Detailed information for compound 712067

Basic information

Technical information
  • TDR Targets ID: 712067
  • Name: methyl 2-methyl-3-(naphthalen-2-ylsulfonylami no)benzoate
  • MW: 355.408 | Formula: C19H17NO4S
  • H donors: 1 H acceptors: 3 LogP: 3.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cccc(c1C)NS(=O)(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C19H17NO4S/c1-13-17(19(21)24-2)8-5-9-18(13)20-25(22,23)16-11-10-14-6-3-4-7-15(14)12-16/h3-12,20H,1-2H3
  • InChiKey: JJAMVGONIWHGNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-methyl-3-(2-naphthylsulfonylamino)benzoate
  • 2-methyl-3-(2-naphthylsulfonylamino)benzoic acid methyl ester
  • ZINC01111066

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.063 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.4102 0.7951 0.795
Loa Loa (eye worm) phosphatidylinositol 3 0.0333 0.063 0.063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0333 0.063 0.0629
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Onchocerca volvulus 0.0035 0.0051 0.0808
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0012 0.0006 0.0568
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0012 0.0006 0.0095
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0063 0.0106 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0051 0.0808
Mycobacterium ulcerans beta-lactamase 0.0035 0.0051 0.4804
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0031 0.0031
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0333 0.063 0.0629
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0157 0.0156
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5158 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0333 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0012 0.0006 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.3082 0.5969 0.5969
Schistosoma mansoni cpg binding protein 0.0028 0.0038 0.0037
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0012 0.0006 0.0568
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5158 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0005 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0002 0.0002
Schistosoma mansoni serine/threonine kinase 0.0012 0.0006 0.0006
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0333 0.063 0.0629
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0063 0.0106 0.1681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0157 0.0157
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0089 0.0088
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Echinococcus granulosus Glutaredoxin protein 5 0.0023 0.0028 0.0027
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0333 0.063 0.0629
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Schistosoma mansoni coup transcription factor 0.001 0.0002 0.0002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0333 0.063 0.0629
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0063 0.0106 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0333 0.063 0.063
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0002
Toxoplasma gondii ABC1 family protein 0.0035 0.0051 0.0068
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0012 0.0006 0.0568
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0012 0.0006 0.0095
Leishmania major phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.5158 1 1
Schistosoma mansoni immunophilin 0.0063 0.0106 0.0106
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0002
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0016 0.0016
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0012 0.0006 0.0568
Echinococcus multilocularis protein kinase c iota type 0.0012 0.0006 0.0006
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.0032 0.0032
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0012 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.4102 0.7951 0.795
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0016 0.0253
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0012 0.0006 0.0006
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0333 0.063 0.063
Trichomonas vaginalis fk506-binding protein, putative 0.0063 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0333 0.063 0.0629
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0333 0.063 0.063
Loa Loa (eye worm) phosphatidylinositol 3 0.5158 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0012 0.0006 0.0568
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0061 0.0061
Loa Loa (eye worm) AGC/NDR protein kinase 0.0012 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.173 0.3343 0.3342
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0333 0.063 0.063
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0012 0.0006 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0012 0.0006 0.0095
Echinococcus granulosus serine threonine protein kinase nrc 0.0023 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.0753 0.0753
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0002 0.0002
Loa Loa (eye worm) beta-lactamase 0.0035 0.0051 0.0051
Schistosoma mansoni fkbp-rapamycin associated protein 0.0976 0.1878 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.173 0.3343 0.3342
Trichomonas vaginalis PIKK family atypical protein kinase 0.2781 0.5384 0.5384
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0239 0.0239
Mycobacterium ulcerans hypothetical protein 0.0035 0.0051 0.4804
Trichomonas vaginalis PIKK family atypical protein kinase 0.2785 0.5392 0.5392
Loa Loa (eye worm) phosphatidylinositol 3 0.0333 0.063 0.063
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.0032 0.0032
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.1051 0.2025 0.2025
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0016 0.0016
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0012 0.0006 0.0568
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0333 0.063 0.063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Echinococcus multilocularis fk506 binding protein 0.0063 0.0106 0.0106
Echinococcus granulosus tar DNA binding protein 0.0132 0.0239 0.0239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0002 0.0002
Entamoeba histolytica protein kinase, putative 0.0037 0.0055 0.0055
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0006 0.0006
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0089 0.0089
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0051 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Brugia malayi Protein kinase domain containing protein 0.0012 0.0006 0.0006
Echinococcus granulosus NDR protein kinase 0.0012 0.0006 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0012 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0333 0.063 0.0629
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0006 0.0006
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0333 0.063 0.063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0157 0.0156
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0333 0.063 0.0629
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5158 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0032 0.0032
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0006 0.0006
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0333 0.063 0.0629
Entamoeba histolytica hypothetical protein 0.0333 0.063 0.0629
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0239 0.0239
Onchocerca volvulus 0.0028 0.0038 0.059
Brugia malayi cytochrome P450 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0035 0.0051 0.0808
Brugia malayi ecdysteroid receptor 0.001 0.0002 0.0002
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0032 0.0032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Brugia malayi hypothetical protein 0.0024 0.0031 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Echinococcus granulosus serine:threonine protein kinase N2 0.0012 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0333 0.063 0.0629
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0012 0.0006 0.0095
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0023 0.0028 0.0027
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0754 0.1448 0.1448
Schistosoma mansoni cpg binding protein 0.0029 0.0041 0.004
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0012 0.0006 0.0006
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0333 0.063 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0012 0.0006 0.0568
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0063 0.0106 0.0106
Echinococcus granulosus dnaJ subfamily B 0.0396 0.0753 0.0753
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0976 0.1878 0.1878
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.063 0.063
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0051 0.4804
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0063 0.0106 0.0106
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5158 1 1
Brugia malayi beta-lactamase family protein 0.0035 0.0051 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0002 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0002 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0239 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.3051 0.5909 0.5909
Loa Loa (eye worm) phosphatidylinositol 3 0.0333 0.063 0.063
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0333 0.063 0.0629
Brugia malayi Cytochrome P450 family protein 0.0012 0.0006 0.0006
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0333 0.063 0.063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0157 0.0157
Brugia malayi FAT domain containing protein 0.0754 0.1448 0.1448
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0031 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.3082 0.5969 0.5969
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0031 0.0031
Brugia malayi p70 ribosomal S6 kinase beta 0.0035 0.005 0.005
Leishmania major phosphatidylinositol kinase related protein, putative 0.0333 0.063 0.0629
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0333 0.063 0.0629
Echinococcus multilocularis Zinc finger, PHD finger 0.0333 0.063 0.063
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0012 0.0006 0.0568
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0063 0.0106 0.0106
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0063 0.0106 0.0106
Schistosoma mansoni immunophilin 0.0063 0.0106 0.0106
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1087 0.2094 0.2817
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Brugia malayi Hr1 repeat family protein 0.0012 0.0006 0.0006
Entamoeba histolytica protein kinase 2, putative 0.0023 0.0028 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0051 0.0808
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.173 0.3343 0.3342
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0002 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0157 0.0157
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0016 0.0253
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0976 0.1878 0.1878
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0002 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5158 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Toxoplasma gondii FATC domain-containing protein 0.0976 0.1878 0.2526
Trichomonas vaginalis PIKK family atypical protein kinase 0.173 0.3343 0.3342
Schistosoma mansoni hypothetical protein 0.004 0.0061 0.0061
Onchocerca volvulus 0.0333 0.063 1
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0023 0.0028 0.0439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0086 0.0115
Echinococcus multilocularis serine threonine protein kinase 0.0012 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0239 0.0239
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0002
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0012 0.0006 0.0006
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0063 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.1087 0.2094 0.2094
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0643 0.1232 0.1231
Plasmodium vivax hypothetical protein, conserved 0.0333 0.063 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0023 0.0028 0.0439
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Entamoeba histolytica protein kinase, putative 0.0037 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.004 0.0061 0.0061
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0976 0.1878 0.1878
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0012 0.0006 0.0095
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0016
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0333 0.063 0.063
Brugia malayi TAR-binding protein 0.0132 0.0239 0.0239
Schistosoma mansoni cpg binding protein 0.0029 0.0041 0.004
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0333 0.063 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.4404 0.8535 0.8535
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0333 0.063 0.0629
Echinococcus granulosus Protein kinase C brain isozyme 0.0012 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0333 0.063 0.063
Onchocerca volvulus 0.0035 0.0051 0.0808
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0333 0.063 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0976 0.1878 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Trichomonas vaginalis PIKK family atypical protein kinase 0.2785 0.5392 0.5392
Trichomonas vaginalis conserved hypothetical protein 0.0643 0.1232 0.1231
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0333 0.063 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.4102 0.7951 0.795
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0031 0.0031
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0333 0.063 0.0629
Trypanosoma brucei rac serine-threonine kinase, putative 0.0037 0.0055 0.0055
Echinococcus granulosus nervana 2 0.0023 0.0028 0.0027
Giardia lamblia Hypothetical protein 0.0333 0.063 0.0629
Echinococcus multilocularis cpg binding protein 0.0029 0.0041 0.004
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0239 0.0239
Schistosoma mansoni atypical protein kinase C 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0416 0.6606
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0006 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0035 0.0051 0.0808
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0333 0.063 0.0629
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5158 1 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0012 0.0006 0.0006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0051 0.0051
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.0032 0.0032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.0002
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2142 0.4144 0.4144
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0063 0.0106 0.0106
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0012 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0333 0.063 1
Leishmania major cytochrome p450-like protein 0.0012 0.0006 0.0006
Echinococcus granulosus microtubule associated protein 2 0.0667 0.1278 0.1278
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0333 0.063 0.0629
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.173 0.3343 0.3342
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5158 1 1
Brugia malayi beta-lactamase 0.0035 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0024 0.0031 0.0031
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0006 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0016 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.2781 0.5384 0.5384
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.3082 0.5969 0.5969
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0051 0.4804
Echinococcus multilocularis 0.0333 0.063 0.063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.173 0.3343 0.3343
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0012 0.0006 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0051 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.1278 0.1278
Entamoeba histolytica protein kinase rad3, putative 0.0976 0.1878 0.1878
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0051 0.0051
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0063 0.0106 0.1681
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0016 0.0021
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0032 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0239 0.0239
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0051 0.0808
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0012 0.0006 0.0568
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0023 0.0028 0.0027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0051 0.0051
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0006 0.0568
Echinococcus multilocularis 0.0012 0.0006 0.0006
Leishmania major fk506-binding protein 1-like protein 0.0063 0.0106 0.0106
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0006 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5158 1 1
Leishmania major cytochrome p450-like protein 0.0012 0.0006 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0012 0.0006 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0333 0.063 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0063 0.0106 0.0106
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0063 0.0106 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0976 0.1878 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0976 0.1878 0.1878
Onchocerca volvulus 0.001 0.0002 0.0033
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0333 0.063 0.0629
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0063 0.0106 0.0106
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0239 0.0239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0333 0.063 0.0629
Loa Loa (eye worm) phosphatidylinositol kinase 0.0333 0.063 0.063
Schistosoma mansoni immunophilin 0.0054 0.0089 0.0089
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0002 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Trypanosoma cruzi target of rapamycin kinase 3 0.4107 0.7959 0.7959
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0051 0.0808
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0063 0.0106 0.0106
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0011 0.001
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0012 0.0006 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.173 0.3343 0.3342
Toxoplasma gondii AGC kinase 0.0035 0.005 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.063 0.063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0016
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0012 0.0006 0.0568
Mycobacterium tuberculosis Conserved hypothetical protein 0.0333 0.063 1
Leishmania major hypothetical protein, unknown function 0.0333 0.063 0.0629
Brugia malayi Cytochrome P450 family protein 0.0012 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.4102 0.7951 0.795
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0006 0.0008
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.173 0.3343 0.3342
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0333 0.063 0.0629
Loa Loa (eye worm) phosphatidylinositol 3 0.173 0.3343 0.3342
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0333 0.063 0.0847
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0012 0.0006 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.173 0.3343 0.3342
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0012 0.0006 0.0095
Echinococcus granulosus protein kinase C gamma type 0.0012 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0333 0.063 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.3348 0.6486 0.6486
Echinococcus granulosus protein kinase c iota type 0.0012 0.0006 0.0006
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0089 0.0089
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.173 0.3343 0.3342
Trichomonas vaginalis immunophilin, putative 0.0063 0.0106 0.0106
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0012 0.0006 0.0095
Leishmania major phosphatidylinositol 3-kinase, putative 0.173 0.3343 0.3342
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0089 0.0089
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.5158 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0031 0.0485
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0016
Brugia malayi Cytochrome P450 family protein 0.0054 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0012 0.0006 0.0568
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2439 0.472 0.472
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0063 0.0106 0.0106
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0976 0.1878 0.1878
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0333 0.063 0.0629
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0333 0.063 0.0629
Leishmania major hypothetical protein, conserved 0.0035 0.0051 0.0051
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0976 0.1878 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0333 0.063 0.0629
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0063 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.2785 0.5392 0.5392
Loa Loa (eye worm) hypothetical protein 0.0976 0.1878 0.1878
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0333 0.063 0.0847
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0063 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0333 0.063 0.0847
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0239 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0976 0.1878 0.1878
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0333 0.063 0.063
Brugia malayi beta-lactamase family protein 0.0035 0.0051 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0051 0.0051
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0035 0.005 0.005
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0012 0.0006 0.0095
Entamoeba histolytica hypothetical protein 0.0333 0.063 0.0629
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0051 0.0051
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0012 0.0006 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.4102 0.7951 0.795
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0333 0.063 0.0629
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0333 0.063 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0012 0.0006 0.0095
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0023 0.0028 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0051 0.0808
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.0002
Brugia malayi isocitrate dehydrogenase 0.0017 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0754 0.1448 0.1448
Trypanosoma cruzi Protein kinase B 0.0025 0.0032 0.0032
Mycobacterium ulcerans lipase LipD 0.0035 0.0051 0.4804
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Brugia malayi steroid hormone receptor 0.001 0.0002 0.0002
Loa Loa (eye worm) FKBP5 protein 0.0063 0.0106 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0002 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0012 0.0006 0.0095
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0006 0.0006
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0063 0.0106 0.0106
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.063 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0333 0.063 0.063
Echinococcus granulosus nervana 2 0.0023 0.0028 0.0027
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0333 0.063 0.0629
Leishmania major phosphatidylinositol 4-kinase, putative 0.0333 0.063 0.0629
Mycobacterium leprae putative cytochrome p450 0.0012 0.0006 0.0095
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0012 0.0006 0.0568
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0333 0.063 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0012 0.0006 0.0095
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0063 0.0106 0.0106
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0051 0.0808
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0333 0.063 0.0629
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0012 0.0006 0.0568
Leishmania major peptidylprolyl isomerase-like protein 0.0063 0.0106 0.0106
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0333 0.063 0.0629
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0157 0.0157
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0023 0.0028 0.0028
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0012 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1384 0.2671 0.2671
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0754 0.1448 0.1448
Entamoeba histolytica hypothetical protein 0.004 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.1087 0.2094 0.2094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0051 0.0051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0976 0.1878 0.1878
Schistosoma mansoni cytochrome P450 0.0012 0.0006 0.0006
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0333 0.063 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.063 0.063
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0012 0.0006 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.5158 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0333 0.063 0.0629
Loa Loa (eye worm) hypothetical protein 0.0333 0.063 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.346 0.6702 0.6702
Toxoplasma gondii target of rapamycin (TOR), putative 0.3836 0.7433 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0006 0.0006
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0006 0.0006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0106 0.0106
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0333 0.063 0.0629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0157 0.0156
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0333 0.063 0.063
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0333 0.063 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2785 0.5392 0.5392
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.7433 0.7433
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1232 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.2781 0.5384 0.5384
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0333 0.063 0.0629
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0333 0.063 0.0629
Giardia lamblia Kinase, AGC PKA 0.0023 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0754 0.1448 0.1448
Plasmodium vivax hypothetical protein 0.0333 0.063 1
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0009 0 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0106 0.0106
Brugia malayi CXXC zinc finger family protein 0.0028 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.173 0.3343 0.3342
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0106 0.0106
Echinococcus granulosus serine protein kinase ATM 0.0976 0.1878 0.1878
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0157 0.0157
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0012 0.0006 0.0568
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0002
Brugia malayi Cytochrome P450 family protein 0.0012 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0333 0.063 0.0629
Loa Loa (eye worm) cytochrome P450 0.0012 0.0006 0.0006
Echinococcus multilocularis Glutaredoxin protein 5 0.0023 0.0028 0.0027
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0754 0.1448 0.1448
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.3051 0.5909 0.5909
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0016 0.0016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1582 0.3056 0.3056
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0031 0.0041
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.0055 0.0055
Loa Loa (eye worm) AGC/PKN protein kinase 0.0012 0.0006 0.0006
Entamoeba histolytica protein kinase, putative 0.0035 0.005 0.005
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.1278 0.1278
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0333 0.063 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0012 0.0006 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0012 0.0006 0.0095
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0012 0.0006 0.0568
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0333 0.063 0.0847
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0038 0.0037
Echinococcus multilocularis nervana 2 0.0023 0.0028 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.173 0.3343 0.3342
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0333 0.063 0.0629
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5158 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0333 0.063 0.0629
Giardia lamblia Phosphatidylinositol 4-kinase 0.0333 0.063 0.0629
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0016 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0002 0.0033
Brugia malayi hypothetical protein 0.0016 0.0014 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0051 0.0051
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0016 0.0253
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0009 0 0.5
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0002
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0051 0.0051
Echinococcus multilocularis serine protein kinase ATM 0.0976 0.1878 0.1878
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0051 0.0051
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0028 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.063 0.063
Leishmania major cytochrome p450-like protein 0.0012 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0396 0.0753 0.0753
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0012 0.0006 0.0568
Echinococcus multilocularis serine:threonine protein kinase 38 0.0012 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.004 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0333 0.063 0.0629
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0002
Onchocerca volvulus 0.0035 0.0051 0.0808
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0012 0.0006 0.0006
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0333 0.063 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.173 0.3343 0.3342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0976 0.1878 0.1878
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0333 0.063 0.0629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.063 0.063
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0643 0.1232 0.1232
Entamoeba histolytica hypothetical protein 0.004 0.0061 0.0061
Onchocerca volvulus 0.0333 0.063 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.173 0.3343 0.3342
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0333 0.063 0.063
Echinococcus multilocularis nervana 2 0.0023 0.0028 0.0027
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0002
Leishmania major phosphatidylinositol kinase, putative 0.0333 0.063 0.0629
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0098 0.0098
Brugia malayi hypothetical protein 0.004 0.0061 0.0061
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5158 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0051 0.0808
Brugia malayi Protein kinase domain containing protein 0.0037 0.0055 0.0055
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0063 0.0106 0.0106
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0055 0.0055
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0051 0.0808
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0333 0.063 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0051 0.0051
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0012 0.0006 0.0095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0157 0.0157
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0031 0.0485
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0333 0.063 0.0629
Mycobacterium leprae Conserved hypothetical protein 0.0012 0.0006 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0051 0.0051
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0976 0.1878 0.1878
Echinococcus granulosus FTZ F1 alpha 0.001 0.0002 0.0002
Entamoeba histolytica protein kinase, putative 0.0012 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0333 0.063 0.0629
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0333 0.063 0.063
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5158 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Mycobacterium leprae Probable lipase LipE 0.0035 0.0051 0.0808
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0333 0.063 0.0629
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0012 0.0006 0.0568
Loa Loa (eye worm) RNA binding protein 0.0132 0.0239 0.0239
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0002 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4107 0.7959 0.7959
Trichomonas vaginalis esterase, putative 0.0035 0.0051 0.0051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Giardia lamblia GTOR 0.5158 1 1
Brugia malayi protein kinase C II. 0.0012 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0333 0.063 0.0629
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0333 0.063 0.0629
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0333 0.063 0.0847
Mycobacterium tuberculosis Conserved protein 0.0035 0.0051 0.0808
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0333 0.063 0.063
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0061 0.0061
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0016 0.0021
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0333 0.063 0.063
Echinococcus granulosus cpg binding protein 0.0029 0.0041 0.004
Brugia malayi RNA binding protein 0.0132 0.0239 0.0239
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4107 0.7959 0.7959
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0012 0.0006 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0976 0.1878 0.1878
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0012 0.0006 0.0568

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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