Detailed information for compound 585719

Basic information

Technical information
  • TDR Targets ID: 585719
  • Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl- 1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5- (trifluoromethyl)hexyl]-2,3,3a,5,6,7-hexahydr o-1H-inden-4-ylidene]ethylidene]-4-methylene- cyclohexane-1,3-diol
  • MW: 524.579 | Formula: C27H38F6O3
  • H donors: 3 H acceptors: 3 LogP: 6.56 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](CCCC(C(F)(F)F)(C(F)(F)F)O)C)C)/C1
  • InChi: 1S/C27H38F6O3/c1-16(6-4-13-25(36,26(28,29)30)27(31,32)33)21-10-11-22-18(7-5-12-24(21,22)3)8-9-19-14-20(34)15-23(35)17(19)2/h8-9,16,20-23,34-36H,2,4-7,10-15H2,1,3H3/b18-8+,19-9-/t16-,20-,21-,22+,23+,24-/m1/s1
  • InChiKey: XPYGGHVSFMUHLH-UUSULHAXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylenecyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3
  • 83805-11-2
  • (5Z,7E)-(1S,3R)-26,26,26,27,27,27-hexafluoro-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol
  • 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxyvitamin D3 / 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol
  • LMST03020089
  • D01662
  • Falecalcitoriol
  • Falecalcitoriol (JAN)
  • Hornel
  • Hornel (TN)
  • (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta,25-triol
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1-alpha,3-beta,5Z,7E)-
  • Falecalcitriol
  • Falecalcitriol [INN]
  • Flocalcitriol
  • Hornel, Fulstan
  • Ro 23-4194
  • ST 630
  • DSC-103
  • Fulstan
  • Hexafluorocalcitriol
  • Horner
  • Ro-23-4194
  • ST-630

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis muscleblind protein 0.0145 0.0522 0.0577
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0052 0.0109 0.6784
Echinococcus granulosus histone acetyltransferase KAT2B 0.0177 0.0666 0.0736
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Brugia malayi hypothetical protein 0.0035 0.0029 0.0115
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Schistosoma mansoni hypothetical protein 0.0035 0.0032 0.0035
Toxoplasma gondii hypothetical protein 0.0086 0.0261 0.0353
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0121 0.0134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus serotonin receptor 0.0055 0.0121 0.0134
Toxoplasma gondii microneme protein MIC4 0.0032 0.002 0.0027
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.0463 0.1805
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0121 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0261 0.3615
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0035 0.0032 0.0321
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0035 0.0032 0.0321
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0121 0.0473
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0029 0.0115
Plasmodium vivax aspartyl protease, putative 0.0035 0.0029 0.0441
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0035 0.0032 0.0008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0327
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0682
Onchocerca volvulus 0.0055 0.0121 0.0551
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0086 0.0261 0.0288
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0121 0.0473
Schistosoma mansoni microtubule-associated protein tau 0.2053 0.9046 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.0463 0.6652
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0035 0.0032 0.0061
Onchocerca volvulus 0.0443 0.1854 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0478 0.0528
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0177 0.0666 1
Onchocerca volvulus 0.0055 0.0121 0.0551
Onchocerca volvulus 0.0035 0.003 0.0052
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Onchocerca volvulus 0.0035 0.003 0.0052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0585 0.2489 0.2752
Loa Loa (eye worm) beta-lactamase 0.0035 0.0031 0.0081
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0035 0.0032 0.0061
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0031 0.0034
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0031 0.0034
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0086 0.0261 0.0288
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0035 0.0032 0.0008
Trypanosoma cruzi glycerol uptake protein, putative 0.0086 0.0261 0.3924
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0035 0.0032 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi cytochrome P450 0.0035 0.0032 0.0124
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0121 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0035 0.0032 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0121 0.0134
Toxoplasma gondii microneme protein, putative 0.0032 0.002 0.0027
Onchocerca volvulus 0.0056 0.0125 0.0572
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0032 0.002 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0121 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0035 0.0032 0.0008
Onchocerca volvulus 0.0055 0.0121 0.0551
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0029 0.0115
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0121 0.0317
Brugia malayi beta-lactamase 0.0035 0.0031 0.0121
Schistosoma mansoni biogenic amine receptor 0.0055 0.0121 0.0134
Brugia malayi Cytochrome P450 family protein 0.0035 0.0032 0.0124
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0121 0.0317
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0035 0.003 0.0052
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0478 0.0528
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0035 0.0032 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus somatostatin receptor 0.0055 0.0121 0.0134
Brugia malayi GnHR receptor homolog 0.0055 0.0121 0.0473
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0035 0.0032 0.0008
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.0463 0.0512
Toxoplasma gondii microneme protein MIC17C 0.0032 0.002 0.0027
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0035 0.0032 0.0061
Echinococcus granulosus allatostatin A receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis serotonin receptor 0.0055 0.0121 0.0134
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0121 0.0134
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0121 0.0134
Brugia malayi hypothetical protein 0.0035 0.0029 0.0115
Onchocerca volvulus 0.0055 0.0121 0.0551
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0177 0.0666 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Echinococcus multilocularis sex peptide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni myosin xvIII 0.0055 0.0121 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0086 0.0261 0.0288
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Brugia malayi neuropeptide F receptor 0.0055 0.0121 0.0473
Echinococcus multilocularis snurportin 1 0.0298 0.1208 0.1335
Plasmodium falciparum plasmepsin IX 0.0035 0.0029 0.049
Echinococcus multilocularis GPCR, family 2 0.0047 0.0085 0.0094
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0109 0.1541
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0011 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Brugia malayi Melatonin receptor type 1A 0.0055 0.0121 0.0473
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Leishmania major DNA polymerase eta, putative 0.0043 0.0069 0.0907
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0031 0.0031
Entamoeba histolytica hypothetical protein, conserved 0.0086 0.0261 0.1709
Mycobacterium leprae putative cytochrome p450 0.0035 0.0032 1
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0121 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0031 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0035 0.0032 0.0008
Trypanosoma brucei unspecified product 0.0187 0.0712 0.0712
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0463 0.7111
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0719 0.3089 0.3415
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0522 0.0577
Brugia malayi RE15519p 0.0055 0.0121 0.0473
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.0369 0.0967
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0064 0.0161 0.0178
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0443 0.1854 0.4851
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0121 0.0134
Schistosoma mansoni zinc finger protein 0.0086 0.0261 0.0288
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis dna polymerase eta 0.0043 0.0069 0.0076
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0035 0.0032 0.0008
Toxoplasma gondii PAN/Apple domain-containing protein 0.0032 0.002 0.0027
Trypanosoma brucei ribonuclease H1 0.0173 0.0647 0.0647
Brugia malayi beta-lactamase family protein 0.0035 0.0031 0.0121
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0121 0.0317
Onchocerca volvulus 0.0035 0.003 0.0052
Brugia malayi G-protein coupled receptor 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0121 0.0317
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0086 0.0261 0.1709
Onchocerca volvulus 0.0035 0.0029 0.005
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0086 0.0261 0.0288
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0121 0.0134
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0086 0.0261 0.1709
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0121 0.0134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0121 0.0134
Trypanosoma brucei glycerol uptake protein, putative 0.0086 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0181
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0121 0.0134
Schistosoma mansoni opsin-like receptor 0.0055 0.0121 0.0134
Schistosoma mansoni lozenge 0.0056 0.0123 0.0136
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0086 0.0261 0.0288
Trypanosoma cruzi glycerol uptake protein, putative 0.0086 0.0261 0.3924
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0035 0.0032 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0109 0.0286
Brugia malayi Cytochrome P450 family protein 0.0111 0.0369 0.1441
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0077
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Schistosoma mansoni hypothetical protein 0.0499 0.2104 0.2326
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0032 0.0035
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0086 0.0261 0.1709
Onchocerca volvulus 0.0035 0.0029 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0146 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni cathepsin D (A01 family) 0.0431 0.1799 0.1989
Brugia malayi Dopamine receptor protein 1 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0029 0.0115
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0035 0.0032 0.0061
Echinococcus multilocularis Protein lozenge 0.0056 0.0123 0.0136
Brugia malayi Cytochrome P450 family protein 0.0052 0.0109 0.0426
Leishmania major cytochrome p450-like protein 0.0035 0.0032 0.0321
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus microtubule associated protein 2 0.2053 0.9046 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0146 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0029 0.004
Echinococcus multilocularis microtubule associated protein 2 0.2053 0.9046 1
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0086 0.0261 0.0288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0121 0.0134
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0086 0.0261 0.0288
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0035 0.0032 0.0061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0121 0.0134
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0121 0.0134
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0035 0.0032 0.0008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0121 0.0134
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0146 0.2125
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0146 0.0162
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0035 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0145 0.0522 0.1366
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0086 0.0261 0.0288
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0463 0.7111
Brugia malayi putative neuropeptide receptor 0.0055 0.0121 0.0473
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0029 0.0077
Echinococcus granulosus neuropeptide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1208 0.3161
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0602 0.2565 0.2835
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi Serotonin receptor 0.0055 0.0121 0.0473
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0146 0.0198
Toxoplasma gondii microneme protein MIC17A 0.0032 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0682
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Toxoplasma gondii microneme protein MIC17B 0.0032 0.002 0.0027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0121 0.0317
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0121 0.0134
Trypanosoma brucei cytochrome P450, putative 0.0052 0.0109 0.0109
Entamoeba histolytica acetyltransferase, GNAT family 0.0162 0.06 1
Onchocerca volvulus 0.0055 0.0121 0.0551
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0035 0.0032 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0146 0.1373
Echinococcus multilocularis somatostatin receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0121 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0031 0.031
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0035 0.003 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0121 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0538 0.2096
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0177 0.0666 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0478 0.0528
Onchocerca volvulus Ribonuclease H1 homolog 0.0173 0.0647 0.3416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0478 0.0528
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Brugia malayi Hhat protein 0.0086 0.0261 0.1016
Trypanosoma brucei ingi protein (ORF1) 0.0187 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0121 0.0317
Loa Loa (eye worm) runx1 0.0056 0.0123 0.0323
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0121 0.0134
Treponema pallidum ribonuclease H (rnhA) 0.0173 0.0647 1
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Giardia lamblia Ribonuclease H 0.0173 0.0647 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0121 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0121 0.0134
Plasmodium vivax aspartyl protease, putative 0.0035 0.0029 0.0441
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0035 0.0032 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Toxoplasma gondii PAN domain-containing protein 0.0302 0.1225 0.1657
Echinococcus granulosus o acyltransferase membrane bound domain 0.0086 0.0261 0.0288
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0032 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0035 0.0032 0.0008
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0883 0.3821 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0077
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0035 0.0032 0.0061
Schistosoma mansoni opsin-like receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0146 0.0528 0.0583
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0031 0.0034
Echinococcus granulosus ribonuclease H1 0.0173 0.0647 0.0715
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0121 0.0134
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0086 0.0261 0.0353
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0035 0.0032 0.0061
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0035 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0398 0.1043
Onchocerca volvulus 0.0055 0.0121 0.0551
Schistosoma mansoni sterol O-acyltransferase 1 0.0883 0.3821 0.4225
Schistosoma mansoni hypothetical protein 0.0056 0.0125 0.0138
Loa Loa (eye worm) MBOAT family protein 0.0086 0.0261 0.0682
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0086 0.0261 0.0353
Toxoplasma gondii aspartyl protease 0.0035 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Leishmania major cytochrome p450-like protein 0.0035 0.0032 0.0321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.003 0.0115
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus sterol O acyltransferase 1 0.0883 0.3821 0.4225
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0146 0.0162
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0086 0.0261 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0086 0.0261 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0125 0.0327
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Toxoplasma gondii hypothetical protein 0.0032 0.002 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0121 0.0134
Toxoplasma gondii subtilisin SUB12 0.0032 0.002 0.0027
Schistosoma mansoni lipoxygenase 0.0118 0.0402 0.0444
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hhat protein 0.0086 0.0261 0.0682
Onchocerca volvulus 0.0035 0.003 0.0052
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.0917 0.24
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0121 0.0134
Plasmodium falciparum plasmepsin V 0.0035 0.0029 0.049
Brugia malayi Protein kinase domain containing protein 0.0056 0.0125 0.0488
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0121 0.0134
Trichomonas vaginalis porcupine, putative 0.0086 0.0261 0.3615
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0121 0.0134
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0035 0.003 0.0115
Echinococcus granulosus geminin 0.0499 0.2104 0.2326
Echinococcus granulosus g protein coupled receptor 0.0055 0.0121 0.0134
Echinococcus granulosus sex peptide receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0086 0.0261 0.0288
Echinococcus multilocularis tissue type plasminogen activator 0.0056 0.0125 0.0138
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.0463 0.0512
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0121 0.0134
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0085 0.033
Onchocerca volvulus 0.0055 0.0121 0.0551
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0121 0.0473
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0064 0.0161 0.0178
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0463 0.0463
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0121 0.0134
Leishmania major ribonuclease H1, putative 0.0173 0.0647 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0121 0.0134
Echinococcus granulosus o acyltransferase membrane bound domain 0.0086 0.0261 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni opsin-like receptor 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0035 0.0032 0.0061
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0121 0.0317
Toxoplasma gondii hypothetical protein 0.0032 0.002 0.0027
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0146 0.0528 0.0714
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0146 0.0528 0.1381
Plasmodium vivax aspartyl protease, putative 0.0035 0.0029 0.0441
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0035 0.0032 0.0008
Brugia malayi Pax transcription factor protein 2 0.0233 0.0917 0.3576
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0121 0.0134
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0121 0.0473
Loa Loa (eye worm) hhat protein 0.0086 0.0261 0.0682
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0086 0.0261 0.0288
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0069 0.0069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0116 0.0392 0.1528
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0064 0.0161 0.0178
Brugia malayi acetyltransferase, GNAT family protein 0.0602 0.2565 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.1854 0.4851
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0121 0.0473
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0191 0.0211
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Echinococcus multilocularis sterol O acyltransferase 1 0.0883 0.3821 0.4225
Onchocerca volvulus 0.0035 0.0031 0.0059
Onchocerca volvulus 0.0035 0.003 0.0052
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0086 0.0261 0.0682
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0121 0.0134
Brugia malayi neuropeptide F receptor 0.0055 0.0121 0.0473
Echinococcus multilocularis geminin 0.0499 0.2104 0.2326
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus g protein coupled receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0035 0.0032 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0871 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0086 0.0261 0.0288
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0398 0.1043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0031 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0146 0.0162
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0116 0.0392 0.0433
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0173 0.0647 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0077
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Echinococcus granulosus fmrfamide receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0029 0.0077
Echinococcus multilocularis serotonin receptor 0.0055 0.0121 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0121 0.0134
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni hypothetical protein 0.0298 0.1208 0.1335
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0538 0.2096
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0121 0.0473
Echinococcus granulosus muscleblind protein 0.0145 0.0522 0.0577
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0035 0.003 0.0077
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Brugia malayi RNase H family protein 0.0173 0.0647 0.2521
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0392 0.0433
Schistosoma mansoni cathepsin D (A01 family) 0.0431 0.1799 0.1989
Brugia malayi RNA, U transporter 1 0.0079 0.023 0.0898
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0121 0.0134
Schistosoma mansoni biogenic amine receptor 0.0055 0.0121 0.0134
Leishmania major hypothetical protein, conserved 0.0056 0.0125 0.1789
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0035 0.0032 0.0061
Echinococcus granulosus snurportin 1 0.0298 0.1208 0.1335
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0121 0.0134
Trypanosoma brucei glycerol uptake protein, putative 0.0086 0.0261 0.0261
Schistosoma mansoni lipoxygenase 0.0082 0.0243 0.0269
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0328 0.1279
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0121 0.0134
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0035 0.0032 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0261 0.3615
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.0712 0.0712
Trypanosoma cruzi GUP1, putative 0.0086 0.0261 0.3924
Brugia malayi larval opioid receptor 0.0055 0.0121 0.0473
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0148 0.0538 0.1407
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.0463 0.1212
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0121 0.0551
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0121 0.0134
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0055 0.0121 0.0551
Entamoeba histolytica vacuolar protein sorting 26 0.0086 0.0261 0.1709
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0035 0.0032 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Schistosoma mansoni DNA polymerase eta 0.0043 0.0069 0.0076
Trypanosoma cruzi GUP1, putative 0.0086 0.0261 0.3924
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0085 0.0222
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0085 0.0094
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.1682 0.7391 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0031 0.0121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0478 0.0528
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0035 0.0032 0.0008
Echinococcus multilocularis ribonuclease H1 0.0173 0.0647 0.0715
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0121 0.0317
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0121 0.0134
Brugia malayi hypothetical protein 0.0443 0.1854 0.7228
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0053
Entamoeba histolytica hypothetical protein 0.0086 0.0261 0.1709
Brugia malayi hypothetical protein 0.0055 0.0121 0.0473
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Onchocerca volvulus 0.0055 0.0121 0.0551
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0134
Schistosoma mansoni neuropeptide receptor 0.0055 0.0121 0.0134
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0035 0.0032 0.0061
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0032 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0086 0.0261 0.4342
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.003 0.0115
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0215 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Toxoplasma gondii aspartyl protease ASP1 0.0146 0.0528 0.0714
Brugia malayi MH2 domain containing protein 0.0117 0.0398 0.1554
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0121 0.0134
Echinococcus multilocularis 0.0035 0.0032 0.0035
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0086 0.0261 0.0288
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0121 0.0134
Brugia malayi sulfakinin receptor protein 0.0055 0.0121 0.0473
Brugia malayi Dopamine receptor protein 2 0.0055 0.0121 0.0473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0035 0.0031 0.0059
Plasmodium falciparum plasmepsin IV 0.0146 0.0528 0.8791
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0402 0.0444
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0121 0.0134
Schistosoma mansoni hypothetical protein 0.0648 0.2768 0.306
Echinococcus granulosus g protein coupled receptor 0.0055 0.0121 0.0134
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0121 0.0473
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0029 0.0033
Loa Loa (eye worm) MBOAT family protein 0.0086 0.0261 0.0682
Leishmania major hypothetical protein, conserved 0.0086 0.0261 0.3924
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0121 0.0134
Plasmodium falciparum plasmepsin II 0.0146 0.0528 0.8791
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0029 0.049
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0069 0.0907
Brugia malayi Dopamine receptor 0.0055 0.0121 0.0473
Schistosoma mansoni phosphoglucomutase 0.0173 0.0647 0.0715
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0215 0.0238
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0121 0.0134
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0086 0.0261 0.0288
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0035 0.0032 0.0061
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0029 0.0441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0032 0.0043
Onchocerca volvulus 0.0035 0.0031 0.0059
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0146 0.0528 0.1381
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0031 0.031
Plasmodium vivax plasmepsin IV, putative 0.0146 0.0528 0.7922
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0121 0.0134
Leishmania major cytochrome p450-like protein 0.0052 0.0109 0.1541
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0121 0.0134
Schistosoma mansoni hypothetical protein 0.0086 0.0261 0.0288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0121 0.0134
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0121 0.0134
Trichomonas vaginalis transmembrane protein nessy, putative 0.0086 0.0261 0.3615
Loa Loa (eye worm) hypothetical protein 0.0101 0.0328 0.0858
Brugia malayi Serotonin receptor 0.0055 0.0121 0.0473
Plasmodium falciparum plasmepsin III 0.0035 0.0029 0.049
Echinococcus granulosus hypothetical protein 0.0055 0.0121 0.0134
Schistosoma mansoni histamine h1 receptor 0.0055 0.0121 0.0134
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0032 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0086 0.0261 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0121 0.0134
Brugia malayi RNase H family protein 0.0173 0.0647 0.2521
Schistosoma mansoni phosphoglucomutase 0.0173 0.0647 0.0715
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Plasmodium falciparum plasmepsin X 0.0035 0.0029 0.049
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0109 0.1541
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0261 0.3615
Brugia malayi Cytochrome P450 family protein 0.0052 0.0109 0.0426
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0121 0.0551
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0085 0.033
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0086 0.0261 0.0288
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0402 0.0444
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0187 0.0712 0.0712
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0035 0.0032 0.0061
Echinococcus granulosus dna polymerase eta 0.0043 0.0069 0.0076
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0121 0.0134
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0121 0.0317
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0086 0.0261 0.0288
Toxoplasma gondii PAN domain-containing protein 0.0302 0.1225 0.1657
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0035 0.0032 0.0008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0116 0.0392 0.1025
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0121 0.0134
Brugia malayi AKH receptor 0.0055 0.0121 0.0473
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0146 0.0162
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0478 0.1251
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0121 0.0134
Toxoplasma gondii kringle domain-containing protein 0.0056 0.0125 0.0169
Plasmodium falciparum cysteine repeat modular protein 1 0.0056 0.0125 0.2083
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0146 0.0528 0.0583
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Onchocerca volvulus 0.0055 0.0121 0.0551
Schistosoma mansoni hypothetical protein 0.0071 0.0191 0.0211
Brugia malayi PAN domain containing protein 0.0032 0.002 0.0079
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0146 0.0528 0.0583
Loa Loa (eye worm) hypothetical protein 0.0145 0.0522 0.1366
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0086 0.0261 0.0682
Trypanosoma brucei ingi protein (ORF1) 0.0187 0.0712 0.0712
Onchocerca volvulus 0.0035 0.003 0.0052
Toxoplasma gondii ribonuclease HI protein 0.0173 0.0647 0.0875
Loa Loa (eye worm) cytochrome P450 0.0035 0.0032 0.0083
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0191 0.0211
Loa Loa (eye worm) acetyltransferase 0.0602 0.2565 0.6711
Brugia malayi G protein-coupled receptor 0.0055 0.0121 0.0473
Leishmania major glycerol uptake protein, putative 0.0086 0.0261 0.3924
Echinococcus granulosus tissue type plasminogen activator 0.0056 0.0125 0.0138
Trypanosoma cruzi glycerol uptake protein, putative 0.0086 0.0261 0.3924
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0035 0.0032 0.0061
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0121 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0035 0.0032 0.0008
Brugia malayi beta-lactamase family protein 0.0035 0.0031 0.0121
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0032 0.0032
Brugia malayi diacylglycerol acyltransferase 0.0086 0.0261 0.1016
Plasmodium falciparum plasmepsin I 0.0146 0.0528 0.8791
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0538 0.1407
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0064 0.0161 0.0178
Leishmania major hypothetical protein, conserved 0.0035 0.0031 0.031
Plasmodium falciparum plasmepsin VII 0.0035 0.0029 0.049
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0121 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0478 0.0528
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0035 0.0032 0.0061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0121 0.0134
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0121 0.0473
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0121 0.0473
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.0463 0.7111
Trichomonas vaginalis ribonuclease H1, putative 0.0173 0.0647 0.9693
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0035 0.0032 0.0008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0031 0.0081
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0121 0.0134
Schistosoma mansoni hypothetical protein 0.0499 0.2104 0.2326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0085 0.0094
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0056 0.0125 0.1877
Onchocerca volvulus 0.0086 0.0261 0.1311
Schistosoma mansoni hypothetical protein 0.0047 0.0085 0.0094
Toxoplasma gondii ABC1 family protein 0.0035 0.0031 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0085 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0081
Schistosoma mansoni phosphoglucomutase 0.0173 0.0647 0.0715
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0086 0.0261 0.3913
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0121 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0478 0.1864
Echinococcus granulosus o acyltransferase membrane bound domain 0.0086 0.0261 0.0288
Echinococcus granulosus orexin receptor type 2 0.0055 0.0121 0.0134
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0035 0.0032 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.343 0.3791
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0125 0.1789
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0317
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0069 0.0269
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0035 0.0032 0.0008
Brugia malayi RNase H family protein 0.0173 0.0647 0.2521
Echinococcus granulosus GPCR family 2 0.0047 0.0085 0.0094
Loa Loa (eye worm) MBOAT family protein 0.0086 0.0261 0.0682
Brugia malayi hypothetical protein 0.0071 0.0191 0.0743
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0602 0.2565 0.2835
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0109 0.0286
Schistosoma mansoni hypothetical protein 0.0101 0.0328 0.0363
Trypanosoma cruzi ribonuclease H1, putative 0.0173 0.0647 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0121 0.0134
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0085 0.0094
Loa Loa (eye worm) hypothetical protein 0.0797 0.3436 0.8991
Brugia malayi G-protein coupled receptor 0.0055 0.0121 0.0473
Schistosoma mansoni biogenic amine receptor 0.0055 0.0121 0.0134
Onchocerca volvulus 0.0233 0.0917 0.4892
Onchocerca volvulus 0.0055 0.0121 0.0551
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0191 0.0211
Schistosoma mansoni adenoreceptor 0.0055 0.0121 0.0134
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.0463 0.0512
Plasmodium vivax aspartyl proteinase, putative 0.0146 0.0528 0.7922
Brugia malayi ORL1-like opioid receptor 0.0055 0.0121 0.0473
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0177 0.0666 0.0901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0478 0.0528
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0121 0.0134
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0086 0.0261 0.0288
Trypanosoma cruzi ribonuclease H1, putative 0.0173 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0222
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0177 0.0666 0.0901
Plasmodium falciparum plasmepsin VI 0.0146 0.0528 0.8791
Schistosoma mansoni tumor necrosis factor receptor related 0.0064 0.0161 0.0178
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0719 0.3089 0.3415
Brugia malayi Pepsin A precursor 0.0035 0.0029 0.0115
Brugia malayi Muscleblind-like protein 0.0145 0.0522 0.2035
Onchocerca volvulus 0.0055 0.0121 0.0551
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Brugia malayi Kringle domain containing protein 0.0056 0.0125 0.0488
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0146 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0162 0.06 1
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0121 0.0317
Schistosoma mansoni cytochrome P450 0.0035 0.0032 0.0035
Plasmodium vivax plasmepsin V, putative 0.0035 0.0029 0.0441
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0146 0.0528 0.782
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.002 0.0053
Schistosoma mansoni amine GPCR 0.0055 0.0121 0.0134
Echinococcus granulosus neuropeptide receptor 0.0055 0.0121 0.0134
Toxoplasma gondii PAN domain-containing protein 0.0032 0.002 0.0027
Loa Loa (eye worm) CYP4Cod1 0.0052 0.0109 0.0286
Brugia malayi MBOAT family protein 0.0086 0.0261 0.1016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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