Detailed information for compound 915822

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 566.507 | Formula: C28H29N3O5Se
  • H donors: 3 H acceptors: 3 LogP: 1.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1O)c1ccc2c(c1)NC(=O)/C/2=C\c1[se]c(c(c1)C(=O)NCCN1CCOCC1)C
  • InChi: 1S/C28H29N3O5Se/c1-17-22(27(33)29-7-8-31-9-11-36-12-10-31)15-20(37-17)16-23-21-5-3-18(13-24(21)30-28(23)34)19-4-6-25(32)26(14-19)35-2/h3-6,13-16,32H,7-12H2,1-2H3,(H,29,33)(H,30,34)/b23-16-
  • InChiKey: ZNNHPDWDBDFEQM-KQWNVCNZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.01 0.0097
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0177 0.0175
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0019 0.0104 0.0233
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.002 0.0017
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.019 0.0187
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.0018 0.0035
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0104 0.0104
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0086 0.0084
Plasmodium falciparum aldo-keto reductase, putative 0.0009 0.0033 0.003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.002 0.0017
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.007 0.0067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.0478 0.0475
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.011 0.0659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0104 0.0101
Echinococcus granulosus aldehyde reductase 0.0022 0.0126 0.0123
Chlamydia trachomatis thioredoxin reductase 0.0019 0.0104 0.2016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.01 0.0097
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.0478 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0104 0.0101
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.017 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0007 0.0004
Trichomonas vaginalis glutathione reductase, putative 0.0072 0.0478 0.0475
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0477 0.3322 0.8987
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.019 0.0187
Mycobacterium leprae conserved hypothetical protein 0.002 0.011 0.0289
Toxoplasma gondii endonuclease IV APN 0.0076 0.0504 0.0504
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.007 0.0067
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.0018 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0622 0.4348 1
Echinococcus multilocularis glutamate synthase 0.0019 0.0104 0.0101
Schistosoma mansoni lamin 0.0027 0.0157 0.0155
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0019 0.0104 0.0233
Schistosoma mansoni hypothetical protein 0.0168 0.1153 0.1151
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0104 0.0101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.01 0.0097
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0048 0.0046
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0104 0.0101
Treponema pallidum NADH oxidase 0.0072 0.0478 1
Loa Loa (eye worm) oxidoreductase 0.0031 0.019 0.0187
Trypanosoma brucei trypanothione reductase 0.0209 0.1439 0.1436
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.1426 1 1
Leishmania major hypothetical protein, conserved 0.0019 0.0104 0.0101
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0072 0.0478 0.1094
Brugia malayi glutathione reductase 0.0209 0.1439 0.1436
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0104 0.0101
Echinococcus granulosus aldo keto reductase 0.0031 0.019 0.0187
Brugia malayi Cytochrome P450 family protein 0.0007 0.0018 0.0015
Brugia malayi Pre-SET motif family protein 0.003 0.0177 0.0175
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0007 0.0004
Onchocerca volvulus 0.0031 0.019 0.1155
Echinococcus granulosus lamin 0.0027 0.0157 0.0155
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1424 0.1421
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0104 0.0101
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0072 0.0478 0.0475
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.0478 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0104 0.0099
Echinococcus granulosus Ankyrin 0.0014 0.007 0.0067
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0104 0.0101
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0104 0.0104
Schistosoma mansoni DNA helicase recq5 0.0009 0.003 0.0028
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0118 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.01 0.0097
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0019 0.0104 0.0274
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0483 0.0481
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.003 0.0028
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0104 0.0101
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.1426 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.0057
Onchocerca volvulus 0.003 0.0177 0.1076
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0056 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.0175
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0033 0.003
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0226 0.0224
Toxoplasma gondii aldo-keto reductase 0.0009 0.0033 0.0033
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0477 0.3322 0.7638
Echinococcus multilocularis tumor protein p63 0.0336 0.2331 0.2329
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0104 0.0101
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0043 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0043 0.0041
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.0018 0.0035
Echinococcus multilocularis lamin 0.0027 0.0157 0.0155
Entamoeba histolytica aldose reductase, putative 0.0031 0.019 0.019
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0018 0.0035
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.002 0.0017
Schistosoma mansoni hypothetical protein 0.0168 0.1153 0.1151
Loa Loa (eye worm) RecQ helicase 0.0021 0.0118 0.0115
Giardia lamblia NADH oxidase lateral transfer candidate 0.0072 0.0478 0.0475
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.053 0.3696 0.8499
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0104 0.0101
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0104 0.0233
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.019 0.0507
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.019 0.0187
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0104 0.0233
Loa Loa (eye worm) hypothetical protein 0.0027 0.0157 0.0155
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.002 0.0017
Echinococcus multilocularis 0.0007 0.0018 0.0015
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0007 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.01 0.0224
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0118 0.0115
Plasmodium falciparum glutathione reductase 0.0209 0.1439 0.1436
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0018 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0005 0.0003 0.0003
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0043 0.0041
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.01 0.01
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Probable dehydrogenase 0.0477 0.3322 0.7638
Echinococcus granulosus aldo keto reductase 0.0031 0.019 0.0187
Leishmania major prostaglandin f synthase, putative 0.0031 0.019 0.0187
Brugia malayi Protein kinase domain containing protein 0.0015 0.0073 0.007
Loa Loa (eye worm) oxidoreductase 0.0031 0.019 0.0187
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0504 0.0502
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0019 0.0104 0.0233
Schistosoma mansoni intermediate filament proteins 0.0027 0.0157 0.0155
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.0018 0.0035
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0072 0.0478 0.0475
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.01 0.205
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0104 0.0101
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0005 0.0003 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.0209 0.1439 0.1436
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0104 0.0101
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0104 0.0104
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0069 0.0066
Mycobacterium ulcerans glutamate synthase subunit beta 0.0019 0.0104 0.0233
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0033 0.003
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.0018 0.0035
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.1426 1 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.025 0.0248
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0069 0.0066
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.019 0.0187
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0043 0.0041
Leishmania major aldo-keto reductase-like protein 0.0031 0.019 0.0187
Echinococcus granulosus microtubule associated protein 2 0.0686 0.4793 0.4792
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0009 0.0007
Echinococcus multilocularis 0.1426 1 1
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0018 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0177 0.0175
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0477 0.3322 0.7638
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0019 0.0104 0.0233
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0104 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0177 0.0175
Trypanosoma brucei aldo/keto reductase, putative 0.0009 0.0033 0.003
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0043 0.0041
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0072 0.0478 0.0475
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.0478 0.0475
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0504 0.1359
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0043 0.0041
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.019 0.0187
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.011 0.0246
Loa Loa (eye worm) AGC/PKG protein kinase 0.0005 0.0007 0.0004
Onchocerca volvulus 0.0027 0.0157 0.0952
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0033 0.0033
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.002 0.0017
Brugia malayi Uncoordinated protein 44 0.0014 0.0069 0.0066
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.003 0.0028
Onchocerca volvulus 0.0235 0.1625 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0018 0.0035
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0104 0.0101
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.003 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.0009 0.003 0.0028
Onchocerca volvulus 0.0031 0.019 0.1155
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0066
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0393 0.0898
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0033 0.003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0018 0.0035
Schistosoma mansoni glutamate synthase 0.0019 0.0104 0.0101
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0104 0.0274
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.002 0.0017
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0019 0.0104 0.0233
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0033 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0041
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0079 0.0077
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0053 0.0343 0.034
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0033 0.003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0104 0.0101
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.1426 1 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0104 0.0101
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.01 0.0097
Mycobacterium leprae putative cytochrome p450 0.0007 0.0018 0.0042
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0104 0.0104
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0018 0.0035
Echinococcus granulosus lamin dm0 0.0027 0.0157 0.0155
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.01 0.0097
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0104 0.0104
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0018 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Brugia malayi Egg laying defective protein 4 0.0005 0.0007 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.021 0.1449 0.1447
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.1426 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.006 0.0057
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0079 0.0077
Giardia lamblia Glutamate synthase 0.0019 0.0104 0.0101
Echinococcus multilocularis musashi 0.0027 0.0157 0.0155
Schistosoma mansoni potassium channel beta 0.0009 0.0033 0.003
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Echinococcus multilocularis aldo keto reductase 0.0031 0.019 0.0187
Toxoplasma gondii aldose reductase, putative 0.0031 0.019 0.019
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0393 0.0391
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.0018 0.0035
Loa Loa (eye worm) oxidoreductase 0.0031 0.019 0.0187
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0019 0.0104 0.0233
Brugia malayi Pre-SET motif family protein 0.0207 0.1424 0.1421
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0018 0.0015
Leishmania major protein kinase, putative 0.0005 0.0007 0.0004
Loa Loa (eye worm) cytochrome P450 0.0007 0.0018 0.0015
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.1426 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0033 0.003
Brugia malayi Cytochrome P450 family protein 0.0016 0.0079 0.0077
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0104 0.0104
Brugia malayi Thioredoxin reductase 0.0209 0.1439 0.1436
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0069 0.0067
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.4793 0.4792
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0072 0.0478 0.0475
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0068 0.0068
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0393 0.0393
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0118 0.0115
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0069 0.0066
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.0018 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.021 0.1449 0.1447
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.1426 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0104 0.0101
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0069 0.0066
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0104 0.0101
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.1426 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0072 0.0478 0.1094
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.011 0.0246
Plasmodium falciparum cGMP-dependent protein kinase 0.0005 0.0007 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.002 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0393 0.0898
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.0175
Leishmania major protein kinase, putative 0.0005 0.0007 0.0004
Plasmodium vivax thioredoxin reductase, putative 0.0209 0.1439 0.1436
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0018 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.019 0.0431
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0019 0.0104 0.0099
Plasmodium vivax aldehyde reductase, putative 0.0009 0.0033 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.007 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.004 0.025 0.0248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.003
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0033 0.003
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0005 0.0003 0.0003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0177 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0018 0.0035
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0104 0.0101
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0072 0.0478 0.0478
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0104 0.0101
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.0018 0.0035
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0019 0.0104 0.0101
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0104 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0088 0.0085
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.002 0.0017
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.002 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.01 0.0224
Mycobacterium tuberculosis Probable reductase 0.0477 0.3322 0.7638
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.002 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0079 0.0077
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.1604 0.1602
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0104 0.0101
Onchocerca volvulus 0.0031 0.019 0.1155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Plasmodium falciparum glutathione reductase 0.0072 0.0478 0.0475
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus intermediate filament protein 0.0027 0.0157 0.0155
Echinococcus granulosus glutamate synthase 0.0019 0.0104 0.0101
Schistosoma mansoni cytochrome P450 0.0007 0.0018 0.0015
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.002 0.0017
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.0018 0.0035
Plasmodium falciparum aldehyde reductase, putative 0.0009 0.0033 0.003
Giardia lamblia Aldose reductase 0.0031 0.019 0.0187
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0104 0.0101
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0019 0.0104 0.0274
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0101
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.1426 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.003 0.0028
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.0018 0.0035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.0018 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.053 0.3696 0.8499
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.0018 0.0035
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.003 0.0028
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0104 0.0101
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0072 0.0478 0.1094
Toxoplasma gondii thioredoxin reductase 0.0209 0.1439 0.1439
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0072 0.0478 0.9473
Mycobacterium ulcerans monoxygenase 0.0019 0.0104 0.0233
Mycobacterium ulcerans NADH dehydrogenase 0.0019 0.0104 0.0233
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.1426 1 1
Echinococcus multilocularis aldo keto reductase 0.0031 0.019 0.0187
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0048 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0018 0.0035
Mycobacterium ulcerans oxidoreductase 0.0031 0.019 0.0431
Echinococcus multilocularis Ankyrin 0.0014 0.007 0.0067
Giardia lamblia Thioredoxin reductase 0.0019 0.0104 0.0101
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.0018 0.0035
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0017
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.019 0.0187
Mycobacterium ulcerans hypothetical protein 0.0622 0.4348 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0072 0.0478 0.0475
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0018 0.0035
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0018 0.0035
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.019 0.0187
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.01 0.0097
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.019 0.0187
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0018 0.0035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0104 0.0101
Toxoplasma gondii selenide, water dikinase 0.0019 0.0104 0.0104
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0104 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0104 0.0101
Echinococcus multilocularis aldo keto reductase 0.0031 0.019 0.0187
Brugia malayi follicle stimulating hormone receptor 0.0232 0.1604 0.1602
Onchocerca volvulus 0.0027 0.0157 0.0952
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.01 0.0097
Chlamydia trachomatis endonuclease IV 0.0076 0.0504 1
Echinococcus granulosus death domain containing protein 0.0014 0.0069 0.0066
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0053 0.0343 0.034
Entamoeba histolytica aldose reductase, putative 0.0031 0.019 0.019
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0157 0.0155
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.002 0.0017
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0393 0.0898
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0104 0.0101
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.1426 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.019 0.0187
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0018 0.0035
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0072 0.0478 0.0475
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Schistosoma mansoni ap endonuclease 0.0019 0.01 0.0097
Schistosoma mansoni 60S ribosomal protein L21 0.0006 0.0009 0.0007
Treponema pallidum oxidoreductase 0.0019 0.0104 0.2128
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.1426 1 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0154 0.0151
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.1426 1 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0033 0.003
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.002 0.0017
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0504 0.0502
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0104 0.0101
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0019 0.0104 0.0101
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.0478 0.0475
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0072 0.0478 0.0475
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0104 0.0101
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0018 0.0015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.007 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.0478 0.0475
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0104 0.0104
Brugia malayi intermediate filament protein 0.0027 0.0157 0.0155
Loa Loa (eye worm) hypothetical protein 0.0076 0.0504 0.0502
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.01 0.0097
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0043 0.0041
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0104 0.0101
Schistosoma mansoni ap endonuclease 0.0019 0.01 0.0097
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0104 0.0101
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0104 0.0101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0157 0.0155
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0072 0.0478 0.0475
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0104 0.0104
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0314 0.0312
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0018 0.0035
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0504 0.0502
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Echinococcus multilocularis aldo keto reductase 0.0031 0.019 0.0187
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0118 0.0115
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.1426 1 1
Leishmania major hypothetical protein, conserved 0.0019 0.0104 0.0101
Loa Loa (eye worm) oxidoreductase 0.0031 0.019 0.0187
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0104 0.0101
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.011 0.0107
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.01 0.0097
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.002 0.0017
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0104 0.0101
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0069 0.0066
Schistosoma mansoni pol-related 0.0031 0.019 0.0187
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.002 0.0017
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0104 0.0101
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0033 0.003
Mycobacterium ulcerans hypothetical protein 0.0009 0.0033 0.0069
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0393 0.0391
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0018 0.0015
Schistosoma mansoni hypothetical protein 0.0014 0.0069 0.0066
Onchocerca volvulus 0.0049 0.0314 0.1921
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0048 0.0046
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1625 0.1622
Onchocerca volvulus 0.0031 0.019 0.1155
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0079 0.0077
Plasmodium falciparum thioredoxin reductase 0.0072 0.0478 0.0475
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0069 0.0409
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0072 0.0478 0.0475
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0033 0.0033
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.002 0.0017
Schistosoma mansoni glutamate synthase 0.0019 0.0104 0.0101
Trypanosoma cruzi trypanothione reductase, putative 0.0209 0.1439 0.1436
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.002 0.0017
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.0018 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0018 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0393 0.0391
Echinococcus granulosus aldo keto reductase 0.0031 0.019 0.0187
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0104 0.0101
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0069 0.0066
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0019 0.0104 0.0233
Echinococcus multilocularis expressed conserved protein 0.0005 0.0007 0.0004
Echinococcus granulosus cGMP dependent protein kinase 0.0005 0.0007 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0177 0.0177
Giardia lamblia Aldose reductase 0.0031 0.019 0.0187
Plasmodium falciparum thioredoxin reductase 0.0209 0.1439 0.1436
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0019 0.0104 0.0233
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0033 0.003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0079 0.0176
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.01 0.0097
Onchocerca volvulus 0.0009 0.0033 0.0185
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.019 0.0187
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.011 0.0107
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0104 0.0099
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0104 0.0101
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.019 0.0187
Onchocerca volvulus 0.0019 0.0104 0.0623
Onchocerca volvulus 0.0031 0.019 0.1155
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0009 0.0033 0.003
Leishmania major cytochrome p450-like protein 0.0016 0.0079 0.0077
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0104 0.0104
Echinococcus multilocularis lamin dm0 0.0027 0.0157 0.0155
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.003 0.0028
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0104 0.0104
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0104 0.0101
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.003
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.019 0.0187
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.019 0.0187
Onchocerca volvulus 0.0031 0.019 0.1155
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0012 0.0056 0.0053
Mycobacterium tuberculosis Conserved protein 0.0009 0.0033 0.0069
Mycobacterium ulcerans epimerase 0.002 0.011 0.0246
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0009 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0192 0.019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.0175
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0202 0.139 0.1388
Entamoeba histolytica aldose reductase, putative 0.0031 0.019 0.019
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0104 0.0104
Brugia malayi Protein kinase domain containing protein 0.0202 0.139 0.1388
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0104 0.0101
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.006 0.0057
Brugia malayi glutamate synthase 0.0019 0.0104 0.0101
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0019 0.0104 0.0233
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0157 0.0155
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0104 0.0101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Plasmodium vivax SET domain protein, putative 0.003 0.0177 0.0175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0314 0.0312
Brugia malayi Cytochrome P450 family protein 0.0016 0.0079 0.0077
Leishmania major cytochrome p450-like protein 0.0007 0.0018 0.0015
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0033 0.003
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0104 0.0101
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0019 0.0104 0.0233
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.053 0.3696 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0009 0.0033 0.003
Schistosoma mansoni hypothetical protein 0.0007 0.0018 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0018 0.0035
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0019 0.0104 0.0274
Mycobacterium ulcerans hypothetical protein 0.002 0.011 0.0246
Trypanosoma brucei prostaglandin f synthase 0.0031 0.019 0.0187
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0477 0.3322 0.7638
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.1426 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Leishmania major cytochrome p450-like protein 0.0007 0.0018 0.0015
Echinococcus multilocularis geminin 0.0168 0.1153 0.1151
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.002 0.0017
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0226 0.0224
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0226 0.0224
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.0018 0.0035
Schistosoma mansoni DNA helicase recq1 0.0009 0.003 0.0028
Echinococcus granulosus hypothetical protein 0.0031 0.019 0.0187
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0007 0.0004
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0033 0.003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0018 0.0015
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0018 0.0035
Brugia malayi Death domain containing protein 0.0014 0.0069 0.0066
Toxoplasma gondii exonuclease III APE 0.0019 0.01 0.01
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0048 0.0048
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0007 0.0004
Plasmodium vivax glutathione reductase, putative 0.0209 0.1439 0.1436
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.0018 0.0035
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.021 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0104 0.0101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0104 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0187
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0104 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0018 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0007 0.0004
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0104 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0393 0.0898
Mycobacterium leprae Possible oxidoreductase 0.0009 0.0033 0.0081
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0104 0.0101
Leishmania major trypanothione reductase 0.0209 0.1439 0.1436
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0079 0.0077
Loa Loa (eye worm) hypothetical protein 0.003 0.0177 0.0175
Trypanosoma cruzi trypanothione reductase, putative 0.0072 0.0478 0.0475
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0209 0.1439 0.3304
Echinococcus multilocularis aldehyde reductase 0.0022 0.0126 0.0123
Mycobacterium ulcerans endonuclease IV 0.0076 0.0504 0.1155
Schistosoma mansoni glutamate synthase 0.0019 0.0104 0.0101
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.019 0.0187
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0104 0.0101
Brugia malayi cytochrome P450 0.0007 0.0018 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0018 0.0035
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0072 0.0478 0.0475
Toxoplasma gondii NADPH-glutathione reductase 0.0072 0.0478 0.0478
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0072 0.0478 0.0475
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.002 0.0017
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.003 0.0028
Mycobacterium ulcerans hypothetical protein 0.0019 0.0104 0.0233
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.002 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Schistosoma mansoni netrin receptor unc5 0.0014 0.0069 0.0066
Echinococcus granulosus geminin 0.0168 0.1153 0.1151
Schistosoma mansoni aldo-keto reductase 0.0031 0.019 0.0187
Echinococcus granulosus tumor protein p63 0.0336 0.2331 0.2329
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0018 0.0035
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0104 0.0233
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0005 0.0007 0.0007
Schistosoma mansoni aldo-keto reductase 0.0031 0.019 0.0187
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.021 0.0207
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0005 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.01 0.0097
Trypanosoma cruzi aldo-keto reductase 0.0031 0.019 0.0187
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0048 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.4793 0.4792
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0072 0.0478 0.1094
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.019 0.0187
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0104 0.0101
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.0028
Loa Loa (eye worm) glutathione reductase 0.0209 0.1439 0.1436
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.0018 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0393 0.0391
Echinococcus granulosus bloom syndrome protein 0.0021 0.0118 0.0115
Treponema pallidum thioredoxin reductase (trxB) 0.0019 0.0104 0.2128
Mycobacterium ulcerans dehydrogenase 0.0019 0.0104 0.0233
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0393 0.0391
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.019 0.0187
Leishmania major NADH dehydrogenase, putative 0.0019 0.0104 0.0101
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0069 0.0066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.0478 0.0475
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.01 0.0097
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0483 0.0481
Loa Loa (eye worm) oxidoreductase 0.0031 0.019 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.139 0.1388
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.002 0.0017
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0104 0.0101
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0126 0.0334
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0104 0.0101
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0072 0.0478 0.0475
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0018 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.003
Brugia malayi Cytochrome P450 family protein 0.0007 0.0018 0.0015
Mycobacterium ulcerans ferredoxin reductase 0.0019 0.0104 0.0233
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.0018 0.0035
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0104 0.0104
Schistosoma mansoni lamin 0.0027 0.0157 0.0155
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0504 0.1155
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0079 0.0077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0477 0.3322 0.7638
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.1426 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.053 0.3696 0.8499
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0226 0.0224
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.019 0.0187
Trichomonas vaginalis mercuric reductase, putative 0.0072 0.0478 0.0475

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 nM Inhibition of human recombinant GST-Chk1after 30 mins ChEMBL. 20674356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.