Detailed information for compound 325083

Basic information

Technical information
  • TDR Targets ID: 325083
  • Name: [1-[(4-fluorophenyl)methyl]cyclobutyl]methyl N-[(3S)-7-(morpholine-4-carbonylamino)-1,2-di oxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl] carbamate
  • MW: 610.716 | Formula: C33H43FN4O6
  • H donors: 3 H acceptors: 4 LogP: 4.33 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)C(=O)N[C@@H](c1ccccc1)C)CCCCNC(=O)N1CCOCC1)OCC1(CCC1)Cc1ccc(cc1)F
  • InChi: 1S/C33H43FN4O6/c1-24(26-8-3-2-4-9-26)36-30(40)29(39)28(10-5-6-17-35-31(41)38-18-20-43-21-19-38)37-32(42)44-23-33(15-7-16-33)22-25-11-13-27(34)14-12-25/h2-4,8-9,11-14,24,28H,5-7,10,15-23H2,1H3,(H,35,41)(H,36,40)(H,37,42)/t24-,28+/m1/s1
  • InChiKey: BSRQMYCWEZBYDT-YWEHKCAJSA-N  


Substructure search Similarity search

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Synonyms

  • [1-[(4-fluorophenyl)methyl]cyclobutyl]methyl N-[(1S)-5-(morpholine-4-carbonylamino)-1-[2-oxo-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamate
  • N-[(1S)-1-[1,2-dioxo-2-[[(1R)-1-phenylethyl]amino]ethyl]-5-[[morpholino(oxo)methyl]amino]pentyl]carbamic acid [1-[(4-fluorophenyl)methyl]cyclobutyl]methyl ester
  • [1-[(4-fluorophenyl)methyl]cyclobutyl]methyl N-[(3S)-7-(morpholin-4-ylcarbonylamino)-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]heptan-3-yl]carbamate
  • N-[(1S)-1-[2-keto-2-[[(1R)-1-phenylethyl]amino]acetyl]-5-(morpholine-4-carbonylamino)pentyl]carbamic acid [1-(4-fluorobenzyl)cyclobutyl]methyl ester
  • N-[(1S)-1-[1,2-dioxo-2-[[(1R)-1-phenylethyl]amino]ethyl]-5-[(morpholino-oxomethyl)amino]pentyl]carbamic acid [1-[(4-fluorophenyl)methyl]cyclobutyl]methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin H Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin H 335 aa 340 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.008 0.0073
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0067 0.0067
Brugia malayi Cytochrome P450 family protein 0.0023 0.0034 0.0012
Leishmania major alpha glucosidase II subunit, putative 0.0028 0.0123 0.0244
Echinococcus granulosus metabotropic glutamate receptor 5 0.0325 0.5142 0.5129
Plasmodium falciparum cysteine proteinase falcipain 1 0.0061 0.067 0.2008
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0272 0.0698
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0067 0.0067
Schistosoma mansoni alpha glucosidase 0.0028 0.0123 0.0123
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0025 0.0025
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.2872
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0884 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0884 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0884 0.0861
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.008 0.0037
Onchocerca volvulus 0.01 0.1332 0.3464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0066 0.0042
Loa Loa (eye worm) hypothetical protein 0.0073 0.0884 0.0861
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.1332 0.1311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0082 0.0082
Toxoplasma gondii cathepsin B 0.0075 0.0908 0.2792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0102
Schistosoma mansoni metabotropic glutamate receptor 0.0129 0.1822 0.1822
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0884 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.008 0.0073
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0107 0.1462 0.1894
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0204 0.3097 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.008 0.0073
Giardia lamblia Cathepsin B precursor 0.0025 0.0067 0.0023
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0107 0.1462 0.4617
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0025 0.0067 0.0102
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0325 0.5142 0.5129
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0107 0.1462 0.1462
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0056
Brugia malayi Metabotropic glutamate receptor precursor. 0.0264 0.411 0.5385
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0067 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0249 0.0433
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0073 0.0884 0.0861
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0464
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0546 0.0523
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0123 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.073 0.1721
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.7551 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0075 0.0908 0.2396
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.067 0.067
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0204 0.3097 0.3079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0884 0.2062
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1332 0.2611
Echinococcus granulosus cathepsin l1 0.0064 0.073 0.0707
Onchocerca volvulus 0.01 0.1332 0.3464
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0043 0.0371 0.0457
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0204 0.3097 0.3079
Giardia lamblia Cysteine protease 0.0025 0.0067 0.0023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.067 0.1548
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0066 0.0042
Echinococcus granulosus cathepsin L cysteine proteinase 0.01 0.1332 0.1311
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.008 0.0073
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0052 0.052 0.0497
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.067 0.085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.004
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0239 0.369 0.4832
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Entamoeba histolytica hypothetical protein 0.0025 0.0067 0.0018
Loa Loa (eye worm) hypothetical protein 0.01 0.1332 0.1311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.198 0.198
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Entamoeba histolytica cysteine protease, putative 0.0025 0.0067 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.198 0.198
Schistosoma mansoni endoplasmin 0.0024 0.006 0.006
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0078 0.0972 0.3003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.073 0.1693
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Echinococcus granulosus lamin 0.0053 0.0546 0.0523
Trypanosoma brucei cysteine peptidase C (CPC) 0.0075 0.0908 0.1758
Schistosoma mansoni ran 0.0042 0.0361 0.0361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0067 0.0067
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.1332 0.1332
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0067 0.0102
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0272 0.0653
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.419 1
Schistosoma mansoni hypothetical protein 0.0051 0.0501 0.0501
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0078 0.0972 0.2342
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0255 0.3953 0.3953
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0067 0.0023
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0361 0.0657
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0078 0.0972 0.3003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0884 0.0922
Onchocerca volvulus 0.01 0.1332 0.3464
Brugia malayi hypothetical protein 0.0035 0.0241 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0067 0.0102
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0067 0.0067
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0476 0.0453
Schistosoma mansoni endoplasmin 0.0024 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0057
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0025 0.0066 0.0042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0439 0.0415
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.198 0.196
Giardia lamblia Cathepsin B precursor 0.0075 0.0908 0.2792
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1332 0.2611
Loa Loa (eye worm) hypothetical protein 0.0036 0.0249 0.0225
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.345
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0419 0.4527
Mycobacterium tuberculosis Conserved protein 0.0073 0.0884 0.0922
Giardia lamblia Cathepsin L precursor 0.0025 0.0067 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1462 0.2872
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0067 0.0067
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.1098 0.3419
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.008 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.067 0.1278
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0046 0.0419 0.1055
Trypanosoma cruzi cruzipain precursor, putative 0.01 0.1332 0.2611
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0107 0.1462 0.345
Brugia malayi Cathepsin L-like precursor 0.01 0.1332 0.1724
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.008 0.0073
Schistosoma mansoni cathepsin s 0.0036 0.0249 0.0249
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1332 0.2611
Echinococcus granulosus heat shock protein 0.0024 0.006 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.0591 0.0568
Brugia malayi nuclear hormone receptor 0.0026 0.008 0.0073
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0123 0.0236
Echinococcus granulosus heat shock protein 90 0.0024 0.006 0.0035
Loa Loa (eye worm) fibroinase 0.01 0.1332 0.1311
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0613 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0361 0.0337
Echinococcus multilocularis snurportin 1 0.0613 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0884 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0123 0.0179
Loa Loa (eye worm) cathepsin B 0.0075 0.0908 0.0885
Giardia lamblia Cathepsin L-like protease 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0067 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.419 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0433 0.098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0884 0.0922
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0123 0.0236
Schistosoma mansoni coup transcription factor 0.0026 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.008 0.0073
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0107 0.1462 0.2872
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0361 0.0337
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0107 0.1462 0.1441
Plasmodium vivax SET domain protein, putative 0.003 0.016 0.033
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0292 0.4582 0.4582
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0204 0.3097 0.7374
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0067 0.0067
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0204 0.3097 0.7374
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.008 0.0055
Onchocerca volvulus 0.0241 0.372 1
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.008 0.008
Giardia lamblia Hypothetical protein 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.1098 0.2577
Echinococcus multilocularis geminin 0.0252 0.3912 0.3897
Giardia lamblia Cathepsin L precursor 0.0025 0.0067 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0042
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0067 0.0056
Plasmodium vivax unspecified product 0.0036 0.0249 0.0623
Brugia malayi Cathepsin L-like precursor 0.01 0.1332 0.1724
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0068 0.0791 0.0768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0272 0.0479
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0078 0.0972 0.0949
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0078 0.0972 0.1248
Brugia malayi Ets-domain containing protein 0.0072 0.0859 0.11
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0884 0.2062
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0204 0.3097 0.7374
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0361 0.099
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0476 0.0476
Trichomonas vaginalis heat shock protein, putative 0.0024 0.006 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0025 0.0067 0.0102
Plasmodium falciparum serine repeat antigen 7 0.0025 0.0067 0.0023
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0126 0.1772 0.5637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.067 0.1548
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0239 0.0283
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0476 0.1122
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.03 0.4722 0.4722
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0255 0.3953 0.3938
Loa Loa (eye worm) hypothetical protein 0.0053 0.0546 0.0523
Brugia malayi RNA, U transporter 1 0.0163 0.2405 0.3137
Trichomonas vaginalis ran, putative 0.0042 0.0361 0.0806
Giardia lamblia Cathepsin B precursor 0.0025 0.0067 0.0023
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0034 0.0009
Echinococcus multilocularis neutral alpha glucosidase AB 0.0028 0.0123 0.0099
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0977 0.2356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.073 0.1693
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0081 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0617 0.1172
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Schistosoma mansoni alpha-glucosidase 0.0109 0.1495 0.1495
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0107 0.1462 0.1441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Onchocerca volvulus Cathepsin L homolog 0.01 0.1332 0.3464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.008 0.0055
Plasmodium vivax geranylgeranyltransferase, putative 0.0078 0.0972 0.3003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.016 0.033
Brugia malayi Endoplasmin precursor 0.0024 0.006 0.0046
Brugia malayi cathepsin B-like cysteine proteinase 0.0186 0.2786 0.3639
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0107 0.1462 0.2872
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0272 0.0594
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0123 0.0236
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0859 0.0836
Plasmodium falciparum importin beta, putative 0.0057 0.0617 0.1833
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Loa Loa (eye worm) MBCTL1 0.0056 0.0591 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.008 0.0055
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.345
Giardia lamblia Cathepsin L-like protease 0.0025 0.0067 0.0023
Loa Loa (eye worm) hypothetical protein 0.0073 0.0884 0.0861
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0073 0.0884 0.0861
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0464
Schistosoma mansoni ran 0.0042 0.0361 0.0361
Leishmania major GTP-binding protein, putative 0.0042 0.0361 0.0895
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0123 0.0162
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.008 0.0055
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0255 0.3953 0.9431
Echinococcus granulosus intermediate filament protein 0.0053 0.0546 0.0523
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0025 0.0066 0.0055
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0025 0.0066 0.0042
Schistosoma mansoni cathepsin C 0.0025 0.0067 0.0067
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0025 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.008 0.0055
Echinococcus granulosus atrial natriuretic peptide receptor 0.0025 0.0066 0.0042
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.1098 0.2577
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0977 0.3021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0884 0.0861
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0067 0.0023
Toxoplasma gondii cathepsin CPL 0.01 0.1332 0.419
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0025 0.0066 0.0042
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0082 0.0057
Loa Loa (eye worm) ctsf protein 0.01 0.1332 0.1311
Loa Loa (eye worm) hypothetical protein 0.0064 0.073 0.0707
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0052 0.052 0.0653
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.198 0.196
Trypanosoma cruzi Heat shock protein 83, putative 0.0024 0.006 0.0052
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 0.0082 0.0075
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Onchocerca volvulus 0.0025 0.0067 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0241 0.0216
Brugia malayi cathepsin L precursor 0.0025 0.0067 0.0056
Echinococcus multilocularis cathepsin L 0.0025 0.0067 0.0042
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.0066 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.01 0.1332 0.3268
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.008 0.0055
Plasmodium falciparum serine repeat antigen 4 0.0025 0.0067 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0241 0.372 0.8872
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0078 0.0972 0.0972
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.067 0.085
Giardia lamblia Cathepsin B precursor 0.0075 0.0908 0.2792
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0476 0.0476
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0066 0.0042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0514 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0884 0.0884
Giardia lamblia Cathepsin B precursor 0.0025 0.0067 0.0023
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0476 0.0453
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0067 0.0023
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.3601
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Giardia lamblia Rab geranylgeranyltransferase 0.0107 0.1462 0.4617
Loa Loa (eye worm) hypothetical protein 0.0051 0.0514 0.049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.2872
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0884 0.0922
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.2872
Giardia lamblia Cysteine protease 0.0025 0.0067 0.0023
Loa Loa (eye worm) inositol-1 0.0037 0.0272 0.0248
Echinococcus granulosus glutamate receptor 2 0.0025 0.0066 0.0042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0046 0.0419 0.0395
Entamoeba histolytica cysteine proteinase 1, putative 0.0061 0.067 0.1566
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.033 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0591 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0977 0.3021
Entamoeba histolytica cysteine proteinase 2 0.0061 0.067 0.1566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0042
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0107 0.1462 0.1441
Schistosoma mansoni inositol monophosphatase 0.0037 0.0272 0.0272
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.067 0.1566
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.016 0.0136
Brugia malayi Cathepsin L-like precursor 0.0036 0.0249 0.0296
Brugia malayi cathepsin L-like precursor 0.0064 0.073 0.0929
Brugia malayi Cathepsin L-like cysteine proteinase 0.0064 0.073 0.0929
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0884 0.1709
Giardia lamblia Cathepsin L precursor 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0025 0.0067 0.0102
Brugia malayi nuclear receptor NHR-88 0.0026 0.008 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0224 0.0477
Trypanosoma cruzi protein farnesyltransferase, putative 0.0204 0.3097 0.616
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0034 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0546 0.0523
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0317 0.5006 0.6534
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 0.2786 0.2786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0078 0.0972 0.3003
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0107 0.1462 0.1894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.016 0.016
Entamoeba histolytica cysteine protease, putative 0.0025 0.0067 0.0018
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Echinococcus granulosus geminin 0.0252 0.3912 0.3897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.198 0.198
Brugia malayi hypothetical protein 0.0025 0.0066 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0067 0.0102
Brugia malayi beta-lactamase 0.0073 0.0884 0.1132
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.419 1
Brugia malayi beta-lactamase family protein 0.0073 0.0884 0.1132
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0102
Schistosoma mansoni lamin 0.0053 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Schistosoma mansoni hypothetical protein 0.0613 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0617 0.1833
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0067 0.0067
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0067 0.0023
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0067 0.0023
Plasmodium falciparum serine repeat antigen 1 0.0025 0.0067 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2788 0.6635
Loa Loa (eye worm) hypothetical protein 0.0241 0.3714 0.3698
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.419 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.016 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0884 0.2062
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.067 0.1278
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0066 0.0042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0081 0.0056
Giardia lamblia Cathepsin L precursor 0.0025 0.0067 0.0023
Giardia lamblia Cysteine protease 0.0025 0.0067 0.0023
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Onchocerca volvulus 0.0053 0.0546 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.008 0.0055
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0859 0.0836
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0067 0.0056
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.008 0.0055
Leishmania major cysteine peptidase A (CPA) 0.01 0.1332 0.356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.008 0.0055
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0107 0.1462 0.1441
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0078 0.0972 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Schistosoma mansoni inositol monophosphatase 0.0037 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Entamoeba histolytica hypothetical protein 0.0047 0.0433 0.0958
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.198 0.196
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.008 0.008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0075 0.0908 0.0908
Onchocerca volvulus 0.0053 0.0546 0.1313
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.0419 0.0289
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0123 0.0162
Echinococcus granulosus neutral alpha glucosidase AB 0.0028 0.0123 0.0099
Brugia malayi Receptor family ligand binding region containing protein 0.0068 0.0791 0.101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0067 0.0067
Loa Loa (eye worm) glutamate receptor 0.0104 0.1403 0.1381
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0078 0.0972 0.1886
Echinococcus granulosus cathepsin b 0.0186 0.2786 0.2768
Loa Loa (eye worm) beta-lactamase 0.0073 0.0884 0.0861
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.0419 0.0395
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0272 0.0479
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.3714 0.3698
Onchocerca volvulus Poor gastrulation protein homolog 0.0043 0.0371 0.0834
Plasmodium vivax vivapain-2 0.01 0.1332 0.419
Plasmodium falciparum serine repeat antigen 2 0.0025 0.0067 0.0023
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0433 0.098
Plasmodium falciparum serine repeat antigen 3 0.0025 0.0067 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1462 0.2872
Echinococcus multilocularis lysosomal alpha glucosidase 0.0127 0.1794 0.1774
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.008 0.0055
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.008 0.0055
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0067 0.0023
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0052 0.052 0.0497
Schistosoma mansoni hypothetical protein 0.0035 0.0241 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2788 0.6635
Loa Loa (eye worm) hypothetical protein 0.0064 0.073 0.0707
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0419 0.4527
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0025 0.0067 0.0023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0591 0.0568
Trypanosoma brucei heat shock protein 90, putative 0.0024 0.006 0.0052
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0476 0.0453
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0546 0.0687
Mycobacterium ulcerans beta-lactamase 0.0073 0.0884 1
Trichomonas vaginalis esterase, putative 0.0073 0.0884 0.2062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.016 0.016
Brugia malayi Cathepsin L-like precursor 0.0064 0.073 0.0929
Trypanosoma brucei glucosidase, putative 0.0028 0.0123 0.0179
Loa Loa (eye worm) hypothetical protein 0.0073 0.0884 0.0861
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0419 0.0419
Brugia malayi mbt repeat family protein 0.0049 0.0476 0.0595
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.008 0.008
Brugia malayi beta-lactamase family protein 0.0073 0.0884 0.1132
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0066 0.0055
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0129 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Brugia malayi Pre-SET motif family protein 0.003 0.016 0.0178
Brugia malayi Ets-domain containing protein 0.0072 0.0859 0.11
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0078 0.0972 0.3003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.016 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.067 0.1278
Onchocerca volvulus 0.0073 0.0884 0.2237
Leishmania major extracellular receptor, putative 0.0025 0.0066 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.016 0.016
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.1098 0.3419
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0272 0.0594
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0476 0.0476
Brugia malayi Papain family cysteine protease containing protein 0.01 0.1332 0.1724
Onchocerca volvulus 0.0026 0.008 0.0037
Brugia malayi Cathepsin L-like precursor 0.01 0.1332 0.1724
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.0249 0.0225
Entamoeba histolytica cysteine protease, putative 0.0025 0.0067 0.0018
Loa Loa (eye worm) endoplasmin 0.0024 0.006 0.0035
Brugia malayi ecdysteroid receptor 0.0026 0.008 0.0073
Schistosoma mansoni gabp alpha 0.0072 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0082 0.0057
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0028 0.0123 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0884 0.1709
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0292 0.4582 0.4569
Brugia malayi Inositol-1 0.0037 0.0272 0.0326
Loa Loa (eye worm) hypothetical protein 0.0036 0.0249 0.0225
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0123 0.0236
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.345
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.1332 0.3139
Plasmodium falciparum cysteine proteinase falcipain 2b 0.01 0.1332 0.419
Echinococcus granulosus tyrosine kinase 0.0025 0.0066 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.008 0.0055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0129 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0884 0.2713
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0107 0.1462 0.1441
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Loa Loa (eye worm) hypothetical protein 0.0078 0.0972 0.0949
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0241 0.0241
Giardia lamblia Encystation-specific protease 0.0025 0.0067 0.0023
Loa Loa (eye worm) fli-1 protein 0.0218 0.3327 0.331
Trypanosoma brucei lanosterol synthase 0.0317 0.5006 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0272 0.28
Loa Loa (eye worm) hypothetical protein 0.0043 0.0371 0.0347
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0272 0.0479
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.067 0.1566
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1332 0.2611
Brugia malayi Cathepsin L-like precursor 0.01 0.1332 0.1724
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0067 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0123 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.1332 0.3139
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.419 0.4176
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0361 0.0443
Brugia malayi Fli-1 protein 0.0218 0.3327 0.4353
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0025 0.0067 0.0023
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0107 0.1462 0.1441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.008 0.0055
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0361 0.0657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0123 0.013
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.033 0.0306
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0067 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0035 0.0239 0.0239
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0464
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Loa Loa (eye worm) hypothetical protein 0.0186 0.2786 0.2768
Mycobacterium ulcerans hypothetical protein 0.0073 0.0884 1
Loa Loa (eye worm) hypothetical protein 0.003 0.016 0.0136
Mycobacterium leprae Probable lipase LipE 0.0073 0.0884 1
Schistosoma mansoni metabotropic glutamate receptor 0.0221 0.3386 0.3386
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0034 0.0009
Onchocerca volvulus 0.0049 0.0476 0.1122
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Echinococcus multilocularis musashi 0.0053 0.0546 0.0523
Echinococcus multilocularis lamin 0.0053 0.0546 0.0523
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0067 0.0067
Toxoplasma gondii hypothetical protein 0.0107 0.1462 0.4617
Onchocerca volvulus 0.0073 0.0889 0.225
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.008 0.008
Loa Loa (eye worm) acetyltransferase 0.0292 0.4582 0.4569
Onchocerca volvulus Cathepsin F homolog 0.01 0.1332 0.3464
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.01 0.1332 0.1311
Plasmodium falciparum serine repeat antigen 9 0.0025 0.0067 0.0023
Schistosoma mansoni importin beta-1 0.0057 0.0617 0.0617
Onchocerca volvulus 0.01 0.1332 0.3464
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0204 0.3097 0.7374
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0204 0.3097 1
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0067 0.0056
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0025 0.0066 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0249 0.0225
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0272 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.008 0.0073
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0204 0.3097 1
Loa Loa (eye worm) cysteine protease 0.01 0.1332 0.1311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.008 0.0055
Mycobacterium tuberculosis Conserved protein 0.0073 0.0884 0.0922
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0067 0.0067
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0884 0.0922
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.008 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0025 0.0066 0.0042
Loa Loa (eye worm) hypothetical protein 0.0052 0.053 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.008 0.0073
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.067 0.1278
Giardia lamblia Rab geranylgeranyltransferase 0.0107 0.1462 0.4617
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0042
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0361 0.099
Giardia lamblia Cathepsin B precursor 0.0025 0.0067 0.0023
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.008 0.008
Plasmodium vivax unspecified product 0.0025 0.0067 0.0023
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0204 0.3097 0.4049
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0067 0.0018
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.033 0.033
Leishmania major lanosterol synthase, putative 0.0239 0.3681 1
Echinococcus granulosus glutamate receptor 2 0.0025 0.0066 0.0042
Plasmodium falciparum serine repeat antigen 8 0.0025 0.0067 0.0023
Echinococcus multilocularis cathepsin b 0.0186 0.2786 0.2768
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Trypanosoma cruzi lanosterol synthase, putative 0.0317 0.5006 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Giardia lamblia Prenyltransferase 0.0204 0.3097 1
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0255 0.3953 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0075 0.0908 0.212
Loa Loa (eye worm) hypothetical protein 0.0325 0.5142 0.5129
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.0577 0.0577
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0361 0.0337
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2916 0.2899
Schistosoma mansoni ets-related 0.0218 0.3327 0.3327
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.2786 0.5535
Echinococcus multilocularis cysteine protease 0.01 0.1332 0.1311
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.1098 0.1076
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.3714 0.3698
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.0577 0.0577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0419 0.4527
Echinococcus multilocularis cysteine protease 0.01 0.1332 0.1311
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.2628 0.701
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0067 0.0023
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0361 0.099
Giardia lamblia Hypothetical protein 0.0025 0.0067 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1462 0.2872
Entamoeba histolytica Ran family GTPase 0.0042 0.0361 0.0772
Brugia malayi acetyltransferase, GNAT family protein 0.0292 0.4582 0.6008
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0067 0.0023
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Loa Loa (eye worm) hypothetical protein 0.0107 0.1462 0.1441
Brugia malayi Pre-SET motif family protein 0.0212 0.3226 0.422
Echinococcus multilocularis heat shock protein 90 0.0024 0.006 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0067 0.0102
Echinococcus granulosus lamin dm0 0.0053 0.0546 0.0523
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0043 0.0371 0.0834
Schistosoma mansoni heat shock protein 0.0024 0.006 0.006
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0107 0.1462 0.4617
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0066 0.0066
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0107 0.1462 0.2872
Loa Loa (eye worm) hypothetical protein 0.0078 0.0972 0.0949
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0464
Brugia malayi Importin beta-1 subunit 0.0057 0.0617 0.078
Leishmania major geranylgeranyltransferase, putative 0.0078 0.0972 0.2571
Plasmodium vivax unspecified product 0.0061 0.067 0.2008
Plasmodium falciparum serine repeat antigen 5 0.0025 0.0067 0.0023
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0433 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Entamoeba histolytica cysteine protease, putative 0.0025 0.0067 0.0018
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0476 0.0453
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0025 0.0067 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0067 0.0102
Loa Loa (eye worm) heat shock protein 90 0.0024 0.006 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.008 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Trypanosoma brucei Heat shock protein 83, putative 0.0024 0.006 0.0052
Giardia lamblia Cysteine protease 0.0025 0.0067 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0123 0.0179
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2916 0.2899
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0204 0.3097 0.78
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0141 0.0117
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.008 0.0037
Entamoeba histolytica cysteine protease, putative 0.0025 0.0067 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0026 0.008 0.008
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0061 0.067 0.1278
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0204 0.3097 0.616
Echinococcus granulosus metabotropic glutamate receptor 2 0.0221 0.3386 0.3369
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0591 0.0591
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0272 0.0248
Loa Loa (eye worm) hypothetical protein 0.004 0.033 0.0306
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0025 0.0025
Mycobacterium tuberculosis Conserved protein 0.0073 0.0884 0.0922
Onchocerca volvulus Cathepsin L homolog 0.01 0.1332 0.3464
Echinococcus granulosus importin subunit beta 1 0.0057 0.0617 0.0593
Schistosoma mansoni hypothetical protein 0.0049 0.0476 0.0476
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0107 0.1462 0.1462
Plasmodium falciparum cysteine proteinase falcipain 3 0.01 0.1332 0.419
Trichomonas vaginalis sucrase-isomaltase, putative 0.0028 0.0123 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0972 0.1886
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0204 0.3097 0.3079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.008 0.0073
Echinococcus multilocularis tyrosine kinase 0.0025 0.0066 0.0042
Echinococcus multilocularis nmda type glutamate receptor 0.0025 0.0066 0.0042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0272 0.0594
Schistosoma mansoni hypothetical protein 0.0252 0.3912 0.3912
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0123 0.0236
Echinococcus granulosus sodium channel protein 0.0236 0.3643 0.3627
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.1332 0.1311
Echinococcus multilocularis cathepsin b 0.0186 0.2786 0.2768
Schistosoma mansoni protein kinase 0.0025 0.0066 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0514 0.0645
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Loa Loa (eye worm) glutamate receptor 0.0264 0.411 0.4096
Leishmania major hypothetical protein, conserved 0.0073 0.0884 0.2331
Loa Loa (eye worm) hypothetical protein 0.004 0.033 0.0306
Echinococcus granulosus FTZ F1 alpha 0.0026 0.008 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Echinococcus granulosus cathepsin l cysteine peptidase 0.01 0.1332 0.1311
Loa Loa (eye worm) hypothetical protein 0.0068 0.0791 0.0768
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0204 0.3097 0.7374
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0617 0.0593
Echinococcus multilocularis lysosomal alpha glucosidase 0.0127 0.1794 0.1774
Giardia lamblia Cathepsin B precursor 0.0075 0.0908 0.2792
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0067 0.0102
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0224 0.0477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.073 0.073
Trypanosoma cruzi extracellular receptor, putative 0.0025 0.0066 0.0065
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0361 0.099
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0236 0.3643 0.9897
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.016 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.008 0.0073
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Giardia lamblia Cathepsin B precursor 0.0025 0.0067 0.0023
Trypanosoma cruzi heat shock protein 85, putative 0.0024 0.006 0.0052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0476 0.0595
Trypanosoma cruzi protein farnesyltransferase, putative 0.0204 0.3097 0.616
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.1332 0.1332
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.067 0.067
Schistosoma mansoni hypothetical protein 0.0252 0.3912 0.3912
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.198 0.196
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0066 0.0042
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0361 0.0657
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Schistosoma mansoni heat shock protein 0.0024 0.006 0.006
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.033 0.0306
Plasmodium falciparum geranylgeranyltransferase, putative 0.0078 0.0972 0.3003
Brugia malayi mbt repeat family protein 0.0049 0.0476 0.0595
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0028 0.0123 0.0208
Loa Loa (eye worm) hypothetical protein 0.0064 0.073 0.0707
Giardia lamblia Cathepsin L precursor 0.0025 0.0067 0.0023
Onchocerca volvulus 0.0073 0.0884 0.2237
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0419 0.0419
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.1332 0.1311
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0067 0.0042
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0082 0.0057
Brugia malayi follicle stimulating hormone receptor 0.0471 0.7611 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0025 0.0066 0.0042
Brugia malayi Cathepsin L-like precursor 0.0064 0.073 0.0929
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0067 0.0067
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.033 0.0306
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0884 0.0922
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.008 0.008
Echinococcus multilocularis cathepsin L 0.0061 0.067 0.0646
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2628 0.6249
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.033 0.0403
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0884 0.2062
Brugia malayi Cathepsin L-like precursor 0.01 0.1332 0.1724
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.033 0.0306
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.0066 0.0042
Giardia lamblia Cathepsin L precursor 0.0025 0.0067 0.0023
Echinococcus granulosus cysteine protease 0.0061 0.067 0.0646
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.033 0.0306
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Onchocerca volvulus 0.01 0.1332 0.3464
Schistosoma mansoni nuclear hormone receptor 0.0026 0.008 0.008
Trypanosoma brucei heat shock protein 90, putative 0.0024 0.006 0.0052
Schistosoma mansoni hypothetical protein 0.0043 0.0371 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0102
Loa Loa (eye worm) hypothetical protein 0.0057 0.0617 0.0593
Loa Loa (eye worm) hypothetical protein 0.0061 0.0683 0.066
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.008 0.0055
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0204 0.3097 0.7374
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.1332 0.1311
Echinococcus granulosus cathepsin L 0.0061 0.067 0.0646
Loa Loa (eye worm) hypothetical protein 0.0073 0.0884 0.0861
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.198 0.196
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0067 0.0056
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0884 0.1132
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0107 0.1462 0.4617
Brugia malayi hypothetical protein 0.0241 0.3714 0.4862
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.008 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0884 0.1709
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0067 0.0042
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0249 0.0296
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0078 0.0972 0.2273
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0476 0.0453
Plasmodium vivax vivapain-2 0.01 0.1332 0.419
Plasmodium vivax importin-beta 2, putative 0.0057 0.0617 0.1833
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0591 0.0747
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.0419 0.1182
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0249 0.0296
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0025 0.0066 0.0042
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0859 0.0836
Trypanosoma cruzi lanosterol synthase, putative 0.0317 0.5006 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0025 0.0067 0.0102
Leishmania major farnesyltransferase beta subunit 0.0204 0.3097 0.8398
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0025 0.0066 0.0042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.198 0.2577
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0078 0.0972 0.2273
Echinococcus granulosus cathepsin L 0.0025 0.0067 0.0042
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0067 0.0056
Echinococcus granulosus lysosomal alpha glucosidase 0.0127 0.1794 0.1774
Echinococcus granulosus nmda type glutamate receptor 0.0025 0.0066 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.008 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Leishmania major importin beta-1 subunit, putative 0.0047 0.0433 0.1094
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0067 0.0056
Echinococcus granulosus cathepsin L cysteine protease 0.0061 0.067 0.0646
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0123 0.0236
Brugia malayi steroid hormone receptor 0.0026 0.008 0.0073
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0025 0.0066 0.0042
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0107 0.1462 0.3601
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.2786 0.2786
Entamoeba histolytica cysteine protease, putative 0.0025 0.0067 0.0018
Schistosoma mansoni tyrosine kinase 0.0025 0.0066 0.0066
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0249 0.0433
Trypanosoma cruzi cysteine protease, putative 0.0061 0.067 0.1278
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0025 0.0025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.1332 0.1311
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.067 0.067
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.419 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0042
Onchocerca volvulus 0.003 0.016 0.0256
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0236 0.3643 0.3627
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.073 0.14
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.067 0.1278
Plasmodium vivax vivapain-1 0.0061 0.067 0.2008
Onchocerca volvulus 0.0073 0.0884 0.2237
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0107 0.1462 0.1441
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.008 0.0073
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0068 0.0791 0.0768
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.1098 0.3419
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0067 0.0018
Schistosoma mansoni intermediate filament proteins 0.0053 0.0546 0.0546
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0617 0.1172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0107 0.1462 0.4617
Entamoeba histolytica hypothetical protein 0.0025 0.0066 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.008 0.0073
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0025 0.0066 0.0042
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0884 0.0922
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0042
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0272 0.0248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0471 0.7611 0.7605
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.0215
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0082 0.0057
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0255 0.3953 0.3953
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0972 0.1886
Brugia malayi metabotropic glutamate receptor type 2 0.0129 0.1822 0.2369
Echinococcus granulosus cathepsin l1 0.01 0.1332 0.1311
Echinococcus granulosus histone acetyltransferase KAT2B 0.0284 0.4444 0.443
Echinococcus multilocularis lamin dm0 0.0053 0.0546 0.0523
Mycobacterium ulcerans lipase LipD 0.0073 0.0884 1
Plasmodium falciparum serine repeat antigen 6 0.0025 0.0067 0.0023
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Schistosoma mansoni hypothetical protein 0.0298 0.469 0.469
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0127 0.1794 0.1774
Entamoeba histolytica cysteine proteinase, putative 0.01 0.1332 0.3268
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.419 1
Onchocerca volvulus 0.01 0.1332 0.3464
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.008 0.0073
Schistosoma mansoni lamin 0.0053 0.0546 0.0546
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0025 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.008 0.008
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0067 0.0023
Brugia malayi intermediate filament protein 0.0053 0.0546 0.0687
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.2786 0.2786
Echinococcus multilocularis heat shock protein 0.0024 0.006 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1332 0.2611
Toxoplasma gondii cathepsin CPC1 0.0025 0.0067 0.0023
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0591 0.0568
Onchocerca volvulus 0.0107 0.1462 0.3819
Toxoplasma gondii cathepsin CPC2 0.0025 0.0067 0.0023
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0272 0.5
Brugia malayi Cathepsin L-like precursor 0.01 0.1332 0.1724
Giardia lamblia Rab geranylgeranyltransferase 0.0078 0.0972 0.3003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0241 0.0216
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0255 0.3953 0.3938
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0884 0.2062
Brugia malayi fibroinase precursor 0.0025 0.0067 0.0056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0476 0.0453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.1332 0.3139
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0514 0.049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.3226 0.3209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.2786 0.2786
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.008 0.0055
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0067 0.0042
Toxoplasma gondii ABC1 family protein 0.0073 0.0884 0.2713
Echinococcus granulosus GPCR family 3 C terminal 0.0043 0.0371 0.0347
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.008 0.0055
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0884 0.0922
Onchocerca volvulus 0.01 0.1332 0.3464
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0067 0.0023
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0107 0.1462 0.1441
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0102
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0107 0.1462 0.3916
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0067 0.0102
Plasmodium vivax vivapain-3 0.0061 0.067 0.2008
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0067 0.0002
Trypanosoma cruzi heat shock protein 85, putative 0.0024 0.006 0.0052
Onchocerca volvulus 0.0049 0.0476 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Trypanosoma cruzi heat shock protein 85, putative 0.0024 0.006 0.0052
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.0066 0.0042
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.419 0.5491
Schistosoma mansoni alpha-glucosidase 0.0109 0.1495 0.1495
Brugia malayi heat shock protein 90 0.0024 0.006 0.0046
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0255 0.3953 0.5178
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Entamoeba histolytica cysteine protease, putative 0.0061 0.067 0.1566
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0026 0.008 0.008
Entamoeba histolytica cysteine protease, putative 0.01 0.1332 0.3268
Trypanosoma brucei heat shock protein, putative 0.0024 0.006 0.0052
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0591 0.0568
Echinococcus granulosus cathepsin b 0.0186 0.2786 0.2768
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.008 0.0055
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0067 0.0056
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0255 0.3953 0.3938
Leishmania major heat shock protein 83-1 0.0024 0.006 0.0071
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0204 0.3097 0.3097
Schistosoma mansoni tyrosine kinase 0.0025 0.0066 0.0066
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0075 0.0908 0.1758
Brugia malayi Cytochrome P450 family protein 0.0023 0.0034 0.0012
Trypanosoma cruzi heat shock protein 90, putative 0.0024 0.006 0.0052
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0067 0.0056
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0221 0.3386 0.3369
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0052 0.052 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.067 0.1566
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.008 0.0055
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0067 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0067 0.0102
Brugia malayi Glycosyl hydrolases family 31 protein 0.0127 0.1794 0.2332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.1332 0.3139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.008 0.008
Plasmodium falciparum cysteine proteinase falcipain 2a 0.01 0.1332 0.419
Echinococcus multilocularis sodium channel protein 0.0236 0.3643 0.3627
Leishmania major cathepsin L-like protease 0.01 0.1332 0.356
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.067 0.1566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0884 0.0884
Echinococcus multilocularis GPCR, family 3, C terminal 0.0043 0.0371 0.0347
Onchocerca volvulus 0.0064 0.073 0.1816
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0433 0.0803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.008 0.0055
Schistosoma mansoni survival motor neuron protein 0.0049 0.0476 0.0476

Activities

Activity type Activity value Assay description Source Reference
Cl (ADMET) = 43 ml min-1 kg-1 Total clearance of the compound was determined in rats ChEMBL. 15341947
F (ADMET) = 38 % Oral bioavailability in rat ChEMBL. 15341947
FS-SIF (ADMET) = 0.09 mg ml-1 Equilibrium solubility in fasted state-simulated intestinal fluid was determined in rats ChEMBL. 15341947
IC50 (binding) = 13 nM Inhibition of 10 uM Cbz-Phe-Arg-AMC binding to human cathepsin K in fluorescence assay ChEMBL. 15341947
IC50 (binding) = 13 nM Inhibition of 10 uM Cbz-Phe-Arg-AMC binding to human cathepsin K in fluorescence assay ChEMBL. 15341947
IC50 (binding) = 27 nM Inhibition of 10 uM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assay ChEMBL. 15341947
IC50 (binding) = 27 nM Inhibition of 10 uM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assay ChEMBL. 15341947
IC50 (binding) = 680 nM Inhibition of 5 uM Cbz-Phe-Arg-AMC human cathepsin L in fluorescence assay ChEMBL. 15341947
IC50 (binding) = 680 nM Inhibition of 5 uM Cbz-Phe-Arg-AMC human cathepsin L in fluorescence assay ChEMBL. 15341947
IC50 (binding) > 5000 nM Inhibition of 10 uM Cbz-Phe-Arg-AMC binding to human cathepsin B in fluorescence assay ChEMBL. 15341947
IC50 (binding) > 5000 nM Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay ChEMBL. 15341947
IC50 (binding) > 5000 nM Inhibition of 10 uM Cbz-Phe-Arg-AMC binding to human cathepsin B in fluorescence assay ChEMBL. 15341947
IC50 (binding) > 5000 nM Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay ChEMBL. 15341947
Papp (ADMET) = 470 nM/s Apparent permeability coefficient for apical to basoplateral flux was determined by Madin-Darby canine kidney cell monolayer transport assay ChEMBL. 15341947
Ratio (binding) = 2.1 Relative binding to human cathepsins S and K ChEMBL. 15341947
Ratio (binding) = 28 Relative binding to human cathepsins L and K ChEMBL. 15341947
Ratio (binding) > 200 Relative binding to human cathepsins B and K ChEMBL. 15341947
Ratio (binding) > 200 Relative binding to human cathepsins L and K ChEMBL. 15341947
T1/2 (ADMET) = 110 min Terminal half-life was determined in rats upon intravenous administration as a solution in 40% hydroxypropyl-b-cyclodextrin, pH = 5.1 ChEMBL. 15341947
Vss (ADMET) = 4200 ml kg-1 Steady state volume of distribution of the compound was determined in rats ChEMBL. 15341947

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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