TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.404 | Formula: C22H19N3O4
H donors: 3 H acceptors: 2 LogP: 3.01 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)/C=c/1\[nH]c(=O)/c(=C/c2c[nH]c3c2cccc3)/[nH]c1=O
InChi: 1S/C22H19N3O4/c1-28-19-8-7-13(10-20(19)29-2)9-17-21(26)25-18(22(27)24-17)11-14-12-23-16-6-4-3-5-15(14)16/h3-12,23H,1-2H3,(H,24,27)(H,25,26)/b17-9-,18-11-
InChiKey: QRNGDVVTRCNUDO-YYIZJUOFSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0653	0.2264
Schistosoma mansoni	carbonyl reductase	0.0045	0.0365	0.0383
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus granulosus	peregrin	0.003	0.0214	0.0224
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0045	0.0365	0.0383
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0045	0.0365	0.0383
Echinococcus granulosus	Chromo domain	0.0012	0.0022	0.0023
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0045	0.0365	0.1257
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0069	0.0072
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0045	0.0365	0.0383
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0438	0.0459
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Schistosoma mansoni	cpg binding protein	0.0027	0.0179	0.0188
Mycobacterium ulcerans	glutaminase	0.0285	0.2859	1
Brugia malayi	PHD-finger family protein	0.0011	0.0016	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Onchocerca volvulus	Alhambra homolog	0.003	0.0214	0.5592
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus multilocularis	retinol dehydrogenase 11	0.0045	0.0365	0.0383
Echinococcus multilocularis	oxidoreductase	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0353	0.1214
Brugia malayi	Protein cec-1.	0.0012	0.0022	0.0023
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0077	0.0695	0.5683
Toxoplasma gondii	NADPH-glutathione reductase	0.001	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Leishmania major	short chain dehydrogenase-like protein	0.0045	0.0365	0.0365
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0045	0.0365	0.1382
Plasmodium falciparum	phd finger protein, putative	0.003	0.0214	0.5853
Toxoplasma gondii	oxidoreductase, putative	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0045	0.0365	0.1257
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0067	0.0071
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0069	0.0072
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Leishmania major	quinonoid dihydropteridine reductase	0.0971	1	1
Echinococcus multilocularis	peregrin	0.003	0.0214	0.0224
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.0365	0.2958
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0069	0.0072
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0022	0.0023
Plasmodium vivax	steroid dehydrogenase, putative	0.0045	0.0365	1
Entamoeba histolytica	hypothetical protein	0.0045	0.0365	0.1333
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0045	0.0365	1
Treponema pallidum	fructose-bisphosphate aldolase	0.026	0.2601	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0127	0.1218	1
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0365	0.0365
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Brugia malayi	dihydropteridine reductase-like	0.0926	0.9533	1
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0353	0.1214
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0045	0.0365	0.0383
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Schistosoma mansoni	retinal dehydrogenase	0.0045	0.0365	0.0383
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0045	0.0365	1
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0653	0.0685
Brugia malayi	jmjC domain containing protein	0.0099	0.0932	0.0978
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short-chain dehydrogenase	0.0045	0.0365	0.1257
Brugia malayi	AF-10 protein	0.001	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Schistosoma mansoni	chromobox protein	0.0073	0.0653	0.0685
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0012	0.0022	0.0591
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Onchocerca volvulus		0.0045	0.0365	1
Entamoeba histolytica	hypothetical protein, conserved	0.0045	0.0365	0.1333
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.001	0.0007	0.0007
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0011	0.0015	0.0016
Giardia lamblia	Hypothetical protein	0.0045	0.0365	0.1382
Schistosoma mansoni	hypothetical protein	0.0016	0.0069	0.0072
Leishmania major	short chain dehydrogenase/reductase, putative	0.0045	0.0365	0.0365
Brugia malayi	Thioredoxin reductase	0.003	0.0213	0.0223
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus granulosus	carbonyl reductase 1	0.0045	0.0365	0.0383
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0438	0.0459
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0214	0.0224
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0045	0.0365	0.2958
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.001	0.0007	0.0193
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0045	0.0365	0.0365
Brugia malayi	jmjC domain containing protein	0.0038	0.0295	0.031
Onchocerca volvulus		0.0045	0.0365	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0031	0.0217	0.0227
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0295	0.031
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0045	0.0365	0.2958
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0653	0.0685
Echinococcus multilocularis	carbonyl reductase 1	0.0045	0.0365	0.0383
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0045	0.0365	0.0365
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0045	0.0365	0.2958
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0045	0.0365	0.1257
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0045	0.0365	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Plasmodium falciparum	glutathione reductase	0.003	0.0213	0.5816
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0045	0.0365	0.0365
Mycobacterium ulcerans	short-chain dehydrogenase	0.0045	0.0365	0.1257
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0017	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Echinococcus granulosus	steroid dehydrogenase	0.0045	0.0365	0.0383
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0045	0.0365	0.0383
Onchocerca volvulus		0.0045	0.0365	1
Onchocerca volvulus		0.0045	0.0365	1
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0022	0.0591
Brugia malayi	hypothetical protein	0.0012	0.0022	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0321	0.1101
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0045	0.0365	0.0365
Trichomonas vaginalis	Heterochromatin protein, putative	0.0012	0.0022	0.0051
Echinococcus granulosus	thioredoxin glutathione reductase	0.0031	0.0217	0.0227
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0045	0.0365	1
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0045	0.0365	0.2958
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0069	0.0072
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.001	0.0007	0.0007
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	dehydrogenase	0.0045	0.0365	0.1257
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Loa Loa (eye worm)	transcription factor SMAD2	0.0106	0.1002	0.1051
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0022	0.0023
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Echinococcus granulosus	carbonyl reductase 1	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0439	0.0461
Echinococcus multilocularis	carbonyl reductase 1	0.0045	0.0365	0.0383
Schistosoma mansoni	cpg binding protein	0.0027	0.0179	0.0188
Onchocerca volvulus		0.0045	0.0365	1
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0012	0.0022	0.0591
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0045	0.0365	0.0365
Mycobacterium ulcerans	dehydrogenase/reductase	0.0045	0.0365	0.1257
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0022	0.0023
Brugia malayi	chromobox protein homolog 3	0.0041	0.0321	0.0337
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0069	0.0072
Schistosoma mansoni	glutaminase	0.0285	0.2859	0.2999
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0045	0.0365	0.1333
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0045	0.0365	0.0365
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.001	0.0007	0.0193
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0045	0.0365	0.2958
Echinococcus granulosus	carbonyl reductase 1	0.0045	0.0365	0.0383
Mycobacterium ulcerans	ketoacyl reductase	0.0045	0.0365	0.1257
Schistosoma mansoni	cpg binding protein	0.0026	0.0164	0.0172
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0438	0.0459
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0022	0.0051
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.001	0.0007	0.0007
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0054	0.0164
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0321	0.8711
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	Probable dehydrogenase	0.0069	0.0615	0.5022
Schistosoma mansoni	hypothetical protein	0.0016	0.0069	0.0072
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0069	0.0072
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.055	0.0577
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0164	0.0172
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0213	0.0213
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.001	0.0007	0.5
Toxoplasma gondii	6,7-dihydropteridine reductase	0.0926	0.9533	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.001	0.0007	0.0007
Echinococcus granulosus	carbonyl reductase 1	0.0045	0.0365	0.0383
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Plasmodium falciparum	steroid dehydrogenase, putative	0.0045	0.0365	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0045	0.0365	0.0383
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0045	0.0365	1
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.0365	0.2958
Leishmania major	short chain dehydrogenase, putative	0.0045	0.0365	0.0365
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0022	0.0051
Schistosoma mansoni	hypothetical protein	0.0035	0.0267	0.028
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0198	0.0668
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0045	0.0365	0.1333
Leishmania major	hypothetical protein, conserved	0.0045	0.0365	0.0365
Trypanosoma brucei	oxidoreductase-like protein	0.0045	0.0365	1
Echinococcus granulosus	chromobox protein 1	0.0073	0.0653	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0001	0.0035
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0022	0.0023
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0082	0.0262
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.0365	0.2958
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Echinococcus multilocularis	cpg binding protein	0.0027	0.0179	0.0188
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0045	0.0365	0.0383
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0011	0.0015	0.0016
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0082	0.0086
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Leishmania major	hypothetical protein, conserved	0.0045	0.0365	0.0365
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0082	0.0262
Leishmania major	hypothetical protein, conserved	0.0045	0.0365	0.0365
Echinococcus multilocularis	Chromo domain	0.0012	0.0022	0.0023
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0932	0.0978
Leishmania major	quinonoid dihydropteridine reductase	0.0971	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0164	0.0172
Entamoeba histolytica	short chain dehydrogenase family protein	0.0045	0.0365	0.1333
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Echinococcus granulosus	retinol dehydrogenase 11	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0267	0.028
Schistosoma mansoni	chromobox protein	0.0073	0.0653	0.0685
Brugia malayi	Bromodomain containing protein	0.003	0.0214	0.0224
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.003	0.0214	0.0224
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0022	0.0051
Leishmania major	quinonoid dihydropteridine reductase	0.0971	1	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0045	0.0365	0.0365
Brugia malayi	SET domain containing protein	0.0012	0.0027	0.0029
Leishmania major	quinonoid dihydropteridine reductase	0.0971	1	1
Echinococcus granulosus	retinol dehydrogenase 11	0.0045	0.0365	0.0383
Plasmodium vivax	glutathione reductase, putative	0.003	0.0213	0.5816
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0214	0.0224
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0045	0.0365	0.1257
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Leishmania major	dehydrogenase-like protein	0.0045	0.0365	0.0365
Loa Loa (eye worm)	glutathione reductase	0.003	0.0213	0.0223
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0082	0.0262
Mycobacterium tuberculosis	Probable oxidoreductase	0.0077	0.0695	0.5683
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0045	0.0365	0.1333
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0022	0.0023
Loa Loa (eye worm)	dihydropteridine reductase-PC	0.0926	0.9533	1
Schistosoma mansoni	dihydropteridine reductase	0.0926	0.9533	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0106	0.1002	0.1051
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0022	0.0051
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.0365	0.2958
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0045	0.0365	0.0383
Leishmania major	trypanothione reductase	0.003	0.0213	0.0213
Brugia malayi	glutathione reductase	0.003	0.0213	0.0223
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0127	0.1218	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0353	0.9645
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0338	0.0354
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.001	0.0007	0.0007
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.0365	0.2958
Leishmania major	oxidoreductase-like protein	0.0045	0.0365	0.0365
Echinococcus granulosus	NADP binding domain	0.0926	0.9533	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Leishmania major	short chain dehydrogenase/reductase, putative	0.0045	0.0365	0.0365
Schistosoma mansoni	chromobox protein	0.0012	0.0022	0.0023
Echinococcus multilocularis	steroid dehydrogenase	0.0045	0.0365	0.0383
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0045	0.0365	0.2958
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0045	0.0365	0.2958
Toxoplasma gondii	thioredoxin reductase	0.003	0.0213	0.0223
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0045	0.0365	0.0365
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0214	0.0224
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Trichomonas vaginalis	hypothetical protein	0.0012	0.0022	0.0051
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0045	0.0365	0.0365
Brugia malayi	dehydrogenases, short chain protein 2	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0022	0.0051
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0022	0.0023
Onchocerca volvulus		0.0045	0.0365	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0022	0.0023
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0214	0.0224
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0045	0.0365	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0069	0.0072
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.001	0.0007	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Leishmania major	quinonoid dihydropteridine reductase	0.0971	1	1
Schistosoma mansoni	hypothetical protein	0.003	0.0214	0.0224
Loa Loa (eye worm)	glutaminase 2	0.0285	0.2859	0.2999
Onchocerca volvulus		0.0032	0.023	0.6053
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0045	0.0365	0.2958
Echinococcus multilocularis	retinol dehydrogenase 11	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0017
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0045	0.0365	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0045	0.0365	1
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Giardia lamblia	PHD finger protein 15	0.003	0.0214	0.0797
Mycobacterium tuberculosis	Possible oxidoreductase	0.0045	0.0365	0.2958
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Brugia malayi	glutaminase DH11.1	0.0285	0.2859	0.2999
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0045	0.0365	0.0383
Onchocerca volvulus		0.0045	0.0365	1
Brugia malayi	dehydrogenases, short chain protein 9	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0045	0.0365	0.2958
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0069	0.0615	0.5022
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0045	0.0365	0.0383
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0022	0.0023
Echinococcus multilocularis	retinol dehydrogenase 13	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0082	0.0262
Onchocerca volvulus		0.0045	0.0365	1
Echinococcus granulosus	hypothetical protein	0.0045	0.0365	0.0383
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0365	0.0365
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0127	0.1218	0.4247
Loa Loa (eye worm)	hypothetical protein	0.0032	0.023	0.0241
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0295	0.031
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0045	0.0365	1
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0045	0.0365	0.0383
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Echinococcus multilocularis	carbonyl reductase 1	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Plasmodium vivax	thioredoxin reductase, putative	0.003	0.0213	0.5816
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0022	0.0023
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0045	0.0365	0.1257
Echinococcus multilocularis	transient receptor potential cation channel	0.0045	0.0365	0.0383
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0295	0.031
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.0365	0.2958
Echinococcus granulosus	cpg binding protein	0.0027	0.0179	0.0188
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0077	0.0695	0.5683
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0653	0.2264
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0082	0.0262
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0653	0.0685
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0069	0.0615	0.5022
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0365	0.0365
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0012	0.0022	0.0023
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0045	0.0365	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0045	0.0365	1
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0214	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0321	0.1101
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0045	0.0365	0.0383
Onchocerca volvulus		0.0045	0.0365	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Onchocerca volvulus		0.0045	0.0365	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0082	0.0262
Echinococcus granulosus	chromobox protein 1	0.0073	0.0653	0.0685
Entamoeba histolytica	hypothetical protein, conserved	0.0045	0.0365	0.1333
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus granulosus	oxidoreductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0022	0.0051
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0007	0.0007
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.0037	0.0039
Brugia malayi	Heterochromatin protein 1	0.0073	0.0653	0.0685
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Loa Loa (eye worm)	thioredoxin reductase	0.003	0.0213	0.0223
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0045	0.0365	0.0365
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.001	0.0007	0.0007
Onchocerca volvulus	Sepiapterin reductase homolog	0.0045	0.0365	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0365	0.0365
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.001	0.0007	0.0007
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.001	0.0007	0.0193
Leishmania major	short chain dehydrogenase, putative	0.0045	0.0365	0.0365
Leishmania major	hypothetical protein, conserved	0.0045	0.0365	0.0365
Brugia malayi	PHD-finger family protein	0.003	0.0214	0.0224
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0022	0.0023
Mycobacterium tuberculosis	Probable dehydrogenase	0.0045	0.0365	0.2958
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.001	0.0007	0.0193
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0048	0.0401	0.0421
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0045	0.0365	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.026	0.2601	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Plasmodium falciparum	glutathione reductase	0.001	0.0007	0.0193
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0045	0.0365	0.0383
Trypanosoma cruzi	trypanothione reductase, putative	0.001	0.0007	0.0007
Echinococcus granulosus	GPCR family 2	0.0016	0.0069	0.0072
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Plasmodium falciparum	thioredoxin reductase	0.001	0.0007	0.0193
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.001	0.0007	0.0007
Mycobacterium tuberculosis	Possible oxidoreductase	0.0045	0.0365	0.2958
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0045	0.0365	0.0383
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0045	0.0365	0.2958
Mycobacterium ulcerans	short-chain dehydrogenase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0321	0.0337
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0049	0.0149
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0001
Echinococcus granulosus	WW domain containing oxidoreductase	0.0045	0.0365	0.0383
Brugia malayi	oxidoreductase	0.0045	0.0365	0.0383
Brugia malayi	hypothetical protein	0.0045	0.0365	0.0383
Echinococcus multilocularis	NAD(P) binding domain	0.0926	0.9533	1
Plasmodium vivax	heterochromatin protein 1, putative	0.0012	0.0022	0.0591
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0022	0.0023
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0069	0.0615	0.5022
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0045	0.0365	0.0383
Schistosoma mansoni	hypothetical protein	0.0012	0.0022	0.0023
Trypanosoma brucei	trypanothione reductase	0.003	0.0213	0.5816
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.026	0.2601	1
Onchocerca volvulus		0.0045	0.0365	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.001	0.0007	0.0193
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0082	0.0262
Giardia lamblia	Fructose-bisphosphate aldolase	0.026	0.2601	1
Onchocerca volvulus		0.0045	0.0365	1
Schistosoma mansoni	carbonyl reductase	0.0045	0.0365	0.0383
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0214	0.5853
Schistosoma mansoni	hypothetical protein	0.0016	0.0069	0.0072
Mycobacterium ulcerans	oxidoreductase	0.0045	0.0365	0.1257
Echinococcus granulosus	chromobox protein 2	0.0012	0.0022	0.0023
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0045	0.0365	0.2958
Brugia malayi	hypothetical protein	0.0045	0.0365	0.0383
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0045	0.0365	0.0365
Plasmodium falciparum	thioredoxin reductase	0.003	0.0213	0.5816
Giardia lamblia	Short-chain dehydrogenase, putative	0.0045	0.0365	0.1382
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0045	0.0365	0.1257
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0082	0.0262
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.0037	0.0039
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0045	0.0365	0.1257
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0001	0.0035
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0045	0.0365	0.0365
Brugia malayi	Dehydrogenases, short chain protein 30	0.0045	0.0365	0.0383
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Leishmania major	pteridine reductase 1	0.0045	0.0365	0.0365
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.001	0.0007	0.0007
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	dehydrogenase	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.003	0.0213	0.1696
Schistosoma mansoni	hypothetical protein	0.0016	0.0069	0.0072
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0069	0.0615	0.5022
Schistosoma mansoni	chromobox protein	0.0012	0.0022	0.0023
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0045	0.0365	0.1257
Giardia lamblia	Reductase, putative	0.0045	0.0365	0.1382
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0054	0.0461	0.0484
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0077	0.0695	0.3869
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Mycobacterium ulcerans	ketoacyl reductase	0.0045	0.0365	0.1257
Trichomonas vaginalis	glutaminase, putative	0.0285	0.2859	1
Brugia malayi	MH2 domain containing protein	0.0106	0.1002	0.1051
Echinococcus multilocularis	steroid dehydrogenase	0.0045	0.0365	0.0383
Schistosoma mansoni	carbonyl reductase	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0069	0.0615	0.2931
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0022	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0438	0.0459
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0054	0.0164
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Mycobacterium ulcerans	short-chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0971	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0198	0.0668
Loa Loa (eye worm)	helicase	0.0012	0.0022	0.0023
Echinococcus granulosus	hypothetical protein	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0012	0.0022	0.0023
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0045	0.0365	0.1333
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0045	0.0365	0.2958
Toxoplasma gondii	carbonyl reductase 1, putative	0.0045	0.0365	0.0383
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0022	0.0023
Plasmodium falciparum	heterochromatin protein 1	0.0012	0.0022	0.0591
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.001	0.0007	0.0193
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0338	0.0354
Onchocerca volvulus		0.0026	0.0164	0.4132
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Loa Loa (eye worm)	dehydrogenase	0.0045	0.0365	0.0383
Onchocerca volvulus		0.0045	0.0365	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0045	0.0365	0.0365
Brugia malayi	CHD4 protein	0.0013	0.0037	0.0039
Schistosoma mansoni	steroid dehydrogenase	0.0045	0.0365	0.0383
Mycobacterium tuberculosis	Probable reductase	0.0069	0.0615	0.5022
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0045	0.0365	0.1257
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0045	0.0365	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0295	0.031
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Onchocerca volvulus		0.0012	0.0027	0.0169
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0012	0.0027	0.0029
Toxoplasma gondii	PHD-finger domain-containing protein	0.001	0.0001	0.0001
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Leishmania major	3-keto-dihydrosphingosine reductase	0.0045	0.0365	0.0365
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0045	0.0365	0.0383
Brugia malayi	Retinol dehydrogenase 12	0.0045	0.0365	0.0383
Leishmania major	quinonoid dihydropteridine reductase	0.0971	1	1
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.001	0.0001	0.0001
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.028	0.0294
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0045	0.0365	0.0365
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0022	0.0051
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0012	0.0022	0.0023
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0045	0.0365	0.0365
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0045	0.0365	0.0383
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.072	0.0755
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0045	0.0365	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.0045	0.0365	0.1333
Brugia malayi	Dehydrogenases, short chain protein 2	0.0045	0.0365	0.0383
Mycobacterium ulcerans	short chain dehydrogenase	0.0045	0.0365	0.1257
Mycobacterium ulcerans	oxidoreductase	0.0045	0.0365	0.1257
Echinococcus multilocularis	carbonyl reductase 1	0.0045	0.0365	0.0383
Toxoplasma gondii	oxidoreductase, putative	0.0045	0.0365	0.0383
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.026	0.2601	0.9095
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0214	0.0224
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0069	0.0072
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0932	0.0978
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0011	0.0017	0.0478
Loa Loa (eye worm)	oxidoreductase	0.0045	0.0365	0.0383
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0069	0.0072
Loa Loa (eye worm)	glutaminase	0.0285	0.2859	0.2999
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0045	0.0365	1
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0365	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0045	0.0365	0.0365
Leishmania major	hypothetical protein, conserved	0.0045	0.0365	0.0365
Echinococcus multilocularis	conserved hypothetical protein	0.0045	0.0365	0.0383
Schistosoma mansoni	short chain dehydrogenase	0.0045	0.0365	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0365	0.0383
Mycobacterium ulcerans	ketoacyl reductase	0.0045	0.0365	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0023
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0045	0.0365	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0045	0.0365	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0365	0.2958
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0365	0.1257
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0045	0.0365	0.0383
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0037	0.0039
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0045	0.0365	0.1257
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0045	0.0365	0.0365
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.001	0.0007	0.0193
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0045	0.0365	0.0383
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0267	0.028

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	> 100 ug ml-1	Compound was tested for brine shrimp (Artemia salina) toxicity measured as the lowest value at which severe inhibition of nauplii movement was observed	ChEMBL.	10673087

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 304393