Detailed information for compound 1789653

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.418 | Formula: C19H22N6
  • H donors: 1 H acceptors: 3 LogP: 2.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1
  • InChi: 1S/C19H22N6/c1-24-10-12-25(13-11-24)14-15-6-8-16(9-7-15)17-4-2-3-5-18(17)19-20-22-23-21-19/h2-9H,10-14H2,1H3,(H,20,21,22,23)
  • InChiKey: URDQTPVDLUEXAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Brugia malayi Uncoordinated protein 104 0.0027 0.0093 0.0134
Echinococcus multilocularis beta 1 syntrophin 0.0027 0.0093 0.0093
Trichomonas vaginalis protein transport protein sec7, putative 0.0027 0.0093 0.0411
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0027 0.0093 0.0093
Brugia malayi Dynamin 0.0027 0.0093 0.0134
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0131 0.0131
Toxoplasma gondii Oxysterol-binding protein 0.0027 0.0093 0.2318
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0032 0.0131 1
Echinococcus multilocularis pdz domain containing protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0046 0.0241 0.024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0254 0.0254
Brugia malayi hypothetical protein 0.0206 0.1469 0.2117
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0027 0.0093 0.0093
Leishmania major hypothetical protein, conserved 0.0027 0.0093 0.7091
Loa Loa (eye worm) hypothetical protein 0.0206 0.1469 0.1469
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0027 0.0093 0.0463
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0206 0.1469 0.1469
Entamoeba histolytica PH domain containing protein 0.0027 0.0093 0.0463
Schistosoma mansoni serine/threonine protein kinase 0.1312 1 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.011 0.011
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0018 0.0018
Schistosoma mansoni z-protein (S1r protein) 0.0206 0.1469 0.1469
Trichomonas vaginalis centaurin beta, putative 0.0027 0.0093 0.0411
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0032 0.0131 0.3642
Brugia malayi Bromodomain containing protein 0.0038 0.0177 0.0254
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0032 0.0131 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0027 0.0093 0.0463
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0131 0.0727
Brugia malayi PXA domain containing protein 0.0206 0.1469 0.2117
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.0027 0.0093 0.2318
Brugia malayi Regulator of G protein signaling domain containing protein 0.0206 0.1469 0.2117
Schistosoma mansoni serine/threonine protein kinase 0.0915 0.6939 0.6939
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0371 0.0371
Schistosoma mansoni goodpasture antigen-binding protein 0.0027 0.0093 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.011 0.2897
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0027 0.0093 0.0093
Echinococcus granulosus beta 1 syntrophin 0.0027 0.0093 0.0093
Loa Loa (eye worm) cytohesin 3 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0032 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trichomonas vaginalis hypothetical protein 0.0027 0.0093 0.0411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0254 0.0366
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0032 0.0131 1
Brugia malayi PHD-finger family protein 0.0026 0.0086 0.0124
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0131 0.0131
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0027 0.0093 0.0134
Brugia malayi Pre-SET motif family protein 0.0029 0.011 0.0158
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.0013
Echinococcus multilocularis Pleckstrin y 0.0027 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0027 0.0093 0.0093
Trichomonas vaginalis centaurin gamma, putative 0.0027 0.0093 0.0411
Echinococcus multilocularis cpg binding protein 0.0031 0.0123 0.0123
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0371 0.0371
Echinococcus multilocularis oxysterol binding protein 3 0.0027 0.0093 0.0093
Trypanosoma brucei PH domain containing protein, putative 0.0027 0.0093 0.7091
Schistosoma mansoni axis inhibition protein axin 0.0206 0.1469 0.1469
Echinococcus multilocularis regulator of G protein signaling 7 0.0206 0.1469 0.1469
Entamoeba histolytica p21-activated kinase 0.0032 0.0131 0.0727
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Echinococcus granulosus cpg binding protein 0.0031 0.0123 0.0123
Echinococcus granulosus myotubularin protein 13 0.0027 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0032 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1469 0.8872
Brugia malayi regulator of G-protein signaling rgs-7 0.0206 0.1469 0.2117
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0026 0.5
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) hypothetical protein 0.0206 0.1469 0.1469
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0027 0.0093 0.0411
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0235 0.0235
Echinococcus granulosus serine/threonine protein kinase 0.0032 0.0131 0.0131
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0027 0.0093 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.1997
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0027 0.0093 0.0093
Trypanosoma cruzi PH domain containing protein, putative 0.0027 0.0093 0.7091
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0041 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) hypothetical protein 0.0206 0.1469 0.1469
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0068 0.0068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0235 0.0338
Echinococcus granulosus expressed protein 0.0206 0.1469 0.1469
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Brugia malayi Oxysterol binding protein 0.0027 0.0093 0.0134
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0041 0.0195 0.0195
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0032 0.0131 1
Leishmania major protein kinase, putative 0.0032 0.0131 1
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Schistosoma mansoni regulator of G protein signaling 0.0206 0.1469 0.1469
Echinococcus multilocularis Pleckstrin y 0.0027 0.0093 0.0093
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0027 0.0093 0.0093
Brugia malayi MAX-1A 0.0027 0.0093 0.0134
Echinococcus multilocularis Ras associated and pleckstrin y 0.0027 0.0093 0.0093
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0032 0.0131 1
Brugia malayi Pre-SET motif family protein 0.0202 0.1438 0.2072
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0027 0.0093 0.0411
Entamoeba histolytica hypothetical protein 0.0027 0.0093 0.0463
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0027 0.0093 0.0093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0131 0.0727
Brugia malayi RNA binding protein 0.0063 0.0371 0.0534
Brugia malayi Protein kinase domain containing protein 0.0032 0.0131 0.0189
Echinococcus granulosus cytohesin 1 0.0027 0.0093 0.0093
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0371 0.037
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0371 0.0371
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2931 0.2931
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0915 0.6939 0.6939
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0032 0.0131 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.011 0.011
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091
Entamoeba histolytica hypothetical protein 0.0032 0.0131 0.0727
Echinococcus multilocularis actin binding protein anillin 0.0027 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0709 0.5353 0.5353
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0027 0.0093 0.6364
Echinococcus multilocularis Rho GTPase activating protein 24 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) RNA binding protein 0.0063 0.0371 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0027 0.0093 0.0411
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0915 0.6939 1
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091
Schistosoma mansoni regulator of G protein signaling 0.0206 0.1469 0.1469
Schistosoma mansoni serine/threonine protein kinase 0.1312 1 1
Echinococcus multilocularis axis inhibition protein axin 0.0206 0.1469 0.1469
Trypanosoma cruzi NIMA-related kinase, putative 0.0032 0.0131 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0027 0.0093 0.0463
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0013 0.0013
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0032 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1469 0.8872
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0027 0.0093 0.0093
Loa Loa (eye worm) PH domain-containing protein 0.0027 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0027 0.0093 0.0093
Plasmodium falciparum oxysterol-binding protein, putative 0.0027 0.0093 0.6364
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0093 0.0134
Echinococcus granulosus axis inhibition protein axin 0.0206 0.1469 0.1469
Echinococcus granulosus dynamin 1 0.0027 0.0093 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0254 0.0254
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Loa Loa (eye worm) hypothetical protein 0.0044 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Echinococcus granulosus axis inhibition protein axin 0.0206 0.1469 0.1469
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0314 1
Echinococcus multilocularis GRB2 associated binding protein 3 0.0027 0.0093 0.0093
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2931 0.2931
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0027 0.0093 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091
Loa Loa (eye worm) rho-GTPase-activating 0.0027 0.0093 0.0093
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1469 0.8872
Entamoeba histolytica hypothetical protein 0.0206 0.1469 1
Leishmania major folate/biopterin transporter, putative 0.0032 0.0131 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0235 0.0235
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1652 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0241 0.024
Loa Loa (eye worm) hypothetical protein 0.0206 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Brugia malayi Cadps2 protein 0.0027 0.0093 0.0134
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0027 0.0093 0.7091
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0032 0.0131 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1312 1 1
Echinococcus multilocularis axis inhibition protein axin 0.0206 0.1469 0.1469
Schistosoma mansoni oxysterol-binding protein 1 0.0027 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Echinococcus multilocularis calcium dependent secretion activator 1 0.0027 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) Plekhf2 protein 0.0027 0.0093 0.0093
Echinococcus granulosus regulator of G protein signaling 7 0.0206 0.1469 0.1469
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Brugia malayi Regulator of G protein signaling domain containing protein 0.0206 0.1469 0.2117
Schistosoma mansoni cpg binding protein 0.0028 0.0097 0.0097
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0371 0.0371
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0027 0.0093 0.0411
Plasmodium vivax SET domain protein, putative 0.0029 0.011 0.7956
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0027 0.0093 0.7091
Brugia malayi Oxysterol-binding protein 0.0027 0.0093 0.0134
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0032 0.0131 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.1997
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0027 0.0093 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0371 0.0371
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0206 0.1469 0.1469
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.1997
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0068 0.0068
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0093 0.0463
Schistosoma mansoni vav2 0.0027 0.0093 0.0093
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0027 0.0093 0.0134
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0371 0.037
Trypanosoma cruzi NIMA-related kinase, putative 0.0032 0.0131 1
Trypanosoma cruzi PH domain containing protein, putative 0.0027 0.0093 0.7091
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0026
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0709 0.5353 0.5353
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Entamoeba histolytica hypothetical protein 0.0206 0.1469 1
Brugia malayi regulator of G-protein signaling egl-10 0.0206 0.1469 0.2117
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Schistosoma mansoni goodpasture antigen-binding protein 0.0027 0.0093 0.0093
Brugia malayi Dynamin 0.0027 0.0093 0.0134
Loa Loa (eye worm) RGS-3 protein 0.0206 0.1469 0.1469
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.011 0.011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0158 0.0158
Brugia malayi TAR-binding protein 0.0063 0.0371 0.0534
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0032 0.0131 0.0645
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0241 0.0241
Echinococcus granulosus tar DNA binding protein 0.0063 0.0371 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1469 0.8872
Echinococcus granulosus Oxysterol binding protein 11 0.0027 0.0093 0.0093
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0027 0.0093 0.6364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0235 0.0235
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.0093 0.6364
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0093 0.0093
Echinococcus granulosus regulator of G protein signaling 7 0.0206 0.1469 0.1469
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0027 0.0093 0.0093
Trichomonas vaginalis centaurin/arf, putative 0.0027 0.0093 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1106 0.8413 0.8413
Brugia malayi probable spectrin beta chain 0.0027 0.0093 0.0134
Trypanosoma cruzi PH domain containing protein, putative 0.0027 0.0093 0.7091
Brugia malayi CXXC zinc finger family protein 0.0028 0.0097 0.0139
Echinococcus granulosus DCC interacting protein 13 beta 0.0027 0.0093 0.0093
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0027 0.0093 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0097 0.0097
Echinococcus multilocularis beta adrenergic receptor kinase 0.1312 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.0013
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0136
Schistosoma mansoni zinc finger protein 0.0027 0.0093 0.0093
Schistosoma mansoni oxysterol-binding protein 1 0.0027 0.0093 0.0093
Brugia malayi Cytohesin 3 0.0027 0.0093 0.0134
Trypanosoma brucei protein kinase, putative 0.0032 0.0131 1
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0709 0.5353 0.5353
Schistosoma mansoni centaurin alpha 0.0027 0.0093 0.0093
Echinococcus multilocularis regulator of G protein signaling 3 0.0206 0.1469 0.1469
Schistosoma mansoni rho gtpase activating protein 0.0027 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Echinococcus multilocularis cytohesin 1 0.0027 0.0093 0.0093
Leishmania major protein kinase, putative 0.0032 0.0131 1
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0027 0.0093 0.0093
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.0093 0.6364
Schistosoma mansoni growth factor receptor-bound protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) PXA domain-containing protein 0.0206 0.1469 0.1469
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0027 0.0093 0.0093
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0032 0.0131 1
Schistosoma mansoni axis inhibition protein axin 0.0206 0.1469 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0235 0.0235
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Echinococcus granulosus zinc finger protein 0.0021 0.0045 0.0045
Echinococcus multilocularis expressed protein 0.0206 0.1469 0.1469
Entamoeba histolytica hypothetical protein 0.0032 0.0131 0.0727
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Brugia malayi hypothetical protein 0.0027 0.0093 0.0134
Schistosoma mansoni regulator of G protein signaling 0.0206 0.1469 0.1469
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0027 0.0093 0.7091
Onchocerca volvulus 0.0229 0.1652 1
Echinococcus multilocularis oxysterol binding protein 9 0.0027 0.0093 0.0093
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0353 0.0353
Echinococcus granulosus Regulator of G protein signaling 20 0.0206 0.1469 0.1469
Echinococcus granulosus oxysterol binding protein 1 0.0027 0.0093 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0032 0.0131 0.0645
Entamoeba histolytica PH domain containing protein 0.0027 0.0093 0.0463
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0027 0.0093 0.0093
Echinococcus multilocularis regulator of G protein signaling 7 0.0206 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.0206 0.1469 0.1469
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0027 0.0093 0.0411
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Echinococcus multilocularis regulator of G protein signaling 3 0.0206 0.1469 0.1469
Trichomonas vaginalis alpha chimerin, putative 0.0027 0.0093 0.0411
Loa Loa (eye worm) syntrophin-1 0.0027 0.0093 0.0093
Echinococcus multilocularis oxysterol binding protein 1 0.0027 0.0093 0.0093
Trypanosoma brucei rac serine-threonine kinase, putative 0.0032 0.0131 1
Schistosoma mansoni hypothetical protein 0.0395 0.2931 0.2931
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1438 0.1438
Schistosoma mansoni hypothetical protein 0.0021 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0371 0.037
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0131 0.0727
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0032 0.0131 1
Echinococcus granulosus calcium dependent secretion activator 1 0.0027 0.0093 0.0093
Schistosoma mansoni syntrophin 0.0027 0.0093 0.0093
Leishmania major hypothetical protein, conserved 0.0027 0.0093 0.7091
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0206 0.1469 0.1469
Plasmodium falciparum calcium-dependent protein kinase 7 0.0032 0.0131 1
Onchocerca volvulus 0.0029 0.011 0.0107
Loa Loa (eye worm) oxysterol binding protein 0.0027 0.0093 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Onchocerca volvulus 0.0028 0.0097 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0027 0.0093 0.0463
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.5
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0027 0.0093 0.0093
Echinococcus granulosus pdz domain containing protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) uncoordinated protein 104 0.0027 0.0093 0.0093
Schistosoma mansoni regulator of G protein signaling 0.0206 0.1469 0.1469
Toxoplasma gondii hypothetical protein 0.0027 0.0093 0.2318
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Schistosoma mansoni regulator of G protein signaling 0.0206 0.1469 0.1469
Brugia malayi hypothetical protein 0.0206 0.1469 0.2117
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0206 0.1469 1
Brugia malayi Plekhf2 protein 0.0027 0.0093 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Schistosoma mansoni bromodomain containing protein 0.0065 0.0381 0.0381
Echinococcus multilocularis dynamin 1 0.0027 0.0093 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Echinococcus granulosus oxysterol binding protein 3 0.0027 0.0093 0.0093
Echinococcus multilocularis Oxysterol binding protein 11 0.0027 0.0093 0.0093
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0093 0.0134
Echinococcus multilocularis zinc finger protein 0.0021 0.0045 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0235 0.0235
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0206 0.1469 0.1469
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0241 0.024
Brugia malayi PH domain containing protein 0.0027 0.0093 0.0134
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0027 0.0093 0.0463
Echinococcus granulosus oxysterol binding protein 9 0.0027 0.0093 0.0093
Plasmodium falciparum PH domain-containing protein, putative 0.0027 0.0093 0.6364
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0032 0.0131 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0206 0.1469 0.1469
Brugia malayi Bromodomain containing protein 0.0076 0.047 0.0678
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0026 0.5
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0027 0.0093 0.6364
Loa Loa (eye worm) hypothetical protein 0.007 0.0425 0.0425
Echinococcus multilocularis pleckstrin y domain containing family A 0.0027 0.0093 0.0093
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0027 0.0093 0.0411
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0027 0.0093 0.0093
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0206 0.1469 0.1469
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.015 0.1037 0.1037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0345 0.0345
Echinococcus multilocularis regulator of G protein signaling 0.0206 0.1469 0.1469
Echinococcus granulosus regulator of G protein signaling 3 0.0206 0.1469 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0235 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0097 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0206 0.1469 0.8872
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091
Echinococcus multilocularis Regulator of G protein signaling 20 0.0206 0.1469 0.1469
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.1997
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0038 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Schistosoma mansoni dynamin 0.0027 0.0093 0.0093
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0709 0.5353 0.5353
Echinococcus granulosus regulator of G protein signaling 3 0.0206 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.0206 0.1469 0.1469
Echinococcus multilocularis Pleckstrin y 0.0027 0.0093 0.0093
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0027 0.0093 0.0093
Echinococcus granulosus Rho GTPase activating protein 24 0.0027 0.0093 0.0093
Brugia malayi Syntrophin-1 0.0027 0.0093 0.0134
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0131 0.0131
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0254 0.0366
Schistosoma mansoni zinc finger protein 0.0021 0.0045 0.0045
Leishmania major serine/threonine-protein kinase a, putative 0.0032 0.0131 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Onchocerca volvulus 0.015 0.1037 0.6051
Echinococcus granulosus GRB2 associated binding protein 3 0.0027 0.0093 0.0093
Trichomonas vaginalis kinesin light chain, putative 0.0027 0.0093 0.0411
Echinococcus granulosus pleckstrin y domain containing family A 0.0027 0.0093 0.0093
Schistosoma mansoni myotubularin-related protein 0.0027 0.0093 0.0093
Echinococcus granulosus Pleckstrin y 0.0027 0.0093 0.0093
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Brugia malayi Pleckstrin Homology Domain 0.0027 0.0093 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0235 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0093 0.6364
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0137 0.0197
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0027 0.0093 0.0093
Trypanosoma cruzi PH domain containing protein, putative 0.0027 0.0093 0.7091
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0027 0.0093 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Trypanosoma cruzi Protein kinase B 0.0032 0.0131 1
Echinococcus multilocularis rac serine:threonine kinase 0.0032 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0709 0.5353 0.7714
Echinococcus multilocularis myotubularin protein 13 0.0027 0.0093 0.0093
Plasmodium vivax PH domain containing protein 0.0027 0.0093 0.6364
Entamoeba histolytica ARF GTPase activating protein, putative 0.0027 0.0093 0.0463
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0032 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0093 0.0411
Toxoplasma gondii protein kinase domain-containing protein 0.0032 0.0131 0.3642
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0038
Echinococcus granulosus G protein coupled receptor kinase 1 0.1106 0.8413 0.8413
Schistosoma mansoni hypothetical protein 0.0027 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0027 0.0093 0.0093
Brugia malayi hypothetical protein 0.015 0.1037 0.1494
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0131 0.0727
Schistosoma mansoni zinc finger protein 0.0027 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0093
Brugia malayi TBC domain containing protein 0.0027 0.0093 0.0134
Entamoeba histolytica hypothetical protein 0.0027 0.0093 0.0463
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0027 0.0093 0.0093
Brugia malayi A-kinase anchor protein 10, precursor 0.0206 0.1469 0.2117
Echinococcus granulosus Pleckstrin y 0.0027 0.0093 0.0093
Echinococcus multilocularis DCC interacting protein 13 beta 0.0027 0.0093 0.0093
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0027 0.0093 0.0134
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0131 0.0727
Echinococcus granulosus Pleckstrin y 0.0027 0.0093 0.0093
Trichomonas vaginalis centaurin alpha, putative 0.0027 0.0093 0.0411
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0027 0.0093 0.6364
Brugia malayi PXA domain containing protein 0.0206 0.1469 0.2117
Trichomonas vaginalis centaurin/arf, putative 0.0027 0.0093 0.0411
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0371 0.0534
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0032 0.0131 1
Toxoplasma gondii AtPH1 family protein 0.0027 0.0093 0.2318
Trichomonas vaginalis protein transport protein sec7, putative 0.0027 0.0093 0.0411
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0158 0.0158
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0027 0.0093 0.0463
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0131 0.0727
Schistosoma mansoni dynamin 0.0027 0.0093 0.0093
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0027 0.0093 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1469 0.8872
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0131 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1469 0.8872
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0353 0.0353
Entamoeba histolytica protein kinase, putative 0.0032 0.0131 0.0727
Entamoeba histolytica hypothetical protein 0.0027 0.0093 0.0463
Entamoeba histolytica PH domain containing protein 0.0027 0.0093 0.0463
Toxoplasma gondii phosphatidylinositol transfer protein 0.0027 0.0093 0.2318
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0027 0.0093 0.0463
Entamoeba histolytica hypothetical protein 0.0027 0.0093 0.0463
Trypanosoma cruzi hypothetical protein 0.0027 0.0093 0.7091

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 92 % Inhibition of ACE (unknown origin) using Hippuryl-His-Leu as substrate at 10 ug incubated for 10 min prior to substrate addition measured after 45 min by spectrophotometric analysis relative to control ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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