Detailed information for compound 662898

Basic information

Technical information
  • TDR Targets ID: 662898
  • Name: N-(3-bromophenyl)-2-(4-methylphenyl)sulfanylp ropanamide
  • MW: 350.273 | Formula: C16H16BrNOS
  • H donors: 1 H acceptors: 1 LogP: 4.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Sc1ccc(cc1)C)C)Nc1cccc(c1)Br
  • InChi: 1S/C16H16BrNOS/c1-11-6-8-15(9-7-11)20-12(2)16(19)18-14-5-3-4-13(17)10-14/h3-10,12H,1-2H3,(H,18,19)
  • InChiKey: OVCXJCYTIRECKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-bromophenyl)-2-(4-methylphenyl)sulfanyl-propanamide
  • N-(3-bromophenyl)-2-[(4-methylphenyl)thio]propanamide
  • N-(3-bromophenyl)-2-[(4-methylphenyl)thio]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0508 0.1572
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0024 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0909 0.449
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0274 0.0831
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0219 0.0338
Brugia malayi CXXC zinc finger family protein 0.0087 0.0801 0.0801
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0573 0.1779
Loa Loa (eye worm) hypothetical protein 0.0131 0.1291 0.1282
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Brugia malayi jmjC domain containing protein 0.0032 0.0184 0.0184
Onchocerca volvulus 0.0035 0.0219 0.1036
Onchocerca volvulus Serine\/threonine kinase homolog 0.0195 0.2011 1
Echinococcus multilocularis Smad4 0.0017 0.0011 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.263 0.2621
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0478 0.1478
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.014 0.014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0048 0.0042
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0418 0.0413
Trypanosoma brucei protein kinase, putative 0.0053 0.0418 0.1288
Loa Loa (eye worm) cysteine protease 0.0018 0.0017 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3169 1
Brugia malayi MH2 domain containing protein 0.0017 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0185 0.1902 0.436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0037
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0184 0.0178
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0013
Schistosoma mansoni cpg binding protein 0.0094 0.0878 0.2006
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0027 0.0021
Echinococcus granulosus ferritin 0.0017 0.0015 0.001
Plasmodium vivax vivapain-2 0.0018 0.0017 0.0085
Schistosoma mansoni hypothetical protein 0.0403 0.4355 1
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0048
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0219 0.0338
Leishmania major DNA polymerase kappa, putative 0.0018 0.0024 0.0039
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0219 0.0338
Leishmania major DNA damage repair protein, putative 0.0018 0.0024 0.0039
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0395 0.0626
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0122 0.0267
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0045 0.0034
Schistosoma mansoni tsg101-related 0.0119 0.1157 0.2648
Echinococcus granulosus p2X purinoceptor 4 0.0052 0.0407 0.0401
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0048 0.0183
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0219 0.0208
Echinococcus granulosus kelch ECH associated protein 1 0.0194 0.2001 0.1997
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0219 0.0213
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.3169 1
Brugia malayi Probable ClpP-like protease 0.0078 0.0697 0.0697
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0418 0.1288
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0112 0.1084 0.1084
Schistosoma mansoni hypothetical protein 0.0334 0.3578 0.8212
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0192 0.1985 0.1977
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0099 0.0277
Brugia malayi jmjC domain containing protein 0.0032 0.0184 0.0184
Giardia lamblia DNA damage repair protein 0.0018 0.0024 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0048 0.0048
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0017 0.0012 0.0001
Brugia malayi PHD-finger family protein 0.0029 0.0148 0.0148
Loa Loa (eye worm) fli-1 protein 0.0235 0.2461 0.2452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0024 0.0039
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0162 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0219 0.1036
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0112 0.1084 0.3397
Trypanosoma brucei unspecified product 0.004 0.0274 0.0831
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Entamoeba histolytica hypothetical protein 0.011 0.1055 0.5215
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0015 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0063 0.0058
Leishmania major hypothetical protein, conserved 0.0025 0.0099 0.0277
Echinococcus multilocularis muscleblind protein 0.0904 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0528 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0048
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.8922 0.8921
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.084 0.0835
Brugia malayi ecdysteroid receptor 0.002 0.0048 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0382 0.0371
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0024 0.0073
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0184 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0219 0.1036
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0697 0.112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0048
Onchocerca volvulus 0.0035 0.0219 0.1036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0048
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0048 0.0097
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0099 0.0516
Schistosoma mansoni hypothetical protein 0.0194 0.2007 0.4602
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Schistosoma mansoni tsg101-related 0.0097 0.0912 0.2084
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0001
Echinococcus granulosus Smad4 0.0017 0.0011 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0048 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0488 0.5315 0.5309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Schistosoma mansoni survival motor neuron protein 0.01 0.094 0.2149
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0017 0.0012 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0027 0.0049
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0184 0.041
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0483 0.1096
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0122 0.161
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0219 0.0338
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0478 0.0762
Echinococcus granulosus muscleblind protein 0.0904 1 1
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0123 0.0112
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0143 0.1426 0.1421
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0011 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0048 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0088 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0393 0.121
Brugia malayi ethe1-prov protein 0.0017 0.0012 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1055 0.1049
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0013
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0112 0.1084 0.1079
Leishmania major hypothetical protein, conserved 0.0046 0.0333 0.1019
Brugia malayi hypothetical protein 0.0017 0.0012 0.0012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0697 0.4048
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0143 0.1426 0.1421
Echinococcus granulosus smad 0.0017 0.0011 0.0005
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Giardia lamblia DINP protein human, muc B family 0.0058 0.0478 0.2333
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0112 0.1084 0.2479
Brugia malayi polk-prov protein 0.0018 0.0024 0.0024
Brugia malayi Ets-domain containing protein 0.0077 0.0689 0.0689
Schistosoma mansoni P2X receptor subunit 0.0052 0.0407 0.0921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.084 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Brugia malayi Ets-domain containing protein 0.0077 0.0689 0.0689
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0015 0.0006
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0017 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0483 0.0769
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0483 0.0477
Schistosoma mansoni Smad4 0.0017 0.0011 0.0012
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1405 0.4412
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0195 0.2011 0.2007
Echinococcus multilocularis smad 0.0017 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0331
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.058 0.0575
Mycobacterium tuberculosis Conserved protein 0.0035 0.0219 0.0338
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0112 0.1084 0.3397
Loa Loa (eye worm) hypothetical protein 0.0052 0.0404 0.0393
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0478 0.0473
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0112 0.1084 0.5362
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0122 0.161
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.1291 0.1282
Echinococcus granulosus cpg binding protein 0.0094 0.0878 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0208
Brugia malayi hypothetical protein 0.0488 0.5315 0.5315
Onchocerca volvulus 0.0161 0.1635 0.8117
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0219 0.0338
Echinococcus granulosus p2X purinoceptor 4 0.0052 0.0407 0.0401
Loa Loa (eye worm) hypothetical protein 0.0161 0.1635 0.1626
Schistosoma mansoni hypothetical protein 0.0334 0.3578 0.8212
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1405 0.4412
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0418 0.2033
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0689 0.0679
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0195 0.2011 0.2007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0478 0.2333
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0418 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0042 0.0152
Schistosoma mansoni ferritin light chain 0.0017 0.0015 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1055 0.2411
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0261 0.0255
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0219 0.0219
Echinococcus granulosus dna polymerase eta 0.0109 0.1047 0.1041
Trypanosoma brucei beta lactamase 0.0199 0.2056 0.6477
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0112 0.1084 0.5362
Onchocerca volvulus Huntingtin homolog 0.0131 0.1291 0.6399
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0561 0.6136 1
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4355 0.4352
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0017 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.1263 0.2891
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0099 0.1275
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0697 0.4048
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0024 0.0181
Brugia malayi hypothetical protein 0.0143 0.1426 0.1426
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.1706 1
Trypanosoma brucei polo-like protein kinase 0.0195 0.2011 0.6334
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0573 0.1779
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.0012 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Echinococcus granulosus kelch ECH associated protein 1 like 0.0194 0.2001 0.1997
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.084 0.084
Echinococcus multilocularis p2X purinoceptor 4 0.0052 0.0407 0.0401
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0212 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0697 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0048
Echinococcus granulosus ubiquitin specific protease 41 0.0112 0.1084 0.1079
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0017 0.0012 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0048 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0561 0.6136 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0037
Brugia malayi Cytochrome P450 family protein 0.005 0.0382 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0024 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3169 1
Leishmania major cathepsin L-like protease 0.0067 0.0573 0.1779
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0042 0.0152
Echinococcus multilocularis dna polymerase eta 0.0109 0.1047 0.1041
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0017 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0099 0.1275
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.058 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0037
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0478 0.0473
Echinococcus multilocularis zinc phosphodiesterase 0.0017 0.0012 0.0006
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0418 0.1288
Echinococcus granulosus geminin 0.0334 0.3578 0.3574
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0048 0.0183
Onchocerca volvulus 0.0018 0.0017 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0112 0.1084 0.1074
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0412 0.1268
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0395 0.0389
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0483 0.1096
Echinococcus granulosus expressed protein 0.0017 0.0015 0.001
Trichomonas vaginalis esterase, putative 0.0035 0.0219 0.1036
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0097 0.0912 0.4504
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Echinococcus granulosus phd:f box containing protein 0.0032 0.0184 0.0178
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0689 0.0684
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1584 0.2567
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0904 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0048 0.0048
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0184 0.1018
Schistosoma mansoni apoferritin-2 0.0017 0.0015 0.0022
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0024 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.2011 0.6334
Brugia malayi beta-lactamase family protein 0.0035 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0219 0.0656
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0011 0.0005
Brugia malayi nuclear receptor NHR-88 0.002 0.0048 0.0048
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0017 0.0012
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0184 0.041
Echinococcus multilocularis Kelch repeat type 1 0.0194 0.2007 0.2003
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0112 0.1084 0.1079
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.1263 0.1253
Onchocerca volvulus Huntingtin homolog 0.0131 0.1291 0.6399
Entamoeba histolytica hypothetical protein 0.011 0.1055 0.5215
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0048 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.2011 0.6334
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Trypanosoma brucei unspecified product 0.004 0.0274 0.0831
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0184 0.0178
Schistosoma mansoni ets-related 0.0235 0.2461 0.5644
Loa Loa (eye worm) beta-lactamase 0.0035 0.0219 0.0208
Onchocerca volvulus 0.0035 0.0219 0.1036
Plasmodium vivax vivapain-2 0.0018 0.0017 0.0085
Mycobacterium tuberculosis Conserved protein 0.0035 0.0219 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Mycobacterium ulcerans beta-lactamase 0.0035 0.0219 0.0338
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0017 0.0012 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0219 0.0213
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0418 0.1288
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0418 0.0413
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0048 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.0042
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.0012 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0011 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0042
Schistosoma mansoni nuclear hormone receptor 0.002 0.0048 0.0097
Loa Loa (eye worm) ctsf protein 0.0018 0.0017 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0048
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0024 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0418 0.1288
Loa Loa (eye worm) hypothetical protein 0.0066 0.0563 0.0553
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0048 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0037
Entamoeba histolytica hypothetical protein 0.011 0.1055 0.5215
Echinococcus multilocularis ubiquitin specific protease 41 0.0112 0.1084 0.1079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0042 0.0152
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0012 0.0001
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0024 0.0039
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0418 0.2033
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.029 0.0883
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0219 0.1036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0208
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4355 0.4352
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0112 0.1084 0.1079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0063 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0001
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0013
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0414 0.4479 0.7295
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0048 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0099 0.0277
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0195 0.2011 0.6334
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0478 0.0762
Loa Loa (eye worm) fibroinase 0.0018 0.0017 0.0006
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0024 0.0039
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0184 0.0178
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0017 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Schistosoma mansoni P2X receptor subunit 0.0052 0.0407 0.0921
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0184 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0483 0.0769
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0414 0.4479 0.7295
Brugia malayi Bromodomain containing protein 0.0078 0.0695 0.0695
Schistosoma mansoni bromodomain containing protein 0.0066 0.0567 0.1289
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0219 0.3021
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0478 0.2333
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0418 0.1288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0063 0.0058
Schistosoma mansoni hypothetical protein 0.003 0.0162 0.036
Brugia malayi hypothetical protein 0.0161 0.1635 0.1635
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0024 0.0039
Echinococcus multilocularis muscleblind protein 1 0.0904 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0219 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Brugia malayi Smad1 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0478 0.0762
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0478 0.0473
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0017 0.0029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0017 0.0006
Echinococcus granulosus c-Jun N-terminal kinases 0.0192 0.1985 0.1981
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0219 0.0656
Leishmania major cathepsin L-like protease 0.0067 0.0573 0.1779
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0122 0.0116
Schistosoma mansoni cpg binding protein 0.0094 0.0878 0.2006
Entamoeba histolytica cysteine protease, putative 0.0018 0.0017 0.0029
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0195 0.2011 0.2003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.084 0.0835
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0478 0.2333
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0909 0.449
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0395 0.0389
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0099 0.0277
Brugia malayi serine/threonine-protein kinase plk-2 0.0195 0.2011 0.2011
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0184 0.0173
Echinococcus multilocularis zinc finger protein 0.0024 0.0089 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.3169 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Echinococcus multilocularis ferritin 0.0017 0.0015 0.001
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0122 0.0116
Schistosoma mansoni hypothetical protein 0.01 0.094 0.2149
Brugia malayi Stress-activated protein kinase jnk-1 0.0192 0.1985 0.1985
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0099 0.1275
Loa Loa (eye worm) hypothetical protein 0.0143 0.1426 0.1417
Schistosoma mansoni ferritin 0.0017 0.0015 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0024 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.084 0.1919
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0219 0.0656
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0395 0.0626
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0208
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0078 0.0697 0.0687
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.084 0.083
Schistosoma mansoni ferritin 0.0017 0.0015 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Schistosoma mansoni P2X receptor subunit 0.0052 0.0407 0.0921
Schistosoma mansoni smad1 5 8 and 0.0017 0.0011 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0017 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0199 0.2056 0.3339
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0219 0.1036
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0024 0.0039
Echinococcus multilocularis tumor protein p63 0.0355 0.3812 0.3809
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0024 0.0073
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0478 0.0468
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0018
Onchocerca volvulus 0.01 0.094 0.4644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0112 0.1084 0.2479
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0048 0.0097
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0042
Echinococcus granulosus FTZ F1 alpha 0.002 0.0048 0.0042
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0011 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.084 0.1919
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0418 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0239 0.0228
Schistosoma mansoni DNA polymerase eta 0.0109 0.1047 0.2393
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0219 0.0338
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.5315 0.5312
Brugia malayi MH1 domain containing protein 0.0017 0.0011 0.0011
Echinococcus granulosus cathepsin l1 0.0018 0.0017 0.0012
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0122 0.018
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0097
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0184 0.2514
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0162 0.0151
Echinococcus granulosus p2X purinoceptor 4 0.0052 0.0407 0.0401
Schistosoma mansoni apoferritin-2 0.0017 0.0015 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0528 0.0522
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0219 0.0338
Mycobacterium ulcerans lipase LipD 0.0035 0.0219 0.0338
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0048 0.0097
Brugia malayi hypothetical protein 0.003 0.0162 0.0162
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.0012 0.0006
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.026 0.0254
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0184 0.041
Schistosoma mansoni smad 0.0017 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.011 0.1055 0.2411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.058 0.1802
Echinococcus multilocularis lysine specific demethylase 5A 0.0121 0.1186 0.1181
Schistosoma mansoni ferritin 0.0017 0.0015 0.0022
Brugia malayi MH2 domain containing protein 0.025 0.263 0.263
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0017 0.0085
Toxoplasma gondii hypothetical protein 0.0027 0.0122 0.0652
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0418 0.2033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.084 0.1919
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0048 0.0097
Echinococcus multilocularis cysteine protease 0.0018 0.0017 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Mycobacterium ulcerans hypothetical protein 0.0035 0.0219 0.0338
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0017 0.0018
Toxoplasma gondii hypothetical protein 0.0048 0.036 0.2055
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0184 0.0178
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0184 0.0546
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0015 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Brugia malayi jmjC domain containing protein 0.0032 0.0184 0.0184
Brugia malayi jmjC domain containing protein 0.0121 0.1186 0.1186
Onchocerca volvulus 0.0018 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.003 0.0162 0.0151
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0017 0.0012 0.0001
Echinococcus granulosus dna polymerase kappa 0.0058 0.0478 0.0473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Echinococcus multilocularis caspase 2 0.003 0.0162 0.0156
Loa Loa (eye worm) hypothetical protein 0.004 0.0264 0.0254
Onchocerca volvulus 0.0018 0.0017 0.0029
Echinococcus multilocularis p2X purinoceptor 4 0.0052 0.0407 0.0401
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0017 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0801 0.0791
Schistosoma mansoni smad1 5 8 and 0.0017 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0001
Schistosoma mansoni cpg binding protein 0.0087 0.0801 0.1829
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0015 0.0006
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0162 0.0753
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.263 0.2621
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0219 0.0338
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 0.112
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0184 0.0546
Leishmania major DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0112 0.1084 0.5362
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0027 0.0021
Onchocerca volvulus 0.0018 0.0017 0.0029
Brugia malayi Bromodomain containing protein 0.0037 0.0238 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.058 0.1802
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0184 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Loa Loa (eye worm) hypothetical protein 0.0032 0.0184 0.0173
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0017 0.0012
Brugia malayi Cell death protein 3 precursor 0.003 0.0162 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0212 0.0206
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0123 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0088 0.0243
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0069 0.0592 0.3428
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.058 0.1802
Onchocerca volvulus 0.0087 0.0801 0.395
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0478 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0274 0.0831
Echinococcus granulosus caspase 2 0.003 0.0162 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0048
Echinococcus multilocularis p2X purinoceptor 4 0.0052 0.0407 0.0401
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.0012 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0042 0.0152
Brugia malayi beta-lactamase 0.0035 0.0219 0.0219
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0418 0.1288
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0483 0.0769
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0418 0.0413
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1405 0.4412
Onchocerca volvulus 0.0052 0.0404 0.1962
Schistosoma mansoni zinc finger protein 0.0024 0.0089 0.0192
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0184 0.1018
Plasmodium vivax JmjC domain containing protein 0.0032 0.0184 0.2514
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.0012 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.029 0.0883
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0042 0.0152
Trypanosoma brucei unspecified product 0.0058 0.0478 0.1478
Leishmania major hypothetical protein, conserved 0.0032 0.0184 0.0546
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1055 0.1049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.237 0.3851
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Brugia malayi MAP kinase sur-1 0.0053 0.0418 0.0418
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Onchocerca volvulus 0.0018 0.0017 0.0029
Schistosoma mansoni ferritin 0.0017 0.0015 0.0022
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0017 0.0085
Mycobacterium ulcerans hypothetical protein 0.0157 0.1584 0.2567
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0112 0.1084 0.5362
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0483 0.0477
Schistosoma mansoni tsg101-related 0.0119 0.1157 0.2648
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0048 0.0042
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0199 0.2056 0.3339
Entamoeba histolytica hypothetical protein 0.011 0.1055 0.5215
Mycobacterium ulcerans hypothetical protein 0.0018 0.0024 0.002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.029 0.0883
Onchocerca volvulus 0.0018 0.0017 0.0029
Schistosoma mansoni gabp alpha 0.0077 0.0689 0.1572
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0689 0.0684
Loa Loa (eye worm) hypothetical protein 0.0032 0.0184 0.0173
Mycobacterium tuberculosis Conserved protein 0.0035 0.0219 0.0338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0208
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0048
Echinococcus granulosus tumor protein p63 0.0355 0.3812 0.3809
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0048 0.0048
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0121 0.1186 0.1181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 0.112
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0123 0.0118
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0048 0.0183
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.058 0.2844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0184 0.0173
Brugia malayi beta-lactamase family protein 0.0035 0.0219 0.0219
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0017 0.0012 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Schistosoma mansoni kinase 0.0099 0.0938 0.2144
Echinococcus granulosus zinc finger protein 0.0024 0.0089 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1985 0.4551
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0122 0.161
Leishmania major DNA polymerase eta, putative 0.0069 0.0592 0.184
Echinococcus multilocularis geminin 0.0334 0.3578 0.3574
Toxoplasma gondii ABC1 family protein 0.0035 0.0219 0.1223
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0697 1
Entamoeba histolytica hypothetical protein 0.0024 0.0088 0.0383
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0017 0.0012 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.1263 0.2891
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0024 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0478 0.1478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0261 0.0255
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0697 0.159
Schistosoma mansoni coup transcription factor 0.002 0.0048 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0088 0.0383
Entamoeba histolytica hypothetical protein 0.0024 0.0088 0.0383
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0048 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0483 0.1492
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0017 0.0012
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0184 0.041
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0011 0.0005
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.0012 0.0006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0478 0.0762
Toxoplasma gondii cathepsin CPL 0.0018 0.0017 0.0034
Brugia malayi hypothetical protein 0.0025 0.0099 0.0099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0048 0.0097
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Brugia malayi hypothetical protein 0.0131 0.1291 0.1291
Leishmania major hypothetical protein, conserved 0.0035 0.0219 0.0656
Echinococcus multilocularis expressed protein 0.0017 0.0015 0.001
Entamoeba histolytica serine/threonine protein kinase, putative 0.0195 0.2011 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Leishmania major DNA polymerase eta, putative 0.0109 0.1047 0.3279
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0404 0.0915
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0063 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0219 0.049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.1084 0.5362
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0418 0.0948
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0046 0.0333 0.1019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.058 0.1802
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.1047 0.1047
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0048 0.0042
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0112 0.1084 0.3397
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.058 0.0575
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0017 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0478 0.0478
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0017 0.0029
Brugia malayi MH2 domain containing protein 0.0017 0.0011 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0109 0.1047 0.3279
Brugia malayi nuclear hormone receptor 0.002 0.0048 0.0048
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0478 0.1086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0042 0.0152
Trypanosoma cruzi DNA polymerase eta, putative 0.0109 0.1047 0.3279
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0184 0.041
Loa Loa (eye worm) hypothetical protein 0.0069 0.0592 0.0582
Brugia malayi hypothetical protein 0.011 0.1055 0.1055
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0024 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.084 0.0835
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0573 0.1779
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.2011 0.4611
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0042
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0017 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Brugia malayi jmjC domain containing protein 0.0032 0.0184 0.0184
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Echinococcus granulosus ETHE1 protein 0.0017 0.0012 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0219 0.1036
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0012 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0121 0.1186 0.2714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0573 0.1779
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0184 0.0178
Entamoeba histolytica hypothetical protein 0.0024 0.0088 0.0383
Echinococcus granulosus transcription factor Dp 1 0.0039 0.026 0.0254
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0088 0.0243
Schistosoma mansoni smad1 5 8 and 0.0017 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Echinococcus multilocularis cpg binding protein 0.0094 0.0878 0.0873
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0015 0.0056
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0048 0.0042
Echinococcus granulosus kelch ECH associated protein 1 like 0.0194 0.2001 0.1997
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0162 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0274 0.0831
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.5315 0.5312
Mycobacterium ulcerans lipoprotein LpqF 0.0199 0.2056 0.3339
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0418 0.1288
Giardia lamblia Kinase, PLK 0.0195 0.2011 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0478 0.1478
Schistosoma mansoni P2X receptor subunit 0.0052 0.0407 0.0921
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0483 0.0769
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0573 0.1779
Loa Loa (eye worm) hypothetical protein 0.0904 1 1
Brugia malayi Fli-1 protein 0.0235 0.2461 0.2461
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0024 0.0039
Echinococcus granulosus zinc phosphodiesterase 0.0017 0.0012 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0418 0.2033
Echinococcus multilocularis kelch ECH associated protein 1 0.0194 0.2001 0.1997
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0042
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0162 0.036
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0121 0.1186 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0152
Entamoeba histolytica hypothetical protein 0.0024 0.0088 0.0383
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0088 0.0243
Brugia malayi steroid hormone receptor 0.002 0.0048 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0042 0.0152
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0046 0.0333 0.1019
Leishmania major cathepsin L-like protease 0.0067 0.0573 0.1779
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0219 0.0338
Brugia malayi jmjC domain containing protein 0.0128 0.1263 0.1263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0027 0.0049
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0184 0.0546
Echinococcus multilocularis ETHE1 protein 0.0017 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0109 0.1047 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0048
Onchocerca volvulus 0.003 0.0162 0.0753
Echinococcus multilocularis kelch ECH associated protein 1 0.0194 0.2001 0.1997
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0015 0.0056
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0697 0.0692
Onchocerca volvulus 0.0018 0.0017 0.0029
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0037
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0015 0.0006
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0112 0.1084 0.1079
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2011 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0592 0.184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0219 0.049
Echinococcus multilocularis cysteine protease 0.0018 0.0017 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.094 0.094
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0395 0.0626
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0048 0.0037
Trichomonas vaginalis ferritin, putative 0.0017 0.0015 0.0019
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0112 0.1084 0.3397
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0042 0.0152
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.029 0.0883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0029
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0561 0.6136 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0219 0.0338
Loa Loa (eye worm) hypothetical protein 0.0032 0.0184 0.0173
Trichomonas vaginalis helicase, putative 0.002 0.0042 0.0152
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.1263 0.1258
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0483 0.2781
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0042
Schistosoma mansoni hypothetical protein 0.002 0.0045 0.009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0017 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0017 0.0012
Brugia malayi MH1 domain containing protein 0.0017 0.0011 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0418 0.2033
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0697 0.0692
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0418 0.24
Onchocerca volvulus 0.002 0.0048 0.0183
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0192 0.1985 0.1981
Trichomonas vaginalis hypothetical protein 0.0069 0.0602 0.2953
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.058 0.057
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0017 0.0029
Schistosoma mansoni ferritin light chain 0.0017 0.0015 0.0022
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0017 0.0085

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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