TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.267 | Formula: C18H25Cl2O6P
H donors: 0 H acceptors: 2 LogP: 5.24 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC(P1(=O)OCC(CO1)(C)C)OC(=O)COc1ccc(cc1Cl)Cl
InChi: 1S/C18H25Cl2O6P/c1-4-5-6-17(27(22)24-11-18(2,3)12-25-27)26-16(21)10-23-15-8-7-13(19)9-14(15)20/h7-9,17H,4-6,10-12H2,1-3H3
InChiKey: CTNHCXPYSXPAID-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0037	0.0125	0.0358
Loa Loa (eye worm)	oxysterol binding protein	0.0037	0.0125	0.0125
Plasmodium vivax	SET domain protein, putative	0.0032	0.0092	0.1384
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0092	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0225	0.1215	0.884
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0225	0.1215	0.884
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Loa Loa (eye worm)	hypothetical protein	0.003	0.0082	0.0082
Brugia malayi	AMP-binding enzyme family protein	0.003	0.0082	0.0212
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0037	0.0125	0.012
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0092	0.0087
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0092	0.0087
Entamoeba histolytica	hypothetical protein	0.0225	0.1215	1
Brugia malayi	Uncoordinated protein 104	0.0037	0.0125	0.0322
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.012
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0005	0.0014
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Onchocerca volvulus		0.0037	0.0125	0.0358
Loa Loa (eye worm)	RGS-3 protein	0.0225	0.1215	0.1215
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0102	0.0501	1
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0037	0.0125	0.7052
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0037	0.0125	0.0125
Toxoplasma gondii	AtPH1 family protein	0.0037	0.0125	0.7052
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0043	0.0157	0.0157
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0043	0.0157	0.3541
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0037	0.0125	0.0125
Loa Loa (eye worm)	syntrophin-1	0.0037	0.0125	0.0125
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0225	0.1215	0.121
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0092	0.0087
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Trichomonas vaginalis	conserved hypothetical protein	0.0225	0.1215	0.884
Leishmania major	folate/biopterin transporter, putative	0.0043	0.0157	0.2365
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Brugia malayi	AMP-binding enzyme family protein	0.0102	0.0501	0.1288
Echinococcus granulosus	axis inhibition protein axin	0.0225	0.1215	0.121
Onchocerca volvulus		0.0037	0.0125	0.0358
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0037	0.0125	0.012
Echinococcus granulosus	calcium dependent secretion activator 1	0.0037	0.0125	0.012
Echinococcus multilocularis	expressed protein	0.0225	0.1215	0.121
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Brugia malayi	MAX-1A	0.0037	0.0125	0.0322
Trypanosoma brucei	protein kinase, putative	0.0043	0.0157	1
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0037	0.0125	0.2497
Onchocerca volvulus		0.0251	0.1364	1
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Brugia malayi	Oxysterol-binding protein	0.0037	0.0125	0.0322
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0037	0.0125	0.012
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0082	0.0546
Echinococcus granulosus	pleckstrin y domain containing family A	0.0037	0.0125	0.012
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1215	0.1215
Onchocerca volvulus		0.003	0.0082	0.0023
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trichomonas vaginalis	conserved hypothetical protein	0.0225	0.1215	0.884
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0037	0.0125	0.7052
Echinococcus multilocularis	Oxysterol binding protein 11	0.0037	0.0125	0.012
Schistosoma mansoni	serine/threonine protein kinase	0.1739	1	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0079	0.0079
Echinococcus granulosus	expressed protein	0.0225	0.1215	0.121
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.1187	0.1187
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0327	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.003	0.0082	0.0546
Brugia malayi	Pre-SET motif family protein	0.0032	0.0092	0.0236
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.012
Trypanosoma cruzi	PH domain containing protein, putative	0.0037	0.0125	0.7052
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0005	0.0014
Onchocerca volvulus		0.0037	0.0125	0.0358
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Trichomonas vaginalis	hypothetical protein	0.0037	0.0125	0.0335
Brugia malayi	Cytohesin 3	0.0037	0.0125	0.0322
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0037	0.0125	0.0379
Leishmania major	hypothetical protein, conserved	0.0037	0.0125	0.1667
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.003	0.0082	0.3023
Brugia malayi	Pre-SET motif family protein	0.022	0.1187	0.3053
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0118	0.0303
Mycobacterium ulcerans	acyl-CoA synthetase	0.0102	0.0501	1
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0037	0.0125	0.012
Schistosoma mansoni	dynamin	0.0037	0.0125	0.012
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0102	0.0501	1
Trypanosoma cruzi	PH domain containing protein, putative	0.0037	0.0125	0.7052
Echinococcus multilocularis	beta 1 syntrophin	0.0037	0.0125	0.012
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1215	0.1215
Leishmania major	4-coumarate:coa ligase-like protein	0.0102	0.0501	1
Trichomonas vaginalis	centaurin gamma, putative	0.0037	0.0125	0.0335
Trichomonas vaginalis	centaurin beta, putative	0.0037	0.0125	0.0335
Schistosoma mansoni	axis inhibition protein axin	0.0225	0.1215	0.121
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0037	0.0125	0.012
Leishmania major	serine/threonine-protein kinase a, putative	0.0043	0.0157	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0043	0.0157	1
Entamoeba histolytica	PH domain containing protein	0.0037	0.0125	0.0379
Echinococcus granulosus	DCC interacting protein 13 beta	0.0037	0.0125	0.012
Echinococcus multilocularis	Pleckstrin y	0.0037	0.0125	0.012
Onchocerca volvulus	outspread protein homolog	0.0037	0.0125	0.0358
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0225	0.1215	0.121
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1215	0.1215
Plasmodium falciparum	PH domain-containing protein, putative	0.0037	0.0125	0.2497
Trichomonas vaginalis	alpha chimerin, putative	0.0037	0.0125	0.0335
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0037	0.0125	0.7052
Echinococcus granulosus	regulator of G protein signaling 7	0.0225	0.1215	0.121
Trichomonas vaginalis	set domain proteins, putative	0.0251	0.1364	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0102	0.0501	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0092	0.0087
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0037	0.0125	0.012
Echinococcus multilocularis	regulator of G protein signaling 7	0.0225	0.1215	0.121
Leishmania major	4-coumarate:coa ligase-like protein	0.0102	0.0501	1
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Brugia malayi	Cadps2 protein	0.0037	0.0125	0.0322
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Entamoeba histolytica	PH domain containing protein	0.0037	0.0125	0.0379
Schistosoma mansoni	lamin	0.0029	0.0079	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0102	0.0501	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Plasmodium falciparum	oxysterol-binding protein, putative	0.0037	0.0125	0.2497
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0327	0.6071
Schistosoma mansoni	regulator of G protein signaling	0.0225	0.1215	0.121
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0043	0.0157	1
Trypanosoma cruzi	PH domain containing protein, putative	0.0037	0.0125	0.7052
Loa Loa (eye worm)	oxidoreductase	0.003	0.0082	0.0082
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0125	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.003	0.0082	0.3023
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1215	0.1215
Schistosoma mansoni	myotubularin-related protein	0.0037	0.0125	0.012
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.012
Echinococcus granulosus	regulator of G protein signaling 3	0.0225	0.1215	0.121
Echinococcus granulosus	Rho GTPase activating protein 24	0.0037	0.0125	0.012
Brugia malayi	Pleckstrin Homology Domain	0.0037	0.0125	0.0322
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Brugia malayi	Plekhf2 protein	0.0037	0.0125	0.0322
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0157	0.0657
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Echinococcus multilocularis	oxysterol binding protein 1	0.0037	0.0125	0.012
Plasmodium vivax	acyl-CoA synthetase, putative	0.0076	0.0351	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0225	0.1215	0.3126
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1739	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0102	0.0501	1
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1514	0.8693	0.8693
Echinococcus granulosus	GRB2 associated binding protein 3	0.0037	0.0125	0.012
Echinococcus multilocularis	lamin dm0	0.0029	0.0079	0.0074
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0037	0.0125	0.012
Leishmania major	4-coumarate:coa ligase-like protein	0.0102	0.0501	1
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0225	0.1215	0.121
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0043	0.0157	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0125	0.0379
Echinococcus multilocularis	Pleckstrin y	0.0037	0.0125	0.012
Onchocerca volvulus		0.003	0.0082	0.0023
Echinococcus multilocularis	rac serine:threonine kinase	0.0043	0.0157	0.0151
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.003	0.0082	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.003	0.0082	0.3023
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0043	0.0157	1
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0037	0.0125	0.0379
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0079	0.0074
Brugia malayi	AMP-binding enzyme family protein	0.0102	0.0501	0.1288
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0037	0.0125	0.012
Brugia malayi	hypothetical protein	0.0024	0.005	0.0129
Echinococcus granulosus	Pleckstrin y	0.0037	0.0125	0.012
Entamoeba histolytica	hypothetical protein	0.0225	0.1215	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Echinococcus granulosus	dynamin 1	0.0037	0.0125	0.012
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0037	0.0125	0.0335
Mycobacterium ulcerans	hypothetical protein	0.0102	0.0501	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0102	0.0501	1
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0043	0.0157	0.3541
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Brugia malayi	PXA domain containing protein	0.0225	0.1215	0.3126
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0037	0.0125	0.2497
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0037	0.0125	0.0335
Schistosoma mansoni	syntrophin	0.0037	0.0125	0.012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0125	0.2497
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0037	0.0125	0.012
Onchocerca volvulus		0.003	0.0082	0.0023
Entamoeba histolytica	hypothetical protein	0.0037	0.0125	0.0379
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.046	0.2581	0.2581
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.003	0.0082	0.0546
Schistosoma mansoni	axis inhibition protein axin	0.0225	0.1215	0.121
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Schistosoma mansoni	acetyl-CoA synthetase	0.003	0.0082	0.0077
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0082	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0037	0.0125	0.0322
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.003	0.0082	0.3023
Echinococcus multilocularis	oxysterol binding protein 3	0.0037	0.0125	0.012
Brugia malayi	AMP-binding enzyme family protein	0.003	0.0082	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Trichomonas vaginalis	conserved hypothetical protein	0.0225	0.1215	0.884
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.003	0.0082	0.0082
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0043	0.0157	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.003	0.0082	0.3023
Plasmodium vivax	PH domain containing protein	0.0037	0.0125	0.2497
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0037	0.0125	0.012
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0037	0.0125	0.012
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0085	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0215
Schistosoma mansoni	oxysterol-binding protein 1	0.0037	0.0125	0.012
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0037	0.0125	0.0379
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.003	0.0082	0.0077
Entamoeba histolytica	hypothetical protein	0.0037	0.0125	0.0379
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.003	0.0082	0.0715
Echinococcus multilocularis	dynamin 1	0.0037	0.0125	0.012
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0037	0.0125	0.012
Schistosoma mansoni	serine/threonine protein kinase	0.1739	1	1
Echinococcus multilocularis	Pleckstrin y	0.0037	0.0125	0.012
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0125	0.0322
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.003	0.0082	0.0546
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.003	0.0082	0.0546
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0043	0.0157	0.2365
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0157	0.0657
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0037	0.0125	0.2497
Echinococcus granulosus	oxysterol binding protein 3	0.0037	0.0125	0.012
Brugia malayi	intermediate filament protein	0.0029	0.0079	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0043	0.0157	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0225	0.1215	0.3126
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0037	0.0125	0.0335
Schistosoma mansoni	goodpasture antigen-binding protein	0.0037	0.0125	0.012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0037	0.0125	0.2497
Brugia malayi	probable spectrin beta chain	0.0037	0.0125	0.0322
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0037	0.0125	0.012
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.046	0.2581	0.2577
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0043	0.0157	1
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Loa Loa (eye worm)	hypothetical protein	0.003	0.0082	0.0082
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0043	0.0157	1
Echinococcus multilocularis	axis inhibition protein axin	0.0225	0.1215	0.121
Echinococcus granulosus	lamin	0.0029	0.0079	0.0074
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0037	0.0125	0.012
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0079	0.0204
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0082	0.0546
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0043	0.0157	0.058
Schistosoma mansoni	serine/threonine protein kinase	0.0686	0.3887	0.3884
Entamoeba histolytica	hypothetical protein	0.0037	0.0125	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1215	0.1215
Plasmodium falciparum	acyl-CoA synthetase	0.0076	0.0351	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0225	0.1215	0.3126
Mycobacterium ulcerans	acyl-CoA synthetase	0.0102	0.0501	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0043	0.0157	0.0151
Echinococcus granulosus	regulator of G protein signaling 7	0.0225	0.1215	0.121
Schistosoma mansoni	zinc finger protein	0.0037	0.0125	0.012
Onchocerca volvulus		0.0037	0.0125	0.0358
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0043	0.0157	0.2365
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0037	0.0125	0.0335
Leishmania major	protein kinase, putative	0.0043	0.0157	0.2365
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.046	0.2581	0.2581
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0037	0.0125	0.012
Echinococcus multilocularis	oxysterol binding protein 9	0.0037	0.0125	0.012
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0037	0.0125	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0037	0.0125	0.012
Brugia malayi	AMP-binding enzyme family protein	0.003	0.0082	0.0212
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Entamoeba histolytica	hypothetical protein, conserved	0.0037	0.0125	0.0379
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.003	0.0082	0.0546
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Entamoeba histolytica	hypothetical protein	0.0043	0.0157	0.0657
Trichomonas vaginalis	conserved hypothetical protein	0.0225	0.1215	0.884
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0092	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0501	0.0501
Trichomonas vaginalis	centaurin/arf, putative	0.0037	0.0125	0.0335
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0037	0.0125	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0501	0.0501
Plasmodium vivax	acetyl-CoA synthetase, putative	0.003	0.0082	0.1071
Echinococcus granulosus	Pleckstrin y	0.0037	0.0125	0.012
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0037	0.0125	0.012
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0327	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0024	0.005	0.005
Echinococcus multilocularis	regulator of G protein signaling	0.0225	0.1215	0.121
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0037	0.0125	0.0125
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0157	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0036	0.0118	0.0113
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.003	0.0082	0.0082
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0037	0.0125	0.012
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0037	0.0125	0.012
Echinococcus multilocularis	axis inhibition protein axin	0.0225	0.1215	0.121
Trichomonas vaginalis	protein transport protein sec7, putative	0.0037	0.0125	0.0335
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.003	0.0082	0.0077
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0037	0.0125	0.012
Onchocerca volvulus		0.0037	0.0125	0.0358
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trypanosoma brucei	PH domain containing protein, putative	0.0037	0.0125	0.7052
Echinococcus multilocularis	myotubularin protein 13	0.0037	0.0125	0.012
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0043	0.0157	1
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.003	0.0082	0.3023
Brugia malayi	Dynamin	0.0037	0.0125	0.0322
Schistosoma mansoni	lamin	0.0029	0.0079	0.0074
Entamoeba histolytica	hypothetical protein	0.0037	0.0125	0.0379
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0037	0.0125	0.012
Echinococcus multilocularis	regulator of G protein signaling 7	0.0225	0.1215	0.121
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0351
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0043	0.0157	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0102	0.0501	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.012
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0043	0.0157	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0157	0.0657
Brugia malayi	AMP-binding enzyme family protein	0.003	0.0082	0.0212
Toxoplasma gondii	hypothetical protein	0.0037	0.0125	0.7052
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1514	0.8693	0.8693
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0037	0.0125	0.0322
Brugia malayi	Syntrophin-1	0.0037	0.0125	0.0322
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0225	0.1215	0.1215
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0076	0.0351	0.5
Echinococcus granulosus	beta 1 syntrophin	0.0037	0.0125	0.012
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trypanosoma cruzi	PH domain containing protein, putative	0.0037	0.0125	0.7052
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0037	0.0125	0.012
Echinococcus multilocularis	actin binding protein anillin	0.0037	0.0125	0.012
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trypanosoma cruzi	hypothetical protein	0.0037	0.0125	0.7052
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0225	0.1215	0.3126
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1215	0.1215
Toxoplasma gondii	hypothetical protein	0.0037	0.0125	0.7052
Trypanosoma cruzi	NIMA-related kinase, putative	0.0043	0.0157	1
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0037	0.0125	0.7052
Echinococcus granulosus	intermediate filament protein	0.0029	0.0079	0.0074
Trichomonas vaginalis	protein transport protein sec7, putative	0.0037	0.0125	0.0335
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Onchocerca volvulus	Putative zinc finger protein	0.0037	0.0125	0.0358
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0215	0.0552
Brugia malayi	Oxysterol binding protein	0.0037	0.0125	0.0322
Echinococcus granulosus	serine/threonine protein kinase	0.0043	0.0157	0.0151
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0102	0.0501	1
Loa Loa (eye worm)	Plekhf2 protein	0.0037	0.0125	0.0125
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1739	1	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0037	0.0125	0.0125
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0686	0.3887	0.3887
Schistosoma mansoni	growth factor receptor-bound protein	0.0037	0.0125	0.012
Schistosoma mansoni	regulator of G protein signaling	0.0225	0.1215	0.121
Loa Loa (eye worm)	uncoordinated protein 104	0.0037	0.0125	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Onchocerca volvulus		0.003	0.0082	0.0023
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0686	0.3887	1
Entamoeba histolytica	PH domain containing protein	0.0037	0.0125	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Onchocerca volvulus		0.0102	0.0501	0.3282
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0102	0.0501	0.3695
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0037	0.0125	0.012
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0076	0.0351	0.6617
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0351
Echinococcus granulosus	axis inhibition protein axin	0.0225	0.1215	0.121
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0037	0.0125	0.2497
Toxoplasma gondii	Oxysterol-binding protein	0.0037	0.0125	0.7052
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0082	0.0546
Brugia malayi	PH domain containing protein	0.0037	0.0125	0.0322
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Schistosoma mansoni	vav2	0.0037	0.0125	0.012
Schistosoma mansoni	goodpasture antigen-binding protein	0.0037	0.0125	0.012
Echinococcus granulosus	pdz domain containing protein	0.0037	0.0125	0.012
Entamoeba histolytica	acyl-coA synthetase, putative	0.0102	0.0501	0.3695
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0037	0.0125	0.0379
Brugia malayi	Dynamin	0.0037	0.0125	0.0322
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0102	0.0501	0.3695
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0037	0.0125	0.0335
Echinococcus multilocularis	regulator of G protein signaling 3	0.0225	0.1215	0.121
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0037	0.0125	0.0358
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0037	0.0125	0.0379
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0043	0.0157	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.012
Echinococcus granulosus	regulator of G protein signaling 3	0.0225	0.1215	0.121
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0351
Brugia malayi	AMP-binding enzyme family protein	0.0102	0.0501	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0351
Toxoplasma gondii	propionate-CoA ligase	0.003	0.0082	0.3023
Echinococcus granulosus	lamin dm0	0.0029	0.0079	0.0074
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Echinococcus granulosus	Oxysterol binding protein 11	0.0037	0.0125	0.012
Brugia malayi	TBC domain containing protein	0.0037	0.0125	0.0322
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Brugia malayi	hypothetical protein	0.0225	0.1215	0.3126
Schistosoma mansoni	regulator of G protein signaling	0.0225	0.1215	0.121
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Echinococcus granulosus	oxysterol binding protein 1	0.0037	0.0125	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Entamoeba histolytica	hypothetical protein	0.0225	0.1215	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0092	0.3909
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0102	0.0501	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0157	0.0657
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0037	0.0125	0.012
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0157	0.0657
Schistosoma mansoni	centaurin alpha	0.0037	0.0125	0.012
Loa Loa (eye worm)	PH domain-containing protein	0.0037	0.0125	0.0125
Echinococcus multilocularis	regulator of G protein signaling 3	0.0225	0.1215	0.121
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.003	0.0082	0.0546
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0215	0.0215
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0327	0.6071
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Onchocerca volvulus		0.0037	0.0125	0.0358
Echinococcus multilocularis	lamin	0.0029	0.0079	0.0074
Schistosoma mansoni	regulator of G protein signaling	0.0225	0.1215	0.121
Echinococcus granulosus	Regulator of G protein signaling 20	0.0225	0.1215	0.121
Echinococcus multilocularis	pdz domain containing protein	0.0037	0.0125	0.012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0501	0.0501
Schistosoma mansoni	dynamin	0.0037	0.0125	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Leishmania major	acetyl-CoA synthetase, putative	0.003	0.0082	0.0715
Echinococcus granulosus	oxysterol binding protein 9	0.0037	0.0125	0.012
Echinococcus granulosus	myotubularin protein 13	0.0037	0.0125	0.012
Trichomonas vaginalis	centaurin alpha, putative	0.0037	0.0125	0.0335
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.046	0.2581	0.6639
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0076	0.0351	0.6421
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0043	0.0157	1
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Brugia malayi	PXA domain containing protein	0.0225	0.1215	0.3126
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0225	0.1215	0.121
Brugia malayi	hypothetical protein	0.0225	0.1215	0.3126
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0037	0.0125	0.0322
Trypanosoma cruzi	Protein kinase B	0.0043	0.0157	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0092	0.0087
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0037	0.0125	0.012
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.003	0.0082	0.3023
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0043	0.0157	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0043	0.0157	1
Echinococcus multilocularis	cytohesin 1	0.0037	0.0125	0.012
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.003	0.0082	0.0546
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.003	0.0082	0.0212
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0043	0.0157	1
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0125	0.0335
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0225	0.1215	0.121
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0037	0.0125	0.0379
Schistosoma mansoni	z-protein (S1r protein)	0.0225	0.1215	0.121
Loa Loa (eye worm)	cytohesin 3	0.0037	0.0125	0.0125
Echinococcus granulosus	Pleckstrin y	0.0037	0.0125	0.012
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0157	0.0403
Onchocerca volvulus		0.0037	0.0125	0.0358
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0322
Onchocerca volvulus		0.0032	0.0092	0.0097
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0037	0.0125	0.2497
Trichomonas vaginalis	centaurin/arf, putative	0.0037	0.0125	0.0335
Schistosoma mansoni	serine/threonine-protein kinase	0.0043	0.0157	0.0151
Trichomonas vaginalis	kinesin light chain, putative	0.0037	0.0125	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Loa Loa (eye worm)	PXA domain-containing protein	0.0225	0.1215	0.1215
Leishmania major	hypothetical protein, conserved	0.0037	0.0125	0.1667
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0079	0.0079
Echinococcus multilocularis	musashi	0.0029	0.0079	0.0074
Schistosoma mansoni	oxysterol-binding protein 1	0.0037	0.0125	0.012
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.003	0.0082	0.0212
Brugia malayi	A-kinase anchor protein 10, precursor	0.0225	0.1215	0.3126
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Leishmania major	protein kinase, putative	0.0043	0.0157	0.2365
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.046	0.2581	0.2577
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0037	0.0125	0.012
Leishmania major	acetyl-CoA synthetase, putative	0.003	0.0082	0.0715
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0157	0.0657
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Entamoeba histolytica	protein kinase, putative	0.0043	0.0157	0.0657
Entamoeba histolytica	p21-activated kinase	0.0043	0.0157	0.0657
Schistosoma mansoni	regulator of G protein signaling	0.0225	0.1215	0.121
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.003	0.0082	0.3023
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0005	0.0005
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0043	0.0157	0.058
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0037	0.0125	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0092	0.0092
Schistosoma mansoni	rho gtpase activating protein	0.0037	0.0125	0.012
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0157	0.058
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0225	0.1215	0.121
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma cruzi	NIMA-related kinase, putative	0.0043	0.0157	1
Schistosoma mansoni	zinc finger protein	0.0037	0.0125	0.012
Echinococcus granulosus	cytohesin 1	0.0037	0.0125	0.012
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0037	0.0125	0.0379
Onchocerca volvulus	Protein melted homolog	0.0037	0.0125	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0225	0.1215	0.884
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0076	0.0076
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0215	0.0552

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (ADMET)	= 30 %	Toxicity in Oryza sativa (rice) plant assessed as inhibition at 150 g/hectare	ChEMBL.	22816730

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2229703

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1799874