Detailed information for compound 585046

Basic information

Technical information
  • TDR Targets ID: 585046
  • Name: (2S)-N-[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3- (4-hydroxyphenyl)propanoyl]amino]propanoyl]am ino]acetyl]amino]-3-phenyl-propanoyl]-2-[2-[[ (2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3 -(4-hydroxyphenyl)propanoyl]amino]propanoyl]a mino]acetyl]amino]-3-phenyl-propanoyl]amino]- 4-methyl-pentanoyl]amino]ethylamino]-4-methyl -pentanamide
  • MW: 1163.37 | Formula: C60H82N12O12
  • H donors: 14 H acceptors: 12 LogP: 3.34 Rotable bonds: 43
    Rule of 5 violations (Lipinski): 4
  • SMILES: Oc1ccc(cc1)C[C@@H](C(=O)N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)NC(=O)[C@H](CC(C)C)NCCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)C)CC(C)C)Cc1ccccc1)C)N
  • InChi: 1S/C60H82N12O12/c1-35(2)27-47(58(82)72-60(84)50(32-40-15-11-8-12-16-40)70-52(76)34-66-54(78)38(6)68-56(80)46(62)30-42-19-23-44(74)24-20-42)63-25-26-64-57(81)48(28-36(3)4)71-59(83)49(31-39-13-9-7-10-14-39)69-51(75)33-65-53(77)37(5)67-55(79)45(61)29-41-17-21-43(73)22-18-41/h7-24,35-38,45-50,63,73-74H,25-34,61-62H2,1-6H3,(H,64,81)(H,65,77)(H,66,78)(H,67,79)(H,68,80)(H,69,75)(H,70,76)(H,71,83)(H,72,82,84)/t37-,38-,45+,46+,47+,48+,49+,50+/m1/s1
  • InChiKey: JRWJPZLRGAHOTB-YZWQYETPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-N-[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxopropyl]amino]-1-oxoethyl]amino]-1-oxo-3-phenylpropyl]-2-[2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxopropyl]amino]-1-oxoethyl]amino]-1-oxo-3-phenylpropyl]amino]-4-methyl-1-oxopentyl]amino]ethylamino]-4-methylpentanamide
  • (2S)-N-[(2S)-2-[2-[[(2R)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]ethanoylamino]-3-phenyl-propanoyl]-2-[2-[[(2S)-2-[[(2S)-2-[2-[[(2R)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]ethanoylamino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]ethylamino]-4-methyl-pentanamide
  • (2S)-N-[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenyl-propanoyl]-2-[2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]ethylamino]-4-methyl-valeramide
  • (2S)-N-[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]-2-[2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]ethylamino]-4-methylpentanamide
  • enkephalinamide-Leu, Ala(2)-aminoethyl dimer-
  • (2S)-N-[(2S)-2-[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]ethanoylamino]-3-phenyl-propanoyl]-2-[2-[[(2S)-2-[[(2S)-2-[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]ethanoylamino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]ethylamino]-4-methyl-pentanamide
  • 82221-89-4
  • 2-Ala-aminoethyl dimer-leu-enkephalinamide
  • DPE2
  • Enkephalinamide-leu, alanine(2)-aminoethyl dimer-
  • L-Leucinamide, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-N-(2-((N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)amino)ethyl)-
  • Leu-enkephalinamide, ala(2) aminoethyl dimer-
  • Leucine-enkephalinamide, ala(2)-aminoethyl dimer-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0017 0.0015 0.0142
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0039 0.0194
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0046 0.0046
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0017 0.0482
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.0194 0.0194
Echinococcus multilocularis serotonin receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0046 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0052 0.0052
Mycobacterium leprae Conserved hypothetical protein 0.1129 0.227 0.4134
Brugia malayi Cathepsin L-like precursor 0.0017 0.0015 0.007
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.016 0.0305 0.0552
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0108 0.0201 0.1038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Brugia malayi Serotonin receptor 0.0032 0.0046 0.0231
Onchocerca volvulus 0.0011 0.0004 0.0024
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Brugia malayi G-protein coupled receptor 0.0032 0.0046 0.0231
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus multilocularis sodium channel protein 0.0034 0.0051 0.0051
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0046 0.0046
Echinococcus granulosus cathepsin l1 0.0017 0.0015 0.0015
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0046 0.0046
Echinococcus granulosus orexin receptor type 2 0.0032 0.0046 0.0046
Echinococcus granulosus g protein coupled receptor 0.0032 0.0046 0.0046
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0000017996
Mycobacterium tuberculosis Conserved protein 0.0108 0.0201 0.0275
Loa Loa (eye worm) hypothetical protein 0.0119 0.0223 0.1152
Brugia malayi hypothetical protein 0.0027 0.0035 0.0175
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0015 0.0015
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0058
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni hypothetical protein 0.0048 0.0079 0.0079
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.01 0.01
Schistosoma mansoni glutaminase 0.0271 0.053 0.053
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Echinococcus granulosus kelch ECH associated protein 1 0.0187 0.0361 0.0361
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 0.4008
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.011 0.5418
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3357 0.6788 1
Brugia malayi glutaminase DH11.1 0.0271 0.053 0.2751
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.017
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0087 0.4013
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.0306 0.0306
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.016 0.0305 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0029 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Onchocerca volvulus 0.0017 0.0015 0.0142
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0022 0.0108
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0108 0.0201 0.0275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0082
Brugia malayi beta-lactamase family protein 0.0108 0.0201 0.1035
Mycobacterium ulcerans lipase LipD 0.0108 0.0201 0.0361
Schistosoma mansoni ferritin 0.0026 0.0033 0.0033
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0015 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.007 0.0356
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0026
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0046 0.0046
Brugia malayi Doublecortin family protein 0.002 0.0022 0.0108
Toxoplasma gondii ABC1 family protein 0.0108 0.0201 0.6549
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0046 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0029 0.0935
Schistosoma mansoni histamine h1 receptor 0.0032 0.0046 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0029 0.0995
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 0.4008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.011
Echinococcus multilocularis voltage dependent calcium channel 0.0081 0.0145 0.0145
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.016 0.0305 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0049 0.0081 0.3957
Plasmodium vivax vivapain-2 0.0017 0.0015 0.0418
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0029 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0029 0.0029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.0046
Leishmania major hypothetical protein, conserved 0.0027 0.0035 0.1263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0046 0.0234
Leishmania major cathepsin L-like protease 0.0017 0.0015 0.0194
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0058 0.01 0.01
Loa Loa (eye worm) twinkle helicase 0.0109 0.0203 0.105
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0046 0.0046
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0002 0.0002
Echinococcus granulosus serotonin receptor 0.0032 0.0046 0.0046
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0058 0.0592
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0029 0.0049
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2715 0.5487 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.1086
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.1086
Schistosoma mansoni loxhd1 0.002 0.0022 0.0022
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0081 0.0145 0.0145
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0084 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Schistosoma mansoni neuropeptide receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0108 0.0201 0.1038
Schistosoma mansoni voltage-gated cation channel 0.0081 0.0145 0.0145
Onchocerca volvulus 0.0032 0.0046 0.0472
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.011 0.011
Echinococcus multilocularis somatostatin receptor 0.0032 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0015 0.0418
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0033 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0002
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0029 0.0029
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Schistosoma mansoni ferritin 0.0026 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.011 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0137 0.0137
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.0592
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0053
Brugia malayi hypothetical protein 0.001 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0046 0.0472
Loa Loa (eye worm) fibroinase 0.0017 0.0015 0.0072
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0507 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus voltage dependent calcium channel 0.0081 0.0145 0.0145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0019 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0002 0.0002
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0006 0.0006
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0046 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0098 0.0098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0015 0.0134
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0015 0.0142
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Chlamydia trachomatis recombinase RecA 0.0107 0.0198 0.2591
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 0.4008
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0058 0.01 0.0512
Toxoplasma gondii exonuclease III APE 0.0018 0.0019 0.0542
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0201 0.2105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0104 0.0104
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0058 0.01 0.051
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.01 0.051
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0029 0.0049
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.005 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0035 0.1086
Leishmania major cathepsin L-like protease 0.0063 0.011 0.52
Onchocerca volvulus 0.0032 0.0046 0.0472
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0081 0.0145 0.0145
Brugia malayi neuropeptide F receptor 0.0032 0.0046 0.0231
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0015 0.0015
Echinococcus multilocularis geminin 0.0507 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.2472
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0033 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Echinococcus multilocularis lamin 0.0026 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0201 0.0201
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0004
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0003 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0084 0.27
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0014 0.0384
Schistosoma mansoni lamin 0.0026 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0119 0.0223 0.1152
Schistosoma mansoni opsin-like receptor 0.0032 0.0046 0.0046
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0048 0.2303
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0019 0.003
Onchocerca volvulus 0.0195 0.0377 0.3988
Entamoeba histolytica cysteine protease, putative 0.0017 0.0015 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0029 0.0143
Onchocerca volvulus 0.0032 0.0046 0.0472
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0079 0.0079
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0201 0.0201
Schistosoma mansoni amine GPCR 0.0032 0.0046 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0089 0.0161 0.0832
Echinococcus granulosus carbonic anhydrase 0.0058 0.01 0.01
Echinococcus granulosus kelch ECH associated protein 1 like 0.0187 0.0361 0.0361
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0201 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0201 0.0275
Brugia malayi Dopamine receptor protein 2 0.0032 0.0046 0.0231
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0004 0.0004
Echinococcus granulosus lamin 0.0026 0.0035 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0542
Echinococcus granulosus somatostatin receptor 0.0032 0.0046 0.0046
Schistosoma mansoni neuropeptide receptor 0.0032 0.0046 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0104 0.0104
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0015 0.0418
Mycobacterium ulcerans beta-lactamase 0.0108 0.0201 0.0361
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0093 0.2989
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0046 0.0046
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0201 0.0361
Schistosoma mansoni lipoxygenase 0.0057 0.0096 0.0096
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0019 0.1931
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0201 0.0361
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0046 0.0046
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0033 0.0028
Loa Loa (eye worm) hypothetical protein 0.0058 0.01 0.0512
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.011 0.5418
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0035 0.0175
Brugia malayi Cathepsin L-like precursor 0.0017 0.0015 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0016 0.0435
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0046 0.0231
Echinococcus granulosus ferritin 0.0026 0.0033 0.0033
Mycobacterium ulcerans hypothetical protein 0.0024 0.0029 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Brugia malayi Melatonin receptor type 1A 0.0032 0.0046 0.0231
Loa Loa (eye worm) inositol-1 0.0038 0.0058 0.0296
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.0827
Brugia malayi intermediate filament protein 0.0026 0.0035 0.0173
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0002 0.0004
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0046 0.0046
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0201 0.0201
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0201 0.2105
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0002 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0082
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0034 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0029 0.0049
Echinococcus granulosus RUN 0.002 0.0022 0.0022
Mycobacterium leprae Probable lipase LipE 0.0108 0.0201 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0046 0.0046
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0081 0.0145 0.0145
Onchocerca volvulus 0.0101 0.0187 0.1965
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0049 0.0081 0.3957
Onchocerca volvulus 0.0032 0.0046 0.0472
Schistosoma mansoni hypothetical protein 0.0032 0.0046 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.1659
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0383 0.0757 1
Schistosoma mansoni polycystin 1-related 0.002 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Echinococcus multilocularis cpg binding protein 0.0032 0.0046 0.0046
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0002 0.0002
Schistosoma mansoni Replicative DNA helicase 0.0383 0.0757 0.0757
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0019 0.0089
Loa Loa (eye worm) hypothetical protein 0.0081 0.0145 0.0748
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0017 0.0193
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0081 0.0145 0.0145
Brugia malayi putative neuropeptide receptor 0.0032 0.0046 0.0231
Onchocerca volvulus 0.002 0.0022 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0081 0.0145 0.0145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.0108 0.0201 0.1038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0087 0.4284
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0046 0.0046
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0048 0.2303
Schistosoma mansoni adenoreceptor 0.0032 0.0046 0.0046
Echinococcus granulosus nibrin 0.001 0.0002 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0046 0.0046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0107 0.3457
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0058 0.1842
Loa Loa (eye worm) hypothetical protein 0.0058 0.01 0.0512
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0077 0.0392
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0002 0.0002
Echinococcus granulosus lamin dm0 0.0026 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0014 0.0067
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0015 0.0418
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0014 0.0014
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0029 0.0022
Echinococcus granulosus sex peptide receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus multilocularis GPCR, family 2 0.0048 0.0079 0.0079
Echinococcus multilocularis sex peptide receptor 0.0032 0.0046 0.0046
Schistosoma mansoni topbp1 0.001 0.0002 0.0002
Brugia malayi MAP kinase sur-1 0.0052 0.0087 0.0446
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0046 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0046 0.0046
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0015 0.0194
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0089 0.0161 0.0832
Echinococcus multilocularis carbonic anhydrase II 0.0058 0.01 0.01
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.011 0.5418
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0058 0.208
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus granulosus neuropeptide receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0046 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0046 0.0234
Onchocerca volvulus 0.0032 0.0046 0.0472
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0058 0.01 0.4903
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0024 0.012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0288 0.1493
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0029 0.0935
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0201 0.1035
Brugia malayi neuropeptide F receptor 0.0032 0.0046 0.0231
Loa Loa (eye worm) glutaminase 0.0271 0.053 0.2753
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.032 0.032
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0087 0.0087
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0046 0.0234
Schistosoma mansoni intermediate filament proteins 0.0026 0.0035 0.0035
Echinococcus multilocularis cysteine protease 0.0017 0.0015 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0058 0.01 0.01
Trichomonas vaginalis esterase, putative 0.0108 0.0201 0.2105
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0201 0.0275
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0046 0.0046
Loa Loa (eye worm) glutaminase 2 0.0271 0.053 0.2753
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Brugia malayi AKH receptor 0.0032 0.0046 0.0231
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0022 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0079 0.04
Echinococcus granulosus carbonic anhydrase 0.0058 0.01 0.01
Brugia malayi Cathepsin L-like precursor 0.0017 0.0015 0.007
Echinococcus granulosus GPCR family 2 0.0048 0.0079 0.0079
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0079 0.04
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.0271 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0007 0.0007
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0058 0.01 0.051
Loa Loa (eye worm) acetyltransferase 0.0167 0.032 0.1657
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.2813
Brugia malayi ORL1-like opioid receptor 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Treponema pallidum recombinase A 0.0107 0.0198 0.2591
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0058 0.0102
Onchocerca volvulus 0.0032 0.0046 0.0472
Echinococcus granulosus kelch ECH associated protein 1 like 0.0187 0.0361 0.0361
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0305 1
Schistosoma mansoni DNA ligase IV 0.001 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0087 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0015 0.0638
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0191 0.0987
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Onchocerca volvulus 0.0032 0.0046 0.0472
Echinococcus multilocularis zinc finger protein 0.0025 0.0031 0.0031
Schistosoma mansoni zinc finger protein 0.0015 0.0011 0.0011
Schistosoma mansoni coup transcription factor 0.001 0.0002 0.0002
Trypanosoma brucei protein kinase, putative 0.0052 0.0087 0.4284
Echinococcus multilocularis lamin dm0 0.0026 0.0035 0.0035
Brugia malayi hypothetical protein 0.001 0.0002 0.0004
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0033 0.0408
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Onchocerca volvulus 0.006 0.0104 0.1084
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0087 0.0087
Loa Loa (eye worm) cysteine protease 0.0017 0.0015 0.0072
Schistosoma mansoni neuropeptide receptor 0.0032 0.0046 0.0046
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.0194 0.0194
Onchocerca volvulus 0.0032 0.0046 0.0472
Plasmodium vivax vivapain-2 0.0017 0.0015 0.0418
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0022 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0002 0.0002
Onchocerca volvulus 0.0026 0.0035 0.0353
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0014 0.0384
Entamoeba histolytica hypothetical protein 0.0143 0.0271 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0058 0.01 0.0512
Loa Loa (eye worm) hypothetical protein 0.0101 0.0187 0.0966
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0046 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0002
Loa Loa (eye worm) ctsf protein 0.0017 0.0015 0.0072
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.01 0.051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0087 0.4284
Brugia malayi hypothetical protein 0.002 0.0022 0.0108
Onchocerca volvulus 0.0017 0.0015 0.0142
Onchocerca volvulus 0.0017 0.0015 0.0142
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.0827 0.4298
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Trypanosoma brucei ISWI complex protein 0.0015 0.0011 0.0453
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 0.0552
Onchocerca volvulus 0.0032 0.0046 0.0472
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0046 0.0046
Onchocerca volvulus 0.0032 0.0046 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0201 0.6549
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0145
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.01 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0507 0.101 0.101
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0035 0.1659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Mycobacterium tuberculosis Conserved protein 0.0108 0.0201 0.0275
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0002 0.0000017996
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0046 0.0046
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0014 0.0384
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0046 0.0046
Schistosoma mansoni cpg binding protein 0.0028 0.0039 0.0039
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0586
Brugia malayi beta-lactamase 0.0108 0.0201 0.1035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0107 0.0107
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0046 0.0231
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0093 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0137 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0174
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0187 0.0187
Brugia malayi Bromodomain containing protein 0.0041 0.0065 0.0328
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0046 0.0231
Schistosoma mansoni ferritin 0.0026 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0015 0.0072
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0195 0.0377 0.1956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0071 0.8115
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Onchocerca volvulus 0.0028 0.0039 0.0392
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0022 0.0659
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0046 0.0231
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.001 0.0044
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0201 0.0361
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0048 0.2303
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni hypothetical protein 0.0032 0.0046 0.0046
Schistosoma mansoni rab6-interacting 0.002 0.0022 0.0022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2438 0.4924 0.4924
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0015 0.0472
Onchocerca volvulus 0.0032 0.0046 0.0472
Schistosoma mansoni bromodomain containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0402
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni carbonic anhydrase 0.0058 0.01 0.01
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.0032 0.0046 0.0046
Loa Loa (eye worm) voltage-dependent calcium channel 0.0017 0.0016 0.0075
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0046 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0032 0.0046 0.0046
Brugia malayi DKFZp564C0469 protein 0.001 0.0002 0.0004
Onchocerca volvulus 0.0032 0.0046 0.0472
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0019 0.0612
Schistosoma mansoni topbp1 0.001 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0035 0.0173
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0087 0.4284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Schistosoma mansoni hypothetical protein 0.0104 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0201 0.2105
Onchocerca volvulus Huntingtin homolog 0.0119 0.0223 0.2344
Onchocerca volvulus 0.0108 0.0201 0.2112
Brugia malayi hypothetical protein 0.0119 0.0223 0.115
Leishmania major cathepsin L-like protease 0.0017 0.0015 0.0194
Schistosoma mansoni hypothetical protein 0.0188 0.0363 0.0363
Onchocerca volvulus 0.001 0.0002 0.0008
Schistosoma mansoni amine GPCR 0.0032 0.0046 0.0046
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.0592
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0046 0.0046
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0383 0.0757 0.1377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0046 0.0046
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0033 0.0408
Plasmodium falciparum carbonic anhydrase 0.0058 0.01 0.3211
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0022 0.0659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0035 0.0175
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0002 0.0002
Brugia malayi Serotonin receptor 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.016 0.0305 0.1581
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.000005599
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0015 0.0015
Schistosoma mansoni biogenic amine receptor 0.0032 0.0046 0.0046
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0000063207
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0046 0.0046
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0014
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Onchocerca volvulus 0.0024 0.0029 0.0291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0046 0.0046
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0019 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0046 0.0046
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.0827
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0084 0.27
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0014
Brugia malayi Cathepsin L-like precursor 0.0017 0.0015 0.007
Schistosoma mansoni amine GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0046 0.0046
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0058 0.01 0.4903
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.011 0.5418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0002
Trypanosoma cruzi ISWI complex protein 0.0015 0.0011 0.0453
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0015 0.0472
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0046 0.0231
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0012
Schistosoma mansoni biogenic amine receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0019 0.0827
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0087 0.4284
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0087 0.4284
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0046 0.0234
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Onchocerca volvulus 0.0017 0.0015 0.0142
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0087 0.0448
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.1382 0.202
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0201 0.1038
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0015 0.0072
Echinococcus multilocularis kelch ECH associated protein 1 0.0187 0.0361 0.0361
Toxoplasma gondii hypothetical protein 0.0055 0.0093 0.2989
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0082
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0015 0.0015
Onchocerca volvulus 0.0032 0.0046 0.0472
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0046 0.0046
Brugia malayi hypothetical protein 0.0958 0.1924 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0201 0.0275
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0586
Schistosoma mansoni myosin xvIII 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0201 0.0275
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0046 0.0234
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0019 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0079 0.0402
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.1659
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0058 0.0058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0087 0.0087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0096 0.0096
Schistosoma mansoni microtubule-associated protein tau 0.4941 1 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.032 0.032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis expressed protein 0.0026 0.0033 0.0033
Onchocerca volvulus 0.0154 0.0294 0.3103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0029 0.0049
Echinococcus granulosus zinc finger protein 0.0025 0.0031 0.0031
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0015 0.0015
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0015 0.0015
Echinococcus multilocularis carbonic anhydrase 0.0058 0.01 0.01
Echinococcus multilocularis survival motor neuron protein 1 0.0958 0.1924 0.1924
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus multilocularis carbonic anhydrase 0.0058 0.01 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0137 0.0137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0029 0.0049
Echinococcus granulosus fmrfamide receptor 0.0032 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0048 0.0079 0.0079
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Onchocerca volvulus 0.0032 0.0046 0.0472
Entamoeba histolytica hypothetical protein 0.0143 0.0271 1
Echinococcus granulosus tumor protein p63 0.0692 0.1385 0.1385
Brugia malayi isocitrate dehydrogenase 0.0016 0.0014 0.0065
Mycobacterium ulcerans transcriptional regulator 0.2715 0.5487 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0201 0.1038
Onchocerca volvulus 0.0026 0.0035 0.0353
Trypanosoma cruzi ISWI complex protein 0.0015 0.0011 0.0453
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0046 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.0271 0.0271
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0081 0.0145 0.0145
Echinococcus granulosus g protein coupled receptor 0.0032 0.0046 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0029 0.0935
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0201 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) hypothetical protein 0.0077 0.0137 0.0708
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0046 0.0046
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0082 0.403
Brugia malayi Pre-SET motif family protein 0.006 0.0104 0.0531
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0099 0.4855
Schistosoma mansoni hypothetical protein 0.0195 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0048 0.0079 0.0079
Brugia malayi G protein-coupled receptor 0.0032 0.0046 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0201 1
Trichomonas vaginalis glutaminase, putative 0.0271 0.053 0.5607
Brugia malayi beta-lactamase family protein 0.0108 0.0201 0.1035
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.005 0.0053
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0058 0.01 0.3211
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0081 0.0145 0.0145
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Brugia malayi topoisomerase 0.001 0.0002 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0078 0.014 0.072
Echinococcus granulosus g protein coupled receptor 0.0032 0.0046 0.0046
Onchocerca volvulus 0.0108 0.0201 0.2112
Schistosoma mansoni survival motor neuron protein 0.0195 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0154 0.0294 0.1524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) hypothetical protein 0.0104 0.0191 0.0989
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0071 0.257
Schistosoma mansoni rab6-interacting 0.002 0.0022 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0104 0.0104
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0058 0.01 0.051
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0015 0.0015
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0015 0.0015
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0305 1
Leishmania major hypothetical protein, conserved 0.0108 0.0201 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0029 0.0049
Onchocerca volvulus 0.0032 0.0046 0.0472
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0015 0.007
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.01 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0002 0.0004
Loa Loa (eye worm) carbonic anhydrase 3 0.0058 0.01 0.0512
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0019 0.0392
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0087 0.2806
Leishmania major cathepsin L-like protease 0.0063 0.011 0.52
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0017 0.0015 0.0194
Echinococcus granulosus carbonic anhydrase II 0.0058 0.01 0.01
Brugia malayi Cathepsin L-like precursor 0.0017 0.0015 0.007
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2715 0.5487 1
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0019
Schistosoma mansoni biogenic amine receptor 0.0032 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0058 0.0058
Trichomonas vaginalis ferritin, putative 0.0026 0.0033 0.0327
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0033 0.0056
Chlamydia trachomatis replicative DNA helicase 0.0383 0.0757 1
Echinococcus granulosus hypothetical protein 0.0032 0.0046 0.0046
Echinococcus multilocularis microtubule associated protein 2 0.4941 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Onchocerca volvulus 0.0017 0.0015 0.0142
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0145
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni bromodomain containing protein 0.0067 0.0117 0.0117
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0151 0.0288 0.1495
Echinococcus multilocularis cysteine protease 0.0017 0.0015 0.0015
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0014 0.0065
Echinococcus granulosus replication factor c subunit 1 0.001 0.0002 0.0002
Echinococcus multilocularis kelch ECH associated protein 1 0.0187 0.0361 0.0361
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0046 0.0231
Schistosoma mansoni ferritin light chain 0.0026 0.0033 0.0033
Echinococcus granulosus neuropeptide receptor 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0058 0.01 0.0512
Onchocerca volvulus 0.0108 0.0201 0.2112
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0087 0.4013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Onchocerca volvulus 0.0475 0.0944 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0017 0.0004
Echinococcus granulosus carbonic anhydrase 0.0058 0.01 0.01
Brugia malayi Dopamine receptor 0.0032 0.0046 0.0231
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.0194 0.0265
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0046 0.0234
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0058 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0046 0.0046
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0046 0.0046
Echinococcus multilocularis voltage dependent calcium channel 0.0081 0.0145 0.0145
Onchocerca volvulus 0.0032 0.0046 0.0472
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0002 0.0002
Mycobacterium ulcerans recombinase A 0.0107 0.0198 0.0357
Schistosoma mansoni peptidase Clp (S14 family) 0.016 0.0305 0.0305
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0014
Brugia malayi Probable ClpP-like protease 0.016 0.0305 0.1579
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0046 0.0046
Brugia malayi Inositol-1 0.0038 0.0058 0.0294
Loa Loa (eye worm) hypothetical protein 0.0089 0.0161 0.0832
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0014 0.0586
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0081 0.0145 0.0746
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Schistosoma mansoni amine GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0046 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0029 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Toxoplasma gondii cathepsin CPL 0.0017 0.0015 0.0418
Onchocerca volvulus 0.0032 0.0046 0.0472
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0046 0.0046
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0046 0.0234
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.014
Schistosoma mansoni hypothetical protein 0.0058 0.01 0.01
Brugia malayi larval opioid receptor 0.0032 0.0046 0.0231
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0174
Echinococcus granulosus intermediate filament protein 0.0026 0.0035 0.0035
Onchocerca volvulus 0.002 0.0022 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Brugia malayi hypothetical protein 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0014
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0093 0.2989
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2715 0.5487 0.8079
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0143 0.0271 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0002 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0542
Schistosoma mansoni opsin-like receptor 0.0032 0.0046 0.0046
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0072
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.0015
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0029 0.0029
Echinococcus granulosus survival motor neuron protein 1 0.0958 0.1924 0.1924
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0107 0.0198 0.2591
Schistosoma mansoni ferritin light chain 0.0026 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0046 0.0046
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0137 0.0137
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0079 0.0079
Toxoplasma gondii hypothetical protein 0.0089 0.0161 0.5245
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0017 0.0482
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0068 0.012 0.0619
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0002 0.0002
Trypanosoma brucei carbonic anhydrase-like protein 0.0058 0.01 0.4903
Schistosoma mansoni ferritin 0.0026 0.0033 0.0033
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.01 0.051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0175
Echinococcus multilocularis RUN 0.002 0.0022 0.0022
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.2813
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0015 0.0142
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0201 0.0201
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0016 0.0016
Schistosoma mansoni lipoxygenase 0.002 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0201 0.0275
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.2813
Echinococcus granulosus allatostatin A receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis ferritin 0.0026 0.0033 0.0033
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0087 0.0087
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0201 0.1038
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0046 0.0046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.0017 0.0015 0.0194
Loa Loa (eye worm) calcium channel 0.0081 0.0145 0.0748
Schistosoma mansoni hypothetical protein 0.0143 0.0271 0.0271
Leishmania major cathepsin L-like protease 0.0017 0.0015 0.0194
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0288 0.1495
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0014 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0902
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Loa Loa (eye worm) hypothetical protein 0.0958 0.1924 1
Trichomonas vaginalis set domain proteins, putative 0.0475 0.0944 1
Entamoeba histolytica hypothetical protein 0.0143 0.0271 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Schistosoma mansoni hypothetical protein 0.0048 0.0079 0.0079
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0288 0.1493
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0063 0.011 0.52
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0201 0.2105
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0019 0.0217
Echinococcus multilocularis Kelch repeat type 1 0.0188 0.0363 0.0363
Brugia malayi hypothetical protein 0.0143 0.0271 0.1399
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0019 0.0217
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0081 0.0145 0.0145
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0046 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.0271 0.0271
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.0194 0.0265
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0029 0.0995
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0079 0.0079
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0096 0.0096
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0201 0.2105
Treponema pallidum replicative DNA helicase (dnaB) 0.0383 0.0757 1
Schistosoma mansoni hypothetical protein 0.0032 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0093 0.1198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.032 0.1655
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0082
Onchocerca volvulus 0.0017 0.0015 0.0142
Schistosoma mansoni lamin 0.0026 0.0035 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0046 0.0046
Brugia malayi RE15519p 0.0032 0.0046 0.0231
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0052 0.0052
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.011 0.5418
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0107 0.0198 0.0357
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0022 0.0022
Brugia malayi CXXC zinc finger family protein 0.0028 0.0039 0.0192
Leishmania major carbonic anhydrase-like protein 0.0058 0.01 0.4662
Onchocerca volvulus Huntingtin homolog 0.0119 0.0223 0.2344
Brugia malayi G-protein coupled receptor 0.0032 0.0046 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Brugia malayi GnHR receptor homolog 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0089 0.0161 0.0832
Plasmodium vivax SET domain protein, putative 0.006 0.0104 0.3348
Schistosoma mansoni zinc finger protein 0.0025 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0015 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0082
Echinococcus granulosus cpg binding protein 0.0032 0.0046 0.0046
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0000017996
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0046 0.0046
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0104 0.3348
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0046 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0002
Echinococcus multilocularis tumor protein p63 0.0692 0.1385 0.1385
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0022 0.0022
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0383 0.0757 0.1377
Echinococcus multilocularis nibrin 0.001 0.0002 0.0002
Loa Loa (eye worm) doublecortin family protein 0.002 0.0022 0.011
Brugia malayi hypothetical protein 0.0017 0.0016 0.0076
Brugia malayi hypothetical protein 0.0154 0.0294 0.1522
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0084 0.0868
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0084 0.0868
Schistosoma mansoni apoferritin-2 0.0026 0.0033 0.0033
Toxoplasma gondii hypothetical protein 0.0015 0.0011 0.0299
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0014 0.0014
Schistosoma mansoni cpg binding protein 0.0032 0.0046 0.0046
Echinococcus multilocularis musashi 0.0026 0.0035 0.0035
Echinococcus granulosus expressed protein 0.0026 0.0033 0.0033
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.0194 0.0348
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0046 0.0231
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.016 0.0305 0.0305
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0046 0.0046
Brugia malayi Dopamine receptor protein 1 0.0032 0.0046 0.0231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0108 0.0201 0.1038
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0084 0.27
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0201 0.0275
Echinococcus granulosus geminin 0.0507 0.101 0.101
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 0.0552
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Brugia malayi Pre-SET motif family protein 0.0417 0.0827 0.4296
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0081 0.0145 0.0145
Schistosoma mansoni neuropeptide receptor 0.0032 0.0046 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0029 0.0049
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0035 0.1086
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0234
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0046 0.0234
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0071 0.2277
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0046 0.0046
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0046 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0002 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0015 0.0142
Schistosoma mansoni opsin-like receptor 0.0032 0.0046 0.0046
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0007 0.0028
Brugia malayi hypothetical protein 0.002 0.0022 0.0108
Mycobacterium ulcerans hypothetical protein 0.0108 0.0201 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0134
Mycobacterium ulcerans TetR family transcriptional regulator 0.2715 0.5487 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0046 0.0046
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0046 0.0046
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0046 0.0472
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0014 0.0586
Echinococcus multilocularis carbonic anhydrase 0.0058 0.01 0.01
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3081 0.6229 0.9174
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0046 0.0046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0017 0.0027
Echinococcus multilocularis serotonin receptor 0.0032 0.0046 0.0046
Mycobacterium ulcerans glutaminase 0.0271 0.053 0.0963
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0029 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0145
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0004 0.0056
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0014 0.0384
Brugia malayi sulfakinin receptor protein 0.0032 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0289
Loa Loa (eye worm) beta-lactamase 0.0108 0.0201 0.1038
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.016 0.0305 0.4008
Schistosoma mansoni apoferritin-2 0.0026 0.0033 0.0033
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0046 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0002
Brugia malayi PHD-finger family protein 0.003 0.0042 0.0208

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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