Detailed information for compound 802635

Basic information

Technical information
  • TDR Targets ID: 802635
  • Name: 3-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonylam ino]-N-[4-(trifluoromethoxy)phenyl]propanamid e
  • MW: 471.45 | Formula: C20H20F3N3O5S
  • H donors: 2 H acceptors: 4 LogP: 2.27 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)OC(F)(F)F)CCNS(=O)(=O)c1ccc2c(c1)CCN2C(=O)C
  • InChi: 1S/C20H20F3N3O5S/c1-13(27)26-11-9-14-12-17(6-7-18(14)26)32(29,30)24-10-8-19(28)25-15-2-4-16(5-3-15)31-20(21,22)23/h2-7,12,24H,8-11H2,1H3,(H,25,28)
  • InChiKey: IUEPSZCNAMARAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1-acetylindolin-5-yl)sulfonylamino]-N-[4-(trifluoromethoxy)phenyl]propanamide
  • 3-[(1-acetyl-5-indolinyl)sulfonylamino]-N-[4-(trifluoromethoxy)phenyl]propanamide
  • 3-[(1-acetylindolin-5-yl)sulfonylamino]-N-[4-(trifluoromethoxy)phenyl]propionamide
  • 3-[(1-ethanoyl-2,3-dihydroindol-5-yl)sulfonylamino]-N-[4-(trifluoromethoxy)phenyl]propanamide
  • EU-0059972

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0115 0.0391 0.0789
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0114 0.0113
Echinococcus multilocularis RUN 0.0041 0.0087 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0347 0.1909
Echinococcus granulosus acetylcholinesterase 0.0069 0.0201 0.0404
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.007 0.0206 0.1195
Leishmania major hypothetical protein, conserved 0.0022 0.0009 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0114 0.0351
Schistosoma mansoni pyruvate kinase 0.0033 0.0056 0.0113
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0323 0.0322
Giardia lamblia Kinase, PLK 0.0096 0.0311 0.8955
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 1
Schistosoma mansoni smad 0.0024 0.0019 0.0036
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0347 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0311 0.1044
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0114 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0418 0.1629 0.1629
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0056 0.0498
Echinococcus granulosus cpg binding protein 0.0092 0.0294 0.0591
Loa Loa (eye worm) hypothetical protein 0.007 0.0206 0.0416
Trichomonas vaginalis ran, putative 0.0064 0.0182 0.1
Trypanosoma brucei hypothetical protein, conserved 0.0292 0.1112 0.9902
Onchocerca volvulus 0.0027 0.0031 0.0009
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0015 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0125 0.3026
Schistosoma mansoni lamin 0.0027 0.0031 0.0061
Echinococcus multilocularis translational activator gcn1 0.0022 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0087 0.0175
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.003 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0061 0.017 0.0341
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.004 0.0039
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0087 0.0174
Schistosoma mansoni nuclear receptor 0.0029 0.004 0.0079
Brugia malayi AMP-binding enzyme family protein 0.007 0.0206 0.064
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0031 0.0102
Brugia malayi ecdysone receptor 0.0029 0.004 0.0122
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0142 0.0188
Mycobacterium tuberculosis Probable dehydrogenase 0.0179 0.0652 0.0864
Trypanosoma brucei trypanothione reductase 0.0079 0.0241 0.214
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0031 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0225 0.0452
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0169 0.0525
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0031 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0174 0.0351
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0163 0.0162
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0214 0.1181
Leishmania major acetyl-CoA synthetase, putative 0.007 0.0206 0.0703
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0089 0.0298
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0081 0.1881
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0022 0.0044
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0174 0.0174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0174 0.035
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0163 0.0896
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0155 0.0311
Entamoeba histolytica hypothetical protein 0.0441 0.1723 1
Onchocerca volvulus 0.007 0.0206 0.099
Brugia malayi nuclear hormone receptor 0.0029 0.004 0.0122
Schistosoma mansoni smad1 5 8 and 0.0024 0.0019 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0206 0.0703
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0166 0.0333
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0214 0.072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0225 0.0452
Mycobacterium ulcerans acetyl-CoA synthetase 0.007 0.0206 0.064
Echinococcus granulosus lamin dm0 0.0027 0.0031 0.0061
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0096 0.0526
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.004 0.0122
Echinococcus granulosus tar DNA binding protein 0.0061 0.017 0.0341
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.1123 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.0206 0.064
Schistosoma mansoni polycystin 1-related 0.0041 0.0087 0.0174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.0679 0.1368
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0206 0.0273
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0019 0.0036
Schistosoma mansoni alpha glucosidase 0.0072 0.0214 0.0431
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0038 0.0076
Brugia malayi hypothetical protein 0.0029 0.004 0.0122
Leishmania major fatty acid transporter protein-like protein 0.0737 0.293 1
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.0241 0.2102
Echinococcus granulosus sodium:myo inositol cotransporter 0.0113 0.0383 0.0771
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.007 0.0206 0.0586
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.003 0.0163
Schistosoma mansoni hypothetical protein 0.1178 0.4733 0.954
Onchocerca volvulus 0.0292 0.1112 0.6056
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0347 0.1909
Trypanosoma brucei polo-like protein kinase 0.0096 0.0311 0.2763
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.1049 0.326
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0155 0.1324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0031 0.0061
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0056 0.0068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.017 0.0342
Schistosoma mansoni hypothetical protein 0.0441 0.1723 0.3473
Brugia malayi beta-lactamase family protein 0.0292 0.1112 0.3456
Echinococcus multilocularis pyruvate kinase 0.0033 0.0056 0.0056
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0087 0.0174
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0189 0.069 0.069
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0199 0.0734 0.2409
Onchocerca volvulus 0.0113 0.0383 0.1977
Loa Loa (eye worm) carboxylesterase 0.0069 0.0201 0.0405
Schistosoma mansoni rab6-interacting 0.0041 0.0087 0.0174
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0201 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 1
Schistosoma mansoni ran 0.0064 0.0182 0.0365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0174 0.0174
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0056 0.0311
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0206 0.0273
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.007 0.0206 0.0693
Leishmania major glycosyl hydrolase-like protein 0.0027 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0489 0.4353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.0404 0.1255
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0311 0.1058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0143 0.0503 0.1013
Mycobacterium tuberculosis Probable reductase 0.0179 0.0652 0.0864
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0247 0.0247
Loa Loa (eye worm) acetyltransferase 0.0146 0.0517 0.1043
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0031 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0174 0.0351
Leishmania major pantothenate kinase subunit, putative 0.0022 0.0009 0.0028
Brugia malayi Doublecortin family protein 0.0041 0.0087 0.0269
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0163 0.0896
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.006 0.0167 0.022
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0056 0.0113
Echinococcus multilocularis importin 5 0.0022 0.0009 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0214 0.072
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0517 0.0517
Brugia malayi hypothetical protein 0.0041 0.0087 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0174 0.054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0292 0.1112 0.3456
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0114 0.101
Onchocerca volvulus 0.0087 0.0274 0.1367
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.003 0.0098
Plasmodium vivax acetyl-CoA synthetase, putative 0.007 0.0206 0.179
Onchocerca volvulus 0.0062 0.0174 0.0809
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0179 0.0652 0.0864
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.1049 0.2117
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0114 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.1112 0.3743
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0311 0.031
Leishmania major trypanothione reductase 0.0079 0.0241 0.082
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0174 0.035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0174 0.035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0418 0.1629 0.3289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0174 0.054
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0056 0.0188
Onchocerca volvulus Huntingtin homolog 0.0123 0.0424 0.2205
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0064 0.0182 0.5232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0108
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.1867 0.1866
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0418 0.1629 0.1629
Loa Loa (eye worm) hypothetical protein 0.0292 0.1112 0.2244
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0169 0.1456
Brugia malayi hypothetical protein 0.0086 0.027 0.0837
Mycobacterium tuberculosis Conserved protein 0.0292 0.1112 0.1475
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0206 0.064
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Toxoplasma gondii hypothetical protein 0.0029 0.0037 0.0252
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0114 0.0382
Onchocerca volvulus 0.007 0.0206 0.099
Schistosoma mansoni nuclear hormone receptor 0.0029 0.004 0.0079
Schistosoma mansoni zinc finger protein 0.0029 0.004 0.0079
Echinococcus multilocularis dnaJ subfamily B 0.1234 0.4961 0.4961
Mycobacterium ulcerans hypothetical protein 0.007 0.0206 0.064
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0081 0.2319
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.004 0.0039
Schistosoma mansoni pyruvate kinase 0.0033 0.0056 0.0113
Echinococcus multilocularis solute carrier family 5 0.0113 0.0383 0.0382
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0155 0.1324
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.0404 0.1255
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Onchocerca volvulus Alhambra homolog 0.0058 0.0155 0.0702
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0174 0.0174
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.004 0.0039
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0031 0.0104
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0206 0.0586
Loa Loa (eye worm) hypothetical protein 0.0058 0.0155 0.0312
Trypanosoma brucei glucosidase, putative 0.0072 0.0214 0.1906
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0054 0.0108
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0114 0.0229
Brugia malayi CHE-14 protein 0.0042 0.0093 0.0287
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0143 0.0503 0.0502
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0113 0.0383 0.0382
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0056 0.0151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0087 0.0175
Echinococcus granulosus intermediate filament protein 0.0027 0.0031 0.0061
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0174 0.035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0214 0.1242
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0096 0.0785
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.003 0.0098
Echinococcus granulosus RUN 0.0041 0.0087 0.0174
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0056 0.0188
Plasmodium falciparum glutathione reductase 0.0079 0.0241 0.6063
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0311 0.1044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0166 0.0165
Schistosoma mansoni smad1 5 8 and 0.0024 0.0019 0.0036
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0064 0.0182 0.0563
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0174 0.035
Schistosoma mansoni tar DNA-binding protein 0.0061 0.017 0.0341
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0517 0.1042
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0019 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0163 0.0327
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.0404 0.0404
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.0405 0.0818
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0038 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0125 0.0418
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0166 0.142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0163 0.0215
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0115 0.0231
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0259 0.227
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0746 0.2969 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0174 0.0809
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0174 0.0174
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0056 0.0113
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0064 0.0182 0.1566
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Brugia malayi AMP-binding enzyme family protein 0.007 0.0206 0.064
Brugia malayi Probable ClpP-like protease 0.0083 0.0259 0.0804
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0214 0.1181
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0265
Brugia malayi hypothetical protein 0.0033 0.0054 0.0167
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0405
Echinococcus multilocularis peregrin 0.0061 0.017 0.0169
Mycobacterium ulcerans esterase/lipase LipP 0.0292 0.1112 0.3456
Brugia malayi AMP-binding enzyme family protein 0.007 0.0206 0.064
Brugia malayi hypothetical protein 0.0032 0.0052 0.016
Plasmodium falciparum thioredoxin reductase 0.0079 0.0241 0.6063
Plasmodium vivax SET domain protein, putative 0.006 0.0166 0.142
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0347 0.1166
Brugia malayi Bromodomain containing protein 0.0061 0.017 0.0526
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.0214 0.1181
Trichomonas vaginalis importin beta-1, putative 0.0094 0.0302 0.1663
Brugia malayi MH1 domain containing protein 0.0024 0.0019 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0166 0.0333
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.0206 0.064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0166 0.0333
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0206 0.1195
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0163 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0174 0.054
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0064 0.0182 0.1566
Echinococcus multilocularis lamin 0.0027 0.0031 0.003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0093 0.0186
Toxoplasma gondii exonuclease III APE 0.0059 0.0163 0.1395
Echinococcus multilocularis cpg binding protein 0.0092 0.0294 0.0293
Echinococcus granulosus snurportin 1 0.1232 0.4952 0.9982
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0214 0.1181
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0292 0.1112 0.2244
Brugia malayi AMP-binding enzyme family protein 0.007 0.0206 0.064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0163 0.0546
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0245 0.0493
Brugia malayi hypothetical protein 0.005 0.0125 0.0386
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.0661 0.3532
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0142 0.0142
Onchocerca volvulus 0.0464 0.1816 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0056 0.0174
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0169 0.0525
Loa Loa (eye worm) hypothetical protein 0.007 0.0206 0.0416
Schistosoma mansoni hypothetical protein 0.0058 0.0155 0.0311
Loa Loa (eye worm) TAR-binding protein 0.0061 0.017 0.0342
Plasmodium vivax glutathione reductase, putative 0.0079 0.0241 0.2102
Schistosoma mansoni acetyl-CoA synthetase 0.007 0.0206 0.0415
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0206 0.064
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0347 0.3085
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0087 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.003 0.0163
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0016 0.0032
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0093 0.0186
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0201 0.0404
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.007 0.0206 0.0273
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0087 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0418 0.1629 0.3283
Loa Loa (eye worm) hypothetical protein 0.0099 0.0323 0.0651
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0347 0.0698
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.007 0.0206 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0174 0.054
Brugia malayi latrophilin 2 splice variant baaae 0.0308 0.118 0.3667
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.004 0.0079
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0163 0.1445
Plasmodium falciparum phd finger protein, putative 0.0058 0.0155 0.382
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0214 0.1181
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0347 0.1166
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0501 0.1008
Schistosoma mansoni inositol transporter 0.0113 0.0383 0.0771
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0173
Brugia malayi glutathione reductase 0.0079 0.0241 0.0747
Loa Loa (eye worm) hypothetical protein 0.0123 0.0424 0.0854
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0143 0.0503 0.0502
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0054 0.0054
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0031 0.0271
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0125 0.3026
Onchocerca volvulus 0.006 0.0166 0.0761
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1232 0.4952 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.007 0.0206 0.0693
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0174 0.035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0108
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0163 0.0328
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0022 0.0073
Schistosoma mansoni jumonji domain containing protein 0.015 0.0532 0.1071
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.0241 0.0809
Loa Loa (eye worm) hypothetical protein 0.0083 0.0259 0.0522
Brugia malayi kap beta 3 protein 0.0022 0.0009 0.0026
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0199 0.0734 0.0973
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.004 0.0039
Echinococcus multilocularis snurportin 1 0.1232 0.4952 0.4952
Brugia malayi GH02984p 0.0113 0.0383 0.1189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0102
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0163 0.0546
Trichomonas vaginalis penicillin-binding protein, putative 0.0292 0.1112 0.612
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Brugia malayi CXXC zinc finger family protein 0.0087 0.0274 0.085
Loa Loa (eye worm) glutathione reductase 0.0079 0.0241 0.0485
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0125 0.1049
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Loa Loa (eye worm) hypothetical protein 0.0308 0.118 0.2381
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.0206 0.0273
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0114 0.2747
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0347 0.0698
Trichomonas vaginalis sucrase-isomaltase, putative 0.0072 0.0214 0.1181
Loa Loa (eye worm) Smad1 0.0024 0.0019 0.0036
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.017 0.0526
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Echinococcus granulosus pyruvate kinase 0.0033 0.0056 0.0113
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.003 0.0163
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0064 0.0182 0.0181
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0056 0.0074
Entamoeba histolytica hypothetical protein 0.0441 0.1723 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0174 0.054
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0179 0.0652 0.0864
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0174 0.035
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0019 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0174 0.054
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0096 0.0191
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0089 0.0787
Mycobacterium leprae Probable lipase LipE 0.0292 0.1112 0.3716
Echinococcus granulosus expressed conserved protein 0.0093 0.0298 0.06
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0347 0.0346
Echinococcus granulosus beta LACTamase domain containing family member 0.0292 0.1112 0.224
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0311 0.0625
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0015
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.007 0.0206 0.0273
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0206 0.0273
Schistosoma mansoni sodium/solute symporter 0.0113 0.0383 0.0771
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0274 0.0552
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0174 0.035
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0347 0.0699
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0031 0.02
Schistosoma mansoni smad1 5 8 and 0.0024 0.0019 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0143 0.0503 0.1562
Mycobacterium ulcerans beta-lactamase 0.0292 0.1112 0.3456
Brugia malayi AMP-binding enzyme family protein 0.007 0.0206 0.064
Schistosoma mansoni intermediate filament proteins 0.0027 0.0031 0.0061
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0022 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0143 0.0503 0.1013
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0174 0.0174
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0737 0.293 1
Entamoeba histolytica hypothetical protein 0.0025 0.0022 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0122
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0405
Entamoeba histolytica hypothetical protein 0.0094 0.0302 0.175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0143 0.0503 0.1015
Loa Loa (eye worm) hypothetical protein 0.0099 0.0323 0.0651
Echinococcus granulosus pyruvate kinase 0.0033 0.0056 0.0113
Trichomonas vaginalis set domain proteins, putative 0.0464 0.1816 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Brugia malayi ecdysteroid receptor 0.0062 0.0174 0.054
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0225 0.0452
Brugia malayi nuclear receptor NHR-67 0.0029 0.004 0.0122
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.004 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0018 0.0084
Brugia malayi MH2 domain containing protein 0.0024 0.0019 0.0056
Brugia malayi Sodium:solute symporter family protein 0.0113 0.0383 0.1189
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0169 0.0525
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0746 0.2969 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0125 0.1105
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0096 0.0785
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0001 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0163 0.4685
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0093 0.0187
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.004 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0115 0.0634
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1049 0.5774
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0174 0.035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0114 0.0952
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0174 0.0809
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0347 0.1182
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0031 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Brugia malayi jmjC domain containing protein 0.0075 0.0225 0.0697
Echinococcus multilocularis musashi 0.0027 0.0031 0.003
Onchocerca volvulus 0.0188 0.0688 0.3684
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0087 0.0086
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0323 0.1002
Schistosoma mansoni Smad4 0.0024 0.0019 0.0036
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0113 0.0383 0.0771
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0102
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0163 0.0504
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1864 0.7535 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0174 0.054
Onchocerca volvulus 0.0078 0.0239 0.1172
Schistosoma mansoni hypothetical protein 0.1234 0.4961 1
Schistosoma mansoni cpg binding protein 0.0092 0.0294 0.0591
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0166 0.0333
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0126 0.0422
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0347 0.0698
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0174 0.0351
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.003 0.0163
Schistosoma mansoni hypothetical protein 0.0143 0.0503 0.1013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0114 0.0113
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.0206 0.064
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0093 0.0186
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0031 0.0095
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0022 0.0009 0.0075
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0311 0.1573
Trypanosoma brucei acetyl-CoA synthetase, putative 0.007 0.0206 0.1834
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0173
Brugia malayi Cytochrome P450 family protein 0.0048 0.0115 0.0356
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0206 0.064
Echinococcus multilocularis high affinity choline transporter 1 0.0113 0.0383 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1049 0.5774
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0089 0.0298
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0199 0.0734 0.0973
Leishmania major GTP-binding protein, putative 0.0064 0.0182 0.0618
Brugia malayi AMP-binding enzyme family protein 0.0807 0.3216 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0451 0.1763 0.5481
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.0206 0.0273
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0292 0.1112 0.1475
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0174 0.0351
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.004 0.0079
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0001 0.0003
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.003 0.0258
Schistosoma mansoni ap endonuclease 0.0059 0.0163 0.0327
Echinococcus multilocularis lamin dm0 0.0027 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0292 0.1112 0.2244
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0517 0.1607
Loa Loa (eye worm) kap beta 3 protein 0.0022 0.0009 0.0017
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0113 0.0383 0.0382
Echinococcus multilocularis protein dispatched 1 0.0048 0.0117 0.0117
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0113 0.0383 0.339
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0169 0.0169
Brugia malayi intermediate filament protein 0.0027 0.0031 0.0095
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0323 0.1871
Schistosoma mansoni transcription factor LCR-F1 0.0441 0.1723 0.3473
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.0404 0.1378
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0037 0.0252
Schistosoma mansoni rab6-interacting 0.0041 0.0087 0.0174
Schistosoma mansoni hypothetical protein 0.0308 0.118 0.2377
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0292 0.1112 0.3456
Onchocerca volvulus 0.0041 0.0087 0.0322
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0096 0.0785
Loa Loa (eye worm) beta-lactamase 0.0292 0.1112 0.2244
Brugia malayi beta-lactamase family protein 0.0292 0.1112 0.3456
Brugia malayi PHD-finger family protein 0.0058 0.0155 0.048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0418 0.1629 0.5065
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0064 0.0182 0.1614
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0031 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1049 0.5774
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.004 0.0079
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.007 0.0206 0.064
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.004 0.0057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0169 0.034
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0174 0.035
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0054 0.0167
Echinococcus granulosus neutral alpha glucosidase AB 0.0072 0.0214 0.0431
Echinococcus granulosus sodium:glucose cotransporter 0.0113 0.0383 0.0771
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0174 0.035
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0311 0.18
Echinococcus granulosus importin 5 0.0022 0.0009 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Schistosoma mansoni hypothetical protein 0.0022 0.0012 0.0022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0072 0.0214 0.1864
Schistosoma mansoni eyes absent homolog 0.0086 0.027 0.0542
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.1123 0.378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0174 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0174 0.035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.004 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0174 0.035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0031 0.0062
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.0404 0.0814
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0155 0.1324
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0104
Schistosoma mansoni nuclear hormone receptor 0.0029 0.004 0.0079
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 0.0804
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0174 0.054
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0311 0.0626
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0064 0.0182 0.4519
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.0404 0.0814
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0114 0.0387
Mycobacterium tuberculosis Probable hydrolase 0.0292 0.1112 0.1475
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0206 0.064
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Echinococcus multilocularis importin subunit beta 1 0.0115 0.0391 0.0391
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0259 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0206 0.1195
Mycobacterium tuberculosis Conserved protein 0.0292 0.1112 0.1475
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.004 0.0122
Toxoplasma gondii thioredoxin reductase 0.0079 0.0241 0.2102
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0114 0.0382
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0189 0.069 0.139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0418 0.1629 0.3283
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Trichomonas vaginalis penicillin-binding protein, putative 0.0292 0.1112 0.612
Leishmania major hypothetical protein, conserved 0.005 0.0125 0.0423
Echinococcus granulosus dnaJ subfamily B 0.1234 0.4961 1
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0056 0.0498
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0214 0.1181
Chlamydia trachomatis pyruvate kinase 0.0033 0.0056 0.1114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0174 0.035
Brugia malayi MH2 domain containing protein 0.0024 0.0019 0.0056
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.0241 0.0485
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0142 0.0365
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.003 0.009
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0204 0.0204
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0008 0.0024
Echinococcus granulosus jumonji domain containing protein 0.008 0.0247 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0174 0.0351
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0347 0.1182
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0174 0.0174
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0054 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0292 0.1112 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.003 0.0168
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0174 0.054
Loa Loa (eye worm) hypothetical protein 0.007 0.0206 0.0416
Echinococcus multilocularis pyruvate kinase 0.0026 0.0028 0.0027
Echinococcus granulosus importin subunit beta 1 0.0115 0.0391 0.0787
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.004 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0166 0.0333
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0206 0.0273
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0114 0.0952
Brugia malayi hypothetical protein 0.0041 0.0087 0.0269
Brugia malayi MH1 domain containing protein 0.0024 0.0019 0.0056
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0179 0.0652 0.0864
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.007 0.0206 0.0273
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.0206 0.064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0206 0.064
Loa Loa (eye worm) hypothetical protein 0.0086 0.027 0.0543
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0114 0.0952
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0179 0.0652 0.2126
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0072 0.0214 0.0432
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0323 0.065
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0031 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0206 0.0586
Loa Loa (eye worm) hypothetical protein 0.007 0.0206 0.0416
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0206 0.0273
Echinococcus granulosus neuropeptide s receptor 0.0476 0.1867 0.3762
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0089 0.0298
Echinococcus multilocularis tar DNA binding protein 0.0061 0.017 0.0169
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0418 0.1629 0.3283
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0807 0.3216 0.6494
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.0214 0.0665
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0056 0.0174
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0054 0.0108
Onchocerca volvulus 0.0292 0.1112 0.6056
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0292 0.1112 0.1475
Echinococcus multilocularis transportin 1 0.0022 0.0009 0.0008
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0016 0.0016
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.0206 0.064
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0022 0.0009 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0174 0.0174
Brugia malayi acetyl-Coenzyme A synthetase 2 0.007 0.0206 0.064
Brugia malayi RNA binding protein 0.0061 0.017 0.0526
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0056 0.0113
Schistosoma mansoni hypothetical protein 0.0143 0.0503 0.1013
Brugia malayi hypothetical protein 0.0033 0.0054 0.0167
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0023 0.0014 0.012
Schistosoma mansoni kinase 0.0049 0.012 0.0241
Entamoeba histolytica HEAT repeat domain containing protein 0.0022 0.0009 0.0049
Loa Loa (eye worm) hypothetical protein 0.0123 0.0424 0.0854
Entamoeba histolytica Ran family GTPase 0.0064 0.0182 0.1051
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0094 0.0302 0.1663
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0113
Brugia malayi Nuclear hormone receptor E75 0.0029 0.004 0.0122
Schistosoma mansoni alpha-glucosidase 0.028 0.1063 0.2141
Leishmania major acetyl-CoA synthetase, putative 0.007 0.0206 0.0703
Mycobacterium ulcerans hypothetical protein 0.0155 0.0553 0.1719
Brugia malayi nuclear receptor NHR-88 0.0029 0.004 0.0122
Schistosoma mansoni coup transcription factor 0.0062 0.0174 0.035
Loa Loa (eye worm) hypothetical protein 0.0143 0.0503 0.1015
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0311 0.0964
Entamoeba histolytica hypothetical protein 0.0441 0.1723 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0169 0.034
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0259 0.227
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0054 0.0167
Echinococcus granulosus GTP binding nuclear protein Ran 0.0064 0.0182 0.0365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0022 0.0067
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0155 0.0311
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.007 0.0206 0.179
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.004 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0102
Loa Loa (eye worm) hypothetical protein 0.0292 0.1112 0.2244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.004 0.0079
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0347 0.3063
Loa Loa (eye worm) hypothetical protein 0.0292 0.1112 0.2244
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0114 0.0113
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0245 0.0244
Schistosoma mansoni nuclear receptor 0.0029 0.004 0.0079
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 0.6548
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0174 0.054
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0125 0.1049
Brugia malayi hypothetical protein 0.0123 0.0424 0.1315
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0201 0.02
Echinococcus multilocularis lysosomal alpha glucosidase 0.0325 0.1248 0.1247
Brugia malayi hypothetical protein 0.0441 0.1723 0.5357
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0114 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Mycobacterium leprae conserved hypothetical protein 0.0292 0.1112 0.3716
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0489 0.1668
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0746 0.2969 0.2969
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0259 0.0769
Onchocerca volvulus 0.007 0.0206 0.099
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Brugia malayi jmjC domain containing protein 0.0189 0.069 0.2144
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0329 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0093 0.0511
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.004 0.0079
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0087 0.0708
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 0.0804
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Schistosoma mansoni hypothetical protein 0.1232 0.4952 0.9982
Echinococcus granulosus peregrin 0.0061 0.017 0.0341
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Brugia malayi PHD-finger family protein 0.0024 0.0017 0.0051
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.1867 0.3762
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0388 0.0388
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0206 0.0586
Toxoplasma gondii hypothetical protein 0.0047 0.0114 0.0951
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0031 0.0171
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0054 0.0108
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0807 0.3216 1
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1049 0.5774
Echinococcus granulosus sodium:glucose cotransporter 2 0.0113 0.0383 0.0771
Schistosoma mansoni cpg binding protein 0.0087 0.0274 0.0551
Plasmodium falciparum glutathione reductase 0.0027 0.0031 0.0577
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0031 0.02
Brugia malayi RNA, U transporter 1 0.0328 0.126 0.3918
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.004 0.0122
Onchocerca volvulus 0.007 0.0206 0.099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0149 0.0299
Loa Loa (eye worm) AMP-binding enzyme family protein 0.007 0.0206 0.0416
Onchocerca volvulus 0.0029 0.004 0.0057
Toxoplasma gondii ABC1 family protein 0.0292 0.1112 1
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Echinococcus multilocularis protein patched 0.0042 0.0093 0.0092
Brugia malayi conserved hypotetical protein 0.0029 0.004 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0451 0.1763 0.3559
Onchocerca volvulus 0.0027 0.0031 0.0009
Loa Loa (eye worm) hypothetical protein 0.0292 0.1112 0.2244
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0081 0.0466
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0347 0.1909
Leishmania major alpha glucosidase II subunit, putative 0.0072 0.0214 0.073
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0206 0.0273
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0174 0.0174
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0206 0.1195
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.0182 0.061
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0155 0.0312
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0201 0.0405
Echinococcus multilocularis Smad4 0.0024 0.0019 0.0018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0163 0.5774
Schistosoma mansoni patched 1 0.0042 0.0093 0.0186
Leishmania major pyruvate kinase 0.0033 0.0056 0.0191
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0037 0.0727
Schistosoma mansoni alpha-glucosidase 0.028 0.1063 0.2141
Schistosoma mansoni inositol transporter 0.0113 0.0383 0.0771
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0142 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.0404 0.1255
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.1587 0.3204
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Schistosoma mansoni lipoxygenase 0.0041 0.0087 0.0174
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.003 0.0163
Toxoplasma gondii HEAT repeat-containing protein 0.0115 0.0391 0.3466
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0031 0.0271
Loa Loa (eye worm) DR-78 0.0029 0.004 0.0079
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.004 0.0122
Brugia malayi follicle stimulating hormone receptor 0.024 0.0901 0.2802
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0553 0.0734
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0016 0.0032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0451 0.1763 0.3559
Brugia malayi AMP-binding enzyme family protein 0.007 0.0206 0.064
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0016 0.0015
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.007 0.0206 0.0693
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0115 0.0634
Brugia malayi MAP kinase sur-1 0.0104 0.0347 0.1077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0102
Schistosoma mansoni ran 0.0064 0.0182 0.0365
Trypanosoma brucei importin beta-1 subunit, putative 0.0115 0.0391 0.3481
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0031 0.0062
Onchocerca volvulus 0.0041 0.0087 0.0322
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.1867 0.1866
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1049 0.5774
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.0241 0.0319
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0169 0.0577
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.1371 0.2767
Plasmodium falciparum thioredoxin reductase 0.0027 0.0031 0.0577
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0019 0.0018
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0201 0.02
Mycobacterium ulcerans hypothetical protein 0.0292 0.1112 0.3456
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.0206 0.0586
Toxoplasma gondii propionate-CoA ligase 0.007 0.0206 0.179
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0114 0.0353
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0169 0.0224
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0169 0.034
Echinococcus granulosus high affinity choline transporter 1 0.0113 0.0383 0.0771
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0292 0.1112 0.1475
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0015 0.0084
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0214 0.1181
Mycobacterium ulcerans lipase LipD 0.0292 0.1112 0.3456
Mycobacterium tuberculosis Probable lipase LipD 0.0292 0.1112 0.1475
Brugia malayi tailless protein 0.0029 0.004 0.0122
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0087 0.0174
Echinococcus multilocularis GPCR, family 2 0.0143 0.0503 0.0502
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0125 0.0418
Loa Loa (eye worm) RNA binding protein 0.0061 0.017 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0174 0.0351
Plasmodium falciparum pyruvate kinase 0.0033 0.0056 0.1242
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0114 0.0229
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0259 0.0521
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0018 0.0243
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0019 0.0036
Echinococcus granulosus long chain fatty acid transport protein 4 0.0746 0.2969 0.5985
Plasmodium vivax importin-beta 2, putative 0.0115 0.0391 0.3466
Loa Loa (eye worm) hypothetical protein 0.0113 0.0383 0.0772
Onchocerca volvulus Huntingtin homolog 0.0123 0.0424 0.2205
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0056 0.0431
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.007 0.0206 0.064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0031 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0061 0.017 0.0341
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0325 0.1248 0.2519
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0031 0.02
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0174 0.054
Echinococcus granulosus geminin 0.1178 0.4733 0.954
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0174 0.035
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.0206 0.0273
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0174 0.054
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0347 0.0346
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0259 1
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0701 0.3857
Trichomonas vaginalis D-aminoacylase, putative 0.0292 0.1112 0.612
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0094 0.0302 0.1663
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0031 0.0577
Echinococcus granulosus Smad4 0.0024 0.0019 0.0036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0325 0.1248 0.3879
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0108
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0179 0.0652 0.0864
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0174 0.0351
Giardia lamblia PHD finger protein 15 0.0058 0.0155 0.446
Schistosoma mansoni hypothetical protein 0.0143 0.0503 0.1013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0163 0.0942
Trichomonas vaginalis hypothetical protein 0.0022 0.0009 0.0049
Leishmania major pyruvate kinase 0.0033 0.0056 0.0191
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Schistosoma mansoni high-affinity choline transporter 0.0113 0.0383 0.0771
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0056 0.0151
Trypanosoma brucei protein kinase, putative 0.0104 0.0347 0.3085
Schistosoma mansoni ap endonuclease 0.0059 0.0163 0.0327
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0737 0.293 0.3887
Brugia malayi steroid hormone receptor 0.0062 0.0174 0.054
Brugia malayi beta-lactamase 0.0292 0.1112 0.3456
Echinococcus multilocularis lysosomal alpha glucosidase 0.0325 0.1248 0.1247
Loa Loa (eye worm) hypothetical protein 0.0292 0.1112 0.2244
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0311 0.0625
Schistosoma mansoni hypothetical protein 0.0143 0.0503 0.1013
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0206 0.0703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0418 0.1629 0.3283
Brugia malayi Importin beta-1 subunit 0.0115 0.0391 0.1215
Brugia malayi nuclear receptor NHR-88 0.0062 0.0174 0.054
Leishmania major hypothetical protein, conserved 0.0292 0.1112 0.3794
Entamoeba histolytica hypothetical protein 0.0441 0.1723 1
Echinococcus multilocularis expressed conserved protein 0.0093 0.0298 0.0298
Schistosoma mansoni importin-beta 2 0.0022 0.0009 0.0017
Echinococcus multilocularis geminin 0.1178 0.4733 0.4733
Plasmodium falciparum acetyl-CoA synthetase, putative 0.007 0.0206 0.5165
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0174 0.035
Loa Loa (eye worm) hypothetical protein 0.007 0.0206 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0174 0.054
Schistosoma mansoni FFA transport protein 0.0746 0.2969 0.5985
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0056 0.0174
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.0206 0.0273
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0901 0.1819
Echinococcus granulosus lysosomal alpha glucosidase 0.0325 0.1248 0.2514
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0102
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0388 0.0781
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0022 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0031 0.0271
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0174 0.035
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0037 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.0614 0.5485
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0031 0.0577
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0174
Echinococcus granulosus acetylcholinesterase 0.0069 0.0201 0.0404
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0096 0.0526
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.007 0.0206 0.0703
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0701 0.3857
Echinococcus granulosus lamin 0.0027 0.0031 0.0061
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0087 0.2044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0174 0.054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0163 0.1395
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0056 0.0431
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0292 0.1112 0.224
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.004 0.0079
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.1123 0.3831
Loa Loa (eye worm) hypothetical protein 0.0113 0.0383 0.0772
Brugia malayi Thioredoxin reductase 0.0079 0.0241 0.0747
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0142 0.0286
Loa Loa (eye worm) hypothetical protein 0.0086 0.027 0.0543
Brugia malayi nuclear receptor RXR 0.0033 0.0054 0.0167
Brugia malayi isocitrate dehydrogenase 0.0048 0.0114 0.0353
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0347 0.1166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0292 0.1112 0.224
Schistosoma mansoni hypothetical protein 0.1178 0.4733 0.954
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.025
Mycobacterium tuberculosis Probable esterase LipL 0.0292 0.1112 0.1475
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0113 0.0383 0.0382
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0418 0.1629 0.3283
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0108
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0038 0.0037
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0259 0.227
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0022 0.0193
Trypanosoma brucei importin beta-1 subunit, putative 0.0115 0.0391 0.3481
Mycobacterium tuberculosis Conserved protein 0.0292 0.1112 0.1475
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0206 0.064
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.1371 0.2767
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0174 0.0809
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0174 0.035
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.007 0.0206 0.0415
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0019 0.0036
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.0404 0.0536
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0163 0.4025
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0206 0.0703
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0064 0.0182 0.0366
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.003 0.0163
Mycobacterium tuberculosis Probable oxidoreductase 0.0199 0.0734 0.0973
Echinococcus multilocularis pyruvate kinase 0.0033 0.0056 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0661 0.3637
Leishmania major importin beta-1 subunit, putative 0.0094 0.0302 0.1029
Trichomonas vaginalis antibiotic synthetase, putative 0.007 0.0206 0.1136
Schistosoma mansoni tar DNA-binding protein 0.0061 0.017 0.0341
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.007 0.0206 0.1834
Giardia lamblia Pyruvate kinase 0.0033 0.0056 0.1613
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0174 0.035
Echinococcus granulosus GPCR family 2 0.0143 0.0503 0.1013
Brugia malayi nuclear receptor RXR 0.0029 0.004 0.0122
Onchocerca volvulus 0.0029 0.004 0.0057
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.007 0.0206 0.179
Brugia malayi nuclear hormone receptor 0.0062 0.0174 0.054
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0031 0.0104
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0031 0.0095
Brugia malayi Nuclear hormone receptor E75 0.0029 0.004 0.0122
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0166 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.1112 0.3743
Mycobacterium tuberculosis Probable lipase LipE 0.0292 0.1112 0.1475
Loa Loa (eye worm) hypothetical protein 0.006 0.0166 0.0333
Schistosoma mansoni lamin 0.0027 0.0031 0.0061
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0155 0.0154
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0163 0.0554
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.007 0.0206 0.0693
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0031 0.0271
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.004 0.0079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.0182 0.061
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0079
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0031 0.0104
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0114 0.101
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0496 0.0495
Schistosoma mansoni importin beta-1 0.0115 0.0391 0.0787
Loa Loa (eye worm) oxidoreductase 0.007 0.0206 0.0416
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0441 0.1723 0.3473
Trichomonas vaginalis D-aminoacylase, putative 0.0292 0.1112 0.612
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0173
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0489 0.1645
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0174 0.054
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0031 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0174 0.0351
Trypanosoma cruzi importin beta-1 subunit, putative 0.0094 0.0302 0.1015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0174 0.035
Brugia malayi TAR-binding protein 0.0061 0.017 0.0526
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0093 0.0092
Brugia malayi MH2 domain containing protein 0.0355 0.1371 0.426
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.003 0.0163
Brugia malayi Smad1 0.0024 0.0019 0.0056
Brugia malayi hypothetical protein 0.0029 0.004 0.0122
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0031 0.0879
Brugia malayi Carboxylesterase family protein 0.0069 0.0201 0.0623
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.1123 0.378
Echinococcus multilocularis neutral alpha glucosidase AB 0.0072 0.0214 0.0214
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.004 0.0079
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0225 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0174 0.054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0143 0.0503 0.1562
Echinococcus granulosus translational activator gcn1 0.0022 0.0009 0.0017
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0019 0.0036
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0173
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0201 0.0404
Brugia malayi Pre-SET motif family protein 0.006 0.0166 0.0513
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0001 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0441 0.1723 0.1723
Loa Loa (eye worm) hypothetical protein 0.0062 0.0174 0.0351
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0163 0.5774
Brugia malayi Pre-SET motif family protein 0.0408 0.1587 0.4934
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0012 0.0022
Plasmodium falciparum importin beta, putative 0.0115 0.0391 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0056 0.0151
Onchocerca volvulus 0.0292 0.1112 0.6056
Schistosoma mansoni lipoxygenase 0.0115 0.0388 0.0781
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0311 0.171
Echinococcus multilocularis beta LACTamase domain containing family member 0.0292 0.1112 0.1111
Echinococcus multilocularis smad 0.0024 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0042 0.0093 0.0186
Schistosoma mansoni loxhd1 0.0041 0.0087 0.0174
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0087 0.0175
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0016 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0292 0.1112 0.612
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0214 0.1242
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0347 0.1166
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0111 0.0372 0.0749
Trichomonas vaginalis esterase, putative 0.0292 0.1112 0.612
Trichomonas vaginalis antibiotic synthetase, putative 0.007 0.0206 0.1136
Schistosoma mansoni cpg binding protein 0.0092 0.0294 0.0591
Schistosoma mansoni tar DNA-binding protein 0.0061 0.017 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1049 0.5774
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.004 0.0079
Loa Loa (eye worm) importin-beta domain-containing protein 0.0022 0.0009 0.0017
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0056 0.0311
Echinococcus granulosus solute carrier family 5 0.0113 0.0383 0.0771
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0214 0.1181
Brugia malayi Carboxylesterase family protein 0.0069 0.0201 0.0623
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0496 0.0998
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0451 0.1763 0.5481
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0031 0.02
Echinococcus granulosus transportin 1 0.0022 0.0009 0.0017
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0259 0.0521
Echinococcus granulosus smad 0.0024 0.0019 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0174 0.035
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0114 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0347 0.1909

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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