Detailed information for compound 271147

Basic information

Technical information
  • TDR Targets ID: 271147
  • Name: 6-(3-imidazol-1-ylpropyl)-3,4-dihydro-1H-quin olin-2-one
  • MW: 255.315 | Formula: C15H17N3O
  • H donors: 1 H acceptors: 2 LogP: 1.4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)ccc(c2)CCCn1cncc1
  • InChi: 1S/C15H17N3O/c19-15-6-4-13-10-12(3-5-14(13)17-15)2-1-8-18-9-7-16-11-18/h3,5,7,9-11H,1-2,4,6,8H2,(H,17,19)
  • InChiKey: XGUXGXUZMSOISN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[3-(1-imidazolyl)propyl]-3,4-dihydro-1H-quinolin-2-one
  • 6-(3-imidazol-1-ylpropyl)-3,4-dihydrocarbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major histone deacetylase, putative 0.0704 0.3235 0.5369
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0328 0.0533
Leishmania major trypanothione reductase 0.0038 0.0045 0.0021
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0046 0.0116
Schistosoma mansoni hypothetical protein 0.0145 0.0557 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0046 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0132 0.0315
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Leishmania major cathepsin L-like protease 0.0334 0.1461 0.2394
Plasmodium vivax vivapain-2 0.028 0.1203 0.3702
Plasmodium vivax plasmepsin V, putative 0.019 0.0774 0.2372
Onchocerca volvulus Histone deacetylase 10 homolog 0.0289 0.1247 0.206
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0134 0.0504 0.0827
Leishmania major cysteine peptidase A (CPA) 0.028 0.1203 0.1963
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0557 0.253 0.4682
Trypanosoma cruzi kinesin, putative 0.0045 0.0075 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.028 0.1203 0.3713
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0132 0.0315
Loa Loa (eye worm) fibroinase 0.028 0.1203 0.1994
Giardia lamblia Hypothetical protein 0.0057 0.0132 0.0337
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0177 0.071 0.1184
Loa Loa (eye worm) hypothetical protein 0.0557 0.253 0.421
Plasmodium falciparum peptidase, putative 0.0134 0.0504 0.1535
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0281 0.0262
Loa Loa (eye worm) peptidase family M13 containing protein 0.0411 0.1834 0.3047
Brugia malayi Cathepsin L-like precursor 0.028 0.1203 0.1994
Entamoeba histolytica cysteine protease, putative 0.028 0.1203 0.46
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0134 0.0504 0.0827
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.0172 0.0272
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0033 0.0054
Giardia lamblia Cathepsin L precursor 0.0065 0.0172 0.0496
Trypanosoma brucei prolyl oligopeptidase, putative 0.0509 0.2301 0.3827
Brugia malayi CXXC zinc finger family protein 0.0059 0.0143 0.0223
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Trypanosoma cruzi kinesin, putative 0.0045 0.0075 0.0071
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0136 0.0511 0.0511
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0032 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0249 0.04
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0134 0.0504 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Echinococcus granulosus histone deacetylase 6 0.0704 0.3235 0.5395
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0065 0.0172 0.0172
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1279 0.5997 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Trichomonas vaginalis set domain proteins, putative 0.0472 0.2124 0.6633
Onchocerca volvulus 0.0061 0.0151 0.0228
Loa Loa (eye worm) hypothetical protein 0.0421 0.188 0.3124
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0591 0.2695 0.2695
Loa Loa (eye worm) hypothetical protein 0.0176 0.0703 0.1158
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0272
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.0236
Toxoplasma gondii hypothetical protein 0.0049 0.0098 0.0149
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0221 0.0597
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0057 0.0132 0.0132
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0509 0.2301 0.3803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Echinococcus granulosus cathepsin l1 0.0193 0.0785 0.1309
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0065 0.0172 0.0505
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.1445 0.2399
Schistosoma mansoni neprilysin-2 (M13 family) 0.0281 0.1208 0.1208
Entamoeba histolytica cysteine protease, putative 0.0065 0.0172 0.0551
Trypanosoma cruzi cysteine peptidase, putative 0.0334 0.1461 0.2394
Loa Loa (eye worm) hypothetical protein 0.0321 0.1399 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.0785 0.2387
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0221 0.0656
Brugia malayi Cathepsin L-like precursor 0.0193 0.0785 0.1296
Trypanosoma cruzi cysteine peptidase, putative 0.028 0.1203 0.1963
Mycobacterium ulcerans beta-lactamase 0.0075 0.0221 0.0818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0046 0.0044
Entamoeba histolytica cysteine proteinase, putative 0.0193 0.0785 0.2959
Loa Loa (eye worm) hypothetical protein 0.0276 0.1183 0.1961
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0172 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0172 0.0443
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0046 0.0077
Mycobacterium tuberculosis Conserved protein 0.0075 0.0221 0.0331
Toxoplasma gondii prolyl endopeptidase 0.1279 0.5997 1
Schistosoma mansoni hypothetical protein 0.0099 0.0337 0.0337
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0167 0.0226
Schistosoma mansoni inositol monophosphatase 0.0159 0.0623 0.0623
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0035 0.0058
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0057 0.0132 0.0205
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0065 0.0172 0.0496
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.015 0.0581 0.0955
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0177 0.071 0.1184
Toxoplasma gondii aspartyl protease ASP1 0.0693 0.3186 0.5306
Brugia malayi Inositol-1 0.0159 0.0623 0.1025
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0065 0.0172 0.0505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Leishmania major hypothetical protein, conserved 0.006 0.015 0.0198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0221 0.0221
Plasmodium vivax aspartyl protease, putative 0.019 0.0774 0.2372
Plasmodium falciparum cysteine proteinase falcipain 3 0.028 0.1203 0.3702
Onchocerca volvulus 0.028 0.1203 0.1987
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.0504 0.0827
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0591 0.2695 0.4464
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1279 0.5997 0.5997
Brugia malayi Cathepsin L-like precursor 0.028 0.1203 0.1994
Toxoplasma gondii aspartyl protease 0.019 0.0774 0.1278
Loa Loa (eye worm) histone deacetylase 1 0.0567 0.2579 0.4291
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0635 0.1045
Brugia malayi cathepsin L-like cysteine proteinase 0.0065 0.0172 0.0272
Giardia lamblia Cathepsin B precursor 0.0228 0.0952 0.3577
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.0353
Mycobacterium tuberculosis Conserved protein 0.0075 0.0221 0.0331
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0221 0.0331
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0279 0.045
Trypanosoma brucei cysteine peptidase C (CPC) 0.0228 0.0952 0.1575
Entamoeba histolytica cysteine proteinase 1, putative 0.0152 0.059 0.2193
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0203 0.0339
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.185 0.3075
Toxoplasma gondii histone deacetylase HDAC1 0.0704 0.3235 0.5388
Schistosoma mansoni cathepsin S (C01 family) 0.0065 0.0172 0.0172
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0152 0.059 0.059
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0281 0.0445
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0151 0.0252
Schistosoma mansoni hypothetical protein 0.006 0.015 0.015
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0509 0.2301 0.9007
Echinococcus multilocularis inositol monophosphatase 1 0.0159 0.0623 0.1039
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0279 0.0413
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0136 0.0511 0.0511
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0046 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Entamoeba histolytica prolyl oligopeptidase family protein 0.0134 0.0504 0.1855
Echinococcus multilocularis cathepsin b 0.0591 0.2695 0.4494
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0281 0.0445
Schistosoma mansoni calpain-7 (C02 family) 0.0064 0.0167 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.028 0.1203 0.2007
Toxoplasma gondii histone deacetylase HDAC5 0.0289 0.1247 0.2067
Onchocerca volvulus 0.0089 0.0287 0.0455
Onchocerca volvulus 0.019 0.0774 0.1269
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.028 0.1203 0.2007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0151 0.0237
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0065 0.0172 0.0551
Brugia malayi BRCA1-associated protein 2 containing protein 0.0057 0.0132 0.0205
Trypanosoma brucei histone deacetylase 4 0.0704 0.3235 0.5388
Onchocerca volvulus 0.028 0.1203 0.1987
Leishmania major eukaryotic initiation factor 4a, putative 0.0321 0.1399 0.2292
Giardia lamblia Cathepsin B precursor 0.0065 0.0172 0.0496
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0172 0.0272
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.0353
Echinococcus granulosus histone deacetylase 6 0.0704 0.3235 0.5395
Echinococcus multilocularis histone deacetylase 3 0.0567 0.2579 0.43
Trichomonas vaginalis histone deacetylase, putative 0.0567 0.2579 0.8074
Echinococcus multilocularis cathepsin b 0.0591 0.2695 0.4494
Loa Loa (eye worm) hypothetical protein 0.0557 0.253 0.421
Giardia lamblia Histone deacetylase 0.0567 0.2579 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0046 0.0023
Loa Loa (eye worm) ctsf protein 0.028 0.1203 0.1994
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0249 0.0742
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Trypanosoma cruzi histone deacetylase, putative 0.0289 0.1247 0.2036
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0281 0.1208 0.1208
Plasmodium falciparum serine repeat antigen 2 0.0065 0.0172 0.0505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.059 0.097
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0172 0.0443
Echinococcus multilocularis histone deacetylase 8 0.0289 0.1247 0.2079
Giardia lamblia Cysteine protease 0.0065 0.0172 0.0496
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0015 0.0015
Mycobacterium tuberculosis Probable peptidase 0.0509 0.2301 0.425
Onchocerca volvulus 0.0472 0.2124 0.3527
Toxoplasma gondii cathepsin CPL 0.028 0.1203 0.1994
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0032 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.019 0.0774 0.1278
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0065 0.0172 0.0496
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0557 0.253 0.253
Echinococcus granulosus cathepsin L cysteine protease 0.0152 0.059 0.0984
Entamoeba histolytica hypothetical protein, conserved 0.0134 0.0504 0.1855
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0015 0.0015
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0046 0.0058
Leishmania major hypothetical protein, conserved 0.0057 0.0132 0.0166
Mycobacterium ulcerans hypothetical protein 0.0075 0.0221 0.0818
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0136 0.0511 0.0511
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.3714 0.6194
Echinococcus granulosus histone deacetylase 7 0.0704 0.3235 0.5395
Entamoeba histolytica prolyl oligopeptidase family protein 0.0134 0.0504 0.1855
Brugia malayi cathepsin L-like precursor 0.0193 0.0785 0.1296
Echinococcus multilocularis prolyl endopeptidase 0.1279 0.5997 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0221 0.0331
Onchocerca volvulus Cathepsin F homolog 0.028 0.1203 0.1987
Brugia malayi glutathione reductase 0.0038 0.0045 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0221 0.0597
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0057 0.0095
Loa Loa (eye worm) histone deacetylase 11 0.0289 0.1247 0.2067
Schistosoma mansoni cathepsin D (A01 family) 0.2114 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Leishmania major kinesin, putative 0.0045 0.0075 0.0071
Entamoeba histolytica cysteine proteinase 2 0.0152 0.059 0.2193
Brugia malayi cathepsin F-like cysteine proteinase 0.0065 0.0172 0.0272
Giardia lamblia Cathepsin L precursor 0.0065 0.0172 0.0496
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0057 0.0132 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0172 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0281 0.0445
Onchocerca volvulus 0.028 0.1203 0.1987
Schistosoma mansoni lipoxygenase 0.0055 0.0123 0.0123
Brugia malayi Pre-SET motif family protein 0.0415 0.185 0.3075
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0272
Toxoplasma gondii hypothetical protein 0.0134 0.0504 0.0827
Trichomonas vaginalis inositol monophosphatase, putative 0.0159 0.0623 0.1872
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0065 0.0172 0.0496
Plasmodium falciparum plasmepsin X 0.0436 0.1951 0.6021
Loa Loa (eye worm) cysteine protease 0.028 0.1203 0.1994
Onchocerca volvulus 0.0193 0.0785 0.1288
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0057 0.0132 0.0393
Echinococcus multilocularis histone deacetylase 0.0704 0.3235 0.5395
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0172 0.0443
Plasmodium falciparum serine repeat antigen 3 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.0421 0.188 0.3124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0245 0.0245
Onchocerca volvulus Cathepsin L homolog 0.0065 0.0172 0.0263
Loa Loa (eye worm) hypothetical protein 0.0487 0.2196 0.3652
Loa Loa (eye worm) hypothetical protein 0.0134 0.0504 0.0827
Brugia malayi Trypsin-like protease protein 5 0.0032 0.0015 0.0009
Loa Loa (eye worm) beta-lactamase 0.0075 0.0221 0.0353
Echinococcus granulosus cathepsin L 0.0065 0.0172 0.0287
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0057 0.0132 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.0504 0.0791
Loa Loa (eye worm) hypothetical protein 0.0193 0.0785 0.1296
Plasmodium falciparum histone deacetylase, putative 0.0704 0.3235 1
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0045 0.0111
Trichomonas vaginalis BRCA1-associated protein, putative 0.0057 0.0132 0.0315
Plasmodium vivax glutathione reductase, putative 0.0038 0.0045 0.0111
Echinococcus granulosus histone deacetylase 8 0.0289 0.1247 0.2079
Echinococcus granulosus tissue type plasminogen activator 0.006 0.015 0.0251
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0033 0.0003
Echinococcus multilocularis BRCA1 associated protein 0.0057 0.0132 0.022
Brugia malayi Trypsin family protein 0.0032 0.0015 0.0009
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0321 0.1399 0.1399
Plasmodium falciparum cysteine proteinase falcipain 2b 0.028 0.1203 0.3702
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0172 0.0443
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0134 0.0504 0.1496
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0159 0.0623 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0177 0.071 0.071
Onchocerca volvulus 0.0121 0.0441 0.0712
Brugia malayi hypothetical protein 0.0052 0.0111 0.017
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0321 0.1399 0.2551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0132 0.0315
Onchocerca volvulus 0.0099 0.0337 0.0539
Brugia malayi PHD-finger family protein 0.0032 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0411 0.1834 0.3047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0228 0.0952 0.2917
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0281 0.1208 0.1208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.216 0.3985
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0145 0.0557 0.0557
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0172 0.0172
Entamoeba histolytica cysteine protease, putative 0.0065 0.0172 0.0551
Toxoplasma gondii aspartyl protease ASP3 0.0436 0.1951 0.3244
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0057 0.0132 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0247 0.1047 0.1745
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0142 0.0543 0.1396
Entamoeba histolytica cysteine protease, putative 0.0065 0.0172 0.0551
Schistosoma mansoni hypothetical protein 0.0145 0.0557 0.0557
Brugia malayi histone deacetylase 11 0.0289 0.1247 0.2067
Schistosoma mansoni hypothetical protein 0.0036 0.0035 0.0035
Plasmodium falciparum plasmepsin V 0.019 0.0774 0.2372
Onchocerca volvulus 0.0059 0.0143 0.0214
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0064 0.0167 0.0226
Trypanosoma brucei histone deacetylase 3 0.0704 0.3235 0.5388
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0228 0.0952 0.1542
Schistosoma mansoni brca1-associated protein (brap2) 0.0057 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0081 0.0249 0.04
Leishmania major histone deacetylase, putative 0.0704 0.3235 0.5369
Plasmodium falciparum serine repeat antigen 8 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.0353
Toxoplasma gondii peptidase family M13 protein 0.0557 0.253 0.421
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0152 0.059 0.0935
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0046 0.0126
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1279 0.5997 0.5997
Entamoeba histolytica histone deacetylase, putative 0.0567 0.2579 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0509 0.2301 0.3803
Brugia malayi Cathepsin L-like precursor 0.028 0.1203 0.1994
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0143 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0172 0.0443
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0249 0.0742
Loa Loa (eye worm) hypothetical protein 0.0591 0.2695 0.4486
Echinococcus granulosus cathepsin L 0.0152 0.059 0.0984
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0033 0.0039
Brugia malayi RNA, U transporter 1 0.0088 0.0283 0.0457
Onchocerca volvulus 0.019 0.0774 0.1269
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0221 0.0353
Loa Loa (eye worm) aspartyl protease 6 0.019 0.0774 0.1278
Schistosoma mansoni cathepsin F (C01 family) 0.0193 0.0785 0.0785
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0057 0.0132 0.0205
Loa Loa (eye worm) hypothetical protein 0.0421 0.188 0.3124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0418 0.0683
Echinococcus multilocularis calpain A 0.0177 0.071 0.1184
Loa Loa (eye worm) calpain family protein 1 0.0169 0.0673 0.1109
Entamoeba histolytica cysteine protease, putative 0.0065 0.0172 0.0551
Entamoeba histolytica cysteine protease, putative 0.0065 0.0172 0.0551
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0172 0.0172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0048 0.0079
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.0353
Trypanosoma cruzi histone deacetylase, putative 0.0704 0.3235 0.5369
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Echinococcus multilocularis calpain 7 (C02 family) 0.0064 0.0167 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.0504 0.0791
Entamoeba histolytica prolyl oligopeptidase family protein 0.0134 0.0504 0.1855
Onchocerca volvulus 0.0075 0.0221 0.0344
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0123 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.0785 0.2387
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0279 0.045
Loa Loa (eye worm) hypothetical protein 0.0044 0.007 0.0102
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Brugia malayi cathepsin L precursor 0.0065 0.0172 0.0272
Plasmodium vivax SET domain protein, putative 0.0061 0.0151 0.0441
Schistosoma mansoni hypothetical protein 0.0353 0.1555 0.1555
Loa Loa (eye worm) hypothetical protein 0.0193 0.0785 0.1296
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0221 0.0597
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Trypanosoma cruzi major cysteine proteinase, putative 0.0119 0.0429 0.0665
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0046 0.0023
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0136 0.0511 0.0511
Plasmodium falciparum glutathione reductase 0.0038 0.0045 0.0111
Echinococcus granulosus cathepsin L cysteine proteinase 0.028 0.1203 0.2007
Leishmania major cathepsin L-like protease 0.028 0.1203 0.1963
Echinococcus granulosus calpain 0.0064 0.0167 0.0279
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0693 0.3186 0.5313
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0065 0.0172 0.0272
Leishmania major cathepsin L-like protease 0.028 0.1203 0.1963
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0159 0.0623 0.099
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0087 0.0279 0.045
Loa Loa (eye worm) calpain 0.0064 0.0167 0.0264
Toxoplasma gondii cathepsin CPC2 0.0065 0.0172 0.0272
Trypanosoma brucei antigen, putative 0.0064 0.0167 0.0264
Brugia malayi Peptidase family M13 containing protein 0.0557 0.253 0.421
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0009
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0057 0.0132 0.0205
Brugia malayi cathepsin Z-like cysteine proteinase 0.0065 0.0172 0.0272
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0057 0.0132 0.022
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0032 0.0015 0.0009
Giardia lamblia Cathepsin B precursor 0.0065 0.0172 0.0496
Loa Loa (eye worm) hypothetical protein 0.0052 0.011 0.0168
Loa Loa (eye worm) aspartic protease BmAsp-1 0.019 0.0774 0.1278
Echinococcus multilocularis cathepsin L cysteine protease 0.028 0.1203 0.2007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0557 0.088
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0032 0.0015 0.0025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0159 0.0623 0.1025
Echinococcus granulosus calpain 5 0.0064 0.0167 0.0279
Echinococcus granulosus eukaryotic initiation factor 4A 0.0321 0.1399 0.2334
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0065 0.0172 0.0505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0172 0.0443
Entamoeba histolytica cysteine proteinase, putative 0.028 0.1203 0.46
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0247 0.1047 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0065 0.0172 0.0443
Giardia lamblia Cathepsin L-like protease 0.0065 0.0172 0.0496
Echinococcus granulosus cathepsin l1 0.028 0.1203 0.2007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0249 0.04
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0015 0.0015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0245 0.0408
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0159 0.0623 0.2418
Brugia malayi Cathepsin L-like precursor 0.0193 0.0785 0.1296
Echinococcus multilocularis calpain 0.0064 0.0167 0.0279
Onchocerca volvulus 0.0075 0.0221 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0134 0.0504 0.0841
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0134 0.0504 0.0791
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0057 0.0132 0.0205
Giardia lamblia Cathepsin B precursor 0.0065 0.0172 0.0496
Onchocerca volvulus 0.0075 0.0221 0.0344
Brugia malayi Pepsin A precursor 0.019 0.0774 0.1278
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0247 0.1047 0.1745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0221 0.0368
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Schistosoma mansoni Mername-AA248 (C02 family) 0.0064 0.0167 0.0167
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.0504 0.0827
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0057 0.0132 0.0205
Brugia malayi peptidase family M13 containing protein 0.0136 0.0511 0.0838
Trypanosoma cruzi cysteine protease, putative 0.0152 0.059 0.0935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.1047 0.1047
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0279 0.0413
Brugia malayi histone deacetylase 1 (HD1) 0.0567 0.2579 0.4291
Brugia malayi hypothetical protein 0.019 0.0774 0.1278
Giardia lamblia Encystation-specific protease 0.0065 0.0172 0.0496
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0167 0.0226
Schistosoma mansoni hypothetical protein 0.0145 0.0557 0.0557
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0015 0.0015
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0321 0.1399 0.4334
Brugia malayi Pre-SET motif family protein 0.0061 0.0151 0.0237
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0221 0.0368
Plasmodium falciparum serine repeat antigen 6 0.0065 0.0172 0.0505
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0321 0.1399 0.537
Schistosoma mansoni cathepsin s 0.0087 0.0279 0.0279
Brugia malayi beta-lactamase family protein 0.0075 0.0221 0.0353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Trypanosoma brucei glucosidase, putative 0.0036 0.0033 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.1047 0.1047
Loa Loa (eye worm) histone deacetylase 7A 0.0704 0.3235 0.5388
Brugia malayi Bromodomain containing protein 0.0089 0.0287 0.0463
Trichomonas vaginalis esterase, putative 0.0075 0.0221 0.0597
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0272
Mycobacterium tuberculosis Probable reductase 0.0088 0.0281 0.0445
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0057 0.0132 0.0205
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0123 0.0205
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Plasmodium falciparum serine repeat antigen 4 0.0065 0.0172 0.0505
Entamoeba histolytica hypothetical protein 0.0065 0.0172 0.0551
Leishmania major cathepsin L-like protease 0.0334 0.1461 0.2394
Giardia lamblia Hypothetical protein 0.0065 0.0172 0.0496
Plasmodium falciparum cysteine proteinase falcipain 2a 0.028 0.1203 0.3702
Toxoplasma gondii cathepsin CPC1 0.0065 0.0172 0.0272
Giardia lamblia Cathepsin L precursor 0.0065 0.0172 0.0496
Onchocerca volvulus 0.0105 0.0367 0.0588
Schistosoma mansoni endothelin-converting enzyme-related 0.0136 0.0511 0.0511
Giardia lamblia Cathepsin B precursor 0.0228 0.0952 0.3577
Echinococcus granulosus calpain A 0.0064 0.0167 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0245 0.0245
Onchocerca volvulus 0.028 0.1203 0.1987
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0045 0.0021
Onchocerca volvulus 0.0093 0.0309 0.0491
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0221 0.0331
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0281 0.1208 0.1208
Schistosoma mansoni bromodomain containing protein 0.0075 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0421 0.188 0.3124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0321 0.1399 0.2334
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Brugia malayi beta-lactamase family protein 0.0075 0.0221 0.0353
Plasmodium vivax vivapain-3 0.0152 0.059 0.1801
Echinococcus granulosus calpain 7 C02 family 0.0064 0.0167 0.0279
Echinococcus multilocularis cathepsin L 0.0065 0.0172 0.0287
Plasmodium vivax cysteine repeat modular protein 1, putative 0.006 0.015 0.0438
Loa Loa (eye worm) hypothetical protein 0.0046 0.0083 0.0124
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0635 0.1059
Mycobacterium ulcerans zinc metalloprotease 0.0557 0.253 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0032 0.0015 0.0025
Plasmodium falciparum cysteine repeat modular protein 1 0.006 0.015 0.0438
Brugia malayi Protein kinase domain containing protein 0.006 0.015 0.0236
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0065 0.0172 0.0505
Brugia malayi Histone deacetylase family protein 0.0704 0.3235 0.5388
Plasmodium falciparum plasmepsin I 0.0693 0.3186 0.9848
Echinococcus granulosus histone deacetylase 1 0.0567 0.2579 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Brugia malayi hypothetical protein 0.0081 0.0249 0.04
Giardia lamblia Cathepsin L-like protease 0.0065 0.0172 0.0496
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0057 0.0132 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.015 0.0198
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0167 0.0264
Trichomonas vaginalis brca1-associated protein, putative 0.0057 0.0132 0.0315
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0057 0.0132 0.0166
Onchocerca volvulus Prolyl endopeptidase homolog 0.1279 0.5997 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0509 0.2301 0.3827
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0272
Loa Loa (eye worm) hypothetical protein 0.0411 0.1834 0.3047
Echinococcus multilocularis hypothetical protein 0.0064 0.0167 0.0279
Plasmodium vivax RNA helicase-1, putative 0.0321 0.1399 0.431
Giardia lamblia Alanyl dipeptidyl peptidase 0.0134 0.0504 0.1808
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0264
Plasmodium falciparum histone deacetylase 1 0.0567 0.2579 0.7966
Brugia malayi Cathepsin L-like precursor 0.028 0.1203 0.1994
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0228 0.0952 0.1542
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0134 0.0504 0.0791
Loa Loa (eye worm) hypothetical protein 0.0105 0.0367 0.0597
Plasmodium vivax aspartyl proteinase, putative 0.0693 0.3186 0.9848
Giardia lamblia Alanyl dipeptidyl peptidase 0.0134 0.0504 0.1808
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0167 0.0226
Plasmodium falciparum plasmepsin VII 0.019 0.0774 0.2372
Echinococcus multilocularis enteropeptidase 0.0032 0.0015 0.0025
Trypanosoma cruzi cruzipain precursor, putative 0.0334 0.1461 0.2394
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0065 0.0172 0.0505
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0221 0.0818
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0221 0.0597
Leishmania major cathepsin L-like protease 0.028 0.1203 0.1963
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.059 0.097
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0068 0.0098
Echinococcus multilocularis acylamino acid releasing enzyme 0.0134 0.0504 0.0841
Echinococcus granulosus Dipeptidyl peptidase 9 0.0134 0.0504 0.0841
Giardia lamblia Cathepsin B precursor 0.0065 0.0172 0.0496
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0557 0.253 0.421
Plasmodium falciparum serine repeat antigen 5 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.0567 0.2579 0.4291
Toxoplasma gondii histone deacetylase HDAC4 0.0289 0.1247 0.2067
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0172 0.0272
Toxoplasma gondii histone deacetylase HDAC3 0.0567 0.2579 0.4291
Trypanosoma cruzi prolyl endopeptidase 0.1279 0.5997 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0151 0.0151
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.0504 0.0504
Toxoplasma gondii preprocathepsin c precursor, putative 0.0065 0.0172 0.0272
Plasmodium falciparum plasmepsin II 0.0693 0.3186 0.9848
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0221 0.0331
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Trypanosoma cruzi histone deacetylase 1, putative 0.0567 0.2579 0.4269
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0057 0.0132 0.038
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.059 0.097
Entamoeba histolytica cysteine protease, putative 0.0065 0.0172 0.0551
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0635 0.1045
Giardia lamblia Cathepsin L precursor 0.0065 0.0172 0.0496
Loa Loa (eye worm) hypothetical protein 0.0471 0.212 0.3525
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0134 0.0504 0.1855
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0065 0.0172 0.0551
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0057 0.0132 0.0205
Onchocerca volvulus Cathepsin L homolog 0.028 0.1203 0.1987
Schistosoma mansoni calpain-7 (C02 family) 0.0064 0.0167 0.0167
Brugia malayi fibroinase precursor 0.0065 0.0172 0.0272
Leishmania major cathepsin L-like protease 0.028 0.1203 0.1963
Echinococcus granulosus cathepsin b 0.0591 0.2695 0.4494
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0281 0.1208 0.1208
Giardia lamblia Cathepsin B precursor 0.0228 0.0952 0.3577
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0065 0.0172 0.0272
Brugia malayi calpain 5 0.0045 0.0075 0.011
Schistosoma mansoni histone deacetylase hda2 0.0289 0.1247 0.1247
Echinococcus multilocularis histone deacetylase 6 0.076 0.3506 0.5847
Schistosoma mansoni cpg binding protein 0.0064 0.0169 0.0169
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0134 0.0504 0.1855
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0176 0.0703 0.1158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0591 0.2695 0.2695
Echinococcus granulosus survival motor neuron protein 1 0.0487 0.2196 0.3662
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0167 0.0226
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.0504 0.0827
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0057 0.0132 0.0205
Schistosoma mansoni hypothetical protein 0.0353 0.1555 0.1555
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0046 0.0044
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0057 0.0132 0.038
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0134 0.0504 0.0841
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1333 0.218
Echinococcus multilocularis endothelin converting enzyme 1 0.0557 0.253 0.4219
Leishmania major histone deacetylase, putative 0.0567 0.2579 0.4269
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0591 0.2695 0.2695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Loa Loa (eye worm) papain family cysteine protease containing protein 0.028 0.1203 0.1994
Echinococcus granulosus histone deacetylase 3 0.0567 0.2579 0.43
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.059 0.2193
Plasmodium vivax plasmepsin IV, putative 0.0693 0.3186 0.9848
Echinococcus granulosus cysteine protease 0.0152 0.059 0.0984
Loa Loa (eye worm) hypothetical protein 0.1279 0.5997 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0134 0.0504 0.0791
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0159 0.0623 0.099
Schistosoma mansoni histone deacetylase 4 5 0.0704 0.3235 0.3235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Echinococcus granulosus transmembrane protease serine 3 0.0032 0.0015 0.0025
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0134 0.0504 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0221 0.0315
Leishmania major cathepsin L-like protease 0.0334 0.1461 0.2394
Leishmania major hypothetical protein, conserved 0.0075 0.0221 0.0315
Brugia malayi Trypsin family protein 0.0032 0.0015 0.0009
Plasmodium vivax unspecified product 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.0125 0.0459 0.0751
Brugia malayi cathepsin B-like cysteine proteinase 0.0591 0.2695 0.4486
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0033 0.0039
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Loa Loa (eye worm) peptidase family M13 containing protein 0.0411 0.1834 0.3047
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0221 0.0331
Plasmodium vivax vivapain-2 0.028 0.1203 0.3702
Plasmodium vivax histone deacetylase, putative 0.0704 0.3235 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0134 0.0504 0.0827
Brugia malayi Cathepsin L-like precursor 0.028 0.1203 0.1994
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0065 0.0172 0.0505
Echinococcus granulosus prolyl endopeptidase 0.1279 0.5997 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0337 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0504 0.1496
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0441 0.0441
Echinococcus granulosus calpain A 0.0177 0.071 0.1184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0057 0.0132 0.0205
Loa Loa (eye worm) hypothetical protein 0.0087 0.0279 0.045
Plasmodium falciparum plasmepsin IV 0.0693 0.3186 0.9848
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0057 0.0132 0.0196
Echinococcus multilocularis cathepsin L cysteine protease 0.028 0.1203 0.2007
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0057 0.0132 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0247 0.1047 0.1745
Plasmodium vivax aspartyl protease, putative 0.0436 0.1951 0.6021
Trichomonas vaginalis histone deacetylase, putative 0.0567 0.2579 0.8074
Plasmodium vivax serine-repeat antigen (SERA) 0.0065 0.0172 0.0505
Trypanosoma cruzi cysteine peptidase, putative 0.0334 0.1461 0.2394
Schistosoma mansoni importin beta-1 0.0031 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0279 0.045
Plasmodium falciparum serine repeat antigen 7 0.0065 0.0172 0.0505
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0328 0.0533
Trichomonas vaginalis histone deacetylase, putative 0.0567 0.2579 0.8074
Trichomonas vaginalis histone deacetylase, putative 0.0567 0.2579 0.8074
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0167 0.0264
Schistosoma mansoni histone deacetylase hda2 0.076 0.3506 0.3506
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0033 0.0039
Brugia malayi hypothetical protein 0.0036 0.0032 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1333 0.218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Echinococcus multilocularis calpain 5 0.0064 0.0167 0.0279
Plasmodium falciparum eukaryotic initiation factor 4A 0.0321 0.1399 0.431
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.059 0.2193
Loa Loa (eye worm) hypothetical protein 0.0421 0.188 0.3124
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0065 0.0172 0.0443
Onchocerca volvulus 0.0065 0.0172 0.0263
Echinococcus multilocularis cysteine protease 0.028 0.1203 0.2007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0046 0.0077
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0045 0.006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0557 0.088
Loa Loa (eye worm) hypothetical protein 0.0557 0.253 0.421
Plasmodium vivax vivapain-1 0.0152 0.059 0.1801
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0152 0.059 0.059
Loa Loa (eye worm) cathepsin B 0.0228 0.0952 0.1575
Leishmania major hypothetical protein, conserved 0.0081 0.0249 0.0362
Loa Loa (eye worm) hypothetical protein 0.0693 0.3186 0.5306
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0032 0.0015 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0249 0.0362
Brugia malayi Cathepsin L-like precursor 0.0087 0.0279 0.045
Loa Loa (eye worm) hypothetical protein 0.0289 0.1247 0.2067
Brugia malayi Trypsin family protein 0.0032 0.0015 0.0009
Schistosoma mansoni histone deacetylase 0.0567 0.2579 0.2579
Plasmodium falciparum plasmepsin VIII, putative 0.019 0.0774 0.2372
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.0172 0.0234
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.059 0.2193
Schistosoma mansoni brca1-associated protein (brap2) 0.0057 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0081 0.0247 0.0398
Brugia malayi Cathepsin L-like precursor 0.028 0.1203 0.1994
Trypanosoma brucei oligopeptidase b 0.0509 0.2301 0.3827
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.019 0.0774 0.1278
Schistosoma mansoni cpg binding protein 0.0064 0.0169 0.0169
Trypanosoma brucei histone deacetylase 2 0.0289 0.1247 0.2067
Brugia malayi aspartic protease BmAsp-1, identical 0.019 0.0774 0.1278
Schistosoma mansoni histone deacetylase 0.0567 0.2579 0.2579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Leishmania major histone deacetylase, putative 0.0567 0.2579 0.4269
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0441 0.0441
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0033 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0272
Echinococcus multilocularis cysteine protease 0.028 0.1203 0.2007
Schistosoma mansoni hypothetical protein 0.0145 0.0557 0.0557
Echinococcus multilocularis snurportin 1 0.033 0.1445 0.241
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0057 0.0132 0.0166
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Echinococcus multilocularis histone deacetylase 6 0.0704 0.3235 0.5395
Onchocerca volvulus 0.0276 0.1183 0.1953
Echinococcus multilocularis Mastin 0.0032 0.0015 0.0025
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0321 0.1399 0.5343
Toxoplasma gondii histone deacetylase HDAC2 0.0567 0.2579 0.4291
Giardia lamblia Cathepsin L precursor 0.0065 0.0172 0.0496
Echinococcus granulosus Mastin 0.0032 0.0015 0.0025
Plasmodium falciparum histone deacetylase 2 0.0704 0.3235 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0328 0.0533
Brugia malayi beta-lactamase 0.0075 0.0221 0.0353
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0693 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0009
Giardia lamblia Cathepsin B precursor 0.0065 0.0172 0.0496
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0065 0.0172 0.0505
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Plasmodium vivax histone deacetylase, putative 0.0289 0.1247 0.3837
Leishmania major cathepsin L-like protease 0.028 0.1203 0.1963
Trichomonas vaginalis histone deacetylase, putative 0.0567 0.2579 0.8074
Giardia lamblia Cysteine protease 0.0065 0.0172 0.0496
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0035 0.0058
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0015 0.0025
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0032 0.0015 0.0025
Brugia malayi Cathepsin L-like cysteine proteinase 0.0193 0.0785 0.1296
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0134 0.0504 0.0504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.019 0.0774 0.1278
Loa Loa (eye worm) TK/ROR protein kinase 0.006 0.015 0.0236
Schistosoma mansoni hypothetical protein 0.0145 0.0557 0.0557
Mycobacterium ulcerans lipase LipD 0.0075 0.0221 0.0818
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0321 0.1399 0.4334
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0134 0.0504 0.0504
Entamoeba histolytica protein kinase, putative 0.0045 0.0075 0.017
Loa Loa (eye worm) calpain family protein 1 0.0125 0.0459 0.0751
Onchocerca volvulus 0.028 0.1203 0.1987
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0321 0.1399 0.2292
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0159 0.0623 0.1872
Schistosoma mansoni histone deacetylase 4 5 0.0704 0.3235 0.3235
Mycobacterium leprae probable zinc metalloprotease 0.0557 0.253 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0065 0.0172 0.0505
Schistosoma mansoni ap endonuclease 0.0039 0.0046 0.0046
Echinococcus granulosus cathepsin b 0.0591 0.2695 0.4494
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0557 0.0915
Loa Loa (eye worm) prolyl oligopeptidase 0.0134 0.0504 0.0827
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0245 0.0408
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0065 0.0172 0.0172
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0693 0.3186 0.5306
Loa Loa (eye worm) calpain 5 0.0045 0.0075 0.011
Echinococcus multilocularis transmembrane protease serine 3 0.0032 0.0015 0.0025
Echinococcus multilocularis tissue type plasminogen activator 0.006 0.015 0.0251
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0057 0.0132 0.022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0221 0.0353
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0221 0.0331
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0635 0.1059
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0057 0.0132 0.0205
Brugia malayi Kringle domain containing protein 0.006 0.015 0.0236
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0221 0.0818
Trypanosoma brucei histone deacetylase 1 0.0567 0.2579 0.4291
Loa Loa (eye worm) histone deacetylase 3 0.0567 0.2579 0.4291
Toxoplasma gondii ABC1 family protein 0.0075 0.0221 0.0353
Schistosoma mansoni alpha-glucosidase 0.0139 0.0527 0.0527
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0057 0.0132 0.038
Toxoplasma gondii kringle domain-containing protein 0.006 0.015 0.0236
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0057 0.0132 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0172 0.0443
Echinococcus granulosus snurportin 1 0.033 0.1445 0.241
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0057 0.0132 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.028 0.1203 0.3713
Loa Loa (eye worm) hypothetical protein 0.0169 0.0673 0.1109
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.0504 0.0827
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0167 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0334 0.1461 0.2394
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0065 0.0172 0.0172
Echinococcus multilocularis survival motor neuron protein 1 0.0487 0.2196 0.3662
Loa Loa (eye worm) hypothetical protein 0.0421 0.188 0.3124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0249 0.0742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.059 0.097
Schistosoma mansoni cpg binding protein 0.0059 0.0143 0.0143
Trypanosoma cruzi cysteine proteinase, putative 0.0152 0.059 0.0935
Plasmodium vivax hypothetical protein, conserved 0.0134 0.0504 0.1535
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0046 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0151 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0221 0.0315
Toxoplasma gondii thioredoxin reductase 0.0038 0.0045 0.006
Loa Loa (eye worm) hypothetical protein 0.0415 0.1849 0.3073
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0321 0.1399 0.2315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.059 0.1768
Schistosoma mansoni alpha-glucosidase 0.0139 0.0527 0.0527
Brugia malayi Bromodomain containing protein 0.0044 0.007 0.0102
Treponema pallidum ATP-dependent RNA helicase 0.0321 0.1399 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0046 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0247 0.1047 0.1733
Mycobacterium ulcerans hypothetical protein 0.0162 0.0636 0.247
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0068 0.0059
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0567 0.2579 0.8074
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Plasmodium falciparum plasmepsin VI 0.0693 0.3186 0.9848
Schistosoma mansoni survival motor neuron protein 0.0099 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0121 0.0441 0.0721
Leishmania major eukaryotic initiation factor 4a, putative 0.0321 0.1399 0.2292
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0134 0.0504 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0172 0.0443
Echinococcus granulosus enteropeptidase 0.0032 0.0015 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0172 0.0443
Brugia malayi hypothetical protein 0.0032 0.0015 0.0009
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0064 0.0167 0.0264
Trypanosoma cruzi oligopeptidase b 0.0509 0.2301 0.3803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0172 0.0172
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0065 0.0172 0.0496
Onchocerca volvulus 0.006 0.015 0.0227
Trichomonas vaginalis histone deacetylase, putative 0.0567 0.2579 0.8074
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0172 0.0443
Leishmania major oligopeptidase b 0.0509 0.2301 0.3803
Schistosoma mansoni alpha glucosidase 0.0036 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0009
Schistosoma mansoni memapsin-2 (A01 family) 0.019 0.0774 0.0774
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1145 0.5353 1
Schistosoma mansoni cathepsin B (C01 family) 0.0065 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.033 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0009
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0152 0.059 0.059
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0134 0.0504 0.0827
Brugia malayi calpain family protein 1 0.0169 0.0673 0.1109
Plasmodium vivax unspecified product 0.0087 0.0279 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0065 0.0172 0.0443
Loa Loa (eye worm) hypothetical protein 0.0411 0.1834 0.3047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.0774 0.0774
Onchocerca volvulus 0.028 0.1203 0.1987
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0057 0.0132 0.038
Echinococcus multilocularis cathepsin L 0.0152 0.059 0.0984
Brugia malayi Eukaryotic aspartyl protease family protein 0.019 0.0774 0.1278
Schistosoma mansoni inositol monophosphatase 0.0159 0.0623 0.0623
Onchocerca volvulus 0.028 0.1203 0.1987
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0635 0.1059
Loa Loa (eye worm) hypothetical protein 0.008 0.0245 0.0393
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0693 0.3186 0.5306
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0159 0.0623 0.2321
Plasmodium vivax aspartyl proteinase, putative 0.019 0.0774 0.2372
Trypanosoma brucei histone deacetylase, putative 0.0704 0.3235 0.5388
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0065 0.0172 0.0505
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0172 0.0172
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0281 0.0445
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0159 0.0623 0.099
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.1333 0.221
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0048 0.0079
Brugia malayi Histone deacetylase 1 0.0567 0.2579 0.4291
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0057 0.0132 0.0205
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0221 0.0597
Brugia malayi calpain family protein 1 0.0169 0.0673 0.1109
Plasmodium falciparum thioredoxin reductase 0.0038 0.0045 0.0111
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0272
Plasmodium vivax serine-repeat antigen (SERA) 0.0065 0.0172 0.0505
Loa Loa (eye worm) hypothetical protein 0.0411 0.1834 0.3047
Loa Loa (eye worm) glutathione reductase 0.0038 0.0045 0.006
Plasmodium vivax calpain, putative 0.0064 0.0167 0.049
Loa Loa (eye worm) trypsin family protein 0.0032 0.0015 0.0009
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0057 0.0132 0.0205
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0169 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.028 0.1203 0.1994
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0469 0.0469
Giardia lamblia Cysteine protease 0.0065 0.0172 0.0496
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0967 0.16
Echinococcus multilocularis calpain family protein 1, d 0.0125 0.0459 0.0765
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0567 0.2579 0.8074
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0159 0.0623 0.1025
Schistosoma mansoni calpain (C02 family) 0.0064 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0134 0.0504 0.0827
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0193 0.0785 0.1296
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0221 0.0331
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0172 0.0272
Brugia malayi prolyl oligopeptidase family protein 0.1279 0.5997 1
Giardia lamblia Cysteine protease 0.0065 0.0172 0.0496
Brugia malayi aspartic protease BmAsp-2, identical 0.019 0.0774 0.1278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0136 0.0511 0.0511
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0321 0.1399 0.2322
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0057 0.0132 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.028 0.1203 0.3713
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0281 0.0445
Toxoplasma gondii cathepsin B 0.0228 0.0952 0.1575
Loa Loa (eye worm) histone deacetylase 0.0704 0.3235 0.5388
Plasmodium falciparum plasmepsin IX 0.0436 0.1951 0.6021
Plasmodium falciparum serine repeat antigen 1 0.0065 0.0172 0.0505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.059 0.1768
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0172 0.0443
Trypanosoma cruzi histone deacetylase 1, putative 0.0567 0.2579 0.4269
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0321 0.1399 0.2334
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.068 0.2052
Schistosoma mansoni cathepsin F (C01 family) 0.028 0.1203 0.1203
Brugia malayi calpain 7 0.0064 0.0167 0.0264
Echinococcus granulosus endothelin converting enzyme 1 0.0557 0.253 0.4219
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0134 0.0504 0.1496
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0057 0.0132 0.022
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.0353
Trypanosoma brucei trypanothione reductase 0.0038 0.0045 0.006
Trypanosoma brucei kinesin, putative 0.0045 0.0075 0.011
Loa Loa (eye worm) hypothetical protein 0.0121 0.0441 0.0721
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0068 0.0059
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0321 0.1399 0.2292
Schistosoma mansoni hypothetical protein 0.0036 0.0032 0.0032
Echinococcus granulosus inositol monophosphatase 1 0.0159 0.0623 0.1039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0113 0.0135
Plasmodium falciparum serine repeat antigen 9 0.0065 0.0172 0.0505
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0068 0.0059
Brugia malayi Papain family cysteine protease containing protein 0.028 0.1203 0.1994
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0046 0.0062
Plasmodium vivax histone deacetylase 2, putative 0.0704 0.3235 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0636 0.1113
Toxoplasma gondii exonuclease III APE 0.0039 0.0046 0.0062
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0065 0.0172 0.0505
Echinococcus multilocularis histone deacetylase 6 0.0704 0.3235 0.5395
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0509 0.2301 0.3803
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0142 0.0543 0.0938
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0321 0.1399 0.2322
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0159 0.0623 0.1872
Entamoeba histolytica calpain large subunit domain III containing protein 0.0045 0.0075 0.017
Giardia lamblia Cathepsin L precursor 0.0065 0.0172 0.0496
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Echinococcus multilocularis geminin 0.0353 0.1555 0.2592
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0135 0.0225
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0057 0.0132 0.0337
Brugia malayi Thioredoxin reductase 0.0038 0.0045 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0015 0.0015
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0321 0.1399 0.4334
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0057 0.0132 0.0166
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0057 0.0132 0.0132
Brugia malayi hypothetical protein 0.0487 0.2196 0.3652
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0167 0.0226
Brugia malayi hypothetical protein 0.019 0.0774 0.1278
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.0353
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0134 0.0504 0.0818
Schistosoma mansoni hypothetical protein 0.0145 0.0557 0.0557
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0033 0.0054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.028 0.1203 0.1994
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0177 0.071 0.071
Plasmodium falciparum plasmepsin III 0.019 0.0774 0.2372
Echinococcus granulosus acylamino acid releasing enzyme 0.0134 0.0504 0.0841
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0132 0.0315
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0509 0.2301 0.425
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0203 0.0339
Trypanosoma cruzi histone deacetylase, putative 0.0289 0.1247 0.2036
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0321 0.1399 0.2334
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0693 0.3186 0.3186
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0221 0.0353
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0065 0.0172 0.0172
Schistosoma mansoni cathepsin C 0.0065 0.0172 0.0172
Echinococcus granulosus importin subunit beta 1 0.0031 0.0009 0.0015
Trypanosoma cruzi cysteine proteinase, putative 0.0152 0.059 0.0935
Leishmania major hypothetical protein, conserved 0.0057 0.0132 0.0166
Mycobacterium tuberculosis Conserved protein 0.0075 0.0221 0.0331
Loa Loa (eye worm) inositol-1 0.0159 0.0623 0.1025
Onchocerca volvulus Cathepsin L homolog 0.028 0.1203 0.1987
Schistosoma mansoni ap endonuclease 0.0039 0.0046 0.0046
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0057 0.0132 0.0166
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0693 0.3186 0.5313
Echinococcus multilocularis cpg binding protein 0.0064 0.0169 0.0282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0172 0.0172
Echinococcus multilocularis histone deacetylase 7 0.0704 0.3235 0.5395
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0167 0.0264
Echinococcus granulosus BRCA1 associated protein 0.0057 0.0132 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0172 0.0443
Brugia malayi histone deacetylase 3 (HD3) 0.0567 0.2579 0.4291
Echinococcus granulosus glycoprotein Antigen 5 0.0032 0.0015 0.0025
Echinococcus multilocularis histone deacetylase 1 0.0567 0.2579 0.43
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.059 0.2193
Brugia malayi Histone deacetylase family protein 0.0704 0.3235 0.5388
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.1333 0.218
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0065 0.0172 0.0443
Trypanosoma cruzi cysteine peptidase, putative 0.0152 0.059 0.0935
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0032 0.0053
Schistosoma mansoni histone deacetylase 1 2 3 0.0289 0.1247 0.1247
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0509 0.2301 0.9088
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0057 0.0132 0.038
Echinococcus granulosus histone deacetylase 6 0.076 0.3506 0.5847
Trypanosoma cruzi histone deacetylase, putative 0.0704 0.3235 0.5369
Plasmodium falciparum cysteine proteinase falcipain 1 0.0152 0.059 0.1801
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0967 0.16
Trypanosoma cruzi histone deacetylase, putative 0.0704 0.3235 0.5369
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.0172 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.028 0.1203 0.3713
Trypanosoma cruzi oligopeptidase b 0.0509 0.2301 0.3803
Brugia malayi eukaryotic initiation factor 4A 0.0321 0.1399 0.2322
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0246 0.1042 0.1693
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0065 0.0172 0.0505
Giardia lamblia Hypothetical protein 0.0065 0.0172 0.0496
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0132 0.0315
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0057 0.0132 0.0205
Trypanosoma brucei prolyl endopeptidase 0.1279 0.5997 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0328 0.0466
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0249 0.0362
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Plasmodium vivax aspartyl protease, putative 0.0436 0.1951 0.6021
Entamoeba histolytica cysteine proteinase, putative 0.028 0.1203 0.46
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0228 0.0952 0.0952
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0132 0.038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0247 0.1047 0.1745
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0134 0.0504 0.0827
Brugia malayi cathepsin Z-like cysteine proteinase 0.0065 0.0172 0.0272
Plasmodium vivax histone deacetylase 1, putative 0.0567 0.2579 0.7966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0172 0.0443
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0321 0.1399 0.1399
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0591 0.2695 0.2695
Schistosoma mansoni neprilysin 0.0145 0.0557 0.0557
Schistosoma mansoni cathepsin F (C01 family) 0.028 0.1203 0.1203
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0279 0.045
Echinococcus granulosus histone deacetylase 0.0704 0.3235 0.5395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.1047 0.1047
Loa Loa (eye worm) zinc metallopeptidase 4 0.0136 0.0511 0.0838
Schistosoma mansoni calpain C (C02 family) 0.0064 0.0167 0.0167
Echinococcus granulosus geminin 0.0353 0.1555 0.2592
Echinococcus granulosus cpg binding protein 0.0064 0.0169 0.0282
Plasmodium vivax unspecified product 0.0152 0.059 0.1801
Brugia malayi Trypsin family protein 0.0121 0.0441 0.0721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.1461 0.2424
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Entamoeba histolytica cysteine protease, putative 0.0152 0.059 0.2193
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0567 0.2579 0.8074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0057 0.0095
Echinococcus multilocularis cathepsin l cysteine peptidase 0.028 0.1203 0.2007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0167 0.0226
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0046 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0221 0.0221

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3 uM In vitro inhibition of ADP-induced aggregation of human PRP in the presence of pig aortal microsomes (PAM). ChEMBL. 1311763
IC50 (functional) = 3 uM In vitro inhibition of ADP-induced aggregation of human PRP in the presence of pig aortal microsomes (PAM). ChEMBL. 1311763
IC50 (functional) = 49 uM Inhibition of ADP-induced aggregation of human PRP in the absence of pig aortal microsomes (PAM) ChEMBL. 1311763
IC50 (functional) = 49 uM Inhibition of ADP-induced aggregation of human PRP in the absence of pig aortal microsomes (PAM) ChEMBL. 1311763
Ratio (functional) = 167 Ratio of IC50(w/oPAM)/IC50(w/PAM) ChEMBL. 1311763

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 1311763

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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