Detailed information for compound 730491

Basic information

Technical information
  • TDR Targets ID: 730491
  • Name: 2-furan-2-yl-N-(furan-2-ylmethyl)-4-phenylsul fonyl-1,3-oxazol-5-amine
  • MW: 370.379 | Formula: C18H14N2O5S
  • H donors: 1 H acceptors: 3 LogP: 3.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1nc(oc1NCc1ccco1)c1ccco1)c1ccccc1
  • InChi: 1S/C18H14N2O5S/c21-26(22,14-7-2-1-3-8-14)18-17(19-12-13-6-4-10-23-13)25-16(20-18)15-9-5-11-24-15/h1-11,19H,12H2
  • InChiKey: AVUDBVVAYWAMLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-furyl)-N-(2-furylmethyl)-4-phenylsulfonyl-oxazol-5-amine
  • 2-(2-furyl)-N-(2-furylmethyl)-4-phenylsulfonyl-5-oxazolamine
  • 2-furylmethyl-[2-(2-furyl)-4-phenylsulfonyl-oxazol-5-yl]amine
  • CBKinase1_021940
  • ZINC01052841
  • 2-(2-furyl)-N-(2-furylmethyl)-4-(phenylsulfonyl)-1,3-oxazol-5-amine
  • MLS000051123
  • SMR000079021
  • CBKinase1_009540

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi major facilitator superfamily protein 0.0043 0.0136 0.0148
Brugia malayi MH2 domain containing protein 0.0043 0.0137 0.0149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0099 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.0115 0.0125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.022 0.0239
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trichomonas vaginalis rotamase, putative 0.0038 0.0108 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Brugia malayi hypothetical protein 0.0026 0.0036 0.0039
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Loa Loa (eye worm) hypothetical protein 0.0044 0.014 0.0398
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0108 0.0307
Schistosoma mansoni ferritin light chain 0.0045 0.0144 0.0157
Echinococcus granulosus synaptic vesicle 2 protein 0.0043 0.0136 0.0136
Mycobacterium tuberculosis Conserved protein 0.0257 0.1356 0.1405
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0043 0.0136 0.004
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.014 0.014
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0384 0.041
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0384 0.1072
Schistosoma mansoni glucose transport protein 0.0307 0.1642 0.1785
Schistosoma mansoni ap endonuclease 0.0037 0.0099 0.0108
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0049 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0044 0.014 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Leishmania major importin beta-1 subunit, putative 0.0023 0.0018 0.0013
Plasmodium falciparum calcium-dependent protein kinase 3 0.0095 0.0432 0.0462
Plasmodium falciparum dihydroorotate dehydrogenase 0.1633 0.9199 1
Trichomonas vaginalis glutaminase, putative 0.0279 0.1478 0.4182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0085 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.015 0.0742 0.0738
Loa Loa (eye worm) hypothetical protein 0.0177 0.0896 0.2547
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0085 0.0092
Brugia malayi hypothetical protein 0.0043 0.0136 0.0148
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1633 0.9199 1
Mycobacterium leprae conserved hypothetical protein 0.0257 0.1356 0.1342
Leishmania major glucose transporter/membrane transporter D2, putative 0.0095 0.0433 0.0464
Onchocerca volvulus 0.0054 0.0195 0.1044
Loa Loa (eye worm) hypothetical protein 0.0112 0.0527 0.1498
Brugia malayi polk-prov protein 0.0066 0.0264 0.0287
Mycobacterium ulcerans acetyl-CoA synthetase 0.0044 0.014 0.0071
Leishmania major lysyl-tRNA synthetase, putative 0.0069 0.0281 0.0298
Giardia lamblia Lysyl-tRNA synthetase 0.0069 0.0281 0.5657
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0112 0.0527 0.0495
Loa Loa (eye worm) sugar transporter 0.0043 0.0136 0.0387
Brugia malayi MH1 domain containing protein 0.0043 0.0137 0.0149
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0192 0.0192
Treponema pallidum bacterioferrin (TpF1) 0.0045 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0742 0.2111
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0264 0.028
Entamoeba histolytica hypothetical protein 0.0035 0.0089 0.0233
Loa Loa (eye worm) nuclear factor I 0.0024 0.0026 0.0075
Brugia malayi N-terminal motif family protein 0.0177 0.0896 0.0974
Echinococcus multilocularis lysyl tRNA synthetase 0.0069 0.0281 0.0281
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Mycobacterium ulcerans sugar transporter 0.0043 0.0136 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0431 0.0469
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0638 0.3525 0.3525
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0155 0.0169
Brugia malayi beta-lactamase family protein 0.0257 0.1356 0.1474
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0143 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0331 0.1777 0.1932
Echinococcus multilocularis expressed protein 0.0038 0.0108 0.0108
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0638 0.3525 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Loa Loa (eye worm) Smad1 0.0043 0.0137 0.0389
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0099 0.0263
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0281 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trypanosoma brucei sugar transporter, putative 0.0043 0.0136 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0384 0.041
Schistosoma mansoni ferritin 0.0045 0.0144 0.0157
Trypanosoma cruzi hexose transporter, putative 0.0095 0.0433 0.0464
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0114 0.0114
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0049 0.0046
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Plasmodium vivax hypothetical protein, conserved 0.0257 0.1356 0.1468
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trypanosoma cruzi hexose transporter 0.0095 0.0433 0.0464
Onchocerca volvulus 0.0043 0.0136 0.0729
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0058 0.0222 0.0172
Loa Loa (eye worm) sugar transporter 0.0307 0.1642 0.4669
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.0048
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.014 0.0083
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.015 0.0742 0.0731
Leishmania major dihydroorotate dehydrogenase 0.1633 0.9199 1
Onchocerca volvulus 0.0043 0.0136 0.0729
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0108 0.0502 0.0539
Brugia malayi hypothetical protein 0.0347 0.1865 0.2027
Loa Loa (eye worm) hypothetical protein 0.0075 0.0317 0.09
Trypanosoma cruzi hexose transporter, putative 0.0095 0.0433 0.0464
Schistosoma mansoni smad 0.0043 0.0137 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0099 0.0101
Toxoplasma gondii facilitative glucose transporter GT1 0.0307 0.1642 0.1779
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0053 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0089 0.009
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.014 0.0083
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0491 0.0527
Echinococcus multilocularis dna polymerase eta 0.0031 0.0064 0.0064
Onchocerca volvulus 0.0043 0.0136 0.0729
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.015 0.0742 0.0665
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0092 0.0415 0.1162
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1633 0.9199 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0043 0.0136 0.0148
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.098 0.098
Giardia lamblia Prolyl-tRNA synthetase 0.0092 0.0415 0.8435
Schistosoma mansoni ferritin 0.0045 0.0144 0.0157
Trypanosoma brucei protein kinase, putative 0.0106 0.0491 0.0527
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0281 0.0225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0492 0.0466
Loa Loa (eye worm) hypothetical protein 0.0044 0.014 0.0398
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0257 0.1356 0.1405
Schistosoma mansoni apoferritin-2 0.0045 0.0144 0.0157
Echinococcus granulosus solute carrier family 22 0.0043 0.0136 0.0136
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0085 0.0085
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0034 0.0037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.014 0.0071
Schistosoma mansoni Smad4 0.0043 0.0137 0.0149
Brugia malayi lysyl-tRNA synthetase 0.0069 0.0281 0.0305
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0034 0.0097
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0257 0.1356 0.3855
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0044 0.014 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0368
Loa Loa (eye worm) hypothetical protein 0.0054 0.0195 0.0553
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0044 0.014 0.0071
Echinococcus multilocularis tumor protein p63 0.1774 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0051 0.0048
Entamoeba histolytica acyl-coA synthetase, putative 0.015 0.0742 0.2091
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.1633 0.9199 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0155 0.0833
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.0491 0.0527
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0671 0.3716 0.4035
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0043 0.0136 0.0079
Plasmodium vivax acyl-CoA synthetase, putative 0.0112 0.0527 0.0566
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Leishmania major 4-coumarate:coa ligase-like protein 0.015 0.0742 0.08
Brugia malayi AMP-binding enzyme family protein 0.0044 0.014 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0492 0.0466
Schistosoma mansoni smad1 5 8 and 0.0043 0.0137 0.0149
Schistosoma mansoni hypothetical protein 0.0328 0.1759 0.1912
Loa Loa (eye worm) hypothetical protein 0.0257 0.1356 0.3855
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0669 0.1902
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.006 0.0232 0.0642
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0669 0.0727
Schistosoma mansoni sugar transporter 0.0043 0.0136 0.0148
Onchocerca volvulus 0.015 0.0742 0.398
Mycobacterium ulcerans hypothetical protein 0.0354 0.1905 0.2005
Schistosoma mansoni ran 0.0021 0.0007 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0099 0.0101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0195 0.0553
Echinococcus granulosus ferritin 0.0045 0.0144 0.0144
Onchocerca volvulus 0.0257 0.1356 0.727
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0092 0.0415 0.0451
Brugia malayi MAP kinase sur-1 0.0106 0.0491 0.0534
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0103 0.0105
Plasmodium vivax proline--tRNA ligase, putative 0.0108 0.0502 0.0539
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0069 0.0281 0.0298
Brugia malayi AMP-binding enzyme family protein 0.015 0.0742 0.0807
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.015 0.0742 0.08
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0095 0.0432 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0155 0.0169
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0155 0.0155
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0034 0.0097
Brugia malayi Smad1 0.0043 0.0137 0.0149
Echinococcus multilocularis expressed protein 0.0045 0.0144 0.0144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0089 0.0089
Echinococcus granulosus Smad4 0.0043 0.0137 0.0137
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0099 0.0108
Toxoplasma gondii hypothetical protein 0.0108 0.0507 0.0544
Schistosoma mansoni hypothetical protein 0.0291 0.1548 0.1683
Schistosoma mansoni z-protein (S1r protein) 0.0027 0.0045 0.0049
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0053 0.0151
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0095 0.0432 0.0462
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0043 0.0136 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0742 0.0731
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0128
Schistosoma mansoni glucose transport protein 0.0307 0.1642 0.1785
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0331 0.1777 0.1932
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0058 0.0222 0.0172
Onchocerca volvulus 0.0043 0.0136 0.0729
Brugia malayi MH2 domain containing protein 0.0043 0.0137 0.0149
Schistosoma mansoni glutaminase 0.0279 0.1478 0.1607
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0195 0.0553
Echinococcus multilocularis musashi 0.0054 0.0195 0.0195
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1633 0.9199 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0257 0.1356 0.1474
Echinococcus granulosus lamin dm0 0.0054 0.0195 0.0195
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0038 0.0105 0.03
Trypanosoma cruzi hexose transporter, putative 0.0095 0.0433 0.0464
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0192 0.0209
Echinococcus multilocularis smad 0.0043 0.0137 0.0137
Loa Loa (eye worm) beta-lactamase 0.0257 0.1356 0.3855
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.0491 0.0491
Echinococcus multilocularis solute carrier family 22 0.0043 0.0136 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0257 0.1356 0.1405
Schistosoma mansoni hypothetical protein 0.0328 0.1759 0.1912
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.1633 0.9199 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0099 0.0101
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0112 0.0527 0.0504
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0089
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.014 0.0379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0384 0.041
Brugia malayi mbt repeat family protein 0.0047 0.0155 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Schistosoma mansoni dihydroorotate dehydrogenase 0.1633 0.9199 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5471 0.5471
Echinococcus multilocularis geminin 0.0328 0.1759 0.1759
Loa Loa (eye worm) transcription factor SMAD2 0.0636 0.3517 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0428 0.0458
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0092 0.0415 0.0451
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.014 0.0398
Onchocerca volvulus 0.0044 0.014 0.075
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0742 0.0731
Schistosoma mansoni ferritin 0.0045 0.0144 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Plasmodium falciparum calcium-dependent protein kinase 4 0.0095 0.0432 0.0462
Toxoplasma gondii lysine-tRNA ligase 0.0069 0.0281 0.0298
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0638 0.3525 0.3827
Echinococcus multilocularis solute carrier family 22 0.0043 0.0136 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0044 0.014 0.0152
Brugia malayi Cam kinase protein 1 0.0095 0.0431 0.0469
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0103 0.0273
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.0491 0.0527
Echinococcus granulosus intermediate filament protein 0.0054 0.0195 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0095 0.0433 0.1212
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0043 0.0136 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0304 0.0324
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0031 0.0064 0.0064
Plasmodium vivax importin-beta 2, putative 0.0028 0.0049 0.0046
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.1633 0.9199 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0069 0.0281 0.0155
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Loa Loa (eye worm) MBCTL1 0.0053 0.0192 0.0547
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0223 0.0633
Schistosoma mansoni hypothetical protein 0.005 0.0172 0.0187
Echinococcus multilocularis snurportin 1 0.0298 0.1587 0.1587
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0051 0.0051
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0502 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0095 0.0432 0.0462
Brugia malayi AMP-binding enzyme family protein 0.0044 0.014 0.0152
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.015 0.0742 0.0731
Loa Loa (eye worm) glutaminase 0.0279 0.1478 0.4202
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.1642 0.4649
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0043 0.0136 0.0141
Brugia malayi MH1 domain containing protein 0.0024 0.0026 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.1356 0.1468
Loa Loa (eye worm) major facilitator superfamily transporter 0.0043 0.0136 0.0387
Schistosoma mansoni sugar transporter 0.0043 0.0136 0.0148
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Echinococcus multilocularis General substrate transporter 0.0264 0.1396 0.1396
Onchocerca volvulus 0.0043 0.0136 0.0729
Trypanosoma brucei THT1 - hexose transporter, putative 0.0095 0.0433 0.0464
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0018 0.0034
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0172 0.0187
Entamoeba histolytica acyl-CoA synthetase, putative 0.015 0.0742 0.2091
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0095 0.0431 0.0431
Mycobacterium ulcerans esterase/lipase LipP 0.0257 0.1356 0.1404
Onchocerca volvulus 0.0043 0.0136 0.0729
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0089 0.0089
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0257 0.1356 0.1405
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0384 0.1072
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0264 0.028
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0058 0.0222 0.009
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Plasmodium falciparum protein kinase 6 0.1306 0.7332 0.797
Loa Loa (eye worm) hypothetical protein 0.004 0.0115 0.0328
Leishmania major glucose transporter, lmgt3 0.0095 0.0433 0.0464
Plasmodium falciparum protein kinase 7 0.087 0.4846 0.5265
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0498 0.2726 0.2959
Leishmania major myo-inositol/proton symporter (MIT) 0.0043 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.015 0.0742 0.0731
Schistosoma mansoni tar DNA-binding protein 0.0331 0.1777 0.1932
Leishmania major DNA polymerase eta, putative 0.0031 0.0064 0.0062
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0428 0.0458
Mycobacterium ulcerans lipase LipD 0.0257 0.1356 0.1404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0108 0.0502 0.0539
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0064 0.0069
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.014 0.0145
Trichomonas vaginalis penicillin-binding protein, putative 0.0257 0.1356 0.3835
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0257 0.1356 0.1474
Mycobacterium leprae Probable lipase LipE 0.0257 0.1356 0.1342
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0433 0.1212
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0044 0.014 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0431 0.1207
Trichomonas vaginalis sugar transport protein, putative 0.0043 0.0136 0.0368
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Brugia malayi Bromodomain containing protein 0.0028 0.0051 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Toxoplasma gondii transporter, major facilitator family protein 0.0043 0.0136 0.0141
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0187 0.0196
Loa Loa (eye worm) oxidoreductase 0.0044 0.014 0.0398
Loa Loa (eye worm) hypothetical protein 0.0095 0.0431 0.1226
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0108 0.0502 0.0539
Trichomonas vaginalis sugar transporter, putative 0.0095 0.0433 0.1212
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.014 0.0083
Echinococcus multilocularis Smad4 0.0043 0.0137 0.0137
Plasmodium falciparum calcium-dependent protein kinase 1 0.0095 0.0432 0.0462
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0491 0.0534
Chlamydia trachomatis lysine--tRNA ligase 0.0069 0.0281 0.4551
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Trypanosoma brucei THT1 - hexose transporter, putative 0.0095 0.0433 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0145
Loa Loa (eye worm) RNA binding protein 0.0331 0.1777 0.5054
Loa Loa (eye worm) hypothetical protein 0.0112 0.0527 0.1498
Onchocerca volvulus 0.0043 0.0136 0.0729
Plasmodium falciparum acyl-CoA synthetase 0.0112 0.0527 0.0566
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0257 0.1356 0.1405
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0095 0.0431 0.0469
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0044 0.014 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0099 0.0263
Brugia malayi Sugar transporter family protein 0.0043 0.0136 0.0148
Schistosoma mansoni intermediate filament proteins 0.0054 0.0195 0.0212
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0045 0.0144 0.0088
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0099 0.3476
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.0491 0.0527
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Schistosoma mansoni hypothetical protein 0.0035 0.0089 0.0096
Trypanosoma cruzi glucose transporter, putative 0.0043 0.0136 0.0141
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0043 0.0136 0.0141
Entamoeba histolytica deoxycytidyl transferase, putative 0.0031 0.0064 0.0162
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Schistosoma mansoni importin beta-1 0.0028 0.0049 0.0053
Entamoeba histolytica protein kinase, putative 0.0095 0.0431 0.1207
Loa Loa (eye worm) hypothetical protein 0.026 0.1369 0.3894
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0031 0.0064 0.0064
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.014 0.0145
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0155 0.0169
Loa Loa (eye worm) hypothetical protein 0.015 0.0742 0.2111
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0491 0.1377
Onchocerca volvulus 0.0257 0.1356 0.727
Loa Loa (eye worm) hypothetical protein 0.0257 0.1356 0.3855
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0043 0.0136 0.0136
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.014 0.0083
Schistosoma mansoni lamin 0.0054 0.0195 0.0212
Schistosoma mansoni glucose transporter 0.0043 0.0136 0.0148
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.0049 0.0166 0.0473
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0099 0.0099
Schistosoma mansoni ferritin light chain 0.0045 0.0144 0.0157
Onchocerca volvulus 0.0043 0.0136 0.0729
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0192 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0384 0.041
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0018 0.0013
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0498 0.2726 0.2959
Trichomonas vaginalis esterase, putative 0.0257 0.1356 0.3835
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0036 0.0032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0031 0.0064 0.0069
Onchocerca volvulus 0.026 0.1369 0.7343
Echinococcus multilocularis lamin dm0 0.0054 0.0195 0.0195
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0155 0.0155
Echinococcus multilocularis calcium dependent protein kinase 0.0088 0.0393 0.0393
Leishmania major hypothetical protein, conserved 0.0043 0.0136 0.0141
Onchocerca volvulus 0.0047 0.0155 0.0833
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.1356 0.3835
Brugia malayi beta-lactamase 0.0257 0.1356 0.1474
Mycobacterium ulcerans glutaminase 0.0279 0.1478 0.1537
Toxoplasma gondii sugar transporter ST1 0.0043 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.0053 0.0189 0.0537
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0137 0.0137
Onchocerca volvulus 0.0054 0.0195 0.1044
Mycobacterium tuberculosis Probable esterase LipL 0.0257 0.1356 0.1405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0257 0.1356 0.1474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0018 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0099 0.0263
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.014 0.0083
Brugia malayi Sugar transporter family protein 0.0043 0.0136 0.0148
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0092 0.0415 0.0304
Brugia malayi hypothetical protein 0.0035 0.0089 0.0096
Plasmodium vivax sugar transporter, putative 0.0043 0.0136 0.0141
Trichomonas vaginalis glucose transporter, putative 0.0043 0.0136 0.0368
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.014 0.0083
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0103 0.0105
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0051 0.0055
Brugia malayi RNA, U transporter 1 0.0079 0.0342 0.0372
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0108 0.0117
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0085 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.015 0.0742 0.2091
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0137 0.0389
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.014 0.0152
Toxoplasma gondii exonuclease III APE 0.0037 0.0099 0.0101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0638 0.3525 1
Brugia malayi Major Facilitator Superfamily protein 0.0043 0.0136 0.0148
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0137 0.0137
Echinococcus multilocularis ferritin 0.0045 0.0144 0.0144
Mycobacterium ulcerans bacterioferritin BfrA 0.0045 0.0144 0.0076
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0099 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0669 0.0669
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.1633 0.9199 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0037 0.0037
Echinococcus granulosus expressed protein 0.0038 0.0108 0.0108
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0638 0.3525 0.3525
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0318 0.17 0.1843
Brugia malayi Importin beta-1 subunit 0.0028 0.0049 0.0053
Brugia malayi PHD-finger family protein 0.0028 0.0051 0.0055
Schistosoma mansoni smad1 5 8 and 0.0043 0.0137 0.0149
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Leishmania major hypothetical protein, conserved 0.0257 0.1356 0.1468
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0092 0.0415 0.1162
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.014 0.0083
Schistosoma mansoni ran 0.0021 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0671 0.3716 0.4035
Brugia malayi Major Facilitator Superfamily protein 0.0043 0.0136 0.0148
Mycobacterium ulcerans hypothetical protein 0.015 0.0742 0.0731
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.014 0.0398
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1276 0.1276
Schistosoma mansoni smad1 5 8 and 0.0043 0.0137 0.0149
Entamoeba histolytica hypothetical protein 0.0035 0.0089 0.0233
Brugia malayi MH1 domain containing protein 0.0043 0.0137 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0368
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0155 0.0155
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0257 0.1356 0.3855
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0007 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.1356 0.1468
Toxoplasma gondii protein kinase, putative 0.087 0.4846 0.5265
Trypanosoma brucei DNA polymerase eta, putative 0.0031 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0058 0.022 0.0625
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0491 0.1377
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0105
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0502 0.0539
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0032
Onchocerca volvulus 0.0043 0.0136 0.0729
Leishmania major hypothetical protein, conserved 0.0026 0.0036 0.0032
Plasmodium falciparum phd finger protein, putative 0.0028 0.0051 0.0048
Schistosoma mansoni hypothetical protein 0.0298 0.1587 0.1726
Brugia malayi intermediate filament protein 0.0054 0.0195 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0064 0.0069
Onchocerca volvulus Putative transporter 0.0043 0.0136 0.0729
Echinococcus granulosus peregrin 0.0028 0.0051 0.0051
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0095 0.0431 0.1226
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0051 0.0145
Plasmodium vivax lysine--tRNA ligase, putative 0.0069 0.0281 0.0298
Brugia malayi MH1 domain containing protein 0.0024 0.0026 0.0028
Brugia malayi beta-lactamase family protein 0.0257 0.1356 0.1474
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0384 0.041
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0638 0.3525 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0044 0.014 0.0071
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.014 0.0145
Trypanosoma brucei glucose transporter 1E 0.0095 0.0433 0.0464
Brugia malayi jmjC domain containing protein 0.0034 0.0085 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.1356 0.3835
Plasmodium vivax CDK-related protein kinase 6, putative 0.1306 0.7332 0.797
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0095 0.0432 0.0462
Loa Loa (eye worm) hypothetical protein 0.0257 0.1356 0.3855
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0384 0.0338
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0492 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trichomonas vaginalis myo-inositol transporter, putative 0.0043 0.0136 0.0368
Toxoplasma gondii propionate-CoA ligase 0.0044 0.014 0.0145
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Echinococcus multilocularis solute carrier family 22 0.0043 0.0136 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Brugia malayi MH2 domain containing protein 0.0636 0.3517 0.3823
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Brugia malayi regulator of G-protein signaling egl-10 0.0027 0.0045 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1587 0.4514
Loa Loa (eye worm) hypothetical protein 0.0053 0.0192 0.0547
Trichomonas vaginalis sugar transporter, putative 0.0095 0.0433 0.1212
Trypanosoma cruzi hexose transporter, putative 0.0043 0.0136 0.0141
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.022 0.0625
Loa Loa (eye worm) TAR-binding protein 0.0331 0.1777 0.5054
Echinococcus multilocularis regulator of G protein signaling 7 0.0027 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.015 0.0742 0.2111
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0095 0.0431 0.1226
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0094 0.0428 0.0458
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0092 0.0415 0.0451
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0099 0.0282
Brugia malayi hypothetical protein 0.0243 0.1276 0.1387
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0112 0.0527 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0192 0.0192
Schistosoma mansoni terminal deoxycytidyl transferase 0.0031 0.0064 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Entamoeba histolytica hypothetical protein 0.0069 0.0281 0.0779
Plasmodium falciparum lysine--tRNA ligase 0.0069 0.0281 0.0298
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0099 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0492 0.0466
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1633 0.9199 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Plasmodium falciparum proline--tRNA ligase 0.0108 0.0502 0.0539
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0095 0.0431 0.0462
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0099 0.0026
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0137 0.0137
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0115 0.0125
Loa Loa (eye worm) hypothetical protein 0.0066 0.0264 0.0749
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.1633 0.9199 0.9936
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0044 0.014 0.0071
Trypanosoma brucei unspecified product 0.0021 0.001 0.0003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0031 0.0064 0.0181
Schistosoma mansoni cellular tumor antigen P53 0.026 0.1369 0.1489
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0181
Onchocerca volvulus 0.0043 0.0136 0.0729
Echinococcus multilocularis solute carrier family 22 0.0043 0.0136 0.0136
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.014 0.0145
Echinococcus multilocularis lamin 0.0054 0.0195 0.0195
Echinococcus granulosus Sugar transporter ERD6 protein 0.0043 0.0136 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0034 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0491 0.1377
Loa Loa (eye worm) hypothetical protein 0.0112 0.0527 0.1498
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0638 0.3525 0.3525
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.014 0.0083
Giardia lamblia Hexose transporter 0.0043 0.0136 0.267
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.0491 0.0491
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0099 0.1911
Schistosoma mansoni tar DNA-binding protein 0.0331 0.1777 0.1932
Echinococcus granulosus lamin 0.0054 0.0195 0.0195
Schistosoma mansoni sugar transporter 0.0043 0.0136 0.0148
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Loa Loa (eye worm) hypothetical protein 0.0257 0.1356 0.3855
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0307 0.1642 0.1642
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0137 0.0389
Schistosoma mansoni lamin 0.0054 0.0195 0.0212
Entamoeba histolytica protein kinase, putative 0.0095 0.0431 0.1207
Schistosoma mansoni survival motor neuron protein 0.005 0.0172 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0669 0.0727
Onchocerca volvulus 0.0043 0.0136 0.0729
Loa Loa (eye worm) hypothetical protein 0.0257 0.1356 0.3855
Mycobacterium ulcerans bacterioferritin BfrB 0.0045 0.0144 0.0076
Brugia malayi mbt repeat family protein 0.0047 0.0155 0.0169
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Brugia malayi RNA recognition motif domain containing protein 0.0331 0.1777 0.1932
Onchocerca volvulus 0.0043 0.0136 0.0729
Entamoeba histolytica hypothetical protein 0.0035 0.0089 0.0233
Schistosoma mansoni protein kinase 0.0095 0.0431 0.0469
Plasmodium vivax calcium-dependent protein kinase, putative 0.0095 0.0432 0.0462
Schistosoma mansoni sugar transporter 0.0043 0.0136 0.0148
Echinococcus granulosus regulator of G protein signaling 7 0.0027 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0347 0.1865 0.5303
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0036 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0281 0.0305
Trypanosoma brucei unspecified product 0.0073 0.0304 0.0324
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.014 0.0145
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0669 0.0669
Onchocerca volvulus 0.0257 0.1356 0.727
Leishmania major glucose transporter, lmgt1 0.0095 0.0433 0.0464
Onchocerca volvulus 0.0043 0.0136 0.0729
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0638 0.3525 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0669 0.0727
Echinococcus granulosus snurportin 1 0.0298 0.1587 0.1587
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0049 0.0046
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0045 0.0144 0.0005
Trichomonas vaginalis glucose transporter, putative 0.0095 0.0433 0.1212
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0638 0.3525 1
Toxoplasma gondii ABC1 family protein 0.0257 0.1356 0.1468
Schistosoma mansoni DNA polymerase eta 0.0031 0.0064 0.0069
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0007 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Brugia malayi Major Facilitator Superfamily protein 0.0043 0.0136 0.0148
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Onchocerca volvulus 0.0044 0.014 0.075
Brugia malayi hypothetical protein 0.0043 0.0136 0.0148
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0192 0.0192
Loa Loa (eye worm) major facilitator superfamily transporter 0.0043 0.0136 0.0387
Echinococcus multilocularis beta LACTamase domain containing family member 0.0257 0.1356 0.1356
Plasmodium vivax hexose transporter 0.0307 0.1642 0.1779
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0045 0.0144 0.0049
Onchocerca volvulus Alhambra homolog 0.0028 0.0051 0.0273
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1276 0.1276
Onchocerca volvulus 0.0043 0.0136 0.0729
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0103 0.0105
Leishmania major DNA polymerase kappa, putative 0.0044 0.0143 0.0149
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.014 0.0152
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0155 0.0442
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0023 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0491 0.1377
Echinococcus granulosus geminin 0.0328 0.1759 0.1759
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0669 0.0669
Onchocerca volvulus 0.0044 0.014 0.075
Trichomonas vaginalis penicillin-binding protein, putative 0.0257 0.1356 0.3835
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.014 0.014
Plasmodium falciparum hexose transporter 0.0307 0.1642 0.1779
Giardia lamblia DINP protein human, muc B family 0.0044 0.0143 0.2817
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0502 0.0539
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0243 0.1276 0.3628
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0099 0.0099
Brugia malayi Sugar transporter family protein 0.0307 0.1642 0.1785
Trichomonas vaginalis ferritin, putative 0.0045 0.0144 0.0391
Onchocerca volvulus 0.005 0.0172 0.0924
Echinococcus multilocularis synaptic vesicle 2 protein 0.0043 0.0136 0.0136
Echinococcus multilocularis regulator of G protein signaling 7 0.0027 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0112 0.0527 0.1498
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0384 0.0338
Echinococcus granulosus expressed protein 0.0362 0.1956 0.1956
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0089 0.009
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.1633 0.9199 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1644 0.9257 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.014 0.0152
Echinococcus multilocularis expressed protein 0.0362 0.1956 0.1956
Echinococcus granulosus tar DNA binding protein 0.0331 0.1777 0.1777
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0309 0.0336
Trichomonas vaginalis glucose transporter, putative 0.0095 0.0433 0.1212
Trichomonas vaginalis rotamase, putative 0.0037 0.0103 0.0273
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0638 0.3525 1
Echinococcus granulosus dna polymerase eta 0.0031 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0669 0.0669
Schistosoma mansoni protein kinase 0.0095 0.0431 0.0469
Brugia malayi hypothetical protein 0.0043 0.0136 0.0148
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.014 0.0083
Loa Loa (eye worm) hypothetical protein 0.0092 0.0415 0.1181
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0018 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.1356 0.3835
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0137 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Schistosoma mansoni rotamase 0.0038 0.0108 0.0117
Giardia lamblia Sugar-proton symporter 0.0043 0.0136 0.267
Brugia malayi TAR-binding protein 0.0331 0.1777 0.1932
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0257 0.1356 0.1404
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.014 0.0379
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0085 0.0241
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0671 0.3716 0.4035
Echinococcus granulosus calcium dependent protein kinase 0.0088 0.0393 0.0393
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0318 0.17 0.1843
Schistosoma mansoni glucose transport protein 0.0307 0.1642 0.1785
Mycobacterium ulcerans integral membrane transport protein 0.0043 0.0136 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0384 0.041
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0638 0.3525 0.3525
Schistosoma mansoni apoferritin-2 0.0045 0.0144 0.0157
Mycobacterium tuberculosis Conserved protein 0.0257 0.1356 0.1405
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0069 0.0281 0.0298
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0491 0.0527
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0043 0.0136 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Mycobacterium ulcerans beta-lactamase 0.0257 0.1356 0.1404
Brugia malayi Zinc finger, C2H2 type family protein 0.0638 0.3525 0.3832
Echinococcus multilocularis tar DNA binding protein 0.0331 0.1777 0.1777
Brugia malayi jmjC domain containing protein 0.0093 0.0418 0.0454
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0045 0.0144 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.022 0.0239
Loa Loa (eye worm) glutaminase 2 0.0279 0.1478 0.4202
Entamoeba histolytica hypothetical protein 0.0035 0.0089 0.0233
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0034 0.0034
Echinococcus granulosus smad 0.0043 0.0137 0.0137
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0037 0.0037
Brugia malayi glutaminase DH11.1 0.0279 0.1478 0.1607
Trypanosoma cruzi sugar transporter, putative 0.0043 0.0136 0.0141
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0105 0.0045
Plasmodium falciparum mitogen-activated protein kinase 2 0.0498 0.2726 0.2959
Echinococcus granulosus solute carrier family 22 0.0043 0.0136 0.0136
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.1633 0.9199 1
Echinococcus granulosus lysyl tRNA synthetase 0.0069 0.0281 0.0281
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0137 0.0149
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0798
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.014 0.0145
Onchocerca volvulus 0.0044 0.014 0.075
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0103 0.0105
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0114 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Plasmodium falciparum calcium-dependent protein kinase 2 0.0095 0.0432 0.0462
Giardia lamblia PHD finger protein 15 0.0028 0.0051 0.0915
Echinococcus granulosus solute carrier family 22 0.0043 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0028 0.0051 0.0055
Echinococcus granulosus solute carrier family 22 0.0043 0.0136 0.0136
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.015 0.0742 0.0731
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0155 0.0155
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.0491 0.0527
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0034 0.0037
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0092 0.0415 0.0451
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0431 0.0431
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0092 0.0415 0.1181
Mycobacterium tuberculosis Conserved protein 0.0257 0.1356 0.1405
Mycobacterium tuberculosis Conserved hypothetical protein 0.0354 0.1905 0.2003
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.098 0.098
Leishmania major mitochondrial DNA polymerase beta 0.0671 0.3716 0.4035
Toxoplasma gondii sugar transporter ST2 0.0043 0.0136 0.0141
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0281 0.0305
Onchocerca volvulus 0.0347 0.1865 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0027 0.0045 0.0128
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0044 0.014 0.0071
Entamoeba histolytica hypothetical protein 0.0023 0.0018 0.0034
Plasmodium falciparum calcium-dependent protein kinase 5 0.0095 0.0432 0.0462
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.015 0.0742 0.0738
Brugia malayi AMP-binding enzyme family protein 0.015 0.0742 0.0807
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0384 0.041
Schistosoma mansoni hypothetical protein 0.0307 0.1642 0.1785
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.0491 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0143 0.0149
Brugia malayi major facilitator superfamily protein 0.0043 0.0136 0.0148
Toxoplasma gondii sugar transporter ST3 0.0043 0.0136 0.0141
Leishmania major protein kinase, putative 0.0095 0.0431 0.0462
Leishmania major 4-coumarate:coa ligase-like protein 0.015 0.0742 0.08
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0103 0.0105
Brugia malayi RNA binding protein 0.0331 0.1777 0.1932
Trypanosoma brucei THT1 - hexose transporter, putative 0.0095 0.0433 0.0464
Echinococcus multilocularis peregrin 0.0028 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0108 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0742 0.0731
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0331 0.1777 0.5054
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.0491 0.1396
Schistosoma mansoni ferritin 0.0045 0.0144 0.0157
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Schistosoma mansoni protein kinase 0.0095 0.0431 0.0469
Echinococcus granulosus importin subunit beta 1 0.0028 0.0049 0.0049
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.014 0.0083
Trypanosoma brucei unspecified product 0.0021 0.001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0368
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0638 0.3525 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0418 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.1356 0.1468
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0143 0.0149
Echinococcus granulosus beta LACTamase domain containing family member 0.0257 0.1356 0.1356
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0384 0.0384
Schistosoma mansoni ap endonuclease 0.0037 0.0099 0.0108
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0051 0.0048
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0051 0.0051
Mycobacterium tuberculosis Probable lipase LipD 0.0257 0.1356 0.1405
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0318 0.17 0.1843
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Echinococcus granulosus dna polymerase kappa 0.0087 0.0384 0.0384
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0669 0.0727
Loa Loa (eye worm) MH2 domain-containing protein 0.0636 0.3517 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.0491 0.0527
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.0896 0.4804
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0099 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0034 0.0037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1642 0.1642
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1633 0.9199 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0195 0.0212
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0095 0.0432 0.0462
Plasmodium falciparum importin beta, putative 0.0028 0.0049 0.0046
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.014 0.0083
Loa Loa (eye worm) hypothetical protein 0.0112 0.0527 0.1498
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.014 0.0071
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.0491 0.0527
Onchocerca volvulus 0.0043 0.0136 0.0729
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.0545 0.0586
Echinococcus granulosus General substrate transporter 0.0264 0.1396 0.1396
Trypanosoma brucei glucose transporter 2A 0.0095 0.0433 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0331 0.1777 0.1932
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0433 0.1212
Mycobacterium tuberculosis Probable hydrolase 0.0257 0.1356 0.1405
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0092 0.0415 0.0415
Trypanosoma brucei glucose transporter, putative 0.0095 0.0433 0.0464
Brugia malayi AMP-binding enzyme family protein 0.015 0.0742 0.0807
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0092 0.0415 0.0415
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0368
Loa Loa (eye worm) hypothetical protein 0.0047 0.0155 0.0442
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0094 0.0428 0.0458
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0075
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0095 0.0432 0.0462
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0089 0.0096
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.0491 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0089 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0138
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0387
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0069 0.0281 0.0779
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0136 0.0368
Onchocerca volvulus 0.0043 0.0136 0.0729
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.015 0.0742 0.0665
Echinococcus granulosus regulator of G protein signaling 7 0.0027 0.0045 0.0045
Mycobacterium ulcerans hypothetical protein 0.0257 0.1356 0.1404
Echinococcus granulosus expressed protein 0.0045 0.0144 0.0144
Leishmania major glucose transporter, lmgt2 0.0095 0.0433 0.0464
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0045 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0368
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.014 0.0145
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0192 0.0209

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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