Detailed information for compound 86976

Basic information

Technical information
  • TDR Targets ID: 86976
  • Name: N-(2-dimethylaminoethyl)-9-phenylacridine-4-c arboxamide
  • MW: 369.459 | Formula: C24H23N3O
  • H donors: 1 H acceptors: 2 LogP: 4.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1cccc2c1nc1ccccc1c2c1ccccc1)C
  • InChi: 1S/C24H23N3O/c1-27(2)16-15-25-24(28)20-13-8-12-19-22(17-9-4-3-5-10-17)18-11-6-7-14-21(18)26-23(19)20/h3-14H,15-16H2,1-2H3,(H,25,28)
  • InChiKey: OWMIGERTWFJWTP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-dimethylaminoethyl)-9-phenyl-acridine-4-carboxamide
  • N-(2-dimethylaminoethyl)-9-phenyl-4-acridinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0019 0.001 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.001 0.001
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0002 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0017 0.0017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0009 0.0009
Onchocerca volvulus 0.0027 0.002 0.0018
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0195 0.0217 0.0217
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0006
Plasmodium falciparum thioredoxin reductase 0.0056 0.0054 0.9442
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0002 0.0333
Echinococcus granulosus g protein coupled receptor 0.0019 0.001 0.001
Onchocerca volvulus 0.0019 0.001 0.0008
Echinococcus multilocularis dna polymerase eta 0.0022 0.0015 0.0014
Onchocerca volvulus 0.0019 0.001 0.0008
Brugia malayi Bromodomain containing protein 0.0032 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.004 0.004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0142 0.0155 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis serotonin receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0014 0.2384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0056 0.0054 0.0054
Brugia malayi CCR4 0.0012 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0011 0.0012
Plasmodium vivax SET domain protein, putative 0.0064 0.0064 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus allatostatin A receptor 0.0019 0.001 0.001
Brugia malayi hypothetical protein 0.0027 0.002 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.001 0.001
Schistosoma mansoni amine GPCR 0.0019 0.001 0.001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0049 0.0046 0.0045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0057 0.0076
Brugia malayi G-protein coupled receptor 0.0019 0.001 0.001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0064 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.004 0.004
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0009 0.0009
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0011 0.1436
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0011 0.0012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.024 0.027 0.0269
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0011 0.0012
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0263
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0011 0.1891
Echinococcus granulosus GPCR family 2 0.0016 0.0006 0.0006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0006
Echinococcus granulosus orexin receptor type 2 0.0019 0.001 0.001
Brugia malayi ORL1-like opioid receptor 0.0019 0.001 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0057 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.002 0.002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0002 0.0002
Echinococcus granulosus sex peptide receptor 0.0019 0.001 0.001
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0002 0.0333
Echinococcus multilocularis vesicular acetylcholine transporter 0.8554 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.001 0.001
Brugia malayi jmjC domain containing protein 0.0093 0.0097 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0006
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0015 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Brugia malayi hypothetical protein 0.024 0.027 0.0269
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.002 0.002
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0006 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0015 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Brugia malayi Serotonin receptor 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0012 0.0002 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.001 0.001
Giardia lamblia hypothetical protein 0.0012 0.0002 0.0059
Trypanosoma brucei trypanothione reductase 0.0056 0.0054 0.0071
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0011 0.058
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0733 0.0846 0.0846
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0012 0.0002 0.0001
Mycobacterium tuberculosis Probable reductase 0.0128 0.0138 0.8905
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.2151
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0013 0.0014
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0057 0.0057
Echinococcus multilocularis neuropeptide receptor 0.0019 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.001 0.001
Onchocerca volvulus 0.0019 0.001 0.0008
Brugia malayi Dopamine receptor 0.0019 0.001 0.001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.001 0.001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0009 0.0214
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Schistosoma mansoni hypothetical protein 0.0028 0.0022 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.2718 0.317 0.317
Schistosoma mansoni opsin-like receptor 0.0019 0.001 0.001
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0034 0.0983
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0161 0.0177 0.0176
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.2151
Brugia malayi glutathione reductase 0.0056 0.0054 0.0054
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Plasmodium falciparum glutathione reductase 0.0056 0.0054 0.9442
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0015 0.0014
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.001 0.001
Onchocerca volvulus 0.0027 0.002 0.0018
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0012 0.0002 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0009 0.001
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.002 0.002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0 0.00000000086003
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.002 0.002
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0009 0.0009
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0002 0.0015
Echinococcus multilocularis serotonin transporter 0.0161 0.0177 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0015 0.0017
Giardia lamblia GTOR 0.0018 0.0009 0.0271
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0015 0.0226
Leishmania major DNA polymerase kappa, putative 0.0022 0.0015 0.0017
Leishmania major DNA polymerase eta, putative 0.0022 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0161 0.0177 0.0176
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0015 0.0813
Brugia malayi RE15519p 0.0019 0.001 0.001
Loa Loa (eye worm) RecQ helicase 0.0025 0.0017 0.0017
Echinococcus granulosus lamin b receptor 0.0093 0.0097 0.0096
Onchocerca volvulus 0.0019 0.001 0.0008
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.001 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.001 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0006
Trypanosoma cruzi C-8 sterol isomerase, putative 0.6309 0.7373 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0015 0.0813
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.001 0.001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Echinococcus granulosus serotonin receptor 0.0019 0.001 0.001
Onchocerca volvulus Huntingtin homolog 0.024 0.027 0.0268
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0015 0.0226
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0015 0.0015
Plasmodium vivax glutathione reductase, putative 0.0056 0.0054 0.8392
Loa Loa (eye worm) hypothetical protein 0.0161 0.0177 0.0176
Echinococcus granulosus synaptojanin 1 0.0012 0.0002 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0286 0.0323 0.0323
Schistosoma mansoni amine GPCR 0.0019 0.001 0.001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.002 0.002
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Onchocerca volvulus 0.0512 0.0587 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Echinococcus granulosus neuropeptide s receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.002 0.002
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.002 0.002
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0015 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.002 0.002
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0002 0.0002
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0002 0.0015
Giardia lamblia Inositol 5-phosphatase 4 0.0012 0.0002 0.0059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.0138 0.8905
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0009 0.1373
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0009 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.105 0.1217 0.1216
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.001 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0064 0.0064
Onchocerca volvulus 0.0019 0.001 0.0008
Toxoplasma gondii thioredoxin reductase 0.0056 0.0054 0.844
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0015 0.0014
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0011 0.0012
Onchocerca volvulus Alhambra homolog 0.0028 0.0022 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0061 0.0061
Brugia malayi Dopamine receptor protein 2 0.0019 0.001 0.001
Plasmodium falciparum transporter, putative 0.0027 0.002 0.3519
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0117 0.0125 0.0125
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.004 0.004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.001 0.001
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.001 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0002 0.0002
Trypanosoma brucei unspecified product 0.0015 0.0006 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.001 0.001
Onchocerca volvulus 0.0019 0.001 0.0008
Toxoplasma gondii hypothetical protein 0.0027 0.002 0.3145
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0009
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0009
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0002 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0038 0.0037
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.001
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0009 0.0009
Echinococcus multilocularis synaptojanin 1 0.0012 0.0002 0.0002
Schistosoma mansoni nocturnin 0.0012 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0046 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.004 0.004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0064 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0054 0.0054
Echinococcus granulosus g protein coupled receptor 0.0019 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Trypanosoma brucei C-14 sterol reductase, putative 0.0093 0.0097 0.0129
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0034 0.0028 0.0028
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0002 0.0333
Echinococcus multilocularis geminin 0.0733 0.0846 0.0845
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0002 0.0002
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0002 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0045
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0151 0.9785
Schistosoma mansoni amine GPCR 0.0019 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0057 0.0074
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus fmrfamide receptor 0.0019 0.001 0.001
Brugia malayi Abnormal catecholamine distribution protein 1 0.0195 0.0217 0.0217
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0013
Entamoeba histolytica hypothetical protein 0.0024 0.0017 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0006 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Loa Loa (eye worm) hypothetical protein 0.024 0.027 0.0269
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni DNA polymerase eta 0.0022 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.001
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.8554 1 1
Echinococcus multilocularis g protein coupled receptor 0.0019 0.001 0.001
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.002 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0017 0.0016
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Loa Loa (eye worm) acetyltransferase 0.0144 0.0156 0.0156
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0002 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.001 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0038 0.0622
Brugia malayi follicle stimulating hormone receptor 0.0286 0.0323 0.0323
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0001 0.0161
Schistosoma mansoni synaptojanin 0.0012 0.0002 0.0002
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.031 0.031
Brugia malayi Pre-SET motif family protein 0.045 0.0515 0.0514
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.0138 0.8905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0011 0.1891
Onchocerca volvulus 0.0019 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0054 0.8392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0017 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Echinococcus granulosus dna polymerase eta 0.0022 0.0015 0.0014
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.002 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0015 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Brugia malayi Dopamine receptor protein 1 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.0138 0.8905
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0002 0.0001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0054 0.3392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0015 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.0138 0.8905
Brugia malayi AKH receptor 0.0019 0.001 0.001
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0004 0.0003
Brugia malayi Melatonin receptor type 1A 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0019 0.001 0.001
Loa Loa (eye worm) norepinephrine transporter 0.0161 0.0177 0.0176
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0022 0.3354
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0057 0.1716
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0009 0.0009
Brugia malayi GnHR receptor homolog 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni survival motor neuron protein 0.0056 0.0054 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0057 1
Schistosoma mansoni neuropeptide receptor 0.0019 0.001 0.001
Brugia malayi sulfakinin receptor protein 0.0019 0.001 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0029 0.0029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0054 0.0054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.001 0.001
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0004 0.0051
Echinococcus multilocularis somatostatin receptor 0.0019 0.001 0.001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0057 0.0074
Brugia malayi hypothetical protein 0.0275 0.031 0.031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.001 0.001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.001 0.001
Echinococcus granulosus neuropeptide receptor 0.0019 0.001 0.001
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.031 0.031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0038 0.5898
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.002 0.002
Trypanosoma brucei unspecified product 0.0022 0.0015 0.0018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.001 0.001
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0002 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0057 0.0951
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0022 0.315
Echinococcus granulosus tm gpcr rhodopsin 0.105 0.1217 0.1216
Echinococcus granulosus peregrin 0.0032 0.0026 0.0025
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.001 0.001
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0034 0.5872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Echinococcus multilocularis peregrin 0.0032 0.0026 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0007 0.0284
Treponema pallidum sodium- and chloride- dependent transporter 0.0161 0.0177 0.5453
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0002 0.0002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.001 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0071 0.0071
Giardia lamblia PHD finger protein 15 0.0028 0.0022 0.0662
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.045 0.0515 0.0514
Giardia lamblia DINP protein human, muc B family 0.0022 0.0015 0.0444
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0046 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0011 0.0334
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0009 0.0009
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0009 0.0009
Schistosoma mansoni vesicular acetylcholine transporter 0.8554 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0027
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.001 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.001 0.001
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0009 0.0009
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.001 0.001
Echinococcus multilocularis lamin b receptor 0.0093 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0019 0.001 0.001
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0009 0.0009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0005 0.0005
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.002 0.002
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.001 0.001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0156 0.0156
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0064 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Onchocerca volvulus 0.0019 0.001 0.0008
Onchocerca volvulus 0.0019 0.001 0.0008
Echinococcus multilocularis fmrfamide receptor 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0006
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0022 0.0021
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.001 0.001
Onchocerca volvulus 0.0056 0.0054 0.0052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0057 0.8906
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.6309 0.7373 0.7372
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.001 0.001
Brugia malayi putative neuropeptide receptor 0.0019 0.001 0.001
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0022 0.0021
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.001 0.001
Loa Loa (eye worm) solute carrier family 6 member 4 0.0161 0.0177 0.0176
Schistosoma mansoni neuropeptide receptor 0.0019 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0125 0.0125
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0002 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.001 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.001 0.001
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0002 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.001 0.001
Schistosoma mansoni Lamin B receptor (ERG24) 0.0093 0.0097 0.0097
Schistosoma mansoni opsin-like receptor 0.0019 0.001 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0015 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0057 0.3281
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0002 0.0333
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0017 0.0274
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0007 0.1096
Echinococcus multilocularis fmrfamide receptor 0.0019 0.001 0.001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.001 0.001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0015 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0006
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0006
Brugia malayi Pre-SET motif family protein 0.0064 0.0064 0.0063
Schistosoma mansoni synaptojanin 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0015 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0006 0.0006
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni cript-related 0.0012 0.0002 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0038 0.5898
Loa Loa (eye worm) glutathione reductase 0.0056 0.0054 0.0054
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.2151
Echinococcus multilocularis microtubule associated protein 2 0.2718 0.317 0.3169
Plasmodium falciparum phd finger protein, putative 0.0028 0.0022 0.3752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0011 0.0013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0009 0.0009
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Schistosoma mansoni sodium/chloride dependent transporter 0.0161 0.0177 0.0177
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.001 0.001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0009 0.0009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0046 0.0045
Onchocerca volvulus 0.0161 0.0177 0.0174
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0057 0.0057
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.001 0.001
Echinococcus granulosus g-protein coupled receptor 0.0019 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0002 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0027 0.002 0.2935
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.002 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.001 0.001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0006
Schistosoma mansoni ap endonuclease 0.0059 0.0057 0.0057
Trypanosoma brucei C-8 sterol isomerase, putative 0.6309 0.7373 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0028 0.0027
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.002 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0017 0.0274
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0142 0.0155 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.001 0.001
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0022 0.0022
Schistosoma mansoni myosin xvIII 0.0019 0.001 0.001
Leishmania major C-8 sterol isomerase-like protein 0.6309 0.7373 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.002 0.002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.001 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni amine GPCR 0.0019 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0017 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0029 0.0028
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0011 0.0166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Brugia malayi ERG2 and Sigma1 receptor like protein 0.6309 0.7373 0.7372
Schistosoma mansoni neuropeptide receptor 0.0019 0.001 0.001
Onchocerca volvulus 0.0019 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.3225 0.3762 0.3762
Schistosoma mansoni vesicular amine transporter 0.0195 0.0217 0.0217
Brugia malayi neuropeptide F receptor 0.0019 0.001 0.001
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.0322 1
Echinococcus multilocularis orexin receptor type 2 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0703
Brugia malayi Serotonin receptor 0.0019 0.001 0.001
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0017 0.0016
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0054 0.007
Echinococcus multilocularis g protein coupled receptor 0.0019 0.001 0.001
Trichomonas vaginalis set domain proteins, putative 0.0512 0.0587 1
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.002 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0071 0.0071
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.001 0.001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.001 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.002 0.002
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0002 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.001 0.001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0009 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Onchocerca volvulus 0.0019 0.001 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0011 0.0166
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0152 0.0151
Brugia malayi G protein-coupled receptor 0.0019 0.001 0.001
Brugia malayi jmjC domain containing protein 0.0034 0.0029 0.0028
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0022 0.0021
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0035 0.0034
Brugia malayi neuropeptide F receptor 0.0019 0.001 0.001
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0008 0.0935
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.004 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0057 0.0951
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0015 0.0017
Echinococcus granulosus vesicular acetylcholine transporter 0.8554 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0151 1
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0009 0.001
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.002 0.002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.001 0.001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.3145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0009 0.0009
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.001 0.001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0011 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0015 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0008 0.1168
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.001 0.001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0057 0.1764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.004 0.004
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0009 0.0009
Brugia malayi PHD-finger family protein 0.0028 0.0022 0.0021
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.001 0.001
Trypanosoma brucei RNA editing exonuclease 2 0.0012 0.0002 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0017 0.0021
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0006
Echinococcus multilocularis neuropeptide receptor 0.0019 0.001 0.001
Echinococcus granulosus serotonin transporter 0.0161 0.0177 0.0176
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.001 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0054 0.0054
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0322 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0097 0.0097
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0002 0.0002
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0064 0.0064 0.0063
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.0138 0.8905
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0004 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Plasmodium falciparum glutathione reductase 0.0019 0.0011 0.1891
Echinococcus granulosus neuropeptide receptor 0.0019 0.001 0.001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0064 0.0063
Echinococcus granulosus somatostatin receptor 0.0019 0.001 0.001
Schistosoma mansoni neuropeptide receptor 0.0019 0.001 0.001
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.002 0.002
Onchocerca volvulus Huntingtin homolog 0.024 0.027 0.0268
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0002 0.0015
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0002 0.0297
Brugia malayi hypothetical protein 0.0071 0.0071 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0015 0.0253
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0156 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0064 0.0064
Echinococcus granulosus g protein coupled receptor 0.0019 0.001 0.001
Leishmania major sterol C-24 reductase, putative 0.0048 0.0045 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0057 0.0057
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.001 0.0008
Echinococcus multilocularis allatostatin A receptor 0.0019 0.001 0.001
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Echinococcus multilocularis sex peptide receptor 0.0019 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0142 0.0155 1
Brugia malayi G-protein coupled receptor 0.0019 0.001 0.001
Trypanosoma brucei unspecified product 0.0015 0.0006 0.0007
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.001 0.001
Plasmodium vivax amine transporter, putative 0.0027 0.002 0.2935
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0161 0.0177 0.0176
Plasmodium falciparum amino acid transporter, putative 0.0027 0.002 0.3519
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0064 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0097 0.0097
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0057 0.36
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0038 0.0622
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.001 0.001
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0009 0.0009
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0045 0.0058
Echinococcus granulosus dna polymerase kappa 0.0022 0.0015 0.0014
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0029 0.0028
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0038 0.5772
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Treponema pallidum NADH oxidase 0.0019 0.0011 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0979
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Onchocerca volvulus 0.0064 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0002 0.0002
Brugia malayi larval opioid receptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni histamine h1 receptor 0.0019 0.001 0.001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.001 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0142 0.0155 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0015 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.001 0.001
Onchocerca volvulus 0.0027 0.002 0.0018
Leishmania major C-14 sterol reductase, putative 0.0093 0.0097 0.0128
Onchocerca volvulus 0.0019 0.001 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0057 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.002
Toxoplasma gondii exonuclease III APE 0.0059 0.0057 0.8939
Onchocerca volvulus 0.0019 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0019 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0019 0.001 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.004 0.004
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.8554 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0011 0.1691
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.001 0.001
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0009 0.001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.3145
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.002 0.002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0015 0.0014
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.001 0.001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0015 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0015 0.0017
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0011 0.0012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.2151
Echinococcus granulosus synaptic vesicular amine transporter 0.0195 0.0217 0.0217
Echinococcus granulosus bloom syndrome protein 0.0025 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0125 0.0125
Echinococcus granulosus hypothetical protein 0.0019 0.001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0161 0.0177 0.0177
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0034 0.1036
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.001 0.001
Loa Loa (eye worm) serotonin transporter b 0.0161 0.0177 0.0176
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0017 0.2592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.004 0.004
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0009 0.0009
Plasmodium falciparum thioredoxin reductase 0.0019 0.0011 0.1891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Brugia malayi Thioredoxin reductase 0.0056 0.0054 0.0054
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0011 0.1436
Onchocerca volvulus 0.0019 0.001 0.0008
Echinococcus granulosus jumonji domain containing protein 0.004 0.0035 0.0034
Toxoplasma gondii hypothetical protein 0.0027 0.002 0.3145
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0097 0.0128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0029 0.0029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0733 0.0846 0.0846
Echinococcus granulosus geminin 0.0733 0.0846 0.0845
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0057 0.0057
Onchocerca volvulus 0.0019 0.001 0.0008
Onchocerca volvulus 0.0019 0.001 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0006 0.0007
Echinococcus multilocularis serotonin receptor 0.0019 0.001 0.001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.001 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0022 0.3354
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0011 0.1691
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0151 0.8038
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0002 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.001 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.004 0.004
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0029 0.0028
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0097 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0131
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.001 0.001
Schistosoma mansoni adenoreceptor 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0275 0.031 0.031
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0004 0.0002
Echinococcus granulosus microtubule associated protein 2 0.2718 0.317 0.3169
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.001 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0057 0.1716
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0002 0.0015
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0045 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.001 0.001
Echinococcus multilocularis GPCR, family 2 0.0016 0.0006 0.0006
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0002 0.0002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0009 0.0009
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.3145
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0002 0.0015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.001 0.001
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.0322 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0979
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0006 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.001 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0002 0.0002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.001 0.001
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0322 0.5473
Schistosoma mansoni ap endonuclease 0.0059 0.0057 0.0057
Echinococcus multilocularis synaptic vesicular amine transporter 0.0195 0.0217 0.0217
Leishmania major trypanothione reductase 0.0056 0.0054 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0015 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1200 nM Inhibitory concentration required to reduce Lewis lung carcinoma cell number to 50% of control cultures ChEMBL. 9191970
IC50 (functional) = 1370 nM Concentration required to inhibit growth of murine leukemia (L1210) cells in culture ChEMBL. 3351846
IC50 (functional) = 1370 nM Inhibition of L1210 cell growth by 50% ChEMBL. 11831901
IC50 (functional) = 1370 nM Concentration required to inhibit growth of murine leukemia (L1210) cells in culture ChEMBL. 3351846
IC50 (functional) = 1370 nM Inhibition of L1210 cell growth by 50% ChEMBL. 11831901
IC50 (functional) = 2700 nM Inhibitory concentration required to reduce human Jurkat leukemia (JLC sensitive, wild type) cell number to 50% of control cultures ChEMBL. 9191970
IC50 (functional) = 2700 nM Inhibitory concentration required to reduce human Jurkat leukemia (JLC sensitive, wild type) cell number to 50% of control cultures ChEMBL. 9191970
IC50 (functional) = 4100 nM Inhibitory concentration required to reduce murine p388 leukemia cell number to 50% of control cultures ChEMBL. 9191970
IC50 (functional) = 4100 nM Inhibitory concentration required to reduce murine p388 leukemia cell number to 50% of control cultures ChEMBL. 9191970
ILS (functional) = 99 % Percent increase in life span ofcompound-treated mice bearing P388 leukemia or Lewis lung carcinoma ChEMBL. 11831901
ILS (functional) = 99 % Percent increase in life span ofcompound-treated mice bearing P388 leukemia or Lewis lung carcinoma ChEMBL. 11831901
ILS max (functional) 0 Percentage increase in lifespan of P388 tumor cell bearing animal compared to nontreated tumor bearing controls at given optimal dose; Not active ChEMBL. 3351846
Log K (binding) = 5.84 Binding constant for DNA by ethidium displacement ChEMBL. 3351846
Log K (binding) = 5.84 Binding constant to Poly (dA-dT) determined by ethidium bromide displacement ChEMBL. 11831901
Log K (binding) = 5.98 Binding constant for DNA by ethidium displacement ChEMBL. 3351846
Log K (binding) = 5.98 Binding constant to Poly (dG-dC) determined by ethidium bromide displacement ChEMBL. 11831901
ND (functional) 0 Percent increase in life span of compound-treated mice bearing or Lewis lung carcinoma; ND denotes no data. ChEMBL. 11831901
OD (functional) = 65 mg kg-1 Optimal dose administered intraperitoneally after intraperitoneal inoculation of 10 e 6 P388 leukemia cells ChEMBL. 3351846
OD (functional) = 65 mg kg-1 Optimal dose administered intraperitoneally after intraperitoneal inoculation of 10 e 6 P388 leukemia cells ChEMBL. 3351846
pK = 3.49 Lipophilicity expressed as the negative logarithm of the equilibrium constant ChEMBL. 11831901
Pka = 3.49 Compound was evaluated for ionizable constant, pKa ChEMBL. 3351846
Ratio (functional) = 0.8 Ratio of IC50 of Jurkat leukemia amsacrine (JLA) to the IC50 of Jurkat leukemia (JLC sensitive, wild type) ChEMBL. 9191970
Ratio (functional) = 1.1 Ratio of IC50 of mutant Jurkat leukemia (JLD) to the IC50 of Jurkat leukemia (JLC sensitive, wild type) ChEMBL. 9191970

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9191970
Mus musculus ChEMBL23 11831901

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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