Detailed information for compound 803723

Basic information

Technical information
  • TDR Targets ID: 803723
  • Name: 1-[2-[(2,3-dimethylphenyl)amino]-2-oxoethyl]t riazole-4,5-dicarboxylic acid
  • MW: 318.285 | Formula: C14H14N4O5
  • H donors: 3 H acceptors: 7 LogP: 1.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1C)C)Cn1nnc(c1C(=O)O)C(=O)O
  • InChi: 1S/C14H14N4O5/c1-7-4-3-5-9(8(7)2)15-10(19)6-18-12(14(22)23)11(13(20)21)16-17-18/h3-5H,6H2,1-2H3,(H,15,19)(H,20,21)(H,22,23)
  • InChiKey: WOVSGDAOZHGLIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[2-[(2,3-dimethylphenyl)amino]-2-oxo-ethyl]triazole-4,5-dicarboxylic acid
  • 1-[2-[(2,3-dimethylphenyl)amino]-2-keto-ethyl]triazole-4,5-dicarboxylic acid
  • 1-[2-[(2,3-dimethylphenyl)amino]-2-oxo-ethyl]-1,2,3-triazole-4,5-dicarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0012 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.3536 0.3528
Echinococcus granulosus zinc finger protein 0.0053 0.0299 0.0288
Schistosoma mansoni hypothetical protein 0.0046 0.0252 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.0005
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.006 0.1838
Trypanosoma cruzi ISWI complex protein 0.0034 0.016 0.0682
Schistosoma mansoni kinase 0.0151 0.1055 0.1045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0155 0.0144
Loa Loa (eye worm) glutaminase 0.0274 0.2003 0.2429
Echinococcus granulosus ETHE1 protein 0.0016 0.0014 0.0003
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0014 0.001
Schistosoma mansoni caspase-3 (C14 family) 0.0117 0.0797 0.0787
Schistosoma mansoni ferritin light chain 0.0026 0.0092 0.008
Brugia malayi hypothetical protein 0.0051 0.029 0.0339
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0014 0.0003
Schistosoma mansoni hypothetical protein 0.0047 0.0255 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0255 0.0244
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0014 0.001
Plasmodium falciparum cytosolic glyoxalase II 0.0016 0.0014 0.0081
Entamoeba histolytica hypothetical protein 0.0037 0.0176 0.0773
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0394 0.1757
Trypanosoma cruzi ISWI complex protein 0.0034 0.016 0.0682
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0047 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1025 0.4672
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0996 0.1962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0255 0.0244
Schistosoma mansoni tsg101-related 0.0149 0.1038 0.1028
Echinococcus granulosus ETS domain containing protein Elk 1 0.0022 0.0068 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0236 0.1026
Trypanosoma brucei ISWI complex protein 0.0034 0.016 0.0734
Giardia lamblia Kinase, PLK 0.0297 0.2177 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0173 0.0317
Echinococcus granulosus Smad4 0.0034 0.0155 0.0144
Onchocerca volvulus 0.0016 0.0014 0.0004
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.006 0.0049
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0014 0.0004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0018 0.0028
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0143 0.0993 0.0983
Brugia malayi MH2 domain containing protein 0.0034 0.0155 0.0175
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0154 0.1076 0.4914
Entamoeba histolytica hypothetical protein 0.0037 0.0176 0.0773
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.019 0.0179
Trypanosoma cruzi glyoxalase II 0.0016 0.0014 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0217
Loa Loa (eye worm) hypothetical protein 0.0957 0.7245 0.8821
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0173 0.0197
Echinococcus multilocularis ETS transcription factor Elf 2 0.0022 0.0068 0.0057
Schistosoma mansoni ferritin light chain 0.0026 0.0092 0.008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0155 0.0649
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0398 0.0471
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0173 0.0197
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0014 0.0003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0044 0.0236 0.0225
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.0276
Mycobacterium tuberculosis Conserved protein 0.0036 0.0173 0.0317
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0236 0.1115
Echinococcus multilocularis ETHE1 protein 0.0016 0.0014 0.0003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Brugia malayi F/Y-rich N-terminus family protein 0.005 0.0278 0.0325
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0487 0.0476
Loa Loa (eye worm) hypothetical protein 0.0132 0.0913 0.11
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0001
Schistosoma mansoni myst-related protein 0.0022 0.0063 0.0052
Trypanosoma cruzi metacaspase, putative 0.0044 0.0236 0.1036
Trypanosoma brucei unspecified product 0.002 0.0047 0.0217
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0014 0.0003
Brugia malayi hypothetical protein 0.0366 0.2705 0.3285
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0047 0.0066
Echinococcus granulosus microtubule associated protein 2 0.0698 0.526 0.5254
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.029 0.1368
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0047 0.0152
Schistosoma mansoni bromodomain containing protein 0.0151 0.1055 0.1045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0399 0.0768
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0149 0.0684
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0399 0.0388
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0047 0.0036
Brugia malayi Bromodomain containing protein 0.0177 0.1257 0.1519
Trichomonas vaginalis ran, putative 0.0021 0.006 0.0212
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0077 0.029
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0333 0.0322
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0399 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Brugia malayi hypothetical protein 0.0041 0.0213 0.0246
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0016 0.0014 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0236 0.8106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0012 0.0001
Trichomonas vaginalis hypothetical protein 0.0107 0.0714 0.3233
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0014 0.0003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0698 0.0837
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0126 0.0592
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0016 0.0014 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0155 0.0649
Loa Loa (eye worm) fli-1 protein 0.0471 0.3511 0.4268
Brugia malayi RNA, U transporter 1 0.0083 0.0533 0.0636
Echinococcus granulosus mixed lineage leukemia protein mll 0.0037 0.018 0.0169
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0255 0.0244
Brugia malayi Ets-domain containing protein 0.0155 0.1086 0.1311
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0173 0.0794
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0047 0.0066
Echinococcus granulosus methyl CpG binding domain protein 2 0.0038 0.019 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0432 0.0513
Echinococcus multilocularis Smad4 0.0034 0.0155 0.0144
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.019 0.0179
Onchocerca volvulus 0.0036 0.0173 0.0223
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0014 0.0004
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0016 0.0014 0.001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0154 0.1076 0.4909
Echinococcus granulosus kelch ECH associated protein 1 like 0.0202 0.1449 0.1439
Brugia malayi jmjC domain containing protein 0.007 0.0432 0.0513
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.3536 0.3528
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0089 0.058 0.0694
Giardia lamblia DINP protein human, muc B family 0.002 0.0047 0.0152
Loa Loa (eye worm) hypothetical protein 0.0133 0.0914 0.11
Schistosoma mansoni zinc finger protein 0.0034 0.016 0.0149
Schistosoma mansoni ets 0.0022 0.0068 0.0057
Trypanosoma brucei metacaspase 5, putative 0.0044 0.0236 0.1086
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0162
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0018 0.0007
Leishmania major metallo-beta-lactamase family protein-like protein 0.0016 0.0014 0.001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0037 0.018 0.0169
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0173 0.0317
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.0236 0.1036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0197
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0012 0.0001
Trypanosoma cruzi glyoxalase II 0.0016 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0197
Trypanosoma brucei beta lactamase 0.0198 0.1418 0.651
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0034 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0155 0.0649
Brugia malayi ethe1-prov protein 0.0016 0.0014 0.0004
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0059 0.035 0.0339
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0236 0.1026
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0126 0.4117
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.0236 0.1036
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1657 0.1648
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0197
Toxoplasma gondii ABC1 family protein 0.0036 0.0173 0.0814
Brugia malayi SET domain containing protein 0.0016 0.0019 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.2177 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0042 0.0215 0.0204
Brugia malayi hypothetical protein 0.0033 0.015 0.0169
Schistosoma mansoni ran 0.0021 0.006 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.029 0.1282
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0173 0.0162
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0154 0.1076 0.1066
Onchocerca volvulus Huntingtin homolog 0.0366 0.2705 0.3724
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0126 0.014
Loa Loa (eye worm) histone methyltransferase 0.0046 0.0249 0.029
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0013 0.0002
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0016 0.0014 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0018 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0007
Mycobacterium ulcerans glutaminase 0.0274 0.2003 0.3973
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0155 0.1086 0.1311
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0398 0.0471
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0198 0.1418 0.2803
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.006 0.0049
Onchocerca volvulus Huntingtin homolog 0.0366 0.2705 0.3724
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0154 0.1076 0.1066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0155 0.0144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0255 0.0298
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0126 0.0518
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Schistosoma mansoni Smad4 0.0034 0.0155 0.0144
Entamoeba histolytica hypothetical protein 0.0037 0.0176 0.0773
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.029 1
Schistosoma mansoni smad1 5 8 and 0.0034 0.0155 0.0144
Entamoeba histolytica hypothetical protein 0.0077 0.0487 0.2206
Trichomonas vaginalis helicase, putative 0.0034 0.0155 0.0649
Trypanosoma brucei Vps23 core domain containing protein, putative 0.007 0.0433 0.1986
Schistosoma mansoni caspase-7 (C14 family) 0.0117 0.0797 0.0787
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0042 0.0215 0.0204
Brugia malayi jmjC domain containing protein 0.0057 0.0333 0.0393
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0012 0.0001
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0092 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0002
Plasmodium falciparum metacaspase-like protein 0.0044 0.0236 0.8082
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0014 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0059 0.0048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0173 0.0317
Schistosoma mansoni zinc finger protein 0.0053 0.0299 0.0288
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0126 0.0592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Loa Loa (eye worm) CXXC zinc finger family protein 0.0149 0.104 0.1255
Brugia malayi hypothetical protein 0.0077 0.0487 0.058
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0155 0.0175
Loa Loa (eye worm) hypothetical protein 0.0086 0.0559 0.0667
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.018 0.0169
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0667 0.502 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0126 0.014
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0012 0.0001
Echinococcus granulosus kelch ECH associated protein 1 0.0202 0.1449 0.1439
Echinococcus granulosus fetal alzheimer antigen falz 0.0059 0.035 0.0339
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0201 0.0231
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0014 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0162
Echinococcus multilocularis zinc finger protein 0.0053 0.0299 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0398 0.0387
Schistosoma mansoni caspase-7 (C14 family) 0.0086 0.0554 0.0543
Schistosoma mansoni hypothetical protein 0.0022 0.0068 0.0057
Entamoeba histolytica hypothetical protein 0.0024 0.0077 0.0316
Schistosoma mansoni DNA helicase recq1 0.003 0.0126 0.0115
Echinococcus granulosus importin subunit beta 1 0.0029 0.0119 0.0108
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0126 0.0115
Loa Loa (eye worm) RNA binding protein 0.0065 0.0398 0.0471
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0047 0.0178
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0197
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0012 0.0055
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0012 0.0001
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0014 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0215 0.0204
Trypanosoma brucei glyoxalase II 0.0016 0.0014 0.0066
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0047 0.0162
Entamoeba histolytica hypothetical protein 0.0077 0.0487 0.2206
Entamoeba histolytica hypothetical protein 0.0077 0.0487 0.2206
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0173 0.0733
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0173 0.0317
Brugia malayi beta-lactamase 0.0036 0.0173 0.0197
Leishmania major hypothetical protein, conserved 0.0034 0.016 0.0682
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0092 0.0154
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0667 0.502 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0018 0.0215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0069
Brugia malayi Bromodomain containing protein 0.0086 0.0557 0.0666
Echinococcus multilocularis kelch ECH associated protein 1 0.0202 0.1449 0.1439
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0092 0.0154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0399 0.0388
Schistosoma mansoni hypothetical protein 0.0034 0.016 0.0149
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0014 0.0027
Mycobacterium tuberculosis Conserved protein 0.0036 0.0173 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0173 0.5848
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0016 0.0014 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0255 0.0298
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0154 0.1076 0.4909
Schistosoma mansoni apoferritin-2 0.0026 0.0092 0.008
Loa Loa (eye worm) hypothetical protein 0.0183 0.1299 0.157
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0012 0.0001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0399 0.1786
Echinococcus granulosus dna polymerase kappa 0.002 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0051 0.029 0.0339
Plasmodium falciparum importin beta, putative 0.0029 0.0119 0.3866
Onchocerca volvulus 0.0016 0.0014 0.0004
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0154 0.1076 0.4922
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0333 0.0322
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0154 0.1076 0.1066
Loa Loa (eye worm) D-ets-2 protein 0.0022 0.0068 0.0069
Leishmania major hypothetical protein, conserved 0.007 0.0433 0.1942
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0173 0.0317
Loa Loa (eye worm) hypothetical protein 0.0154 0.1076 0.1298
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0047 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0398 0.0387
Echinococcus granulosus caspase 0.0117 0.0797 0.0787
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0297 0.2177 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0022 0.0068 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Brugia malayi RNA binding protein 0.0065 0.0398 0.0471
Brugia malayi beta-lactamase family protein 0.0036 0.0173 0.0197
Loa Loa (eye worm) nuclear factor I 0.0019 0.0039 0.0034
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0012 0.0001
Schistosoma mansoni survival motor neuron protein 0.0047 0.0255 0.0244
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0014 0.0027
Brugia malayi Smad1 0.0034 0.0155 0.0175
Loa Loa (eye worm) hypothetical protein 0.0229 0.1657 0.2007
Echinococcus multilocularis ETS transcription factor Elf 5 0.0022 0.0068 0.0057
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0014 0.0027
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0038 0.019 0.0179
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0012 0.0001
Echinococcus multilocularis snurportin 1 0.0311 0.2288 0.2279
Echinococcus multilocularis expressed protein 0.0026 0.0092 0.008
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0154 0.1076 0.4942
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0119 0.0548
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Schistosoma mansoni ferritin 0.0026 0.0092 0.008
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0047 0.0152
Plasmodium falciparum metacaspase 1 0.0044 0.0236 0.8082
Schistosoma mansoni tsg101-related 0.0182 0.1294 0.1284
Echinococcus multilocularis caspase 8 0.0044 0.0236 0.0225
Trypanosoma cruzi ISWI complex protein 0.0016 0.0015 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0432 0.0421
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0014 0.0027
Echinococcus granulosus bloom syndrome protein 0.0044 0.0236 0.0225
Loa Loa (eye worm) hypothetical protein 0.0366 0.2705 0.3285
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.2177 0.2168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0255 0.0244
Loa Loa (eye worm) hypothetical protein 0.0044 0.0236 0.0274
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0065 0.0394 0.0467
Echinococcus granulosus muscleblind protein 0.1082 0.8212 0.821
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0399 0.0768
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0413 0.3067 0.6098
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0012 0.0001
Trypanosoma brucei metacaspase 0.0044 0.0236 0.1086
Brugia malayi serine/threonine-protein kinase plk-2 0.0297 0.2177 0.2641
Echinococcus multilocularis ETS transcription factor Elf 1 0.0022 0.0068 0.0057
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0155 0.0144
Echinococcus multilocularis kelch ECH associated protein 1 0.0202 0.1449 0.1439
Schistosoma mansoni elf1 0.0022 0.0068 0.0057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0126 0.014
Brugia malayi transcription factor E74 isoform 0.0022 0.0068 0.0069
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0095 0.0446
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0126 0.0115
Leishmania major metacaspase, putative 0.0044 0.0236 0.1036
Trichomonas vaginalis Sentrin-specific protease, putative 0.0065 0.0394 0.1757
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Loa Loa (eye worm) hypothetical protein 0.0219 0.1575 0.1907
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0173 0.0733
Leishmania major hypothetical protein, conserved 0.0036 0.0173 0.0743
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0126 0.0115
Plasmodium vivax unspecified product 0.0016 0.0014 0.0206
Echinococcus granulosus kelch ECH associated protein 1 like 0.0202 0.1449 0.1439
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0399 0.1888
Schistosoma mansoni smad 0.0034 0.0155 0.0144
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0149 0.0623
Mycobacterium leprae Probable lipase LipE 0.0036 0.0173 0.0317
Onchocerca volvulus 0.0041 0.0213 0.0279
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0149 0.0632
Plasmodium vivax JmjC domain containing protein 0.0015 0.0012 0.0126
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0027 0.01 0.3252
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0143 0.0993 0.0983
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0013 0.0021
Schistosoma mansoni DNA polymerase eta 0.002 0.0047 0.0036
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0092 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Loa Loa (eye worm) Smad1 0.0034 0.0155 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0213 0.0246
Onchocerca volvulus 0.0957 0.7245 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.0022 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0248
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0018 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.018 0.0169
Echinococcus multilocularis muscleblind protein 0.1082 0.8212 0.821
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Trypanosoma cruzi hypothetical protein 0.0065 0.0394 0.1766
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0022 0.0068 0.0057
Echinococcus multilocularis Kelch repeat type 1 0.0203 0.1453 0.1443
Entamoeba histolytica hypothetical protein 0.0022 0.0063 0.0253
Brugia malayi DNA-binding protein D-ETS-3 0.0022 0.0068 0.0069
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0047 0.0217
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0047 0.0066
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0003
Loa Loa (eye worm) hypothetical protein 0.0086 0.0554 0.0662
Trypanosoma brucei metacaspase MCA2 0.0044 0.0236 0.1086
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0236 0.1024
Schistosoma mansoni ferritin 0.0026 0.0092 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Echinococcus granulosus caspase 3 0.0073 0.0456 0.0445
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0399 0.0388
Schistosoma mansoni SET domain protein 0.0016 0.0019 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0015 0.0005
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0154 0.1076 0.1066
Echinococcus granulosus ewsr:fli fusion protein type 0.0022 0.0068 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0155 0.0649
Trypanosoma brucei polo-like protein kinase 0.0297 0.2177 1
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0092 0.06 0.0717
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.011 0.0099
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0018 0.0078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.0222
Chlamydia trachomatis ribonuclease Z 0.0016 0.0014 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Schistosoma mansoni gabp alpha 0.0155 0.1086 0.1076
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0297 0.2177 0.2168
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Echinococcus multilocularis caspase 3 0.0073 0.0456 0.0445
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0173 0.0733
Echinococcus multilocularis ubiquitin specific protease 41 0.0154 0.1076 0.1066
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0217
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0236 0.1115
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0119 0.0559
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0014 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0198 0.1418 0.2803
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0236 0.1024
Echinococcus granulosus caspase 8 0.0044 0.0236 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0474 0.3536 0.3528
Treponema pallidum ribonuclease Z 0.0016 0.0014 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.2149 0.987
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0173 0.0317
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0092 0.0154
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0069
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0996 0.1962
Trichomonas vaginalis hypothetical protein 0.0018 0.0034 0.0093
Echinococcus multilocularis dna polymerase eta 0.002 0.0047 0.0036
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0007
Onchocerca volvulus Putative hydrolase PNKD 0.0016 0.0014 0.0004
Schistosoma mansoni hypothetical protein 0.0706 0.5318 0.5312
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0018 0.0338
Echinococcus multilocularis ETS transcription factor Elf 2 0.0022 0.0068 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0399 0.0768
Echinococcus granulosus ferritin 0.0026 0.0092 0.008
Schistosoma mansoni ferritin 0.0026 0.0092 0.008
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0149 0.1038 0.4747
Echinococcus multilocularis dna polymerase kappa 0.002 0.0047 0.0036
Echinococcus multilocularis sentrin specific protease 8 0.0065 0.0394 0.0383
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0007
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0213 0.0202
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.007 0.0433 0.1942
Schistosoma mansoni importin beta-1 0.0029 0.0119 0.0108
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0117 0.0797 0.0787
Onchocerca volvulus 0.0036 0.0173 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0398 0.0387
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0219 0.1575 0.1566
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0149 0.0648
Mycobacterium ulcerans hypothetical protein 0.0036 0.0173 0.0317
Entamoeba histolytica serine/threonine protein kinase, putative 0.0297 0.2177 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0012 0.0001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.006
Brugia malayi Fli-1 protein 0.0471 0.3511 0.4268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0255 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Schistosoma mansoni ran 0.0021 0.006 0.0049
Loa Loa (eye worm) hypothetical protein 0.003 0.0126 0.014
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0003
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0001
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0014 0.001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0155 0.0144
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0016 0.0014 0.001
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0092 0.0154
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0014 0.0004
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0413 0.3067 0.6098
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0016 0.0014 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Echinococcus multilocularis smad 0.0034 0.0155 0.0144
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.018 0.0169
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0213 0.0202
Echinococcus granulosus GA binding protein alpha chain 0.0155 0.1086 0.1076
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0297 0.2177 0.2168
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0154 0.1076 0.4914
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0014 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0119 0.0108
Brugia malayi MH1 domain containing protein 0.0034 0.0155 0.0175
Brugia malayi Muscleblind-like protein 0.1082 0.8212 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0398 0.0387
Entamoeba histolytica Ran family GTPase 0.0021 0.006 0.0238
Loa Loa (eye worm) hypothetical protein 0.1082 0.8212 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0176 0.0749
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0047 0.0044
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0236 0.1115
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0155 0.0175
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0072 0.0061
Mycobacterium ulcerans lipoprotein LpqF 0.0198 0.1418 0.2803
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Schistosoma mansoni apoferritin-2 0.0026 0.0092 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Entamoeba histolytica hypothetical protein 0.0037 0.0176 0.0773
Mycobacterium tuberculosis Conserved protein 0.0036 0.0173 0.0317
Loa Loa (eye worm) transcription factor SMAD2 0.0496 0.3708 0.4507
Echinococcus granulosus caspase 2 0.0086 0.0554 0.0543
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0047 0.0162
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0014 0.0027
Echinococcus multilocularis cpg binding protein 0.0162 0.1138 0.1128
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0667 0.502 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0236 0.1026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Brugia malayi MH1 domain containing protein 0.0034 0.0155 0.0175
Schistosoma mansoni hypothetical protein 0.0023 0.0072 0.0061
Echinococcus granulosus phd:f box containing protein 0.0015 0.0012 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.0005
Brugia malayi hypothetical protein 0.0016 0.0014 0.0004
Schistosoma mansoni myst-related protein 0.0022 0.0063 0.0052
Schistosoma mansoni ferritin 0.0026 0.0092 0.008
Schistosoma mansoni hypothetical protein 0.0706 0.5318 0.5312
Brugia malayi CXXC zinc finger family protein 0.0149 0.104 0.1255
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0018 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0173 0.0162
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0016 0.0014 0.0004
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0065 0.0394 0.0383
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0012 0.0001
Schistosoma mansoni smad1 5 8 and 0.0034 0.0155 0.0144
Leishmania major DNA polymerase kappa, putative 0.002 0.0047 0.0162
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0173 0.0317
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0255 0.0244
Echinococcus multilocularis muscleblind protein 1 0.1082 0.8212 0.821
Schistosoma mansoni glutaminase 0.0274 0.2003 0.1994
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0155 0.0649
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0003
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0077 0.029
Schistosoma mansoni DNA helicase recq5 0.003 0.0126 0.0115
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0117 0.0797 0.0787
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0092 0.0368
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0236 0.0274
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0173 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0176 0.0758
Schistosoma mansoni eyes absent homolog 0.0089 0.058 0.057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0173 0.0317
Echinococcus granulosus expressed protein 0.0026 0.0092 0.008
Schistosoma mansoni ets-related 0.0022 0.0068 0.0057
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.006
Brugia malayi hypothetical protein 0.0089 0.058 0.0694
Loa Loa (eye worm) ets-domain-containing protein 0.0022 0.0068 0.0069
Brugia malayi MH2 domain containing protein 0.0034 0.0155 0.0175
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0297 0.2177 0.2641
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Onchocerca volvulus 0.0149 0.104 0.1422
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0012 0.0001
Echinococcus granulosus snurportin 1 0.0311 0.2288 0.2279
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1669 0.3306
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Mycobacterium ulcerans lipase LipD 0.0036 0.0173 0.0317
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0432 0.0421
Echinococcus granulosus ubiquitin specific protease 41 0.0154 0.1076 0.1066
Plasmodium vivax metacaspase 1, putative 0.0044 0.0236 0.8106
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.029 1
Echinococcus multilocularis GA binding protein alpha chain 0.0155 0.1086 0.1076
Onchocerca volvulus Cell death protein 3 homolog 0.0086 0.0554 0.075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0155 0.0649
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1657 0.1648
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1025 0.4672
Onchocerca volvulus 0.0016 0.0019 0.001
Loa Loa (eye worm) PHD-finger family protein 0.0046 0.0252 0.0293
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.6199 0.6195
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0809
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0176 0.0749
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0236 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Brugia malayi MH2 domain containing protein 0.0496 0.3708 0.4507
Trichomonas vaginalis glutaminase, putative 0.0274 0.2003 0.9196
Echinococcus granulosus ETS transcription factor Elf 2 0.0022 0.0068 0.0057
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0014 0.0003
Trypanosoma cruzi metacaspase, putative 0.0044 0.0236 0.1036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0034 0.0093
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0154 0.1076 0.4914
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0014 0.0027
Brugia malayi Ets-domain containing protein 0.0155 0.1086 0.1311
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0028
Loa Loa (eye worm) glutaminase 2 0.0274 0.2003 0.2429
Brugia malayi Cell death protein 3 precursor 0.0086 0.0554 0.0662
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0012 0.0049
Brugia malayi MH1 domain containing protein 0.0019 0.0039 0.0034
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0255 0.0297
Leishmania major DNA polymerase eta, putative 0.002 0.0047 0.0162
Brugia malayi N-terminal motif family protein 0.0183 0.1299 0.157
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0487 0.0476
Trypanosoma cruzi metacaspase, putative 0.0044 0.0236 0.1036
Echinococcus multilocularis caspase 0.0117 0.0797 0.0787
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0487 0.0476
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0013 0.0054
Echinococcus multilocularis protein C ets 2 0.0022 0.0068 0.0057
Trypanosoma brucei ISWI complex protein 0.0016 0.0015 0.0071
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0398 0.0471
Brugia malayi TAR-binding protein 0.0065 0.0398 0.0471
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.2149 1
Schistosoma mansoni hypothetical protein 0.0311 0.2288 0.2279
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0018 0.0008
Echinococcus granulosus sentrin specific protease 8 0.0065 0.0394 0.0383
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.029 1
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0996 0.1962
Loa Loa (eye worm) RecQ helicase 0.0044 0.0236 0.0274
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0149 0.0632
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0176 0.0758
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0333 0.0322
Loa Loa (eye worm) hypothetical protein 0.0089 0.058 0.0694
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0081 0.0517 0.0506
Echinococcus granulosus ETS transcription factor Elf 5 0.0022 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0159 0.1118 0.135
Trichomonas vaginalis ferritin, putative 0.0026 0.0092 0.0357
Schistosoma mansoni hypothetical protein 0.0077 0.0487 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0236 0.1026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0316 0.2324 0.2315
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0394 0.1757
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0059 0.035 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0236 0.1026
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0018 0.0078
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.1734
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0154 0.1076 0.4909
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0213 0.7249
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0173 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.1076 0.4909
Loa Loa (eye worm) hypothetical protein 0.0366 0.2705 0.3285
Schistosoma mansoni tsg101-related 0.0182 0.1294 0.1284
Brugia malayi hypothetical protein 0.0229 0.1657 0.2007
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.526 0.5254
Brugia malayi hypothetical protein 0.0957 0.7245 0.8821
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0014 0.0027
Schistosoma mansoni hypothetical protein 0.0203 0.1453 0.1443
Echinococcus granulosus smad 0.0034 0.0155 0.0144
Echinococcus multilocularis caspase 2 0.0086 0.0554 0.0543
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0162
Brugia malayi glutaminase DH11.1 0.0274 0.2003 0.2429
Loa Loa (eye worm) MH2 domain-containing protein 0.0496 0.3708 0.4507
Plasmodium vivax importin-beta 2, putative 0.0029 0.0119 0.3944
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0047 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.029 0.133
Schistosoma mansoni cpg binding protein 0.0162 0.1138 0.1128
Trypanosoma brucei metacaspase MCA3 0.0044 0.0236 0.1086
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0044 0.0236 0.0274
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0012 0.0001
Brugia malayi PHD-finger family protein 0.0065 0.0391 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0173 0.0743
Schistosoma mansoni cpg binding protein 0.0149 0.104 0.103
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0173 0.0317
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0197
Entamoeba histolytica hypothetical protein 0.0077 0.0487 0.2206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0126 0.0115
Toxoplasma gondii histone lysine methyltransferase SET1 0.0288 0.2105 1
Echinococcus multilocularis dnaJ subfamily B 0.1315 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.0222
Loa Loa (eye worm) beta-lactamase 0.0036 0.0173 0.0197
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0012 0.0049
Echinococcus granulosus dna polymerase eta 0.002 0.0047 0.0036
Echinococcus granulosus ETS transcription factor Elf 1 0.0022 0.0068 0.0057
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.2177 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0022 0.0068 0.0069
Trypanosoma cruzi glyoxalase II 0.0016 0.0014 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0255 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0398 0.0387
Loa Loa (eye worm) hypothetical protein 0.1082 0.8212 1
Echinococcus multilocularis ferritin 0.0026 0.0092 0.008
Trypanosoma cruzi metacaspase, putative 0.0044 0.0236 0.1036
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.3536 0.3528
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0014 0.0003
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0014 0.001
Loa Loa (eye worm) Ulp1 protease 0.0065 0.0394 0.0467
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.006 0.0278
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0154 0.1076 0.1066
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0016 0.0014 0.006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0155 0.0144
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0432 0.0421
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.011 0.0099
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0333 0.0322
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0014 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0046 0.0249 0.0238
Trichomonas vaginalis esterase, putative 0.0036 0.0173 0.0733
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0173 0.0733
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0162
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Leishmania major metallo-beta-lactamase family-like protein 0.0016 0.0014 0.001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0004
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0014 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0173 0.0743
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0046 0.0249 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0236 0.1026
Schistosoma mansoni hypothetical protein 0.0022 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0077 0.03
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0001
Plasmodium falciparum zinc finger protein, putative 0.0022 0.0063 0.1847
Echinococcus multilocularis ets variant gene 4 0.0022 0.0068 0.0057
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0014 0.0003
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0022 0.0068 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0217
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0399 0.0768
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Echinococcus granulosus protein C ets 2 0.0022 0.0068 0.0057
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0072 0.0061
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0394 0.1757
Schistosoma mansoni bromodomain containing protein 0.0018 0.0034 0.0023
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0173 0.0162
Brugia malayi beta-lactamase family protein 0.0036 0.0173 0.0197
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0018 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0077 0.029
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0047 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0173 0.0733
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Schistosoma mansoni cpg binding protein 0.0162 0.1138 0.1128
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0219 0.1575 0.1566
Brugia malayi hypothetical protein 0.0219 0.1575 0.1907
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0154 0.1076 0.1066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0132
Brugia malayi Importin beta-1 subunit 0.0029 0.0119 0.0132
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0065 0.0394 0.1779
Brugia malayi MH1 domain containing protein 0.0019 0.0039 0.0034
Leishmania major GTP-binding protein, putative 0.0021 0.006 0.0222
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.2288 0.2776
Schistosoma mansoni hypothetical protein 0.0041 0.0213 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Schistosoma mansoni ets-related 0.0471 0.3511 0.3504
Leishmania major hypothetical protein, conserved 0.0016 0.0014 0.001
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0014 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0155 0.0649
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0018 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Brugia malayi Ets-domain containing protein 0.0022 0.0068 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0155 0.0649
Echinococcus granulosus tar DNA binding protein 0.0065 0.0398 0.0387
Echinococcus multilocularis geminin 0.0706 0.5318 0.5312
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0081 0.0517 0.0506
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0398 0.0387
Leishmania major hypothetical protein, conserved 0.0051 0.029 0.1282
Trypanosoma brucei Metacaspase-4 0.0044 0.0236 0.1086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0155 0.0649
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.0118 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2149 0.987
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0047 0.0044
Schistosoma mansoni hypothetical protein 0.1315 1 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0014 0.0027
Onchocerca volvulus 0.0036 0.0173 0.0223
Onchocerca volvulus Serine\/threonine kinase homolog 0.0297 0.2177 0.2994
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0154 0.1076 0.1298
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.1299 0.1779
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0022 0.0068 0.0057
Brugia malayi isocitrate dehydrogenase 0.0016 0.0018 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0047 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0236 0.1026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0215 0.0204
Mycobacterium ulcerans beta-lactamase 0.0036 0.0173 0.0317
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0037 0.0176 0.0758
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.526 0.5254
Echinococcus granulosus cpg binding protein 0.0162 0.1138 0.1128
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0119 0.0548
Onchocerca volvulus 0.0047 0.0255 0.0336
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0014 0.001
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0012 0.0001
Echinococcus granulosus geminin 0.0706 0.5318 0.5312
Schistosoma mansoni smad1 5 8 and 0.0034 0.0155 0.0144
Leishmania major importin beta-1 subunit, putative 0.0024 0.0077 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2177 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.029 0.1282

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.