Detailed information for compound 832866

Basic information

Technical information
  • TDR Targets ID: 832866
  • Name: N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]m ethyl]-N-prop-2-enylbenzenesulfonamide
  • MW: 369.437 | Formula: C19H19N3O3S
  • H donors: 0 H acceptors: 4 LogP: 3.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN(S(=O)(=O)c1ccccc1)Cc1onc(n1)c1cccc(c1)C
  • InChi: 1S/C19H19N3O3S/c1-3-12-22(26(23,24)17-10-5-4-6-11-17)14-18-20-19(21-25-18)16-9-7-8-15(2)13-16/h3-11,13H,1,12,14H2,2H3
  • InChiKey: CPBLUZXHKHVPFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-allyl-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
  • N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-prop-2-enyl-benzenesulfonamide
  • STK301180

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0528
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.0354
Brugia malayi ecdysteroid receptor 0.0204 0.2169 0.7561
Loa Loa (eye worm) hypothetical protein 0.0268 0.2868 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0769
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0055 0.0817
Schistosoma mansoni ap endonuclease 0.0021 0.0166 0.0304
Onchocerca volvulus 0.0106 0.1097 0.5042
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0347 1
Brugia malayi orphan nuclear receptor NR2E1 0.0096 0.0987 0.3442
Leishmania major pyruvate kinase 0.0038 0.0347 1
Brugia malayi hypothetical protein 0.0111 0.1153 0.402
Brugia malayi hypothetical protein 0.0096 0.0987 0.3442
Brugia malayi photoreceptor-specific nuclear receptor 0.0204 0.2169 0.7561
Onchocerca volvulus 0.0012 0.0061 0.025
Loa Loa (eye worm) DR-78 0.0096 0.0987 0.344
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0102 0.2802
Brugia malayi hypothetical protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Loa Loa (eye worm) patched family protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Loa Loa (eye worm) hypothetical protein 0.0048 0.0457 0.1591
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0166 0.4622
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni nuclear receptor 0.0096 0.0987 0.187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0227 0.6474
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.0354
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0204 0.2169 0.413
Echinococcus granulosus thyroid hormone receptor alpha 0.0096 0.0987 0.1879
Schistosoma mansoni hypothetical protein 0.0055 0.0531 0.1001
Brugia malayi follicle stimulating hormone receptor 0.0253 0.2708 0.944
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0054 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0055 0.1309
Giardia lamblia Pyruvate kinase 0.0019 0.0145 0.3095
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0096 0.0987 0.187
Echinococcus multilocularis pyruvate kinase 0.0019 0.0145 0.0144
Schistosoma mansoni topbp1 0.0011 0.0055 0.0092
Brugia malayi bZIP transcription factor family protein 0.0247 0.264 0.9205
Echinococcus granulosus nuclear factor of activated T cells 5 0.022 0.2349 0.4474
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.183
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0102 0.2538
Echinococcus multilocularis protein dispatched 1 0.0055 0.0531 0.053
Schistosoma mansoni nuclear hormone receptor 0.0096 0.0987 0.187
Brugia malayi hypothetical protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0528
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0243
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0061 0.0103
Schistosoma mansoni survival motor neuron protein 0.0055 0.0531 0.1001
Mycobacterium ulcerans carboxylesterase, LipT 0.0012 0.0061 0.1271
Brugia malayi nuclear hormone receptor family member nhr-6 0.0096 0.0987 0.3442
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Loa Loa (eye worm) hypothetical protein 0.0108 0.1114 0.3881
Onchocerca volvulus 0.0008 0.0019 0.0057
Loa Loa (eye worm) hypothetical protein 0.0059 0.0575 0.2002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0408 0.1421
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0102 0.2538
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0166 0.4687
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.1174 0.2226
Echinococcus granulosus nuclear receptor nhr 48 0.0096 0.0987 0.1879
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Brugia malayi CXXC zinc finger family protein 0.002 0.0154 0.0536
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0404 0.1407
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0347 0.9853
Schistosoma mansoni cpg binding protein 0.0021 0.0166 0.0305
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0096 0.0987 0.0986
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0019 0.0362
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0166 0.4682
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0204 0.2169 0.756
Brugia malayi hypothetical protein 0.0012 0.0061 0.0211
Brugia malayi bZIP transcription factor family protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0528
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0204 0.2169 0.4124
Entamoeba histolytica hypothetical protein 0.0111 0.1153 0.9985
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0243
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0102 0.2802
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0102 0.2802
Plasmodium falciparum pyruvate kinase 0.0038 0.0347 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0096 0.0987 0.4536
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0227 0.6474
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0204 0.2169 0.7561
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1153 0.1152
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0221 0.0769
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.393
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0119 0.1236 0.1235
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0221 0.1782
Brugia malayi hypothetical protein 0.0011 0.0055 0.0191
Brugia malayi topoisomerase 0.0011 0.0055 0.0191
Brugia malayi Patched related family protein 12 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0102 0.272
Schistosoma mansoni coup transcription factor 0.0204 0.2169 0.4124
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0055 0.1394
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.009
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0055 0.1309
Echinococcus multilocularis nuclear receptor nhr 48 0.0096 0.0987 0.0986
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.2868 0.2868
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0061 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.019 0.3902
Leishmania major cytochrome p450-like protein 0.0025 0.0207 0.5845
Echinococcus multilocularis protein patched 0.0048 0.0457 0.0456
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0791
Echinococcus granulosus GPCR family 2 0.0011 0.0054 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0108 0.1114 0.2112
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0102 0.2802
Schistosoma mansoni microtubule-associated protein tau 0.0485 0.5249 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0102 0.2802
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0055 0.1309
Onchocerca volvulus 0.002 0.0154 0.0681
Echinococcus granulosus nibrin 0.0011 0.0055 0.0102
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0055 0.0817
Entamoeba histolytica hypothetical protein 0.0111 0.1153 0.9985
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0204 0.2169 0.756
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0066
Brugia malayi Carboxylesterase family protein 0.0012 0.0061 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0102 0.2802
Echinococcus multilocularis thyroid hormone receptor alpha 0.0204 0.2169 0.2168
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0243
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0096 0.0987 0.4536
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0204 0.2169 0.756
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0019 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0204 0.2169 0.7561
Schistosoma mansoni hypothetical protein 0.0046 0.0438 0.0823
Brugia malayi Patched related family protein 10 0.0007 0.0007 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.2708 0.944
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0166 0.0576
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0166 1
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0054 0.0188
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.024 0.2566 0.8946
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0108 0.1114 0.3881
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0207 0.5845
Loa Loa (eye worm) hypothetical protein 0.0108 0.1114 0.3881
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0102 0.2802
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0108 0.1114 0.2112
Loa Loa (eye worm) hypothetical protein 0.0043 0.0404 0.1407
Echinococcus multilocularis microtubule associated protein 2 0.0485 0.5249 0.5249
Echinococcus granulosus acetylcholinesterase 0.0069 0.0691 0.1314
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.1155 0.2198
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0055 0.0817
Entamoeba histolytica hypothetical protein 0.0111 0.1153 0.9985
Onchocerca volvulus 0.0204 0.2169 1
Echinococcus granulosus cAMP responsive element binding protein 3 0.0007 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0817
Echinococcus multilocularis expressed protein 0.0023 0.019 0.0189
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.1155 0.1154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0788
Schistosoma mansoni topbp1 0.0011 0.0055 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0204 0.2169 0.4124
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0043 0.0404 0.0403
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0166 0.0578
Echinococcus multilocularis pyruvate kinase 0.0038 0.0347 0.0346
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0102 0.2538
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0102 0.2767
Brugia malayi Carboxylesterase family protein 0.0012 0.0061 0.0211
Schistosoma mansoni cpg binding protein 0.0021 0.0166 0.0305
Loa Loa (eye worm) hypothetical protein 0.0106 0.1097 0.3822
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0102 0.2538
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0204 0.2169 0.7561
Echinococcus granulosus fos transcription factor 0.0007 0.0007 0.0011
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0347 0.1206
Brugia malayi bZIP transcription factor family protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0069 0.0691 0.2405
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0061 0.006
Chlamydia trachomatis pyruvate kinase 0.0038 0.0347 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0054 0.0101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0788
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.6433
Mycobacterium leprae putative cytochrome p450 0.0015 0.0102 0.2538
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Onchocerca volvulus Netrin receptor homolog 0.0043 0.0404 0.184
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0023 0.0184 0.5152
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.1155 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0204 0.2169 0.413
Schistosoma mansoni retinoic acid receptor RXR 0.0204 0.2169 0.4124
Loa Loa (eye worm) carboxylesterase 0.0069 0.0691 0.2405
Brugia malayi nuclear receptor RXR 0.0108 0.1114 0.3883
Brugia malayi Steroid receptor seven-up type 2 0.0204 0.2169 0.7561
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0055 0.1394
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0055 0.0054
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0019 0.0356
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0691 0.069
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0023 0.0184 0.5152
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0096 0.0987 0.0986
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0204 0.2169 0.7561
Onchocerca volvulus 0.0011 0.0055 0.0223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0184 0.1451
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0204 0.2169 0.4124
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0019 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0166 0.4622
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.1114 0.3883
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.6344
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0061 0.0114
Loa Loa (eye worm) hypothetical protein 0.0108 0.1114 0.3881
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Schistosoma mansoni steroid hormone receptor ad4bp 0.0204 0.2169 0.4124
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0207 0.5742
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0019 0.0354
Echinococcus multilocularis pyruvate kinase 0.0038 0.0347 0.0346
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0102 0.2802
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0166 0.3357
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0102 0.2802
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0166 0.1295
Brugia malayi hypothetical protein 0.0007 0.0007 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0402 0.0754
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0143 0.1498 0.5223
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0102 0.2538
Onchocerca volvulus 0.0008 0.0019 0.0057
Onchocerca volvulus Bile acid receptor homolog 0.0204 0.2169 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0227 0.6344
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Onchocerca volvulus 0.0012 0.0061 0.025
Echinococcus granulosus expressed protein 0.0023 0.019 0.036
Loa Loa (eye worm) hypothetical protein 0.0143 0.1498 0.5222
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0019 0.0354
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0054 0.0188
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0204 0.2169 0.2168
Schistosoma mansoni rotamase 0.0023 0.019 0.0349
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0166 0.4622
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0007 0.0007 0.0011
Schistosoma mansoni acetylcholinesterase 0.0012 0.0061 0.0103
Echinococcus multilocularis pyruvate kinase 0.0019 0.0145 0.0144
Toxoplasma gondii peptidylprolyl isomerase 0.0023 0.0184 0.5134
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.1114 0.3883
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0102 0.2538
Brugia malayi Nuclear hormone receptor E75 0.0096 0.0987 0.3442
Loa Loa (eye worm) carboxylesterase 0.0012 0.0061 0.0208
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.0063
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0227 0.183
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0195 0.068
Schistosoma mansoni hypothetical protein 0.0024 0.0195 0.0359
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0102 0.272
Brugia malayi Cytochrome P450 family protein 0.0025 0.0207 0.0722
Brugia malayi Patched related family protein 4 0.0007 0.0007 0.0023
Echinococcus granulosus cyclic AMP dependent transcription factor ATF 6 0.0007 0.0007 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0166 0.0314
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0457 0.0869
Echinococcus multilocularis nuclear factor of activated T cells 5 0.022 0.2349 0.2349
Brugia malayi Death domain containing protein 0.0043 0.0404 0.1409
Schistosoma mansoni DNA ligase IV 0.0011 0.0055 0.0092
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0055 0.1093
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0102 0.2538
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0207 0.0719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0404 0.1409
Toxoplasma gondii histone lysine methyltransferase SET1 0.0038 0.0352 1
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0207 0.5845
Brugia malayi pyruvate kinase 0.0008 0.002 0.0069
Onchocerca volvulus 0.0012 0.0061 0.025
Schistosoma mansoni hypothetical protein 0.0043 0.0404 0.0758
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0055 0.2833
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0204 0.2169 0.413
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0204 0.2169 0.7561
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni ankyrin 23/unc44 0.0043 0.0404 0.0758
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0007 0.0011 0.012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.393
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0204 0.2169 0.7561
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.393
Brugia malayi bZIP transcription factor family protein 0.0007 0.0007 0.0023
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0061 0.006
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0457 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0204 0.2169 0.7561
Trichomonas vaginalis rotamase, putative 0.0023 0.019 0.3902
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0019 0.0356
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Loa Loa (eye worm) steroid hormone receptor 0.0204 0.2169 0.756
Echinococcus granulosus pyruvate kinase 0.0038 0.0347 0.0659
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0102 0.2802
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.0063
Echinococcus multilocularis cpg binding protein 0.0021 0.0166 0.0165
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0102 0.2538
Echinococcus multilocularis nibrin 0.0011 0.0055 0.0054
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0055 0.0191
Echinococcus granulosus jun protein 0.0247 0.264 0.5029
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0791
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0347 0.1206
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0019 0.0354
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus granulosus expressed protein 0.0007 0.0007 0.0011
Onchocerca volvulus 0.0096 0.0987 0.4536
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Loa Loa (eye worm) hypothetical protein 0.0108 0.1114 0.3881
Brugia malayi DKFZp564C0469 protein 0.0011 0.0055 0.0191
Onchocerca volvulus 0.0096 0.0987 0.4536
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0102 0.2538
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0204 0.2169 0.413
Echinococcus multilocularis ecdysone induced protein 78C 0.0204 0.2169 0.2168
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0055 0.1093
Echinococcus granulosus pyruvate kinase 0.0019 0.0145 0.0275
Schistosoma mansoni nuclear hormone receptor 0.0204 0.2169 0.4124
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0055 0.1309
Brugia malayi Carboxylesterase family protein 0.0069 0.0691 0.2407
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0019 0.0243
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0204 0.2169 0.4124
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0055 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0457 1
Brugia malayi hypothetical protein 0.0194 0.2059 0.7178
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi Cytochrome P450 family protein 0.0057 0.0559 0.195
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0061 0.0114
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0102 0.272
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0166 0.4622
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0102 0.2538
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Onchocerca volvulus 0.0008 0.0019 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0102 0.2802
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Echinococcus granulosus acetylcholinesterase 0.0069 0.0691 0.1314
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0188
Echinococcus multilocularis cAMP responsive element binding protein 3 0.0007 0.0007 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.6344
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0055 0.1309
Schistosoma mansoni pyruvate kinase 0.0038 0.0347 0.0648
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.6344
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0247 0.264 0.5029
Brugia malayi tailless protein 0.0096 0.0987 0.3442
Onchocerca volvulus Protein ultraspiracle homolog 0.0204 0.2169 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0204 0.2169 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0817
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0347 1
Schistosoma mansoni pyruvate kinase 0.0038 0.0347 0.0648
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1153 0.2195
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0243
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0204 0.2169 0.413
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0055 0.0102
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Schistosoma mansoni hypothetical protein 0.0015 0.0102 0.0182
Echinococcus granulosus FTZ F1 alpha 0.0204 0.2169 0.413
Brugia malayi ecdysone receptor 0.0096 0.0987 0.3442
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Echinococcus granulosus dnaJ subfamily B 0.0287 0.3084 0.5874
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0102 0.2538
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0166 0.3811
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0788
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0096 0.0987 0.1879
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0152 0.4288
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.0063
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0061 0.0103
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0102 0.2802
Giardia lamblia Pyruvate kinase 0.0038 0.0347 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0096 0.0987 0.3442
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus granulosus microtubule associated protein 2 0.0485 0.5249 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.6433
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0096 0.0987 0.344
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0207 0.0719
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.1679 0.1679
Brugia malayi bZIP transcription factor family protein 0.0007 0.0007 0.0023
Echinococcus granulosus pyruvate kinase 0.0019 0.0145 0.0275
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0691 0.1304
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0102 0.2802
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni cpg binding protein 0.002 0.0154 0.028
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0055 0.0817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Echinococcus granulosus netrin receptor unc 5 0.0043 0.0404 0.0769
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0102 0.2538
Echinococcus multilocularis pyruvate kinase 0.003 0.0259 0.0258
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0096 0.0987 0.0986
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni nuclear receptor nhr-48 0.0096 0.0987 0.187
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0347 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0102 0.2538
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0817
Onchocerca volvulus 0.0008 0.0019 0.0057
Brugia malayi nuclear receptor NHR-88 0.0204 0.2169 0.7561
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0019 0.0354
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0102 0.2538
Brugia malayi nuclear receptor NHR-88 0.0096 0.0987 0.3442
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.183
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0691 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0204 0.2169 0.756
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0023 0.0184 0.5152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0188
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0019 0.0354
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0061 0.0103
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0243
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1153 0.2187
Echinococcus granulosus Nuclear hormone receptor HR96 0.0096 0.0987 0.1879
Echinococcus multilocularis jun protein 0.0247 0.264 0.264
Schistosoma mansoni cytochrome P450 0.0015 0.0102 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.0987 0.1879
Brugia malayi nuclear hormone receptor 0.0096 0.0987 0.3442
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0019 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0204 0.2169 0.756
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0019 0.0356
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0019 0.0354
Loa Loa (eye worm) patched family protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0347 0.1206
Loa Loa (eye worm) hypothetical protein 0.0056 0.0546 0.1903
Brugia malayi hypothetical protein 0.0007 0.0007 0.0023
Echinococcus multilocularis GPCR, family 2 0.0011 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Onchocerca volvulus 0.0194 0.2059 0.9492
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0204 0.2169 0.2168
Brugia malayi cytochrome P450 0.0015 0.0102 0.0356
Schistosoma mansoni jun-related protein 0.0201 0.2133 0.4056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0188
Leishmania major pyruvate kinase 0.0038 0.0347 1
Onchocerca volvulus 0.0056 0.0546 0.2497
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0066
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0227 0.6344
Echinococcus multilocularis neuroligin 0.0012 0.0061 0.006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0166 0.0165
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0102 0.2802
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0204 0.2169 0.756
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0023 0.019 0.0659
Loa Loa (eye worm) carboxylesterase 0.0012 0.0061 0.0208
Echinococcus granulosus Nuclear hormone receptor HR96 0.0096 0.0987 0.1879
Loa Loa (eye worm) patched family protein 0.0007 0.0007 0.002
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0347 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0152 0.4074
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0102 0.2538
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0347 0.1573
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.6433
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0317 0.1101
Schistosoma mansoni hypothetical protein 0.0046 0.0438 0.0823
Brugia malayi protein C24B5.3 0.0007 0.0007 0.0023
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0102 0.2538
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0347 0.1573
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0007 0.0007 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0102 0.2802
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0204 0.2169 0.7561
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0691 0.2405
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.009
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0055 0.0191
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0204 0.2169 0.2168
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Schistosoma mansoni nuclear receptor 0.0096 0.0987 0.187
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0096 0.0987 0.187
Echinococcus multilocularis 0.0015 0.0102 0.0101
Schistosoma mansoni netrin receptor unc5 0.0043 0.0404 0.0758
Loa Loa (eye worm) cytochrome P450 0.0015 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0012 0.0061 0.0951
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0204 0.2169 0.413
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0817
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi hypothetical protein 0.0108 0.1114 0.3883
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0054 0.0185
Brugia malayi hypothetical protein 0.0268 0.2868 1
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0691 0.1314
Mycobacterium ulcerans hypothetical protein 0.0027 0.0227 0.6344
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus multilocularis fos transcription factor 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi hypothetical protein 0.0011 0.0055 0.0191
Schistosoma mansoni pyruvate kinase 0.0019 0.0145 0.0264
Echinococcus multilocularis FTZ F1 alpha 0.0204 0.2169 0.2168
Echinococcus granulosus pyruvate kinase 0.0019 0.0145 0.0275
Schistosoma mansoni nuclear hormone receptor 0.0096 0.0987 0.187
Echinococcus granulosus pyruvate kinase 0.0038 0.0347 0.0659
Loa Loa (eye worm) nuclear receptor NHR-67 0.0096 0.0987 0.344
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0055 0.1415
Schistosoma mansoni hypothetical protein 0.0046 0.0438 0.0823
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0152 0.4283
Echinococcus multilocularis pyruvate kinase 0.0019 0.0145 0.0144
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0145 0.4072
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0207 0.5845
Loa Loa (eye worm) hypothetical protein 0.0024 0.0195 0.0677
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0127
Brugia malayi Carboxylesterase family protein 0.0012 0.0061 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0102 0.2802
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0019 0.0354
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0457 0.0869
Brugia malayi nuclear receptor RXR 0.0096 0.0987 0.3442
Toxoplasma gondii exonuclease III APE 0.0021 0.0166 0.4618
Brugia malayi nuclear hormone receptor 0.0204 0.2169 0.7561
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.1679 0.3198
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0347 1
Echinococcus multilocularis cyclic AMP dependent transcription factor ATF 6 0.0007 0.0007 0.0006
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0061 0.158
Loa Loa (eye worm) bZIP transcription factor family protein 0.0007 0.0007 0.002
Brugia malayi nuclear receptor NHR-67 0.0096 0.0987 0.3442
Brugia malayi hypothetical protein 0.0096 0.0987 0.3442
Echinococcus multilocularis Ankyrin 0.0043 0.0408 0.0407
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0347 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0204 0.2169 0.4124
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0019 0.0023
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0019 0.0066
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0055 0.0092
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0007 0.0007 0.0011
Brugia malayi Uncoordinated protein 44 0.0043 0.0404 0.1409
Brugia malayi nuclear hormone receptor family member odr-7 0.0096 0.0987 0.3442
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0207 0.0719
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0188
Echinococcus multilocularis dnaJ subfamily B 0.0287 0.3084 0.3083
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0019 0.0243
Echinococcus granulosus expressed conserved protein 0.0105 0.1081 0.2057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0204 0.2169 0.4124
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0347 1
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.2868 0.5463
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0102 0.2538
Schistosoma mansoni zinc finger protein 0.0096 0.0987 0.187
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0096 0.0987 0.0986
Echinococcus granulosus death domain containing protein 0.0043 0.0404 0.0769
Schistosoma mansoni ap endonuclease 0.0021 0.0166 0.0304
Brugia malayi hypothetical protein 0.0106 0.1097 0.3824
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0023 0.0184 0.5152
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0227 0.6344
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0061 0.0103
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0188
Loa Loa (eye worm) bZIP transcription factor family protein 0.0007 0.0007 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0817
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0055 0.1415
Schistosoma mansoni hypothetical protein 0.0111 0.1153 0.2187
Onchocerca volvulus 0.0055 0.0531 0.2427
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0102 0.2538
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0204 0.2169 0.7561
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0347 0.748
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0119 0.1236 0.2352
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0102 0.0193
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.1155 0.4026
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0166 0.3357
Loa Loa (eye worm) bZIP transcription factor family protein 0.0007 0.0007 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.0354
Brugia malayi protein C24B5.3 0.0007 0.0007 0.0023
Schistosoma mansoni thyroid hormone receptor 0.0204 0.2169 0.4124
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0347 0.1573
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0145 0.4012
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0347 0.748
Brugia malayi steroid hormone receptor 0.0204 0.2169 0.7561
Echinococcus granulosus ecdysone induced protein 78C 0.0204 0.2169 0.413
Schistosoma mansoni gliotactin 0.0012 0.0061 0.0103
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0347 0.1208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0204 0.2169 0.2168
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0102 0.2538
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0007 0.0007 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0531 0.1852
Brugia malayi Carboxylesterase family protein 0.0012 0.0061 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0204 0.2169 0.756
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0023 0.019 0.0662
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0019 0.0066
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0061 0.0103
Schistosoma mansoni RAR-like nuclear receptor 0.0204 0.2169 0.4124
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0317 0.1104
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0019 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0204 0.2169 0.7561
Schistosoma mansoni thyroid hormone receptor 0.0204 0.2169 0.4124
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus multilocularis expressed conserved protein 0.0105 0.1081 0.108
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi Nuclear hormone receptor E75 0.0096 0.0987 0.3442
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.002 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0066
Echinococcus multilocularis netrin receptor unc 5 0.0043 0.0404 0.0403
Loa Loa (eye worm) patched family protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus granulosus cpg binding protein 0.0021 0.0166 0.0315
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0347 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Leishmania major cytochrome p450-like protein 0.0015 0.0102 0.272
Trichomonas vaginalis rotamase, putative 0.0023 0.0184 0.3763
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi Patched family protein 0.0007 0.0007 0.0023
Brugia malayi hypothetical protein 0.0108 0.1114 0.3883
Entamoeba histolytica hypothetical protein 0.0011 0.0055 0.0315
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.0061 0.158
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0108 0.1114 0.3881
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0204 0.2169 0.7561
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0055 0.0817
Entamoeba histolytica hypothetical protein 0.0111 0.1153 0.9985
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0145 0.4072
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0691 0.069
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0204 0.2169 0.413
Loa Loa (eye worm) oxidoreductase 0.0008 0.0019 0.0063
Echinococcus multilocularis expressed protein 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0208
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0108 0.1114 0.212
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0347 0.1208
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0102 0.272
Onchocerca volvulus 0.0027 0.0227 0.1019
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0043 0.0408 0.0766
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0152 0.3347
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0204 0.2169 0.7561
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0546 0.103
Loa Loa (eye worm) hypothetical protein 0.0096 0.0987 0.344
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi Cytochrome P450 family protein 0.0015 0.0102 0.0356
Schistosoma mansoni hypothetical protein 0.0046 0.0438 0.0823
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0247 0.264 0.264
Echinococcus multilocularis tumor protein p63 0.0383 0.4127 0.4127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0204 0.2169 0.7561
Onchocerca volvulus 0.0012 0.0061 0.025
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0152 0.4288
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.6344
Loa Loa (eye worm) pyruvate kinase 0.0008 0.002 0.0066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0204 0.2169 0.7561
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0061 0.006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0166 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0043 0.0404 0.0769
Loa Loa (eye worm) patched family protein 0.0007 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0188
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0204 0.2169 0.2168
Trichomonas vaginalis spcc417.12 protein, putative 0.0012 0.0061 0.0951
Brugia malayi CHE-14 protein 0.0048 0.0457 0.1593
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.0987 0.0986
Leishmania major cytochrome p450-like protein 0.0015 0.0102 0.272
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.0354
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0528
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi Myosin head containing protein 0.0007 0.0007 0.0023
Schistosoma mansoni hypothetical protein 0.0287 0.3084 0.587
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.009
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0102 0.2538
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0102 0.272
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0102 0.2802
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0102 0.2802
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0457 0.1591
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0102 0.2802
Brugia malayi Patched protein homolog 1 0.0007 0.0007 0.0023
Echinococcus granulosus Ankyrin 0.0043 0.0408 0.0776
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0061 0.158
Loa Loa (eye worm) nuclear hormone receptor 0.0096 0.0987 0.344
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0154 0.0533
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0559 0.1947
Brugia malayi hypothetical protein 0.0007 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0102 0.2802
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0185
Onchocerca volvulus 0.0012 0.0061 0.025
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0227 0.6344
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0102 0.2538
Schistosoma mansoni hypothetical protein 0.0201 0.2133 0.4056
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0528
Brugia malayi Cytochrome P450 family protein 0.0025 0.0207 0.0722
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Echinococcus granulosus tumor protein p63 0.0383 0.4127 0.7862
Brugia malayi Carboxylesterase family protein 0.0069 0.0691 0.2407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0204 0.2169 0.2168
Brugia malayi conserved hypotetical protein 0.0096 0.0987 0.3442
Echinococcus granulosus neuroligin 0.0012 0.0061 0.0114
Loa Loa (eye worm) hypothetical protein 0.0111 0.1155 0.4024
Brugia malayi Protein kinase domain containing protein 0.0043 0.0404 0.1409
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0166 0.4487
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.002
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0058 0.0201
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.009
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0108 0.1114 0.1113
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0166 0.4687
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.6344
Loa Loa (eye worm) hypothetical protein 0.0069 0.0691 0.2405
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0347 0.1206
Loa Loa (eye worm) hypothetical protein 0.0204 0.2169 0.756
Schistosoma mansoni patched 1 0.0048 0.0457 0.0859

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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