Detailed information for compound 44629

Basic information

Technical information
  • TDR Targets ID: 44629
  • Name: 4-(3-methyl-2,6-dioxo-1-propyl-7H-purin-8-yl) benzonitrile
  • MW: 309.323 | Formula: C16H15N5O2
  • H donors: 1 H acceptors: 4 LogP: 1.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(=O)c2nc([nH]c2n(c1=O)C)c1ccc(cc1)C#N
  • InChi: 1S/C16H15N5O2/c1-3-8-21-15(22)12-14(20(2)16(21)23)19-13(18-12)11-6-4-10(9-17)5-7-11/h4-7H,3,8H2,1-2H3,(H,18,19)
  • InChiKey: DWDAAVQEWYIRTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-methyl-2,6-dioxo-1-propyl-7H-purin-8-yl)benzenecarbonitrile
  • 4-(2,6-diketo-3-methyl-1-propyl-7H-purin-8-yl)benzonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 356 aa 23.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 22.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2 receptor   410 aa 346 aa 28.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2 receptor   410 aa 399 aa 28.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 23.1 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 337 aa 23.1 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2 receptor   410 aa 366 aa 25.4 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 315 aa 21.6 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2 receptor   410 aa 340 aa 27.9 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0334 0.1372
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0009 0.0177
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0334 0.046
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0016 0.0516
Toxoplasma gondii patched family protein 0.0012 0.0006 0.0014
Leishmania major telomerase reverse transcriptase, putative 0.1521 0.272 1
Schistosoma mansoni topbp1 0.001 0.0002 0.0008
Schistosoma mansoni DNA ligase IV 0.001 0.0002 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.02 0.0822
Brugia malayi Patched protein homolog 1 0.0012 0.0006 0.0008
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0016 0.0701
Leishmania major cytochrome p450-like protein 0.0017 0.0016 0.0024
Echinococcus multilocularis protein dispatched 1 0.0095 0.0156 0.0544
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0036 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0097 0.1182
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0128 0.0465
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0097 0.04
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0022 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0069 0.0095
Trichomonas vaginalis DNA polymerase I, putative 0.0033 0.0043 0.3104
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0016 0.0751
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0009 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0069 0.0095
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0156 0.0215
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0033 0.0043 0.1239
Loa Loa (eye worm) hypothetical protein 0.0467 0.0825 1
Leishmania major GTP-binding protein, putative 0.0021 0.0022 0.0048
Brugia malayi Cytochrome P450 family protein 0.0055 0.0083 0.0115
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0009 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0036 0.0125
Brugia malayi cytochrome P450 0.0017 0.0016 0.0022
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0016 0.0701
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0135 0.0553
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0016 0.0701
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0069 0.3369
Onchocerca volvulus 0.0014 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) histone methyltransferase 0.0009 0 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0083 0.1011
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0271
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.008 0.0129 0.053
Brugia malayi protein C24B5.3 0.0012 0.0006 0.0008
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0016 0.0701
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.02 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0036 0.0125
Echinococcus multilocularis microtubule associated protein 2 0.1364 0.2438 0.8502
Brugia malayi hypothetical protein 0.0071 0.0112 0.0155
Echinococcus granulosus cpg binding protein 0.003 0.0038 0.0157
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0009 0.0032
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0022 0.0075
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.008 0.0128 0.0465
Schistosoma mansoni hypothetical protein 0.0305 0.0534 0.2189
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi Muscleblind-like protein 0.0295 0.0516 0.071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0044 0.1965
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0009 0.0027
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0000029718
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0097 0.04
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0009 0.0027
Schistosoma mansoni ran 0.0021 0.0022 0.0092
Chlamydia trachomatis DNA polymerase I 0.0113 0.0187 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0009 0.0013
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0000074441
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0009 0.0027
Brugia malayi DKFZp564C0469 protein 0.001 0.0002 0.0003
Loa Loa (eye worm) patched family protein 0.0012 0.0006 0.0069
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0128 0.044
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0097 0.034
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1521 0.272 1
Onchocerca volvulus 0.0012 0.0006 0.0006
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0009 0.0368
Echinococcus multilocularis protein patched 0.0083 0.0135 0.047
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0009 0.0368
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0047 0.0168
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0016 0.0701
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0016 0.0516
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0031 0.038
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0016 0.0701
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0031
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.0825 0.2878
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.008 0.0128 0.0465
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0016 0.0701
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.008 0.0128 0.6302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.02 0.0699
Onchocerca volvulus Protein patched homolog 0.0012 0.0006 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0 0.0001
Schistosoma mansoni cpg binding protein 0.003 0.0038 0.0157
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0097 0.1182
Plasmodium vivax patched family protein, putative 0.0012 0.0006 0.0014
Plasmodium falciparum telomerase reverse transcriptase 0.1521 0.272 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0069 0.3369
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0009 0.0551
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0009 0.0368
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0523
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0009 0.0368
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0016 0.0701
Schistosoma mansoni survival motor neuron protein 0.0095 0.0156 0.064
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0009 0.0027
Brugia malayi Cytochrome P450 family protein 0.0026 0.0031 0.0043
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0009 0.0027
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0036 0.0125
Loa Loa (eye worm) cytochrome P450 0.0017 0.0016 0.0192
Onchocerca volvulus 0.0012 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0016 0.0701
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1521 0.272 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0036 0.0125
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0069 0.3237
Onchocerca volvulus 0.0014 0.0009 0.0009
Echinococcus multilocularis 0.0017 0.0016 0.0055
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.0534 0.6467
Brugia malayi CHE-14 protein 0.0083 0.0135 0.0185
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0575
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0016 0.0051
Schistosoma mansoni DNA polymerase I 0.0033 0.0043 0.0177
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0069 0.3369
Schistosoma mansoni hypothetical protein 0.0095 0.0156 0.064
Plasmodium falciparum importin beta, putative 0.0029 0.0036 0.0125
Giardia lamblia Telomerase catalytic subunit 0.1521 0.272 1
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0016 0.0065
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.034 0.1394
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.0825 0.3385
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0113 0.0187 1
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0135 0.0553
Brugia malayi hypothetical protein 0.001 0.0002 0.0003
Loa Loa (eye worm) RNA binding protein 0.0063 0.0097 0.1182
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0069 0.0095
Onchocerca volvulus 0.0012 0.0006 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.02 0.0822
Loa Loa (eye worm) patched family protein 0.0012 0.0006 0.0069
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0016 0.0024
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0026 0.1828
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0009 0.0112
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0069 0.3369
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0069 0.3369
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0075
Onchocerca volvulus 0.0028 0.0035 0.0035
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0016 0.0516
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0016 0.0701
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0016 0.0516
Brugia malayi hypothetical protein 0.0012 0.0006 0.0008
Echinococcus multilocularis cpg binding protein 0.003 0.0038 0.0133
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0033 0.0043 0.0152
Entamoeba histolytica hypothetical protein 0.0071 0.0112 0.3322
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Brugia malayi TAR-binding protein 0.0063 0.0097 0.0134
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0128 0.0465
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0016 0.0701
Loa Loa (eye worm) hypothetical protein 0.0083 0.0135 0.1632
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0097 0.04
Brugia malayi RNA, U transporter 1 0.0081 0.0131 0.018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.02 0.0705
Mycobacterium ulcerans DNA polymerase I 0.0113 0.0187 0.933
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0016 0.0516
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0031 0.0108
Echinococcus granulosus expressed conserved protein 0.0183 0.0313 0.1285
Echinococcus multilocularis expressed conserved protein 0.0183 0.0313 0.1093
Entamoeba histolytica hypothetical protein 0.0071 0.0112 0.3322
Entamoeba histolytica hypothetical protein 0.0023 0.0026 0.073
Brugia malayi Cytochrome P450 family protein 0.0017 0.0016 0.0022
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0395
Brugia malayi CXXC zinc finger family protein 0.0028 0.0035 0.0049
Echinococcus multilocularis muscleblind protein 0.0295 0.0516 0.1798
Schistosoma mansoni ran 0.0021 0.0022 0.0092
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0016 0.0701
Onchocerca volvulus 0.0012 0.0006 0.0006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0135 0.1632
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0016 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Brugia malayi hypothetical protein 0.0012 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.008 0.0129 0.053
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0016 0.0516
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0097 0.04
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0016 0.0701
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0075
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0069 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium ulcerans hypothetical protein 0.0047 0.0069 0.3369
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0113 0.0187 0.9317
Echinococcus granulosus nibrin 0.001 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.008 0.0129 0.053
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0016 0.0516
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0009 0.0395
Echinococcus granulosus muscleblind protein 0.0295 0.0516 0.2115
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0009 0.0177
Leishmania major importin beta-1 subunit, putative 0.0023 0.0026 0.0063
Loa Loa (eye worm) patched family protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0834
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0575
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0047 0.2142
Schistosoma mansoni hypothetical protein 0.0403 0.0709 0.2908
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0009 0.0177
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0016 0.0701
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0575
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.00000036355
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0047 0.246
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0834
Plasmodium vivax plastid replication-repair enzyme, putative 0.0033 0.0043 0.0152
Brugia malayi DNA polymerase I family protein 0.0033 0.0043 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0016 0.0516
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0016 0.0516
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0016 0.0516
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0035 0.0429
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0024
Brugia malayi Importin beta-1 subunit 0.0029 0.0036 0.0049
Schistosoma mansoni hypothetical protein 0.008 0.0129 0.053
Brugia malayi Telomerase reverse transcriptase 0.4047 0.7264 1
Mycobacterium ulcerans 5'-3' exonuclease 0.008 0.0128 0.6374
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0022 0.0075
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0009 0.0368
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1602 0.2867 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) patched family protein 0.0012 0.0006 0.0069
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0033 0.0043 0.0125
Brugia malayi Patched related family protein 4 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0047 0.0168
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0009 0.0177
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Onchocerca volvulus 0.0012 0.0006 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0112 0.0461
Toxoplasma gondii patched family protein 0.0012 0.0006 0.0014
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0135 0.047
Trichomonas vaginalis ran, putative 0.0021 0.0022 0.1538
Toxoplasma gondii hypothetical protein 0.0012 0.0006 0.0014
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0069 0.201
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0016 0.0051
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0016 0.0051
Loa Loa (eye worm) hypothetical protein 0.0295 0.0516 0.6248
Echinococcus granulosus microtubule associated protein 2 0.1364 0.2438 1
Brugia malayi Patched related family protein 10 0.0012 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.0071 0.0112 0.3322
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Treponema pallidum DNA polymerase I (polA) 0.0113 0.0187 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0069 0.201
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.02 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0009 0.0368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Echinococcus granulosus snurportin 1 0.0305 0.0534 0.2189
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0013
Brugia malayi hypothetical protein 0.0012 0.0006 0.0008
Brugia malayi hypothetical protein 0.0012 0.0006 0.0008
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0002 0.0003
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0075
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0016 0.0701
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0033 0.0043 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Echinococcus granulosus replication factor c subunit 1 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0024
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0009 0.0027
Echinococcus granulosus importin subunit beta 1 0.0029 0.0036 0.0147
Schistosoma mansoni microtubule-associated protein tau 0.1364 0.2438 1
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0575
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0834
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0016 0.0516
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0069 0.201
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0128 0.0465
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0013
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0033 0.0043 0.0152
Schistosoma mansoni importin beta-1 0.0029 0.0036 0.0147
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0009 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0069 0.3369
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0033 0.0043 0.0152
Schistosoma mansoni cpg binding protein 0.0028 0.0035 0.0145
Toxoplasma gondii patched family protein 0.0012 0.0006 0.0014
Onchocerca volvulus 0.0012 0.0006 0.0006
Mycobacterium leprae putative cytochrome p450 0.0017 0.0016 0.0751
Echinococcus granulosus twinkle protein mitochondrial 0.0024 0.0028 0.0114
Leishmania major cytochrome p450-like protein 0.0026 0.0031 0.0082
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0002 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0016 0.0516
Echinococcus multilocularis twinkle protein, mitochondrial 0.0024 0.0028 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0016 0.0516
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0026 0.1828
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Schistosoma mansoni cytochrome P450 0.0017 0.0016 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0092 0.0379
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0009 0.0368
Loa Loa (eye worm) twinkle helicase 0.0024 0.0028 0.0337
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0069 0.3369
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0135 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0575
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.02 0.0822
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0009 0.0027
Loa Loa (eye worm) patched family protein 0.0012 0.0006 0.0069
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0009 0.0368
Onchocerca volvulus 0.0014 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0016 0.0516
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.02 0.073
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0016 0.0516
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0114
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0016 0.0516
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Toxoplasma gondii RNA-directed DNA polymerase 0.1521 0.272 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0009 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0009 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0044 0.1965
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Onchocerca volvulus 0.001 0.0002 0.0002
Echinococcus granulosus tar DNA binding protein 0.0063 0.0097 0.04
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0009 0.0395
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0000074441
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0334 0.1167
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0016 0.0701
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0016 0.0051
Echinococcus multilocularis nibrin 0.001 0.0002 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0112 0.0392
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0009 0.0038
Schistosoma mansoni patched 1 0.0083 0.0135 0.0553
Echinococcus multilocularis Niemann Pick C1 protein 0.0278 0.0485 0.169
Loa Loa (eye worm) hypothetical protein 0.0102 0.0168 0.2042
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0016 0.0516
Onchocerca volvulus 0.0014 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0436
Onchocerca volvulus Protein patched homolog 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0 0.0001
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0113 0.0187 1
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0031 0.038
Echinococcus granulosus dnaJ subfamily B 0.0403 0.0709 0.2908
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0009 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0069 0.3237
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0022 0.0078
Toxoplasma gondii helicase, putative 0.0033 0.0043 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi protein C24B5.3 0.0012 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0065
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0024 0.0028 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0031 0.0108
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0069 0.022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0026 0.1828
Brugia malayi Myosin head containing protein 0.0012 0.0006 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0097 0.0134
Plasmodium falciparum plastid replication-repair enzyme 0.0033 0.0043 0.0152
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0009 0.0551
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0024
Brugia malayi topoisomerase 0.001 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi Patched related family protein 12 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0112
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0026 0.0089
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0069 0.022
Echinococcus multilocularis muscleblind protein 1 0.0295 0.0516 0.1798
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0016 0.0516
Echinococcus granulosus Niemann Pick C1 protein 0.0278 0.0485 0.1988
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0016 0.0701
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Brugia malayi Patched family protein 0.0012 0.0006 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0081 0.029
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0016 0.0701
Schistosoma mansoni hypothetical protein 0.0071 0.0112 0.0461
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0002 0.0000074441
Schistosoma mansoni topbp1 0.001 0.0002 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Schistosoma mansoni cpg binding protein 0.003 0.0038 0.0157
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0002 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0044 0.1965
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0033 0.0043 0.0152
Loa Loa (eye worm) oxidoreductase 0.0014 0.0009 0.0112
Onchocerca volvulus 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0195 0.0334 0.4054
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0016 0.0516
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.02 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0009 0.0038
Entamoeba histolytica hypothetical protein 0.0071 0.0112 0.3322
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0016 0.0701
Brugia malayi Cytochrome P450 family protein 0.0026 0.0031 0.0043
Onchocerca volvulus 0.0095 0.0156 0.0156
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0031 0.1483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0044 0.1965
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0112 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0069 0.3611
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0009 0.0027
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0039 0.0055 0.0195
Trypanosoma brucei telomerase reverse transcriptase 0.1521 0.272 1
Leishmania major cytochrome p450-like protein 0.0017 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi hypothetical protein 0.001 0.0002 0.0003
Plasmodium vivax telomerase reverse transcriptase, putative 0.1521 0.272 1
Toxoplasma gondii patched family protein 0.0012 0.0006 0.0014
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0009 0.022
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0031 0.0108
Onchocerca volvulus 0.0047 0.0069 0.0069
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0009 0.0177
Loa Loa (eye worm) hypothetical protein 0.0295 0.0516 0.6248
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0097 0.04
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0016 0.0516
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.02 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0334 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0009 0.0013
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0000044118 0.0000060732
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.0709 0.2473
Brugia malayi RNA binding protein 0.0063 0.0097 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0069
Brugia malayi hypothetical protein 0.0467 0.0825 0.1136
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0006 0.0014
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0075
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0069 0.3611
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0047 0.2295
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0031 0.038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0112
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0016 0.0701
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0024
Entamoeba histolytica Ran family GTPase 0.0021 0.0022 0.0614
Echinococcus multilocularis snurportin 1 0.0305 0.0534 0.1861

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.95 nM Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]-cyclohexyladenosine (CHA). ChEMBL. 2016719
Ki (binding) = 5.95 nM Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]-cyclohexyladenosine (CHA). ChEMBL. 2016719
Ki (binding) = 446 nM Binding affinity against adenosine A2 receptor in rat striatum by the displacement of [3H]-N-ethyladenosine-5''-uronamide(NECA). ChEMBL. 2016719
Ki (binding) = 446 nM Binding affinity against adenosine A2 receptor in rat striatum by the displacement of [3H]-N-ethyladenosine-5''-uronamide(NECA). ChEMBL. 2016719
Ratio (binding) = 75 Ratio of the binding affinities of A2 /A1 receptor ChEMBL. 2016719
Ratio (binding) = 75 Ratio of the binding affinities of A2 /A1 receptor ChEMBL. 2016719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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