Detailed information for compound 565910

Basic information

Technical information
  • TDR Targets ID: 565910
  • Name: (7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acet yl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[ 4.2.0]oct-2-ene-2-carboxylic acid
  • MW: 363.388 | Formula: C16H17N3O5S
  • H donors: 4 H acceptors: 5 LogP: -2.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](c1ccc(cc1)O)N)N[C@@H]1C(=O)N2C1SCC(=C2C(=O)O)C
  • InChi: 1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15?/m1/s1
  • InChiKey: BOEGTKLJZSQCCD-MHSSMOFYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (7R)-7-[[(2R)-2-azanyl-2-(4-hydroxyphenyl)ethanoyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-keto-3-methyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefadroxil
  • (7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)ethanoyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Prestwick_919

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain containing protein 0.0065 0.0262 0.0362
Mycobacterium ulcerans beta-lactamase 0.0289 0.1485 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0129
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0213 0.0294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0159 0.0689
Echinococcus granulosus neutral alpha glucosidase AB 0.015 0.0725 0.1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0677 0.3599 0.5559
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0005 0.003
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0031 0.003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0677 0.3599 0.5559
Mycobacterium leprae conserved hypothetical protein 0.0289 0.1485 1
Schistosoma mansoni chromobox protein 0.0074 0.0308 0.0425
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0097 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0213 0.1433
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0213 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0031
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0031 0.0681
Echinococcus granulosus caspase 2 0.006 0.0234 0.0323
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0127
Schistosoma mansoni smad1 5 8 and 0.0035 0.0097 0.0134
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0287 0.1474 0.2277
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0001 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0093 0.0626
Echinococcus multilocularis microtubule associated protein 2 0.1345 0.7248 0.8071
Schistosoma mansoni hypothetical protein 0.0098 0.0443 0.0611
Brugia malayi MH1 domain containing protein 0.0035 0.0097 0.015
Schistosoma mansoni tyrosine kinase 0.1203 0.6473 0.8931
Entamoeba histolytica hypothetical protein 0.0023 0.0031 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0032
Loa Loa (eye worm) inositol-1 0.0036 0.0102 0.0158
Schistosoma mansoni intermediate filament proteins 0.0033 0.0083 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.002 0.003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0097 0.0134
Schistosoma mansoni tyrosine kinase 0.064 0.3397 0.4687
Brugia malayi steroid hormone receptor 0.0021 0.002 0.003
Schistosoma mansoni nuclear hormone receptor 0.0021 0.002 0.0027
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0686
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0056 0.0211 0.1128
Plasmodium vivax hypothetical protein, conserved 0.0289 0.1485 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0203 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0194 0.0268
Loa Loa (eye worm) TK/INSR protein kinase 0.0385 0.2004 0.3096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0033 0.0219
Schistosoma mansoni tyrosine kinase 0.0647 0.3434 0.4738
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.035 0.0541
Schistosoma mansoni ran 0.0023 0.0033 0.0045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0098 0.0109
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.002 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.114 0.114
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0443 0.0684
Plasmodium falciparum glutathione reductase 0.0034 0.0093 0.208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0592 0.3862
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0213 0.1433
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.0447 0.0447
Trypanosoma brucei glucosidase, putative 0.015 0.0725 0.488
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0228
Loa Loa (eye worm) hypothetical protein 0.0289 0.1485 0.2295
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0102 0.2178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.002 0.003
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0005 0.0031
Schistosoma mansoni hypothetical protein 0.0836 0.4469 0.6165
Leishmania major importin beta-1 subunit, putative 0.0026 0.0046 0.0306
Onchocerca volvulus 0.0033 0.0083 0.0314
Plasmodium falciparum importin beta, putative 0.0032 0.0078 0.1748
Plasmodium falciparum glutathione reductase 0.0099 0.0447 1
Brugia malayi Heterochromatin protein 1 0.0074 0.0308 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.002 0.003
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0308 0.1661
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0647 0.3434 0.4738
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.175 0.2703
Brugia malayi hypothetical protein 0.0038 0.0113 0.0175
Echinococcus multilocularis musashi 0.0033 0.0083 0.0093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.114 0.114
Brugia malayi nuclear receptor NHR-88 0.0021 0.002 0.003
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0023 0.0151
Toxoplasma gondii hypothetical protein 0.0029 0.0062 0.0414
Schistosoma mansoni cpg binding protein 0.0064 0.0254 0.0351
Echinococcus granulosus tar DNA binding protein 0.0136 0.0647 0.0892
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0647 0.0999
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0042 0.0279
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0847 0.0846
Brugia malayi Latrophilin receptor protein 2 0.0085 0.0368 0.0568
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.002 0.003
Schistosoma mansoni hypothetical protein 0.0085 0.0368 0.0507
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0046 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.1474 0.2034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.006 0.0234 0.0362
Brugia malayi nuclear hormone receptor 0.0021 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0289 0.1485 0.2295
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0056 0.0211 0.1418
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0005 0.003
Echinococcus multilocularis neutral alpha glucosidase AB 0.015 0.0725 0.0807
Brugia malayi beta-lactamase 0.0289 0.1485 0.2295
Mycobacterium ulcerans hypothetical protein 0.0289 0.1485 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0031 0.0205
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.002 0.0022
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.035 0.0483
Echinococcus multilocularis neuropeptide s receptor 0.0914 0.4897 0.5453
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0211 0.1128
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.033 0.7374
Echinococcus multilocularis muscleblind protein 0.0294 0.1509 0.1681
Toxoplasma gondii exonuclease III APE 0.0056 0.0213 0.1433
Onchocerca volvulus 0.006 0.0234 0.1061
Loa Loa (eye worm) hypothetical protein 0.0294 0.1509 0.2332
Trichomonas vaginalis D-aminoacylase, putative 0.0289 0.1485 0.8104
Echinococcus multilocularis lysosomal alpha glucosidase 0.0677 0.3599 0.4007
Loa Loa (eye worm) hypothetical protein 0.0483 0.254 0.3923
Trichomonas vaginalis D-aminoacylase, putative 0.0289 0.1485 0.8104
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0203 0.1182
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0592 0.0817
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0213 0.1433
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0289 0.1485 0.1485
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0243 0.0271
Loa Loa (eye worm) hypothetical protein 0.0289 0.1485 0.2295
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0359 0.2255
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0097 0.0134
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.015 0.0725 0.3943
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0005 0.0003
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0289 0.1485 0.2295
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0033 0.0036
Brugia malayi MH2 domain containing protein 0.0035 0.0097 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0065 0.0332
Trichomonas vaginalis alpha-glucosidase, putative 0.015 0.0725 0.3943
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.114 0.114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0847 0.5608
Plasmodium vivax importin-beta 2, putative 0.0032 0.0078 0.0526
Brugia malayi CXXC zinc finger family protein 0.0059 0.0226 0.0349
Entamoeba histolytica hypothetical protein 0.0038 0.0113 0.0596
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0017
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0202 0.0278
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0159 0.0177
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.0124
Trichomonas vaginalis sucrase-isomaltase, putative 0.015 0.0725 0.3943
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0062 0.1376
Echinococcus granulosus GPCR family 2 0.0085 0.0368 0.0507
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.002 0.0027
Brugia malayi Bromodomain containing protein 0.0038 0.011 0.017
Schistosoma mansoni smad1 5 8 and 0.0035 0.0097 0.0134
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0194 0.0216
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0033 0.0219
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0359 0.0399
Toxoplasma gondii ABC1 family protein 0.0289 0.1485 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0096 0.0106
Echinococcus granulosus Solute carrier family 22 5 0.125 0.6728 0.9283
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0005 0.0031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Loa Loa (eye worm) hypothetical protein 0.0032 0.0078 0.0121
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0081 0.0081
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0005 0.003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0044 0.0216
Echinococcus multilocularis lamin 0.0033 0.0083 0.0093
Echinococcus granulosus neuropeptide s receptor 0.0914 0.4897 0.6756
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.1278 0.1278
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0027
Schistosoma mansoni ran 0.0023 0.0033 0.0045
Loa Loa (eye worm) glutathione reductase 0.0099 0.0447 0.069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0004 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.1474 0.1641
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0093 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0592 0.0817
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0093 0.0484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.0368 0.0507
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.033 0.2218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0203
Loa Loa (eye worm) hypothetical protein 0.0078 0.033 0.0509
Brugia malayi Thioredoxin reductase 0.0099 0.0447 0.069
Brugia malayi Furin-like cysteine rich region family protein 0.1203 0.6473 1
Echinococcus granulosus lamin dm0 0.0033 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.006 0.0234 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.003
Echinococcus granulosus epidermal growth factor receptor 0.0647 0.3434 0.4738
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.002 0.0027
Brugia malayi TAR-binding protein 0.0136 0.0647 0.0999
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.003
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0102 0.0534
Loa Loa (eye worm) hypothetical protein 0.0294 0.1509 0.2332
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0093 0.0626
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0044 0.0216
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1663 0.898 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0131 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.002 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0044 0.0216
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0203 0.0279
Echinococcus multilocularis insulin receptor 0.0385 0.2004 0.2232
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0093 0.1905
Echinococcus multilocularis lysosomal alpha glucosidase 0.0677 0.3599 0.4007
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0031 0.0205
Schistosoma mansoni chromobox protein 0.0074 0.0308 0.0425
Mycobacterium tuberculosis Probable lipase LipE 0.0289 0.1485 0.1485
Loa Loa (eye worm) hypothetical protein 0.0083 0.0359 0.0554
Echinococcus multilocularis caspase 2 0.006 0.0234 0.0261
Brugia malayi mbt repeat family protein 0.0046 0.0159 0.0245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.0368 0.041
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0159 0.0219
Mycobacterium tuberculosis Probable reductase 0.0226 0.114 0.114
Echinococcus granulosus epidermal growth factor receptor 0.1203 0.6473 0.8931
Echinococcus granulosus dnaJ subfamily B 0.0836 0.4469 0.6165
Trichomonas vaginalis penicillin-binding protein, putative 0.0289 0.1485 0.8104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0289 0.1485 0.2049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.002 0.0027
Schistosoma mansoni smad 0.0035 0.0097 0.0134
Brugia malayi Glycosyl hydrolases family 31 protein 0.015 0.0725 0.112
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0031 0.0205
Schistosoma mansoni hypothetical protein 0.0294 0.1509 0.2082
Loa Loa (eye worm) hypothetical protein 0.0069 0.0284 0.0438
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0093 0.0626
Loa Loa (eye worm) RNA binding protein 0.0136 0.0647 0.0999
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.254 0.2828
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0284 0.0391
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.0447 0.3008
Echinococcus multilocularis GPCR, family 2 0.0085 0.0368 0.041
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0005 0.003
Echinococcus multilocularis zinc finger protein 0.0023 0.0028 0.0032
Mycobacterium tuberculosis Probable hydrolase 0.0289 0.1485 0.1485
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0213 0.5558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.1474 0.2034
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0159 0.0246
Onchocerca volvulus 0.0289 0.1485 0.7249
Loa Loa (eye worm) transcription factor SMAD2 0.0515 0.2717 0.4198
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0093 0.0626
Loa Loa (eye worm) hypothetical protein 0.0054 0.0202 0.0312
Schistosoma mansoni hypothetical protein 0.0085 0.0368 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0725 0.488
Onchocerca volvulus 0.0032 0.0082 0.031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.015 0.0725 0.3943
Trypanosoma cruzi hypothetical protein, conserved 0.0289 0.1485 1
Echinococcus granulosus muscleblind protein 0.0294 0.1509 0.2082
Brugia malayi hypothetical protein 0.0483 0.254 0.3923
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0359 0.2414
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0004 0.0004
Trypanosoma brucei trypanothione reductase 0.0099 0.0447 0.3008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Echinococcus granulosus apoptotic protease activating factor 1 0.006 0.0234 0.0323
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.0967 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.0289 0.1485 1
Schistosoma mansoni hypothetical protein 0.0716 0.3812 0.5259
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0093 0.0103
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.035 0.0483
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0078 0.0526
Echinococcus multilocularis dnaJ subfamily B 0.0836 0.4469 0.4976
Echinococcus multilocularis smad 0.0035 0.0097 0.0108
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0359 0.0495
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0385 0.2004 0.2232
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0289 0.1485 0.2295
Trichomonas vaginalis penicillin-binding protein, putative 0.0289 0.1485 0.8104
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0042 0.0064
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0213 0.1012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0022
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0284 0.1908
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0194 0.0268
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0213 0.114
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0359 0.0495
Echinococcus multilocularis chromobox protein 1 0.0074 0.0308 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0102 0.0491
Brugia malayi Muscleblind-like protein 0.0294 0.1509 0.2331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0031
Echinococcus granulosus microtubule associated protein 2 0.1345 0.7248 1
Schistosoma mansoni tyrosine kinase 0.0385 0.2004 0.2765
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.002 0.0027
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0194 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0102 0.0534
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0062 0.0172
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0258 0.0399
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0006
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0686
Echinococcus granulosus neuropeptide receptor A26 0.0914 0.4897 0.6756
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.0368 0.0568
Trichomonas vaginalis maltase-glucoamylase, putative 0.0056 0.0211 0.1128
Trichomonas vaginalis maltase-glucoamylase, putative 0.015 0.0725 0.3943
Loa Loa (eye worm) POT family protein 0.0099 0.0443 0.0685
Mycobacterium ulcerans esterase/lipase LipP 0.0289 0.1485 1
Brugia malayi beta-lactamase family protein 0.0289 0.1485 0.2295
Mycobacterium tuberculosis Probable esterase LipL 0.0289 0.1485 0.1485
Loa Loa (eye worm) hypothetical protein 0.0289 0.1485 0.2295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.002 0.0027
Brugia malayi glutathione reductase 0.0099 0.0447 0.069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0093 0.0626
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0213 0.114
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0042 0.0279
Onchocerca volvulus 0.0391 0.2042 1
Schistosoma mansoni tyrosine kinase 0.064 0.3397 0.4687
Brugia malayi Inositol-1 0.0036 0.0102 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Onchocerca volvulus 0.0046 0.0159 0.0689
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0005 0.003
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0194 0.03
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.002 0.0027
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0081 0.035
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0131 0.0693
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0042 0.0046
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0078 0.0526
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0044 0.0216
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0203
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0062 0.0213
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0014 0.0021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0592 0.066
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0031 0.0205
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0284 0.0438
Brugia malayi Importin beta-1 subunit 0.0032 0.0078 0.0121
Brugia malayi POT family protein 0.0099 0.0443 0.0684
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0062 0.0414
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0159 0.0219
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0159 0.0219
Leishmania major GTP-binding protein, putative 0.0023 0.0033 0.0219
Brugia malayi Glycosyl hydrolases family 31 protein 0.0056 0.0211 0.0325
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0211 0.1128
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0016 0.0025
Brugia malayi mbt repeat family protein 0.0046 0.0159 0.0245
Brugia malayi Bromodomain containing protein 0.0077 0.0325 0.0502
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0308 0.0476
Echinococcus granulosus FTZ F1 alpha 0.0021 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0716 0.3812 0.5259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0018
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0252 0.1278 0.1278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.002 0.0027
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0093 0.043
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0447 0.0616
Mycobacterium leprae Probable lipase LipE 0.0289 0.1485 1
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.0447 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0031
Echinococcus granulosus importin subunit beta 1 0.0032 0.0078 0.0108
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0033 0.005
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0159 0.0219
Brugia malayi hypothetical protein 0.006 0.0234 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0359 0.2414
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0211 0.1128
Brugia malayi latrophilin 2 splice variant baaae 0.0183 0.0905 0.1397
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0647 0.072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.002 0.0022
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0005 0.003
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0044 0.0061
Schistosoma mansoni hypothetical protein 0.006 0.0234 0.0323
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0211 0.1128
Brugia malayi MH2 domain containing protein 0.0515 0.2717 0.4197
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0027
Loa Loa (eye worm) TK/EGFR protein kinase 0.1203 0.6473 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0213 0.0329
Loa Loa (eye worm) hypothetical protein 0.0056 0.0211 0.0326
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.1474 0.2034
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0097 0.015
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0046 0.0224
Entamoeba histolytica hypothetical protein 0.0038 0.0113 0.0596
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0078 0.0526
Echinococcus granulosus Smad4 0.0035 0.0097 0.0134
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0005 0.003
Echinococcus granulosus cpg binding protein 0.0064 0.0254 0.0351
Schistosoma mansoni ap endonuclease 0.0056 0.0213 0.0294
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.0246
Schistosoma mansoni survival motor neuron protein 0.0098 0.0443 0.0611
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0031 0.0205
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0044 0.0216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0183 0.0905 0.1398
Echinococcus granulosus chromobox protein 1 0.0074 0.0308 0.0425
Echinococcus multilocularis Smad4 0.0035 0.0097 0.0108
Echinococcus granulosus tumor protein p63 0.0371 0.193 0.2663
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.0967 0.1334
Brugia malayi hypothetical protein 0.0078 0.033 0.0509
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0252 0.1278 0.1278
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0065 0.0332
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0097 0.0108
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0385 0.2004 0.2765
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0234 0.1061
Loa Loa (eye worm) hypothetical protein 0.004 0.0123 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.002 0.003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0093 0.0144
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0005 0.0006
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.035 0.039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.033 0.2218
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0447 0.0497
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0203 0.0202
Echinococcus multilocularis snurportin 1 0.0338 0.175 0.1949
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0097 0.015
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.002 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.114 0.114
Loa Loa (eye worm) beta-lactamase 0.0289 0.1485 0.2295
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0847 0.5608
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0083 0.0129
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0359 0.2414
Echinococcus granulosus lysosomal alpha glucosidase 0.0677 0.3599 0.4965
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.033 0.2218
Brugia malayi Probable ClpP-like protease 0.0083 0.0359 0.0554
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0005 0.003
Brugia malayi MH2 domain containing protein 0.0035 0.0097 0.015
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0033 0.0727
Brugia malayi Calcitonin receptor-like protein seb-1 0.0268 0.1367 0.2112
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0098 0.0135
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1832 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0083 0.0115
Schistosoma mansoni cpg binding protein 0.0064 0.0254 0.0351
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0033 0.0219
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.03
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0102 0.0686
Onchocerca volvulus 0.0081 0.035 0.1635
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0093 0.1905
Entamoeba histolytica hypothetical protein 0.0038 0.0113 0.0596
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0056 0.0211 0.1128
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0096 0.0132
Brugia malayi MH1 domain containing protein 0.0035 0.0097 0.015
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0033 0.005
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0647 0.0999
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0093 0.0484
Schistosoma mansoni alpha glucosidase 0.015 0.0725 0.1
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0097 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0213 0.0237
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 0.2255
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0592 0.0817
Echinococcus multilocularis 0.0372 0.1938 0.2158
Schistosoma mansoni alpha-glucosidase 0.0582 0.3084 0.4256
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0289 0.1485 0.1485
Brugia malayi chromobox protein homolog 3 0.0041 0.0131 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.033 0.7374
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0093 0.0626
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0005 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.001 0.0032
Echinococcus multilocularis muscleblind protein 1 0.0294 0.1509 0.1681
Loa Loa (eye worm) hypothetical protein 0.0289 0.1485 0.2295
Onchocerca volvulus 0.0098 0.0443 0.2092
Loa Loa (eye worm) MH2 domain-containing protein 0.0515 0.2717 0.4198
Trichomonas vaginalis ran, putative 0.0023 0.0033 0.0154
Mycobacterium tuberculosis Conserved protein 0.0289 0.1485 0.1485
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.1474 0.2034
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0284 0.0283
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.0368 0.0507
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0284 0.0391
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0093 0.0484
Trypanosoma brucei hypothetical protein, conserved 0.0289 0.1485 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0243 0.0335
Entamoeba histolytica hypothetical protein 0.0038 0.0113 0.0596
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0148 0.0787
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0005 0.003
Echinococcus granulosus insulin receptor 0.0385 0.2004 0.2765
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0093 0.0626
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0056 0.0211 0.1418
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0044 0.0216
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 0.8025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0027
Onchocerca volvulus 0.0054 0.0202 0.09
Loa Loa (eye worm) nuclear factor I 0.0019 0.0011 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0148 0.0787
Loa Loa (eye worm) hypothetical protein 0.0045 0.0152 0.0235
Onchocerca volvulus 0.0059 0.0226 0.1019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0148 0.0635
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0289 0.1485 0.1485
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0102 0.0113
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.002 0.003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0001 0.0001
Trypanosoma brucei glycosyl hydrolase-like protein 0.0056 0.0211 0.1418
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0102 0.0534
Brugia malayi beta-lactamase family protein 0.0289 0.1485 0.2295
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0102 0.0534
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0592 0.3862
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0289 0.1485 0.2049
Echinococcus multilocularis epidermal growth factor receptor 0.0647 0.3434 0.3824
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0005 0.003
Schistosoma mansoni hypothetical protein 0.0183 0.0905 0.1248
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0284 0.1739
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0043 0.0067
Loa Loa (eye worm) Smad1 0.0035 0.0097 0.015
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.015 0.0725 0.3943
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.015 0.0725 0.488
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.015 0.0725 0.3943
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0005 0.003
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0093 0.0626
Schistosoma mansoni tyrosine kinase 0.0647 0.3434 0.4738
Schistosoma mansoni inositol monophosphatase 0.0036 0.0102 0.0141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0113 0.0126
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.033 0.2218
Mycobacterium tuberculosis Conserved protein 0.0289 0.1485 0.1485
Leishmania major alpha glucosidase II subunit, putative 0.015 0.0725 0.488
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0213 0.0213
Echinococcus granulosus zinc finger protein 0.0023 0.0028 0.0039
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0033 0.0219
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0213 0.4763
Entamoeba histolytica Ran family GTPase 0.0023 0.0033 0.0154
Brugia malayi RNA binding protein 0.0136 0.0647 0.0999
Schistosoma mansoni hypothetical protein 0.0085 0.0368 0.0507
Schistosoma mansoni inositol monophosphatase 0.0036 0.0102 0.0141
Plasmodium vivax glutathione reductase, putative 0.0099 0.0447 0.3008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0056 0.0211 0.1128
Brugia malayi ecdysteroid receptor 0.0021 0.002 0.003
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0234 0.0323
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0033 0.0219
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0093 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0211 0.1128
Echinococcus granulosus lamin 0.0033 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Echinococcus granulosus chromobox protein 1 0.0074 0.0308 0.0425
Mycobacterium ulcerans lipase LipD 0.0289 0.1485 1
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0592 0.3988
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.002 0.003
Schistosoma mansoni cpg binding protein 0.0059 0.0226 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0031
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.033 0.2218
Schistosoma mansoni hypothetical protein 0.0035 0.0096 0.0132
Schistosoma mansoni ap endonuclease 0.0056 0.0213 0.0294
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0289 0.1485 0.1654
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.254 0.3504
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0083 0.0129
Echinococcus multilocularis cpg binding protein 0.0064 0.0254 0.0283
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0268 0.1367 0.2112
Echinococcus granulosus beta LACTamase domain containing family member 0.0289 0.1485 0.2049
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0131 0.0551
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0647 0.0892
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.1474 0.1641
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0046 0.0224
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.015 0.0725 0.112
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0447 0.3008
Schistosoma mansoni zinc finger protein 0.0023 0.0028 0.0039
Schistosoma mansoni tyrosine kinase 0.0385 0.2004 0.2765
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0044 0.0049
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.002 0.0027
Toxoplasma gondii thioredoxin reductase 0.0099 0.0447 0.3008
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0113 0.0156
Schistosoma mansoni coup transcription factor 0.0021 0.002 0.0027
Schistosoma mansoni lamin 0.0033 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.0081 0.035 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.1474 0.2034
Mycobacterium tuberculosis Probable lipase LipD 0.0289 0.1485 0.1485
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0592 0.3988
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.002 0.0027
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0093 0.0626
Loa Loa (eye worm) hypothetical protein 0.0268 0.1367 0.2112
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 0.2255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.0368 0.0568
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.002 0.003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0043 0.0067
Schistosoma mansoni smad1 5 8 and 0.0035 0.0097 0.0134
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0083 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0592 0.0592
Mycobacterium tuberculosis Conserved protein 0.0289 0.1485 0.1485
Trichomonas vaginalis alpha-glucosidase, putative 0.015 0.0725 0.3943
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.002 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0131 0.0693
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0005 0.0007
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0159 0.0219
Schistosoma mansoni hypothetical protein 0.002 0.0016 0.0022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0213 0.114
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0033 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0647 0.0892
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0647 0.0892
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0686
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0194 0.0268
Brugia malayi hypothetical protein 0.005 0.0179 0.0277
Onchocerca volvulus 0.0033 0.0083 0.0314
Echinococcus granulosus geminin 0.0716 0.3812 0.5259
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0093 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0725 0.488
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0044 0.0216
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0078 0.0087
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0093 0.0626
Schistosoma mansoni hypothetical protein 0.0085 0.0368 0.0507
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0093 0.1905
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0171
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.002 0.0022
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 0.1821
Echinococcus granulosus snurportin 1 0.0338 0.175 0.2414
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0093 0.0626
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0252 0.1278 0.8576
Echinococcus granulosus smad 0.0035 0.0097 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0647 0.0892
Trichomonas vaginalis alpha-glucosidase, putative 0.015 0.0725 0.3943
Echinococcus multilocularis geminin 0.0716 0.3812 0.4244
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0093 0.208
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0203 0.0225
Onchocerca volvulus 0.0289 0.1485 0.7249
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0005 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0359 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0213 0.1253
Loa Loa (eye worm) hypothetical protein 0.0085 0.0368 0.0568
Plasmodium falciparum thioredoxin reductase 0.0099 0.0447 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0022
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0005 0.003
Onchocerca volvulus 0.0289 0.1485 0.7249
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0647 0.0999
Echinococcus multilocularis tumor protein p63 0.0371 0.193 0.2149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1832 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0005 0.0006
Loa Loa (eye worm) MBCTL1 0.0053 0.0194 0.03
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0268 0.1367 0.2112
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.002 0.0031
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0093 0.043
Brugia malayi Cell death protein 3 precursor 0.006 0.0234 0.0362
Trichomonas vaginalis D-aminoacylase, putative 0.0289 0.1485 0.8104
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0005 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0287 0.1474 0.2277
Schistosoma mansoni importin beta-1 0.0032 0.0078 0.0108
Brugia malayi Smad1 0.0035 0.0097 0.015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1832 1
Trichomonas vaginalis alpha-glucosidase, putative 0.015 0.0725 0.3943
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0005 0.0005
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0005 0.003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0093 0.043
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0033 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0005 0.0006
Echinococcus multilocularis lamin dm0 0.0033 0.0083 0.0093
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0284 0.0316
Schistosoma mansoni hypothetical protein 0.0338 0.175 0.2414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0592 0.3862
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0647 0.0892
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0005 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0005 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0031
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0044 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0213 0.1433
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0213 0.1433
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0005 0.0007
Echinococcus multilocularis epidermal growth factor receptor 0.1203 0.6473 0.7208
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0686
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0046 0.0224
Trichomonas vaginalis esterase, putative 0.0289 0.1485 0.8104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.0368 0.041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0044 0.0216
Brugia malayi PHD-finger family protein 0.0028 0.0057 0.0088
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0005 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0284 0.1739
Trichomonas vaginalis alpha-glucosidase, putative 0.015 0.0725 0.3943
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0093 0.0626
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.114 0.7629
Schistosoma mansoni lamin 0.0033 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1832 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0102 0.0141
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0056 0.0211 0.0944
Echinococcus multilocularis neuropeptide receptor A26 0.0914 0.4897 0.5453
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0159 0.0177
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0093 0.0626
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0005 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0585 0.0807
Leishmania major hypothetical protein, conserved 0.0289 0.1485 1
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0213 0.114
Schistosoma mansoni hypothetical protein 0.0038 0.0113 0.0156
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0093 0.0626
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0093 0.208
Entamoeba histolytica hypothetical protein 0.0026 0.0046 0.0224
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0289 0.1485 0.2295
Schistosoma mansoni Smad4 0.0035 0.0097 0.0134
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0042 0.0279
Brugia malayi intermediate filament protein 0.0033 0.0083 0.0128
Plasmodium falciparum thioredoxin reductase 0.0034 0.0093 0.208
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0042 0.0057
Treponema pallidum NADH oxidase 0.0034 0.0093 0.0347
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0226 0.0349
Leishmania major glycosyl hydrolase-like protein 0.0056 0.0211 0.1418
Leishmania major trypanothione reductase 0.0099 0.0447 0.3008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0289 0.1485 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0113 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0027
Brugia malayi Protein kinase domain containing protein 0.0385 0.2004 0.3096
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0308 0.1661
Schistosoma mansoni alpha-glucosidase 0.0582 0.3084 0.4256
Leishmania major hypothetical protein, conserved 0.0078 0.033 0.2218
Echinococcus multilocularis apoptotic protease activating factor 1 0.006 0.0234 0.0261
Brugia malayi RNA, U transporter 1 0.009 0.0397 0.0613
Schistosoma mansoni tyrosine kinase 0.064 0.3397 0.4687
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0525 0.3535
Schistosoma mansoni microtubule-associated protein tau 0.1345 0.7248 1
Echinococcus multilocularis chromobox protein 1 0.0074 0.0308 0.0343
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.002 0.0027
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1832 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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