Detailed information for compound 235837

Basic information

Technical information
  • TDR Targets ID: 235837
  • Name: (3R)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2- yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl) -2-[[2-[[(2S)-2-[[2-(4-sulfooxyphenyl)acetyl] amino]hexanoyl]amino]acetyl]amino]propanoyl]a mino]hexanoyl]-methylamino]-4-oxobutanoic aci d
  • MW: 977.09 | Formula: C47H60N8O13S
  • H donors: 9 H acceptors: 12 LogP: 3.34 Rotable bonds: 34
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCC[C@@H](C(=O)N([C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CC(=O)O)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)CNC(=O)[C@@H](NC(=O)Cc1ccc(cc1)OS(=O)(=O)O)CCCC
  • InChi: 1S/C47H60N8O13S/c1-4-6-16-35(51-40(56)24-30-19-21-32(22-20-30)68-69(65,66)67)44(61)50-28-41(57)52-38(25-31-27-49-34-18-12-11-15-33(31)34)45(62)53-36(17-7-5-2)47(64)55(3)39(26-42(58)59)46(63)54-37(43(48)60)23-29-13-9-8-10-14-29/h8-15,18-22,27,35-39,49H,4-7,16-17,23-26,28H2,1-3H3,(H2,48,60)(H,50,61)(H,51,56)(H,52,57)(H,53,62)(H,54,63)(H,58,59)(H,65,66,67)/t35-,36-,37-,38-,39+/m0/s1
  • InChiKey: UPYRHIUUCMHYRX-GOXAKLKVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3R)-4-[[(1S)-2-amino-1-benzyl-2-oxo-ethyl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[[2-[[(2S)-2-[[2-(4-sulfooxyphenyl)acetyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]hexanoyl]-methyl-amino]-4-oxo-butanoic acid
  • (3R)-4-[[(1S)-2-amino-1-benzyl-2-oxoethyl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-1-oxo-2-[[1-oxo-2-[[(2S)-1-oxo-2-[[1-oxo-2-(4-sulfooxyphenyl)ethyl]amino]hexyl]amino]ethyl]amino]propyl]amino]-1-oxohexyl]-methylamino]-4-oxobutanoic acid
  • (3R)-4-[[(2S)-1-azanyl-1-oxo-3-phenyl-propan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[2-[[(2S)-2-[2-(4-sulfooxyphenyl)ethanoylamino]hexanoyl]amino]ethanoylamino]propanoyl]amino]hexanoyl]-methyl-amino]-4-oxo-butanoic acid
  • (3R)-4-[[(1S)-2-amino-1-benzyl-2-keto-ethyl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[[2-[[(2S)-2-[[2-(4-sulfoxyphenyl)acetyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]hexanoyl]-methyl-amino]-4-keto-butyric acid
  • (3R)-4-[[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[[2-[[(2S)-2-[[2-(4-sulfooxyphenyl)acetyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]hexanoyl]-methyl-amino]-4-oxo-butanoic acid
  • (3R)-4-[[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-1-oxo-2-[[1-oxo-2-[[(2S)-1-oxo-2-[[1-oxo-2-(4-sulfooxyphenyl)ethyl]amino]hexyl]amino]ethyl]amino]propyl]amino]-1-oxohexyl]-methylamino]-4-oxobutanoic acid
  • (3R)-4-[[(1S)-2-amino-1-(benzyl)-2-keto-ethyl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[[2-[[(2S)-2-[[2-(4-sulfoxyphenyl)acetyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]hexanoyl]-methyl-amino]-4-keto-butyric acid
  • (3R)-4-[[(2S)-1-amino-1-oxo-3-phenyl-propan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[2-[[(2S)-2-[2-(4-sulfooxyphenyl)ethanoylamino]hexanoyl]amino]ethanoylamino]propanoyl]amino]hexanoyl]-methyl-amino]-4-oxo-butanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cholecystokinin A receptor Starlite/ChEMBL References
Rattus norvegicus Cholecystokinin B receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Cholecystokinin A receptor   444 aa 374 aa 24.6 %
Echinococcus granulosus rhodopsin orphan GPCR Cholecystokinin A receptor   444 aa 363 aa 19.6 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Cholecystokinin A receptor   444 aa 395 aa 24.6 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Cholecystokinin A receptor   444 aa 379 aa 24.8 %
Echinococcus multilocularis serotonin receptor Cholecystokinin A receptor   444 aa 468 aa 22.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Cholecystokinin A receptor   444 aa 362 aa 28.2 %
Loa Loa (eye worm) hypothetical protein Cholecystokinin B receptor   452 aa 389 aa 31.4 %
Echinococcus multilocularis neuropeptides capa receptor Cholecystokinin A receptor   444 aa 400 aa 21.0 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.5 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Cholecystokinin A receptor   444 aa 383 aa 21.7 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 399 aa 23.3 %
Echinococcus multilocularis orexin receptor type 2 Cholecystokinin A receptor   444 aa 362 aa 22.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cholecystokinin A receptor   444 aa 364 aa 28.6 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 403 aa 24.1 %
Onchocerca volvulus Cholecystokinin A receptor   444 aa 385 aa 28.6 %
Echinococcus granulosus orexin receptor type 2 Cholecystokinin A receptor   444 aa 366 aa 23.5 %
Schistosoma mansoni rhodopsin-like orphan GPCR Cholecystokinin A receptor   444 aa 380 aa 24.2 %
Schistosoma mansoni amine GPCR Cholecystokinin A receptor   444 aa 412 aa 26.2 %
Schistosoma japonicum FMRFamide receptor, putative Cholecystokinin A receptor   444 aa 363 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Brugia malayi beta-lactamase family protein 0.0074 0.0138 0.0394
Brugia malayi hypothetical protein 0.0509 0.1182 0.3379
Echinococcus granulosus methionine synthase reductase 0.0033 0.0038 0.0043
Brugia malayi transcriptional regulator, Sir2 family protein 0.0116 0.0237 0.0677
Mycobacterium ulcerans acetyl-CoA synthetase 0.0037 0.0047 0.0043
Brugia malayi topoisomerase 0.0031 0.0032 0.0092
Mycobacterium tuberculosis Conserved protein 0.0074 0.0138 0.0296
Brugia malayi Patched related family protein 10 0.0019 0.0003 0.001
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0372 0.0852 0.0852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0083 0.0083
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0054 0.0088 0.0244
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0032 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0138 0.0371
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0083 0.0093
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.0047 0.0036
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0037 0.0037
Plasmodium vivax acyl-CoA synthetase, putative 0.0094 0.0184 0.052
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.0047 0.0036
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0066 0.0182
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0032 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0105 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0264 0.0295
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0076 0.021
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0076 0.021
Loa Loa (eye worm) hypothetical protein 0.0074 0.0138 0.0394
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0037 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.026 0.0657
Schistosoma mansoni hypothetical protein 0.0052 0.0083 0.0093
Loa Loa (eye worm) hypothetical protein 0.0094 0.0184 0.0526
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0002 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0037 0.0105
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0105 0.0117
Echinococcus multilocularis geminin 0.0706 0.1655 0.1655
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0047 0.0135
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0138 0.0371
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0372 0.0852 0.2435
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0047 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0083 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0089 0.0172 0.0395
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0032 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0037 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0037 0.0037
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0072 0.008
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0047 0.0036
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.001 0.0011
Toxoplasma gondii patched family protein 0.0019 0.0003 0.0004
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0372 0.0852 0.2365
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0006
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0072 0.0579
Schistosoma mansoni hypothetical protein 0.0077 0.0143 0.016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0087 0.0249
Schistosoma mansoni hypothetical protein 0.0052 0.0083 0.0093
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0105 0.0201
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0037 0.0105
Echinococcus multilocularis protein patched 0.0131 0.0274 0.0274
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0093 0.0261
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0205
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0372 0.0852 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.0047 0.0135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0293 0.0662 0.1892
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1473 0.3498 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0033 0.0038 0.0109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.0662 0.0662
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0142 0.0301 0.0301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0037 0.0105
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0037 0.0284
Brugia malayi Niemann-Pick C1 protein precursor 0.0306 0.0693 0.1982
Plasmodium vivax hypothetical protein, conserved 0.002 0.0008 0.0017
Giardia lamblia Hypothetical protein 0.0116 0.0237 0.0628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0121 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0138 0.0392
Loa Loa (eye worm) patched family protein 0.0019 0.0003 0.001
Loa Loa (eye worm) runx1 0.0064 0.0112 0.0321
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0018 0.0046
Mycobacterium ulcerans hypothetical protein 0.0074 0.0138 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.0565 0.1616
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0002 0.0002
Mycobacterium ulcerans hypothetical protein 0.0125 0.026 0.0657
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0032 0.0069
Trypanosoma cruzi importin beta-1 subunit, putative 0.0054 0.0089 0.0254
Onchocerca volvulus 0.0059 0.01 0.0819
Plasmodium vivax patched family protein, putative 0.0019 0.0003 0.0004
Toxoplasma gondii exonuclease III APE 0.0061 0.0105 0.0293
Brugia malayi Patched related family protein 12 0.0019 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0069
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0054 0.0088 0.0159
Loa Loa (eye worm) hypothetical protein 0.0732 0.1718 0.4911
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0037 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0118 0.0132
Echinococcus granulosus Niemann Pick C1 protein 0.0306 0.0693 0.0776
Onchocerca volvulus 0.0037 0.0047 0.0373
Echinococcus granulosus snurportin 1 0.0716 0.1678 0.1878
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1473 0.3498 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0116 0.0237 0.0675
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0047 0.0135
Mycobacterium leprae Probable lipase LipE 0.0074 0.0138 0.1286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Trypanosoma brucei importin beta-1 subunit, putative 0.0067 0.012 0.0337
Schistosoma mansoni ap endonuclease 0.0061 0.0105 0.0117
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0306 0.0693 0.8121
Onchocerca volvulus 0.0037 0.0047 0.0373
Loa Loa (eye worm) hypothetical protein 0.0141 0.0297 0.0849
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1473 0.3498 1
Onchocerca volvulus 0.0074 0.0138 0.114
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0047 0.0134
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0125 0.026 0.065
Brugia malayi Patched protein homolog 1 0.0019 0.0003 0.001
Trichomonas vaginalis importin beta-1, putative 0.0054 0.0089 0.0233
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0114 0.0127
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0006
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0087 0.0087
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0032 0.0032
Schistosoma mansoni diflavin oxidoreductase 0.0027 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus multilocularis Protein lozenge 0.0064 0.0112 0.0112
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0032 0.0091
Brugia malayi hypothetical protein 0.0019 0.0003 0.001
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0037 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0105 0.0299
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0114 0.0127
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0138 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0037 0.0105
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0037 0.0047 0.0043
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Loa Loa (eye worm) patched family protein 0.0019 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0351 0.1002
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0372 0.0852 0.2431
Loa Loa (eye worm) hypothetical protein 0.0054 0.0088 0.025
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0007 0.0021
Echinococcus granulosus GPCR family 2 0.0052 0.0083 0.0093
Echinococcus multilocularis sterol regulatory element binding protein 0.0131 0.0274 0.0274
Schistosoma mansoni microtubule-associated protein tau 0.3737 0.8939 1
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0006
Treponema pallidum octaprenyl-diphosphate synthase 0.0372 0.0852 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0047 0.0134
Brugia malayi Pre-SET motif family protein 0.0064 0.0114 0.0325
Schistosoma mansoni hypothetical protein 0.0126 0.0263 0.0294
Loa Loa (eye worm) MBCTL1 0.0053 0.0087 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0118 0.0132
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1473 0.3498 0.3498
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0018 0.0052
Brugia malayi Pre-SET motif family protein 0.0441 0.1019 0.2914
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0138 0.0392
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0054 0.0089 0.0233
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Schistosoma mansoni chromatin regulatory protein sir2 0.0116 0.0237 0.0265
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0054 0.0088 0.0249
Leishmania major p450 reductase, putative 0.0054 0.0088 0.0249
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.0318 0.0908
Entamoeba histolytica Ran family GTPase 0.0025 0.0018 0.0119
Leishmania major farnesyl pyrophosphate synthase 0.1473 0.3498 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0037 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1473 0.3498 0.3913
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.0047 0.0053
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0372 0.0852 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0114 0.0127
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0142 0.0301 0.0337
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0002 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0083 0.0237
Onchocerca volvulus 0.0509 0.1182 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.0662 0.074
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0129 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0092
Brugia malayi FAD binding domain containing protein 0.0054 0.0088 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0069
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0138 0.0296
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0087 0.0097
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0087 0.0249
Brugia malayi RNA binding protein 0.0066 0.0118 0.0336
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1473 0.3498 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.002 0.0008 0.0021
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0072 0.0205
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0072 0.0072
Echinococcus multilocularis chromatin regulatory protein sir2 0.0116 0.0237 0.0237
Echinococcus granulosus nibrin 0.0031 0.0032 0.0036
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0125 0.026 0.0657
Echinococcus granulosus expressed conserved protein 0.0287 0.0649 0.0726
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0018 0.0046
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0372 0.0852 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0037 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0105 0.0293
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0033 0.0095
Plasmodium vivax SET domain protein, putative 0.0064 0.0114 0.0319
Brugia malayi CXXC zinc finger family protein 0.0059 0.01 0.0286
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0092
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1473 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.026 0.0744
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0142 0.0301 0.0776
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0076 0.0194
Brugia malayi flavodoxin family protein 0.002 0.0008 0.0023
Brugia malayi hypothetical protein 0.0732 0.1718 0.4911
Echinococcus granulosus tumor protein p63 0.0752 0.1767 0.1977
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0372 0.0852 0.2434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0114 0.0127
Schistosoma mansoni trans-prenyltransferase 0.0372 0.0852 0.0953
Loa Loa (eye worm) hypothetical protein 0.0125 0.026 0.0744
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.0351 0.1002
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0118 0.0336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.002 0.0008 0.0021
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0032 0.0069
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0037 0.0105
Schistosoma mansoni hypothetical protein 0.0025 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0094 0.0184 0.0526
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0037 0.0284
Onchocerca volvulus Huntingtin homolog 0.0141 0.0297 0.2493
Schistosoma mansoni ran 0.0025 0.0018 0.002
Leishmania major hypothetical protein, conserved 0.0018 0.0002 0.0005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0047 0.0134
Trichomonas vaginalis set domain proteins, putative 0.0502 0.1165 0.3316
Entamoeba histolytica hypothetical protein 0.0077 0.0143 0.1602
Echinococcus granulosus Niemann Pick C1 protein 0.0437 0.1008 0.1128
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.0047 0.0053
Schistosoma mansoni cellular tumor antigen P53 0.011 0.0223 0.025
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.002 0.0008 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0118 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus granulosus geminin 0.0706 0.1655 0.1851
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0116 0.0237 0.0675
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0037 0.0105
Loa Loa (eye worm) RNA binding protein 0.0066 0.0118 0.0336
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.0047 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.0984 0.0984
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0047 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0138 0.0304
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0054 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0261 0.0586 0.1677
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0105 0.0297
Trypanosoma cruzi polyprenyl synthase, putative 0.0372 0.0852 0.2434
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0138 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0037 0.0105
Loa Loa (eye worm) hypothetical protein 0.0306 0.0693 0.1982
Brugia malayi mbt repeat family protein 0.0047 0.0072 0.0205
Schistosoma mansoni topbp1 0.0031 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.011 0.0223 0.0639
Schistosoma mansoni hypothetical protein 0.0111 0.0227 0.0253
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0121 0.0136
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0054 0.0088 0.0244
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Schistosoma mansoni chromatin regulatory protein sir2 0.0116 0.0237 0.0265
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0018 0.002
Echinococcus granulosus chromatin regulatory protein sir2 0.0116 0.0237 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0037 0.0105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0083 0.0237
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0114 0.0127
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0047 0.0135
Plasmodium vivax acetyl-CoA synthetase, putative 0.0037 0.0047 0.0129
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1473 0.3498 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0069
Onchocerca volvulus 0.0125 0.026 0.2179
Leishmania major GTP-binding protein, putative 0.0025 0.0018 0.005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0037 0.0284
Loa Loa (eye worm) histone methyltransferase 0.002 0.0008 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0094 0.0184 0.043
Loa Loa (eye worm) hypothetical protein 0.0509 0.1182 0.3379
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0037 0.0037
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0138 0.0296
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0116 0.0237 0.271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0125 0.026 0.065
Toxoplasma gondii propionate-CoA ligase 0.0037 0.0047 0.0129
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.01 0.0286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0037 0.0041
Schistosoma mansoni hypothetical protein 0.0126 0.0263 0.0294
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0116 0.0237 0.0655
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0089 0.0172 0.0395
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0054 0.0088 0.0098
Loa Loa (eye worm) hypothetical protein 0.1293 0.3065 0.8764
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0118 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0047 0.0135
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0002 0.0002
Echinococcus multilocularis snurportin 1 0.0716 0.1678 0.1678
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0105 0.0249
Brugia malayi Polyprenyl synthetase family protein 0.0372 0.0852 0.2435
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.0351 0.1002
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0037 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Brugia malayi ecdysteroid receptor 0.0032 0.0037 0.0105
Giardia lamblia Hypothetical protein 0.0047 0.0073 0.0158
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0019 0.0021
Schistosoma mansoni ap endonuclease 0.0061 0.0105 0.0117
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0037 0.0037
Echinococcus granulosus sterol regulatory element binding protein 0.0131 0.0274 0.0307
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0008 0.0009
Loa Loa (eye worm) patched family protein 0.0019 0.0003 0.001
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0047 0.0129
Schistosoma mansoni hypothetical protein 0.0126 0.0263 0.0294
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0372 0.0852 0.0852
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.002 0.0008 0.0017
Treponema pallidum fructose-bisphosphate aldolase 0.0336 0.0766 0.8981
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1473 0.3498 0.3913
Brugia malayi hypothetical protein 0.0056 0.0093 0.0267
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0072 0.0072
Toxoplasma gondii flavodoxin domain-containing protein 0.0027 0.0023 0.0059
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0372 0.0852 1
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.002 0.0008 0.0017
Echinococcus multilocularis GPCR, family 2 0.0052 0.0083 0.0083
Leishmania major solanesyl-diphosphate synthase, putative 0.0372 0.0852 0.2434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0118 0.0336
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0047 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0018 0.0046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.026 0.2987
Mycobacterium ulcerans aldehyde dehydrogenase 0.0142 0.0301 0.0776
Loa Loa (eye worm) transcriptional regulator 0.0116 0.0237 0.0677
Mycobacterium tuberculosis Conserved protein 0.0074 0.0138 0.0296
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0037 0.0041
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0138 0.0296
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0037 0.0041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0293 0.0662 0.1892
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0037 0.0037
Schistosoma mansoni cpg binding protein 0.0062 0.0108 0.0121
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0087 0.0087
Schistosoma mansoni glutathione synthetase 0.0372 0.0852 0.0953
Schistosoma mansoni survival motor neuron protein 0.0149 0.0318 0.0355
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0118 0.0336
Brugia malayi hypothetical protein 0.0036 0.0046 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0142 0.0301 0.0769
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.0356 0.0356
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0047 0.0036
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0372 0.0852 0.2359
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0372 0.0852 0.0953
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0138 0.0388
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0087 0.0097
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0372 0.0852 0.0953
Brugia malayi hypothetical protein 0.0019 0.0003 0.001
Onchocerca volvulus 0.0037 0.0047 0.0373
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0138 0.0394
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0372 0.0852 0.2431
Echinococcus granulosus cpg binding protein 0.0062 0.0108 0.0121
Echinococcus granulosus Protein patched homolog 1 0.0131 0.0274 0.0307
Mycobacterium tuberculosis Conserved protein 0.0074 0.0138 0.0296
Leishmania major importin beta-1 subunit, putative 0.0054 0.0089 0.0254
Leishmania major silent information regulator 2, putative 0.0116 0.0237 0.0675
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0093 0.0261
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0105 0.0293
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0054 0.0088 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.0662 0.074
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0093 0.0266
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0032 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0336 0.0766 0.8981
Onchocerca volvulus 0.0502 0.1165 0.986
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.0047 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0037 0.0041
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.001 0.001
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0105 0.0277
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Schistosoma mansoni lozenge 0.0064 0.0112 0.0126
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0047 0.0135
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0105 0.0297
Brugia malayi AMP-binding enzyme family protein 0.0125 0.026 0.0744
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0037 0.0047 0.0043
Toxoplasma gondii HEAT repeat-containing protein 0.0067 0.012 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.0662 0.074
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.0353 0.0919
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0047 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0093 0.0261
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0047 0.0036
Brugia malayi steroid hormone receptor 0.0032 0.0037 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0032 0.0091
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0018 0.0046
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0105 0.0277
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0037 0.0041
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.0345 0.0386
Loa Loa (eye worm) hypothetical protein 0.0074 0.0138 0.0394
Loa Loa (eye worm) hypothetical protein 0.0509 0.1182 0.3379
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0032 0.0069
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0372 0.0852 0.2434
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1473 0.3498 1
Schistosoma mansoni hypothetical protein 0.0716 0.1678 0.1878
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.026 0.0742
Schistosoma mansoni patched 1 0.0131 0.0274 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0032 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0125 0.026 0.0657
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0002 0.0005
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0372 0.0852 0.2435
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0002 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0072 0.008
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0372 0.0852 0.0953
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0135
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0241 0.0685
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.0047 0.0036
Leishmania major hypothetical protein, conserved 0.002 0.0008 0.0021
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0372 0.0852 0.2365
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.026 0.0742
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0116 0.0237 0.0655
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0105 0.0117
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0032 0.0287
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0047 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.0351 0.1002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0083 0.0083
Toxoplasma gondii hypothetical protein 0.0019 0.0003 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.3737 0.8939 0.8939
Schistosoma mansoni aldehyde dehydrogenase 0.0142 0.0301 0.0337
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.026 0.278
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.002 0.0008 0.0021
Schistosoma mansoni topbp1 0.0031 0.0032 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0047 0.0135
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0037 0.0047 0.0043
Mycobacterium ulcerans lipase LipD 0.0074 0.0138 0.0304
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0138 0.0304
Toxoplasma gondii patched family protein 0.0019 0.0003 0.0004
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0372 0.0852 0.2431
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0105 0.0297
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0054 0.0088 0.0244
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.0047 0.0129
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.026 0.2987
Brugia malayi mbt repeat family protein 0.0047 0.0072 0.0205
Onchocerca volvulus Huntingtin homolog 0.0141 0.0297 0.2493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0037 0.0105
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.0047 0.0129
Schistosoma mansoni DNA ligase IV 0.0031 0.0032 0.0036
Brugia malayi sulfakinin receptor protein 0.0261 0.0586 0.1677
Echinococcus granulosus survival motor neuron protein 1 0.0732 0.1718 0.1922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.0662 0.074
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0076 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0125 0.026 0.0657
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0076 0.0194
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0094 0.0184 0.1851
Leishmania major polyprenyl synthase, putative 0.0372 0.0852 0.2434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Brugia malayi CHE-14 protein 0.0131 0.0274 0.0783
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0066 0.0686
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0032 0.0086
Loa Loa (eye worm) beta-lactamase 0.0074 0.0138 0.0394
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0054 0.0088 0.0088
Toxoplasma gondii ABC1 family protein 0.0074 0.0138 0.0388
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0105 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0018 0.0052
Brugia malayi nuclear receptor NHR-88 0.0032 0.0037 0.0105
Onchocerca volvulus 0.0031 0.0032 0.0245
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0032 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0037 0.0105
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0002 0.0002
Leishmania major cytochrome P450 reductase, putative 0.0047 0.0073 0.0207
Entamoeba histolytica hypothetical protein 0.0054 0.0089 0.0964
Loa Loa (eye worm) hypothetical protein 0.0131 0.0274 0.0783
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0227 0.0648
Onchocerca volvulus 0.0037 0.0047 0.0373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trypanosoma cruzi polyprenyl synthase, putative 0.0372 0.0852 0.2434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0143 0.0143
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0032 0.0092
Chlamydia trachomatis sulfite reductase 0.0033 0.0038 0.0074
Schistosoma mansoni NADPH flavin oxidoreductase 0.0027 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Leishmania major hypothetical protein, conserved 0.0074 0.0138 0.0392
Echinococcus granulosus importin subunit beta 1 0.0067 0.012 0.0134
Entamoeba histolytica hypothetical protein 0.0077 0.0143 0.1602
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0138 0.0371
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0372 0.0852 0.2359
Trichomonas vaginalis ran, putative 0.0025 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0141 0.0297 0.0849
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.026 0.278
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0116 0.0237 0.0265
Schistosoma mansoni chromatin regulatory protein sir2 0.0116 0.0237 0.0265
Schistosoma mansoni hypothetical protein 0.0706 0.1655 0.1851
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0018 0.005
Schistosoma mansoni coup transcription factor 0.0032 0.0037 0.0041
Giardia lamblia Fructose-bisphosphate aldolase 0.0336 0.0766 0.2149
Loa Loa (eye worm) hypothetical protein 0.0064 0.0114 0.0325
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.0047 0.0465
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0032 0.0041
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0105 0.0299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0092
Mycobacterium ulcerans beta-lactamase 0.0074 0.0138 0.0304
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0716 0.1678 0.4798
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1473 0.3498 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0054 0.0088 0.0249
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0138 0.1286
Onchocerca volvulus 0.0047 0.0072 0.0579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.0662 0.074
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.026 0.0742
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0121 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0089 0.0172 0.0395
Onchocerca volvulus 0.0064 0.0114 0.0935
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0002 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0142 0.0301 0.0856
Brugia malayi AMP-binding enzyme family protein 0.0125 0.026 0.0744
Plasmodium vivax flavodoxin domain containing protein 0.0047 0.0073 0.0202
Loa Loa (eye worm) hypothetical protein 0.0094 0.0184 0.0526
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0032 0.0091
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0142 0.0301 0.086
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1473 0.3498 1
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0143 0.016
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0002 0.0002
Loa Loa (eye worm) FAD binding domain-containing protein 0.0054 0.0088 0.025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0105 0.0209
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0037 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0138 0.0154
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0037 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0074 0.0138 0.0394
Schistosoma mansoni niemann-pick C1 (NPC1) 0.031 0.0705 0.0788
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Echinococcus multilocularis protein dispatched 1 0.015 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0126 0.0263 0.0294
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0105 0.0882
Schistosoma mansoni cpg binding protein 0.0059 0.01 0.0112
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0083 0.0237
Brugia malayi protein C24B5.3 0.0019 0.0003 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0037 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0138 0.0371
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0372 0.0852 0.0852
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0116 0.0237 0.0237
Brugia malayi hypothetical protein 0.0261 0.0586 0.1677
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1473 0.3498 1
Toxoplasma gondii patched family protein 0.0019 0.0003 0.0004
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0037 0.0047 0.0183
Brugia malayi RNA, U transporter 1 0.0191 0.0417 0.1192
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0125 0.026 0.0744
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0093 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0037 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0138 0.0388
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0131 0.0274 0.0783
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0032 0.0091
Loa Loa (eye worm) acetyltransferase 0.0165 0.0356 0.1018
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0032 0.0036
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0072 0.008
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0118 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.026 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0037 0.0105
Onchocerca volvulus 0.0074 0.0138 0.114
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0037 0.0041
Schistosoma mansoni hypothetical protein 0.0427 0.0984 0.1101
Brugia malayi jmjC domain containing protein 0.0071 0.0129 0.037
Loa Loa (eye worm) polyprenyl synthetase 0.1473 0.3498 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0037 0.0041
Echinococcus granulosus tar DNA binding protein 0.0066 0.0118 0.0132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0092
Brugia malayi flavodoxin family protein 0.0054 0.0088 0.025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0138 0.0394
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Brugia malayi Importin beta-1 subunit 0.0067 0.012 0.0343
Echinococcus multilocularis cpg binding protein 0.0062 0.0108 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0037 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0067 0.012 0.0343
Echinococcus multilocularis muscleblind protein 1 0.1293 0.3065 0.3065
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0648
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0138 0.0154
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0032 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Brugia malayi jmjC domain containing protein 0.0068 0.0121 0.0347
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0047 0.0134
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.0047 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0129 0.0145
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0093 0.0261
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0054 0.0088 0.0244
Echinococcus multilocularis survival motor neuron protein 1 0.0732 0.1718 0.1718
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0138 0.0394
Loa Loa (eye worm) patched family protein 0.0019 0.0003 0.001
Trichomonas vaginalis sulfite reductase, putative 0.0054 0.0088 0.0228
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0037 0.0047 0.0043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0125 0.026 0.0657
Brugia malayi beta-lactamase 0.0074 0.0138 0.0394
Echinococcus multilocularis muscleblind protein 0.1293 0.3065 0.3065
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0002 0.0002
Echinococcus multilocularis importin subunit beta 1 0.0067 0.012 0.012
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0105 0.1144
Loa Loa (eye worm) hypothetical protein 0.0161 0.0345 0.0986
Loa Loa (eye worm) polyprenyl synthetase 0.0372 0.0852 0.2435
Schistosoma mansoni hypothetical protein 0.0706 0.1655 0.1851
Echinococcus multilocularis expressed conserved protein 0.0287 0.0649 0.0649
Echinococcus granulosus dnaJ subfamily B 0.0427 0.0984 0.1101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0083 0.0237
Brugia malayi beta-lactamase family protein 0.0074 0.0138 0.0394
Schistosoma mansoni hypothetical protein 0.0052 0.0083 0.0093
Loa Loa (eye worm) hypothetical protein 0.0094 0.0184 0.0526
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Loa Loa (eye worm) oxidoreductase 0.0037 0.0047 0.0135
Loa Loa (eye worm) hypothetical protein 0.0074 0.0138 0.0394
Leishmania major hypothetical protein, conserved 0.0056 0.0093 0.0266
Brugia malayi Cytochrome P450 family protein 0.0031 0.0033 0.0095
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0336 0.0766 0.8981
Plasmodium falciparum importin beta, putative 0.0067 0.012 0.0337
Schistosoma mansoni aldehyde dehydrogenase 0.0142 0.0301 0.0337
Trypanosoma brucei importin beta-1 subunit, putative 0.0067 0.012 0.0337
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.0047 0.0129
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0002 0.0006
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0372 0.0852 0.2431
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.1019 0.2914
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0037 0.0041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0037 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0037 0.0105
Brugia malayi MH2 domain containing protein 0.0252 0.0565 0.1616
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0432 0.0484
Schistosoma mansoni hypothetical protein 0.0052 0.0083 0.0093
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0054 0.0088 0.0249
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0093 0.0261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0125 0.026 0.2987
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0054 0.0088 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0037 0.0105
Echinococcus multilocularis nibrin 0.0031 0.0032 0.0032
Echinococcus granulosus microtubule associated protein 2 0.3737 0.8939 1
Brugia malayi Patched related family protein 4 0.0019 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0074 0.0138 0.0394
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0018 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0054 0.0089 0.0233
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0047 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0008 0.0008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.0353 0.0926
Brugia malayi hypothetical protein 0.0019 0.0003 0.001
Echinococcus multilocularis methionine synthase reductase 0.0033 0.0038 0.0038
Giardia lamblia Nitric oxide synthase, inducible 0.0047 0.0073 0.0158
Trichomonas vaginalis esterase, putative 0.0074 0.0138 0.0371
Brugia malayi AMP-binding enzyme family protein 0.0125 0.026 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0037 0.0105
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.0047 0.0036
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0116 0.0237 0.271
Plasmodium falciparum nitric oxide synthase, putative 0.0054 0.0088 0.0244
Giardia lamblia Farnesyl diphosphate synthase 0.1473 0.3498 1
Loa Loa (eye worm) patched family protein 0.0019 0.0003 0.001
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0002 0.0002
Echinococcus granulosus phd:f box containing protein 0.0018 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0297 0.0674 0.0753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Trypanosoma cruzi p450 reductase, putative 0.0054 0.0088 0.0249
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0114 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0037 0.0105
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0116 0.0237 0.0671
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1473 0.3498 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0143 0.016
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0018 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0114 0.0114
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0114 0.0114
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0076 0.021
Loa Loa (eye worm) hypothetical protein 0.0094 0.0184 0.0526
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0037 0.0047 0.0183
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0372 0.0852 0.2434
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0069
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0372 0.0852 1
Brugia malayi DKFZp564C0469 protein 0.0031 0.0032 0.0092
Echinococcus multilocularis Niemann Pick C1 protein 0.0306 0.0693 0.0693
Onchocerca volvulus 0.011 0.0223 0.1868
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0121 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0142 0.0301 0.0776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0089 0.0172 0.0395
Brugia malayi hypothetical protein 0.0031 0.0032 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0037 0.0041
Brugia malayi Muscleblind-like protein 0.1293 0.3065 0.8764
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0037 0.0041
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0105 0.1144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.0766 0.2171
Treponema pallidum DNA ligase (lig) 0.0031 0.0032 0.0287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0092
Brugia malayi FAD binding domain containing protein 0.0033 0.0038 0.0109
Onchocerca volvulus 0.0074 0.0138 0.114
Schistosoma mansoni cpg binding protein 0.0062 0.0108 0.0121
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Onchocerca volvulus 0.0149 0.0318 0.2667
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Brugia malayi Myosin head containing protein 0.0019 0.0003 0.001
Brugia malayi TAR-binding protein 0.0066 0.0118 0.0336
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0032 0.0086
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0267
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0072 0.008
Brugia malayi hypothetical protein 0.0141 0.0297 0.0849
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.0356 0.1018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0037 0.0105
Schistosoma mansoni ran 0.0025 0.0018 0.002
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Echinococcus multilocularis tumor protein p63 0.0752 0.1767 0.1767
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0054 0.0088 0.0249
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0037 0.0041
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0037 0.0047 0.0043
Loa Loa (eye worm) flavodoxin family protein 0.002 0.0008 0.0023
Brugia malayi Polyprenyl synthetase family protein 0.1473 0.3498 1
Plasmodium falciparum lipid/sterol:H+ symporter 0.0019 0.0003 0.0004
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0372 0.0852 0.0953
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0047 0.0134
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0047 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0129 0.037
Brugia malayi hypothetical protein 0.0019 0.0003 0.001
Brugia malayi protein C24B5.3 0.0019 0.0003 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0037 0.0105
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.0356 0.0398
Brugia malayi hypothetical protein 0.0031 0.0032 0.0092
Brugia malayi hypothetical protein 0.0077 0.0143 0.041
Schistosoma mansoni cytochrome P450 reductase 0.0054 0.0088 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Entamoeba histolytica hypothetical protein 0.0031 0.0032 0.0287
Echinococcus multilocularis Niemann Pick C1 protein 0.0437 0.1008 0.1008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0138 0.0296
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0037 0.0047 0.0043
Plasmodium falciparum acyl-CoA synthetase 0.0094 0.0184 0.052
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.0565 0.1616
Entamoeba histolytica hypothetical protein 0.0077 0.0143 0.1602
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0037 0.0041
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0129 0.0145
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.1101 0.308
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0372 0.0852 1
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0066 0.0137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0037 0.0041
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0047 0.0134
Loa Loa (eye worm) hypothetical protein 0.1293 0.3065 0.8764
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0274 0.0762
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0002 0.0002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.0353 0.3914
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0138 0.0371
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0037 0.0041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0138 0.0296
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0002 0.0002
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0037 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0087 0.0097
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0006
Toxoplasma gondii flavodoxin domain-containing protein 0.0027 0.0023 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0118 0.0132
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0002 0.0002
Brugia malayi nuclear hormone receptor 0.0032 0.0037 0.0105
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0138 0.0296
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0033 0.0038 0.0043
Schistosoma mansoni importin beta-1 0.0067 0.012 0.0134
Entamoeba histolytica hypothetical protein 0.0077 0.0143 0.1602
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0037 0.0037
Toxoplasma gondii patched family protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0032 0.0069
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0372 0.0852 0.2359
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0037 0.0041
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0372 0.0852 1
Onchocerca volvulus 0.0032 0.0037 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0037 0.0105
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Schistosoma mansoni hypothetical protein 0.0149 0.0318 0.0355
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0105
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Plasmodium vivax importin-beta 2, putative 0.0067 0.012 0.0337
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.0184 0.0438
Brugia malayi Patched family protein 0.0019 0.0003 0.001
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0047 0.0073 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0037 0.0105
Echinococcus granulosus muscleblind protein 0.1293 0.3065 0.3429
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0037 0.0037
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1473 0.3498 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0002 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.026 0.0657

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.06 ug kg-1 Feeding inhibitory potency in 21 hr fasted rat was determined after 0.5 hr intravenous administration of the compound ChEMBL. 9435899
ED50 (functional) = 0.21 ug kg-1 Feeding inhibitory potency in 21 hr fasted rat was determined after 3h intravenous administration of the compound ChEMBL. 9435899
ED50 (functional) = 20 ug kg-1 Compound was tested to inhibit food intake after intranasal administration in dog ChEMBL. 9435899
Ki (binding) = 0.03 nM Binding affinity for Cholecystokinin type A receptor using [125I]-BH-CCK-8 in rat pancreatic tissue ChEMBL. 9435899
Ki (binding) = 0.03 nM Binding affinity for Cholecystokinin type A receptor using [125I]-BH-CCK-8 in rat pancreatic tissue ChEMBL. 9435899
Ki (binding) = 1600 nM Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes ChEMBL. 9435899
Ki (binding) = 1600 nM Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes ChEMBL. 9435899
Selectivity (binding) = 48000 Ratio of binding affinity towards CCK-A receptor to that of CCK-B receptor ChEMBL. 9435899
Selectivity (binding) = 48000 Ratio of binding affinity towards CCK-A receptor to that of CCK-B receptor ChEMBL. 9435899

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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