Detailed information for compound 303277

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 234.725 | Formula: C13H15ClN2
  • H donors: 1 H acceptors: 1 LogP: 2.48 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ncc2c(c1)CCC1C2C2CCC1N2
  • InChi: 1S/C13H15ClN2/c14-12-5-7-1-2-8-10-3-4-11(16-10)13(8)9(7)6-15-12/h5-6,8,10-11,13,16H,1-4H2
  • InChiKey: HYHQVGSPVWWXJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Neuronal acetylcholine receptor; alpha3/beta2   500 aa 486 aa 24.3 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta2   500 aa 463 aa 36.1 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 492 aa 39.8 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 502 aa 34.7 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 463 aa 36.1 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 532 aa 24.2 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta2   500 aa 477 aa 39.2 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 487 aa 34.3 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 510 aa 38.6 %
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 Neuronal acetylcholine receptor; alpha3/beta4   499 aa 569 aa 25.5 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha2/beta4   495 aa 502 aa 40.0 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor; alpha3/beta4   499 aa 538 aa 24.9 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta2   500 aa 500 aa 33.8 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta4   499 aa 549 aa 24.0 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Neuronal acetylcholine receptor; alpha2/beta4   495 aa 501 aa 23.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 516 aa 42.1 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 481 aa 38.0 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 524 aa 38.7 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Neuronal acetylcholine receptor; alpha3/beta2   500 aa 511 aa 40.9 %
Loa Loa (eye worm) hypothetical protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 521 aa 40.1 %
Brugia malayi Cation transporter family protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 482 aa 32.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 482 aa 42.5 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 507 aa 37.9 %
Onchocerca volvulus Putative zinc finger protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 509 aa 40.3 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Neuronal acetylcholine receptor; alpha3/beta4   499 aa 569 aa 25.8 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Neuronal acetylcholine receptor; alpha3/beta2   500 aa 476 aa 41.4 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor; alpha3/beta4   499 aa 546 aa 26.0 %
Echinococcus multilocularis nAChR subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 476 aa 30.3 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 491 aa 37.7 %
Echinococcus granulosus acetylcholine receptor subunit beta 1 Neuronal acetylcholine receptor; alpha3/beta4   499 aa 523 aa 35.9 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 508 aa 34.3 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 482 aa 42.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0007 0.0023
Schistosoma mansoni rab6-interacting 0.0021 0.0016 0.0037
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Brugia malayi conserved hypotetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0007 0.0017
Brugia malayi nuclear hormone receptor 0.0039 0.0075 0.0262
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0108 0.0301 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0075 0.0262
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0068 0.0169 0.0169
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0139 0.3783
Echinococcus granulosus bloom syndrome protein 0.0044 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0082 0.0082
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0082 0.0287
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0068 0.0169 0.0592
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Echinococcus granulosus slit 2 protein 0.0054 0.0123 0.0123
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0061 0.0743
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0179 0.0626
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0009 0.0017
Brugia malayi hypothetical protein 0.0256 0.0782 0.2737
Toxoplasma gondii kringle domain-containing protein 0.0026 0.0031 0.0372
Schistosoma mansoni ap endonuclease 0.0059 0.0139 0.032
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Brugia malayi PXA domain containing protein 0.0041 0.0082 0.0287
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0075 0.0075
Onchocerca volvulus 0.009 0.0239 0.0733
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0078 0.0078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0075 0.0262
Schistosoma mansoni hypothetical protein 0.0026 0.0031 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Onchocerca volvulus 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Onchocerca volvulus 0.0017 0.0001 0.0004
Echinococcus granulosus metabotropic glutamate receptor 5 0.0117 0.033 0.033
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0057 0.0134 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0082 0.0189
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.0428 0.0428
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0249 0.0759 0.2656
Echinococcus granulosus intermediate filament protein 0.009 0.0239 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0367 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0075 0.0262
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0075 0.0173
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0107 0.0296 0.0296
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0209 0.6121
Loa Loa (eye worm) ACC-1 protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0289
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0075 0.0229
Schistosoma mansoni DNA helicase recq5 0.003 0.0047 0.0108
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0079 0.0206 0.0476
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0428 0.1499
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0082 0.0082
Schistosoma mansoni neurotransmitter gated ion channel 0.0079 0.0206 0.0476
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Schistosoma mansoni loxhd1 0.0021 0.0016 0.0037
Schistosoma mansoni hypothetical protein 0.0057 0.0134 0.0309
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Toxoplasma gondii microneme protein MIC2 0.0057 0.0134 0.1621
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0051 0.0616
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0075 0.0262
Echinococcus multilocularis RUN 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0107 0.0296 0.1035
Schistosoma mansoni cell polarity protein 0.0054 0.0123 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0229
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0331 0.3942
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0428 0.0989
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0082 0.0189
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0057 0.0134 0.6411
Schistosoma mansoni hypothetical protein 0.0439 0.1379 0.3183
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0054 0.0123 0.0431
Onchocerca volvulus 0.0057 0.0134 0.0411
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0075 0.0075
Schistosoma mansoni rotamase 0.0036 0.0064 0.0148
Loa Loa (eye worm) DR-78 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0331 0.0994
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0331 0.1158
Schistosoma mansoni hypothetical protein 0.0024 0.0025 0.0057
Schistosoma mansoni lipoxygenase 0.0021 0.0016 0.0037
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0075 0.0262
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0088 0.0088
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0209 0.2459
Schistosoma mansoni metabotropic glutamate receptor 0.0046 0.0099 0.0228
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.012 0.3441
Toxoplasma gondii microneme protein MIC17B 0.0017 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Brugia malayi nuclear receptor NHR-88 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0082 0.0189
Giardia lamblia DINP protein human, muc B family 0.0019 0.0009 0.0107
Onchocerca volvulus 0.0017 0.0001 0.0004
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0331 0.3953
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0082 0.0189
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0331 0.0585
Echinococcus granulosus dnaJ subfamily B 0.0439 0.1379 0.1379
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0134 0.0468
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0112 0.0391
Loa Loa (eye worm) hypothetical protein 0.0055 0.0126 0.0439
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0331 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.014 0.014
Schistosoma mansoni lamin 0.009 0.0239 0.0552
Chlamydia trachomatis endonuclease IV 0.008 0.0209 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0055 0.1445
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Brugia malayi Protein kinase domain containing protein 0.0026 0.0031 0.0108
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0148 0.0428 0.1499
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0118 0.0411
Onchocerca volvulus 0.0148 0.0428 0.1314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0082 0.0082
Onchocerca volvulus 0.0068 0.0169 0.0519
Echinococcus granulosus dna polymerase eta 0.0019 0.0009 0.0009
Brugia malayi Cation transporter family protein 0.0148 0.0428 0.1499
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0075 0.0262
Loa Loa (eye worm) ACC-1 protein 0.0148 0.0428 0.1499
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0047 0.0047
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0148 0.0428 0.1499
Toxoplasma gondii microneme protein MIC4 0.0017 0.0001 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0075 0.0173
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0051 0.0133
Brugia malayi Zona pellucida-like domain containing protein 0.0057 0.0134 0.0468
Brugia malayi hypothetical protein 0.0021 0.0015 0.0051
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0117 0.033 0.033
Echinococcus multilocularis geminin 0.0182 0.054 0.054
Echinococcus granulosus geminin 0.0182 0.054 0.054
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0055 0.1445
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0367 0.0367
Onchocerca volvulus 0.0031 0.0048 0.0146
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.004 0.0078 0.2156
Echinococcus multilocularis cpg binding protein 0.0033 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0287
Echinococcus granulosus cpg binding protein 0.0033 0.0053 0.0053
Onchocerca volvulus 0.0148 0.0428 0.1314
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0051 0.009
Onchocerca volvulus 0.0055 0.0128 0.0391
Brugia malayi hypothetical protein 0.0041 0.0082 0.0287
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0296 0.0683
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Brugia malayi nuclear hormone receptor 0.0018 0.0007 0.0026
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0051 0.2437
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0055 0.1445
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0009 0.0009
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0068 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0287
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0428 0.0428
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0082 0.0287
Brugia malayi phosphofructokinase 0.0118 0.0331 0.1158
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0051 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0075 0.0262
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0075 0.0173
Onchocerca volvulus 0.1016 0.326 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0061 0.1628
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0139 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0081 0.3858
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0007 0.0007
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0082 0.0082
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0082 0.0189
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0086 0.0229 0.0801
Onchocerca volvulus 0.0021 0.0016 0.005
Treponema pallidum hypothetical protein 0.0057 0.0134 0.0237
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0428 0.0428
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0009 0.0021
Echinococcus granulosus expressed protein 0.0805 0.2572 0.2572
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0139 0.6642
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0055 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0287
Onchocerca volvulus 0.0148 0.0428 0.1314
Plasmodium falciparum cysteine repeat modular protein 1 0.0026 0.0031 0.1471
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0075 0.0173
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0082 0.0287
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0027 0.0094
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0016 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.012 0.3267
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0139 0.1603
Schistosoma mansoni laminin gamma-3 chain 0.0054 0.0123 0.0285
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.012 0.5736
Entamoeba histolytica hypothetical protein 0.0057 0.0134 0.3879
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.012 0.145
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0001 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0134 0.3652
Echinococcus granulosus cell division control protein 45 0.01 0.0273 0.0273
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0148 0.0428 0.0989
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0051 0.0133
Toxoplasma gondii exonuclease III APE 0.0059 0.0139 0.1679
Loa Loa (eye worm) hypothetical protein 0.009 0.0239 0.0837
Brugia malayi hypothetical protein 0.0068 0.0169 0.0592
Brugia malayi nuclear receptor RXR 0.0021 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Brugia malayi nuclear receptor NHR-67 0.0018 0.0007 0.0026
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0428 0.0428
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0428 0.0989
Trichomonas vaginalis cdc25b, putative 0.0055 0.0126 0.0363
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0082 0.0287
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.012 0.5736
Echinococcus granulosus dna polymerase kappa 0.0019 0.0009 0.0009
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0082 0.0287
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0287
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0104 0.0362
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0078 0.0078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0025 0.0025
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0173 0.0173
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0075 0.0262
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0826 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1402 0.4519 0.4519
Loa Loa (eye worm) hypothetical protein 0.01 0.0273 0.0956
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0148 0.0428 0.0428
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0007 0.0007
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0179 0.0179
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0249 0.0759 0.1752
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0173 0.2002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0269 0.0826 0.0826
Echinococcus multilocularis lamin 0.009 0.0239 0.0239
Brugia malayi hypothetical protein 0.0068 0.0169 0.0592
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.012 0.3441
Brugia malayi hypothetical protein 0.01 0.0273 0.0956
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0148 0.0428 0.0428
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0007 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0075 0.0173
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0082 0.0189
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0007 0.0017
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0078 0.0842
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0075 0.0262
Schistosoma mansoni cell division control protein 45-related 0.01 0.0273 0.0631
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.1379 0.1379
Schistosoma mansoni coup transcription factor 0.0039 0.0075 0.0173
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.0002 0.0005
Loa Loa (eye worm) GABA receptor subunit 0.0079 0.0206 0.0722
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0061 0.1628
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0075 0.0262
Leishmania major cell division cycle 45 (CDC45), putative 0.0031 0.0047 0.0471
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0068 0.0169 0.0592
Entamoeba histolytica hypothetical protein 0.0041 0.0082 0.2268
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0026
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.014 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.0269 0.0826 0.1906
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0019 0.0008 0.0023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0075 0.0075
Onchocerca volvulus 0.0057 0.0134 0.0411
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0068 0.0169 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0367 0.0846
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.003 0.0362
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0331 0.3953
Onchocerca volvulus 0.0079 0.0206 0.0633
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0139 0.4029
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0082 0.0287
Onchocerca volvulus 0.0055 0.0126 0.0385
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0016 0.0443
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0078 0.0078
Schistosoma mansoni nAChR subunit 0.0068 0.0169 0.039
Echinococcus granulosus lamin 0.009 0.0239 0.0239
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0057 0.0134 0.0134
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0051 0.2437
Schistosoma mansoni lipoxygenase 0.0059 0.014 0.0324
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0126 0.3621
Echinococcus multilocularis dna polymerase eta 0.0019 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0075 0.0262
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.087 0.2786 0.2786
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0047 0.0047
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0139 0.4029
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0139 0.0403
Brugia malayi excitatory GABA receptor EXP-1A 0.0148 0.0428 0.1499
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0134 0.3879
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0082 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0075 0.0262
Plasmodium vivax SET domain protein, putative 0.0129 0.0367 1
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0017 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.0142
Brugia malayi hypothetical protein 0.0018 0.0007 0.0026
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0054 0.0123 0.0431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0078 0.0078
Schistosoma mansoni slit 0.0054 0.0123 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0075 0.0262
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0057 0.0134 0.0468
Brugia malayi Ets-domain containing protein 0.0071 0.0179 0.0626
Echinococcus multilocularis nAChR subunit 0.0148 0.0428 0.0428
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0182 0.054 0.1247
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Echinococcus multilocularis pikachurin 0.0054 0.0123 0.0123
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.0782 0.0782
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0001 0.0015
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0082 0.0082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0428 0.1499
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0007 0.0026
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.0123 0.0123
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.0428 0.0428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0075 0.0075
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0009 0.0017
Echinococcus granulosus nAChR subunit 0.0079 0.0206 0.0206
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0048 0.0167
Echinococcus multilocularis musashi 0.009 0.0239 0.0239
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0428 0.1499
Brugia malayi nuclear receptor NHR-88 0.0039 0.0075 0.0262
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0075 0.0075
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0367 0.0367
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0015 0.0051
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0082 0.0082
Echinococcus multilocularis nAChR subunit 0.0079 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Brugia malayi hypothetical protein 0.0018 0.0007 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0075 0.0262
Brugia malayi CXXC zinc finger family protein 0.0031 0.0048 0.0167
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0148 0.0428 0.1499
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0054 0.0123 0.0285
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0078 0.2137
Echinococcus multilocularis slit 2 protein 0.0054 0.0123 0.0123
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0148 0.0428 0.1499
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0001 0.0004
Schistosoma mansoni zinc finger protein 0.0018 0.0007 0.0017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0315 0.0975 0.0975
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0015 0.0015
Onchocerca volvulus 0.0021 0.0016 0.005
Trypanosoma brucei Cell division cycle 45 0.0031 0.0047 0.1196
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Brugia malayi Ets-domain containing protein 0.0071 0.0179 0.0626
Onchocerca volvulus 0.0018 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Onchocerca volvulus 0.0057 0.0134 0.0411
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0078 0.5354
Onchocerca volvulus 0.0018 0.0007 0.0023
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0055 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0229
Schistosoma mansoni hypothetical protein 0.0021 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0007 0.0026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0079 0.0206 0.0722
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.0123 0.0123
Schistosoma mansoni ap endonuclease 0.0059 0.0139 0.032
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0126 0.3621
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0075 0.0173
Onchocerca volvulus 0.0057 0.0134 0.0411
Loa Loa (eye worm) hypothetical protein 0.005 0.0112 0.0391
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0068 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0107 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0129 0.0367 0.1283
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0016 0.0049
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0126 0.0363
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0331 0.1158
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.012 0.0419
Onchocerca volvulus 0.0079 0.0206 0.0633
Trichomonas vaginalis cdc25c, putative 0.0055 0.0126 0.0363
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0269 0.0826 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0078 0.0216
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0428 0.0428
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.0239 0.0837
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0015 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0428 0.1499
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0075 0.0262
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0104 0.0362
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0176 0.0406
Loa Loa (eye worm) fli-1 protein 0.0216 0.0651 0.2277
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0269 0.0826 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0148 0.0428 0.1499
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0148 0.0428 0.1499
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0061 0.1628
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0051 0.0616
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.012 0.3441
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0068 0.0169 0.0592
Schistosoma mansoni ets-related 0.0216 0.0651 0.1502
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0272
Brugia malayi metabotropic glutamate receptor type 2 0.0046 0.0099 0.0346
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Echinococcus granulosus metabotropic glutamate receptor 2 0.008 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Schistosoma mansoni cpg binding protein 0.0031 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0148 0.0428 0.1499
Giardia lamblia Hypothetical protein 0.0031 0.0047 0.3043
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0007 0.0026
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0055 0.0126 0.0363
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0075 0.0075
Loa Loa (eye worm) TK/ROR protein kinase 0.0026 0.0031 0.0108
Entamoeba histolytica elongation factor-2 kinase, putative 0.0057 0.0134 0.3879
Brugia malayi hypothetical protein 0.0068 0.0169 0.0592
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Onchocerca volvulus 0.0057 0.0134 0.0411
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0075 0.0075
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0061 0.1628
Mycobacterium ulcerans hypothetical protein 0.0021 0.0016 0.0103
Schistosoma mansoni hypothetical protein 0.0057 0.0134 0.0309
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0075 0.0075
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0015 0.0034
Schistosoma mansoni DNA polymerase eta 0.0019 0.0009 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0051 0.0133
Schistosoma mansoni hypothetical protein 0.0276 0.0847 0.1955
Onchocerca volvulus 0.0017 0.0001 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0075 0.0262
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0082 0.0082
Schistosoma mansoni neurotransmitter gated ion channel 0.0068 0.0169 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0367 0.0846
Brugia malayi laminin-like protein K08C7.3 precursor 0.0054 0.0123 0.0431
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0331 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0075 0.0075
Brugia malayi Cation transporter family protein 0.0148 0.0428 0.1499
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0051 0.1388
Trichomonas vaginalis rotamase, putative 0.0036 0.0064 0.0174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0009 0.0004
Onchocerca volvulus 0.0057 0.0134 0.0411
Leishmania major hypothetical protein, conserved 0.0026 0.0031 0.0267
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0139 0.4029
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0126 0.0363
Onchocerca volvulus 0.0017 0.0001 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0296 0.0683
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0148 0.0428 0.1499
Schistosoma mansoni nuclear receptor 0.0018 0.0007 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0139 0.1603
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0078 0.0216
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0078 0.018
Onchocerca volvulus Putative nachr subunit 0.0148 0.0428 0.1314
Brugia malayi Cytochrome P450 family protein 0.0075 0.0193 0.0674
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0057 0.0134 0.0468
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0139 0.0139
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0331 0.0994
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0117 0.033 0.1155
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0051 0.3304
Schistosoma mansoni hypothetical protein 0.0052 0.0118 0.0271
Brugia malayi Pre-SET motif family protein 0.0129 0.0367 0.1283
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0047 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0367 0.0367
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0027 0.0094
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0001 0.0015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0269 0.0826 0.0826
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0055 0.0126 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0075 0.0262
Schistosoma mansoni hypothetical protein 0.004 0.0078 0.0181
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0209 0.0731
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0153 0.1853
Entamoeba histolytica cell division control protein 45 CDC45, putative 0.01 0.0273 0.8208
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0055 0.0126 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0082 0.0082
Brugia malayi hypothetical protein 0.0114 0.0321 0.1121
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0173 0.5079
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0047 0.2234
Mycobacterium ulcerans endonuclease IV 0.008 0.0209 0.2459
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0078 0.0272
Schistosoma mansoni intermediate filament proteins 0.009 0.0239 0.0552
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0007 0.0026
Echinococcus granulosus pikachurin 0.0054 0.0123 0.0123
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0428 0.1499
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0055 0.057
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0082 0.0229
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0276 0.0847 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0075 0.0262
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Schistosoma mansoni polycystin 1-related 0.0021 0.0016 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0193 0.0674
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0082 0.0082
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0047 0.0565
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0893 0.2858 1
Onchocerca volvulus 0.009 0.0239 0.0733
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0031
Echinococcus granulosus RUN 0.0021 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0041 0.0082 0.2268
Brugia malayi ecdysteroid receptor 0.0039 0.0075 0.0262
Echinococcus granulosus leukotriene A 4 hydrolase 0.0249 0.0759 0.0759
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0016 0.0057
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0089 0.0252
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0148 0.0428 0.0428
Brugia malayi 6-phosphofructokinase 0.0118 0.0331 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0064 0.0174
Plasmodium falciparum thrombospondin-related anonymous protein 0.0057 0.0134 0.6411
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0094
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0078 0.0078
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3082 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0068 0.0169 0.0592
Treponema pallidum 76K protein 0.0057 0.0134 0.0237
Onchocerca volvulus 0.0148 0.0428 0.1314
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Echinococcus granulosus tissue type plasminogen activator 0.0026 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0088 0.0234 0.0818
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0078 0.2137
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0089 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0315 0.0975 0.225
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0173 0.5079
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0079 0.0206 0.0722
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0007 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0078 0.0216
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0075 0.0075
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Brugia malayi Pre-SET motif family protein 0.0893 0.2858 1
Brugia malayi Cache domain containing protein 0.0621 0.1971 0.6897
Brugia malayi ecdysone receptor 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0054 0.0123 0.0431
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0007 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0139 0.0245
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Schistosoma mansoni aldehyde dehydrogenase 0.0269 0.0826 0.1906
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0148 0.0428 0.0428
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0057 0.0134 0.3652
Brugia malayi hypothetical protein 0.0262 0.0803 0.281
Echinococcus multilocularis lamin dm0 0.009 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0209 0.0731
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0331 0.0994
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0056
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.0428 0.0428
Echinococcus granulosus transcription factor Dp 1 0.004 0.0078 0.0078
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0051 0.2437
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0082 0.0189
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0331 1
Onchocerca volvulus 0.0017 0.0001 0.0004
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0001 0.0015
Onchocerca volvulus 0.0057 0.0134 0.0411
Brugia malayi hypothetical protein 0.0053 0.012 0.0419
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0349 0.0349
Schistosoma mansoni metabotropic glutamate receptor 0.008 0.0208 0.0479
Brugia malayi nuclear receptor RXR 0.0018 0.0007 0.0026
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0148 0.0428 0.0428
Brugia malayi hypothetical protein 0.0021 0.0015 0.0051
Entamoeba histolytica hypothetical protein 0.0079 0.0206 0.6131
Brugia malayi Doublecortin family protein 0.0021 0.0016 0.0057
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0051 0.1388
Loa Loa (eye worm) glutamate receptor 0.0095 0.0258 0.0903
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.0428 0.0428
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0009 0.0009
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0148 0.0428 0.0428
Brugia malayi follicle stimulating hormone receptor 0.0256 0.0782 0.2735
Brugia malayi EGF-like domain containing protein 0.0054 0.0123 0.0431
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0684 0.2178 0.762
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0163
Loa Loa (eye worm) hypothetical protein 0.0256 0.0782 0.2737
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0009 0.0031
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0621 0.1971 0.6897
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.0206 0.0722
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0089 0.0252
Brugia malayi hypothetical protein 0.0068 0.0169 0.0592
Schistosoma mansoni nAChR subunit 0.0068 0.0169 0.039
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0075 0.0262
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0047 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0139 0.0485
Brugia malayi Zona pellucida-like domain containing protein 0.0057 0.0134 0.0468
Onchocerca volvulus 0.0017 0.0001 0.0004
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0148 0.0428 0.0428
Brugia malayi hypothetical protein 0.004 0.0078 0.0274
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0148 0.0428 0.0428
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0089 0.0313
Onchocerca volvulus 0.0055 0.0126 0.0385
Echinococcus granulosus collagen alpha 1VII chain 0.0057 0.0134 0.0134
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0075 0.0075
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0249 0.0759 0.0759
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.175 0.5654 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0173 0.5079
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0128 0.0446
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0082 0.0082
Schistosoma mansoni acetylcholine receptor subunit beta 0.0068 0.0169 0.039
Schistosoma mansoni cpg binding protein 0.0033 0.0053 0.0123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0139 0.4029
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0331 1
Schistosoma mansoni lamin 0.009 0.0239 0.0552
Schistosoma mansoni serine-rich repeat protein 0.0724 0.2309 0.5328
Echinococcus multilocularis metabotropic glutamate receptor 2 0.008 0.0208 0.0208
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0009 0.0017
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0016 0.0016
Loa Loa (eye worm) CUTiclin family member 0.0057 0.0134 0.0468
Loa Loa (eye worm) glutamate receptor 0.0038 0.007 0.0243
Echinococcus multilocularis expressed protein 0.0036 0.0064 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0075 0.0075
Echinococcus granulosus lamin dm0 0.009 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0308
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0826 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0126 0.0439
Schistosoma mansoni neurotransmitter gated ion channel 0.0068 0.0169 0.039
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.0782 0.0782
Toxoplasma gondii microneme protein, putative 0.0017 0.0001 0.0015
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0016 0.0103
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0428 0.1499
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0051
Brugia malayi steroid hormone receptor 0.0039 0.0075 0.0262
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0009 0.0004
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0001 0.0015
Brugia malayi hypothetical protein 0.0041 0.0082 0.0287
Toxoplasma gondii subtilisin SUB12 0.0017 0.0001 0.0015
Brugia malayi Cation transporter family protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0057 0.0134 0.3652
Onchocerca volvulus 0.0039 0.0075 0.0229
Onchocerca volvulus 0.0017 0.0001 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0051 0.0133
Loa Loa (eye worm) CUTiclin-Like family member 0.0057 0.0134 0.0468
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0007 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0273 0.0817
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0078 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0082 0.0189
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0082 0.0189
Loa Loa (eye worm) intermediate filament protein 0.009 0.0239 0.0837
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0009 0.0009
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0007 0.0026
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0068 0.0169 0.0169
Onchocerca volvulus 0.0026 0.0031 0.0094
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0082 0.0287
Echinococcus multilocularis tissue type plasminogen activator 0.0026 0.0031 0.0031
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0082 0.0287
Brugia malayi PXA domain containing protein 0.0041 0.0082 0.0287
Onchocerca volvulus 0.0017 0.0001 0.0004
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0064 0.0224
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0082 0.0189
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0007 0.0007
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0082 0.0082
Schistosoma mansoni rab6-interacting 0.0021 0.0016 0.0037
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Echinococcus granulosus expressed protein 0.0036 0.0064 0.0064
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0139 0.1588
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0173 0.0398
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0173 0.5079
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0057 0.0134 0.3652
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0047 0.0163
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0001 0.0004
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0001 0.0004
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0078 0.2137
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0009 0.0017
Brugia malayi hypothetical protein 0.0034 0.0059 0.0205
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0078 0.0078
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0331 0.0331
Schistosoma mansoni thyroid hormone receptor 0.0315 0.0975 0.225
Loa Loa (eye worm) hypothetical protein 0.0054 0.0123 0.0431
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0148 0.0428 0.1499
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0173 0.0604
Echinococcus multilocularis tumor protein p63 0.0378 0.1179 0.1179
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Schistosoma mansoni acetylcholine receptor-related 0.0068 0.0169 0.039
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Brugia malayi hypothetical protein 0.0057 0.0134 0.0468
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0082 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0007 0.0007
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0078 0.0078
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0016 0.0016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0082 0.0189
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0126 0.3621
Onchocerca volvulus 0.0068 0.0169 0.0519
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0139 0.5
Onchocerca volvulus 0.0017 0.0001 0.0004
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0075 0.0262
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.0239 0.0837
Echinococcus granulosus voltage dependent calcium channel subunit 0.1402 0.4519 0.4519
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0007 0.0007
Loa Loa (eye worm) abnormal epIthelia family member 0.0054 0.0123 0.0431
Loa Loa (eye worm) RecQ helicase 0.0044 0.0089 0.0313
Trichomonas vaginalis set domain proteins, putative 0.1016 0.326 1
Entamoeba histolytica hypothetical protein 0.004 0.0078 0.2156
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0007 0.0017
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0148 0.0428 0.1499
Trypanosoma cruzi cell division cycle protein 45 (CDC45), putative 0.0031 0.0047 0.1196
Brugia malayi hypothetical protein 0.0021 0.0016 0.0057
Onchocerca volvulus 0.0055 0.0126 0.0385
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0075 0.0173
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0075 0.0075
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0061 0.0145 0.0508
Loa Loa (eye worm) LGC-31 protein 0.0148 0.0428 0.1499
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0017 0.0001 0.0004
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0061 0.0642
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0126 0.0363
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0064 0.0224
Onchocerca volvulus 0.0055 0.0126 0.0385
Toxoplasma gondii aldehyde dehydrogenase 0.0269 0.0826 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0047 0.0163
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0287
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0051 0.2437
Onchocerca volvulus 0.0052 0.0118 0.036
Entamoeba histolytica hypothetical protein 0.004 0.0078 0.2156
Trichomonas vaginalis cdc25b, putative 0.0055 0.0126 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0075 0.0262
Brugia malayi hypothetical protein 0.0021 0.0016 0.0057
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0027 0.0094
Brugia malayi Fli-1 protein 0.0216 0.0651 0.2277
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0016 0.0777
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0016 0.0016
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0057 0.0134 0.6411
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.0206 0.0476
Entamoeba histolytica hypothetical protein 0.004 0.0078 0.2156
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0826 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0095 0.0258 0.0903
Onchocerca volvulus 0.0129 0.0367 0.1125
Brugia malayi von Willebrand Factor 0.0057 0.0134 0.0468
Leishmania major hypothetical protein, conserved 0.0053 0.012 0.1357
Brugia malayi Rhodanese-like domain containing protein 0.0055 0.0126 0.0439
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0428 0.0989
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0428 0.0428
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0047 0.0163
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0075 0.0173
Brugia malayi intermediate filament protein 0.009 0.0239 0.0837
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Brugia malayi Sulfatase family protein 0.0019 0.0008 0.0026
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0088 0.0088
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0296 0.0683
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0139 0.0403
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0051 0.0133
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0678 0.2158 0.4981
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0229
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0015 0.0051
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0082 0.0287
Echinococcus multilocularis cell division control protein 45 0.01 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Entamoeba histolytica hypothetical protein 0.0041 0.0082 0.2268
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0047 0.2981
Mycobacterium ulcerans epimerase 0.0021 0.0016 0.0103
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0075 0.0262
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0075 0.0173
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0148 0.0428 0.0428
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0075 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0082 0.0189
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0229
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0057 0.0134 0.1621
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0262
Loa Loa (eye worm) hypothetical protein 0.0068 0.0169 0.0592
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0173 0.0604
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.0428 0.0428
Schistosoma mansoni nuclear receptor 0.0018 0.0007 0.0017
Schistosoma mansoni DNA helicase recq1 0.003 0.0047 0.0108
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0276 0.0847 0.0847
Toxoplasma gondii microneme protein MIC17C 0.0017 0.0001 0.0015
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0209 0.5696
Toxoplasma gondii endonuclease IV APN 0.008 0.0209 0.2528
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0075 0.0075
Toxoplasma gondii PAN/Apple domain-containing protein 0.0017 0.0001 0.0015
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0082 0.0287
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0331 0.0994
Brugia malayi Kringle domain containing protein 0.0026 0.0031 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0367 0.0846
Loa Loa (eye worm) acetylcholine receptor protein 0.0068 0.0169 0.0592
Brugia malayi 6-phosphofructokinase 0.0118 0.0331 0.1158
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0025 0.0025
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0148 0.0428 0.0989
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0331 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0047 0.0565
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0078 0.2137
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0428 0.1499
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0075 0.0262
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0082 0.0287
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0148 0.0428 0.1499
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0068 0.0169 0.0592
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0051 0.0133
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0051
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0016 0.0103
Onchocerca volvulus 0.0068 0.0169 0.0519
Trypanosoma cruzi cell division cycle protein 45 (CDC45), putative 0.0031 0.0047 0.1196
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0075 0.0075
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0148 0.0428 0.0428
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0068 0.0169 0.0592
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Echinococcus granulosus tumor protein p63 0.0378 0.1179 0.1179
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0139 0.0485
Echinococcus multilocularis expressed protein 0.0805 0.2572 0.2572
Schistosoma mansoni gabp alpha 0.0071 0.0179 0.0413
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0051
Toxoplasma gondii hypothetical protein 0.0017 0.0001 0.0015
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.0428 0.0428
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0722
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0068 0.0169 0.0592
Schistosoma mansoni cpg binding protein 0.0033 0.0053 0.0123
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0148 0.0428 0.0428
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0148 0.0428 0.0989
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0128 0.0294
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0331 0.0764
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0032 0.0868
Schistosoma mansoni nAChR subunit 0.0148 0.0428 0.0989
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.0782 0.2735
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0026 0.0031 0.0838
Echinococcus granulosus nAChR subunit 0.0148 0.0428 0.0428
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Loa Loa (eye worm) hypothetical protein 0.0107 0.0296 0.1035
Brugia malayi hypothetical protein 0.0068 0.0169 0.0592
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0428 0.1499
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0182 0.054 0.1247
Onchocerca volvulus 0.0148 0.0428 0.1314
Toxoplasma gondii hypothetical protein 0.0017 0.0001 0.0015
Brugia malayi laminin alpha chain 0.0054 0.0123 0.0431
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0331 0.0764
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0082 0.0082
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0078 0.0181
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0134 0.3879
Trichomonas vaginalis rotamase, putative 0.0035 0.0061 0.0165
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0082 0.0082
Toxoplasma gondii microneme protein MIC17A 0.0017 0.0001 0.0015
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0082 0.0082
Plasmodium vivax thrombospondin-related anonymous protein 0.0057 0.0134 0.3652
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0331 0.1158
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0007 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0367 0.4439
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0068 0.0169 0.0592
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0287
Loa Loa (eye worm) hypothetical protein 0.0148 0.0428 0.1499
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0055 0.0126 0.0363
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1345 0.4333 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.0206 0.0722
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0007 0.0007
Schistosoma mansoni survival motor neuron protein 0.0052 0.0118 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0229
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0051 0.1302
Loa Loa (eye worm) hypothetical protein 0.0057 0.0134 0.0468
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0209 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0075 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0031 0.0676
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0026
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0134 0.0468
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0075 0.0173
Brugia malayi Rhodanese-like domain containing protein 0.0055 0.0126 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Brugia malayi PAN domain containing protein 0.0017 0.0001 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0075 0.0075
Onchocerca volvulus 0.0148 0.0428 0.1314
Schistosoma mansoni hypothetical protein 0.0724 0.2309 0.5328
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0051 0.0616
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0051
Brugia malayi tailless protein 0.0018 0.0007 0.0026
Brugia malayi hypothetical protein 0.0019 0.0008 0.0026
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0082 0.0189
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0082 0.0082
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0039 0.0089
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0001 0.0015

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 73 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 12620069
Ki (binding) = 73 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 12620069
Ki (binding) = 290 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2 ChEMBL. 12620069
Ki (binding) = 290 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2 ChEMBL. 12620069
Ki (binding) = 354 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta2 ChEMBL. 12620069
Ki (binding) = 354 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta2 ChEMBL. 12620069
Ki (binding) = 637 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4 ChEMBL. 12620069
Ki (binding) = 637 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4 ChEMBL. 12620069
Ki (binding) = 717 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 ChEMBL. 12620069
Ki (binding) = 717 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 ChEMBL. 12620069
Ki (binding) = 2280 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4 ChEMBL. 12620069
Ki (binding) = 2280 nM Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4 ChEMBL. 12620069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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