Detailed information for compound 416303

Basic information

Technical information
  • TDR Targets ID: 416303
  • Name: 00652_FLUKA
  • MW: 185.948 | Formula: C2H3IO2
  • H donors: 1 H acceptors: 2 LogP: 0.47 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CI
  • InChi: 1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
  • InChiKey: JDNTWHVOXJZDSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-iodoacetic acid
  • 2-iodoethanoic acid
  • 4-02-00-00534 (Beilstein Handbook Reference)
  • 64-69-7
  • Acetic acid, iodo- (8CI,9CI)
  • Acetic acid, iodo-
  • AI3-52119
  • BRN 1739079
  • CCRIS 667
  • EINECS 200-590-1
  • HSDB 4008
  • I4386_SIAL
  • IA
  • Iodoacetates
  • Iodoacetic Acid
  • Kyselina jodoctova [Czech]
  • MIA
  • Monoiodine acetate
  • Monoiodoacetate
  • Monoiodoacetic acid
  • NSC 2125
  • NSC2125
  • sJPhLQVIKTp@
  • STK263695
  • WLN: QV1I

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major pyroglutamyl-peptidase I (C15 family) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major pyroglutamyl-peptidase I (C15 family) Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma cruzi pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Leishmania infantum pyroglutamyl-peptidase I (PGP), putative Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 Get druggable targets OG5_150045 All targets in OG5_150045
Leishmania mexicana pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative Get druggable targets OG5_150045 All targets in OG5_150045
Leishmania braziliensis pyroglutamyl-peptidase I (PGP), putative Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma brucei pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma brucei gambiense pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative Get druggable targets OG5_150045 All targets in OG5_150045
Leishmania donovani pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0036 0.0018 0.0214
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0042 0.0042
Brugia malayi Pyruvate kinase, M2 isozyme 0.0103 0.0133 0.1634
Loa Loa (eye worm) hypothetical protein 0.004 0.0024 0.0298
Brugia malayi steroid hormone receptor 0.0052 0.0045 0.0527
Echinococcus multilocularis transfer RNA-Lys 0.0074 0.0083 0.0083
Onchocerca volvulus 0.0052 0.0045 0.0732
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0031 0.0009 0.0082
Schistosoma mansoni hypothetical protein 0.0074 0.0084 0.0336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0158 0.1855
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0158 0.1816
Mycobacterium leprae Probable pyruvate kinase PykA 0.0103 0.0133 1
Echinococcus multilocularis zinc finger protein 0.0044 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0045 0.0527
Leishmania major DNA polymerase eta, putative 0.0168 0.0245 0.2879
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0002 0.001
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0238 0.098
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0002 0.0031
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0045 0.0557
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0018 0.048
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0209 0.0316 0.129
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0045 0.0732
Trypanosoma brucei DNA polymerase eta, putative 0.0168 0.0245 0.2845
Loa Loa (eye worm) hypothetical protein 0.009 0.0111 0.1382
Brugia malayi calpain 7 0.0059 0.0057 0.0688
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0034 0.0399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0045 0.0183
Schistosoma mansoni hypothetical protein 0.01 0.0128 0.0516
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0117 0.0158 0.1855
Schistosoma mansoni hypothetical protein 0.017 0.0249 0.1017
Entamoeba histolytica hypothetical protein 0.0074 0.0084 0.471
Leishmania major DNA polymerase eta, putative 0.0087 0.0105 0.1238
Brugia malayi Bromodomain containing protein 0.0154 0.0222 0.2747
Schistosoma mansoni cpg binding protein 0.0098 0.0125 0.0506
Echinococcus granulosus calpain A 0.0209 0.0316 0.1299
Schistosoma mansoni hypothetical protein 0.0285 0.0448 0.1836
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Echinococcus multilocularis GPCR, family 2 0.0078 0.0091 0.0091
Schistosoma mansoni alpha glucosidase 0.0036 0.0018 0.0064
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0067 0.0811
Brugia malayi hypoxia-induced factor 1 0.0308 0.0487 0.6072
Onchocerca volvulus Pyruvate kinase homolog 0.0103 0.0133 0.2182
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0036 0.014
Echinococcus multilocularis pyruvate kinase 0.0053 0.0046 0.0046
Onchocerca volvulus 0.0085 0.0103 0.1689
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0074 0.5535
Leishmania major hypothetical protein, conserved 0.003 0.0008 0.0093
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0172 0.07
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0045 0.0173
Trypanosoma cruzi DNA polymerase eta, putative 0.0168 0.0245 0.2879
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0095 0.1074
Echinococcus granulosus GPCR family 2 0.0078 0.0091 0.0374
Loa Loa (eye worm) MBCTL1 0.0053 0.0048 0.0595
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0201 0.0828
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.0275 0.1131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0036 0.0455
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0005 0.0064
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0209 0.0316 0.129
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0018 0.048
Entamoeba histolytica pyruvate kinase, putative 0.0072 0.0079 0.4367
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0018 0.0075
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0103 0.0133 0.3383
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0018 0.0483
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0172 0.0709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.0384 0.4776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Echinococcus granulosus cpg binding protein 0.0098 0.0125 0.0516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0031
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0036 0.015
Trichomonas vaginalis pyruvate kinase, putative 0.0103 0.0133 0.3524
Leishmania major DNA polymerase kappa, putative 0.0036 0.0018 0.0214
Echinococcus granulosus calpain A 0.0059 0.0057 0.0236
Echinococcus multilocularis pyruvate kinase 0.0053 0.0046 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0084 0.0345
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0201 0.2491
Giardia lamblia DINP protein human, muc B family 0.0117 0.0158 1
Brugia malayi TAR-binding protein 0.0065 0.0067 0.0811
Loa Loa (eye worm) hypothetical protein 0.0078 0.0091 0.1135
Echinococcus multilocularis pyruvate kinase 0.0053 0.0046 0.0046
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0018 0.048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0018 0.0018
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0018 0.0557
Echinococcus granulosus dnaJ subfamily B 0.0862 0.1443 0.5937
Echinococcus multilocularis calpain A 0.0209 0.0316 0.0316
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0014 0.0057
Loa Loa (eye worm) beta-lactamase 0.0036 0.0018 0.0228
Loa Loa (eye worm) hypothetical protein 0.0378 0.0609 0.7604
Schistosoma mansoni hypothetical protein 0.0078 0.0091 0.0364
Echinococcus multilocularis pyruvate kinase 0.0081 0.0095 0.0095
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0018 0.0074
Loa Loa (eye worm) pyruvate kinase 0.0103 0.0133 0.1659
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0018 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0199 0.0298 0.1218
Trypanosoma brucei calpain-like protein, putative 0.0059 0.0057 0.0629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0201 0.0819
Echinococcus multilocularis lamin 0.0085 0.0103 0.0103
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0011 0.0108
Plasmodium vivax SET domain protein, putative 0.0032 0.0011 0.0574
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0045 0.0527
Schistosoma mansoni alpha-glucosidase 0.0141 0.0199 0.0808
Brugia malayi mbt repeat family protein 0.0047 0.0036 0.0425
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0209 0.0316 0.1299
Trypanosoma cruzi ISWI complex protein 0.003 0.0008 0.0093
Trypanosoma brucei calpain-like protein, putative 0.0059 0.0057 0.0629
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0045 0.0173
Schistosoma mansoni pyruvate kinase 0.0103 0.0133 0.0537
Loa Loa (eye worm) hypothetical protein 0.0084 0.01 0.1251
Onchocerca volvulus 0.009 0.011 0.1806
Loa Loa (eye worm) hypothetical protein 0.049 0.0801 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0014 0.0047
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0018 0.0196
Leishmania major pyruvate kinase 0.0103 0.0133 0.1561
Echinococcus multilocularis geminin 0.017 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0168 0.0245 0.3061
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0091 0.1107
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0067 0.0267
Echinococcus multilocularis calpain 7 (C02 family) 0.0059 0.0057 0.0057
Echinococcus multilocularis lamin dm0 0.0085 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.017 0.0249 0.1017
Schistosoma mansoni hypothetical protein 0.017 0.0248 0.1012
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0018 0.0557
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0117 0.0158 0.4188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0045 0.0527
Toxoplasma gondii hypothetical protein 0.0049 0.004 0.1409
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.0363 0.4536
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0018 0.0483
Brugia malayi ImpB/MucB/SamB family protein 0.0168 0.0245 0.3039
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0103 0.1257
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0231 0.6291
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0519 0.0851 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0045 0.0732
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0018 0.0167
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0862 0.1443 0.5933
Loa Loa (eye worm) pyruvate kinase-PB 0.0072 0.0079 0.0989
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0479 0.5633
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0201 0.0201
Schistosoma mansoni cpg binding protein 0.009 0.011 0.0443
Trypanosoma brucei glucosidase, putative 0.0036 0.0018 0.0166
Brugia malayi MH2 domain containing protein 0.0236 0.0363 0.4519
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0045 0.0173
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0203 0.239
Brugia malayi calpain family protein 1 0.0199 0.0298 0.3705
Schistosoma mansoni pyruvate kinase 0.0103 0.0133 0.0537
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0087 0.2317
Echinococcus multilocularis dna polymerase eta 0.0168 0.0245 0.0245
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0158 0.1855
Brugia malayi beta-lactamase family protein 0.0036 0.0018 0.0197
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0087 0.0105 0.3984
Trypanosoma brucei unspecified product 0.0117 0.0158 0.1816
Brugia malayi calpain family protein 1 0.0199 0.0298 0.3705
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0045 0.0527
Echinococcus granulosus survival motor neuron protein 1 0.049 0.0801 0.3295
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0018 0.0552
Echinococcus multilocularis neuropeptide receptor A26 0.0966 0.1622 0.1622
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0018 0.0226
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0011 0.0011
Trypanosoma brucei antigen, putative 0.0059 0.0057 0.0629
Entamoeba histolytica deoxycytidyl transferase, putative 0.0117 0.0158 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0087 0.4955
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0045 0.0173
Loa Loa (eye worm) calpain 0.0059 0.0057 0.0716
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0042 0.0171
Onchocerca volvulus Huntingtin homolog 0.0378 0.0609 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0172 0.0172
Onchocerca volvulus Pyruvate kinase homolog 0.0103 0.0133 0.2182
Entamoeba histolytica hypothetical protein 0.0074 0.0084 0.471
Echinococcus multilocularis snurportin 1 0.0301 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0085 0.0103 0.1284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0172 0.7232
Brugia malayi hypothetical protein 0.049 0.0801 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0045 0.0527
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.011 0.1373
Brugia malayi hypothetical protein 0.0334 0.0532 0.6632
Loa Loa (eye worm) hypothetical protein 0.0076 0.0087 0.1088
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0238 0.0238
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0045 0.0527
Schistosoma mansoni zinc finger protein 0.0044 0.0031 0.0119
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0014 0.0014
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.0475 0.5936
Brugia malayi Inositol-1 0.0076 0.0087 0.1064
Plasmodium falciparum pyruvate kinase 0.0103 0.0133 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0018 0.048
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0045 0.0183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0117 0.0158 0.0158
Loa Loa (eye worm) calpain family protein 1 0.0199 0.0298 0.3724
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0036 0.0036
Leishmania major pyruvate kinase 0.0103 0.0133 0.1561
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0059 0.0057 0.0674
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0018 0.0167
Trypanosoma brucei calpain-like protein, putative 0.0059 0.0057 0.0629
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0238 0.2974
Echinococcus multilocularis dna polymerase kappa 0.0117 0.0158 0.0158
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0117 0.0158 0.4123
Schistosoma mansoni cpg binding protein 0.0098 0.0125 0.0506
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0045 0.0527
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0169 0.0696
Brugia malayi Zinc finger, C2H2 type family protein 0.0316 0.0502 0.6252
Onchocerca volvulus 0.0095 0.0119 0.1952
Brugia malayi mbt repeat family protein 0.0047 0.0036 0.0425
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0091 0.1107
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0045 0.0527
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0045 0.0045
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.0479 0.5633
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0248 0.3078
Loa Loa (eye worm) hypoxia-induced factor 1 0.0308 0.0487 0.6084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0045 0.0183
Mycobacterium ulcerans hypothetical protein 0.016 0.0231 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0045 0.0531
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0042 0.0161
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0209 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0066 0.007 0.0874
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0326 0.4075
Schistosoma mansoni aryl hydrocarbon receptor 0.01 0.0127 0.0514
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0172 0.455
Echinococcus multilocularis musashi 0.0085 0.0103 0.0103
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0036 0.014
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0027 0.0109
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0048 0.0196
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0018 0.0167
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Schistosoma mansoni calpain-7 (C02 family) 0.0059 0.0057 0.0226
Schistosoma mansoni hypothetical protein 0.0078 0.0091 0.0364
Trypanosoma cruzi kinesin, putative 0.0059 0.0057 0.0674
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0018 0.0483
Plasmodium falciparum pyruvate kinase 2 0.0053 0.0046 0.3292
Echinococcus granulosus neuropeptide s receptor 0.0966 0.1622 0.6676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0201 0.0201
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0045 0.0045
Schistosoma mansoni DNA polymerase IV / kappa 0.0036 0.0018 0.0065
Schistosoma mansoni hypothetical protein 0.0078 0.0091 0.0364
Trypanosoma brucei chrX additional, unordered contigs 0.0036 0.0018 0.0167
Entamoeba histolytica calpain large subunit domain III containing protein 0.0059 0.0057 0.2808
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0045 0.0527
Schistosoma mansoni single-minded 0.01 0.0127 0.0514
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0018 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0018 0.0212
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0117 0.0158 0.065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.0384 0.4792
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0629
Echinococcus multilocularis calpain family protein 1, d 0.0139 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0045 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0067 0.0267
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0128 0.157
Loa Loa (eye worm) hypothetical protein 0.017 0.0248 0.3099
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0045 0.0173
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0045 0.0183
Brugia malayi PAS domain containing protein 0.01 0.0127 0.1562
Echinococcus granulosus zinc finger protein 0.0044 0.0031 0.0129
Brugia malayi bHLH-PAS transcription factor 0.0074 0.0083 0.1003
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0018 0.0214
Brugia malayi RNA binding protein 0.0065 0.0067 0.0811
Loa Loa (eye worm) pyruvate kinase 0.0103 0.0133 0.1659
Brugia malayi polk-prov protein 0.0036 0.0018 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0045 0.0527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0045 0.0183
Onchocerca volvulus 0.0036 0.0018 0.0299
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0045 0.0173
Schistosoma mansoni DNA polymerase eta 0.0168 0.0245 0.0999
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0172 0.07
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0519 0.0851 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0172 0.7232
Echinococcus granulosus single minded 2 0.0074 0.0083 0.034
Echinococcus multilocularis pyruvate kinase 0.0103 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0024 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0158 0.1816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0045 0.0557
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0031
Brugia malayi CXXC zinc finger family protein 0.009 0.011 0.1346
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0045 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0238 0.0238
Brugia malayi Pre-SET motif family protein 0.0215 0.0326 0.4057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0334 0.0532 0.6642
Plasmodium vivax pyruvate kinase 2, putative 0.0053 0.0046 0.3292
Brugia malayi nuclear receptor NHR-88 0.0052 0.0045 0.0527
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0045 0.0557
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0087 0.1027
Brugia malayi PHD-finger family protein 0.0055 0.005 0.0592
Leishmania major DNA polymerase kappa, putative 0.0117 0.0158 0.1855
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0045 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0067 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0045 0.0557
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0048 0.0186
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0087 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Schistosoma mansoni calpain (C02 family) 0.0059 0.0057 0.0226
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0158 0.1816
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0091 0.0374
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0045 0.0527
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0045 0.0173
Echinococcus multilocularis pyruvate kinase 0.0103 0.0133 0.0133
Brugia malayi beta-lactamase family protein 0.0036 0.0018 0.0197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0091 0.1135
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0074 0.1632
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0002 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.1433 0.243 1
Echinococcus granulosus calpain 5 0.0059 0.0057 0.0236
Trichomonas vaginalis esterase, putative 0.0036 0.0018 0.0483
Echinococcus granulosus microtubule associated protein 2 0.1433 0.243 1
Onchocerca volvulus 0.0085 0.0103 0.1689
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0103 0.1284
Brugia malayi calpain 5 0.0059 0.0057 0.0688
Onchocerca volvulus 0.0036 0.0018 0.0299
Loa Loa (eye worm) zinc finger protein 0.0316 0.0502 0.6264
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0018 0.048
Schistosoma mansoni terminal deoxycytidyl transferase 0.0117 0.0158 0.064
Brugia malayi hypothetical protein 0.0378 0.0609 0.7597
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0201 0.2514
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.0384 0.4776
Echinococcus granulosus geminin 0.017 0.0249 0.1026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0201 0.0819
Loa Loa (eye worm) hypothetical protein 0.0199 0.0298 0.3724
Echinococcus granulosus pyruvate kinase 0.0103 0.0133 0.0547
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0087 0.1027
Echinococcus granulosus snurportin 1 0.0301 0.0475 0.1956
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0018 0.048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0175 0.0258 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.0067 0.084
Echinococcus multilocularis calpain 5 0.0059 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0074 0.0084 0.471
Brugia malayi beta-lactamase 0.0036 0.0018 0.0197
Schistosoma mansoni lamin 0.0085 0.0103 0.0413
Schistosoma mansoni inositol monophosphatase 0.0076 0.0087 0.035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0059 0.0057 0.0674
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0018 0.0212
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0011 0.0291
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0169 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0045 0.0527
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0029 0.0295
Mycobacterium leprae Probable lipase LipE 0.0036 0.0018 0.1372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0045 0.0557
Schistosoma mansoni alpha-glucosidase 0.0141 0.0199 0.0808
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0479 0.5633
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0519 0.0851 1
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0026 0.0327
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0117 0.0158 0.1972
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0117 0.0158 0.064
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0103 0.1284
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0045 0.0173
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0048 0.0196
Brugia malayi Bromodomain containing protein 0.0076 0.0087 0.1058
Trypanosoma brucei ISWI complex protein 0.003 0.0008 0.0045
Schistosoma mansoni inositol monophosphatase 0.0076 0.0087 0.035
Schistosoma mansoni intermediate filament proteins 0.0085 0.0103 0.0413
Echinococcus granulosus lamin 0.0085 0.0103 0.0423
Trypanosoma cruzi pyruvate kinase 2, putative 0.0103 0.0133 0.1561
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0203 0.239
Echinococcus multilocularis calpain 0.0059 0.0057 0.0057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0067 0.084
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0018 0.0483
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0045 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0862 0.1443 0.1443
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0031
Trypanosoma cruzi pyruvate kinase 2, putative 0.0103 0.0133 0.1561
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0059 0.0057 0.0674
Trypanosoma brucei pyruvate kinase 1, putative 0.0103 0.0133 0.1521
Echinococcus granulosus intermediate filament protein 0.0085 0.0103 0.0423
Loa Loa (eye worm) pyruvate kinase 0.0103 0.0133 0.1659
Brugia malayi RNA, U transporter 1 0.008 0.0094 0.1145
Echinococcus granulosus calpain 7 C02 family 0.0059 0.0057 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0045 0.0527
Loa Loa (eye worm) hypothetical protein 0.0199 0.0298 0.3724
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Plasmodium vivax calpain, putative 0.0059 0.0057 0.4138
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0172 0.2025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.007 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0095 0.1074
Echinococcus granulosus neuropeptide receptor A26 0.0966 0.1622 0.6676
Trichomonas vaginalis DNA polymerase eta, putative 0.0117 0.0158 0.4188
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0011 0.0037
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0045 0.0732
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Echinococcus granulosus zinc finger transcription factor gli2 0.0316 0.0502 0.2064
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0158 0.6553
Trypanosoma brucei calpain-like protein, putative 0.0059 0.0057 0.0629
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0045 0.0045
Echinococcus granulosus dna polymerase eta 0.0168 0.0245 0.1008
Schistosoma mansoni pyruvate kinase 0.0053 0.0046 0.0181
Echinococcus multilocularis neuropeptide s receptor 0.0966 0.1622 0.1622
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0079 0.0324
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0285 0.1165
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0018 0.0167
Loa Loa (eye worm) hypothetical protein 0.0081 0.0095 0.119
Loa Loa (eye worm) inositol-1 0.0076 0.0087 0.1091
Loa Loa (eye worm) hypothetical protein 0.0053 0.0048 0.0595
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0357 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0045 0.0557
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0036 0.0455
Schistosoma mansoni hypothetical protein 0.0078 0.0091 0.0364
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Echinococcus granulosus pyruvate kinase 0.0053 0.0046 0.0191
Onchocerca volvulus 0.0139 0.0196 0.3222
Loa Loa (eye worm) hypothetical protein 0.0103 0.0133 0.1659
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0095 0.1074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.007 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0018 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0045 0.0045
Trypanosoma cruzi DNA polymerase eta, putative 0.0087 0.0105 0.1238
Giardia lamblia Pyruvate kinase 0.0053 0.0046 0.2022
Mycobacterium ulcerans putative regulatory protein 0.0074 0.0083 0.3016
Loa Loa (eye worm) hypothetical protein 0.0139 0.0196 0.245
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0087 0.3244
Brugia malayi Pyruvate kinase, muscle isozyme 0.0103 0.0133 0.1634
Loa Loa (eye worm) hypothetical protein 0.0072 0.0079 0.0989
Onchocerca volvulus 0.0047 0.0036 0.0598
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0018 0.0228
Loa Loa (eye worm) hypothetical protein 0.0378 0.0609 0.7604
Giardia lamblia Pyruvate kinase 0.0103 0.0133 0.8207
Entamoeba histolytica hypothetical protein 0.0074 0.0084 0.471
Toxoplasma gondii ABC1 family protein 0.0036 0.0018 0.0558
Schistosoma mansoni hypothetical protein 0.0301 0.0475 0.1948
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0331
Brugia malayi Pre-SET motif family protein 0.0032 0.0011 0.0112
Trypanosoma brucei unspecified product 0.0081 0.0095 0.1074
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0087 0.0087
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0079 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0172 0.7232
Plasmodium falciparum DNA repair protein REV1, putative 0.0036 0.0018 0.11
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0018 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0158 0.1855
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0018 0.0214
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0045 0.0173
Echinococcus multilocularis microtubule associated protein 2 0.1433 0.243 0.243
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0141 0.0198 0.2476
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0067 0.0267
Trichomonas vaginalis set domain proteins, putative 0.0244 0.0377 1
Echinococcus multilocularis zinc finger transcription factor gli2 0.0316 0.0502 0.0502
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0201 0.0828
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0045 0.0045
Schistosoma mansoni calpain-7 (C02 family) 0.0059 0.0057 0.0226
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0018 0.0214
Onchocerca volvulus 0.0074 0.0083 0.1355
Echinococcus granulosus pyruvate kinase 0.0103 0.0133 0.0547
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0158 0.6553
Echinococcus granulosus lamin dm0 0.0085 0.0103 0.0423
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0045 0.0045
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0018 0.0212
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.007 0.0288
Loa Loa (eye worm) calpain family protein 1 0.0139 0.0196 0.245
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0018 0.0167
Toxoplasma gondii pyruvate kinase PyK1 0.0103 0.0133 0.5066
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0031
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0027 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.0103 0.0133 0.2182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0018 0.0065
Onchocerca volvulus 0.0244 0.0377 0.6193
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0018 0.0483
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0018 0.0214
Trypanosoma brucei kinesin, putative 0.0059 0.0057 0.0629
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0084 0.0336
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0203 0.2353
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0172 0.6621
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0158 0.4123
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0048 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0201 0.0819
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0011 0.0037
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0036 0.0598
Loa Loa (eye worm) calpain 5 0.0059 0.0057 0.0716
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0067 0.0267
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0045 0.0173
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0029 0.0341
Onchocerca volvulus 0.0036 0.0018 0.0299
Schistosoma mansoni hypothetical protein 0.0041 0.0026 0.0098
Leishmania major DNA damage repair protein, putative 0.0036 0.0018 0.0214
Echinococcus granulosus tar DNA binding protein 0.0065 0.0067 0.0277
Echinococcus granulosus pyruvate kinase 0.0053 0.0046 0.0191
Loa Loa (eye worm) hypothetical protein 0.0028 0.0004 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0045 0.0557
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0004 0.0004
Brugia malayi hypothetical protein 0.0074 0.0084 0.1021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0059 0.0057 0.0674
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0006 0.0025
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0091 0.0091
Echinococcus granulosus importin subunit beta 1 0.0028 0.0004 0.0017
Echinococcus multilocularis hypothetical protein 0.0059 0.0057 0.0057
Plasmodium vivax DNA repair protein REV1, putative 0.0036 0.0018 0.11
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0029 0.0341
Brugia malayi Importin beta-1 subunit 0.0028 0.0004 0.002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0087 0.3277
Trypanosoma cruzi kinesin, putative 0.0059 0.0057 0.0674
Schistosoma mansoni Mername-AA248 (C02 family) 0.0059 0.0057 0.0226
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Trypanosoma brucei unspecified product 0.0081 0.0095 0.1074
Mycobacterium ulcerans pyruvate kinase 0.0103 0.0133 0.5378
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Echinococcus multilocularis survival motor neuron protein 1 0.049 0.0801 0.0801
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Schistosoma mansoni survival motor neuron protein 0.01 0.0128 0.0516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0031
Chlamydia trachomatis pyruvate kinase 0.0103 0.0133 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0158 0.1855
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0016 0.02
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0059 0.0057 0.0674
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0045 0.0183
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0018 0.048
Onchocerca volvulus 0.0032 0.0011 0.0188
Echinococcus granulosus calpain 0.0059 0.0057 0.0236
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0059 0.0057 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Schistosoma mansoni coup transcription factor 0.0052 0.0045 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0045 0.0527
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.0479 0.5612
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0018 0.048
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0018 0.1372
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0067 0.084
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0087 0.5
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0087 0.2317
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0091 0.0374
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0036 0.015
Echinococcus granulosus pyruvate kinase 0.0053 0.0046 0.0191
Echinococcus multilocularis cpg binding protein 0.0098 0.0125 0.0125
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0045 0.0183
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0014 0.0047
Loa Loa (eye worm) hypothetical protein 0.0139 0.0196 0.245
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0029 0.0341
Brugia malayi ecdysteroid receptor 0.0052 0.0045 0.0527
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.007 0.007
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.0363 0.4536
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0084 0.0084
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0087 0.2317
Entamoeba histolytica protein kinase, putative 0.0059 0.0057 0.2808
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0034 0.0429
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0036 0.014
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0036 0.0036
Schistosoma mansoni lamin 0.0085 0.0103 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Echinococcus granulosus dna polymerase kappa 0.0117 0.0158 0.065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0228
Plasmodium vivax pyruvate kinase, putative 0.0103 0.0133 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0059 0.0057 0.0674
Trichomonas vaginalis pyruvate kinase, putative 0.0103 0.0133 0.3524
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0087 0.1027
Onchocerca volvulus 0.01 0.0128 0.2099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0045 0.0183
Trypanosoma brucei pyruvate kinase 1 0.0103 0.0133 0.1521
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0018 0.1101
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0048 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0045 0.0173
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0018 0.0167
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0018 0.048
Brugia malayi nuclear hormone receptor 0.0052 0.0045 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0158 0.1816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0045 0.0557
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.0275 0.0275
Schistosoma mansoni zinc finger protein 0.003 0.0008 0.0022
Schistosoma mansoni calpain C (C02 family) 0.0059 0.0057 0.0226
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0048 0.0048
Toxoplasma gondii pyruvate kinase PyKII 0.0053 0.0046 0.1668
Schistosoma mansoni importin beta-1 0.0028 0.0004 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0018 0.0214
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0045 0.0183
Schistosoma mansoni bromodomain containing protein 0.0131 0.0182 0.0737
Loa Loa (eye worm) hypothetical protein 0.0248 0.0384 0.4792
Trypanosoma cruzi ISWI complex protein 0.003 0.0008 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0117 0.0158 0.1948
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0087 0.0984
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0091 0.0091
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0238 0.2952
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0519 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0557
Brugia malayi intermediate filament protein 0.0085 0.0103 0.1257
Onchocerca volvulus Huntingtin homolog 0.0378 0.0609 1
Leishmania major kinesin, putative 0.0059 0.0057 0.0674
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0059 0.0057 0.0674

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Blocking of lactate production in primary human osteoblasts at 100 uM after 1 hr by ELISA ChEMBL. 17088489
Activity (functional) 0 Blocking of lactate production in MG63 cells at 100 uM after 1 hr by ELISA ChEMBL. 17088489
Activity (functional) 0 Inhibition of lactate production in primary human osteoblasts after 48 hrs by ELISA ChEMBL. 17088489
Activity (functional) 0 Inhibition of lactate production in MG63 cells after 48 hrs by ELISA by ELISA ChEMBL. 17088489
Inhibition (binding) = 75 % Inhibition of PFKFB3-mediated glycolysis in human MDA-MB-231 cells assessed as extracellular acidification rate at 100 uM after 2 hrs ChEMBL. 24398380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from structural similarity (ECO:0000027) Leishmania major 23720  
Annotator: aaronjr@u.washington.edu Comment: Drug: 26305-03-3. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; References: 17028008
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 23720  
Annotator: aaronjr@u.washington.edu Comment: Drug: 26305-03-3. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; References: 17028008

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

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