Detailed information for compound 209658

Basic information

Technical information
  • TDR Targets ID: 209658
  • Name: 1-hydroxy-1-[[6-[[4-(trifluoromethyl)phenyl]m ethoxy]-2H-chromen-3-yl]methyl]urea
  • MW: 394.344 | Formula: C19H17F3N2O4
  • H donors: 2 H acceptors: 2 LogP: 2.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)N(CC1=Cc2c(OC1)ccc(c2)OCc1ccc(cc1)C(F)(F)F)O
  • InChi: 1S/C19H17F3N2O4/c20-19(21,22)15-3-1-12(2-4-15)10-27-16-5-6-17-14(8-16)7-13(11-28-17)9-24(26)18(23)25/h1-8,26H,9-11H2,(H2,23,25)
  • InChiKey: IGMADJRUJCQGKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-hydroxy-1-[[6-[[4-(trifluoromethyl)phenyl]methoxy]-2H-1-benzopyran-3-yl]methyl]urea
  • 1-hydroxy-1-[[6-[4-(trifluoromethyl)benzyl]oxy-2H-chromen-3-yl]methyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0024 0.0041 0.0638
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.002 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0024 0.0041 0.0638
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Echinococcus granulosus orexin receptor type 2 0.0018 0.002 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.033 0.7767
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0041 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0039 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0007
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0024 0.0041 0.0638
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0024 0.002
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0093 0.0086
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0024 0.0041 0.0638
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.033 0.7767
Echinococcus granulosus g protein coupled receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.2963 1 1
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0039 0.2282
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0022 0.0007
Brugia malayi G-protein coupled receptor 0.0018 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0005
Schistosoma mansoni amine GPCR 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0024 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Leishmania major cytochrome p450-like protein 0.0024 0.0041 0.0026
Echinococcus multilocularis 0.0024 0.0041 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0024 0.0041 0.0638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0019
Echinococcus granulosus fmrfamide receptor 0.0018 0.002 0.0005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0024 0.001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.002 0.0005
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2683 0.9051 1
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0005
Brugia malayi Melatonin receptor type 1A 0.0018 0.002 0.002
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0039 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0022 1
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.002 0.0005
Schistosoma mansoni glycogen phosphorylase 0.0315 0.1027 0.112
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.002 0.0005
Schistosoma mansoni vesicular acetylcholine transporter 0.2683 0.9051 1
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.002 0.0005
Schistosoma mansoni cytochrome P450 0.0024 0.0041 0.0029
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.1515 0.5091 0.5083
Onchocerca volvulus 0.0234 0.075 0.0809
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0799 0.0799
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.002 0.0005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.002 0.0005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.002 0.0005
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.002 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0061 0.0051
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus granulosus g protein coupled receptor 0.0018 0.002 0.0005
Chlamydia trachomatis glycogen phosphorylase 0.0315 0.1027 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0039 0.0027
Brugia malayi neuropeptide F receptor 0.0018 0.002 0.002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.7518
Echinococcus granulosus hypothetical protein 0.0018 0.002 0.0005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0093 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0024 0.0041 0.0638
Echinococcus granulosus tm gpcr rhodopsin 0.1042 0.3489 0.3844
Brugia malayi Serotonin receptor 0.0018 0.002 0.002
Schistosoma mansoni opsin-like receptor 0.0018 0.002 0.0005
Schistosoma mansoni neuropeptide receptor 0.0018 0.002 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Entamoeba histolytica glycogenphosphorylase, putative 0.0136 0.042 0.3963
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0061 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Echinococcus multilocularis Glycosyl transferase, family 35 0.0315 0.1027 0.112
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0675 0.066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0061 0.0051
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0093 0.077
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0024 0.0041 0.2968
Echinococcus multilocularis glycogen phosphorylase 0.0315 0.1027 0.112
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0093 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0024 0.0041 0.0638
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0022 0.01
Echinococcus multilocularis vesicular acetylcholine transporter 0.2683 0.9051 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0093 0.0093
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0024 0.0041 0.0638
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0041 0.0026
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.033 0.7767
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0024 0.0017
Brugia malayi Cytochrome P450 family protein 0.0033 0.007 0.007
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.002 0.0005
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0039 0.2791
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0093 0.0086
Echinococcus granulosus vesicular acetylcholine transporter 0.2683 0.9051 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0015 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.002 0.0004
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0024 0.0041 0.0037
Schistosoma mansoni neuropeptide receptor 0.0018 0.002 0.0005
Brugia malayi G protein-coupled receptor 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) norepinephrine transporter 0.0234 0.075 0.0735
Entamoeba histolytica glycogen phosphorylase, putative 0.0315 0.1027 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0121 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0015 0.066
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.002 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0799 0.0784
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Toxoplasma gondii thioredoxin reductase 0.0048 0.0121 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0093 0.0086
Schistosoma mansoni biogenic amine receptor 0.0018 0.002 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0022 0.0007
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.002 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0008
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.002 0.0005
Plasmodium vivax amine transporter, putative 0.004 0.0093 0.7505
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0024 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0018 0.002 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0122 0.0122
Brugia malayi sulfakinin receptor protein 0.0018 0.002 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.002 0.0005
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0024 0.0041 0.0638
Plasmodium falciparum amino acid transporter, putative 0.004 0.0093 0.7329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0024 0.0041 0.0638
Schistosoma mansoni amine GPCR 0.0018 0.002 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.033 0.7767
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Echinococcus multilocularis orexin receptor type 2 0.0018 0.002 0.0005
Echinococcus granulosus g-protein coupled receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0039 0.0023
Schistosoma mansoni hypothetical protein 0.0024 0.0039 0.0027
Brugia malayi glutathione reductase 0.0048 0.0121 0.0121
Brugia malayi GnHR receptor homolog 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0093 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1042 0.3489 0.3844
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.076 0.0824
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0061 0.0051
Echinococcus granulosus bloom syndrome protein 0.0021 0.0031 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Entamoeba histolytica glycogen phosphorylase, putative 0.0315 0.1027 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0015 0.0707
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.002 0.002
Schistosoma mansoni glycogen phosphorylase 0.0315 0.1027 0.112
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0234 0.075 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Trypanosoma brucei cytochrome P450, putative 0.0033 0.007 0.0066
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.002 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.002 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0121 0.0107
Loa Loa (eye worm) solute carrier family 6 member 4 0.0234 0.075 0.0735
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.002 0.0005
Brugia malayi Dopamine receptor 0.0018 0.002 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0121 0.2623
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0024 0.0041 0.0638
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0441 0.0472
Brugia malayi neuropeptide F receptor 0.0018 0.002 0.002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0024 0.0222
Schistosoma mansoni lipoxygenase 0.0142 0.0441 0.0472
Plasmodium vivax SET domain protein, putative 0.003 0.0061 0.473
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0093 0.0086
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0031 0.0157
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0024 0.0041 0.0638
Schistosoma mansoni loxhd1 0.0024 0.0039 0.0027
Plasmodium falciparum thioredoxin reductase 0.0048 0.0121 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0093 0.0086
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.002 0.0004
Echinococcus granulosus geminin 0.0342 0.1116 0.1219
Loa Loa (eye worm) glycogen phosphorylase 0.0315 0.1027 0.1012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.002 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0045
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0008
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0024 0.0041 0.0638
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0024 0.0041 0.0638
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0024 0.0041 0.0638
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0005
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.002 0.0005
Plasmodium vivax hypothetical protein, conserved 0.004 0.0093 0.7505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.002 0.0005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.002 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.033 0.8746
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0024 0.0089
Brugia malayi Thioredoxin reductase 0.0048 0.0121 0.0121
Brugia malayi Cytochrome P450 family protein 0.0024 0.0041 0.0041
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.002 0.0004
Onchocerca volvulus 0.004 0.0093 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.002 0.0005
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.002 0.0005
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.7518
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0024 0.0041 0.0026
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.002 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0058 0.0047
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.002 0.0005
Brugia malayi larval opioid receptor 0.0018 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Trypanosoma brucei C-8 sterol isomerase, putative 0.2963 1 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0024 0.0041 0.0638
Brugia malayi cytochrome P450 0.0024 0.0041 0.0041
Brugia malayi putative neuropeptide receptor 0.0018 0.002 0.002
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0136 0.042 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.007 0.007
Echinococcus multilocularis sex peptide receptor 0.0018 0.002 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0121 1
Giardia lamblia Glycogen phosphorylase 0.0315 0.1027 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0024 0.0009
Plasmodium falciparum transporter, putative 0.004 0.0093 0.7329
Leishmania major trypanothione reductase 0.0048 0.0121 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0024 0.0041 0.0638
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0093 0.0086
Schistosoma mansoni sodium/chloride dependent transporter 0.0234 0.075 0.0814
Echinococcus granulosus dna polymerase eta 0.0019 0.0024 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0061 0.0051
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0093 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0371 0.8789
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.002 0.0005
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0093 0.0086
Echinococcus multilocularis fmrfamide receptor 0.0018 0.002 0.0005
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0024 0.0041 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.002 0.0005
Echinococcus granulosus g protein coupled receptor 0.0018 0.002 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.002 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0371 0.8789
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0015 0.0011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0024 0.001
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0024 0.0041 0.0638
Entamoeba histolytica glycogen phosphorylase, putative 0.0136 0.042 0.3963
Echinococcus multilocularis neuropeptide receptor 0.0018 0.002 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.002
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0093 0.0086
Plasmodium falciparum glutathione reductase 0.0048 0.0121 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0024 0.0041 0.0638
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Schistosoma mansoni rab6-interacting 0.0024 0.0039 0.0027
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0039 0.0027
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.002 0.0005
Echinococcus multilocularis serotonin receptor 0.0018 0.002 0.0005
Echinococcus multilocularis glycogen phosphorylase 0.0315 0.1027 0.112
Brugia malayi hypothetical protein 0.0024 0.0039 0.0039
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.002 0.0005
Brugia malayi Cytochrome P450 family protein 0.0061 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis geminin 0.0342 0.1116 0.1219
Schistosoma mansoni amine GPCR 0.0018 0.002 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0093 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.002 0.0005
Schistosoma mansoni amine GPCR 0.0018 0.002 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.002 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0022 0.0181
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0024 0.0041 0.0638
Echinococcus granulosus allatostatin A receptor 0.0018 0.002 0.0005
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0093 0.0086
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0024 0.0041 0.0638
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0024 0.0009
Schistosoma mansoni survival motor neuron protein 0.0048 0.0122 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Echinococcus granulosus neuropeptide receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.002 0.0004
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0031 0.0157
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.002 0.0005
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0024 0.0041 0.0638
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.002 0.002
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus granulosus somatostatin receptor 0.0018 0.002 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0022
Leishmania major DNA polymerase kappa, putative 0.0019 0.0024 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0015 0.066
Echinococcus multilocularis RUN 0.0024 0.0039 0.0027
Onchocerca volvulus 0.0024 0.0039 0.0021
Brugia malayi Pre-SET motif family protein 0.0211 0.0675 0.0675
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Giardia lamblia DINP protein human, muc B family 0.0019 0.0024 0.0089
Loa Loa (eye worm) hypothetical protein 0.0234 0.075 0.0735
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0022 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Schistosoma mansoni neuropeptide receptor 0.0018 0.002 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0072
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0016 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0241 0.0774 0.7502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.002 0.0004
Onchocerca volvulus 0.0048 0.0122 0.0113
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2683 0.9051 0.905
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0093 0.0086
Brugia malayi Dopamine receptor protein 1 0.0018 0.002 0.002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0024 0.001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.002 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0234 0.075 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Trypanosoma brucei unspecified product 0.0019 0.0024 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.0093
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0136 0.042 1
Echinococcus granulosus Glycosyl transferase family 35 0.0315 0.1027 0.112
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.002 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0024 0.0041 0.0638
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.002 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0024 0.0024
Onchocerca volvulus Glycogen phosphorylase homolog 0.0315 0.1027 0.1115
Treponema pallidum sodium- and chloride- dependent transporter 0.0234 0.075 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.002 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0009
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0024 0.0041 0.0638
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.002 0.0005
Leishmania major C-8 sterol isomerase-like protein 0.2963 1 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0022 0.1347
Trypanosoma brucei trypanothione reductase 0.0048 0.0121 0.0118
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.002 0.0005
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0234 0.075 0.0814
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0024 0.0041 0.0638
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0006
Brugia malayi AKH receptor 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0061 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0166 0.015
Echinococcus granulosus glycogen phosphorylase 0.0315 0.1027 0.112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Schistosoma mansoni hypothetical protein 0.0048 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.0077
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Leishmania major cytochrome p450-like protein 0.0024 0.0041 0.0026
Schistosoma mansoni hypothetical protein 0.0342 0.1116 0.1219
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.002 0.0005
Schistosoma mansoni glycogen phosphorylase 0.0136 0.042 0.0449
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0024 0.0041 0.0638
Toxoplasma gondii hypothetical protein 0.004 0.0093 0.7518
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0093 0.0086
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.007 0.0053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0031 0.0031
Loa Loa (eye worm) CYP4Cod1 0.0033 0.007 0.0053
Loa Loa (eye worm) serotonin transporter b 0.0234 0.075 0.0735
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0024 0.0041 0.0638
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0024 0.0222
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.002 0.0005
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0024 0.0041 0.0638
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.002 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0024 0.0041 0.0638
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Mycobacterium tuberculosis Probable reductase 0.011 0.033 0.7767
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0024 0.0041 0.0638
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Schistosoma mansoni amine GPCR 0.0018 0.002 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.002 0.0005
Leishmania major cytochrome p450-like protein 0.0033 0.007 0.0055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.002 0.0004
Echinococcus granulosus sex peptide receptor 0.0018 0.002 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0024 0.0024
Schistosoma mansoni biogenic amine receptor 0.0018 0.002 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0005
Schistosoma mansoni adenoreceptor 0.0018 0.002 0.0005
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.002 0.0005
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0008
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0093 0.0086
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0031 0.0018
Brugia malayi Serotonin receptor 0.0018 0.002 0.002
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0024 0.0041 0.0638
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0061 0.4757
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.002 0.0005
Onchocerca volvulus 0.004 0.0093 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Echinococcus multilocularis serotonin receptor 0.0018 0.002 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0093 0.0086
Brugia malayi Dopamine receptor protein 2 0.0018 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0024 0.0041 0.0029
Toxoplasma gondii hypothetical protein 0.004 0.0093 0.7518
Brugia malayi Doublecortin family protein 0.0024 0.0039 0.0039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.002 0.0005
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0093 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0024 0.0041 0.0638
Schistosoma mansoni hypothetical protein 0.0342 0.1116 0.1219
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0024 0.0041 0.0638
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0024 0.0041 0.0638
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.002 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.002 0.0005
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0039 0.0027
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0441 0.0472
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0077
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.002 0.0005
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0024 0.0041 0.0638
Echinococcus multilocularis dna polymerase eta 0.0019 0.0024 0.001
Trichomonas vaginalis glycogen phosphorylase, putative 0.0315 0.1027 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.002 0.0005
Brugia malayi vesicular acetylcholine transporter unc-17 0.2683 0.9051 0.9051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0023
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Schistosoma mansoni biogenic amine receptor 0.0018 0.002 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Schistosoma mansoni myosin xvIII 0.0018 0.002 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0121 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Onchocerca volvulus 0.0024 0.0039 0.0021
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.002 0.0005
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.002 0.0005
Onchocerca volvulus 0.0241 0.0774 0.0835
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0371 0.8789
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.002 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.1303
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0093 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Brugia malayi G-protein coupled receptor 0.0018 0.002 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.007 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.002 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0688
Schistosoma mansoni lipoxygenase 0.01 0.0296 0.0311
Echinococcus granulosus serotonin receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus granulosus RUN 0.0024 0.0039 0.0027
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.7518
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0234 0.075 0.075
Echinococcus granulosus neuropeptide receptor 0.0018 0.002 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.007 0.0055
Schistosoma mansoni opsin-like receptor 0.0018 0.002 0.0005
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.002 0.002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.0077
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.002 0.0005
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0015 0.0707
Onchocerca volvulus 0.004 0.0093 0.0081
Schistosoma mansoni rab6-interacting 0.0024 0.0039 0.0027
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.007 0.0055
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.002 0.0005
Brugia malayi hypothetical protein 0.004 0.0093 0.0093
Brugia malayi hypothetical protein 0.0236 0.076 0.076
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.002 0.0005
Schistosoma mansoni opsin-like receptor 0.0018 0.002 0.0005
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0236 0.076 0.0745
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0023
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0024 0.0089
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0041 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.002 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.002 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.002 0.0005
Echinococcus granulosus serotonin transporter 0.0234 0.075 0.0814
Brugia malayi hypothetical protein 0.0024 0.0039 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0024 0.0222
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0039 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002
Loa Loa (eye worm) RecQ helicase 0.0021 0.0031 0.0015
Schistosoma mansoni neuropeptide receptor 0.0018 0.002 0.0005
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2963 1 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0136 0.042 0.3963
Echinococcus granulosus glycogen phosphorylase 0.0315 0.1027 0.112
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0024 0.0041 0.0638
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.002 0.0005
Brugia malayi carbohydrate phosphorylase 0.0315 0.1027 0.1027
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.076 0.0824
Echinococcus multilocularis somatostatin receptor 0.0018 0.002 0.0005
Loa Loa (eye worm) glutathione reductase 0.0048 0.0121 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.007 0.1346
Echinococcus multilocularis g protein coupled receptor 0.0018 0.002 0.0005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.002 0.0005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0024 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0022 0.0181
Echinococcus granulosus dna polymerase kappa 0.0019 0.0024 0.001
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0024 0.0041 0.0638
Schistosoma mansoni DNA polymerase eta 0.0019 0.0024 0.001
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0024 0.0041 0.0638
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0024 0.001
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.002 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.002 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0121 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0004
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.002 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0024 0.0041 0.0638
Echinococcus multilocularis allatostatin A receptor 0.0018 0.002 0.0005
Onchocerca volvulus 0.003 0.0061 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.002 0.0005
Schistosoma mansoni polycystin 1-related 0.0024 0.0039 0.0027
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0093 0.0086
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0093 0.0093
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0022 0.0669
Brugia malayi ORL1-like opioid receptor 0.0018 0.002 0.002
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0121 0.0118
Brugia malayi RE15519p 0.0018 0.002 0.002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0371 1
Loa Loa (eye worm) cytochrome P450 0.0024 0.0041 0.0025
Trichomonas vaginalis glycogen phosphorylase, putative 0.0315 0.1027 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0024 0.0041 0.0638
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0024 0.0222
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.033 0.7767
Brugia malayi Pre-SET motif family protein 0.003 0.0061 0.0061
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.002 0.0005
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0093 0.0086
Echinococcus granulosus neuropeptide s receptor 0.0018 0.002 0.0005
Echinococcus multilocularis serotonin transporter 0.0234 0.075 0.0814
Schistosoma mansoni histamine h1 receptor 0.0018 0.002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.002

Activities

Activity type Activity value Assay description Source Reference
Duration (functional) = 3 hr Duration of action where maximum inhibition of LTB4 formation is achieved at 1 mg/kg iv ChEMBL. 8246226
Duration (functional) = 3 hr Duration of action where maximum inhibition of LTB4 formation is achieved at 1 mg/kg iv ChEMBL. 8246226
Duration (functional) > 6 hr Duration of action where maximum inhibition of LTB4 formation is achieved at 10 mg/kg po ChEMBL. 8246226
Duration (functional) > 6 hr Duration of action where maximum inhibition of LTB4 formation is achieved at 10 mg/kg po ChEMBL. 8246226
IC50 (binding) = 0.43 uM In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear leukocytes (PMNs). ChEMBL. 8246226
IC50 (binding) = 0.43 uM In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear leukocytes (PMNs). ChEMBL. 8246226
IC50 (binding) = 0.49 uM In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs). ChEMBL. 8246226
IC50 (binding) = 0.49 uM In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs). ChEMBL. 8246226
Inhibition (functional) = 82 % Ex vivo inhibition of LTB-4 determined by measurement of A-23,187-stimulated LTB-4 production in dog blood at 1 mg/kg iv ChEMBL. 8246226
Inhibition (functional) = 82 % Ex vivo inhibition of LTB-4 determined by measurement of A-23,187-stimulated LTB-4 production in dog blood at 1 mg/kg iv ChEMBL. 8246226
Inhibition (functional) > 95 % Ex vivo inhibition of LTB-4 determined by measurement of A-23,187-stimulated LTB-4 production in dog blood at 10 mg/kg po ChEMBL. 8246226
Inhibition (functional) > 95 % Ex vivo inhibition of LTB-4 determined by measurement of A-23,187-stimulated LTB-4 production in dog blood at 10 mg/kg po ChEMBL. 8246226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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