Detailed information for compound 589606

Basic information

Technical information
  • TDR Targets ID: 589606
  • Name: (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxyme thyl)tetrahydrofuran-3-ol
  • MW: 251.242 | Formula: C10H13N5O3
  • H donors: 3 H acceptors: 5 LogP: -0.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1ncnc2N
  • InChi: 1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
  • InChiKey: OLXZPDWKRNYJJZ-RRKCRQDMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-3-tetrahydrofuranol
  • (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • (2R,3S,5R)-5-adenin-9-yl-2-methylol-tetrahydrofuran-3-ol
  • 2'-deoxyadenosine
  • Deoxyadenosines
  • 2'-deoxyformycin A
  • 2'-deoxy-5'-adenosine monophosphate
  • (2R,3S,5R)-5-(6-amino-9-purinyl)-2-(hydroxymethyl)-3-tetrahydrofuranol
  • (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-methylol-tetrahydrofuran-3-ol
  • 40627-14-3
  • 958-09-8
  • 96893-70-8
  • 7005-15-4
  • NCGC00161970-01
  • Adenosine, 2'-deoxy- (6CI,7CI,8CI,9CI)
  • nchembio.2007.39-comp4
  • SBB003141
  • D-erythro-Pentitol, 1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-2-deoxy-, (R)-
  • ACon0_001347
  • (R)-1-C-(7-Amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-2-deoxy-D-erythro-pentitol
  • C00559
  • 2'-dA
  • 9-(2'-Deoxy-.beta.-D-erythro-pentofuranosyl)adenine
  • AIDS-021670
  • AIDS021670
  • ZINC01081581
  • STOCK1N-51172
  • 4-26-00-03589 (Beilstein Handbook Reference)
  • 9H-Purin-6-amine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
  • 9H-Purin-6-amine, 9-(2-deoxy-beta-D-ribofuranosyl)-
  • AI3-52383
  • BRN 0091015
  • CCRIS 1782
  • EINECS 213-488-7
  • NSC 141848
  • NSC 143510
  • NSC 83258
  • beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-
  • beta-D-erythro-Pentofuranoside, adenine-9 2-deoxy-
  • 3D1
  • 5-(6-AMINO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL
  • (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
  • 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine
  • 9-(2-deoxy-beta-D-ribofuranosyl)-9H-purin-6-amine
  • CHEBI:17256
  • 9-(2'-Deoxy-beta-D-erythro-pentofuranosyl)adenine
  • ADENOSINE-5'-(DITHIO)PHOSPHATE

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenylate cyclase type V Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Get druggable targets OG5_126919 All targets in OG5_126919
Echinococcus multilocularis adenylate cyclase 9 Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Adenylate cyclase type 2 homolog Get druggable targets OG5_126919 All targets in OG5_126919
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126919 All targets in OG5_126919
Echinococcus granulosus adenylate cyclase 9 Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Get druggable targets OG5_126919 All targets in OG5_126919
Loa Loa (eye worm) adenylyl cyclase 3 Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Adenylate cyclase type 3 homolog Get druggable targets OG5_126919 All targets in OG5_126919
Brugia malayi Adenylyl cyclase protein Get druggable targets OG5_126919 All targets in OG5_126919
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0005 0.0005
Schistosoma mansoni opsin-like receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0065 0.0065
Onchocerca volvulus 0.0171 0.0566 0.2654
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.037 0.1314 0.1314
Echinococcus granulosus serotonin receptor 0.0185 0.0621 0.0621
Trypanosoma brucei btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.015 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis serotonin receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis neuropeptide receptor A26 0.0185 0.0621 0.0621
Schistosoma mansoni transient receptor potential channel 0.0112 0.0345 0.0345
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Echinococcus multilocularis GPCR, family 2 0.022 0.0751 0.0751
Echinococcus multilocularis serotonin transporter 0.0302 0.106 0.106
Schistosoma mansoni receptor-type adenylate cyclase 0.0021 0.0005 0.0005
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0331 0.3407
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.0621 0.0621
Schistosoma mansoni voltage-gated ion channel 0.0112 0.0345 0.0345
Brugia malayi hypothetical protein 0.0103 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0024 0.0013 0.0024
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0238 0.0666
Schistosoma mansoni nAChR subunit 0.0171 0.0566 0.0566
Echinococcus multilocularis G-protein coupled receptor, putative 0.0185 0.0621 0.0621
Schistosoma mansoni receptor-type adenylate cyclase 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Loa Loa (eye worm) chloride channel protein 7 0.0024 0.0013 0.0013
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.0228 0.0784 0.0784
Trypanosoma brucei btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Onchocerca volvulus 0.0117 0.0363 0.1703
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0024 0.0013 0.0024
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Trypanosoma brucei GMP reductase 0.0954 0.3512 1
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0049 0.0049
Echinococcus granulosus H:Cl exchange transporter 7 0.0024 0.0013 0.0013
Giardia lamblia 1,4-alpha-glucan branching enzyme 0.0048 0.0105 0.3689
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0037 0.0065 0.0065
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0064 0.0624
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Echinococcus granulosus G protein coupled receptor 139 0.0185 0.0621 0.0621
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.037 0.1314 0.1314
Echinococcus multilocularis potassium voltage gated channel protein 0.0112 0.0345 0.0345
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0048 0.0105 0.0105
Brugia malayi Adenylyl cyclase protein 0.0111 0.0343 0.0343
Schistosoma mansoni hypothetical protein 0.0021 0.0005 0.0005
Echinococcus granulosus potassium voltage gated channel protein 0.268 1 1
Schistosoma mansoni hypothetical protein 0.011 0.0337 0.0337
Entamoeba histolytica hypothetical protein 0.011 0.0337 0.4944
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus sodium leak channel non selective protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Echinococcus multilocularis transient receptor potential cation channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) latrophilin receptor protein 2 0.022 0.0751 0.0751
Schistosoma mansoni voltage-gated potassium channel 0.0117 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0088 0.0088
Schistosoma mansoni vesicular amine transporter 0.0228 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Trypanosoma cruzi beta tubulin, putative 0.0022 0.0008 0.0009
Trichomonas vaginalis hypothetical protein 0.0022 0.0007 0.0026
Echinococcus multilocularis transient receptor potential cation channel 0.0112 0.0345 0.0345
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0302 0.0302
Schistosoma mansoni kinase 0.0048 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0117 0.0363 0.0363
Brugia malayi Cyclic-nucleotide gated cation channel 0.0112 0.0345 0.0345
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0112 0.0345 0.0345
Trypanosoma cruzi potassium voltage-gated channel 0.0117 0.0363 0.1022
Trypanosoma brucei btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Schistosoma mansoni sodium/chloride dependent transporter 0.0302 0.106 0.106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Toxoplasma gondii hypothetical protein 0.0112 0.0345 0.0971
Brugia malayi Cytochrome P450 family protein 0.0026 0.0022 0.0022
Onchocerca volvulus 0.0185 0.0621 0.2914
Echinococcus multilocularis glycine receptor subunit alpha 1 0.037 0.1314 0.1314
Echinococcus granulosus glycine receptor subunit beta 0.037 0.1314 0.1314
Brugia malayi Transient-receptor-potential like protein 0.0112 0.0345 0.0345
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.037 0.1314 0.1314
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0587 0.2131 0.2131
Echinococcus multilocularis neuropeptide FF receptor 2 0.0185 0.0621 0.0621
Schistosoma mansoni acetylcholine receptor subunit beta 0.0171 0.0566 0.0566
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.0802 0.0802
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Leishmania major CBS domain protein, conserved 0.0024 0.0013 0.0024
Echinococcus granulosus potassium voltage gated channel protein 0.0112 0.0345 0.0345
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.037 0.1314 0.1314
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0029 0.0032 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Brugia malayi intermediate filament protein 0.0033 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Brugia malayi hypothetical protein 0.011 0.0337 0.0337
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0185 0.0621 0.0621
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Plasmodium falciparum transporter, putative 0.0051 0.0117 0.033
Brugia malayi G-protein coupled receptor 0.0185 0.0621 0.0621
Echinococcus granulosus potassium voltage gated channel protein 0.0228 0.0784 0.0784
Echinococcus multilocularis glycine receptor subunit alpha 1 0.037 0.1314 0.1314
Echinococcus granulosus retinal guanylyl cyclase 2 0.0029 0.0032 0.0032
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0302 0.106 0.106
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0024 0.0013 0.0013
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0051 0.0117 0.0117
Schistosoma mansoni neurotransmitter gated ion channel 0.0171 0.0566 0.0566
Brugia malayi Peptidase family M1 containing protein 0.0106 0.0325 0.0325
Onchocerca volvulus 0.0062 0.0156 0.0734
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0031 0.0075
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Trypanosoma cruzi Aminopeptidase M1, putative 0.0106 0.0325 0.0913
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0035 0.0035
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0185 0.0621 0.0621
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.0621 0.0621
Onchocerca volvulus 0.0033 0.0047 0.0221
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0345 0.0345
Leishmania major extracellular receptor, putative 0.0033 0.0049 0.0126
Schistosoma mansoni amine GPCR 0.0185 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0021 0.0005 0.0005
Echinococcus multilocularis voltage dependent calcium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis voltage gated potassium channel 0.0112 0.0345 0.0345
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0065 0.0173
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0005 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Echinococcus granulosus muscleblind protein 0.015 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0695 0.2538 0.2538
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.037 0.1314 0.1314
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0112 0.0345 0.0345
Echinococcus multilocularis glycine receptor subunit beta 0.037 0.1314 0.1314
Brugia malayi Inositol-1 0.0037 0.0064 0.0064
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0277 0.0776
Onchocerca volvulus 0.0106 0.0325 0.1524
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Schistosoma mansoni serine/threonine RGC 0.0029 0.0032 0.0032
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0008 0.0008
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0171 0.0566 0.0566
Schistosoma mansoni tubulin subunit beta 0.0022 0.0008 0.0008
Echinococcus granulosus lamin dm0 0.0033 0.0047 0.0047
Brugia malayi mKIAA0176 protein 0.0117 0.0363 0.0363
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0112 0.0345 0.0345
Echinococcus multilocularis cpg binding protein 0.0091 0.0266 0.0266
Onchocerca volvulus 0.0021 0.0005 0.0021
Schistosoma mansoni adenylate cyclase 0.0021 0.0005 0.0005
Onchocerca volvulus Neuropeptide F receptor homolog 0.0185 0.0621 0.2914
Onchocerca volvulus 0.0185 0.0621 0.2914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Brugia malayi cation channel family protein 0.0112 0.0345 0.0345
Trichomonas vaginalis cyclin B, putative 0.0042 0.0083 0.0823
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0185 0.0621 0.0621
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0185 0.0621 0.0621
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0088 0.0238
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0025 0.0025
Echinococcus multilocularis aminopeptidase N 0.0188 0.0632 0.0632
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0185 0.0621 0.0621
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0185 0.0621 0.0621
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0238 0.0666
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0112 0.0345 0.0345
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Leishmania major hypothetical protein, conserved 0.0024 0.0013 0.0024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0322
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0302 0.0302
Toxoplasma gondii transporter, cation channel family protein 0.0112 0.0345 0.0971
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0049 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0112 0.0345 0.0345
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0008 0.0008
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0106 0.0325 0.0913
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0033 0.0049 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0095 0.0095
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0112 0.0345 0.0345
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0509 0.1839 0.1839
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0688 0.251 0.251
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0112 0.0345 0.0345
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.037 0.1314 0.1314
Echinococcus multilocularis integrin beta 2 0.0504 0.1821 0.1821
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Echinococcus multilocularis transient receptor potential cation channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0047 0.0047
Brugia malayi hypothetical protein 0.0168 0.0554 0.0554
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus g protein coupled receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0117
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.0621 0.0621
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0031 0.0075
Onchocerca volvulus 0.0509 0.1839 0.8629
Brugia malayi Serotonin receptor 0.0185 0.0621 0.0621
Schistosoma mansoni sodium-dependent amino acid transporter 0.0051 0.0117 0.0117
Brugia malayi ORL1-like opioid receptor 0.0185 0.0621 0.0621
Schistosoma mansoni ryanodine receptor related 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus multilocularis sodium channel protein 0.0227 0.0779 0.0779
Loa Loa (eye worm) LGC-31 protein 0.037 0.1314 0.1314
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.037 0.1314 0.1314
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0621 0.0621
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0954 0.3512 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.1057 0.3899 0.3899
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0111 0.0343 0.1611
Echinococcus granulosus sodium and chloride dependent glycine 0.0051 0.0117 0.0117
Brugia malayi Cation transporter family protein 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0339 0.1198 0.1198
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0117
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0024
Schistosoma mansoni hypothetical protein 0.022 0.0751 0.0751
Echinococcus granulosus tubulin subunit beta 0.0022 0.0008 0.0008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0185 0.0621 0.0621
Brugia malayi Bromodomain containing protein 0.0029 0.0035 0.0035
Echinococcus granulosus tubulin beta 4A class IVa 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Giardia lamblia Tenascin precursor 0.0022 0.0007 0.0092
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0029 0.0032 0.0032
Echinococcus granulosus transient receptor potential cation channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Echinococcus granulosus aminopeptidase N 0.0188 0.0632 0.0632
Giardia lamblia Kinase, PLK 0.0094 0.0277 1
Schistosoma mansoni hypothetical protein 0.022 0.0751 0.0751
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0065 0.0173
Onchocerca volvulus 0.0086 0.0248 0.1164
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.268 1 1
Leishmania major hypothetical protein, conserved 0.0117 0.0363 0.1022
Schistosoma mansoni neuropeptide receptor 0.0185 0.0621 0.0621
Leishmania major hypothetical protein, conserved 0.0112 0.0345 0.0971
Trichomonas vaginalis cyclins, putative 0.0029 0.0033 0.0299
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0286 0.0286
Mycobacterium ulcerans aminopeptidase N PepN 0.0106 0.0325 0.0913
Schistosoma mansoni voltage-gated cation channel 0.0112 0.0345 0.0345
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0954 0.3512 1
Trichomonas vaginalis cyclin B, putative 0.0042 0.0083 0.0823
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0033 0.0049 0.0049
Toxoplasma gondii CBS family protein 0.0024 0.0013 0.0024
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0069 0.0184 0.0184
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0112 0.0345 0.0345
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.022 0.0751 0.0751
Echinococcus granulosus beta tubulin 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0017
Plasmodium falciparum thioredoxin reductase 0.0037 0.0062 0.0168
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0065 0.0178
Brugia malayi ion channel NompC 0.0112 0.0345 0.0345
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0117 0.0363 0.1022
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0112 0.0345 0.0345
Onchocerca volvulus 0.0185 0.0621 0.2914
Brugia malayi jmjC domain containing protein 0.0096 0.0286 0.0286
Echinococcus granulosus orexin receptor type 2 0.0185 0.0621 0.0621
Mycobacterium tuberculosis Conserved protein 0.0043 0.0088 0.0238
Plasmodium falciparum phd finger protein, putative 0.0029 0.0035 0.0089
Schistosoma mansoni protein kinase 0.0184 0.0618 0.0618
Brugia malayi Melatonin receptor type 1A 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.005 0.0114 0.0114
Trypanosoma brucei Aminopeptidase M1, putative 0.0106 0.0325 0.0913
Loa Loa (eye worm) hypothetical protein 0.0218 0.0744 0.0744
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.0621 0.0621
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0969 0.2749
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0022 0.0008 0.0008
Brugia malayi CXXC zinc finger family protein 0.0086 0.0248 0.0248
Treponema pallidum sodium- and chloride- dependent transporter 0.0302 0.106 1
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0024 0.0013 0.0013
Onchocerca volvulus 0.0043 0.0088 0.0413
Schistosoma mansoni cpg binding protein 0.0086 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.0621 0.0621
Brugia malayi Peptidase family M1 containing protein 0.0188 0.0632 0.0632
Onchocerca volvulus 0.0218 0.0744 0.3493
Echinococcus multilocularis transient receptor potential gamma protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0033 0.0049 0.0049
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0621 0.0621
Onchocerca volvulus 0.01 0.0302 0.1417
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Echinococcus granulosus transient receptor potential cation channel 0.0112 0.0345 0.0345
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0931 0.3423 1
Onchocerca volvulus 0.0028 0.003 0.0139
Echinococcus multilocularis receptor type guanylyl cyclase 0.0184 0.0618 0.0618
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.037 0.1314 0.1314
Onchocerca volvulus 0.0037 0.0065 0.0306
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0022 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0149 0.0149
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Treponema pallidum Mg2+ transport protein (mgtE) 0.0024 0.0013 0.0079
Echinococcus granulosus glycine receptor subunit alpha 1 0.037 0.1314 0.1314
Brugia malayi GnHR receptor homolog 0.0185 0.0621 0.0621
Leishmania major trypanothione reductase 0.0037 0.0062 0.0164
Onchocerca volvulus 0.0033 0.0047 0.0221
Schistosoma mansoni adenoreceptor 0.0185 0.0621 0.0621
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0199 0.0673 0.0673
Echinococcus granulosus leukotriene A 4 hydrolase 0.0037 0.0065 0.0065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.022 0.0751 0.0751
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0112 0.0345 0.0971
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus tm gpcr rhodopsin 0.137 0.5076 0.5076
Onchocerca volvulus 0.037 0.1314 0.6167
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0117 0.0363 0.0363
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0322
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0302 0.0302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0041 0.0041
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0112 0.0345 0.0345
Echinococcus multilocularis transient receptor potential cation channel 0.0112 0.0345 0.0345
Brugia malayi K+ channel tetramerisation domain containing protein 0.0117 0.0363 0.0363
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0024 0.0013 0.0024
Brugia malayi Dopamine receptor protein 1 0.0185 0.0621 0.0621
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0435 0.1559 0.4431
Toxoplasma gondii IMP dehydrogenas 0.0954 0.3512 1
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0117 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0171 0.0566 0.0566
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0117 0.0363 0.1048
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0171 0.0566 0.2654
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0064 0.017
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0008 0.0008
Onchocerca volvulus 0.0043 0.0088 0.0413
Brugia malayi EGF-like domain containing protein 0.0022 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0112 0.0345 0.0345
Echinococcus granulosus adenylate cyclase 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0185 0.0621 0.2914
Onchocerca volvulus 0.0022 0.0007 0.0033
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0509 0.1839 0.1839
Brugia malayi glutathione reductase 0.0037 0.0062 0.0062
Trypanosoma brucei beta tubulin 0.0022 0.0008 0.0009
Toxoplasma gondii thioredoxin reductase 0.0037 0.0062 0.0164
Loa Loa (eye worm) tubulin beta chain 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Entamoeba histolytica alpha-amylase family protein 0.0108 0.0331 0.4856
Mycobacterium tuberculosis Probable reductase 0.0083 0.0238 0.0666
Loa Loa (eye worm) adenylyl cyclase 3 0.0111 0.0343 0.0343
Onchocerca volvulus 0.037 0.1314 0.6167
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0008 0.0008
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0031 0.0075
Mycobacterium tuberculosis 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) 0.0048 0.0105 0.0286
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0199 0.0673 0.0673
Giardia lamblia Tenascin-like 0.0022 0.0007 0.0092
Schistosoma mansoni adenylate cyclase 0.0021 0.0005 0.0005
Schistosoma mansoni starch branching enzyme II 0.0048 0.0105 0.0105
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0185 0.0621 0.0621
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0954 0.3512 0.3512
Brugia malayi Voltage gated chloride channel family protein 0.0024 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0117 0.0363 0.0363
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0112 0.0345 0.162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0088 0.0871
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.037 0.1314 0.1314
Echinococcus multilocularis calcium activated potassium channel 0.0112 0.0346 0.0346
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0954 0.3512 0.3512
Onchocerca volvulus 0.0509 0.1839 0.8629
Echinococcus granulosus transient receptor potential cation channel 0.0112 0.0345 0.0345
Entamoeba histolytica aminopeptidase, putative 0.0106 0.0325 0.4763
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Trypanosoma cruzi chloride channel protein, putative 0.0024 0.0013 0.0024
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0062 0.0168
Echinococcus multilocularis dro:myosuppressin receptor 0.0185 0.0621 0.0621
Brugia malayi Guanylyl cyclase protein 23 0.0062 0.0156 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.0621 0.0621
Schistosoma mansoni edp1-related 0.0117 0.0363 0.0363
Toxoplasma gondii beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0112 0.0345 0.0345
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0117 0.0363 0.1022
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0117 0.0363 0.0363
Echinococcus multilocularis adenylate cyclase 9 0.0111 0.0343 0.0343
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0587 0.2131 0.2131
Onchocerca volvulus 0.0024 0.0013 0.0061
Echinococcus multilocularis tyrosine kinase 0.004 0.0076 0.0076
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0024
Schistosoma mansoni tyrosine kinase 0.004 0.0076 0.0076
Schistosoma mansoni biogenic amine receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis sodium and chloride dependent glycine 0.0051 0.0117 0.0117
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0049 0.0049
Onchocerca volvulus 0.0199 0.0673 0.3159
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Entamoeba histolytica alpha-amylase family protein 0.0108 0.0331 0.4856
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0029 0.0032 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0149 0.0412
Trypanosoma cruzi GMP reductase 0.0954 0.3512 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) ryanodine receptor 0.0112 0.0345 0.0345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1057 0.3899 0.3899
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0227 0.0779 0.2209
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.037 0.1314 0.1314
Echinococcus multilocularis glycine receptor subunit beta 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) tubulin beta-2A chain 0.0022 0.0008 0.0008
Brugia malayi hypothetical protein 0.0171 0.0566 0.0566
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0171 0.0566 0.0566
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0931 0.3423 0.9748
Loa Loa (eye worm) chloride channel 3 0.0024 0.0013 0.0013
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Echinococcus multilocularis nAChR subunit 0.0199 0.0673 0.0673
Giardia lamblia High cysteine protein 0.0022 0.0007 0.0092
Brugia malayi beta-tubulin, identical 0.0022 0.0008 0.0008
Onchocerca volvulus 0.0185 0.0621 0.2914
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0024 0.0013 0.0024
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0035 0.0035
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0031 0.0075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.0621 0.0621
Entamoeba histolytica cyclin, putative 0.0042 0.0083 0.1137
Echinococcus multilocularis G protein coupled receptor 139 0.1136 0.4195 0.4195
Brugia malayi GMP reductase 0.0411 0.147 0.147
Echinococcus granulosus short transient receptor potential channel 6 0.0112 0.0345 0.0345
Giardia lamblia Neurogenic locus Notch protein precursor 0.0022 0.0007 0.0092
Echinococcus multilocularis fibrillin 2 0.0022 0.0007 0.0007
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Trichomonas vaginalis esterase, putative 0.0043 0.0088 0.0871
Echinococcus granulosus hypothetical protein 0.0185 0.0621 0.0621
Brugia malayi glutaminase DH11.1 0.0276 0.0963 0.0963
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0088 0.0238
Mycobacterium tuberculosis Conserved protein 0.0024 0.0013 0.0024
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0117
Brugia malayi ancient conserved domain protein 2 0.0024 0.0013 0.0013
Toxoplasma gondii hypothetical protein 0.0051 0.0117 0.0322
Schistosoma mansoni cyclin B 0.0042 0.0083 0.0083
Schistosoma mansoni lamin 0.0033 0.0047 0.0047
Echinococcus granulosus transient receptor potential cation channel 0.0112 0.0345 0.0345
Echinococcus multilocularis hyperpolarization activated cyclic 0.0112 0.0345 0.0345
Echinococcus granulosus nAChR subunit 0.037 0.1314 0.1314
Brugia malayi PHD-finger family protein 0.0029 0.0035 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0099 0.0985
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0106 0.0325 0.0913
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.037 0.1314 0.1314
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0024 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0112 0.0345 0.0345
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0273 0.0765
Loa Loa (eye worm) hypothetical protein 0.0228 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0112 0.0345 0.0345
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0248 0.0248
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0024 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0112 0.0345 0.0345
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0112 0.0345 0.0345
Leishmania major hypothetical protein, conserved 0.0117 0.0363 0.1022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0185 0.0621 0.0621
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0033 0.0049 0.0049
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0083 0.0083
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0065 0.0065
Echinococcus multilocularis fibrillin 1 0.0022 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0088 0.0238
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0112 0.0345 0.0345
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0331 0.3407
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) melatonin receptor type 1A 0.0185 0.0621 0.0621
Schistosoma mansoni transient receptor potential channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.037 0.1314 0.1314
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0184 0.0618 0.2898
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0149 0.0412
Schistosoma mansoni hypothetical protein 0.0185 0.0621 0.0621
Giardia lamblia Tenascin-X 0.0022 0.0007 0.0092
Toxoplasma gondii hypothetical protein 0.0051 0.0117 0.0322
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0171 0.0566 0.0566
Onchocerca volvulus 0.0111 0.0343 0.1611
Onchocerca volvulus 0.0185 0.0621 0.2914
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0048 0.0105 0.0286
Brugia malayi EGF-like domain containing protein 0.0022 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0088 0.0238
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0171 0.0566 0.0566
Schistosoma mansoni chloride channel protein 0.0024 0.0013 0.0013
Trichomonas vaginalis tubulin alpha chain, putative 0.0022 0.0008 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0228 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0082 0.0232 0.0232
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0049 0.0049
Trypanosoma brucei beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus shaker cognate 0.0228 0.0784 0.0784
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0228 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus integrin beta 2 0.0504 0.1821 0.1821
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.0621 0.0621
Schistosoma mansoni neuropeptide receptor 0.0185 0.0621 0.0621
Brugia malayi Protein kinase domain containing protein 0.0688 0.2511 0.2511
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0024 0.0013 0.0013
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0587 0.2131 0.2131
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0363 0.1022
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.037 0.1314 0.1314
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Echinococcus granulosus potassium voltage gated channel protein 0.0228 0.0784 0.0784
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0088 0.0088
Brugia malayi follicle stimulating hormone receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis shaker cognate 0.0228 0.0784 0.0784
Trichomonas vaginalis cyclins, putative 0.0042 0.0083 0.0823
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0088 0.0238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0006 0.0003
Echinococcus granulosus voltage dependent calcium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0129 0.0129
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.037 0.1314 0.1314
Brugia malayi solute carrier family 40, member 1 0.0218 0.0744 0.0744
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0112 0.0345 0.162
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0031 0.0075
Schistosoma mansoni tyrosine kinase 0.004 0.0076 0.0076
Loa Loa (eye worm) voltage-gated calcium channel 0.0112 0.0345 0.0345
Brugia malayi Latrophilin receptor protein 2 0.022 0.0751 0.0751
Echinococcus granulosus fmrfamide receptor 0.0185 0.0621 0.0621
Plasmodium vivax amine transporter, putative 0.0051 0.0117 0.033
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0088 0.0871
Echinococcus multilocularis somatostatin receptor 0.0185 0.0621 0.0621
Onchocerca volvulus 0.0051 0.0117 0.0551
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0621 0.0621
Brugia malayi hypothetical protein 0.0051 0.0117 0.0117
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0954 0.3512 0.3512
Loa Loa (eye worm) glutaminase 2 0.0276 0.0963 0.0963
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0112 0.0345 0.0345
Giardia lamblia Hypothetical protein 0.0024 0.0013 0.0308
Toxoplasma gondii ABC1 family protein 0.0043 0.0088 0.0238
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0149 0.0412
Brugia malayi hypothetical protein 0.0171 0.0566 0.0566
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0051 0.0117 0.0117
Loa Loa (eye worm) GABA receptor subunit 0.0199 0.0673 0.0673
Echinococcus granulosus intermediate filament protein 0.0033 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0228 0.0784 0.0784
Echinococcus granulosus hyperpolarization activated cyclic 0.0112 0.0345 0.0345
Trypanosoma brucei aminopeptidase, putative 0.0037 0.0065 0.0173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0065 0.0065
Loa Loa (eye worm) glutaminase 0.0276 0.0963 0.0963
Brugia malayi Tachykinin-like peptides receptor 99D 0.0185 0.0621 0.0621
Brugia malayi Cytochrome P450 family protein 0.0054 0.0129 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0095 0.0095
Chlamydia trachomatis 1,4-alpha-glucan branching enzyme 0.0048 0.0105 0.8817
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Schistosoma mansoni inositol monophosphatase 0.0037 0.0064 0.0064
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.0032 0.0032
Echinococcus multilocularis orexin receptor type 2 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Schistosoma mansoni opsin-like receptor 0.0185 0.0621 0.0621
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0077 0.0077
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0119 0.0119
Trypanosoma brucei beta tubulin 0.0022 0.0008 0.0009
Plasmodium vivax glutathione reductase, putative 0.0037 0.0062 0.0168
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Trypanosoma cruzi chloride channel protein, putative 0.0024 0.0013 0.0024
Mycobacterium ulcerans hypothetical protein 0.0043 0.0088 0.0238
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0031 0.0077
Brugia malayi CLC chloride channel protein 0.0024 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Echinococcus multilocularis g-protein coupled receptor 0.0185 0.0621 0.0621
Mycobacterium leprae Probable lipase LipE 0.0043 0.0088 0.0238
Giardia lamblia hypothetical protein 0.0022 0.0007 0.0092
Echinococcus multilocularis beta tubulin 0.0022 0.0008 0.0008
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0035 0.0086
Onchocerca volvulus 0.0185 0.0621 0.2914
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0065 0.0173
Schistosoma mansoni tubulin subunit beta 0.0022 0.0008 0.0008
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Echinococcus multilocularis sodium leak channel non selective protein 0.0112 0.0345 0.0345
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0117 0.0363 0.1022
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0435 0.1559 0.4431
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0031 0.1705
Brugia malayi excitatory GABA receptor EXP-1A 0.037 0.1314 0.1314
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0024 0.0013 0.0024
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0106 0.0325 0.0913
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Echinococcus granulosus alpha 1A adrenergic receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0005 0.0005
Trichomonas vaginalis amylase, putative 0.0108 0.0331 0.3407
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0111 0.0343 0.0343
Treponema pallidum hemolysin (tlyC) 0.0024 0.0013 0.0079
Trichomonas vaginalis glutaminase, putative 0.0276 0.0963 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0088 0.0238
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0112 0.0345 0.0345
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0024 0.0013 0.0024
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0031 0.0248
Schistosoma mansoni hypothetical protein 0.0185 0.0621 0.0621
Schistosoma mansoni tubulin subunit beta 0.0022 0.0008 0.0008
Loa Loa (eye worm) voltage-gated potassium channel 0.0228 0.0784 0.0784
Brugia malayi hypothetical protein 0.0037 0.0065 0.0065
Loa Loa (eye worm) GMP reductase 0.0411 0.147 0.147
Loa Loa (eye worm) integrin beta-2 0.0585 0.2122 0.2122
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0025 0.0025
Echinococcus multilocularis lamin dm0 0.0033 0.0047 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0238 0.0666
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0105
Brugia malayi K+ channel tetramerisation domain containing protein 0.0117 0.0363 0.0363
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0277 0.0776
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0112 0.0345 0.0345
Schistosoma mansoni protein kinase subunit gamma 0.0024 0.0013 0.0013
Onchocerca volvulus 0.0185 0.0621 0.2914
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Schistosoma mansoni chloride channel protein 0.0024 0.0013 0.0013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0345 0.3557
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0117 0.0363 0.1022
Mycobacterium ulcerans aminopeptidase N PepN 0.0037 0.0065 0.0173
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0064 0.0064
Plasmodium falciparum glutathione reductase 0.0037 0.0062 0.0168
Onchocerca volvulus 0.0509 0.1839 0.8629
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0117 0.0363 0.0363
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0185 0.0621 0.0621
Schistosoma mansoni amine GPCR 0.0185 0.0621 0.0621
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0049 0.0049
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0199 0.0673 0.0673
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0088 0.0871
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0112 0.0345 0.0971
Onchocerca volvulus Putative GMP reductase 0.0411 0.147 0.69
Trichomonas vaginalis cyclin A, putative 0.0042 0.0083 0.0823
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0182 0.0611 0.0611
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0112 0.0345 0.0345
Echinococcus multilocularis lamin 0.0033 0.0047 0.0047
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Schistosoma mansoni integrin beta subunit 0.0401 0.1432 0.1432
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0587 0.2131 0.2131
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0064 0.0064
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.037 0.1314 0.1314
Schistosoma mansoni hypothetical protein 0.0513 0.1852 0.1852
Loa Loa (eye worm) hypothetical protein 0.0302 0.106 0.106
Echinococcus multilocularis voltage gated potassium channel 0.0228 0.0784 0.0784
Mycobacterium tuberculosis Conserved protein 0.0024 0.0013 0.0024
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0931 0.3423 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Brugia malayi Dopamine receptor 0.0185 0.0621 0.0621
Echinococcus granulosus receptor type guanylyl cyclase 0.0184 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus glutamate receptor 2 0.0033 0.0049 0.0049
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.137 0.5076 0.5076
Mycobacterium ulcerans cystathionine beta-synthase 0.0024 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Onchocerca volvulus 0.0185 0.0621 0.2914
Echinococcus multilocularis geminin 0.0513 0.1852 0.1852
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0035 0.0035
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0228 0.0784 0.0784
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0022 0.0048
Mycobacterium tuberculosis Conserved protein 0.0024 0.0013 0.0024
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0286 0.0286
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0024 0.0013 0.0024
Loa Loa (eye worm) aminopeptidase N 0.0106 0.0325 0.0325
Schistosoma mansoni cpg binding protein 0.0091 0.0266 0.0266
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Echinococcus multilocularis nAChR subunit 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Toxoplasma gondii CBS domain-containing protein 0.0024 0.0013 0.0024
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.052 0.1878 0.5341
Echinococcus multilocularis peregrin 0.0029 0.0035 0.0035
Schistosoma mansoni acetylcholine receptor-related 0.0171 0.0566 0.0566
Loa Loa (eye worm) ACC-1 protein 0.037 0.1314 0.1314
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0049 0.0049
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0048 0.0105 0.1462
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) beta-lactamase 0.0043 0.0088 0.0088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0345 0.0345
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0149 0.0149
Onchocerca volvulus 0.0302 0.106 0.4975
Loa Loa (eye worm) hypothetical protein 0.0117 0.0363 0.0363
Trypanosoma brucei mitotic cyclin 6 0.0042 0.0083 0.0225
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Schistosoma mansoni sodium/chloride dependent transporter 0.0051 0.0117 0.0117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.022 0.0751 0.0751
Echinococcus granulosus fibrillin 2 0.0022 0.0007 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Loa Loa (eye worm) RGC/RGC protein kinase 0.0184 0.0618 0.0618
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0954 0.3512 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Loa Loa (eye worm) tubulin beta-4 chain 0.0022 0.0008 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0238 0.0666
Mycobacterium ulcerans glycogen branching protein 0.0048 0.0105 0.0286
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0185 0.0621 0.0621
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Onchocerca volvulus 0.0051 0.0117 0.0551
Loa Loa (eye worm) guanylyl cyclase/natriuretic peptide receptor 0.0021 0.0005 0.0005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0171 0.0566 0.0566
Toxoplasma gondii histone lysine methyltransferase SET1 0.0163 0.0537 0.1519
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis adenylate cyclase 0.0021 0.0005 0.0005
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0411 0.147 0.147
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Echinococcus granulosus lamin 0.0033 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0112 0.0345 0.0971
Brugia malayi CBS domain containing protein 0.0024 0.0013 0.0013
Echinococcus granulosus serotonin transporter 0.0302 0.106 0.106
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Brugia malayi chloride channel protein 7 0.0024 0.0013 0.0013
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0112 0.0345 0.0345
Schistosoma mansoni growth hormone secretagogue receptor 0.0185 0.0621 0.0621
Trypanosoma cruzi extracellular receptor, putative 0.0033 0.0049 0.0126
Echinococcus multilocularis potassium voltage gated channel protein 0.0228 0.0784 0.0784
Loa Loa (eye worm) RGC/RGC protein kinase 0.0062 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.0802 0.0802
Trypanosoma cruzi cyclin 6, putative 0.0042 0.0083 0.0225
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0024 0.0013 0.0024
Echinococcus multilocularis neuropeptide receptor 0.0185 0.0621 0.0621
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Onchocerca volvulus 0.0117 0.0363 0.1703
Echinococcus multilocularis serotonin receptor 0.0185 0.0621 0.0621
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0088 0.0871
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0064 0.0147
Giardia lamblia Beta tubulin 0.0022 0.0008 0.0116
Onchocerca volvulus 0.0051 0.0117 0.0551
Brugia malayi EGF-like domain containing protein 0.0022 0.0007 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0013 0.0024
Echinococcus multilocularis nmda type glutamate receptor 0.0033 0.0049 0.0049
Leishmania major cytochrome p450-like protein 0.0026 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Echinococcus granulosus nAChR subunit 0.0199 0.0673 0.0673
Brugia malayi Dopamine receptor protein 2 0.0185 0.0621 0.0621
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0065 0.0173
Echinococcus granulosus g-protein coupled receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0144 0.0466 0.1315
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0149 0.0149
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Trypanosoma brucei potassium voltage-gated channel, putative 0.0117 0.0363 0.1022
Echinococcus granulosus H:Cl exchange transporter 4 0.0024 0.0013 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0621 0.0621
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0037 0.0065 0.0065
Schistosoma mansoni voltage-dependent calcium channel 0.0112 0.0345 0.0345
Schistosoma mansoni 60S ribosomal protein L21 0.0112 0.0345 0.0345
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0345 0.0345
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0088 0.0238
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0088 0.0238
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0065 0.0173
Trypanosoma cruzi chloride channel protein, putative 0.0024 0.0013 0.0024
Echinococcus multilocularis beta tubulin 0.0022 0.0008 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0022 0.0048
Schistosoma mansoni biogenic amine receptor 0.0185 0.0621 0.0621
Brugia malayi G-protein coupled receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) peptidase family M1 containing protein 0.0119 0.0372 0.0372
Onchocerca volvulus 0.037 0.1314 0.6167
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0149 0.0149
Loa Loa (eye worm) tubulin beta-1 chain 0.0022 0.0008 0.0008
Brugia malayi hypothetical protein 0.0033 0.0049 0.0049
Echinococcus multilocularis musashi 0.0033 0.0047 0.0047
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0112 0.0345 0.0345
Loa Loa (eye worm) glutamate receptor 0.0033 0.0049 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0228 0.0784 0.0784
Trichomonas vaginalis cyclin B, putative 0.0042 0.0083 0.0823
Brugia malayi K+ channel tetramerisation domain containing protein 0.0117 0.0363 0.0363
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0065
Schistosoma mansoni alpha-1 adrenergic receptor 0.0185 0.0621 0.0621
Brugia malayi Cation transporter family protein 0.037 0.1314 0.1314
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0954 0.3512 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0587 0.2131 0.2131
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0008 0.0008
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0024 0.0013 0.0013
Brugia malayi TATA binding protein associated factor 0.0037 0.0065 0.0065
Echinococcus multilocularis cyclin B 0.0042 0.0083 0.0083
Echinococcus multilocularis expressed conserved protein 0.0043 0.0085 0.0085
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0156 0.051 0.051
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0088 0.0244
Brugia malayi olfactory channel protein osm-9 0.0112 0.0345 0.0345
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0112 0.0345 0.0345
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Mycobacterium ulcerans beta-lactamase 0.0043 0.0088 0.0238
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0008 0.0008
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0024 0.0013 0.0024
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Trypanosoma brucei beta tubulin 0.0022 0.0008 0.0009
Loa Loa (eye worm) acetylcholine receptor protein 0.0171 0.0566 0.0566
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0117 0.0363 0.0363
Brugia malayi loechrig isoform VII 0.0024 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Echinococcus granulosus sex peptide receptor 0.0185 0.0621 0.0621
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0065 0.0173
Echinococcus granulosus 7tm_1 domain containing protein 0.0185 0.0621 0.0621
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0345 0.3557
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0112 0.0345 0.0345
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0035
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0277 0.0776
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0047 0.0047
Brugia malayi putative neuropeptide receptor 0.0185 0.0621 0.0621
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0185 0.0621 0.2914
Schistosoma mansoni chloride channel protein 0.0024 0.0013 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0035 0.0089
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0112 0.0347 0.0347
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0006 0.0003
Echinococcus granulosus GPCR family 2 0.022 0.0751 0.0751
Echinococcus multilocularis fmrfamide receptor 0.0185 0.0621 0.0621
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Schistosoma mansoni myosin xvIII 0.0185 0.0621 0.0621
Echinococcus multilocularis adenylate cyclase 9 0.0021 0.0005 0.0005
Echinococcus granulosus transient receptor potential cation channel 0.0112 0.0345 0.0345
Mycobacterium ulcerans glutaminase 0.0276 0.0963 0.2731
Brugia malayi hypothetical protein 0.0171 0.0566 0.0566
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0103 0.0314 0.0314
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0058 0.0058
Loa Loa (eye worm) serotonin transporter b 0.0302 0.106 0.106
Trichomonas vaginalis cyclins, putative 0.0042 0.0083 0.0823
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0077 0.0077
Schistosoma mansoni biogenic amine receptor 0.0185 0.0621 0.0621
Echinococcus granulosus adam 0.0022 0.0007 0.0007
Plasmodium falciparum kelch protein K13 0.0117 0.0363 0.1048
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Brugia malayi adenylate cyclase, type IX 0.0021 0.0005 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0095 0.0095
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0031 0.0051
Echinococcus granulosus atrial natriuretic peptide receptor 0.0156 0.051 0.051
Schistosoma mansoni calcium-activated potassium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0509 0.1839 0.1839
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0112 0.0345 0.0345
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0185 0.0621 0.0621
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0024 0.0013 0.0308
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Echinococcus granulosus somatostatin receptor 0.0185 0.0621 0.0621
Schistosoma mansoni neurotransmitter gated ion channel 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0185 0.0621 0.0621
Trypanosoma cruzi GMP reductase 0.0954 0.3512 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0149 0.0412
Mycobacterium ulcerans transcriptional regulator 0.0024 0.0013 0.0024
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0033 0.0049 0.0049
Echinococcus granulosus sodium channel protein 0.0227 0.0779 0.0779
Echinococcus multilocularis tubulin beta 1 chain 0.0022 0.0008 0.0008
Echinococcus granulosus neuropeptide receptor 0.1136 0.4195 0.4195
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0273 0.0765
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Giardia lamblia G2/mitotic-specific cyclin B 0.0042 0.0083 0.2895
Echinococcus granulosus BTB:POZ domain containing protein 0.0117 0.0363 0.0363
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0331 0.3407
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0112 0.0345 0.0345
Echinococcus granulosus cyclin B 0.0042 0.0083 0.0083
Echinococcus multilocularis BTB:POZ domain containing protein 0.0117 0.0363 0.0363
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0083 0.0083
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.0621 0.0621
Schistosoma mansoni amine GPCR 0.0185 0.0621 0.0621
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.0621 0.0621
Trichomonas vaginalis tubulin, putative 0.0022 0.0008 0.0033
Onchocerca volvulus 0.0171 0.0566 0.2654
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0185 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus expressed conserved protein 0.0043 0.0085 0.0085
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus two pore calcium channel protein 1 0.0112 0.0345 0.0345
Brugia malayi ancient conserved domain protein 4 0.0024 0.0013 0.0013
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Schistosoma mansoni voltage-gated potassium channel 0.0117 0.0363 0.0363
Echinococcus granulosus peregrin 0.0029 0.0035 0.0035
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0112 0.0345 0.0345
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0954 0.3512 0.3512
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0064 0.0624
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus ryanodine receptor 44f 0.0112 0.0345 0.0345
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0228 0.0784 0.0784
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0112 0.0345 0.0345
Mycobacterium tuberculosis Conserved protein 0.0043 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.004 0.0076 0.0076
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0031 0.0075
Echinococcus granulosus voltage gated hydrogen channel 1 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Brugia malayi AKH receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Brugia malayi G protein-coupled receptor F59B2.13 0.0185 0.0621 0.0621
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0587 0.2131 0.2131
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0048 0.0105 0.0105
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0185 0.0621 0.0621
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0051 0.0117 0.0117
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0062 0.0164
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0106 0.0325 0.3342
Onchocerca volvulus 0.0117 0.0363 0.1703
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0088 0.0871
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0171 0.0566 0.0566
Echinococcus multilocularis short transient receptor potential channel 6 0.0112 0.0345 0.0345
Trypanosoma cruzi chloride channel protein, putative 0.0024 0.0013 0.0024
Schistosoma mansoni voltage-gated potassium channel 0.0228 0.0784 0.0784
Echinococcus granulosus dnaJ subfamily B 0.0805 0.2949 0.2949
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0112 0.0345 0.0345
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.037 0.1314 0.1314
Echinococcus granulosus hyperpolarization activated cyclic 0.0112 0.0345 0.0345
Trypanosoma brucei potassium voltage-gated channel, putative 0.0117 0.0363 0.1022
Echinococcus multilocularis neuropeptide s receptor 0.0185 0.0621 0.0621
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.037 0.1314 0.1314
Echinococcus multilocularis two pore calcium channel protein 1 0.0112 0.0345 0.0345
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0227 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0051 0.0117 0.0117
Brugia malayi beta-lactamase family protein 0.0043 0.0088 0.0088
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0033 0.0049 0.0049
Onchocerca volvulus 0.0185 0.0621 0.2914
Brugia malayi Tubulin beta-1 chain 0.0022 0.0008 0.0008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0185 0.0621 0.0621
Mycobacterium ulcerans lipase LipD 0.0043 0.0088 0.0238
Toxoplasma gondii transporter, cation channel family protein 0.0112 0.0345 0.0971
Echinococcus multilocularis sodium and chloride dependent glycine 0.0051 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Onchocerca volvulus 0.0185 0.0621 0.2914
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.0621 0.0621
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0273 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Echinococcus granulosus retinal guanylyl cyclase 2 0.0029 0.0032 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.022 0.0751 0.0751
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0112 0.0345 0.0345
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0024
Echinococcus granulosus retinal guanylyl cyclase 2 0.0029 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0151 0.0491 0.0491
Onchocerca volvulus 0.0033 0.0049 0.0229
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0024 0.0013 0.0024
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0185 0.0621 0.0621
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0112 0.0345 0.0345
Onchocerca volvulus 0.0021 0.0005 0.0021
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0185 0.0621 0.0621
Brugia malayi Kelch motif family protein 0.0103 0.0314 0.0314
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0062 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Schistosoma mansoni amine GPCR 0.0185 0.0621 0.0621
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0088 0.0238
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0106 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0048 0.0105 0.0105
Onchocerca volvulus 0.0185 0.0621 0.2914
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Schistosoma mansoni voltage-gated potassium channel 0.268 1 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0199 0.0673 0.0673
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.0345 0.0971
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Loa Loa (eye worm) solute carrier family 6 member 4 0.0302 0.106 0.106
Entamoeba histolytica hypothetical protein 0.011 0.0337 0.4944
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0238 0.0666
Echinococcus multilocularis sex peptide receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0088 0.0088
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0024 0.0013 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis ryanodine receptor 44f 0.0112 0.0345 0.0345
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0065 0.0173
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0024 0.0013 0.0024
Echinococcus multilocularis muscleblind protein 0.015 0.049 0.049
Leishmania major inosine-5-monophosphate dehydrogenase 0.0954 0.3512 1
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Giardia lamblia Tenascin-37 0.0022 0.0007 0.0092
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0051 0.0117 0.0117
Echinococcus multilocularis two pore calcium channel protein 2 0.0112 0.0345 0.0345
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0345 0.0345
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0024 0.0013 0.0013
Loa Loa (eye worm) ACC-1 protein 0.037 0.1314 0.1314
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0322
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0185 0.0621 0.0621
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0065 0.0173
Echinococcus multilocularis transfer RNA-Gly 0.0228 0.0784 0.0784
Loa Loa (eye worm) TYRA-2 protein 0.0185 0.0621 0.0621
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0184 0.0184
Onchocerca volvulus 0.0042 0.0083 0.0391
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.037 0.1314 0.1314
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0331 0.3407
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0337 0.0337
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0954 0.3512 1
Brugia malayi hypothetical protein 0.0185 0.0621 0.0621
Onchocerca volvulus 0.009 0.0263 0.1235
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0005 0.0005
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0278 0.097 0.4551
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0064 0.0624
Loa Loa (eye worm) hypothetical protein 0.0168 0.0554 0.0554
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0069 0.0184 0.0184
Brugia malayi beta-lactamase 0.0043 0.0088 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0088 0.0238
Loa Loa (eye worm) voltage-dependent calcium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis adam 0.0022 0.0007 0.0007
Trypanosoma cruzi cyclin, putative 0.0042 0.0083 0.0225
Brugia malayi neuropeptide F receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0065
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0112 0.0345 0.0345
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0112 0.0345 0.0345
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0008 0.0008
Schistosoma mansoni inositol monophosphatase 0.0037 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0199 0.0673 0.0673
Schistosoma mansoni voltage-gated potassium channel 0.0117 0.0363 0.0363
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0037 0.0065 0.0065
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0112 0.0345 0.0345
Schistosoma mansoni glutaminase 0.0276 0.0963 0.0963
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0228 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0302 0.106 0.106
Trypanosoma brucei btb/poz domain containing protein, putative 0.0117 0.0363 0.1022
Echinococcus granulosus transient receptor potential cation channel 0.0112 0.0345 0.0345
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0277 0.1299
Schistosoma mansoni nAChR subunit 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0273 0.0765
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0621 0.0621
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0185 0.0621 0.0621
Giardia lamblia Neurogenic locus notch-like protein 0.0022 0.0007 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0065
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.037 0.1314 0.1314
Echinococcus multilocularis potassium large conductance calcium activated 0.0112 0.0345 0.0345
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.2563 0.9562 0.9562
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.022 0.0751 0.0751
Plasmodium vivax kelch protein K13, putative 0.0117 0.0363 0.1048
Onchocerca volvulus 0.0117 0.0363 0.1703
Echinococcus granulosus adenylate cyclase 9 0.0111 0.0343 0.0343
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.037 0.1314 0.1314
Brugia malayi putative neuropeptide receptor NPR1 0.0185 0.0621 0.0621
Echinococcus granulosus neuropeptide receptor 0.0185 0.0621 0.0621
Brugia malayi Cation transporter family protein 0.0509 0.1839 0.1839
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Brugia malayi Receptor family ligand binding region containing protein 0.0033 0.0049 0.0049
Echinococcus multilocularis potassium voltage gated channel protein 0.268 1 1
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0117 0.0363 0.1048
Onchocerca volvulus 0.0117 0.0363 0.1703
Schistosoma mansoni hypothetical protein 0.0185 0.0621 0.0621
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Echinococcus multilocularis glycine receptor subunit alpha 1 0.037 0.1314 0.1314
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0025 0.0025
Echinococcus granulosus two pore calcium channel protein 2 0.0112 0.0345 0.0345
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0112 0.0345 0.0345
Entamoeba histolytica hypothetical protein 0.0199 0.0673 1
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0149 0.0412
Brugia malayi metabotropic glutamate receptor type 2 0.0033 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0587 0.2131 0.2131
Echinococcus granulosus allatostatin A receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis allatostatin A receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0199 0.0673 0.3159
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0621 0.0621
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0199 0.0673 0.0673
Giardia lamblia High cysteine protein 0.0022 0.0007 0.0092
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0024 0.0013 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0112 0.0345 0.0345
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0048 0.0105 0.1462
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0117 0.0363 0.0363
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0051 0.0117 0.0117
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.01 0.0302 0.0302
Schistosoma mansoni transient receptor potential channel 4 0.0112 0.0345 0.0345
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0106 0.0325 0.3342
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0228 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Schistosoma mansoni glutamate receptor NMDA 0.0033 0.0049 0.0049
Onchocerca volvulus 0.0112 0.0345 0.162
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0051 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0083
Loa Loa (eye worm) IMP dehydrogenase 1 0.0954 0.3512 0.3512
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.0621 0.0621
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0088 0.0238
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0069 0.0184 0.0512
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0112 0.0345 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0103 0.0314 0.0314
Echinococcus granulosus voltage gated potassium channel 0.0228 0.0784 0.0784
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0277 0.0277
Brugia malayi Serotonin receptor 0.0185 0.0621 0.0621
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.052 0.1878 0.5341
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Giardia lamblia Beta tubulin 0.0022 0.0008 0.0116
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0051 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0047 0.0047
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0065 0.0065
Schistosoma mansoni transient receptor potential channel 0.0112 0.0345 0.0345
Schistosoma mansoni tubulin subunit beta 0.0022 0.0008 0.0008
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0029 0.0032 0.0032
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0065 0.0178
Schistosoma mansoni histamine h1 receptor 0.0185 0.0621 0.0621
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0099 0.0985
Echinococcus multilocularis protein jagged 2 0.0022 0.0007 0.0007
Onchocerca volvulus 0.0185 0.0621 0.2914
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Echinococcus granulosus metabotropic glutamate receptor 5 0.0033 0.0049 0.0049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0051 0.0117 0.0117
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.022 0.0751 0.0751
Trichomonas vaginalis cyclins, putative 0.0042 0.0083 0.0823
Echinococcus granulosus glycine receptor subunit alpha 1 0.037 0.1314 0.1314
Schistosoma mansoni voltage-gated potassium channel 0.0228 0.0784 0.0784
Plasmodium falciparum protein MAM3, putative 0.0024 0.0013 0.0024
Brugia malayi RE15519p 0.0185 0.0621 0.0621
Trichomonas vaginalis tubulin gamma chain, putative 0.0022 0.0008 0.0033
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0112 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0805 0.2949 0.2949
Schistosoma mansoni adenylate cyclase 0.0021 0.0005 0.0005
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0257 0.089 0.089
Leishmania major guanosine monophosphate reductase 0.0954 0.3512 1
Echinococcus multilocularis fmrfamide receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0022 0.0022
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0035 0.0086
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Entamoeba histolytica hypothetical protein 0.011 0.0337 0.4944
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0112 0.0345 0.0345
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0064 0.017
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Onchocerca volvulus 0.0168 0.0554 0.2602
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.268 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0078 0.0078
Echinococcus granulosus nmda type glutamate receptor 0.0033 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0112 0.0345 0.0345
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0228 0.0784 0.0784
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0077 0.0077
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0106 0.0325 0.0325
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0065 0.0173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0064 0.0064
Plasmodium falciparum tubulin beta chain 0.0022 0.0008 0.0009
Onchocerca volvulus 0.0043 0.0088 0.0413
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Brugia malayi Thioredoxin reductase 0.0037 0.0062 0.0062
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.005 0.0129
Loa Loa (eye worm) hypothetical protein 0.0302 0.106 0.106
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Schistosoma mansoni amine GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0117 0.0363 0.0363
Schistosoma mansoni cpg binding protein 0.0091 0.0266 0.0266
Loa Loa (eye worm) ion channel NompC 0.0112 0.0345 0.0345
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.037 0.1314 0.1314
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0277 0.4043
Toxoplasma gondii transporter, cation channel family protein 0.0112 0.0345 0.0971
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.037 0.1314 0.1314
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0024 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.011 0.0337 0.4944
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.0621 0.0621
Schistosoma mansoni neuropeptide f receptor 76f 0.0185 0.0621 0.0621
Leishmania major hypothetical protein, unknown function 0.0112 0.0345 0.0971
Echinococcus granulosus geminin 0.0513 0.1852 0.1852
Brugia malayi MH2 domain containing protein 0.0233 0.0802 0.0802
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0621 0.0621
Entamoeba histolytica hypothetical protein 0.0033 0.0049 0.0618
Echinococcus granulosus glycine receptor subunit alpha 1 0.037 0.1314 0.1314
Echinococcus granulosus hypothetical protein 0.0112 0.0345 0.0345
Echinococcus multilocularis transient receptor potential cation channel 0.0112 0.0345 0.0345
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0149 0.0412
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0051 0.0117 0.0117
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0065 0.0065
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.0621 0.0621
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus transient receptor potential gamma protein 0.0112 0.0345 0.0345
Brugia malayi hypothetical protein 0.0112 0.0345 0.0345
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0112 0.0345 0.0345
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0228 0.0784 0.0784
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0185 0.0621 0.0621
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0051 0.0117 0.0117
Echinococcus multilocularis adenylate cyclase 9 0.0021 0.0005 0.0005
Brugia malayi neuropeptide F receptor 0.0185 0.0621 0.0621
Trypanosoma brucei trypanothione reductase 0.0037 0.0062 0.0164
Schistosoma mansoni tubulin subunit beta 0.0022 0.0008 0.0008
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0065 0.0634
Trypanosoma cruzi cyclin, putative 0.0042 0.0083 0.0225
Leishmania major hypothetical protein, conserved 0.0043 0.0088 0.0238
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0238 0.0666
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.037 0.1314 0.1314
Echinococcus granulosus tachykinin peptides receptor 99D 0.0185 0.0621 0.0621
Onchocerca volvulus 0.0188 0.0632 0.2965
Echinococcus granulosus neuropeptide s receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.037 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0029 0.0032 0.0032
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0022 0.0022
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0048 0.0105 0.0286
Echinococcus granulosus tyrosine kinase 0.004 0.0076 0.0076
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0065 0.0065
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0954 0.3512 1
Echinococcus multilocularis muscleblind protein 1 0.015 0.049 0.049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0095 0.0095
Schistosoma mansoni protein tyrosine kinase 0.0029 0.0032 0.0032
Toxoplasma gondii glycosyltransferase 0.0048 0.0105 0.0286
Echinococcus granulosus adenylate cyclase type IX 0.0021 0.0005 0.0005
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0587 0.2131 0.2131
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0049 0.0049
Loa Loa (eye worm) loechrig isoform VII 0.0024 0.0013 0.0013
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0033 0.0049 0.0049
Echinococcus granulosus potassium voltage gated channel subfamily A 0.268 1 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0112 0.0345 0.0971
Echinococcus granulosus tubulin beta 1 chain 0.0022 0.0008 0.0008
Echinococcus granulosus g protein coupled receptor 0.0185 0.0621 0.0621
Echinococcus granulosus TRP transient receptor potential channel 0.0112 0.0345 0.0345
Schistosoma mansoni intermediate filament proteins 0.0033 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0117 0.0363 0.0363
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0088 0.0088
Echinococcus granulosus g protein coupled receptor 0.0185 0.0621 0.0621
Trypanosoma cruzi aminopeptidase, putative 0.0106 0.0325 0.0913
Onchocerca volvulus Alhambra homolog 0.0029 0.0035 0.0164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0088 0.0088
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0064 0.0064
Brugia malayi hypothetical protein 0.0171 0.0566 0.0566
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.0621 0.0621
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0021 0.0005 0.0005
Echinococcus granulosus glutamate receptor 2 0.0033 0.0049 0.0049
Echinococcus granulosus voltage gated potassium channel 0.0112 0.0345 0.0345
Schistosoma mansoni lamin 0.0033 0.0047 0.0047
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0008 0.0033
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0024 0.0013 0.0308
Echinococcus multilocularis tubulin subunit beta 0.0022 0.0008 0.0008
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0117 0.0363 0.0363
Trypanosoma brucei polo-like protein kinase 0.0094 0.0277 0.0776
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0031 0.0075
Brugia malayi beta-lactamase family protein 0.0043 0.0088 0.0088
Echinococcus granulosus beta tubulin 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0337 0.0337
Schistosoma mansoni opsin-like receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0185 0.0621 0.0621
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.0345 0.0971
Echinococcus multilocularis voltage dependent calcium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0095 0.0095
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.0621 0.0621
Brugia malayi cation channel family protein 0.0112 0.0345 0.0345
Echinococcus multilocularis dnaJ subfamily B 0.0805 0.2949 0.2949
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus sodium and chloride dependent glycine 0.0051 0.0117 0.0117
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0345 0.0345
Brugia malayi Metabotropic glutamate receptor precursor. 0.0033 0.0049 0.0049
Loa Loa (eye worm) beta-tubulin 0.0022 0.0008 0.0008
Echinococcus multilocularis adenylate cyclase type IX 0.0021 0.0005 0.0005
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0049 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0152 0.0152
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0475 0.1711 0.1711
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0024 0.0013 0.0024
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0049 0.0049
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0062 0.0062
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0008 0.0008
Echinococcus granulosus 7TM GPCR rhodopsin 0.0185 0.0621 0.0621
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0199 0.0673 0.0673
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0411 0.147 0.147
Brugia malayi Cytochrome P450 family protein 0.0026 0.0022 0.0022
Brugia malayi G protein-coupled receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0157 0.0516 0.0516
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.037 0.1314 0.1314
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.0621 0.0621
Plasmodium vivax tubulin beta chain, putative 0.0022 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Leishmania major cyclin 0.0042 0.0083 0.0225
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0064 0.017
Echinococcus granulosus glycine receptor subunit beta 0.037 0.1314 0.1314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0695 0.2538 0.2538
Mycobacterium tuberculosis Conserved protein 0.0043 0.0088 0.0238
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0302 0.0302
Onchocerca volvulus 0.0185 0.0621 0.2914
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.015 0.049 0.049
Onchocerca volvulus Putative nachr subunit 0.0587 0.2131 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0112 0.0345 0.0345
Onchocerca volvulus 0.0185 0.0621 0.2914
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0112 0.0345 0.0345
Trichomonas vaginalis alpha-amylase, putative 0.0096 0.0286 0.2943
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0509 0.1839 0.1839
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0621 0.0621
Leishmania major chloride channel protein, putative 0.0024 0.0013 0.0024
Echinococcus multilocularis short transient receptor potential channel 6 0.0112 0.0345 0.0345
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.0621 0.0621
Giardia lamblia PHD finger protein 15 0.0029 0.0035 0.1113
Schistosoma mansoni two-pore calcium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) norepinephrine transporter 0.0302 0.106 0.106
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0117 0.033
Brugia malayi EGF-like domain containing protein 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0047 0.0047
Trichomonas vaginalis amylase, putative 0.0048 0.0105 0.1049
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.0621 0.0621
Leishmania major potassium voltage-gated channel, putative 0.0117 0.0363 0.1022
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0065 0.0173
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Echinococcus granulosus potassium voltage gated channel protein 0.0112 0.0345 0.0345
Brugia malayi Angiotensin-converting enzyme family protein 0.0157 0.0516 0.0516
Brugia malayi larval opioid receptor 0.0185 0.0621 0.0621
Trichomonas vaginalis starch branching enzyme II, putative 0.0048 0.0105 0.1049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Brugia malayi sulfakinin receptor protein 0.0185 0.0621 0.0621
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0064 0.017
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0029 0.0032 0.0032
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0302 0.106 0.106
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0112 0.0345 0.0345
Echinococcus granulosus H:Cl exchange transporter 3 0.0024 0.0013 0.0013
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0112 0.0345 0.0345
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.0621 0.0621
Echinococcus multilocularis conserved hypothetical protein 0.0112 0.0345 0.0345
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0065 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0277 0.2842
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0064 0.085
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0065 0.0178
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0117 0.0363 0.1022
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0117 0.0363 0.0363
Loa Loa (eye worm) glutathione reductase 0.0037 0.0062 0.0062
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0117 0.0363 0.0363
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0022 0.0007 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0621 0.0621
Toxoplasma gondii hypothetical protein 0.0022 0.0007 0.0007
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0049 0.0049
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0024 0.0013 0.0024
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0008 0.0008
Echinococcus granulosus cpg binding protein 0.0091 0.0266 0.0266
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0088 0.0238
Toxoplasma gondii beta-tubulin, putative 0.0022 0.0008 0.0009
Trichomonas vaginalis cyclin B, putative 0.0042 0.0083 0.0823
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0171 0.0566 0.0566
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0171 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Giardia lamblia Beta tubulin 0.0022 0.0008 0.0116
Echinococcus granulosus neuropeptide receptor A26 0.0185 0.0621 0.0621
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0277 0.0277
Schistosoma mansoni soluble guanylate cyclase gcy 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Brugia malayi jmjC domain containing protein 0.004 0.0077 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.0228 0.0784 0.0784
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0078 0.0078
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0024 0.0013 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0621 0.0621
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0112 0.0345 0.0345
Echinococcus granulosus short transient receptor potential channel 6 0.0112 0.0345 0.0345
Brugia malayi hypothetical protein 0.0106 0.0325 0.0325
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0049 0.0049
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0337 0.0337
Schistosoma mansoni hypothetical protein 0.0475 0.1711 0.1711
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.022 0.0751 0.0751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0095 0.0095
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0064 0.017
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0021 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.0112 0.0345 0.0971
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0024 0.0013 0.0013
Echinococcus multilocularis neuropeptide receptor 0.1136 0.4195 0.4195
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.037 0.1314 0.1314
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0228 0.0784 0.0784
Trypanosoma cruzi CYC2-like cyclin, putative 0.0042 0.0083 0.0225
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.005 0.0129
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0587 0.2131 0.2131
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0031 0.0075
Echinococcus multilocularis hyperpolarization activated cyclic 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0185 0.0621 0.0621
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0185 0.0621 0.0621
Onchocerca volvulus 0.0185 0.0621 0.2914
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0083
Schistosoma mansoni nAChR subunit 0.037 0.1314 0.1314
Schistosoma mansoni tubulin subunit beta 0.0022 0.0008 0.0008
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0954 0.3512 1
Loa Loa (eye worm) calcium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0022 0.0022
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.037 0.1314 0.1314
Echinococcus granulosus neuropeptide FF receptor 2 0.0185 0.0621 0.0621
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0049 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0088 0.0088
Brugia malayi Receptor family ligand binding region containing protein 0.0184 0.0618 0.0618
Loa Loa (eye worm) voltage-gated potassium channel 0.0112 0.0345 0.0345
Trichomonas vaginalis amylase, putative 0.0108 0.0331 0.3407
Trypanosoma brucei Aminopeptidase M1, putative 0.0106 0.0325 0.0913
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0106 0.0325 0.0913
Onchocerca volvulus 0.0185 0.0621 0.2914
Schistosoma mansoni neuropeptide receptor 0.1136 0.4195 0.4195
Schistosoma mansoni neurotransmitter gated ion channel 0.0199 0.0673 0.0673
Echinococcus granulosus dro:myosuppressin receptor 0.0185 0.0621 0.0621
Brugia malayi hypothetical protein 0.0171 0.0566 0.0566
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0185 0.0621 0.0621
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0024 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0028 0.0031 0.0346
Trichomonas vaginalis cyclins, putative 0.0042 0.0083 0.0823
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.037 0.1314 0.1314
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0106 0.0325 0.0325
Leishmania major chloride channel protein, putative 0.0024 0.0013 0.0024
Schistosoma mansoni hypothetical protein 0.0513 0.1852 0.1852
Leishmania major beta tubulin 0.0022 0.0008 0.0009
Echinococcus granulosus adenylate cyclase 9 0.0021 0.0005 0.0005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.037 0.1314 0.1314
Loa Loa (eye worm) RGC/RGC protein kinase 0.0184 0.0618 0.0618
Echinococcus granulosus potassium large conductance calcium activated 0.0112 0.0345 0.0345
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0171 0.0566 0.0566
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0112 0.0345 0.0345
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0042 0.0083 0.0225
Brugia malayi K+ channel tetramerisation domain containing protein 0.0117 0.0363 0.0363
Brugia malayi Integrin beta pat-3 precursor 0.0585 0.2122 0.2122
Schistosoma mansoni neuropeptide receptor 0.0185 0.0621 0.0621
Brugia malayi Muscleblind-like protein 0.015 0.049 0.049
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0064 0.017
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.0621 0.0621
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0277 0.0277
Loa Loa (eye worm) inositol-1 0.0037 0.0064 0.0064
Echinococcus granulosus fibrillin 1 0.0022 0.0007 0.0007
Brugia malayi voltage-dependent calcium channel 0.0112 0.0345 0.0345
Echinococcus multilocularis potassium voltage gated channel protein 0.0228 0.0784 0.0784
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.037 0.1314 0.1314
Plasmodium falciparum amino acid transporter, putative 0.0051 0.0117 0.033
Brugia malayi latrophilin 2 splice variant baaae 0.0475 0.1711 0.1711
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0029 0.0032 0.0032
Echinococcus granulosus voltage dependent calcium channel 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0171 0.0566 0.0566
Echinococcus granulosus calcium activated potassium channel 0.0112 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.037 0.1314 0.1314
Toxoplasma gondii CBS domain-containing protein 0.0024 0.0013 0.0024
Toxoplasma gondii beta-1 tubulin, putative 0.0022 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0069 0.0184 0.0184
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0954 0.3512 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0112 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.022 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0045

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) > 100 uM Cytotoxic dose required to reduce the viability of normal uninfected MT-4 cells. ChEMBL. 3172142
Displacement (binding) = 28 % Binding affinity determined by displacement of specific binding of [125I]-N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat Adenosine A3 receptor ChEMBL. 7707320
Displacement (binding) = 31 % Binding affinity determined on Adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]-PIA as radioligand. ChEMBL. 7707320
Displacement (binding) = 39 % Binding affinity determined on Adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand. ChEMBL. 7707320
GI (functional) = 48.7 % Growth inhibition of Trichomonas vaginalis T1 at 100 uM after 24 hrs by hemocytometry ChEMBL. 22579483
IC50 (binding) = 15 uM Compound was evaluated for inhibition of adenylate cyclase from rat brain ChEMBL. 14971900
IC50 (ADMET) > 250 uM Cytotoxicity against human HaCaT cells assessed as inhibition of cell viability after 48 hrs by MTT assay ChEMBL. No reference
ID50 (binding) > 1000 uM Compound was tested for inhibit phosphorylation of [3H]-D-T catalyzed by HSV 1 thymidine kinase ChEMBL. 1331461
Inhibition (ADMET) = 106.4078445 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 112.3231235 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Kcat (binding) = 0.37 /s Activity of human wild type deoxycytidine kinase in presence of UTP ChEMBL. 18570408
Kcat (binding) = 1.82 /s Activity of Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase ChEMBL. 17526755
Kcat (binding) = 2.1 /s Activity of human wild type deoxycytidine kinase in presence of ATP ChEMBL. 18570408
Kcat/Km (binding) = 6.22 10'4/M/s Ratio of kcat to Km for Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase ChEMBL. 17526755
Ki (binding) = 23.3 uM Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-DPCPX as radioligand ChEMBL. 7562934
Km (binding) = 8.5 uM Activity of human wild type deoxycytidine kinase in presence of UTP ChEMBL. 18570408
Km (binding) = 29.2 uM Activity of Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase ChEMBL. 17526755
Km (binding) = 31 uM Kinetic constant (Km) for the deamination of compound by adenosine deaminase ChEMBL. 10673097
Km (binding) = 115 uM Activity of human wild type deoxycytidine kinase in presence of ATP ChEMBL. 18570408
MIC (functional) = 20 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Respiratory syncytial virus (RSV) (Long) induced cytopathicity in human carcinoma cells (HeLa) ChEMBL. 8176708
MIC (functional) > 100 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Varicella Zoster virus (VZV) (Oka) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) > 100 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce TK Varicella Zoster virus (VZV) (07/1) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) > 100 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (Davis) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) > 100 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (AD-169) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) = 200 ug ml-1 Minimum inhibitory concentration to reduce cytopathicity by 50% in morphology of human carcinoma cells (HeLa) ChEMBL. 8176708
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration ChEMBL. 3497272
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration. ChEMBL. 3497272
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272
Ratio (binding) = 0.0182 /s/microM Ratio of Kcat for human wild type deoxycytidine kinase to Km for human wild type deoxycytidine kinase in presence of ATP ChEMBL. 18570408
Ratio (binding) = 0.0435 /s/microM Ratio of Kcat for human wild type deoxycytidine kinase to Km for human wild type deoxycytidine kinase in presence of UTP ChEMBL. 18570408
Toxicity (ADMET) = 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration; Range is 10-40 ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272
Vmax (binding) = 4.1 U/mg Activity of Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase ChEMBL. 17526755
Vmax (binding) = 353 uM min-1 (mg of protein)-1 Kinetic constant (Vmax) for the deamination of compound by adenosine deaminase ChEMBL. 10673097

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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