Detailed information for compound 27318

Basic information

Technical information
  • TDR Targets ID: 27318
  • Name: [2,6-di(propan-2-yl)phenyl] N-[2,6-di(propan- 2-yl)phenoxy]sulfonylcarbamate
  • MW: 461.614 | Formula: C25H35NO5S
  • H donors: 1 H acceptors: 3 LogP: 7.44 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NS(=O)(=O)Oc1c(cccc1C(C)C)C(C)C)Oc1c(cccc1C(C)C)C(C)C
  • InChi: 1S/C25H35NO5S/c1-15(2)19-11-9-12-20(16(3)4)23(19)30-25(27)26-32(28,29)31-24-21(17(5)6)13-10-14-22(24)18(7)8/h9-18H,1-8H3,(H,26,27)
  • InChiKey: MHCQGCLTFBMETG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,6-diisopropylphenyl) N-(2,6-diisopropylphenoxy)sulfonylcarbamate
  • N-(2,6-diisopropylphenoxy)sulfonylcarbamic acid (2,6-diisopropylphenyl) ester
  • ((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester
  • 142642-31-7
  • PD 138142
  • PD-138142
  • 2,6-Bis(1-methylethyl)phenyl ((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamate
  • Bis(2,6-mepo)-cns
  • Carbamic acid, ((2,6-bis(1-methylethyl)phenoxy)sulfonyl)-, 2,6-bis(1-methylethyl)phenyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0097 0.0072 0.0072
Plasmodium falciparum phosphodiesterase gamma, putative 0.0326 0.0262 1
Toxoplasma gondii aminopeptidase N, putative 0.0061 0.0042 0.0192
Loa Loa (eye worm) hypothetical protein 0.0238 0.0189 0.0189
Onchocerca volvulus 0.0144 0.0111 0.2172
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0013 0.0046
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0008 0.0252
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.1231 0.1011 0.3607
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0061 0.0042 0.0151
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0019 0.0066
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0008 0.0012
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0268
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0008 0.0288
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0326 0.0262 1
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0013 0.0046
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0071 0.007
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0013 0.002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Echinococcus multilocularis expressed conserved protein 0.009 0.0066 0.0102
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0326 0.0262 0.0407
Leishmania major hypothetical protein, conserved 0.0026 0.0013 0.0436
Schistosoma mansoni protein kinase C mu 0.001 0 0.0001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Leishmania major cAMP-specific phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0008 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0006 0.0021
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0061 0.0042 0.1614
Trichomonas vaginalis MYB, putative 0.0019 0.0007 0.0271
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0071 0.0109
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0035 0.1318
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0029 0.0029
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0013 0.0013
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0013 0.0046
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0006 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0006 0.0021
Echinococcus granulosus endothelin converting enzyme 1 0.1231 0.1011 0.1571
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0007 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0006 0.0006
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0061 0.0042 0.1569
Brugia malayi ecdysteroid receptor 0.0017 0.0006 0.0006
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0043
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0008 0.0288
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0061 0.0042 0.1619
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Trypanosoma brucei aminopeptidase, putative 0.0061 0.0042 0.1569
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Brugia malayi RhoGAP domain containing protein 0.0062 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0039
Leishmania major DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.001 0 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0035 0.1271
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0012
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0326 0.0262 0.0935
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0008 0.0235
Echinococcus multilocularis aminopeptidase N 0.0061 0.0042 0.0066
Trypanosoma cruzi aminopeptidase, putative 0.0061 0.0042 0.1569
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0019 0.0653
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0144 0.0111 0.0173
Schistosoma mansoni glutaminase 0.0268 0.0214 0.0763
Toxoplasma gondii microneme protein MIC2 0.0144 0.0111 0.0503
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0006 0.0009
Trichomonas vaginalis set domain proteins, putative 0.023 0.0182 0.6935
Brugia malayi MH2 domain containing protein 0.0011 0.0001 0.0001
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0013 0.002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0025 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0105 0.0162
Loa Loa (eye worm) hypothetical protein 0.0909 0.0745 0.0745
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0008 0.0293
Echinococcus granulosus tumor protein p63 0.0332 0.0266 0.0413
Brugia malayi topoisomerase 0.0019 0.0008 0.0008
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0007 0.0644
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0008 0.0008
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0019 0.0653
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Echinococcus granulosus geminin 0.0866 0.0709 0.1102
Echinococcus multilocularis endothelin converting enzyme 1 0.1231 0.1011 0.1571
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0061 0.0042 0.0405
Brugia malayi nuclear hormone receptor 0.0017 0.0006 0.0006
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0326 0.0262 1
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0013 0.0493
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1155 0.0949 0.0949
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni endothelin-converting enzyme-related 0.03 0.024 0.0856
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0061 0.0042 0.1569
Brugia malayi Pax transcription factor protein 2 0.0233 0.0185 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.0262 1
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0008 0.0235
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0035
Brugia malayi hypothetical protein 0.0119 0.009 0.009
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0326 0.0262 1
Echinococcus multilocularis protein patched 0.0041 0.0025 0.0039
Echinococcus multilocularis p2X purinoceptor 4 0.0213 0.0168 0.0261
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.005 0.0179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0029 0.0044
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0013 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0035 0.1318
Brugia malayi isocitrate dehydrogenase 0.0033 0.0019 0.0018
Trypanosoma brucei Aminopeptidase M1, putative 0.0061 0.0042 0.1569
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0006 0.0009
Trypanosoma brucei Aminopeptidase M1, putative 0.0061 0.0042 0.1569
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0013 0.0058
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0008 0.0035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0006 0.0021
Onchocerca volvulus 0.0144 0.0111 0.2172
Trichomonas vaginalis MYB72, putative 0.0019 0.0007 0.0268
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.0185 0.0185
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1231 0.1011 0.1011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0007 0.0007
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0008 0.069
Schistosoma mansoni DNA polymerase eta 0.0045 0.0028 0.0102
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0621 0.0506 0.1805
Brugia malayi Cytochrome P450 family protein 0.0012 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0326 0.0262 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0029 0.0103
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0013 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0008 0.0305
Trichomonas vaginalis MYB3r3, putative 0.0019 0.0007 0.0268
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0038
Schistosoma mansoni P2X receptor subunit 0.0213 0.0168 0.0599
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0017 0.0026
Giardia lamblia Hypothetical protein 0.0326 0.0262 0.1155
Brugia malayi DKFZp564C0469 protein 0.0019 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0321 0.0258 0.0919
Brugia malayi hypothetical protein 0.0061 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.061 0.0497 0.0497
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0008 0.0252
Echinococcus multilocularis Smad4 0.0025 0.0012 0.0019
Entamoeba histolytica hypothetical protein, conserved 0.0144 0.0111 1
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0144 0.0111 0.0111
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0007 0.028
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0013 0.0046
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0006 0.0006
Leishmania major DNA polymerase eta, putative 0.0045 0.0028 0.1034
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0144 0.0111 0.0503
Loa Loa (eye worm) hypothetical protein 0.0931 0.0763 0.0763
Echinococcus granulosus dna polymerase eta 0.0045 0.0028 0.0044
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0015 0.0015
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Treponema pallidum 76K protein 0.0144 0.0111 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0006 0.0006
Echinococcus multilocularis geminin 0.0866 0.0709 0.1102
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0008 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0025 0.0967
Schistosoma mansoni smad 0.0011 0.0001 0.0003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0029 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.001 0 0.0001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0288
Trypanosoma cruzi Aminopeptidase M1, putative 0.0061 0.0042 0.1569
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0029 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0006 0.0006
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.2682 0.2213 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0288
Brugia malayi Hhat protein 0.0026 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0071 0.005 0.0179
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0326 0.0262 0.0407
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0071 0.0109
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0006 0.0111
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0013 0.116
Brugia malayi von Willebrand Factor 0.0144 0.0111 0.0111
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.03 0.024 0.0856
Entamoeba histolytica hypothetical protein 0.0071 0.005 0.4505
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0011
Brugia malayi Peptidase family M1 containing protein 0.0061 0.0042 0.0042
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0035 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0016 0.0055
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0326 0.0262 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0008 0.0288
Leishmania major hypothetical protein, conserved 0.0326 0.0262 1
Schistosoma mansoni P2X receptor subunit 0.0213 0.0168 0.0599
Brugia malayi RhoGAP domain containing protein 0.0072 0.0051 0.0051
Schistosoma mansoni DNA helicase recq5 0.002 0.0008 0.0029
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0061 0.0042 0.1569
Brugia malayi hypothetical protein 0.0071 0.005 0.005
Echinococcus granulosus leukotriene A 4 hydrolase 0.1155 0.0949 0.1474
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0006 0.0006
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0006 0.0111
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0013 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0013 0.0436
Brugia malayi hypothetical protein 0.0144 0.0111 0.0111
Schistosoma mansoni P2X receptor subunit 0.0213 0.0168 0.0599
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0008 0.0035
Schistosoma mansoni hypothetical protein 0.1827 0.1505 0.5371
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0013 0.116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0016 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0038
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0013 0.002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi MBOAT family protein 0.0026 0.0013 0.0013
Schistosoma mansoni patched 1 0.0041 0.0025 0.0091
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0326 0.0262 0.0262
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0006 0.0021
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0013 0.002
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0003 0.0011
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.03 0.024 0.0856
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0144 0.0111 0.4243
Entamoeba histolytica hypothetical protein 0.0144 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0909 0.0745 0.0745
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.1231 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0628 0.0512 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0006 0.0006
Entamoeba histolytica elongation factor-2 kinase, putative 0.0144 0.0111 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0008 0.0288
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0012
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.1231 0.1011 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.7779 0.6436 1
Schistosoma mansoni coup transcription factor 0.0017 0.0006 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0017 0.0026
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0019 0.0029
Loa Loa (eye worm) hhat protein 0.0026 0.0013 0.0013
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Brugia malayi hypothetical protein 0.0052 0.0035 0.0035
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0015 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0013 0.0487
Schistosoma mansoni Smad4 0.0011 0.0001 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.005 0.0078
Loa Loa (eye worm) zinc metallopeptidase 4 0.03 0.024 0.024
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.0262 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0227
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0087
Toxoplasma gondii aminopeptidase N protein 0.0061 0.0042 0.0192
Schistosoma mansoni atypical protein kinase C 0.001 0 0.0001
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0006 0.0009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0072 0.0256
Brugia malayi CHE-14 protein 0.0041 0.0025 0.0025
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0061 0.0042 0.1614
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0025 0.0039
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0013 0.0046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0016 0.0024
Onchocerca volvulus 0.0019 0.0008 0.0147
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus granulosus GPCR family 2 0.0031 0.0017 0.0026
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0008 0.0288
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0006 0.0009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2682 0.2213 0.3439
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0035 0.1323
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0072 0.0071
Schistosoma mansoni neprilysin-2 (M13 family) 0.0621 0.0506 0.1805
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0001 0.0001
Leishmania major glycerol uptake protein, putative 0.0026 0.0013 0.0436
Trypanosoma cruzi GUP1, putative 0.0026 0.0013 0.0436
Schistosoma mansoni hypothetical protein 0.0279 0.0223 0.0795
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0008 0.0008
Schistosoma mansoni aminopeptidase A (M01 family) 0.0061 0.0042 0.0151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.2682 0.2213 1
Schistosoma mansoni topbp1 0.0019 0.0008 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.005 0.0078
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0013 0.002
Onchocerca volvulus Huntingtin homolog 0.0119 0.009 0.1755
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0012 0.0012
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0013 0.0436
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0015 0.0053
Brugia malayi hypothetical protein 0.0531 0.0432 0.0431
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Echinococcus multilocularis GPCR, family 2 0.0031 0.0017 0.0026
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0012
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0008 0.0235
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0001 0.0001
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0019 0.0007 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.0262 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0035 0.1271
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0015 0.0023
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0326 0.0262 0.0407
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0008 0.0027
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0008 0.0235
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0031 0.0017 0.006
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0013 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0268
Brugia malayi hypothetical protein 0.0628 0.0512 0.0511
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Trichomonas vaginalis C-MYB, putative 0.0019 0.0007 0.0268
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni DNA ligase IV 0.0019 0.0008 0.0027
Schistosoma mansoni hypothetical protein 0.0866 0.0709 0.2531
Echinococcus granulosus microtubule associated protein 2 0.0669 0.0546 0.0847
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0326 0.0262 0.0407
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0008 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0017 0.0026
Brugia malayi Protein kinase domain containing protein 0.001 0 0.0000092113
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0006 0.0006
Plasmodium vivax thrombospondin-related anonymous protein 0.0144 0.0111 0.4246
Loa Loa (eye worm) PDE1B protein 0.0326 0.0262 0.0262
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0012 0.0043
Brugia malayi hypothetical protein 0.0034 0.0019 0.0019
Onchocerca volvulus 0.061 0.0497 0.9707
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Onchocerca volvulus 0.0233 0.0185 0.361
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0013 0.0436
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.021 0.0326
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0071 0.6346
Onchocerca volvulus 0.023 0.0182 0.3554
Schistosoma mansoni hypothetical protein 0.0321 0.0258 0.0919
Plasmodium vivax phosphodiesterase gamma, putative 0.0326 0.0262 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0008 0.0235
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0019 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0006 0.0009
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1711 0.1409 0.5026
Loa Loa (eye worm) hypothetical protein 0.0061 0.0042 0.0042
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Trypanosoma brucei hypothetical protein, conserved 0.0326 0.0262 1
Echinococcus multilocularis protein dispatched 1 0.0047 0.003 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0016 0.0055
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0013 0.0436
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0006 0.0021
Schistosoma mansoni brg-1 associated factor 0.001 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0262 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0007 0.028
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0007 0.0007
Brugia malayi hypothetical protein 0.0019 0.0008 0.0008
Onchocerca volvulus 0.0061 0.0042 0.0826
Schistosoma mansoni hypothetical protein 0.0026 0.0013 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0019 0.0029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0019 0.0029
Mycobacterium ulcerans glutaminase 0.0268 0.0214 0.2102
Brugia malayi protein kinase C II. 0.001 0 0.0000092113
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0087
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0326 0.0262 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0326 0.0262 0.0262
Entamoeba histolytica hypothetical protein 0.0026 0.0013 0.116
Loa Loa (eye worm) hypothetical protein 0.0119 0.009 0.009
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0008 0.0305
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0001 0.0001
Schistosoma mansoni serine-rich repeat protein 0.1827 0.1505 0.5371
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0018 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0006 0.0006
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0025 0.0039
Entamoeba histolytica aminopeptidase, putative 0.0061 0.0042 0.3812
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0061 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0017
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0326 0.0262 1
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0028 0.1034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0013 0.002
Loa Loa (eye worm) RecQ helicase 0.002 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0061 0.0042 0.0151
Trypanosoma cruzi aminopeptidase, putative 0.0061 0.0042 0.1569
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0008 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Brugia malayi Pre-SET motif family protein 0.0029 0.0016 0.0015
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0144 0.0111 0.4243
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0326 0.0262 0.0407
Loa Loa (eye worm) hypothetical protein 0.0264 0.021 0.021
Trypanosoma brucei unspecified product 0.0019 0.0007 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0019 0.0029
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0326 0.0262 0.0262
Echinococcus multilocularis bloom syndrome protein 0.002 0.0008 0.0012
Echinococcus granulosus p2X purinoceptor 4 0.0213 0.0168 0.0261
Brugia malayi MBOAT family protein 0.0026 0.0013 0.0013
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0909 0.0745 0.0745
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0326 0.0262 0.0407
Schistosoma mansoni hypothetical protein 0.0321 0.0258 0.0919
Toxoplasma gondii hypothetical protein 0.0026 0.0013 0.0058
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0061 0.0042 0.1569
Brugia malayi protein kinase C3,putative 0.001 0 0.0000092113
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0326 0.0262 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0262 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0015 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Loa Loa (eye worm) Smad1 0.0025 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.001 0 0.0001
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0061 0.0042 0.0066
Schistosoma mansoni hypothetical protein 0.0321 0.0258 0.0919
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0013 0.116
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0931 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0271
Echinococcus granulosus expressed conserved protein 0.009 0.0066 0.0102
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0262 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0013 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0029 0.0029
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0008 0.0008
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0006 0.0006
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0326 0.0262 0.0407
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0144 0.0111 0.4246
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0017 0.0017
Brugia malayi MBOAT family protein 0.0026 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0029 0.0015 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0019 0.0084
Entamoeba histolytica hypothetical protein 0.0071 0.005 0.4505
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0011 0.0017
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0326 0.0262 0.0262
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0043
Plasmodium falciparum thrombospondin-related anonymous protein 0.0144 0.0111 0.4243
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0006 0.0021
Brugia malayi steroid hormone receptor 0.0017 0.0006 0.0006
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.001 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.001 0 0.0001
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0013 0.0487
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Echinococcus granulosus nibrin 0.0019 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0002 0.0002
Brugia malayi Uncoordinated protein 44 0.0028 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.001 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0326 0.0262 0.0262
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0008 0.0305
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2682 0.2213 0.3439
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0017 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0006 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0013 0.116
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0028
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0061 0.0042 0.1619
Trichomonas vaginalis glutaminase, putative 0.0268 0.0214 0.8159
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0268
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0008 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0006 0.0021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0019 0.0029
Plasmodium vivax SET domain protein, putative 0.0029 0.0016 0.0592
Echinococcus multilocularis nibrin 0.0019 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0032 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3538 0.2922 0.4541
Brugia malayi Pre-SET motif family protein 0.0202 0.0159 0.0158
Plasmodium vivax hypothetical protein, conserved 0.001 0 0.0006
Onchocerca volvulus 0.0144 0.0111 0.2172
Onchocerca volvulus 0.0029 0.0016 0.0301
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Giardia lamblia hypothetical protein 0.0326 0.0262 0.1155
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0015 0.0023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0016 0.0024
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi TATA binding protein associated factor 0.0061 0.0042 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0006 0.0006
Mycobacterium ulcerans aminopeptidase N PepN 0.0061 0.0042 0.0405
Brugia malayi hypothetical protein 0.0019 0.0008 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0029 0.0103
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0015 0.0023
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0013 0.0436
Loa Loa (eye worm) nuclear factor I 0.0014 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0866 0.0709 0.2531
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Onchocerca volvulus 0.0628 0.0512 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0326 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0061 0.0042 0.0042
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0105 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0288
Loa Loa (eye worm) hypothetical protein 0.0931 0.0763 0.0763
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Echinococcus granulosus dna polymerase kappa 0.0019 0.0007 0.0011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0326 0.0262 0.0407
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Onchocerca volvulus 0.0049 0.0032 0.0618
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0006 0.0006
Echinococcus granulosus p2X purinoceptor 4 0.0213 0.0168 0.0261
Plasmodium vivax hypothetical protein, conserved 0.0144 0.0111 0.4246
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0071 0.005 0.4505
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.0294 0.0294
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0007 0.0227
Loa Loa (eye worm) hypothetical protein 0.0072 0.0051 0.0051
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.2682 0.2213 0.7896
Entamoeba histolytica hypothetical protein, conserved 0.0144 0.0111 1
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0006 0.0009
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Loa Loa (eye worm) hypothetical protein 0.1566 0.1289 0.1289
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.0294 0.0294
Brugia malayi Protein kinase c protein 2 0.001 0 0.0000092113
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0144 0.0111 0.4246
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Onchocerca volvulus 0.0144 0.0111 0.2172
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0007 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0006 0.0009
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni smad 0.0025 0.0012 0.0043
Onchocerca volvulus 0.0144 0.0111 0.2172
Chlamydia trachomatis DNA ligase 0.0019 0.0008 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Schistosoma mansoni hypothetical protein 0.0028 0.0015 0.0053
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0326 0.0262 0.0935
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0013 0.116
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0012 0.0019
Loa Loa (eye worm) CUTiclin-Like family member 0.0144 0.0111 0.0111
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0007 0.0672
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0007 0.0644
Leishmania major glycerol uptake protein, putative 0.0026 0.0013 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.0262 1
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.0007 0.0268
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0326 0.0262 0.0407
Brugia malayi von Willebrand factor type A domain containing protein 0.0144 0.0111 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.0262 1
Loa Loa (eye worm) glutaminase 2 0.0268 0.0214 0.0214
Loa Loa (eye worm) glutaminase 0.0268 0.0214 0.0214
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0008 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0006 0.0021
Echinococcus granulosus nuclear factor of activated T cells 5 0.043 0.0348 0.0541
Giardia lamblia DINP protein human, muc B family 0.0019 0.0007 0.0001
Toxoplasma gondii peptidase family M13 protein 0.1231 0.1011 0.4568
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0012 0.0019
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0144 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0043
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0012 0.0019
Echinococcus granulosus Ankyrin 0.0028 0.0015 0.0023
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0018 0.0612
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0061 0.0042 0.1569
Echinococcus granulosus bloom syndrome protein 0.002 0.0008 0.0012
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.0007 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0031 0.0017 0.006
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0007 0.0644
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0326 0.0262 1
Brugia malayi Death domain containing protein 0.0028 0.0015 0.0015
Schistosoma mansoni topbp1 0.0019 0.0008 0.0027
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2355 0.1943 0.3018
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0326 0.0262 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0019 0.0709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0072 0.0071
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.069
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.03 0.024 0.0856
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi MBOAT family protein 0.0026 0.0013 0.0013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0006 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0006 0.0009
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0025 0.0039
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0061 0.0042 0.1614
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0013
Mycobacterium ulcerans zinc metalloprotease 0.1231 0.1011 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0288
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0011
Loa Loa (eye worm) peptidase family M13 containing protein 0.0909 0.0745 0.0745
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0019 0.0008 0.5
Brugia malayi Peptidase family M1 containing protein 0.0061 0.0042 0.0042
Echinococcus multilocularis smad 0.0025 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0008 0.0012
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0019 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0033 0.0033
Entamoeba histolytica recQ family helicase, putative 0.002 0.0008 0.073
Mycobacterium leprae probable zinc metalloprotease 0.1231 0.1011 1
Leishmania major hypothetical protein, conserved 0.0052 0.0035 0.1271
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0268
Leishmania major DNA polymerase eta, putative 0.0031 0.0018 0.0612
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0038
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.001 0 0.0000092113
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0007 0.0027
Brugia malayi Peptidase family M1 containing protein 0.0061 0.0042 0.0042
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.0546 0.0847
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0072 0.0072
Giardia lamblia Rho GAP, putative 0.0062 0.0043 0.0163
Treponema pallidum DNA ligase (lig) 0.0019 0.0008 0.069
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0013 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0035 0.1271
Brugia malayi Smad1 0.0025 0.0012 0.0012
Giardia lamblia Replication factor C, subunit 1 0.0019 0.0008 0.0002
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.3394 0.2803 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0013 0.0436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0006 0.0006
Echinococcus granulosus voltage dependent calcium channel subunit 0.3538 0.2922 0.4541
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0038
Brugia malayi peptidase family M13 containing protein 0.03 0.024 0.024
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0028 0.1034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0019 0.0704
Loa Loa (eye worm) hypothetical protein 0.0066 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0487
Echinococcus multilocularis Rac GTPase activating protein 1 0.0072 0.0051 0.008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0015 0.0023
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0032 0.0113
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0144 0.0111 0.4246
Schistosoma mansoni Smad4 0.0011 0.0001 0.0003
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0013 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0006 0.0009
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0061 0.0042 0.1569
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0046 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.0546 0.1946
Schistosoma mansoni hypothetical protein 0.0031 0.0017 0.006
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0144 0.0111 0.4243
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0028 0.0028
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0621 0.0506 0.1805
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1604 0.132 0.2051
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0007 0.0011
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0013 0.002
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.1231 0.1011 0.1011
Schistosoma mansoni hypothetical protein 0.001 0 0.0001
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0013 0.002
Loa Loa (eye worm) TATA binding protein associated factor 0.0061 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Brugia malayi Immunoglobulin I-set domain containing protein 0.0144 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0061 0.0042 0.0042
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0007 0.0644
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0007 0.0644
Schistosoma mansoni hypothetical protein 0.0066 0.0046 0.0165
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0008 0.0008
Schistosoma mansoni rac gtpase activating protein 0.0072 0.0051 0.0183
Echinococcus multilocularis Ankyrin 0.0028 0.0015 0.0023
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0008 0.0305
Trypanosoma cruzi GUP1, putative 0.0026 0.0013 0.0436
Brugia malayi C1-like domain containing protein 0.001 0 0.0000092113
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0013 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0016 0.0055
Trichomonas vaginalis C-MYB, putative 0.0019 0.0007 0.0268
Loa Loa (eye worm) hhat protein 0.0026 0.0013 0.0013
Echinococcus granulosus death domain containing protein 0.0028 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.03 0.024 0.0856
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0144 0.0111 0.0397
Brugia malayi Cytochrome P450 family protein 0.0012 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.0262 1
Brugia malayi MBOAT family protein 0.0026 0.0013 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0007 0.0059
Loa Loa (eye worm) peptidase family M1 containing protein 0.0061 0.0042 0.0042
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.001 0 0.0001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0621 0.0506 0.1805
Onchocerca volvulus 0.0061 0.0042 0.0826
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0487
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0013 0.0058
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0015 0.0286
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0006 0.0021
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni serine/threonine protein kinase 0.001 0 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0006 0.0009
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0326 0.0262 0.0407
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0326 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.1231 0.1011 0.1011
Onchocerca volvulus 0.0061 0.0042 0.0826
Loa Loa (eye worm) hypothetical protein 0.0119 0.009 0.009
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0931 0.0763 0.0763
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0012 0.0012
Schistosoma mansoni neprilysin 0.0321 0.0258 0.0919
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0019 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0019 0.0084
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0061 0.0042 0.1569
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0008 0.0037
Schistosoma mansoni DNA helicase recq1 0.002 0.0008 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0006 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0006 0.0009
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.03 0.024 0.0856
Entamoeba histolytica hypothetical protein 0.0071 0.005 0.4505
Leishmania major hypothetical protein, conserved 0.0326 0.0262 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2682 0.2213 0.3439
Echinococcus granulosus X box binding protein 1 0.0279 0.0223 0.0346
Toxoplasma gondii aminopeptidase n, putative 0.0061 0.0042 0.0192
Brugia malayi Zona pellucida-like domain containing protein 0.0144 0.0111 0.0111
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0015 0.0053
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0008 0.0288
Loa Loa (eye worm) CUTiclin family member 0.0144 0.0111 0.0111
Echinococcus granulosus p2X purinoceptor 4 0.0213 0.0168 0.0261
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0008 0.0305
Brugia malayi hypothetical protein 0.0061 0.0042 0.0042
Loa Loa (eye worm) peptidase family M13 containing protein 0.0909 0.0745 0.0745
Echinococcus multilocularis voltage dependent calcium channel subunit 0.7779 0.6436 1
Echinococcus granulosus smad 0.0025 0.0012 0.0019
Brugia malayi MH2 domain containing protein 0.0365 0.0294 0.0294
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0061 0.0042 0.1569
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0019 0.0111
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0013 0.002
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0006 0.0021
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0072 0.0051 0.008
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0061 0.0042 0.1614
Onchocerca volvulus Huntingtin homolog 0.0119 0.009 0.1755
Schistosoma mansoni zinc finger protein 0.0026 0.0013 0.0046
Schistosoma mansoni hypothetical protein 0.0144 0.0111 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0288
Echinococcus granulosus collagen alpha 1VII chain 0.0144 0.0111 0.0173
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0019 0.0653
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0326 0.0262 0.0262
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2355 0.1943 0.3018
Echinococcus multilocularis p2X purinoceptor 4 0.0213 0.0168 0.0261
Loa Loa (eye worm) hypothetical protein 0.0931 0.0763 0.0763
Echinococcus multilocularis dna polymerase eta 0.0045 0.0028 0.0044
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.2355 0.1943 0.1943
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0016 0.007
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Loa Loa (eye worm) hypothetical protein 0.0931 0.0763 0.0763
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0006 0.0006
Echinococcus multilocularis nuclear factor of activated T cells 5 0.043 0.0348 0.0541
Onchocerca volvulus 0.0144 0.0111 0.2172
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0621 0.0506 0.1805
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0006 0.0009
Brugia malayi nuclear receptor NHR-88 0.0017 0.0006 0.0006
Echinococcus multilocularis p2X purinoceptor 4 0.0213 0.0168 0.0261
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0326 0.0262 1
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0019 0.0008 0.0061
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0001 0.0001
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.021 0.075
Loa Loa (eye worm) hypothetical protein 0.0062 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0041 0.0025 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Schistosoma mansoni netrin receptor unc5 0.0028 0.0015 0.0053
Plasmodium falciparum phosphodiesterase delta, putative 0.0326 0.0262 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0227
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1155 0.0949 0.1474
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0144 0.0111 0.0111
Brugia malayi glutaminase DH11.1 0.0268 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0321 0.0258 0.0919
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0326 0.0262 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0006 0.0111
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0326 0.0262 0.0935
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1155 0.0949 0.3385
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0326 0.0262 0.0407
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0061 0.0042 0.1569
Loa Loa (eye worm) hypothetical protein 0.0095 0.0071 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0029 0.0044
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.001 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0002 0.0002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.2355 0.1943 0.1942
Loa Loa (eye worm) hypothetical protein 0.2682 0.2213 0.2213
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0326 0.0262 0.0407
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0326 0.0262 0.1184
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0001 0.0012
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0013 0.002
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0326 0.0262 0.0935
Schistosoma mansoni serine/threonine protein kinase 0.001 0 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Schistosoma mansoni P2X receptor subunit 0.0213 0.0168 0.0599
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0013 0.116
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0019 0.0653
Brugia malayi Cache domain containing protein 0.1566 0.1289 0.1289
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0061 0.0042 0.0066
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Echinococcus granulosus aminopeptidase N 0.0061 0.0042 0.0066
Echinococcus multilocularis X box binding protein 1 0.0279 0.0223 0.0346
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0007 0.0268
Onchocerca volvulus 0.0017 0.0006 0.0111
Brugia malayi Zona pellucida-like domain containing protein 0.0144 0.0111 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0061 0.0042 0.1614
Leishmania major glycerol uptake protein, putative 0.0026 0.0013 0.0436
Loa Loa (eye worm) angiotensin-converting enzyme family protein 1.2082 1 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0006 0.0021
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0019 0.0019
Echinococcus multilocularis tumor protein p63 0.0332 0.0266 0.0413
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0326 0.0262 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0008 0.0252
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0061 0.0042 0.1569
Loa Loa (eye worm) aminopeptidase N 0.0061 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0909 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0003
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0013 0.0013
Echinococcus granulosus Smad4 0.0025 0.0012 0.0019
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2682 0.2213 0.3439
Schistosoma mansoni hypothetical protein 0.0321 0.0258 0.0919
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0006 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0144 0.0111 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0227
Trichomonas vaginalis porcupine, putative 0.0026 0.0013 0.0487
Brugia malayi Peptidase family M13 containing protein 0.1231 0.1011 0.1011
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0008 0.0008
Schistosoma mansoni Smad4 0.0025 0.0012 0.0043
Onchocerca volvulus 0.0144 0.0111 0.2172
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0006 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0016 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0029 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0326 0.0262 1
Onchocerca volvulus 0.0026 0.0013 0.0249
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0321 0.0258 0.0919
Treponema pallidum hypothetical protein 0.0144 0.0111 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0227
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.021 0.0326
Schistosoma mansoni hypothetical protein 0.0031 0.0017 0.006
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0326 0.0262 1

Activities

Activity type Activity value Assay description Source Reference
Delta HDL (functional) = 345 % Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats ChEMBL. 8632431
Delta HDL (functional) = 345 % Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats ChEMBL. 8632431
Delta TC (functional) = -70 % Acute in vivo activity measured by total plasma cholesterol concentration levels (TC) at 30 mg/kg dose ChEMBL. 8632431
Delta TC (functional) = -68 % Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats ChEMBL. 8632431
Delta TC (functional) = -68 % Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats ChEMBL. 8632431
Delta TC (functional) = -54 % Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 3 mg/kg ChEMBL. 8632431
Delta TC (functional) = -54 % Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 3 mg/kg ChEMBL. 8632431
IC50 (binding) = 9.4 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431
IC50 (binding) = 9.4 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431
Unchanged (ADMET) = 23 % Solution Degradation Studies measured by compound unchanged at pH 0.4=50% 1 M HCl/50% acetonitrile at 24 hours ChEMBL. 8978833
Unchanged (ADMET) = 37 % Solution Degradation Studies measured by compound unchanged at pH 6.4=50%water/50%acetonitrile at 24 hours ChEMBL. 8978833
Unchanged (ADMET) = 66 % Solution Degradation Studies measured by compound unchanged at pH 0.4=50% 1 M HCl/50% acetonitrile at 8 hours ChEMBL. 8978833
Unchanged (ADMET) = 74 % Solution Degradation Studies measured by compound unchanged at pH 6.4=50%water/50%acetonitrile at 8 hours ChEMBL. 8978833
Unchanged (ADMET) = 80 % Solution Degradation Studies measured by compound unchanged at pH 0.4=50% 1 M HCl/50% acetonitrile at 4 hours ChEMBL. 8978833
Unchanged (ADMET) = 85 % Solution Degradation Studies measured by compound unchanged at pH 6.4=50%water/50%acetonitrile at 4 hours ChEMBL. 8978833
Unchanged (ADMET) = 87 % Solution Degradation Studies measured by compound unchanged at pH 6.4=50%water/50%acetonitrile at 2 hours ChEMBL. 8978833
Unchanged (ADMET) = 88 % Solution Degradation Studies measured by compound unchanged at pH 0.4=50% 1 M HCl/50% acetonitrile at 2 hours ChEMBL. 8978833
Unchanged (ADMET) = 95 % Solution Degradation Studies measured by compound unchanged at pH 0.4=50% 1 M HCl/50% acetonitrile at 0 hours ChEMBL. 8978833
Unchanged (ADMET) = 95 % Solution Degradation Studies measured by compound unchanged at pH 6.4=50%water/50%acetonitrile at 0 hours ChEMBL. 8978833

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.