Detailed information for compound 922313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.464 | Formula: C23H24F3N5O3
  • H donors: 1 H acceptors: 2 LogP: 1.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)c1cc(C(Nc2cc(F)c(c(c2)F)F)C)c2n(c1)c(=O)cc(n2)N1CCOCC1)C
  • InChi: 1S/C23H24F3N5O3/c1-13(27-15-9-17(24)21(26)18(25)10-15)16-8-14(23(33)29(2)3)12-31-20(32)11-19(28-22(16)31)30-4-6-34-7-5-30/h8-13,27H,4-7H2,1-3H3
  • InChiKey: DFYAJUKJZQHIIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 582 aa 491 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0019 0.0214 0.0847
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0847 0.1587
Loa Loa (eye worm) hypothetical protein 0.0079 0.1337 0.2504
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0214 0.0847
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0427 0.0801
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Echinococcus multilocularis tumor protein p63 0.0392 0.7228 0.7228
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0031 0.0427 0.0427
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0214 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.0537 0.1006
Onchocerca volvulus 0.0013 0.0084 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0366 0.3298
Brugia malayi Tubulin alpha-2 chain 0.0212 0.3833 0.7179
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0036 0.0068
Loa Loa (eye worm) tubulin beta-4 chain 0.0292 0.5339 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0366 0.0685
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0366 0.0685
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.2571 0.4816
Brugia malayi Tubulin alpha chain 0.0067 0.1109 0.2078
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0427 0.0801
Schistosoma mansoni tubulin subunit alpha 0.0212 0.3833 0.7179
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0537 0.1006
Schistosoma mansoni tubulin subunit beta 0.0292 0.5339 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0036 0.0068
Loa Loa (eye worm) alpha-tubulin 0.0212 0.3833 0.7179
Treponema pallidum cell division protein FtsZ 0.0067 0.1109 0.5
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0214 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1109 0.2078
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0252 0.0472
Loa Loa (eye worm) hypothetical protein 0.0145 0.2571 0.4816
Echinococcus granulosus cathepsin l1 0.0019 0.0214 0.0214
Brugia malayi Tubulin gamma chain 0.0154 0.2753 0.5156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0093 0.0174
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0252 0.0472
Trypanosoma brucei tubulin delta chain 0.0067 0.1109 0.2078
Loa Loa (eye worm) tubulin alpha chain 0.0212 0.3833 0.7179
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0036 0.0068
Trypanosoma brucei epsilon tubulin 0.0154 0.2753 0.5156
Schistosoma mansoni smdr2 0.0021 0.0252 0.0472
Loa Loa (eye worm) hypothetical protein 0.0028 0.0366 0.0685
Loa Loa (eye worm) hypothetical protein 0.0021 0.0235 0.044
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0248 0.0248
Brugia malayi Cathepsin L-like precursor 0.0019 0.0214 0.04
Brugia malayi intermediate filament protein 0.0031 0.0437 0.0818
Echinococcus granulosus tubulin gamma 1 chain 0.0154 0.2753 0.2753
Echinococcus granulosus tubulin beta 4A class IVa 0.0292 0.5339 0.5339
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0031 0.0427 0.0801
Echinococcus granulosus tubulin alpha chain 0.0212 0.3833 0.3833
Leishmania major beta tubulin 0.0292 0.5339 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0366 0.0685
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0427 0.0801
Leishmania major beta tubulin 0.0292 0.5339 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0004 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0214 0.04
Echinococcus multilocularis Tubulin beta 2C chain 0.0292 0.5339 0.5339
Echinococcus multilocularis Zinc finger, PHD finger 0.0031 0.0427 0.0427
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0366 0.3298
Echinococcus granulosus intermediate filament protein 0.0031 0.0437 0.0437
Mycobacterium leprae cell division protein FtsZ 0.0067 0.1109 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Trypanosoma brucei alpha tubulin 0.0212 0.3833 0.7179
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0427 0.0801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Loa Loa (eye worm) hypothetical protein 0.0021 0.0252 0.0472
Schistosoma mansoni lamin 0.0031 0.0437 0.0818
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0193 0.0362
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0036 0.0068
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Plasmodium vivax tubulin alpha chain, putative 0.0212 0.3833 0.7179
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0214 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0366 0.3298
Onchocerca volvulus Huntingtin homolog 0.0142 0.2524 1
Leishmania major beta tubulin 0.0292 0.5339 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0125 0.2194 0.411
Echinococcus granulosus tubulin alpha 1C chain 0.0212 0.3833 0.3833
Leishmania major beta tubulin 0.0292 0.5339 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.2524 0.4727
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0036 0.0068
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0252 0.0472
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0366 0.0685
Entamoeba histolytica tubulin alpha-1 chain 0.0212 0.3833 0.7179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0847 0.0847
Schistosoma mansoni smad 0.0009 0.0026 0.0048
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0026 0.0026
Leishmania major cathepsin L-like protease 0.0019 0.0214 0.04
Echinococcus granulosus tumor protein p63 0.0392 0.7228 0.7228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Brugia malayi beta-tubulin, identical 0.0292 0.5339 1
Echinococcus multilocularis cathepsin L 0.001 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.112 0.2099
Trypanosoma brucei beta tubulin 0.0154 0.2753 0.5156
Echinococcus granulosus Tubulin alpha 1 chain 0.0212 0.3833 0.3833
Trypanosoma cruzi beta tubulin, putative 0.0292 0.5339 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0021 0.0235 0.044
Plasmodium falciparum tubulin gamma chain 0.0154 0.2753 0.5156
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0252 0.0252
Loa Loa (eye worm) tubulin beta chain 0.0292 0.5339 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Trichomonas vaginalis tubulin epsilon chain, putative 0.0212 0.3833 0.7179
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0847 0.1587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0847 0.0847
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0093 0.0174
Loa Loa (eye worm) hypothetical protein 0.0021 0.0235 0.044
Toxoplasma gondii alpha tubulin TUBA1 0.0212 0.3833 0.7179
Leishmania major cathepsin L-like protease 0.0074 0.1241 0.2325
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0252 0.0252
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0214 0.0847
Schistosoma mansoni tubulin subunit epsilon 0.0154 0.2753 0.5156
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1241 0.2325
Loa Loa (eye worm) beta-tubulin 0.0292 0.5339 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0928 0.1739
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0252 0.0472
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0252 0.0472
Loa Loa (eye worm) hypothetical protein 0.0142 0.2524 0.4727
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0004 0.0004
Echinococcus granulosus beta tubulin 0.0292 0.5339 0.5339
Loa Loa (eye worm) tubulin alpha-2 chain 0.0212 0.3833 0.7179
Echinococcus multilocularis beta tubulin 0.0292 0.5339 0.5339
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0427 0.0801
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0366 0.3298
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0114 0.1995 0.1995
Echinococcus granulosus cysteine protease 0.001 0.0036 0.0036
Brugia malayi hypothetical protein 0.0142 0.2524 0.4727
Giardia lamblia Alpha-tubulin 0.0212 0.3833 0.6439
Trypanosoma brucei alpha tubulin 0.0212 0.3833 0.7179
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0427 0.0801
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.0048
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0026 0.0048
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0193 0.0193
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0093 0.0174
Echinococcus granulosus tubulin alpha 1C chain 0.0212 0.3833 0.3833
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.2026 0.3794
Trypanosoma cruzi epsilon tubulin, putative 0.0154 0.2753 0.5156
Brugia malayi Tubulin beta-1 chain 0.0292 0.5339 1
Trichomonas vaginalis tubulin, putative 0.0087 0.1492 0.2794
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0031 0.0427 0.0801
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0427 0.0801
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0252 0.0472
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0427 0.0801
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0248
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0235 0.044
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Trichomonas vaginalis tubulin beta chain, putative 0.0212 0.3833 0.7179
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0252 0.0252
Brugia malayi MH2 domain containing protein 0.0009 0.0026 0.0048
Toxoplasma gondii beta-tubulin, putative 0.0292 0.5339 1
Echinococcus multilocularis tubulin beta 1 chain 0.0292 0.5339 0.5339
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0067 0.1109 0.5
Giardia lamblia Beta tubulin 0.0292 0.5339 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0252 0.0472
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0174
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0366 0.3298
Loa Loa (eye worm) phosphatidylinositol 3 0.0114 0.1995 0.3736
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0193 0.174
Trichomonas vaginalis tubulin alpha chain, putative 0.0087 0.1492 0.2794
Loa Loa (eye worm) hypothetical protein 0.0019 0.0214 0.04
Leishmania major beta tubulin 0.0292 0.5339 1
Trichomonas vaginalis tubulin, putative 0.0292 0.5339 1
Echinococcus multilocularis tubulin alpha chain 0.0212 0.3833 0.3833
Onchocerca volvulus 0.0019 0.0214 0.0847
Brugia malayi cathepsin L-like precursor 0.0013 0.0093 0.0174
Plasmodium vivax tubulin gamma chain, putative 0.0154 0.2753 0.5156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0193 0.0193
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0214 0.04
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1036 0.1941
Loa Loa (eye worm) tubulin alpha chain 0.0212 0.3833 0.7179
Brugia malayi tubulin alpha chain - mouse 0.0212 0.3833 0.7179
Trypanosoma brucei zeta tubulin 0.0067 0.1109 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis tubulin epsilon chain, putative 0.0292 0.5339 1
Leishmania major cathepsin L-like protease 0.0019 0.0214 0.04
Leishmania major beta tubulin 0.0292 0.5339 1
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0252 0.0472
Schistosoma mansoni lamin 0.0031 0.0437 0.0818
Onchocerca volvulus 0.0019 0.0214 0.0847
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.1492 0.2794
Brugia malayi tubulin alpha-2 chain 0.0212 0.3833 0.7179
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0036 0.0068
Trichomonas vaginalis tubulin gamma chain, putative 0.0067 0.1109 0.2078
Leishmania major beta tubulin 0.0292 0.5339 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.2456 0.4599
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0114 0.1995 0.3736
Echinococcus granulosus tubulin epsilon chain 0.0154 0.2753 0.2753
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0366 0.3298
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0282 0.516 0.516
Leishmania major beta tubulin 0.0292 0.5339 1
Trypanosoma brucei alpha tubulin 0.0212 0.3833 0.7179
Leishmania major cathepsin L-like protease 0.0019 0.0214 0.04
Plasmodium vivax vivapain-3 0.001 0.0036 0.0068
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0214 0.04
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Loa Loa (eye worm) hypothetical protein 0.0125 0.2194 0.411
Echinococcus multilocularis hypothetical protein 0.0212 0.3833 0.3833
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0475 0.089
Schistosoma mansoni hypothetical protein 0.0037 0.0537 0.1006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Leishmania major beta tubulin 0.0292 0.5339 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0252 0.0472
Trichomonas vaginalis tubulin beta chain, putative 0.0212 0.3833 0.7179
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0235 0.2118
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Onchocerca volvulus 0.0019 0.0214 0.0847
Schistosoma mansoni tubulin subunit beta 0.0292 0.5339 1
Plasmodium vivax tubulin alpha chain, putative 0.0212 0.3833 0.7179
Plasmodium vivax vivapain-1 0.001 0.0036 0.0068
Echinococcus granulosus tubulin subunit beta 0.0292 0.5339 0.5339
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0282 0.516 0.9665
Echinococcus multilocularis transcription factor eb 0.0125 0.2206 0.2206
Trypanosoma brucei beta tubulin 0.0292 0.5339 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0114 0.1995 0.3736
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0537 0.0537
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0093 0.0174
Trypanosoma cruzi zeta tubulin, putative 0.0067 0.1109 0.2078
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0107 0.1863 0.3489
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0036 0.0068
Onchocerca volvulus 0.0021 0.0252 0.0999
Loa Loa (eye worm) Smad1 0.0009 0.0026 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0426 0.0798
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Entamoeba histolytica tubulin alpha chain, putative 0.0212 0.3833 0.7179
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0252 0.0472
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0193 0.0362
Trypanosoma brucei beta tubulin 0.0292 0.5339 1
Onchocerca volvulus 0.0019 0.0214 0.0847
Echinococcus multilocularis tubulin alpha chain 0.0212 0.3833 0.3833
Onchocerca volvulus 0.0019 0.0214 0.0847
Echinococcus granulosus beta tubulin 0.0292 0.5339 0.5339
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0427 0.0801
Trichomonas vaginalis tubulin beta chain, putative 0.0212 0.3833 0.7179
Entamoeba histolytica tubulin family protein 0.0292 0.5339 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0125 0.2206 0.4131
Echinococcus multilocularis Tubulin beta 2C chain 0.0292 0.5339 0.5339
Brugia malayi Tubulin beta chain 0.0067 0.1109 0.2078
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Leishmania major beta tubulin 0.0292 0.5339 1
Loa Loa (eye worm) ctsf protein 0.0019 0.0214 0.04
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0366 0.3298
Trichomonas vaginalis tubulin epsilon chain, putative 0.0212 0.3833 0.7179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Brugia malayi alpha-tubulin 0.0212 0.3833 0.7179
Trypanosoma cruzi tubulin gamma chain 0.0154 0.2753 0.5156
Loa Loa (eye worm) BEN-1 protein 0.0292 0.5339 1
Trichomonas vaginalis abcb9, putative 0.0021 0.0252 0.0472
Schistosoma mansoni tubulin subunit beta 0.0292 0.5339 1
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0252 0.0472
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.2456 0.4599
Brugia malayi Tubulin alpha chain 0.0212 0.3833 0.7179
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0252 0.0472
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0042 0.0042
Loa Loa (eye worm) tubulin gamma chain 0.0154 0.2753 0.5156
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0193 0.0362
Echinococcus multilocularis Tubulin alpha 1 chain 0.0212 0.3833 0.3833
Loa Loa (eye worm) cysteine protease 0.0019 0.0214 0.04
Plasmodium falciparum tubulin beta chain 0.0292 0.5339 1
Brugia malayi Cathepsin L-like precursor 0.0013 0.0093 0.0174
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.013 0.013
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0031 0.0427 0.0801
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0252 0.0252
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0235 0.044
Echinococcus multilocularis tubulin alpha 3 chain 0.0212 0.3833 0.3833
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Leishmania major delta tubulin, putative 0.0067 0.1109 0.2078
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0366 0.0685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Trypanosoma cruzi tubulin delta chain 0.0067 0.1109 0.2078
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0031 0.0427 0.0427
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0252 0.0252
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0366 0.0685
Brugia malayi multidrug resistance protein 3 0.0021 0.0252 0.0472
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Trichomonas vaginalis tubulin alpha chain, putative 0.0154 0.2753 0.5156
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0193 0.0193
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0282 0.516 0.516
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0252 0.0252
Echinococcus granulosus Tubulin beta 2C chain 0.0292 0.5339 0.5339
Leishmania major cathepsin L-like protease 0.0019 0.0214 0.04
Onchocerca volvulus 0.0019 0.0214 0.0847
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0427 0.0801
Loa Loa (eye worm) tubulin alpha 2 0.0057 0.0928 0.1738
Onchocerca volvulus Huntingtin homolog 0.0142 0.2524 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0252 0.0472
Trypanosoma brucei tubulin gamma chain 0.0154 0.2753 0.5156
Echinococcus multilocularis tubulin subunit beta 0.0292 0.5339 0.5339
Trypanosoma brucei zeta tubulin, putative 0.0067 0.1109 0.2078
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0214 0.0847
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0036 0.0068
Trichomonas vaginalis tubulin, putative 0.0087 0.1492 0.2794
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0427 0.0801
Echinococcus multilocularis tubulin alpha chain 0.0212 0.3833 0.3833
Trypanosoma brucei alpha tubulin, putative 0.0087 0.1492 0.2794
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0114 0.1995 0.3736
Trichomonas vaginalis tubulin beta chain, putative 0.0292 0.5339 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0366 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Brugia malayi Cell division protein ftsZ 0.0067 0.1109 0.2078
Echinococcus granulosus tubulin alpha chain 0.0212 0.3833 0.3833
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0427 0.0801
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.2026 0.3794
Brugia malayi MH2 domain containing protein 0.0139 0.2456 0.4599
Plasmodium falciparum tubulin delta chain, putative 0.0067 0.1109 0.2078
Trypanosoma brucei beta tubulin 0.0292 0.5339 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0026 0.0026
Schistosoma mansoni Smad4 0.0009 0.0026 0.0048
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0214 0.0214
Plasmodium vivax tubulin beta chain, putative 0.0292 0.5339 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0193 0.0362
Trichomonas vaginalis tubulin alpha chain, putative 0.0292 0.5339 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0145 0.2571 0.4816
Brugia malayi Tubulin alpha-2 chain 0.0212 0.3833 0.7179
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0252 0.0472
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0193 0.0362
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0031 0.0427 0.0801
Schistosoma mansoni hypothetical protein 0.0037 0.0537 0.1006
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0252 0.0252
Echinococcus multilocularis tubulin alpha 0.0154 0.2753 0.2753
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0004
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0235 0.2118
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0026 0.0048
Entamoeba histolytica cysteine protease, putative 0.0019 0.0214 0.04
Trypanosoma brucei beta tubulin 0.0292 0.5339 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0252 0.0472
Giardia lamblia Beta tubulin 0.0292 0.5339 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0145 0.2571 0.4816
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0437 0.0818
Schistosoma mansoni tubulin subunit beta 0.0292 0.5339 1
Echinococcus granulosus tubulin alpha 3 chain 0.0212 0.3833 0.3833
Echinococcus granulosus tubulin alpha 0.0154 0.2753 0.2753
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0214 0.04
Schistosoma mansoni tubulin subunit delta 0.0067 0.1109 0.2078
Loa Loa (eye worm) fibroinase 0.0019 0.0214 0.04
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0193 0.0362
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0132 0.0132
Toxoplasma gondii beta-1 tubulin, putative 0.0292 0.5339 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0235 0.044
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.0048
Plasmodium vivax vivapain-2 0.0019 0.0214 0.04
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0193 0.0362
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0366 0.3298
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0427 0.0801
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.0464
Brugia malayi Cathepsin L-like precursor 0.0013 0.0093 0.0174
Trypanosoma cruzi alpha tubulin, putative 0.0212 0.3833 0.7179
Schistosoma mansoni hypothetical protein 0.0037 0.0537 0.1006
Schistosoma mansoni cpg binding protein 0.0035 0.0511 0.0957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Echinococcus granulosus alpha tubulin 0.0212 0.3833 0.3833
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0036 0.0068
Brugia malayi MH2 domain containing protein 0.0009 0.0026 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.1337 0.2504
Schistosoma mansoni tubulin subunit beta 0.0292 0.5339 1
Echinococcus granulosus tubulin delta chain 0.0067 0.1109 0.1109
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0366 0.3298
Mycobacterium tuberculosis Cell division protein FtsZ 0.0067 0.1109 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0252 0.0472
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0036 0.0068
Leishmania major cathepsin L-like protease 0.0074 0.1241 0.2325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0943 0.1767
Mycobacterium ulcerans hypothetical protein 0.0028 0.0366 0.3298
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.2571 0.4816
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0252 1
Echinococcus multilocularis lamin dm0 0.0031 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0083 0.1415 0.2651
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0154 0.2753 0.5156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0847 0.1587
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0214 0.0214
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0437 0.0818
Onchocerca volvulus 0.0028 0.0366 0.1449
Echinococcus multilocularis cysteine protease 0.0019 0.0214 0.0214
Leishmania major gamma-tubulin 0.0154 0.2753 0.5156
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Echinococcus multilocularis tubulin gamma 1 chain 0.0154 0.2753 0.2753
Leishmania major cathepsin L-like protease 0.0074 0.1241 0.2325
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Brugia malayi ABC transporter family protein 0.0021 0.0252 0.0472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0847 0.1587
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0004 0.0004
Schistosoma mansoni tubulin subunit alpha 0.0212 0.3833 0.7179
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0114 0.1995 0.3736
Giardia lamblia Alpha-tubulin 0.0212 0.3833 0.6439
Loa Loa (eye worm) hypothetical protein 0.0021 0.0252 0.0472
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0252 0.0252
Echinococcus granulosus Tubulin beta 2C chain 0.0292 0.5339 0.5339
Echinococcus multilocularis tubulin alpha 1C chain 0.0212 0.3833 0.3833
Onchocerca volvulus 0.0087 0.1492 0.591
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0212 0.3833 0.7179
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1241 0.2325
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0132 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Loa Loa (eye worm) BEN-1 protein 0.0292 0.5339 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0212 0.3833 0.3833
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0427 0.0801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0847 0.1587
Leishmania major beta tubulin 0.0292 0.5339 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.2189 0.41
Echinococcus granulosus lamin dm0 0.0031 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0212 0.3833 0.7179
Echinococcus multilocularis musashi 0.0031 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.0019 0.0214 0.04
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0366 0.0685
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0214 0.04
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0031 0.0427 0.0427
Schistosoma mansoni cpg binding protein 0.0035 0.0511 0.0957
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0031 0.0427 0.0427
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis tubulin gamma chain, putative 0.0292 0.5339 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0174
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0031 0.0427 0.0801
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0252 0.0472
Echinococcus granulosus cathepsin L 0.001 0.0036 0.0036
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.013 0.013
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0114 0.1995 0.3736
Trypanosoma cruzi epsilon tubulin, putative 0.0154 0.2753 0.5156
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0067 0.1109 0.2078
Brugia malayi Cathepsin L-like precursor 0.0019 0.0214 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0121 0.0227
Loa Loa (eye worm) hypothetical protein 0.0021 0.0235 0.044
Echinococcus multilocularis neuropeptide receptor A26 0.054 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0366 0.3298
Trichomonas vaginalis tubulin beta chain, putative 0.0212 0.3833 0.7179
Leishmania major beta tubulin 0.0292 0.5339 1
Leishmania major beta tubulin 0.0292 0.5339 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0214 0.04
Schistosoma mansoni tubulin subunit beta 0.0067 0.1109 0.2078
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0437 0.0818
Echinococcus granulosus Tubulin alpha 1 chain 0.0212 0.3833 0.3833
Plasmodium vivax unspecified product 0.001 0.0036 0.0068
Toxoplasma gondii alpha-tubulin I, putative 0.0212 0.3833 0.7179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1178 0.2207
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0537 0.1006
Schistosoma mansoni multidrug resistance protein 0.0021 0.0252 0.0472
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0214 0.1927
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0252 0.2274
Leishmania major beta tubulin 0.0292 0.5339 1
Trypanosoma brucei epsilon tubulin 0.0154 0.2753 0.5156
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0252 0.0472
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Loa Loa (eye worm) alpha-tubulin 0.0212 0.3833 0.7179
Entamoeba histolytica cysteine proteinase 2 0.001 0.0036 0.0068
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0252 0.0252
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0026 0.0026
Echinococcus granulosus tubulin alpha chain 0.0212 0.3833 0.3833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0036 0.0068
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0067 0.1109 0.2078
Schistosoma mansoni multidrug resistance protein 0.0021 0.0252 0.0472
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0193 0.0193
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0214 0.0214
Onchocerca volvulus 0.0031 0.0437 0.1731
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0031 0.0427 0.0801
Loa Loa (eye worm) hypothetical protein 0.0057 0.0928 0.1739
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0193 0.0362
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0252 0.0472
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0252 0.0472
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0036 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0537 0.0537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis tubulin alpha chain, putative 0.0087 0.1492 0.2794
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0031 0.0427 0.0801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trypanosoma cruzi tubulin delta chain 0.0067 0.1109 0.2078
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0366 0.0685
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0214 0.04
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0093 0.0174
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0252 0.0252
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0214 0.04
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0031 0.0427 0.0801
Echinococcus multilocularis tubulin alpha chain 0.0212 0.3833 0.3833
Schistosoma mansoni multidrug resistance protein 0.0021 0.0252 0.0472
Trichomonas vaginalis abcb9, putative 0.0021 0.0252 0.0472
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0024 0.0296 0.0554
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0252 0.0472
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0067 0.1109 0.2078
Schistosoma mansoni cpg binding protein 0.0033 0.0475 0.089
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0193 0.0193
Loa Loa (eye worm) histone methyltransferase 0.001 0.0042 0.0079
Onchocerca volvulus 0.0057 0.0928 0.3678
Echinococcus granulosus tubulin beta 1 chain 0.0292 0.5339 0.5339
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0214 0.1927
Brugia malayi Cathepsin L-like precursor 0.0019 0.0214 0.04
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0193 0.0362
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Trypanosoma brucei epsilon tubulin 0.0154 0.2753 0.5156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0174
Plasmodium falciparum tubulin epsilon chain, putative 0.0154 0.2753 0.5156
Echinococcus multilocularis GPCR, family 2 0.0037 0.0537 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis taga, putative 0.0021 0.0252 0.0472
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0214 0.04
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0026 0.0048
Plasmodium vivax tubulin epsilon chain, putative 0.0154 0.2753 0.5156
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0114 0.1995 0.3736
Brugia malayi MH1 domain containing protein 0.0009 0.0026 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0214 0.1927
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0427 0.0801
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Brugia malayi Smad1 0.0009 0.0026 0.0048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0163 0.0306
Echinococcus granulosus tubulin alpha 3 chain 0.0212 0.3833 0.3833
Leishmania major zeta tubulin, putative 0.0067 0.1109 0.2078
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0036 0.0036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0537 0.0537
Echinococcus multilocularis Tubulin alpha 1 chain 0.0212 0.3833 0.3833
Entamoeba histolytica tubulin family protein 0.0292 0.5339 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0427 0.0801
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0036 0.0068
Schistosoma mansoni alpha tubulin 0.0212 0.3833 0.7179
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0114 0.1995 0.3736
Echinococcus granulosus Tubulin beta 2C chain 0.0292 0.5339 0.5339
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0214 0.04
Loa Loa (eye worm) tubulin beta-1 chain 0.0292 0.5339 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0366 0.0685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0214 0.1927
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0193 0.0362
Leishmania major alpha tubulin 0.0212 0.3833 0.7179
Schistosoma mansoni tubulin subunit alpha 0.0067 0.1109 0.2078
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0015 0.0121 0.0227
Brugia malayi CXXC zinc finger family protein 0.0033 0.0475 0.089
Entamoeba histolytica hypothetical protein 0.0114 0.1995 0.3736
Entamoeba histolytica tubulin gamma chain 0.0154 0.2753 0.5156
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0114 0.1995 0.2093
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0537 0.1006
Trichomonas vaginalis tubulin gamma chain, putative 0.0154 0.2753 0.5156
Leishmania major epsilon tubulin, putative 0.0154 0.2753 0.5156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.1995 0.3736
Schistosoma mansoni intermediate filament proteins 0.0031 0.0437 0.0818
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Giardia lamblia Beta tubulin 0.0292 0.5339 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.013 0.0244
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0427 0.0801
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0004
Trichomonas vaginalis tubulin alpha chain, putative 0.0087 0.1492 0.2794
Echinococcus granulosus smad 0.0009 0.0026 0.0026
Trichomonas vaginalis abcb9, putative 0.0021 0.0252 0.0472
Loa Loa (eye worm) hypothetical protein 0.0031 0.0427 0.0801
Echinococcus multilocularis Tubulin beta 2C chain 0.0292 0.5339 0.5339
Echinococcus granulosus cathepsin l1 0.0013 0.0093 0.0093
Plasmodium falciparum alpha tubulin 1 0.0212 0.3833 0.7179
Leishmania major beta tubulin 0.0292 0.5339 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0366 0.3298
Brugia malayi Cathepsin L-like precursor 0.0019 0.0214 0.04
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.013 0.013
Echinococcus granulosus GPCR family 2 0.0037 0.0537 0.0537
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0214 0.04
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0252 0.0472
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0193 0.0362
Echinococcus multilocularis Tubulin beta 2C chain 0.0292 0.5339 0.5339
Trichomonas vaginalis tubulin, putative 0.0067 0.1109 0.2078
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0031 0.0427 0.0801
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0292 0.5339 0.5339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0427 0.0801
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0847 0.0847
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0163 0.0306
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0036 0.0068
Giardia lamblia Gamma tubulin 0.0154 0.2753 0.3886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Echinococcus multilocularis tubulin alpha 1C chain 0.0212 0.3833 0.3833
Echinococcus granulosus Tubulin beta 2C chain 0.0292 0.5339 0.5339
Leishmania major cathepsin L-like protease 0.0019 0.0214 0.04
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Loa Loa (eye worm) tubulin beta chain 0.0067 0.1109 0.2078
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0114 0.1995 0.1995
Trichomonas vaginalis tubulin gamma chain, putative 0.0154 0.2753 0.5156
Echinococcus granulosus tubulin alpha chain 0.0212 0.3833 0.3833
Echinococcus multilocularis lamin 0.0031 0.0437 0.0437
Schistosoma mansoni alpha tubulin 0.0212 0.3833 0.7179
Plasmodium vivax delta tubulin, putative 0.0067 0.1109 0.2078
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0437 0.0818
Echinococcus granulosus transcription factor eb 0.0125 0.2206 0.2206
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0248 0.0248
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0214 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1109 0.2078
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0252 0.0252
Echinococcus multilocularis smad 0.0009 0.0026 0.0026
Trypanosoma cruzi cysteine protease, putative 0.001 0.0036 0.0068
Echinococcus granulosus peroxisome assembly protein 26 0.0212 0.3833 0.3833
Echinococcus multilocularis tubulin delta chain 0.0067 0.1109 0.1109
Schistosoma mansoni hypothetical protein 0.0079 0.1337 0.2504
Brugia malayi Cathepsin L-like precursor 0.0019 0.0214 0.04
Trypanosoma brucei alpha tubulin 0.0212 0.3833 0.7179
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0252 0.0472
Echinococcus multilocularis Tubulin beta 2C chain 0.0292 0.5339 0.5339
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0214 0.04
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.1241 0.2325
Onchocerca volvulus 0.0033 0.0475 0.1883
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0114 0.1995 0.3736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0036 0.0068
Brugia malayi Tubulin beta chain 0.0087 0.1492 0.2794
Echinococcus multilocularis cysteine protease 0.0019 0.0214 0.0214
Echinococcus multilocularis tubulin epsilon chain 0.0154 0.2753 0.2753
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.004 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.0296 0.0554
Echinococcus granulosus Smad4 0.0009 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0116 0.2026 0.3794
Brugia malayi isocitrate dehydrogenase 0.0018 0.0193 0.0362
Echinococcus granulosus neuropeptide receptor A26 0.054 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Echinococcus multilocularis neuropeptide s receptor 0.054 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0537 0.1006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis tubulin epsilon chain, putative 0.0067 0.1109 0.2078
Echinococcus granulosus cpg binding protein 0.0035 0.0511 0.0511
Schistosoma mansoni alpha tubulin 0.0212 0.3833 0.7179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0427 0.0801
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0252 0.0252
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0087 0.1492 0.2794
Echinococcus multilocularis tubulin alpha chain 0.0212 0.3833 0.3833
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0193 0.0193
Echinococcus multilocularis Smad4 0.0009 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Schistosoma mansoni tubulin subunit alpha 0.0212 0.3833 0.7179
Leishmania major p-glycoprotein 0.0021 0.0252 0.0472
Echinococcus multilocularis Tubulin alpha 1 chain 0.0212 0.3833 0.3833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Leishmania major beta tubulin 0.0292 0.5339 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0036 0.0068
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0036 0.0068
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0114 0.1995 0.3736
Leishmania major beta tubulin 0.0292 0.5339 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0252 0.0252
Echinococcus multilocularis cpg binding protein 0.0035 0.0511 0.0511
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0214 0.0214
Loa Loa (eye worm) tubulin alpha-3 chain 0.0124 0.2189 0.41
Toxoplasma gondii cathepsin CPL 0.0019 0.0214 0.04
Onchocerca volvulus 0.0031 0.0437 0.1731
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1241 0.2325
Mycobacterium ulcerans cell division protein FtsZ 0.0067 0.1109 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0031 0.0427 0.0801
Trypanosoma cruzi zeta tubulin, putative 0.0067 0.1109 0.2078
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0252 0.0472
Trichomonas vaginalis tubulin epsilon chain, putative 0.0292 0.5339 1
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0252 0.0472
Echinococcus granulosus lamin 0.0031 0.0437 0.0437
Echinococcus granulosus tubulin alpha chain 0.0212 0.3833 0.3833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Loa Loa (eye worm) tubulin beta-2A chain 0.0292 0.5339 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0212 0.3833 0.3833
Echinococcus multilocularis tubulin alpha 3 chain 0.0212 0.3833 0.3833
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0036 0.0068
Onchocerca volvulus 0.0013 0.0093 0.0368
Echinococcus granulosus Tubulin beta 2C chain 0.0292 0.5339 0.5339
Schistosoma mansoni tubulin subunit beta 0.0292 0.5339 1
Schistosoma mansoni tubulin subunit gamma 0.0154 0.2753 0.5156
Echinococcus multilocularis beta tubulin 0.0292 0.5339 0.5339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Brugia malayi MH1 domain containing protein 0.0009 0.0026 0.0048
Entamoeba histolytica cysteine protease, putative 0.001 0.0036 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.2026 0.3794
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0114 0.1995 0.3736
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0214 0.04
Trichomonas vaginalis tubulin beta chain, putative 0.0212 0.3833 0.7179
Plasmodium falciparum alpha tubulin 2 0.0212 0.3833 0.7179
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0252 0.0472
Leishmania major beta tubulin 0.0292 0.5339 1
Toxoplasma gondii beta tubulin 0.0292 0.5339 1
Echinococcus multilocularis tubulin subunit TubB 0.0212 0.3833 0.3833
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0252 0.0472
Plasmodium vivax vivapain-2 0.0019 0.0214 0.04
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0193 0.0362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1241 0.2325
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0031 0.0427 0.0427
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0036 0.0068
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0124 0.2189 0.41
Loa Loa (eye worm) hypothetical protein 0.0028 0.0366 0.0685
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.0048
Echinococcus granulosus tubulin subunit TubB 0.0212 0.3833 0.3833
Trichomonas vaginalis tubulin beta chain, putative 0.0212 0.3833 0.7179

Activities

Activity type Activity value Assay description Source Reference
CLH (ADMET) = 13 uL/min Intrinsic clearance in human hepatocytes measured per 10'6 cells ChEMBL. 24992874
IC50 (binding) = 0.011 uM Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assay ChEMBL. 24992874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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