Detailed information for compound 826718

Basic information

Technical information
  • TDR Targets ID: 826718
  • Name: 6-chloro-2-[(4-fluorophenyl)methylsulfanyl]-1 H-benzimidazole
  • MW: 292.759 | Formula: C14H10ClFN2S
  • H donors: 1 H acceptors: 1 LogP: 4.38 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CSc1nc2c([nH]1)ccc(c2)Cl
  • InChi: 1S/C14H10ClFN2S/c15-10-3-6-12-13(7-10)18-14(17-12)19-8-9-1-4-11(16)5-2-9/h1-7H,8H2,(H,17,18)
  • InChiKey: CMBIFMJYKAVYEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-2-[(4-fluorophenyl)methylthio]-1H-benzimidazole
  • 6-chloro-2-[(4-fluorobenzyl)thio]-1H-benzimidazole
  • T5477233

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum tubulin epsilon chain, putative 0.0057 0.0047 0.0262
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0121 0.0152 0.0218
Plasmodium vivax tubulin alpha chain, putative 0.0066 0.0061 0.0138
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0121 0.0152 0.0218
Trypanosoma brucei beta tubulin 0.0108 0.0131 0.0423
Echinococcus granulosus Immunoglobulin 0.0242 0.0353 0.0505
Schistosoma mansoni cell adhesion molecule 0.0052 0.0038 0.0038
Echinococcus granulosus tubulin alpha 3 chain 0.0066 0.0061 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0667 0.1061 0.354
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0001 0.0002
Brugia malayi Peroxidasin 0.0052 0.0038 0.0128
Entamoeba histolytica protein kinase , putative 0.0667 0.1061 0.3509
Echinococcus multilocularis Tubulin beta 2C chain 0.0108 0.0131 0.0188
Trypanosoma brucei beta tubulin 0.0108 0.0131 0.0423
Trichomonas vaginalis tubulin epsilon chain, putative 0.0108 0.0131 0.0423
Echinococcus multilocularis Tubulin alpha 1 chain 0.0066 0.0061 0.0087
Entamoeba histolytica tubulin alpha-1 chain 0.0066 0.0061 0.0139
Echinococcus granulosus Down syndrome cell adhesion molecule 0.003 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1826 0.2987 0.4271
Schistosoma mansoni titin 0.0046 0.0028 0.0028
Schistosoma mansoni tubulin subunit alpha 0.0066 0.0061 0.0061
Loa Loa (eye worm) tubulin alpha chain 0.0066 0.0061 0.0203
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0283 0.0422 0.5584
Echinococcus granulosus tubulin beta 4A class IVa 0.0108 0.0131 0.0188
Brugia malayi Immunoglobulin I-set domain containing protein 0.1487 0.2423 0.8114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.002 0.0066
Echinococcus granulosus tubulin epsilon chain 0.0057 0.0047 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0283 0.0422 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0066 0.0061 0.0087
Echinococcus granulosus Tubulin alpha 1 chain 0.0066 0.0061 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0127
Loa Loa (eye worm) BEN-1 protein 0.0108 0.0131 0.044
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0052 0.0038 0.0127
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Echinococcus multilocularis survival motor neuron protein 1 0.0198 0.028 0.0401
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Echinococcus multilocularis peroxidasin 0.0052 0.0038 0.0055
Echinococcus multilocularis tubulin gamma 1 chain 0.0057 0.0047 0.0067
Plasmodium vivax tubulin alpha chain, putative 0.0066 0.0061 0.0138
Brugia malayi serine/threonine-protein kinase plk-2 0.1826 0.2987 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0108 0.0131 0.0188
Schistosoma mansoni tubulin subunit beta 0.0108 0.0131 0.0131
Echinococcus multilocularis beta tubulin 0.0108 0.0131 0.0188
Loa Loa (eye worm) tubulin alpha 2 0.0041 0.0019 0.0064
Echinococcus granulosus neuroglian 0.0056 0.0044 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0036 0.0036
Giardia lamblia Alpha-tubulin 0.0066 0.0061 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Echinococcus multilocularis tubulin alpha 1C chain 0.0066 0.0061 0.0087
Schistosoma mansoni protein kinase 0.0041 0.0019 0.0019
Brugia malayi Tubulin alpha-2 chain 0.0066 0.0061 0.0203
Schistosoma mansoni tyrosine kinase 0.0076 0.0078 0.0078
Echinococcus multilocularis roundabout 2 0.0056 0.0044 0.0062
Echinococcus multilocularis Tubulin beta 2C chain 0.0108 0.0131 0.0188
Brugia malayi Cytochrome P450 family protein 0.0283 0.0422 0.1413
Trypanosoma brucei alpha tubulin 0.0066 0.0061 0.0186
Trichomonas vaginalis set domain proteins, putative 0.0198 0.0281 0.0924
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0283 0.0422 0.5584
Trypanosoma brucei tubulin gamma chain 0.0057 0.0047 0.0139
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0283 0.0422 1
Echinococcus granulosus lachesin 0.0052 0.0038 0.0054
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0041 0.0019 0.0028
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0283 0.0422 0.5584
Trypanosoma cruzi polo-like protein kinase, putative 0.1826 0.2987 1
Entamoeba histolytica protein kinase, putative 0.0667 0.1061 0.3509
Giardia lamblia Aurora kinase 0.0667 0.1061 0.3449
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Trypanosoma brucei protein kinase, putative 0.0041 0.0019 0.0048
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1487 0.2423 0.8114
Schistosoma mansoni cytochrome P450 0.0283 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0198 0.028 0.0938
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0056 0.0044 0.0062
Loa Loa (eye worm) tubulin alpha 2 0.0041 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0245 0.0359 0.1202
Echinococcus multilocularis tubulin alpha chain 0.0066 0.0061 0.0087
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.4236 0.6993 1
Loa Loa (eye worm) AUR protein kinase 0.0667 0.1061 0.3551
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Brugia malayi Prion-like- 0.0052 0.0038 0.0127
Loa Loa (eye worm) hypothetical protein 0.0066 0.0061 0.0203
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0038 0.0127
Brugia malayi Tubulin alpha-2 chain 0.0066 0.0061 0.0203
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.004 0.0018 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0283 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.0397 0.1328
Brugia malayi hypothetical protein 0.0245 0.0359 0.1202
Onchocerca volvulus 0.0198 0.0281 0.094
Echinococcus granulosus Tubulin beta 2C chain 0.0108 0.0131 0.0188
Trypanosoma brucei cytochrome P450, putative 0.0467 0.0728 0.2423
Trypanosoma cruzi alpha tubulin, putative 0.0066 0.0061 0.0139
Brugia malayi hypothetical protein 0.0198 0.028 0.0938
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0108 0.0131 0.0188
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0283 0.0422 1
Trypanosoma brucei alpha tubulin 0.0066 0.0061 0.0186
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0041 0.0019 0.0048
Echinococcus multilocularis tubulin alpha 3 chain 0.0066 0.0061 0.0087
Loa Loa (eye worm) tubulin beta-2A chain 0.0108 0.0131 0.044
Echinococcus granulosus cytochrome P450 2K1 0.0283 0.0422 0.0604
Trypanosoma brucei aurora B kinase 0.0667 0.1061 0.354
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0041 0.0019 0.0064
Schistosoma mansoni cell adhesion molecule 0.0272 0.0403 0.0403
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0283 0.0422 0.1357
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0128
Loa Loa (eye worm) AUR protein kinase 0.0667 0.1061 0.3551
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Echinococcus granulosus Tubulin beta 2C chain 0.0108 0.0131 0.0188
Trypanosoma brucei beta tubulin 0.0057 0.0047 0.0139
Trichomonas vaginalis tubulin beta chain, putative 0.0108 0.0131 0.0423
Echinococcus multilocularis titin 0.0046 0.0028 0.004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0084 0.0091 0.0799
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0283 0.0422 0.5584
Trypanosoma brucei epsilon tubulin 0.0057 0.0047 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0283 0.0422 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0667 0.1061 0.3509
Trypanosoma brucei alpha tubulin 0.0066 0.0061 0.0186
Echinococcus granulosus tubulin subunit TubB 0.0066 0.0061 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0667 0.1061 0.1061
Trichomonas vaginalis tubulin, putative 0.0108 0.0131 0.0423
Plasmodium falciparum tubulin beta chain 0.0108 0.0131 0.1075
Trypanosoma brucei epsilon tubulin 0.0057 0.0047 0.0139
Entamoeba histolytica tubulin family protein 0.0108 0.0131 0.0377
Loa Loa (eye worm) alpha-tubulin 0.0066 0.0061 0.0203
Echinococcus granulosus fibroblast growth factor receptor 4 0.0121 0.0152 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0667 0.1061 0.354
Plasmodium falciparum alpha tubulin 2 0.0066 0.0061 0.0397
Echinococcus granulosus tubulin gamma 1 chain 0.0057 0.0047 0.0067
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0034 0.0114
Echinococcus granulosus roundabout 2 0.0056 0.0044 0.0062
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0061 0.0186
Entamoeba histolytica tubulin alpha chain, putative 0.0066 0.0061 0.0139
Echinococcus granulosus tyrosine protein kinase Lyn 0.0041 0.0019 0.0028
Echinococcus granulosus tubulin alpha 0.0057 0.0047 0.0067
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0036 0.0156
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0061 0.0186
Echinococcus multilocularis neuroglian 0.0056 0.0044 0.0062
Echinococcus multilocularis neuroglian 0.0268 0.0396 0.0566
Onchocerca volvulus 0.0046 0.0028 0.0095
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0001 0.0002
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0667 0.1061 0.1517
Loa Loa (eye worm) TK protein kinase 0.0147 0.0195 0.0653
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.4236 0.6993 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0242 0.0353 0.0353
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.002 0.0066
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.003 0.0001 0.0001
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Schistosoma mansoni neuroglian 0.0056 0.0044 0.0044
Brugia malayi serine/threonine kinase 12 0.0667 0.1061 0.3551
Echinococcus multilocularis Immunoglobulin 0.0242 0.0353 0.0505
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0127
Trypanosoma cruzi tubulin gamma chain 0.0057 0.0047 0.0092
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0036 0.0055
Echinococcus multilocularis lachesin 0.0052 0.0038 0.0054
Schistosoma mansoni titin 0.0052 0.0038 0.0038
Trypanosoma brucei beta tubulin 0.0108 0.0131 0.0423
Loa Loa (eye worm) tubulin gamma chain 0.0057 0.0047 0.0157
Entamoeba histolytica protein kinase domain containing protein 0.0667 0.1061 0.3509
Brugia malayi Tubulin gamma chain 0.0057 0.0047 0.0157
Toxoplasma gondii beta tubulin 0.0108 0.0131 0.1075
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Schistosoma mansoni vesicular amine transporter 0.0242 0.0353 0.0353
Echinococcus multilocularis tubulin epsilon chain 0.0057 0.0047 0.0067
Brugia malayi Cytochrome P450 family protein 0.0467 0.0728 0.2437
Brugia malayi Cytochrome P450 family protein 0.1084 0.1753 0.5871
Echinococcus multilocularis beta tubulin 0.0108 0.0131 0.0188
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1826 0.2987 0.4271
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0283 0.0422 0.5584
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0038 0.0127
Trypanosoma cruzi cytochrome P450, putative 0.0467 0.0728 0.2387
Loa Loa (eye worm) cytochrome P450 0.0283 0.0422 0.1413
Echinococcus multilocularis Immunoglobulin 0.0242 0.0353 0.0505
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0283 0.0422 0.5584
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0283 0.0422 0.1357
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.005 0.0034 0.0049
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0038 0.0127
Toxoplasma gondii alpha-tubulin I, putative 0.0066 0.0061 0.0397
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0283 0.0422 0.5584
Brugia malayi Pre-SET motif family protein 0.0174 0.0241 0.0806
Echinococcus granulosus aurora kinase A 0.0667 0.1061 0.1517
Brugia malayi Tubulin beta-1 chain 0.0108 0.0131 0.044
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0172 0.0237 0.0734
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0242 0.0353 0.0505
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0667 0.1061 0.1517
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Schistosoma mansoni protein kinase 0.0041 0.0019 0.0019
Echinococcus multilocularis peroxisome assembly protein 26 0.0066 0.0061 0.0087
Loa Loa (eye worm) hypothetical protein 0.0242 0.0353 0.1182
Mycobacterium leprae Conserved hypothetical protein 0.0283 0.0422 1
Leishmania major gamma-tubulin 0.0057 0.0047 0.0092
Echinococcus granulosus Tubulin beta 2C chain 0.0108 0.0131 0.0188
Giardia lamblia Fructose-bisphosphate aldolase 0.0172 0.0237 0.0648
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0283 0.0422 0.5584
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0047 0.0139
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0667 0.1061 0.3509
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0667 0.1061 0.3509
Loa Loa (eye worm) hypothetical protein 0.0184 0.0257 0.086
Schistosoma mansoni nephrin 0.0271 0.0402 0.0402
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0283 0.0422 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0283 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.044 0.1472
Plasmodium falciparum alpha tubulin 1 0.0066 0.0061 0.0397
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0056 0.0044 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0057 0.0047 0.0262
Toxoplasma gondii aurora kinase 0.0667 0.1061 1
Echinococcus granulosus tubulin alpha 3 chain 0.0066 0.0061 0.0087
Echinococcus multilocularis 0.0283 0.0422 0.0604
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0056 0.0044 0.0062
Giardia lamblia Beta tubulin 0.0108 0.0131 0.0288
Echinococcus granulosus peroxidasin 0.0052 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0127
Echinococcus multilocularis hemicentin 1 0.0052 0.0038 0.0054
Plasmodium vivax tubulin beta chain, putative 0.0108 0.0131 0.0835
Treponema pallidum ATP-binding protein (ylxH-1) 0.0314 0.0473 1
Schistosoma mansoni tubulin subunit beta 0.0108 0.0131 0.0131
Schistosoma mansoni tubulin subunit gamma 0.0057 0.0047 0.0047
Echinococcus granulosus beta tubulin 0.0108 0.0131 0.0188
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0084 0.0091 0.1432
Echinococcus granulosus twitchin 0.0285 0.0424 0.0607
Entamoeba histolytica protein kinase, putative 0.0667 0.1061 0.3509
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0073 0.0072 0.0241
Toxoplasma gondii alpha tubulin TUBA1 0.0066 0.0061 0.0397
Echinococcus granulosus tubulin alpha chain 0.0066 0.0061 0.0087
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0036 0.0051
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0283 0.0422 0.5584
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0041 0.0019 0.0047
Loa Loa (eye worm) tubulin alpha-3 chain 0.0033 0.0007 0.0022
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0667 0.1061 1
Schistosoma mansoni cell adhesion molecule 0.0056 0.0044 0.0044
Brugia malayi beta-tubulin, identical 0.0108 0.0131 0.044
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0283 0.0422 0.5584
Echinococcus multilocularis tyrosine protein kinase otk 0.0052 0.0038 0.0054
Brugia malayi Cytochrome P450 family protein 0.0467 0.0728 0.2437
Echinococcus multilocularis tubulin alpha chain 0.0066 0.0061 0.0087
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Schistosoma mansoni tubulin subunit beta 0.0108 0.0131 0.0131
Plasmodium falciparum tubulin gamma chain 0.0057 0.0047 0.0262
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.0007 0.0005
Giardia lamblia Kinase, PLK 0.1826 0.2987 1
Echinococcus granulosus tubulin alpha chain 0.0066 0.0061 0.0087
Loa Loa (eye worm) tubulin beta-4 chain 0.0108 0.0131 0.044
Loa Loa (eye worm) hypothetical protein 0.0294 0.044 0.1472
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0283 0.0422 0.5584
Loa Loa (eye worm) hypothetical protein 0.0245 0.0359 0.1202
Leishmania major cytochrome p450-like protein 0.0467 0.0728 0.2387
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Echinococcus granulosus alpha tubulin 0.0066 0.0061 0.0087
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0061 0.0186
Echinococcus multilocularis hypothetical protein 0.0066 0.0061 0.0087
Giardia lamblia Beta tubulin 0.0108 0.0131 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0044 0.0146
Echinococcus granulosus tubulin beta 1 chain 0.0108 0.0131 0.0188
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0036 0.0051
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.1568
Trichomonas vaginalis tubulin alpha chain, putative 0.0057 0.0047 0.0139
Trichomonas vaginalis tubulin gamma chain, putative 0.0108 0.0131 0.0423
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Entamoeba histolytica tubulin family protein 0.0108 0.0131 0.0377
Schistosoma mansoni cell adhesion molecule 0.0056 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0667 0.1061 0.354
Loa Loa (eye worm) hypothetical protein 0.0033 0.0007 0.0022
Echinococcus granulosus defective proboscis extension response 0.0242 0.0353 0.0505
Loa Loa (eye worm) hypothetical protein 0.0242 0.0353 0.1182
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0172 0.0237 0.0734
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0052 0.0038 0.0038
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0061 0.0186
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0036 0.0036
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0056 0.0044 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0283 0.0422 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1826 0.2987 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0467 0.0728 0.2437
Loa Loa (eye worm) CYP4Cod1 0.0467 0.0728 0.2437
Loa Loa (eye worm) CAMK protein kinase 0.0046 0.0028 0.0095
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0056 0.0044 0.0062
Echinococcus multilocularis roundabout 2 0.0056 0.0044 0.0062
Echinococcus granulosus activin receptor type 0.0041 0.0019 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0283 0.0422 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0283 0.0422 1
Echinococcus granulosus hemicentin 1 0.0052 0.0038 0.0054
Echinococcus granulosus survival motor neuron protein 1 0.0198 0.028 0.0401
Leishmania major epsilon tubulin, putative 0.0057 0.0047 0.0092
Trypanosoma cruzi polo-like protein kinase, putative 0.1826 0.2987 1
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0467 0.0728 1
Schistosoma mansoni tubulin subunit beta 0.0108 0.0131 0.0131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0147 0.0195 0.0653
Onchocerca volvulus 0.0033 0.0005 0.0018
Echinococcus multilocularis tubulin alpha chain 0.0066 0.0061 0.0087
Echinococcus multilocularis tubulin alpha chain 0.0066 0.0061 0.0087
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0041 0.0019 0.0028
Loa Loa (eye worm) AUR protein kinase 0.0667 0.1061 0.3551
Echinococcus granulosus Tubulin alpha 1 chain 0.0066 0.0061 0.0087
Brugia malayi hypothetical protein 0.0311 0.0468 0.1568
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0283 0.0422 1
Onchocerca volvulus Tyrosine kinase homolog 0.1245 0.2021 0.6766
Schistosoma mansoni tubulin subunit alpha 0.0066 0.0061 0.0061
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0283 0.0422 1
Schistosoma mansoni nephrin 0.0056 0.0044 0.0044
Schistosoma mansoni septate junction protein 0.0052 0.0038 0.0038
Echinococcus granulosus neuroglian 0.0268 0.0396 0.0566
Echinococcus multilocularis activin receptor type 0.0041 0.0019 0.0028
Schistosoma mansoni tubulin subunit beta 0.0108 0.0131 0.0131
Echinococcus granulosus roundabout 2 0.0056 0.0044 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0283 0.0422 1
Echinococcus granulosus tubulin alpha chain 0.0066 0.0061 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0121 0.0152 0.0218
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0174 0.0241 0.0806
Echinococcus multilocularis roundabout 2 0.0297 0.0446 0.0637
Mycobacterium leprae putative cytochrome p450 0.0283 0.0422 1
Leishmania major cytochrome p450-like protein 0.0283 0.0422 0.1357
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0038 0.0127
Echinococcus multilocularis twitchin 0.0043 0.0022 0.0032
Echinococcus granulosus Tubulin beta 2C chain 0.0108 0.0131 0.0188
Onchocerca volvulus Serine\/threonine kinase homolog 0.1826 0.2987 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0283 0.0422 1
Echinococcus multilocularis hemicentin 1 0.0052 0.0038 0.0054
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0283 0.0422 0.5584
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0283 0.0422 0.5584
Brugia malayi alpha-tubulin 0.0066 0.0061 0.0203
Schistosoma mansoni septate junction protein 0.0052 0.0038 0.0038
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0044 0.0146
Loa Loa (eye worm) tubulin beta-1 chain 0.0108 0.0131 0.044
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0061 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Echinococcus granulosus beta tubulin 0.0108 0.0131 0.0188
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0283 0.0422 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0467 0.0728 0.2437
Loa Loa (eye worm) beta-tubulin 0.0108 0.0131 0.044
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0283 0.0422 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0283 0.0422 1
Echinococcus granulosus tubulin subunit beta 0.0108 0.0131 0.0188
Onchocerca volvulus 0.004 0.0018 0.0061
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.005 0.0034 0.0049
Echinococcus granulosus tubulin alpha 1C chain 0.0066 0.0061 0.0087
Loa Loa (eye worm) hypothetical protein 0.0056 0.0044 0.0146
Echinococcus granulosus contactin 0.0056 0.0044 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0022 0.0022
Echinococcus multilocularis tubulin subunit beta 0.0108 0.0131 0.0188
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Loa Loa (eye worm) BEN-1 protein 0.0108 0.0131 0.044
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0056 0.0044 0.0146
Echinococcus granulosus tubulin alpha chain 0.0066 0.0061 0.0087
Trypanosoma brucei alpha tubulin 0.0066 0.0061 0.0186
Brugia malayi Fibronectin type III domain containing protein 0.0245 0.0359 0.1202
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0283 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.0359 0.1202
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1826 0.2987 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0283 0.0422 0.5584
Echinococcus multilocularis Tubulin beta 2C chain 0.0108 0.0131 0.0188
Trichomonas vaginalis AGC family protein kinase 0.0667 0.1061 0.354
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0283 0.0422 1
Loa Loa (eye worm) cytochrome P450 family protein 0.1084 0.1753 0.5871
Onchocerca volvulus 0.1195 0.1938 0.6489
Echinococcus multilocularis Tubulin alpha 1 chain 0.0066 0.0061 0.0087
Entamoeba histolytica tubulin gamma chain 0.0057 0.0047 0.0092
Brugia malayi Tubulin beta chain 0.0033 0.0005 0.0018
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0283 0.0422 0.5584
Echinococcus multilocularis Tubulin alpha 1 chain 0.0066 0.0061 0.0087
Echinococcus granulosus peroxisome assembly protein 26 0.0066 0.0061 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0127
Toxoplasma gondii cytochrome p450 superfamily protein 0.0283 0.0422 0.3868
Echinococcus granulosus Tubulin beta 2C chain 0.0108 0.0131 0.0188
Schistosoma mansoni protein kinase 0.0041 0.0019 0.0019
Leishmania major protein kinase, putative 0.0667 0.1061 0.3509
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0061 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0044 0.0146
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0283 0.0422 0.5584
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0046 0.0028 0.0095
Echinococcus multilocularis aurora kinase A 0.0667 0.1061 0.1517
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0038 0.0127
Brugia malayi cytochrome P450 0.0283 0.0422 0.1413
Trichomonas vaginalis tubulin alpha chain, putative 0.0108 0.0131 0.0423
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0066 0.0061 0.0186
Echinococcus granulosus tubulin alpha chain 0.0066 0.0061 0.0087
Loa Loa (eye worm) tubulin beta chain 0.0108 0.0131 0.044
Toxoplasma gondii beta-tubulin, putative 0.0108 0.0131 0.1075
Echinococcus granulosus tyrosine protein kinase otk 0.0052 0.0038 0.0054
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0283 0.0422 0.5584
Schistosoma mansoni tubulin subunit beta 0.0108 0.0131 0.0131
Giardia lamblia Beta tubulin 0.0108 0.0131 0.0288
Echinococcus granulosus tubulin alpha 1C chain 0.0066 0.0061 0.0087
Brugia malayi Immunoglobulin I-set domain containing protein 0.0245 0.0359 0.1202
Echinococcus multilocularis tubulin alpha chain 0.0066 0.0061 0.0087
Brugia malayi tubulin alpha chain - mouse 0.0066 0.0061 0.0203
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0061 0.0186
Trypanosoma brucei beta tubulin 0.0108 0.0131 0.0423
Loa Loa (eye worm) hypothetical protein 0.0242 0.0353 0.1183
Echinococcus multilocularis tubulin beta 1 chain 0.0108 0.0131 0.0188
Trypanosoma cruzi beta tubulin, putative 0.0108 0.0131 0.0377
Brugia malayi tubulin alpha-2 chain 0.0066 0.0061 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.0127
Schistosoma mansoni tyrosine kinase 0.0121 0.0152 0.0152
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0047 0.0139
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0268 0.0397 0.0567
Trypanosoma cruzi epsilon tubulin, putative 0.0057 0.0047 0.0092
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0242 0.0353 0.0353
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0283 0.0422 0.1398
Schistosoma mansoni roundabout 0.0052 0.0038 0.0038
Brugia malayi serine/threonine-protein kinase 6 0.0667 0.1061 0.3551
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Trichomonas vaginalis tubulin epsilon chain, putative 0.0108 0.0131 0.0423
Leishmania major cytochrome p450-like protein 0.0283 0.0422 0.1357
Trypanosoma brucei polo-like protein kinase 0.1826 0.2987 1
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0061 0.0186
Schistosoma mansoni survival motor neuron protein 0.004 0.0018 0.0018
Toxoplasma gondii beta-1 tubulin, putative 0.0108 0.0131 0.1075
Echinococcus granulosus roundabout 2 0.0297 0.0446 0.0637
Brugia malayi serine/threonine protein kinase 6 0.0667 0.1061 0.3551
Loa Loa (eye worm) alpha-tubulin 0.0066 0.0061 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.1826 0.2987 0.2987
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0056 0.0044 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.1826 0.2987 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.0237 0.0778
Brugia malayi Tubulin alpha chain 0.0066 0.0061 0.0203
Echinococcus granulosus titin 0.0046 0.0028 0.004
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0283 0.0422 0.5584
Echinococcus multilocularis tubulin alpha 1C chain 0.0066 0.0061 0.0087
Schistosoma mansoni protein kinase 0.0667 0.1061 0.1061
Echinococcus multilocularis tubulin subunit TubB 0.0066 0.0061 0.0087
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0052 0.0038 0.0054
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0038 0.0127
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0028 0.0095
Trypanosoma brucei epsilon tubulin 0.0057 0.0047 0.0139
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0283 0.0422 0.5584
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Schistosoma mansoni tubulin subunit epsilon 0.0057 0.0047 0.0047
Loa Loa (eye worm) tubulin alpha-2 chain 0.0066 0.0061 0.0203
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0028 0.0028
Echinococcus granulosus Tubulin alpha 1 chain 0.0066 0.0061 0.0087
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0283 0.0422 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0283 0.0422 0.5584
Plasmodium falciparum serine/threonine protein kinase, putative 0.0667 0.1061 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0283 0.0422 0.1357
Trypanosoma cruzi aurora B kinase, putative 0.0667 0.1061 0.3509
Schistosoma mansoni hypothetical protein 0.0283 0.0422 0.0422
Leishmania major beta tubulin 0.0108 0.0131 0.0377
Schistosoma mansoni alpha tubulin 0.0066 0.0061 0.0061
Trypanosoma cruzi cytochrome P450, putative 0.0467 0.0728 0.2387
Loa Loa (eye worm) tubulin alpha chain 0.0066 0.0061 0.0203
Schistosoma mansoni hypothetical protein 0.004 0.0018 0.0018
Echinococcus granulosus titin 0.0046 0.0028 0.004
Leishmania major alpha tubulin 0.0066 0.0061 0.0139
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0283 0.0422 0.1357
Giardia lamblia Alpha-tubulin 0.0066 0.0061 0.0048
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0038 0.0127
Echinococcus multilocularis Tubulin beta 2C chain 0.0108 0.0131 0.0188
Schistosoma mansoni alpha tubulin 0.0066 0.0061 0.0061
Brugia malayi protein unc-22 0.0046 0.0028 0.0095
Schistosoma mansoni alpha tubulin 0.0066 0.0061 0.0061
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0038 0.0127
Schistosoma mansoni tubulin subunit alpha 0.0066 0.0061 0.0061
Entamoeba histolytica serine/threonine protein kinase, putative 0.1826 0.2987 1
Trypanosoma cruzi epsilon tubulin, putative 0.0057 0.0047 0.0092
Echinococcus multilocularis tubulin alpha 0.0057 0.0047 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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