Detailed information for compound 578111

Basic information

Technical information
  • TDR Targets ID: 578111
  • Name: sodium (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4$l^ {6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxy late
  • MW: 255.223 | Formula: C8H10NNaO5S
  • H donors: 0 H acceptors: 5 LogP: -0.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)[C@@H]1N2C(=O)C[C@H]2S(=O)(=O)C1(C)C.[Na+]
  • InChi: 1S/C8H11NO5S.Na/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14;/h5-6H,3H2,1-2H3,(H,11,12);/q;+1/p-1/t5-,6+;/m1./s1
  • InChiKey: NKZMPZCWBSWAOX-IBTYICNHSA-M  


Substructure search Similarity search

Network

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Synonyms

  • sodium (2S,5R)-4,4,7-triketo-3,3-dimethyl-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • Sulbactam
  • 69388-84-7
  • C14001
  • CP-458992
  • Combactam
  • STOCK1N-08421
  • D02223
  • SBT
  • Sulbactam sodium (JP15/USP)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0015 0.0529
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0038 0.0156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0184 0.0202 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0044 0.0043
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0013 0.0225
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0009 0.0039
Brugia malayi mbt repeat family protein 0.0047 0.0028 0.0116
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0008 0.0246
Onchocerca volvulus 0.0092 0.0086 0.1499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0107 0.1872
Echinococcus multilocularis protein patched 0.0295 0.0344 0.0343
Mycobacterium ulcerans hypothetical protein 0.0072 0.006 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Plasmodium falciparum glutathione reductase 0.0095 0.009 0.2803
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0008 0.0008
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0002 0.0001
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.007 0.0058 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0003 0.0049
Entamoeba histolytica hypothetical protein 0.0043 0.0022 0.0259
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0056 0.004 0.0039
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0011 0.001
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0039 0.0164
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0185 0.0203 0.0203
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0066 0.2052
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.039 0.0465 0.1935
Entamoeba histolytica hypothetical protein 0.0326 0.0383 0.4535
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0006 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0018 0.0313
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0095 0.009 0.2803
Schistosoma mansoni aldehyde dehydrogenase 0.0184 0.0202 0.0202
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0008 0.0008
Giardia lamblia Pyruvate kinase 0.0033 0.0011 0.0954
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0011 0.001
Loa Loa (eye worm) oxidoreductase 0.0056 0.0039 0.0162
Echinococcus granulosus sterol regulatory element binding protein 0.0295 0.0344 0.0343
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0044 0.1361
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.019 0.021 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0083 0.1458
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0095 0.009 0.0089
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0013 0.0401
Brugia malayi protein C24B5.3 0.0042 0.0021 0.0089
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0039 0.0018 0.0211
Entamoeba histolytica hypothetical protein 0.0039 0.0018 0.0211
Echinococcus multilocularis Niemann Pick C1 protein 0.0688 0.0843 0.0843
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.009 0.2803
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.0185 0.0772
Giardia lamblia Replication factor C, subunit 1 0.0039 0.0018 0.1672
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.004 0.0039
Toxoplasma gondii patched family protein 0.0042 0.0021 0.0656
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0008 0.0008
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0028 0.0114
Plasmodium falciparum thioredoxin reductase 0.0275 0.0319 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0011 0.001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0015 0.0052
Trichomonas vaginalis set domain proteins, putative 0.0471 0.0567 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.006 0.186
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0015 0.0439
Toxoplasma gondii hypothetical protein 0.0042 0.0021 0.0656
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0036 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0066 0.2052
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0039 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0075 0.0064 0.1986
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Loa Loa (eye worm) hypothetical protein 0.0171 0.0185 0.0769
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0139 0.0522
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0066 0.2052
Mycobacterium tuberculosis Conserved protein 0.0072 0.006 0.0223
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0114
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0036 0.0148
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0118 0.0119 0.0118
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.004 0.0039
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0033 0.001 0.0311
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.004 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0013 0.0225
Entamoeba histolytica acyl-coA synthetase, putative 0.019 0.021 0.2488
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0036 0.0036
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.001 0.0034
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0056 0.0039 0.0146
Echinococcus multilocularis lysine specific demethylase 5A 0.0118 0.0119 0.0118
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0011 0.0042
Giardia lamblia NADH oxidase lateral transfer candidate 0.0095 0.009 0.84
Echinococcus multilocularis musashi 0.0055 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0001 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0699 0.0856 0.3212
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0011 0.0179
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.008 0.1395
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0028 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0184 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0074
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0008 0.0008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0006 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.006 0.0249
Loa Loa (eye worm) phosphatidylinositol 3 0.0109 0.0107 0.0442
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.006 0.186
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0069 0.0286
Plasmodium vivax patched family protein, putative 0.0042 0.0021 0.0656
Brugia malayi jmjC domain containing protein 0.0032 0.0008 0.0035
Chlamydia trachomatis DNA ligase 0.0039 0.0018 0.0672
Schistosoma mansoni nuclear hormone receptor 0.0056 0.004 0.0039
Mycobacterium ulcerans acetyl-CoA synthetase 0.0056 0.0039 0.0146
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0045 0.1395
Toxoplasma gondii propionate-CoA ligase 0.0056 0.0039 0.1221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0941
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0011 0.0045
Echinococcus multilocularis survival motor neuron protein 1 0.1914 0.2401 0.24
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Schistosoma mansoni lamin 0.0055 0.0038 0.0038
Schistosoma mansoni ap endonuclease 0.0075 0.0064 0.0063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.006 0.0059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.019 0.021 0.0787
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0044 0.0044
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0013 0.0013
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.007 0.2198
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0044 0.0043
Toxoplasma gondii aldehyde dehydrogenase 0.0184 0.0202 0.6348
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0056 0.0039 0.0039
Brugia malayi intermediate filament protein 0.0055 0.0038 0.0159
Echinococcus multilocularis peptidase Clp (S14 family) 0.0153 0.0163 0.0162
Leishmania major phosphatidylinositol 3-kinase, putative 0.0049 0.003 0.0938
Loa Loa (eye worm) patched family protein 0.0042 0.0021 0.0087
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0009 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0628 0.0767 0.2883
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0018 0.0313
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0015 0.0166
Brugia malayi Smad1 0.0033 0.0011 0.0045
Chlamydia trachomatis pyruvate kinase 0.0033 0.0011 0.0383
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0131 0.0131
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.0286 0.119
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Toxoplasma gondii exonuclease III APE 0.0075 0.0064 0.1986
Schistosoma mansoni bromodomain containing protein 0.0063 0.0049 0.0048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.019 0.021 0.0787
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Schistosoma mansoni inositol monophosphatase 0.0036 0.0015 0.0014
Toxoplasma gondii FATC domain-containing protein 0.0043 0.0022 0.0687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Echinococcus granulosus smad 0.0033 0.0011 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.003 0.0127
Brugia malayi protein C24B5.3 0.0042 0.0021 0.0089
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0011 0.0179
Schistosoma mansoni peptidase Clp (S14 family) 0.0233 0.0265 0.0264
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0028 0.0027
Loa Loa (eye worm) beta-lactamase 0.0072 0.006 0.0246
Brugia malayi DKFZp564C0469 protein 0.0039 0.0018 0.0076
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0015 0.0014
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0028 0.0027
Toxoplasma gondii patched family protein 0.0042 0.0021 0.0656
Brugia malayi beta-lactamase 0.0072 0.006 0.0249
Onchocerca volvulus 0.0042 0.0021 0.0368
Loa Loa (eye worm) hypothetical protein 0.0076 0.0066 0.027
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.006 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.006 0.1044
Echinococcus granulosus GPCR family 2 0.0079 0.0069 0.0068
Brugia malayi steroid hormone receptor 0.0056 0.004 0.0165
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0036
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.1495
Brugia malayi jmjC domain containing protein 0.0118 0.0119 0.0494
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0008 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0075 0.0064 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0036
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0095 0.009 0.3374
Loa Loa (eye worm) RNA binding protein 0.0128 0.0131 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0941
Plasmodium falciparum thioredoxin reductase 0.0095 0.009 0.2803
Loa Loa (eye worm) hypothetical protein 0.019 0.021 0.0874
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0056 0.0039 0.0146
Plasmodium falciparum acyl-CoA synthetase 0.0142 0.0149 0.4671
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.0064 0.1986
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0075 0.0064 0.5951
Onchocerca volvulus 0.0056 0.0039 0.0685
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Brugia malayi jmjC domain containing protein 0.0032 0.0008 0.0035
Mycobacterium tuberculosis Probable reductase 0.0628 0.0767 0.2883
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0153 0.0163 0.061
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0171 0.017
Loa Loa (eye worm) patched family protein 0.0042 0.0021 0.0087
Onchocerca volvulus 0.0042 0.0021 0.0368
Loa Loa (eye worm) hypothetical protein 0.0056 0.0039 0.0162
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0131 0.0548
Brugia malayi jmjC domain containing protein 0.0032 0.0008 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.1495
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.0064 0.1114
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0095 0.009 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0131 0.0131
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0018 0.0313
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0171 0.017
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0939
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0095 0.009 0.2803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.006 0.0059
Brugia malayi Pre-SET motif family protein 0.0059 0.0044 0.0183
Echinococcus granulosus lamin dm0 0.0055 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0007 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0095 0.009 0.2803
Leishmania major acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0008 0.0008
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0072 0.006 0.0223
Plasmodium vivax JmjC domain containing protein 0.0032 0.0008 0.0246
Leishmania major hypothetical protein, conserved 0.0032 0.0008 0.0246
Echinococcus multilocularis GPCR, family 2 0.0079 0.0069 0.0068
Echinococcus multilocularis pyruvate kinase 0.0033 0.0011 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0013 0.0225
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0039 0.1221
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0039 0.0018 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.004 0.0039
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0095 0.009 0.2803
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0011 0.0038
Echinococcus multilocularis geminin 0.0342 0.0403 0.0402
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0075 0.0064 0.1986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.006 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0939
Brugia malayi Patched protein homolog 1 0.0042 0.0021 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0069 0.0068
Schistosoma mansoni hypothetical protein 0.0079 0.0069 0.0068
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0095 0.009 0.2803
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0013 0.0225
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0069 0.0284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.004 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.0275 0.0319 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0028 0.0003 0.0087
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0039 0.0018 0.0558
Mycobacterium ulcerans acyl-CoA synthetase 0.019 0.021 0.0787
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0109 0.0107 0.0106
Onchocerca volvulus 0.019 0.021 0.37
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0056 0.0039 0.0146
Brugia malayi MH2 domain containing protein 0.0489 0.059 0.2459
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0233 0.0265 0.8308
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus multilocularis thioredoxin glutathione reductase 0.0277 0.032 0.0319
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0628 0.0767 0.2883
Echinococcus multilocularis protein dispatched 1 0.0337 0.0397 0.0396
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.007 0.0058 0.024
Brugia malayi AMP-binding enzyme family protein 0.019 0.021 0.0876
Onchocerca volvulus 0.0047 0.0028 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0018 0.0313
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Trypanosoma cruzi target of rapamycin kinase 3 0.009 0.0083 0.2602
Plasmodium vivax hypothetical protein, conserved 0.0072 0.006 0.186
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.006 0.1044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.004 0.0039
Mycobacterium tuberculosis Probable oxidoreductase 0.0699 0.0856 0.3219
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0013 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0132 0.0131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0139 0.0522
Schistosoma mansoni ap endonuclease 0.0075 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0091
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0001 0.0001
Echinococcus granulosus lamin 0.0055 0.0038 0.0038
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.006 0.0223
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0025 0.0025
Mycobacterium tuberculosis Conserved protein 0.0072 0.006 0.0223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.004 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0131 0.0131
Onchocerca volvulus 0.0059 0.0044 0.0764
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.004 0.0165
Loa Loa (eye worm) hypothetical protein 0.0142 0.0149 0.0619
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.0286 0.1188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0025 0.0025
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0018 0.0313
Brugia malayi Pax transcription activation domain interacting protein 0.0039 0.0018 0.0076
Onchocerca volvulus 0.0258 0.0297 0.5221
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0095 0.009 0.2803
Brugia malayi exodeoxyribonuclease III family protein 0.0075 0.0064 0.0266
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0109 0.0107 0.1259
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0036 0.0036
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0045 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0131 0.0545
Loa Loa (eye worm) hypothetical protein 0.0142 0.0149 0.0619
Onchocerca volvulus 0.0072 0.006 0.1044
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0699 0.0856 0.3219
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0013 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0185 0.0203 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.004 0.0039
Brugia malayi CHE-14 protein 0.0295 0.0344 0.1432
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0095 0.009 0.0335
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0008 0.0008
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0095 0.009 0.2803
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.004 0.0163
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.004 0.0039
Schistosoma mansoni Smad4 0.0033 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0041
Echinococcus granulosus nibrin 0.0039 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0074
Onchocerca volvulus 0.0055 0.0038 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.005 0.0876
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.004 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0142 0.0149 0.0619
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0056 0.0039 0.1221
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0015 0.0439
Echinococcus granulosus phd:f box containing protein 0.0032 0.0008 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0069 0.0068
Leishmania major 4-coumarate:coa ligase-like protein 0.019 0.021 0.6594
Schistosoma mansoni acetyl-CoA synthetase 0.0056 0.0039 0.0039
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0008 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0075 0.0064 0.0263
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.004 0.0689
Plasmodium falciparum glutathione reductase 0.0275 0.0319 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0025 0.0025
Brugia malayi Pre-SET motif family protein 0.0414 0.0495 0.206
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0013 0.0401
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus multilocularis serine protein kinase ATM 0.0043 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0044 0.0043
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0131 0.0545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0066 0.0065
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0028 0.0027
Brugia malayi mbt repeat family protein 0.0047 0.0028 0.0116
Schistosoma mansoni pyruvate kinase 0.0033 0.0011 0.001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 0.0992
Schistosoma mansoni smad1 5 8 and 0.0033 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0013 0.0225
Plasmodium vivax replication factor C subunit 1, putative 0.0039 0.0018 0.0558
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0156
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0056 0.0039 0.0461
Mycobacterium ulcerans beta-lactamase 0.0072 0.006 0.0222
Leishmania major 4-coumarate:coa ligase-like protein 0.019 0.021 0.6594
Onchocerca volvulus 0.0042 0.0021 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.004 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0025 0.0025
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0095 0.009 0.2803
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0095 0.009 0.2803
Brugia malayi jmjC domain containing protein 0.012 0.0121 0.0504
Echinococcus multilocularis lamin dm0 0.0055 0.0038 0.0038
Schistosoma mansoni topbp1 0.0039 0.0018 0.0018
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0095 0.009 0.3374
Brugia malayi AMP-binding enzyme family protein 0.019 0.021 0.0876
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 1
Schistosoma mansoni smad 0.0033 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0941
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0049 0.003 0.0938
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.004 0.0165
Schistosoma mansoni lamin 0.0055 0.0038 0.0038
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0109 0.0107 0.3337
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0109 0.0107 0.1259
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0171 0.0712
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0038 0.0159
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0009 0.0039
Loa Loa (eye worm) hypothetical protein 0.0362 0.0428 0.1782
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.024
Brugia malayi TAR-binding protein 0.0128 0.0131 0.0548
Loa Loa (eye worm) hypothetical protein 0.019 0.021 0.0874
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0011 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.019 0.021 0.6594
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.004 0.0165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0009 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0075 0.0064 0.1986
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0056 0.0039 0.0146
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.005 0.0876
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0074
Onchocerca volvulus 0.0042 0.0021 0.0368
Echinococcus granulosus lysine specific demethylase 5A 0.012 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.025 0.0286 0.1188
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.006 0.0223
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0011 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.1495
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0075 0.0064 0.2391
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0015 0.0246
Brugia malayi hypothetical protein 0.1914 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.0344 0.143
Schistosoma mansoni chromosome transmission fidelity factor 0.0039 0.0018 0.0018
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.004 0.0689
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0035 0.0145
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.0202 0.0758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.004 0.0163
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0013 0.0225
Schistosoma mansoni hypothetical protein 0.0326 0.0383 0.0382
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0628 0.0767 0.2878
Schistosoma mansoni jumonji/arid domain-containing protein 0.012 0.0121 0.012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.5669 0.7174 0.7174
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.009 0.0083 0.2602
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0049 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0079 0.0069 0.0284
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0109 0.0107 0.3337
Schistosoma mansoni hypothetical protein 0.0342 0.0403 0.0402
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0031 0.0007 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Loa Loa (eye worm) transcription factor SMAD2 0.0489 0.059 0.2457
Trypanosoma brucei target of rapamycin kinase 3, putative 0.009 0.0083 0.2602
Brugia malayi glutathione reductase 0.0275 0.0319 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0939
Brugia malayi MH2 domain containing protein 0.0033 0.0011 0.0045
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0036 0.0036
Echinococcus granulosus histone lysine methyltransferase setb 0.0076 0.0066 0.0065
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0039 0.0018 0.0076
Onchocerca volvulus 0.0072 0.006 0.1044
Giardia lamblia GTOR 0.0109 0.0107 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.004 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.004 0.0163
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0015 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0039 0.0164
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.004 0.0689
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0056 0.0039 0.0162
Plasmodium vivax acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.0286 0.119
Onchocerca volvulus 0.0063 0.0049 0.0855
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Brugia malayi hypothetical protein 0.0042 0.0021 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.004 0.0165
Entamoeba histolytica hypothetical protein 0.0326 0.0383 0.4535
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0013 0.0401
Echinococcus granulosus peptidase Clp S14 family 0.0153 0.0163 0.0162
Brugia malayi hypothetical protein 0.0042 0.0021 0.0089
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0056 0.0039 0.0146
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0045 0.0166
Toxoplasma gondii patched family protein 0.0042 0.0021 0.0656
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.019 0.021 0.0787
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0049 0.003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.019 0.021 0.0789
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.001 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.004 0.0163
Loa Loa (eye worm) inositol-1 0.0036 0.0015 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0066 0.2052
Brugia malayi RNA binding protein 0.0128 0.0131 0.0548
Brugia malayi hypothetical protein 0.0326 0.0383 0.1594
Entamoeba histolytica hypothetical protein 0.0326 0.0383 0.4535
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.006 0.0223
Plasmodium falciparum replication factor C subunit 1, putative 0.0039 0.0018 0.0558
Brugia malayi jmjC domain containing protein 0.0032 0.0008 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.003 0.0526
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0031 0.0952
Brugia malayi hypothetical protein 0.005 0.0031 0.013
Loa Loa (eye worm) hypothetical protein 0.0142 0.0149 0.0619
Toxoplasma gondii hypothetical protein 0.008 0.007 0.2198
Brugia malayi ecdysteroid receptor 0.0056 0.004 0.0165
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.004 0.0165
Leishmania major pyruvate kinase 0.0033 0.0011 0.0318
Toxoplasma gondii NADPH-glutathione reductase 0.0095 0.009 0.2803
Loa Loa (eye worm) hypothetical protein 0.0258 0.0297 0.1233
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0056 0.0039 0.0146
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.004 0.0039
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.0003 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0075 0.0064 0.0749
Onchocerca volvulus Protein patched homolog 0.0042 0.0021 0.0368
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.0246
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2121 0.2665 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0011 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.003 0.0526
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0121 0.0502
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0025 0.0001 0.0001
Echinococcus multilocularis sterol regulatory element binding protein 0.0295 0.0344 0.0343
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.007 0.2646
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.004 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0014 0.0013
Loa Loa (eye worm) thioredoxin reductase 0.0275 0.0319 0.1325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Loa Loa (eye worm) hypothetical protein 0.0056 0.0039 0.0162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0003 0.0014
Schistosoma mansoni jumonji domain containing protein 0.0118 0.0119 0.0118
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.006 0.0223
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0171 0.017
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0131 0.0131
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0056 0.0039 0.0146
Brugia malayi Bromodomain containing protein 0.0075 0.0064 0.0265
Brugia malayi Inositol-1 0.0036 0.0015 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0184 0.0202 0.0759
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0109 0.0107 0.0106
Loa Loa (eye worm) MBCTL1 0.0053 0.0036 0.0148
Trypanosoma brucei glucosidase, putative 0.0035 0.0013 0.0401
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0039 0.0018 0.0558
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.003 0.0109
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0045 0.0044
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0056 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0009 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0628 0.0767 0.2883
Leishmania major acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0095 0.009 0.0374
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.006 0.0223
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0018 0.0313
Schistosoma mansoni DNA ligase IV 0.0039 0.0018 0.0018
Echinococcus granulosus geminin 0.0342 0.0403 0.0402
Leishmania major pyruvate kinase 0.0033 0.0011 0.0318
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0011 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.004 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0054 0.0941
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0184 0.0202 0.6348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.003 0.0526
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0049 0.003 0.003
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0056 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0033
Echinococcus multilocularis expressed conserved protein 0.0647 0.079 0.079
Trichomonas vaginalis conserved hypothetical protein 0.0295 0.0344 0.6056
Schistosoma mansoni alpha glucosidase 0.0035 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0049 0.003 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Echinococcus multilocularis smad 0.0033 0.0011 0.001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0039 0.1221
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.004 0.0039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0118 0.0119 0.0118
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0056 0.0039 0.0164
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus multilocularis Niemann Pick C1 protein 0.0984 0.1219 0.1218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0025 0.0025
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Brugia malayi hypothetical protein 0.0039 0.0018 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0066 0.2052
Onchocerca volvulus 0.0056 0.0039 0.0685
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0044 0.0044
Brugia malayi hypothetical protein 0.0039 0.0018 0.0076
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0008 0.0008
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0011 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.004 0.0165
Onchocerca volvulus 0.0072 0.006 0.1044
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0036 0.0036
Brugia malayi hypothetical protein 0.0032 0.0009 0.0039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0233 0.0265 0.1101
Loa Loa (eye worm) hypothetical protein 0.0688 0.0843 0.3511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0009 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0041 0.004
Schistosoma mansoni patched 1 0.0295 0.0344 0.0343
Plasmodium vivax acyl-CoA synthetase, putative 0.0142 0.0149 0.4671
Brugia malayi Niemann-Pick C1 protein precursor 0.0688 0.0843 0.3512
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Schistosoma mansoni coup transcription factor 0.0056 0.004 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.004 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0326 0.0383 0.0382
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.0246
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.006 0.0223
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0233 0.0265 0.8308
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0069 0.0068
Treponema pallidum exodeoxyribonuclease (exoA) 0.0075 0.0064 0.2391
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.0246
Entamoeba histolytica hypothetical protein 0.0326 0.0383 0.4535
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0049 0.003 0.0938
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0048 0.1495
Loa Loa (eye worm) hypothetical protein 0.0054 0.0037 0.0151
Trypanosoma cruzi FHA domain containing protein, putative 0.0039 0.0018 0.0558
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0056 0.0039 0.0146
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0043 0.0022 0.0687
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0628 0.0767 0.2883
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0045 0.0166
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0011 0.0318
Brugia malayi MH2 domain containing protein 0.0033 0.0011 0.0045
Mycobacterium ulcerans TetR family transcriptional regulator 0.2121 0.2665 1
Schistosoma mansoni retinoic acid receptor RXR 0.0056 0.004 0.0039
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0013 0.0225
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0011 0.0179
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2121 0.2665 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0109 0.0107 0.0106
Plasmodium vivax SET domain protein, putative 0.0059 0.0044 0.1361
Brugia malayi Patched related family protein 4 0.0042 0.0021 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.019 0.021 0.0787
Mycobacterium leprae conserved hypothetical protein 0.0072 0.006 0.0222
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0039 0.1221
Loa Loa (eye worm) hypothetical protein 0.0142 0.0149 0.0619
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.004 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.005 0.0876
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.006 0.0246
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0013 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.004 0.0165
Brugia malayi hypothetical protein 0.0077 0.0066 0.0274
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0013 0.0151
Schistosoma mansoni hypothetical protein 0.0171 0.0185 0.0185
Echinococcus multilocularis thyroid hormone receptor alpha 0.0185 0.0203 0.0203
Schistosoma mansoni transcription factor LCR-F1 0.0326 0.0383 0.0382
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0011 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0326 0.0383 0.0382
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.004 0.0039
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0041 0.1278
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0153 0.0163 0.061
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0056 0.0039 0.0164
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0011 0.0042
Echinococcus granulosus tumor protein p63 0.1764 0.221 0.221
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0011 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0025 0.0103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.019 0.021 0.0789
Brugia malayi Bromodomain containing protein 0.0038 0.0017 0.0071
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0056 0.0039 0.0146
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0011 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.004 0.0165
Loa Loa (eye worm) patched family protein 0.0042 0.0021 0.0087
Echinococcus granulosus Smad4 0.0033 0.0011 0.001
Schistosoma mansoni inositol monophosphatase 0.0036 0.0015 0.0014
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0056 0.0039 0.1221
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0039 0.0018 0.0672
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Brugia malayi glutamate synthase 0.0025 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0056 0.0039 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0039 0.0164
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0095 0.009 0.3374
Schistosoma mansoni smad1 5 8 and 0.0033 0.0011 0.001
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0045 0.0044
Trypanosoma brucei trypanothione reductase 0.0275 0.0319 1
Mycobacterium ulcerans transcriptional regulator 0.2121 0.2665 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0045 0.0187
Trichomonas vaginalis esterase, putative 0.0072 0.006 0.1044
Echinococcus multilocularis lamin 0.0055 0.0038 0.0038
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0056 0.0981
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Brugia malayi hypothetical protein 0.0042 0.0021 0.0089
Echinococcus granulosus intermediate filament protein 0.0055 0.0038 0.0038
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0233 0.0265 0.8308
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0095 0.009 0.2803
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0049 0.003 0.0938
Brugia malayi Patched related family protein 12 0.0042 0.0021 0.0089
Loa Loa (eye worm) glutathione reductase 0.0275 0.0319 0.1325
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0142 0.0149 0.0559
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0018 0.0558
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.019 0.021 0.0787
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.003 0.0124
Leishmania major hypothetical protein, conserved 0.0077 0.0066 0.2052
Brugia malayi hypothetical protein 0.0042 0.0021 0.0089
Treponema pallidum DNA ligase (lig) 0.0039 0.0018 0.0672
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0066 0.0065
Brugia malayi Probable ClpP-like protease 0.0233 0.0265 0.1103
Toxoplasma gondii patched family protein 0.0042 0.0021 0.0656
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.004 0.0165
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0008 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0095 0.009 0.2803
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0028 0.0481
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0008 0.0246
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0069 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0139 0.0522
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.004 0.0165
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0132 0.0131
Loa Loa (eye worm) patched family protein 0.0042 0.0021 0.0087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0171 0.071
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0142 0.0149 0.0558
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0045 0.0167
Brugia malayi Myosin head containing protein 0.0042 0.0021 0.0089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.0202 0.0758
Plasmodium vivax glutathione reductase, putative 0.0275 0.0319 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0069 0.0286
Brugia malayi nuclear receptor RXR 0.0032 0.0009 0.0039
Brugia malayi AMP-binding enzyme family protein 0.019 0.021 0.0876
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0018 0.0313
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0095 0.009 0.0335
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0131 0.0131
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.006 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0076 0.0066 0.0065
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.019 0.021 0.0787
Onchocerca volvulus 0.0042 0.0021 0.0368
Brugia malayi Patched related family protein 10 0.0042 0.0021 0.0089
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0275 0.0319 0.1196
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.0495 0.2058
Toxoplasma gondii thioredoxin reductase 0.0275 0.0319 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0688 0.0843 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0013 0.0401
Schistosoma mansoni hypothetical protein 0.0079 0.0069 0.0068
Echinococcus multilocularis Smad4 0.0033 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0285 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0074
Schistosoma mansoni hypothetical protein 0.0285 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.0246
Schistosoma mansoni hypothetical protein 0.0034 0.0012 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.0064 0.1114
Echinococcus granulosus survival motor neuron protein 1 0.1914 0.2401 0.24
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0083 0.1458
Entamoeba histolytica acyl-CoA synthetase, putative 0.019 0.021 0.2488
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.006 0.1044
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0233 0.0265 0.0264
Loa Loa (eye worm) MH2 domain-containing protein 0.0489 0.059 0.2457
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0075 0.0064 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.004 0.0039
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.019 0.021 0.0787
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0139 0.0522
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.008 0.007 0.0262
Loa Loa (eye worm) hypothetical protein 0.0056 0.004 0.0163
Echinococcus multilocularis nibrin 0.0039 0.0018 0.0018
Trichomonas vaginalis glutathione reductase, putative 0.0095 0.009 0.1573
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0109 0.0107 0.3337
Schistosoma mansoni hypothetical protein 0.0079 0.0069 0.0068
Onchocerca volvulus 0.0471 0.0567 1
Brugia malayi MH1 domain containing protein 0.0033 0.0011 0.0045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0039 0.0146
Echinococcus granulosus thioredoxin glutathione reductase 0.0277 0.032 0.0319
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0142 0.0149 0.5623
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0011 0.0045
Trichomonas vaginalis antibiotic synthetase, putative 0.0056 0.0039 0.0685
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0011 0.0318
Loa Loa (eye worm) hypothetical protein 0.1914 0.2401 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0699 0.0856 0.3219
Plasmodium vivax thioredoxin reductase, putative 0.0275 0.0319 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0025 0.0105
Schistosoma mansoni cellular tumor antigen P53 0.0258 0.0297 0.0296
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0002 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0066 0.2052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.0202 0.0758
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0095 0.009 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0018 0.0313
Loa Loa (eye worm) patched family protein 0.0042 0.0021 0.0087
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0109 0.0107 0.3337
Schistosoma mansoni hypothetical protein 0.03 0.0349 0.0349
Onchocerca volvulus 0.0039 0.0018 0.0313
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.0552 0.2074
Echinococcus granulosus Protein patched homolog 1 0.0295 0.0344 0.0343
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.004 0.0165
Schistosoma mansoni alpha-glucosidase 0.0137 0.0143 0.0142
Brugia malayi hypothetical protein 0.0032 0.0009 0.0039
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0233 0.0265 0.0264
Trichomonas vaginalis mercuric reductase, putative 0.0095 0.009 0.1573
Schistosoma mansoni pyruvate kinase 0.0033 0.0011 0.001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0153 0.0163 0.0608
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Echinococcus multilocularis pyruvate kinase 0.0033 0.0011 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.006 0.0222
Loa Loa (eye worm) hypothetical protein 0.0077 0.0066 0.0272
Toxoplasma gondii ATPase, AAA family protein 0.0039 0.0018 0.0558
Echinococcus granulosus expressed conserved protein 0.0647 0.079 0.079
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0028 0.0027
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0028 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.004 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0107 0.1872
Trichomonas vaginalis replication factor C large subunit, putative 0.0039 0.0018 0.0313
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2117 0.2659 1
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0039 0.0164
Onchocerca volvulus 0.0042 0.0021 0.0368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Treponema pallidum NADH oxidase 0.0095 0.009 0.3374
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0083 0.1458
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Echinococcus granulosus tar DNA binding protein 0.0128 0.0131 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.004 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Entamoeba histolytica acyl-CoA synthetase, putative 0.019 0.021 0.2488
Trichomonas vaginalis antibiotic synthetase, putative 0.0056 0.0039 0.0685
Brugia malayi MH1 domain containing protein 0.0033 0.0011 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0013 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.004 0.0039
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0109 0.0107 0.3337
Toxoplasma gondii ABC1 family protein 0.0072 0.006 0.186
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0095 0.009 0.0335
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.006 0.1044
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0184 0.0202 0.0202
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0066 0.2052
Schistosoma mansoni topbp1 0.0039 0.0018 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0008 0.0033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 0.8308
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0018 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0011 0.0042
Echinococcus multilocularis pyruvate kinase 0.0026 0.0002 0.0001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0095 0.009 0.2803
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0056 0.0039 0.0146
Echinococcus granulosus Niemann Pick C1 protein 0.0688 0.0843 0.0843
Onchocerca volvulus 0.0055 0.0038 0.0663
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0011 0.0318
Brugia malayi beta-lactamase family protein 0.0072 0.006 0.0249
Schistosoma mansoni hypothetical protein 0.039 0.0465 0.0464
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0008 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.003 0.0526
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0056 0.0039 0.0146
Echinococcus granulosus FTZ F1 alpha 0.0056 0.004 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.7892 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.006 0.186
Schistosoma mansoni hypothetical protein 0.0129 0.0132 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0043 0.0022 0.0022
Brugia malayi topoisomerase 0.0039 0.0018 0.0076
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0056 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0285 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.0246
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0295 0.0344 0.143
Schistosoma mansoni intermediate filament proteins 0.0055 0.0038 0.0038
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0015 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.004 0.0165
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0008 0.0008
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0008 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0018 0.0313
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0038 0.0156
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.006 0.0223
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0011 0.0038
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0049 0.003 0.0938
Brugia malayi beta-lactamase family protein 0.0072 0.006 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0003 0.0049
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0075 0.0064 0.0237
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0056 0.0039 0.0146
Onchocerca volvulus 0.039 0.0465 0.8186
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0011 0.001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0628 0.0767 0.2883
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.1495
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0056 0.0039 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.003 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0107 0.1872
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0039 0.0146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.019 0.021 0.0787
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0011 0.0318
Brugia malayi Thioredoxin reductase 0.0275 0.0319 0.1327
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0233 0.0265 0.0992
Echinococcus multilocularis replication factor c subunit 1 0.0039 0.0018 0.0018
Leishmania major trypanothione reductase 0.0275 0.0319 1
Mycobacterium leprae Probable lipase LipE 0.0072 0.006 0.0222
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0083 0.1458
Toxoplasma gondii target of rapamycin (TOR), putative 0.0086 0.0077 0.2412
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0075 0.0064 0.0063
Leishmania major hypothetical protein, conserved 0.0072 0.006 0.186
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0039 0.0018 0.0558
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0022 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.006 0.1044
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0015 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.004 0.0165
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0011 0.0179
Mycobacterium ulcerans lipase LipD 0.0072 0.006 0.0222
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.0042
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0015 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.1353
Echinococcus granulosus pyruvate kinase 0.0033 0.0011 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0109 0.0107 0.3337
Brugia malayi nuclear hormone receptor 0.0056 0.004 0.0165
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0056 0.0039 0.0146
Schistosoma mansoni jumonji/arid domain-containing protein 0.012 0.0121 0.012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.004 0.0039
Plasmodium falciparum pyruvate kinase 0.0033 0.0011 0.0318
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0008 0.0246
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0039 0.1221
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0056 0.0039 0.0146
Schistosoma mansoni smad1 5 8 and 0.0033 0.0011 0.001
Onchocerca volvulus 0.0056 0.004 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0022 0.0385
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0008 0.0246
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.004 0.0039
Brugia malayi Patched family protein 0.0042 0.0021 0.0089
Brugia malayi nuclear receptor NHR-88 0.0056 0.004 0.0165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.006 0.1045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0075 0.0064 0.1986
Onchocerca volvulus 0.0042 0.0021 0.0368
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.0064 0.1986
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.007 0.2198
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0036 0.0036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0013 0.0151
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 0.0992
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.0003 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.004 0.0039
Mycobacterium ulcerans hypothetical protein 0.019 0.021 0.0787
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.0003 0.0033
Loa Loa (eye worm) Smad1 0.0033 0.0011 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0001 0.0002
Schistosoma mansoni survival motor neuron protein 0.039 0.0465 0.0464
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803
Plasmodium falciparum lipid/sterol:H+ symporter 0.0042 0.0021 0.0656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.004 0.0163
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0056 0.0039 0.1221
Echinococcus granulosus Niemann Pick C1 protein 0.0984 0.1219 0.1218
Echinococcus granulosus replication factor c subunit 1 0.0039 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.004 0.0163
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0095 0.009 0.0335
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0233 0.0265 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0009 0.0009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0699 0.0857 0.0856
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0015 0.0246
Echinococcus multilocularis tumor protein p63 0.1764 0.221 0.221
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0095 0.009 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0107 0.0444
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.0246
Schistosoma mansoni alpha-glucosidase 0.0137 0.0143 0.0142
Onchocerca volvulus 0.0056 0.0039 0.0685
Schistosoma mansoni hypothetical protein 0.0079 0.0069 0.0068
Onchocerca volvulus Protein patched homolog 0.0042 0.0021 0.0368
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.1495
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.0022 0.0687
Echinococcus granulosus serine protein kinase ATM 0.0043 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0001 0.0002
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0039 0.0018 0.0067
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0015 0.0246
Schistosoma mansoni microtubule-associated protein tau 0.7892 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.006 0.1045
Schistosoma mansoni hypothetical protein 0.0342 0.0403 0.0402
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0046 0.0027 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.1495
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0056 0.0039 0.0162
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0031 0.0959
Schistosoma mansoni hypothetical protein 0.0285 0.033 0.033
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0008 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0083 0.1458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0095 0.009 0.2803

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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