Detailed information for compound 221128

Basic information

Technical information
  • TDR Targets ID: 221128
  • Name: 4-[3-[4-(piperidin-1-ylmethyl)phenoxy]propyl] morpholine
  • MW: 318.454 | Formula: C19H30N2O2
  • H donors: 0 H acceptors: 0 LogP: 2.59 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)Cc1ccc(cc1)OCCCN1CCOCC1
  • InChi: 1S/C19H30N2O2/c1-2-9-21(10-3-1)17-18-5-7-19(8-6-18)23-14-4-11-20-12-15-22-16-13-20/h5-8H,1-4,9-17H2
  • InChiKey: KUIIIXUFHYLJSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[3-[4-(1-piperidylmethyl)phenoxy]propyl]morpholine
  • 4-[3-[4-(piperidinomethyl)phenoxy]propyl]morpholine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0014 0.0033 0.0019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0112 0.014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0242 0.4736 0.5298
Plasmodium vivax SET domain protein, putative 0.0033 0.0429 0.0429
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0865 0.1708
Schistosoma mansoni loxhd1 0.0022 0.0187 0.0209
Mycobacterium tuberculosis Probable reductase 0.0118 0.2169 0.4542
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.2169 0.4542
Loa Loa (eye worm) glutathione reductase 0.0052 0.0807 0.1594
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0016 0.0079 0.012
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0014 0.0033 0.0019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.244 0.5117
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0076 0.1306 0.1958
Leishmania major trypanothione reductase 0.0052 0.0807 0.1198
Entamoeba histolytica P-glycoprotein 6, putative 0.0076 0.1306 0.2757
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.1306 0.146
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0242 0.4736 0.7208
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0016 0.0079 0.0088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0242 0.4736 0.9316
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0014 0.0033 0.0033
Schistosoma mansoni cpg binding protein 0.0033 0.0426 0.0477
Trypanosoma cruzi cAMP response protein 1, putative 0.0014 0.0033 0.0019
Plasmodium falciparum ABC transporter B family member 7, putative 0.0076 0.1306 0.1306
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.1765 0.1973
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0099 0.1789 0.3518
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.078 0.0872
Echinococcus granulosus multidrug resistance protein 1 0.0242 0.4736 0.5298
Schistosoma mansoni multidrug resistance protein 0.0076 0.1306 0.146
Schistosoma mansoni rab6-interacting 0.0022 0.0187 0.0209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0147 0.0288
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0084 0.0096
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0283 0.04
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0076 0.1306 1
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.1467 0.596
Trichomonas vaginalis ABC transporter, putative 0.0242 0.4736 0.9316
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0076 0.1306 0.2706
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0084 0.0127
Mycobacterium ulcerans hypothetical protein 0.0014 0.0033 0.0099
Leishmania major cyclic nucleotide-binding protein-like protein 0.0014 0.0033 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.1467 0.2899
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0076 0.1306 0.39
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0429 0.048
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0033 0.0037
Brugia malayi hypothetical protein 0.0016 0.0084 0.0165
Loa Loa (eye worm) hypothetical protein 0.0076 0.1306 0.258
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0014 0.0033 0.0037
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0266 0.0298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0865 0.1708
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0014 0.0033 0.0037
Echinococcus multilocularis GPCR, family 2 0.0017 0.0099 0.011
Onchocerca volvulus 0.0016 0.0084 0.0164
Brugia malayi ABC transporter 0.0073 0.1251 0.2472
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0469 0.0524
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0014 0.0033 0.0019
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0076 0.1306 0.39
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Echinococcus granulosus ATP binding cassette sub family B 0.0076 0.1306 0.146
Toxoplasma gondii sugar transporter ST3 0.0016 0.0084 0.0127
Leishmania major protein kinase A regulatory subunit, putative 0.0014 0.0033 0.0019
Trypanosoma brucei protein kinase A regulatory subunit 0.0014 0.0033 0.0019
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0093
Echinococcus multilocularis RUN 0.0022 0.0187 0.0209
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.011
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0197 0.0387
Mycobacterium ulcerans endonuclease IV 0.0084 0.1467 0.4382
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0014 0.0033 0.0037
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.2982 0.4511
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0438 0.049
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0014 0.0033 0.0037
Entamoeba histolytica P-glycoprotein 5, putative 0.0073 0.1251 0.2642
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0014 0.0033 0.0037
Onchocerca volvulus 0.0016 0.0084 0.0164
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0266 0.0526
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Echinococcus multilocularis General substrate transporter 0.0101 0.1821 0.2036
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0084 0.0164
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0112 0.0623
Mycobacterium ulcerans hypothetical protein 0.0014 0.0033 0.0099
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0283 0.104
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.4952 0.9785
Plasmodium falciparum multidrug resistance protein 1 0.0242 0.4736 0.4736
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0037 0.0073
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0073 0.1251 0.9572
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0037 0.0041
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0493 0.072
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0266 0.0298
Schistosoma mansoni multidrug resistance protein 0.0076 0.1306 0.146
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0283 0.0317
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0076 0.1306 0.1958
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0187 0.0209
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0099 0.0194
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0266 0.0298
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1306 0.1987
Echinococcus granulosus multidrug resistance protein 1 0.0169 0.3229 0.3611
Plasmodium falciparum multidrug resistance protein 2 0.0076 0.1306 0.1306
Loa Loa (eye worm) multidrug resistance protein 3 0.0242 0.4736 0.9359
Plasmodium falciparum multidrug resistance-associated protein 2 0.0076 0.1306 0.1306
Onchocerca volvulus 0.0111 0.2021 0.3975
Trypanosoma brucei trypanothione reductase 0.0052 0.0807 0.1198
Plasmodium falciparum ABC transporter B family member 3, putative 0.0076 0.1306 0.1306
Loa Loa (eye worm) hypothetical protein 0.0097 0.1733 0.3424
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0014 0.0033 0.0064
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0807 0.0902
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.1306 0.2757
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0014 0.0033 0.005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.6587 1
Schistosoma mansoni hypothetical protein 0.0446 0.8941 1
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.039 0.0769
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0589 0.0866
Plasmodium falciparum ABC transporter B family member 4, putative 0.0076 0.1306 0.1306
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Brugia malayi ABC transporter family protein 0.0076 0.1306 0.258
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0076 0.1306 0.1306
Plasmodium vivax multidrug resistance protein 1, putative 0.0242 0.4736 0.4736
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0266 0.0298
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0187 0.0369
Plasmodium falciparum glutathione reductase 0.0052 0.0807 0.0807
Brugia malayi SET domain containing protein 0.0014 0.0039 0.0077
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0017 0.0087 0.0116
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0084 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0242 0.4736 0.7208
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0283 0.1966
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.2982 0.4511
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0469 0.3424
Treponema pallidum cyclic nucleotide binding protein 0.0014 0.0033 0.2936
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0111 0.2022 0.2262
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0147 0.0288
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0084 0.0093
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0283 0.0431
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0369
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0468 0.0523
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0042 0.0081
Trypanosoma brucei multidrug resistance protein E 0.0076 0.1306 0.1958
Entamoeba histolytica P-glycoprotein 6, putative 0.0076 0.1306 0.2757
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0242 0.4736 0.9316
Plasmodium falciparum hexose transporter 0.0117 0.216 0.216
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0025 0.0266 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0266 0.0526
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0242 0.4736 0.9316
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0187 0.0209
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1306 0.1987
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0028
Trypanosoma brucei cAMP binding protein, putative 0.0014 0.0033 0.0019
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0076 0.1306 0.1958
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.002 0.0061
Loa Loa (eye worm) hypothetical protein 0.0111 0.2021 0.3993
Toxoplasma gondii sugar transporter ST2 0.0016 0.0084 0.0127
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0242 0.4736 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0429 0.0848
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0484 0.0956
Trichomonas vaginalis ABC transporter, putative 0.0242 0.4736 0.9316
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0093
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.6587 1
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0084 0.0096
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0589 0.0589
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0014 0.0033 0.0065
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0589 0.0866
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0266 0.0524
Brugia malayi Cyclic-nucleotide gated cation channel 0.0025 0.0266 0.0526
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Plasmodium falciparum cGMP-dependent protein kinase 0.0016 0.0079 0.0079
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0076 0.1306 0.1958
Onchocerca volvulus 0.0014 0.0033 0.0064
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0084 0.0108
Treponema pallidum catabolite gene activator (Crp) 0.0014 0.0033 0.2936
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Echinococcus granulosus multidrug resistance associated protein 7 0.0076 0.1306 0.146
Brugia malayi P-glycoprotein-like protein 0.0076 0.1306 0.258
Leishmania major ABC-thiol transporter 0.0076 0.1306 0.1958
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0807 0.0902
Loa Loa (eye worm) hypothetical protein 0.0073 0.1251 0.2472
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Leishmania major protein kinase, putative 0.0016 0.0079 0.0089
Toxoplasma gondii hypothetical protein 0.0054 0.0848 0.1289
Schistosoma mansoni survival motor neuron protein 0.0053 0.0828 0.0926
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.244 1
Schistosoma mansoni hypothetical protein 0.0103 0.1873 0.2095
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0242 0.4736 0.9316
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Plasmodium vivax glutathione reductase, putative 0.0052 0.0807 0.0807
Trichomonas vaginalis abcb9, putative 0.0242 0.4736 0.9316
Entamoeba histolytica P-glycoprotein-1 0.0242 0.4736 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0112 0.014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.078 0.1541
Schistosoma mansoni multidrug resistance protein 0.0242 0.4736 0.5298
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0468 0.0523
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0589 0.0866
Schistosoma mansoni glucose transport protein 0.0117 0.216 0.2416
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.1306 0.146
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0112 0.0112
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.244 0.5117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0429 0.048
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0014 0.0033 0.0037
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0865 0.1708
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0469 0.0922
Onchocerca volvulus 0.0016 0.0084 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0493 0.097
Echinococcus multilocularis geminin 0.0185 0.3554 0.3975
Giardia lamblia Hexose transporter 0.0016 0.0084 0.0398
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0037 0.0041
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0014 0.0033 0.0065
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0084 0.025
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Echinococcus granulosus geminin 0.0185 0.3554 0.3975
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0093
Echinococcus granulosus multidrug resistance associated protein 1 0.0076 0.1306 0.146
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1306 0.1987
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0484 0.0484
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis set domain proteins, putative 0.0259 0.5084 1
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0283 0.0598
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0014 0.0033 0.0065
Brugia malayi hypothetical protein 0.0016 0.0084 0.0165
Echinococcus granulosus cGMP dependent protein kinase 1 0.0016 0.0079 0.0088
Echinococcus granulosus multidrug resistance protein 1 0.0169 0.3229 0.3611
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0147 0.0288
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0112 0.014
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0084 0.025
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0283 0.0557
Entamoeba histolytica protein kinase, putative 0.0036 0.0484 0.1021
Mycobacterium ulcerans transmembrane transport protein 0.0014 0.0033 0.0099
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0076 0.1306 0.1958
Echinococcus multilocularis multidrug resistance protein 1 0.0242 0.4736 0.5298
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1306 0.1987
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0025 0.0266 0.0298
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0076 0.1306 0.1958
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0084 0.025
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0242 0.4736 0.9316
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0484 0.0706
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0084 0.0096
Entamoeba histolytica hypothetical protein 0.0026 0.0283 0.0597
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0014 0.0033 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0099 0.011
Echinococcus granulosus patatin phospholipase domain containing protein 0.0014 0.0033 0.0037
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0242 0.4736 0.5298
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0189 0.3649 0.3648
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0493 0.097
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0484 0.0484
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0076 0.1306 0.39
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0037 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.002 0.004
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.1765 0.1973
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0992 0.1509
Giardia lamblia Hypothetical protein 0.0073 0.1251 0.9572
Brugia malayi Doublecortin family protein 0.0022 0.0187 0.0369
Plasmodium falciparum thioredoxin reductase 0.0052 0.0807 0.0807
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Onchocerca volvulus 0.0111 0.2021 0.3975
Onchocerca volvulus 0.0016 0.0084 0.0164
Toxoplasma gondii ABC transporter family protein 0.0076 0.1306 0.1987
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.078 0.1541
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Brugia malayi Cytochrome P450 family protein 0.0013 0.002 0.004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0429 0.0653
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.6587 1
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0076 0.1306 0.1958
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Brugia malayi hypothetical protein 0.0022 0.0187 0.0369
Brugia malayi hypothetical protein 0.0076 0.1306 0.258
Leishmania major p-glycoprotein 0.0242 0.4736 0.7182
Plasmodium falciparum thioredoxin reductase 0.0018 0.0112 0.0112
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.4438 0.8768
Plasmodium vivax ABC transporter B family member 6, putative 0.0076 0.1306 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0079 0.0154
Entamoeba histolytica P-glycoprotein-2 0.0242 0.4736 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0429 0.048
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0076 0.1306 0.1958
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0242 0.4736 0.5298
Trypanosoma brucei sugar transporter, putative 0.0016 0.0084 0.0096
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.216 0.2416
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0033 0.0064
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0112 0.0125
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0084 0.0083
Onchocerca volvulus 0.0016 0.0084 0.0164
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0025 0.0266 0.0298
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0112 0.0169
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0484 0.0737
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0084 0.0165
Loa Loa (eye worm) hypothetical protein 0.0151 0.2858 0.5648
Entamoeba histolytica P-glycoprotein-2 0.0242 0.4736 1
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0151 0.2858 0.5648
Loa Loa (eye worm) hypothetical protein 0.024 0.4682 0.9252
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0084 0.0164
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0493 0.072
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0073 0.1251 0.2461
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0493 0.072
Schistosoma mansoni polycystin 1-related 0.0022 0.0187 0.0209
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1306 0.1987
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0469 0.0524
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0035 0.0468 0.0923
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.2169 0.4542
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0202 0.0702
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0197 0.0589
Echinococcus multilocularis sodium channel protein 0.0074 0.1271 0.1421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0073 0.1251 0.2461
Leishmania major hypothetical protein, conserved 0.0016 0.0084 0.0096
Treponema pallidum cyclic nucleotide binding protein 0.0014 0.0033 0.2936
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0242 0.4736 0.9316
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0033 0.0037
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0014 0.0033 0.005
Onchocerca volvulus 0.0016 0.0084 0.0164
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0589 0.0866
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0429 0.048
Loa Loa (eye worm) sugar transporter 0.0016 0.0084 0.0165
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0706 0.1044
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.244 0.5117
Plasmodium vivax ABC transporter B family member 4, putative 0.0076 0.1306 0.1306
Onchocerca volvulus 0.0242 0.4736 0.9316
Entamoeba histolytica P-glyco protein 6, putative 0.0242 0.4736 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0014 0.0033 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0033 0.0037
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0016 0.0079 0.0088
Brugia malayi ABC transporter 0.0076 0.1306 0.258
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0217 0.0426
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0111 0.2021 0.3993
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0014 0.0033 0.007
Echinococcus granulosus multidrug resistance protein 1 0.0242 0.4736 0.5298
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0112 0.022
Giardia lamblia ABC transporter, putative 0.0076 0.1306 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0147 0.0288
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.039 0.0436
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.2021 0.3993
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0084 0.0165
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0112 0.017
Onchocerca volvulus 0.0016 0.0084 0.0164
Brugia malayi Cam kinase protein 1 0.0036 0.0484 0.0956
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.2169 0.4542
Mycobacterium ulcerans transcriptional regulatory protein 0.0014 0.0033 0.0099
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Loa Loa (eye worm) hypothetical protein 0.0242 0.4736 0.9359
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0084 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0493 0.097
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0014 0.0033 0.0037
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0076 0.1306 0.1958
Onchocerca volvulus 0.0053 0.0828 0.1629
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0187 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0084 0.0164
Onchocerca volvulus Putative transporter 0.0016 0.0084 0.0164
Mycobacterium ulcerans sugar transporter 0.0016 0.0084 0.025
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0266 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0084 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0068 0.0133
Onchocerca volvulus 0.0046 0.0686 0.1348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0084 0.0165
Chlamydia trachomatis endonuclease IV 0.0084 0.1467 0.3098
Echinococcus multilocularis multidrug resistance associated protein 1 0.0076 0.1306 0.146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0147 0.0288
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Loa Loa (eye worm) AGC/PKG protein kinase 0.0016 0.0079 0.0156
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0014 0.0033 0.005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0266 0.0298
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0093
Onchocerca volvulus 0.0022 0.0187 0.0368
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0242 0.4736 0.9359
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Echinococcus multilocularis cpg binding protein 0.0033 0.0426 0.0477
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0469 0.0989
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.1306 0.146
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0084 0.0164
Entamoeba histolytica ABC transporter, putative 0.0076 0.1306 0.2757
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.8941 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0014 0.0033 0.0037
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0093
Brugia malayi follicle stimulating hormone receptor 0.0253 0.4952 0.9785
Brugia malayi ABC transporter transmembrane region family protein 0.0076 0.1306 0.258
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0111 0.2022 0.2262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.078 0.0872
Loa Loa (eye worm) hypothetical protein 0.0076 0.1306 0.258
Onchocerca volvulus 0.0016 0.0084 0.0164
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0084 0.0093
Onchocerca volvulus 0.0016 0.0084 0.0164
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0283 0.0283
Schistosoma mansoni cpg binding protein 0.0031 0.039 0.0435
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0099 0.0194
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0112 0.0221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.078 0.0872
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0242 0.4736 0.9316
Entamoeba histolytica P-glycoprotein 5, putative 0.0242 0.4736 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0076 0.1306 0.1987
Onchocerca volvulus 0.0014 0.0033 0.0064
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0014 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0369
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0014 0.0033 0.0033
Brugia malayi Pre-SET motif family protein 0.0228 0.4438 0.8768
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0099 0.011
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0197 0.0682
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0014 0.0033 0.0037
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0076 0.1306 0.258
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0033 0.0037
Trypanosoma brucei glucose transporter 2A 0.0036 0.0493 0.072
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0033 0.0019
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.2169 0.4542
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0807 0.1646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0283 0.0559
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0242 0.4736 0.5298
Echinococcus granulosus ATP binding cassette sub family B 0.0073 0.1251 0.1399
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0187 0.0209
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0093
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0025 0.0266 0.0298
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0112 0.014
Plasmodium falciparum multidrug resistance-associated protein 1 0.0076 0.1306 0.1306
Loa Loa (eye worm) hypothetical protein 0.0076 0.1306 0.258
Leishmania major hypothetical protein, conserved 0.0014 0.0033 0.0019
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Brugia malayi ABC transporter family protein 0.0076 0.1306 0.258
Schistosoma mansoni multidrug resistance protein 0.0073 0.1251 0.1399
Echinococcus multilocularis expressed conserved protein 0.0016 0.0079 0.0088
Trypanosoma brucei cAMP response protein 1, putative 0.0014 0.0033 0.0019
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.1306 0.2757
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0147 0.0288
Entamoeba histolytica hypothetical protein 0.0076 0.1306 0.2757
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.2396 0.2679
Loa Loa (eye worm) ABC transporter 0.0076 0.1306 0.258
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0283 0.0317
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0112 0.017
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0469 0.1811
Leishmania major protein kinase, putative 0.0036 0.0484 0.0706
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0112 0.0234
Trypanosoma cruzi cAMP binding protein, putative 0.0014 0.0033 0.0019
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0076 0.1306 0.146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Trichomonas vaginalis abcb9, putative 0.0242 0.4736 0.9316
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1138 0.1273
Toxoplasma gondii hypothetical protein 0.0151 0.2858 0.4349
Plasmodium vivax ABC transporter B family member 3, putative 0.0076 0.1306 0.1306
Echinococcus granulosus cGMP dependent protein kinase 1 0.0016 0.0079 0.0088
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0283 0.0317
Brugia malayi Sugar transporter family protein 0.0117 0.216 0.4269
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0111 0.2022 0.3996
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.216 0.3287
Leishmania major pentamidine resistance protein 1 0.0076 0.1306 0.1958
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0283 0.0559
Brugia malayi ABC transporter family protein 0.0076 0.1306 0.258
Brugia malayi Sugar transporter family protein 0.0016 0.0084 0.0165
Echinococcus granulosus RUN 0.0022 0.0187 0.0209
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0099 0.0194
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0112 0.022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0493 0.072
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0657
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0074 0.1271 0.1421
Giardia lamblia Multidrug resistance-associated protein 1 0.0073 0.1251 0.9572
Giardia lamblia Multidrug resistance-associated protein 1 0.0076 0.1306 1
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.216 0.4249
Echinococcus granulosus calcium activated potassium channel 0.0014 0.0024 0.0026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0084 0.0165
Echinococcus multilocularis multidrug resistance protein 1 0.0169 0.3229 0.3611
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0493 0.072
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0807 0.1198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0469 0.0926
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0112 0.0336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0468 0.0923
Loa Loa (eye worm) sugar transporter 0.0117 0.216 0.4269
Schistosoma mansoni voltage-gated potassium channel 0.012 0.2223 0.2486
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.011
Schistosoma mansoni hypothetical protein 0.0185 0.3554 0.3975
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0484 0.0737
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0484 0.0956
Loa Loa (eye worm) hypothetical protein 0.0151 0.2858 0.5648
Schistosoma mansoni hypothetical protein 0.0117 0.216 0.2416
Trypanosoma cruzi protein kinase A regulatory subunit 0.0014 0.0033 0.0019
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.0266 0.0298
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0197 0.0389
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0076 0.1306 0.1958
Entamoeba histolytica P-glycoprotein-5 0.0242 0.4736 1
Brugia malayi hypothetical protein 0.0016 0.0084 0.0165
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0112 0.0237
Brugia malayi Sugar transporter family protein 0.0016 0.0084 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0147 0.0288
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0187 0.0187
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0014 0.0033 0.005
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0169 0.3229 0.6351
Brugia malayi ABC transporter transmembrane region family protein 0.0073 0.1251 0.2472
Brugia malayi major facilitator superfamily protein 0.0016 0.0084 0.0165
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0484 0.0484
Schistosoma mansoni cpg binding protein 0.0033 0.0426 0.0477
Schistosoma mansoni multidrug resistance protein 0.0076 0.1306 0.146
Schistosoma mansoni glucose transport protein 0.0117 0.216 0.2416
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0076 0.1306 0.258
Brugia malayi hypothetical protein 0.0111 0.2021 0.3993
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0266 0.0526
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0112 0.0125
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0112 0.0112
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0484 0.0484
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0266 0.0298
Brugia malayi CHD4 protein 0.0014 0.0037 0.0073
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0468 0.0523
Onchocerca volvulus 0.0022 0.0187 0.0368
Trypanosoma brucei glucose transporter 1E 0.0036 0.0493 0.072
Toxoplasma gondii thioredoxin reductase 0.0052 0.0807 0.1228
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0065
Brugia malayi multidrug resistance protein 3 0.0242 0.4736 0.9359
Toxoplasma gondii ABC transporter, putative 0.0076 0.1306 0.1987
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0014 0.0033 0.0037
Mycobacterium ulcerans hypothetical protein 0.0014 0.0033 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0429 0.048
Brugia malayi glutathione reductase 0.0052 0.0807 0.1594
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0468 0.0523
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.078 0.0872
Trichomonas vaginalis taga, putative 0.0242 0.4736 0.9316
Toxoplasma gondii protein kinase, putative 0.0331 0.6571 1
Schistosoma mansoni multidrug resistance protein 0.0242 0.4736 0.5298
Loa Loa (eye worm) hypothetical protein 0.0242 0.4736 0.9359
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0917 0.1365
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0054 0.0865 0.1708
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.0266 0.0298
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0469 0.0524
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.1306 0.2757
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Brugia malayi multidrug resistance related protein 1 0.0076 0.1306 0.258
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0242 0.4736 0.5298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Onchocerca volvulus 0.0031 0.039 0.0766
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0076 0.1306 0.1958
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0076 0.1306 0.1958
Plasmodium vivax sugar transporter, putative 0.0016 0.0084 0.0083
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0484 0.0484
Echinococcus multilocularis multidrug resistance associated protein 7 0.0076 0.1306 0.146
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0589 0.0866
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0112 0.014
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.5061 0.566
Leishmania major hypothetical protein, unknown function 0.0014 0.0033 0.0019
Mycobacterium ulcerans hypothetical protein 0.0022 0.0197 0.0589
Trichomonas vaginalis ABC transporter, putative 0.0242 0.4736 0.9316
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0484 0.0541
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0202 0.0359
Schistosoma mansoni hypothetical protein 0.0185 0.3554 0.3975
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0493 0.072
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.1306 0.146
Schistosoma mansoni protein kinase 0.0036 0.0484 0.0541
Loa Loa (eye worm) hypothetical protein 0.0258 0.5061 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Echinococcus multilocularis Chromobox protein 3 0.0012 0 0.000000073374
Leishmania major glucose transporter, lmgt1 0.0036 0.0493 0.072
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Entamoeba histolytica P-glycoprotein-2, putative 0.0073 0.1251 0.2642
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0484 0.0541
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0111 0.2022 0.3996
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0112 0.0234
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0076 0.1306 0.1958
Treponema pallidum NADH oxidase 0.0018 0.0112 1
Schistosoma mansoni lipoxygenase 0.0129 0.2396 0.2679
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0242 0.4736 0.9316
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.5061 0.566
Schistosoma mansoni 60S ribosomal protein L21 0.0021 0.0178 0.0199
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0807 0.1594
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0079 0.0088
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.3348 0.7048
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0187 0.0187
Echinococcus granulosus Chromobox protein 3 0.0012 0 0.000000073374
Leishmania major p-glycoprotein e 0.0076 0.1306 0.1958
Brugia malayi N-terminal motif family protein 0.0014 0.0033 0.0065
Schistosoma mansoni protein kinase 0.0036 0.0484 0.0541
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.1467 0.1467
Onchocerca volvulus 0.0016 0.0084 0.0164
Loa Loa (eye worm) CYP4Cod1 0.0013 0.002 0.004
Echinococcus granulosus ATP binding cassette sub family B 0.0076 0.1306 0.146
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0014 0.0033 0.0037
Trypanosoma cruzi hexose transporter, putative 0.002 0.0154 0.0203
Loa Loa (eye worm) hypothetical protein 0.0151 0.2858 0.5648
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.012 0.2223 0.2486
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0484 0.0951
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.078 0.0872
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0493 0.097
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0242 0.4736 0.9316
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0084 0.0164
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0076 0.1306 0.2706
Trichomonas vaginalis abcb9, putative 0.0242 0.4736 0.9316
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0084 0.0165
Schistosoma mansoni protein kinase 0.0036 0.0484 0.0541
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0484 0.0484
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0197 0.0349
Echinococcus multilocularis ATP binding cassette sub family B 0.024 0.4682 0.5237
Trypanosoma cruzi hexose transporter 0.0036 0.0493 0.072
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0014 0.0033 0.0037
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0706 0.1044
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.1306 0.2757
Echinococcus granulosus sodium channel protein 0.0074 0.1271 0.1421
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0266 0.0524
Giardia lamblia MRP-like ABC transporter 0.0076 0.1306 1
Echinococcus granulosus multidrug resistance protein 1 0.0242 0.4736 0.5298
Mycobacterium ulcerans hypothetical protein 0.0175 0.3348 1
Brugia malayi hypothetical protein 0.0022 0.0187 0.0369
Mycobacterium ulcerans regulatory protein 0.0014 0.0033 0.0099
Trypanosoma brucei Flagellar Member 6 0.0014 0.0033 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.2982 0.4511
Loa Loa (eye worm) hypothetical protein 0.0022 0.0197 0.0389
Onchocerca volvulus 0.0016 0.0084 0.0164
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0084 0.0096
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1306 0.2568
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0429 0.048
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0076 0.1306 0.1958
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0589 0.0589
Onchocerca volvulus 0.0016 0.0084 0.0164
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0076 0.1306 0.39
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0706 0.1044
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0014 0.0033 0.0064
Echinococcus granulosus cpg binding protein 0.0033 0.0426 0.0477
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.2169 0.8876
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0033 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0099 0.011
Echinococcus multilocularis calcium activated potassium channel 0.0014 0.0024 0.0026
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0493 0.072
Plasmodium vivax CDK-related protein kinase 6, putative 0.0498 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.0266 0.0298
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.1467 0.1467
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0014 0.0033 0.0033
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0074 0.1271 0.1904
Onchocerca volvulus 0.0259 0.5084 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Trypanosoma cruzi multidrug resistance protein E, putative 0.0076 0.1306 0.1958
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0112 0.0112
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0242 0.4736 0.5298
Plasmodium vivax ABC transporter B family member 5, putative 0.0076 0.1306 0.1306
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0589 0.0896
Echinococcus multilocularis 0.0076 0.1306 0.146
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0093
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0093
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0242 0.4736 0.5298
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0079 0.0088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.0266 0.0298
Schistosoma mansoni multidrug resistance protein 0.0076 0.1306 0.146
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0187 0.0209
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0076 0.1306 0.1306
Schistosoma mansoni hypothetical protein 0.0053 0.0828 0.0926
Brugia malayi hypothetical protein 0.0258 0.5061 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0099 0.011
Trypanosoma brucei RNA helicase, putative 0.0103 0.1873 0.2822
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0828 0.1636
Mycobacterium ulcerans hypothetical protein 0.0014 0.0033 0.0099
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0469 0.0524
Loa Loa (eye worm) ABC transporter 0.0076 0.1306 0.258
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.051 0.1007
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0076 0.1306 0.39
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0283 0.0846
Loa Loa (eye worm) hypothetical protein 0.0033 0.0429 0.0848
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0165
Trypanosoma cruzi Flagellar Member 6 0.0014 0.0033 0.0019
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0084 0.0108
Plasmodium vivax ABC transporter B family member 7, putative 0.0076 0.1306 0.1306
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0079 0.0154
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.1765 0.1973
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0093
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0076 0.1306 0.5289
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0076 0.1306 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0084 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0469 0.0926
Leishmania major glucose transporter, lmgt2 0.0036 0.0493 0.072
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0014 0.0033 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0033 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0112 0.014
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0469 0.0926
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0093
Leishmania major protein kinase, putative 0.0016 0.0079 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0189 0.3649 0.5552
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0037
Schistosoma mansoni multidrug resistance protein 0.0076 0.1306 0.146
Schistosoma mansoni glucose transporter 0.0016 0.0084 0.0093
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0073 0.1251 0.1399
Toxoplasma gondii endonuclease IV APN 0.0084 0.1467 0.2233
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0112 0.0336
Treponema pallidum catabolite gene activator 0.0014 0.0033 0.2936
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.024 0.4682 0.5237
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0112 0.014
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0084 0.0096
Loa Loa (eye worm) hypothetical protein 0.0084 0.1467 0.2899
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0283 0.0846
Trypanosoma brucei p-glycoprotein 0.0076 0.1306 0.1958
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0112 0.0125
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0242 0.4736 1
Leishmania major hypothetical protein, conserved 0.0014 0.0033 0.0019
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0076 0.1306 0.5289
Schistosoma mansoni glucose transport protein 0.0117 0.216 0.2416
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0493 0.097
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.011
Plasmodium vivax multidrug resistance protein 2, putative 0.0076 0.1306 0.1306
Trichomonas vaginalis ABC transporter, putative 0.0242 0.4736 0.9316
Onchocerca volvulus 0.0016 0.0084 0.0164
Schistosoma mansoni lipoxygenase 0.009 0.1598 0.1787
Brugia malayi Cytochrome P450 family protein 0.0013 0.002 0.004
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0014 0.0033 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trypanosoma brucei glucose transporter, putative 0.0036 0.0493 0.072
Plasmodium vivax hexose transporter 0.0117 0.216 0.216
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0438 0.049
Brugia malayi Thioredoxin reductase 0.0052 0.0807 0.1594
Brugia malayi Egg laying defective protein 4 0.0016 0.0079 0.0156
Loa Loa (eye worm) ABC transporter 0.0076 0.1306 0.258
Trypanosoma cruzi cAMP response protein 1 0.0014 0.0033 0.0019
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0073 0.1251 0.2461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.6587 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0189 0.3649 0.3648
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0093
Entamoeba histolytica multidrug resistance protein, putative 0.0076 0.1306 0.2757
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0099 0.1789 0.3518
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0112 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0079 0.0088
Leishmania major regulatory subunit of protein kinase a-like protein 0.0014 0.0033 0.0019
Plasmodium falciparum protein kinase 7 0.0331 0.6571 0.6571
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.2169 0.4542
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0014 0.0033 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1251 0.2461
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0484 0.0737
Giardia lamblia Multidrug resistance-associated protein 1 0.0076 0.1306 1
Entamoeba histolytica protein kinase, putative 0.0036 0.0484 0.1021
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0187 0.0209
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.0541
Schistosoma mansoni smdr1 0.0076 0.1306 0.146
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0484 0.0956
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0112 0.014
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0202 0.0359
Loa Loa (eye worm) hypothetical protein 0.0073 0.1251 0.2472
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0484 0.0484
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0112 0.014
Schistosoma mansoni rab6-interacting 0.0022 0.0187 0.0209
Toxoplasma gondii sugar transporter ST1 0.0016 0.0084 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0484 0.0956
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0014 0.0033 0.0065
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.078 0.0872
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0014 0.0033 0.0037
Brugia malayi CXXC zinc finger family protein 0.0031 0.039 0.0769
Echinococcus multilocularis multidrug resistance protein 1 0.0242 0.4736 0.5298
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0469 0.0926
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0283 0.04
Schistosoma mansoni hypothetical protein 0.0022 0.0187 0.0209
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0112 0.014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0706 0.1044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.078 0.0872
Schistosoma mansoni multidrug resistance protein 0.0242 0.4736 0.5298
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0014 0.0033 0.0037
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0283 0.04
Onchocerca volvulus 0.0016 0.0084 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0147 0.0288
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.051 0.1007
Onchocerca volvulus 0.0016 0.0084 0.0164
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.011
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0686 0.0767
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0468 0.0523
Plasmodium falciparum ABC transporter B family member 5, putative 0.0076 0.1306 0.1306
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0076 0.1306 0.1958
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0283 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0084 0.0164
Echinococcus granulosus cGMP dependent protein kinase 0.0016 0.0079 0.0088
Entamoeba histolytica P-glycoprotein-2, putative 0.0242 0.4736 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.216 0.2416
Echinococcus granulosus GPCR family 2 0.0017 0.0099 0.011
Brugia malayi ABC transporter transmembrane region family protein 0.0076 0.1306 0.258
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0178 0.0199
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0014 0.0033 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0493 0.097
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0242 0.4736 0.5298
Brugia malayi major facilitator superfamily protein 0.0016 0.0084 0.0165
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.1467 0.3049
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0025 0.0266 0.0298
Echinococcus granulosus dnaJ subfamily B 0.0446 0.8941 1
Mycobacterium ulcerans epimerase 0.0022 0.0197 0.0589
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1306 0.1987
Leishmania major hypothetical protein, conserved 0.0014 0.0033 0.0019
Brugia malayi ABC transporter family protein 0.0242 0.4736 0.9359
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0468 0.0523
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0493 0.097
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.1765 0.1973
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0084 0.0164
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0033 0.0064
Echinococcus granulosus General substrate transporter 0.0101 0.1821 0.2036
Schistosoma mansoni hypothetical protein 0.0037 0.051 0.057
Onchocerca volvulus 0.0016 0.0084 0.0164
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0112 0.0336
Plasmodium falciparum ABC transporter B family member 6, putative 0.0076 0.1306 0.1306
Schistosoma mansoni smdr2 0.0242 0.4736 0.5298
Leishmania major glucose transporter, lmgt3 0.0036 0.0493 0.072
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.2396 0.2679
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0266 0.0298
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0242 0.4736 0.5298
Giardia lamblia Sugar-proton symporter 0.0016 0.0084 0.0398
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0242 0.4736 0.7182
Plasmodium falciparum glutathione reductase 0.0018 0.0112 0.0112

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -8.64 In vitro binding affinity for human Histamine H3 receptor by displacing N-[3H]-methylhistamine in SK-N-MC cells was determined ChEMBL. 12930154
Log Ki (binding) = 8.64 In vitro binding affinity for human Histamine H3 receptor by displacing N-[3H]-methylhistamine in SK-N-MC cells was determined ChEMBL. 12930154

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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