Detailed information for compound 674432

Basic information

Technical information
  • TDR Targets ID: 674432
  • Name: IVK/2008338
  • MW: 444.385 | Formula: C22H18F2N2O6
  • H donors: 0 H acceptors: 4 LogP: 3.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=CN(C=C(C1c1ccc(c(c1)[N+](=O)[O-])C)C(=O)OC)c1ccc(c(c1)F)F
  • InChi: 1S/C22H18F2N2O6/c1-12-4-5-13(8-19(12)26(29)30)20-15(21(27)31-2)10-25(11-16(20)22(28)32-3)14-6-7-17(23)18(24)9-14/h4-11,20H,1-3H3
  • InChiKey: JDIFLDUKAOSEJK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0007 0.0018
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0016 0.0007 0.0007
Trypanosoma brucei predicted zinc finger protein 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0259 0.0709
Echinococcus multilocularis SWI:SNF matrix associated 0.0894 0.3656 0.3656
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0146
Echinococcus granulosus lamin 0.0028 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0236 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.014 0.0384
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Loa Loa (eye worm) hypothetical protein 0.0112 0.0407 0.1113
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0013 0.0019
Schistosoma mansoni microtubule-associated protein tau 0.1483 0.6108 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0318 0.1261 1
Entamoeba histolytica hypothetical protein 0.0017 0.001 0.0106
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0013 0.0083
Schistosoma mansoni hypothetical protein 0.005 0.0146 0.0238
Trichomonas vaginalis esterase, putative 0.0077 0.0259 0.0709
Loa Loa (eye worm) hypothetical protein 0.0046 0.0131 0.036
Brugia malayi hypothetical protein 0.0135 0.05 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Onchocerca volvulus 0.0354 0.1412 0.3851
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0064 0.0488
Echinococcus granulosus zinc finger protein 0.0023 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0176
Brugia malayi hypothetical protein 0.025 0.098 0.268
Leishmania major DNA repair protein-like protein 0.0016 0.0007 0.0029
Echinococcus multilocularis ring finger protein 113a 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0027
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0018 0.0018
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0318 0.1261 0.345
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0047 0.0109
Chlamydia trachomatis DNA topoisomerase I 0.0894 0.3656 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0055 0.0152
Schistosoma mansoni hypothetical protein 0.0107 0.0385 0.063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0112 0.0407 0.0407
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0013 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.0407 0.0666
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0211 0.056
Onchocerca volvulus Huntingtin homolog 0.0135 0.05 0.1352
Echinococcus multilocularis tumor protein p63 0.2419 1 1
Leishmania major hypothetical protein, conserved 0.0077 0.0259 0.2036
Echinococcus multilocularis geminin 0.0182 0.0698 0.0698
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0318 0.1261 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0259 0.0709
Echinococcus multilocularis smad 0.0026 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0135 0.05 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0385
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0013 0.0013
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0016 0.0007 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0043 0.0318
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0591 0.1617
Echinococcus granulosus neuropeptide s receptor 0.0498 0.2009 0.2009
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni zinc finger protein 0.0016 0.0007 0.0011
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.001 0.0016
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.001 0.001
Trypanosoma cruzi WLM domain containing protein, putative 0.0318 0.1261 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0259 0.0709
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0007 0.0011
Brugia malayi hypothetical protein 0.0471 0.19 0.5197
Brugia malayi Neuralized family protein 0.0016 0.0007 0.0018
Trichomonas vaginalis set domain proteins, putative 0.0747 0.3046 0.8332
Echinococcus multilocularis cpg binding protein 0.0068 0.0222 0.0222
Brugia malayi SWIB/MDM2 domain containing protein 0.0894 0.3656 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0047 0.0047
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0007 0.0018
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0016 0.0007 0.0029
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0318 0.1261 0.1261
Trypanosoma brucei hypothetical protein, conserved 0.0318 0.1261 1
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.7746
Toxoplasma gondii ABC1 family protein 0.0077 0.0259 0.0692
Brugia malayi brahma associated protein 60 kDa 0.0894 0.3656 1
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0259 0.0709
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0028 0.0028
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0016 0.0007 0.0007
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0894 0.3656 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0894 0.3656 1
Leishmania major cytochrome p450-like protein 0.0025 0.0043 0.0318
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0894 0.3656 0.3656
Schistosoma mansoni hypothetical protein 0.0894 0.3656 0.5985
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0176
Brugia malayi RING zinc finger protein 0.0016 0.0007 0.0018
Schistosoma mansoni cpg binding protein 0.0063 0.0199 0.0326
Echinococcus granulosus Smad4 0.0026 0.0047 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0336 0.0336
Giardia lamblia GTOR 0.009 0.0312 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0146 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0591 0.1617
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0274 0.0448
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0471 0.19 0.5197
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0312 0.0854
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0013 0.0037
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0007 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0259 0.0259
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0047 0.0128
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0259 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0236 0.0645
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0064 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0041 0.0112
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0312 0.0312
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0211 0.7989
Brugia malayi CXXC zinc finger family protein 0.0063 0.0199 0.0545
Mycobacterium leprae Probable lipase LipE 0.0077 0.0259 0.5
Brugia malayi hypothetical protein 0.0026 0.0047 0.0127
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0047 0.0076
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0028 0.0077
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.2009 0.2009
Entamoeba histolytica protein kinase rad3, putative 0.0017 0.001 0.0106
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0043 0.0117
Onchocerca volvulus 0.0318 0.1261 0.3438
Loa Loa (eye worm) hypothetical protein 0.0157 0.0591 0.1617
Schistosoma mansoni mind bomb 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0018 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0077 0.0259 0.0709
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0043 0.0318
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0243 0.0398
Echinococcus granulosus serine protein kinase ATM 0.0017 0.001 0.001
Echinococcus granulosus dnaJ subfamily B 0.089 0.3642 0.3642
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0259 0.1248
Loa Loa (eye worm) hypothetical protein 0.0107 0.0385 0.1053
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0016 0.0007 0.0011
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0246 0.0246
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0211 0.1004
Brugia malayi MH1 domain containing protein 0.0026 0.0047 0.0128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.002 0.0138
Loa Loa (eye worm) hypothetical protein 0.025 0.098 0.268
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0259 0.0692
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.0007 0.0018
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0034 0.0094
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0318 0.1261 0.345
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0028 0.0028
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0236 0.0645
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0318 0.1261 0.345
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0048 0.0048
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi brahma associated protein 60 kDa 0.0894 0.3656 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0211 0.7989
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0013 0.0083
Brugia malayi MH2 domain containing protein 0.0026 0.0047 0.0128
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.002 0.0035
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Echinococcus multilocularis SWI:SNF matrix associated 0.0894 0.3656 0.3656
Echinococcus granulosus RING finger protein 185 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.005 0.0146 0.0398
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0064 0.0488
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0016 0.0007 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0018 0.0018
Echinococcus multilocularis lamin 0.0028 0.0055 0.0055
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0211 0.1655
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0199 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0176
Trichomonas vaginalis hypothetical protein 0.0016 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.001 0.0027
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0318 0.1261 0.3438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Loa Loa (eye worm) MH2 domain-containing protein 0.0379 0.1514 0.4142
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0007 0.0018
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.7746
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.001 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.002 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0049
Schistosoma mansoni smad1 5 8 and 0.0026 0.0047 0.0076
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Schistosoma mansoni ring finger protein 151 0.0016 0.0007 0.0011
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0013 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0259 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0089 0.0089
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Echinococcus granulosus GPCR family 2 0.005 0.0146 0.0146
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0312 0.0854
Echinococcus granulosus SWI:SNF matrix associated 0.0894 0.3656 0.3656
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0064 0.0064
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Echinococcus multilocularis zinc finger protein Ran binding 0.0318 0.1261 0.1261
Echinococcus multilocularis ring and YY1 binding protein 0.0318 0.1261 0.1261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0162 0.0444
Schistosoma mansoni hypothetical protein 0.005 0.0146 0.0238
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.05 0.1368
Loa Loa (eye worm) beta-lactamase 0.0077 0.0259 0.0709
Schistosoma mansoni peter pan-related 0.0016 0.0007 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0259 0.0709
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0312 0.2457
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0336 0.0902
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0312 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0018 0.0018
Schistosoma mansoni TRABID protein (C64 family) 0.0318 0.1261 0.2065
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0318 0.1261 0.3438
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0028 0.0046
Brugia malayi Pre-SET motif family protein 0.0657 0.267 0.7303
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0246 0.0246
Loa Loa (eye worm) brahma associated protein 0.0894 0.3656 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0236 0.0645
Leishmania major hypothetical protein, conserved 0.0318 0.1261 1
Onchocerca volvulus 0.0028 0.0055 0.0134
Leishmania major hypothetical protein, conserved 0.0318 0.1261 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0505 0.0827
Onchocerca volvulus 0.0318 0.1261 0.3438
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0259 0.2036
Chlamydia trachomatis SWIB complex protein 0.0894 0.3656 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0456 0.1232
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Brugia malayi PHD-finger family protein 0.0028 0.0058 0.0158
Mycobacterium tuberculosis Conserved protein 0.0077 0.0259 0.1248
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0259 0.0709
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0318 0.1261 1
Leishmania major hypothetical protein, unknown function 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0047 0.0346
Trypanosoma cruzi hypothetical protein, conserved 0.0318 0.1261 1
Brugia malayi RING finger protein 20 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0318 0.1261 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Brugia malayi Latrophilin receptor protein 2 0.005 0.0146 0.0398
Schistosoma mansoni smad1 5 8 and 0.0026 0.0047 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.002 0.0138
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.001 0.0016
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0047 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0336 0.055
Toxoplasma gondii ran binding protein 0.0318 0.1261 0.3438
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.002 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Schistosoma mansoni hypothetical protein 0.005 0.0146 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi beta-lactamase family protein 0.0077 0.0259 0.0709
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0146 0.0398
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0385
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0094 0.0725
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.002 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Leishmania major hypothetical protein, conserved 0.0318 0.1261 1
Schistosoma mansoni rnf5 0.0016 0.0007 0.0011
Trichomonas vaginalis ankyrin, putative 0.0016 0.0007 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Echinococcus multilocularis Smad4 0.0026 0.0047 0.0047
Echinococcus granulosus Zinc finger RanBP2 type 0.0318 0.1261 0.1261
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0016 0.0007 0.0029
Brugia malayi MH1 domain containing protein 0.0026 0.0047 0.0128
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.001 0.001
Schistosoma mansoni zinc finger protein 0.0023 0.0036 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0047 0.0346
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0274 0.0448
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0385 0.1053
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.001 0.0055
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.027
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0055 0.0152
Echinococcus multilocularis lamin dm0 0.0028 0.0055 0.0055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.002 0.0138
Echinococcus granulosus intermediate filament protein 0.0028 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0071 0.0236 0.1854
Brugia malayi MH2 domain containing protein 0.0026 0.0047 0.0128
Echinococcus multilocularis SWI:SNF matrix associated 0.0894 0.3656 0.3656
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0211 0.0211
Brugia malayi Pre-SET motif family protein 0.0095 0.0336 0.0919
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0027
Onchocerca volvulus Huntingtin homolog 0.0135 0.05 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0312 0.0854
Echinococcus multilocularis dnaJ subfamily B 0.089 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0152
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0162 0.0444
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0013 0.0013
Loa Loa (eye worm) Smad1 0.0026 0.0047 0.0128
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0013 0.0083
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0048 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.002 0.0038
Leishmania major hypothetical protein, conserved 0.0318 0.1261 1
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0318 0.1261 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0064 0.0176
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0016 0.0007 0.0029
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni lamin 0.0028 0.0055 0.0091
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0226 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.0033
Onchocerca volvulus 0.0063 0.0199 0.0528
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0013 0.0083
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0318 0.1261 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0259 0.0259
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0246 0.0672
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0318 0.1261 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0657 0.267 0.7303
Brugia malayi beta-lactamase family protein 0.0077 0.0259 0.0709
Onchocerca volvulus 0.0077 0.0259 0.0692
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.2009 0.2009
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.002 0.0056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Toxoplasma gondii FATC domain-containing protein 0.0017 0.001 0.0009
Onchocerca volvulus 0.0318 0.1261 0.3438
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Plasmodium vivax SET domain protein, putative 0.0095 0.0336 0.0902
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0894 0.3656 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0064 0.0105
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0259 0.1248
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Onchocerca volvulus 0.0051 0.0152 0.0397
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.7746
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0064 0.0488
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0016 0.0007 0.0007
Schistosoma mansoni smad 0.0026 0.0047 0.0076
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0007 0.0018
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0017 0.001 0.0106
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0005
Onchocerca volvulus 0.0894 0.3656 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0047 0.0076
Trypanosoma brucei ring finger containing protein 0.0016 0.0007 0.0029
Onchocerca volvulus 0.0077 0.0259 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni survival motor neuron protein 0.0051 0.0152 0.0248
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0043 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0202 0.0202
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0089 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0146 0.0398
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0259 0.0709
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0047 0.0109
Onchocerca volvulus 0.0471 0.19 0.5188
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0318 0.1261 1
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0152 0.0415
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0312 0.0511
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0312 0.2457
Echinococcus granulosus cpg binding protein 0.0068 0.0222 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0162 0.0444
Schistosoma mansoni fusion 0.0318 0.1261 0.2065
Brugia malayi B-box zinc finger family protein 0.0016 0.0007 0.0018
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0077
Schistosoma mansoni zinc finger protein 0.0318 0.1261 0.2065
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0312 0.0854
Loa Loa (eye worm) hypothetical protein 0.0064 0.0205 0.0562
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0259 0.0709
Echinococcus granulosus cell growth regulator with ring finger domain 0.0016 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0068 0.0222 0.0364
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0047 0.0109
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0028 0.0028
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0028 0.0046
Echinococcus multilocularis musashi 0.0028 0.0055 0.0055
Onchocerca volvulus 0.0028 0.0055 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Brugia malayi hypothetical protein 0.0017 0.0009 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0013 0.0037
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0236 0.0645
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0146 0.0146
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0259 1
Echinococcus granulosus microtubule associated protein 2 0.1483 0.6108 0.6108
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0176
Mycobacterium ulcerans hypothetical protein 0.0077 0.0259 1
Echinococcus granulosus lamin dm0 0.0028 0.0055 0.0055
Brugia malayi YY1-associated factor 2 0.0318 0.1261 0.345
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0025 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0259 0.0424
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0259 0.1248
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0013 0.0022
Trypanosoma cruzi hypothetical protein 0.0016 0.0007 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0108
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Trypanosoma brucei DNA repair protein, putative 0.0016 0.0007 0.0029
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0211 0.0211
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.002 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0385
Mycobacterium tuberculosis Conserved protein 0.0077 0.0259 0.1248
Loa Loa (eye worm) hypothetical protein 0.0077 0.0259 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0318 0.1261 0.345
Giardia lamblia Kinase, NEK 0.0016 0.0007 0.00000053575
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0259 1
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Mycobacterium tuberculosis Conserved protein 0.0077 0.0259 0.1248
Brugia malayi isocitrate dehydrogenase 0.0018 0.0013 0.0037
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0318 0.1261 0.345
Mycobacterium ulcerans beta-lactamase 0.0077 0.0259 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0894 0.3656 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.002 0.0448
Leishmania major hypothetical protein, conserved 0.0026 0.0047 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi Cytochrome P450 family protein 0.0025 0.0043 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0258 0.0705
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.014 0.0384
Echinococcus multilocularis 0.0016 0.0007 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0013 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0259 0.5
Schistosoma mansoni hypothetical protein 0.0894 0.3656 0.5985
Onchocerca volvulus 0.0077 0.0259 0.0692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0318 0.1261 0.345
Echinococcus granulosus ring finger protein 113a 0.0016 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0259 0.0709
Brugia malayi Zinc finger protein 183 homolog 0.0016 0.0007 0.0018
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0016 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0202 0.0202
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.7746
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.2009 0.2009
Schistosoma mansoni hypothetical protein 0.0318 0.1261 0.2065
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0013 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.0318 0.1261 1
Trypanosoma cruzi hypothetical protein 0.0016 0.0007 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0049
Echinococcus multilocularis ring finger protein 170 0.0016 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0379 0.1514 0.4142
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0016 0.0007 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.002 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0312 0.2457
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0259 0.2036
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0116 0.0896
Onchocerca volvulus 0.0747 0.3046 0.8329
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0055 0.0152
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0016 0.0007 0.0007
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.001 0.001
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Echinococcus granulosus geminin 0.0182 0.0698 0.0698
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0047 0.0047
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0064 0.0488
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0016 0.0007 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.0354 0.1412 0.2312
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Schistosoma mansoni Smad4 0.0026 0.0047 0.0076
Schistosoma mansoni cpg binding protein 0.0068 0.0222 0.0364
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Leishmania major hypothetical protein 0.0016 0.0007 0.0029
Leishmania major hypothetical protein, conserved 0.0318 0.1261 1
Echinococcus multilocularis RING finger protein 185 0.0016 0.0007 0.0007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0071 0.0236 0.1854
Loa Loa (eye worm) hypothetical protein 0.0077 0.0259 0.0709
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.002 0.002
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0007 0.0018
Brugia malayi Cytochrome P450 family protein 0.0025 0.0043 0.0117
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Loa Loa (eye worm) RiNg Finger protein family member 0.0016 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0894 0.3656 0.5985
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Schistosoma mansoni hypothetical protein 0.0021 0.0025 0.0041
Toxoplasma gondii exonuclease III APE 0.0019 0.002 0.0038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.089 0.3642 0.5962
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni hypothetical protein 0.0182 0.0698 0.1143
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0034 0.0034
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0259 0.1248
Echinococcus granulosus ring and YY1 binding protein 0.0318 0.1261 0.1261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0112 0.0407 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.016 0.0438
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.001 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.014 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0217 0.0593
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0043 0.0946
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0318 0.1261 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0243 0.0243
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0312 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.002 0.0038
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0226 0.0617
Echinococcus multilocularis microtubule associated protein 2 0.1483 0.6108 0.6108
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0894 0.3656 0.3656
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0318 0.1261 0.3438
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.001 0.0055
Schistosoma mansoni intermediate filament proteins 0.0028 0.0055 0.0091
Trichomonas vaginalis ankyrin, putative 0.0016 0.0007 0.0018
Schistosoma mansoni brg-1 associated factor 0.0894 0.3656 0.5985
Brugia malayi beta-lactamase 0.0077 0.0259 0.0709
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0318 0.1261 0.1261
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.098 0.098
Mycobacterium ulcerans lipase LipD 0.0077 0.0259 1
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0211 0.0346
Echinococcus granulosus smad 0.0026 0.0047 0.0047
Schistosoma mansoni zinc finger protein 0.0015 0.0003 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Giardia lamblia Ser/Thr protein kinase 0.0016 0.0007 0.00000053575
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0048 0.0048
Onchocerca volvulus 0.0095 0.0336 0.0902
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0064 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0259 0.2036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.016 0.0438
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0873 0.3569 0.3569
Loa Loa (eye worm) hypothetical protein 0.0071 0.0233 0.0638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0013 0.0013
Trypanosoma cruzi target of rapamycin kinase 3 0.0071 0.0236 0.1854
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0013 0.0019
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0007 0.0018
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0217 0.0576
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0259 0.0709
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0246 0.0672
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0043 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0016 0.0007 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0013 0.0019
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0017
Brugia malayi Bromodomain containing protein 0.0038 0.0099 0.027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.002 0.0448
Loa Loa (eye worm) hypothetical protein 0.0318 0.1261 0.345
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0043 0.0117
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0016 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0073 0.0243 0.0398
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0591 0.1617
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.002 0.0056
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0491 0.1983 1
Schistosoma mansoni hypothetical protein 0.005 0.0146 0.0238
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0312 0.2457
Echinococcus granulosus survival motor neuron protein 1 0.025 0.098 0.098
Schistosoma mansoni hypothetical protein 0.0182 0.0698 0.1143
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0013 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0047 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni peter pan-related 0.0016 0.0007 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0318 0.1261 0.345
Schistosoma mansoni hypothetical protein 0.0051 0.0152 0.0248
Echinococcus multilocularis zinc finger protein 0.0023 0.0036 0.0036
Echinococcus multilocularis GPCR, family 2 0.005 0.0146 0.0146
Brugia malayi Zinc finger, C2H2 type family protein 0.0016 0.0007 0.0018
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0211 0.0346
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0312 0.2457
Brugia malayi intermediate filament protein 0.0028 0.0055 0.0152
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0894 0.3656 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0312 0.2457
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0189 0.0518
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0002 0.0004
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0318 0.1261 0.345
Brugia malayi Bromodomain containing protein 0.0079 0.0266 0.0727
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.002 0.0056
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0894 0.3656 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0259 0.1248
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0047 0.0128
Schistosoma mansoni bromodomain containing protein 0.0067 0.0217 0.0356
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0316 0.0316
Schistosoma mansoni lamin 0.0028 0.0055 0.0091
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0064 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) RING finger protein 20 0.0016 0.0007 0.0018
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0029
Trichomonas vaginalis ankyrin, putative 0.0016 0.0007 0.0018
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0211 0.7989
Brugia malayi Smad1 0.0026 0.0047 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0894 0.3656 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0018 0.0018
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0894 0.3656 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0336 0.055
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.0407 0.0666
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0318 0.1261 0.1261
Loa Loa (eye worm) hypothetical protein 0.0354 0.1412 0.3862
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0016 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0181 0.0496
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0318 0.1261 0.3438
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0018 0.0031
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0007 0.0018
Brugia malayi hypothetical protein 0.0073 0.0243 0.0666
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0176
Brugia malayi MH2 domain containing protein 0.0379 0.1514 0.4142
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0047 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni RNA binding protein 0.0318 0.1261 0.2065
Giardia lamblia Protein 21.1 0.0016 0.0007 0.00000053575
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0385
Echinococcus granulosus zinc finger protein Ran binding 0.0318 0.1261 0.1261
Trypanosoma cruzi WLM domain containing protein, putative 0.0318 0.1261 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0312 0.0854
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0007 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0259 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0011
Echinococcus granulosus ring finger protein 170 0.0016 0.0007 0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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