.0431 0.1799 0.1989
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0121 0.0134
Echinococcus multilocularis somatostatin receptor 0.0055 0.0121 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0035 0.0032 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0146 0.1373
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0031 0.031
Trypanosoma brucei cytochrome P450, putative 0.0052 0.0109 0.0109
Entamoeba histolytica acetyltransferase, GNAT family 0.0162 0.06 1
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0035 0.003 0.0052
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0121 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0478 0.0528
Onchocerca volvulus Ribonuclease H1 homolog 0.0173 0.0647 0.3416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0478 0.0528
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Trichomonas vaginalis bromodomain-containing protein, putative 0.0177 0.0666 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0538 0.2096
Brugia malayi Hhat protein 0.0086 0.0261 0.1016
Trypanosoma brucei ingi protein (ORF1) 0.0187 0.0712 0.0712
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0035 0.0032 0.0061
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0146 0.2125
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0146 0.0162
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0035 0.0032 0.0008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0121 0.0134
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0086 0.0261 0.0288
Loa Loa (eye worm) hypothetical protein 0.0145 0.0522 0.1366
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1208 0.3161
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0602 0.2565 0.2835
Echinococcus granulosus neuropeptide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0029 0.0077
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Brugia malayi putative neuropeptide receptor 0.0055 0.0121 0.0473
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0463 0.7111
Toxoplasma gondii microneme protein MIC17B 0.0032 0.002 0.0027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0121 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Toxoplasma gondii microneme protein MIC17A 0.0032 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0682
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi Serotonin receptor 0.0055 0.0121 0.0473
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0146 0.0198
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0085 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.1682 0.7391 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0031 0.0121
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0085 0.0094
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0478 0.0528
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.0463 0.1212
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0121 0.0134
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0121 0.0551
Trypanosoma cruzi GUP1, putative 0.0086 0.0261 0.3924
Loa Loa (eye worm) hypothetical protein 0.0148 0.0538 0.1407
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Brugia malayi larval opioid receptor 0.0055 0.0121 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0261 0.3615
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0035 0.0032 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0035 0.0032 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Entamoeba histolytica vacuolar protein sorting 26 0.0086 0.0261 0.1709
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Trypanosoma cruzi GUP1, putative 0.0086 0.0261 0.3924
Schistosoma mansoni DNA polymerase eta 0.0043 0.0069 0.0076
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0121 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Brugia malayi MH2 domain containing protein 0.0117 0.0398 0.1554
Echinococcus multilocularis 0.0035 0.0032 0.0035
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0121 0.0134
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0035 0.0031 0.0059
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0121 0.0134
Brugia malayi sulfakinin receptor protein 0.0055 0.0121 0.0473
Brugia malayi Dopamine receptor protein 2 0.0055 0.0121 0.0473
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0086 0.0261 0.0288
Schistosoma mansoni hypothetical protein 0.0648 0.2768 0.306
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0121 0.0134
Plasmodium falciparum plasmepsin IV 0.0146 0.0528 0.8791
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0402 0.0444
Brugia malayi hypothetical protein 0.0443 0.1854 0.7228
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0121 0.0317
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis ribonuclease H1 0.0173 0.0647 0.0715
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0035 0.0032 0.0008
Onchocerca volvulus 0.0055 0.0121 0.0551
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0121 0.0134
Entamoeba histolytica hypothetical protein 0.0086 0.0261 0.1709
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0086 0.0261 0.4342
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0035 0.0032 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0032 0.0321
Toxoplasma gondii aspartyl protease ASP1 0.0146 0.0528 0.0714
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0215 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.003 0.0115
Brugia malayi acetyltransferase, GNAT family protein 0.0602 0.2565 1
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0064 0.0161 0.0178
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0116 0.0392 0.1528
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0121 0.0473
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0191 0.0211
Loa Loa (eye worm) hypothetical protein 0.0443 0.1854 0.4851
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0086 0.0261 0.0682
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0121 0.0134
Brugia malayi neuropeptide F receptor 0.0055 0.0121 0.0473
Onchocerca volvulus 0.0035 0.003 0.0052
Echinococcus multilocularis sterol O acyltransferase 1 0.0883 0.3821 0.4225
Onchocerca volvulus 0.0035 0.0031 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0398 0.1043
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0086 0.0261 0.0288
Onchocerca volvulus 0.0055 0.0121 0.0551
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0871 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0035 0.0032 0.0061
Echinococcus granulosus g protein coupled receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis geminin 0.0499 0.2104 0.2326
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0121 0.0134
Leishmania major ribonuclease H1, putative 0.0173 0.0647 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0086 0.0261 0.0288
Toxoplasma gondii hypothetical protein 0.0032 0.002 0.0027
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0146 0.0528 0.0714
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0121 0.0317
Schistosoma mansoni opsin-like receptor 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0035 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Plasmodium vivax aspartyl protease, putative 0.0035 0.0029 0.0441
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0146 0.0528 0.1381
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0086 0.0261 0.0288
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0069 0.0069
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0121 0.0473
Loa Loa (eye worm) hhat protein 0.0086 0.0261 0.0682
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi Pax transcription factor protein 2 0.0233 0.0917 0.3576
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0035 0.0032 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0121 0.0134
Brugia malayi RNA, U transporter 1 0.0079 0.023 0.0898
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Schistosoma mansoni cathepsin D (A01 family) 0.0431 0.1799 0.1989
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus snurportin 1 0.0298 0.1208 0.1335
Leishmania major hypothetical protein, conserved 0.0056 0.0125 0.1789
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0035 0.0032 0.0061
Schistosoma mansoni biogenic amine receptor 0.0055 0.0121 0.0134
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0328 0.1279
Schistosoma mansoni lipoxygenase 0.0082 0.0243 0.0269
Trypanosoma brucei glycerol uptake protein, putative 0.0086 0.0261 0.0261
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0077
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0173 0.0647 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0682
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0146 0.0162
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0116 0.0392 0.0433
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0031 0.0034
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis serotonin receptor 0.0055 0.0121 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0121 0.0134
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Echinococcus granulosus fmrfamide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0029 0.0077
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0121 0.0473
Echinococcus granulosus muscleblind protein 0.0145 0.0522 0.0577
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0538 0.2096
Schistosoma mansoni hypothetical protein 0.0298 0.1208 0.1335
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Brugia malayi RNase H family protein 0.0173 0.0647 0.2521
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0035 0.003 0.0077
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0121 0.0134
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0056 0.0125 0.1877
Schistosoma mansoni hypothetical protein 0.0499 0.2104 0.2326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0085 0.0094
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0031 0.0081
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0121 0.0134
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0086 0.0261 0.3913
Schistosoma mansoni phosphoglucomutase 0.0173 0.0647 0.0715
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0085 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Onchocerca volvulus 0.0086 0.0261 0.1311
Toxoplasma gondii ABC1 family protein 0.0035 0.0031 0.0042
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0478 0.1864
Echinococcus granulosus o acyltransferase membrane bound domain 0.0086 0.0261 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0121 0.0134
Brugia malayi RNase H family protein 0.0173 0.0647 0.2521
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0035 0.0032 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0125 0.1789
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0069 0.0269
Echinococcus granulosus orexin receptor type 2 0.0055 0.0121 0.0134
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.343 0.3791
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0035 0.0032 0.0008
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0035 0.0032 0.0061
Trypanosoma cruzi glycerol uptake protein, putative 0.0086 0.0261 0.3924
Brugia malayi G protein-coupled receptor 0.0055 0.0121 0.0473
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Echinococcus granulosus tissue type plasminogen activator 0.0056 0.0125 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0191 0.0211
Loa Loa (eye worm) acetyltransferase 0.0602 0.2565 0.6711
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0538 0.1407
Plasmodium falciparum plasmepsin I 0.0146 0.0528 0.8791
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0035 0.0032 0.0008
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0032 0.0032
Brugia malayi beta-lactamase family protein 0.0035 0.0031 0.0121
Brugia malayi diacylglycerol acyltransferase 0.0086 0.0261 0.1016
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0035 0.0032 0.0061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0121 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0478 0.0528
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0064 0.0161 0.0178
Plasmodium falciparum plasmepsin VII 0.0035 0.0029 0.049
Leishmania major hypothetical protein, conserved 0.0035 0.0031 0.031
Trichomonas vaginalis ribonuclease H1, putative 0.0173 0.0647 0.9693
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0035 0.0032 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0121 0.0473
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0121 0.0473
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.0463 0.7111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0121 0.0134
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0177 0.0666 0.0901
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0222
Brugia malayi Muscleblind-like protein 0.0145 0.0522 0.2035
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0719 0.3089 0.3415
Brugia malayi Pepsin A precursor 0.0035 0.0029 0.0115
Schistosoma mansoni tumor necrosis factor receptor related 0.0064 0.0161 0.0178
Plasmodium falciparum plasmepsin VI 0.0146 0.0528 0.8791
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0121 0.0317
Schistosoma mansoni cytochrome P450 0.0035 0.0032 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0146 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0162 0.06 1
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi Kringle domain containing protein 0.0056 0.0125 0.0488
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) CYP4Cod1 0.0052 0.0109 0.0286
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Echinococcus granulosus neuropeptide receptor 0.0055 0.0121 0.0134
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0146 0.0528 0.782
Plasmodium vivax plasmepsin V, putative 0.0035 0.0029 0.0441
Loa Loa (eye worm) MBOAT family protein 0.0086 0.0261 0.0682
Echinococcus granulosus GPCR family 2 0.0047 0.0085 0.0094
Trypanosoma cruzi ribonuclease H1, putative 0.0173 0.0647 1
Schistosoma mansoni hypothetical protein 0.0101 0.0328 0.0363
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0121 0.0134
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0602 0.2565 0.2835
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0109 0.0286
Brugia malayi hypothetical protein 0.0071 0.0191 0.0743
Onchocerca volvulus 0.0055 0.0121 0.0551
Onchocerca volvulus 0.0233 0.0917 0.4892
Schistosoma mansoni biogenic amine receptor 0.0055 0.0121 0.0134
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0085 0.0094
Loa Loa (eye worm) hypothetical protein 0.0797 0.3436 0.8991
Brugia malayi G-protein coupled receptor 0.0055 0.0121 0.0473
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0177 0.0666 0.0901
Brugia malayi ORL1-like opioid receptor 0.0055 0.0121 0.0473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0478 0.0528
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0086 0.0261 0.0288
Trypanosoma cruzi ribonuclease H1, putative 0.0173 0.0647 1
Plasmodium vivax aspartyl proteinase, putative 0.0146 0.0528 0.7922
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.0463 0.0512
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0191 0.0211
Schistosoma mansoni adenoreceptor 0.0055 0.0121 0.0134
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0086 0.0261 0.0288
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0035 0.0032 0.0061
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0035 0.0031 0.0059
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0146 0.0528 0.1381
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0031 0.031
Plasmodium vivax plasmepsin IV, putative 0.0146 0.0528 0.7922
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0032 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0029 0.0441
Leishmania major cytochrome p450-like protein 0.0052 0.0109 0.1541
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0121 0.0134
Brugia malayi Serotonin receptor 0.0055 0.0121 0.0473
Plasmodium falciparum plasmepsin III 0.0035 0.0029 0.049
Echinococcus granulosus hypothetical protein 0.0055 0.0121 0.0134
Trichomonas vaginalis transmembrane protein nessy, putative 0.0086 0.0261 0.3615
Loa Loa (eye worm) hypothetical protein 0.0101 0.0328 0.0858
Schistosoma mansoni hypothetical protein 0.0086 0.0261 0.0288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0121 0.0134
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0121 0.0134
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0121 0.0134
Echinococcus granulosus g protein coupled receptor 0.0055 0.0121 0.0134
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0121 0.0473
Leishmania major hypothetical protein, conserved 0.0086 0.0261 0.3924
Loa Loa (eye worm) MBOAT family protein 0.0086 0.0261 0.0682
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0069 0.0907
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0029 0.049
Schistosoma mansoni phosphoglucomutase 0.0173 0.0647 0.0715
Brugia malayi Dopamine receptor 0.0055 0.0121 0.0473
Plasmodium falciparum plasmepsin II 0.0146 0.0528 0.8791
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0215 0.0238
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0121 0.0317
Toxoplasma gondii PAN domain-containing protein 0.0302 0.1225 0.1657
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0086 0.0261 0.0288
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0035 0.0032 0.0061
Echinococcus granulosus dna polymerase eta 0.0043 0.0069 0.0076
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0146 0.0528 0.0583
Plasmodium falciparum cysteine repeat modular protein 1 0.0056 0.0125 0.2083
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0121 0.0134
Toxoplasma gondii kringle domain-containing protein 0.0056 0.0125 0.0169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0478 0.1251
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0146 0.0162
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0035 0.0032 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0121 0.0134
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0116 0.0392 0.1025
Brugia malayi AKH receptor 0.0055 0.0121 0.0473
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0146 0.0528 0.0583
Onchocerca volvulus 0.0055 0.0121 0.0551
Schistosoma mansoni hypothetical protein 0.0071 0.0191 0.0211
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Toxoplasma gondii ribonuclease HI protein 0.0173 0.0647 0.0875
Loa Loa (eye worm) cytochrome P450 0.0035 0.0032 0.0083
Onchocerca volvulus 0.0035 0.003 0.0052
Trypanosoma brucei ingi protein (ORF1) 0.0187 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0145 0.0522 0.1366
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0086 0.0261 0.0682
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0032 0.0321
Schistosoma mansoni histamine h1 receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0086 0.0261 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni phosphoglucomutase 0.0173 0.0647 0.0715
Plasmodium falciparum plasmepsin X 0.0035 0.0029 0.049
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0109 0.1541
Brugia malayi RNase H family protein 0.0173 0.0647 0.2521
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0121 0.0134
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0187 0.0712 0.0712
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0402 0.0444
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0086 0.0261 0.0288
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0121 0.0551
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0085 0.033
Brugia malayi Cytochrome P450 family protein 0.0052 0.0109 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0261 0.3615

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) > 100 % Calcemic effect in vivo in vitamin D-replete normal NMRI mice by daily intraperitoneal injections of compound and 1alpha,25 (OH)2D3 for 7 consecutive days ChEMBL. 12039579
Activity (functional) = 400 % Percent inhibition against HL-60 cell line (50% dose response), relative to 1alpha,25 (OH)2D3 (100% activity) determined in vitro ChEMBL. 12039579
Activity (functional) = 30000 % Percent inhibition against MCF-7 cell line (50% dose response), relative to 1alpha,25 (OH)2D3 (100% activity) determined in vitro ChEMBL. 12039579
Relative affinity (binding) = 60 Displacement of 50% binding of [3H]alpha,25 (OH)2D3 from pig intestinal mucosa Vitamin D3 receptor ChEMBL. 12039579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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